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MCID: HYP457
MIFTS: 42

Hypertrophic Scars

Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Hypertrophic Scars

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MalaCards integrated aliases for Hypertrophic Scars:

Name: Hypertrophic Scars 40
Scars Hypertrophic 54

Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

ICD10 32 L91.0
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Summaries for Hypertrophic Scars

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MalaCards based summary : Hypertrophic Scars, also known as scars hypertrophic, is related to keloid disorder and scleroderma, familial progressive. An important gene associated with Hypertrophic Scars is TGFB1 (Transforming Growth Factor Beta 1), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Clobetasol and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and bone, and related phenotypes are growth/size/body region and cardiovascular system

Wikipedia : 74 A hypertrophic scar is a cutaneous condition characterized by deposits of excessive amounts of collagen... more...

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Related Diseases for Hypertrophic Scars

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Diseases related to Hypertrophic Scars via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 keloid disorder 30.8 TGFB1 SMAD3 CD36 BMP6
2 scleroderma, familial progressive 30.5 CD36 BMP6
3 localized scleroderma 29.8 TGFB1 SMAD3 BMP6
4 renal fibrosis 27.1 TIMP1 TGFB1 SMAD3 SMAD2 MMP2 CD36
5 epidermolysis bullosa dystrophica, pretibial 11.3
6 myhre syndrome 11.2
7 desmoid tumor 11.2
8 keloid formation 10.4
9 skin disease 10.3
10 neurofibromatosis, type ii 10.3
11 dowling-degos disease 1 10.3
12 ocular cicatricial pemphigoid 10.3 TGFB1 CD36
13 osteofibrous dysplasia 10.3 TGFB1 CD36
14 overgrowth syndrome 10.2
15 osteochondrosis 10.2 TGFB1 CD36
16 folliculitis 10.2
17 cholecystolithiasis 10.2 TGFB1 BMP6
18 dupuytren contracture 10.2 TGFB1 BMP6
19 eosinophilia-myalgia syndrome 10.2 TGFB1 BMP6
20 fibrosis of extraocular muscles, congenital, 1 10.2
21 exanthem 10.2
22 telangiectasis 10.2
23 cytokine deficiency 10.2
24 microvascular complications of diabetes 3 10.1 TGFB1 BMP6
25 odontogenic myxoma 10.1 MMP2 CD36
26 juvenile nasopharyngeal angiofibroma 10.1 TGFB3 BMP6
27 frozen shoulder 10.1 TGFB1 MMP2
28 rickets 10.1
29 skin atrophy 10.1
30 herpes zoster 10.1
31 vitreous disease 10.1 SMAD2 MMP2
32 proteasome-associated autoinflammatory syndrome 1 10.0
33 basal cell carcinoma 10.0
34 systemic scleroderma 10.0
35 stevens-johnson syndrome/toxic epidermal necrolysis 10.0
36 autosomal dominant non-syndromic intellectual disability 19 10.0 SMAD3 SMAD2
37 breast cyst 10.0 TGFB1 BMP6
38 albinism, ocular, with late-onset sensorineural deafness 10.0 SMAD3 SMAD2
39 tricuspid valve prolapse 10.0 TGFB3 SMAD3
40 palmoplantar keratoderma, nonepidermolytic 10.0 TGFB3 KRT16
41 fibrochondrogenesis 10.0 TGFB3 BMP6
42 bullous keratopathy 10.0 TGFB3 TGFB1
43 gastroschisis 10.0 TGFB3 BMP6
44 heritable thoracic aortic disease 10.0 TGFB3 SMAD3
45 sarcoidosis 1 10.0
46 galactorrhea 10.0
47 retinal dystrophy, iris coloboma, and comedogenic acne syndrome 10.0
48 hyperprolactinemia 10.0
49 sarcoma 10.0
50 purpura 10.0

Graphical network of the top 20 diseases related to Hypertrophic Scars:



Diseases related to Hypertrophic Scars
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Symptoms & Phenotypes for Hypertrophic Scars

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MGI Mouse Phenotypes related to Hypertrophic Scars:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.11 BMP6 CD36 KRT16 MMP2 SMAD2 SMAD3
2 cardiovascular system MP:0005385 10.05 CD36 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
3 homeostasis/metabolism MP:0005376 10.01 CD36 KRT16 MMP2 SMAD2 SMAD3 TGFB1
4 hematopoietic system MP:0005397 9.98 CD36 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
5 craniofacial MP:0005382 9.97 KRT16 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
6 digestive/alimentary MP:0005381 9.95 CD36 KRT16 SMAD2 SMAD3 TGFB1 TGFB3
7 mortality/aging MP:0010768 9.92 CD36 KRT16 MMP2 SMAD2 SMAD3 TGFB1
8 immune system MP:0005387 9.91 CD36 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
9 neoplasm MP:0002006 9.65 MMP2 SMAD2 SMAD3 TGFB1 TIMP1
10 skeleton MP:0005390 9.56 BMP6 CD36 MMP2 SMAD2 SMAD3 TGFB1
11 respiratory system MP:0005388 9.55 MMP2 SMAD2 TGFB1 TGFB3 TIMP1
12 vision/eye MP:0005391 9.1 CD36 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
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Drugs & Therapeutics for Hypertrophic Scars

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Drugs for Hypertrophic Scars (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clobetasol Approved, Experimental, Investigational Phase 4 25122-41-2, 25122-46-7 32798 5311051
2
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
3
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
4
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
5
Ethanol Approved Phase 4 64-17-5 702
6
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
7
leucovorin Approved Phase 4 58-05-9 6006 143
8
Dapsone Approved, Investigational Phase 4 80-08-0 2955
9
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
10
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
11 Tocotrienol Investigational Phase 4 6829-55-6
12 Dermatologic Agents Phase 4
13 Emollients Phase 4
14 Trace Elements Phase 4
15 Nutrients Phase 4
16 Micronutrients Phase 4
17 Vitamins Phase 4
18 Antioxidants Phase 4
19 Hydrocortisone 17-butyrate 21-propionate Phase 4
20 Hydrocortisone hemisuccinate Phase 4
21 Tocopherols Phase 4
22 Tocotrienols Phase 4
23 Sodium Channel Blockers Phase 4
24 Anesthetics Phase 4
25 Anti-Arrhythmia Agents Phase 4
26 Anesthetics, Local Phase 4
27 Diuretics, Potassium Sparing Phase 4
28 Anti-Bacterial Agents Phase 4
29 Anti-Infective Agents Phase 4
30 Antiparasitic Agents Phase 4
31 Antiprotozoal Agents Phase 4
32 Vitamin B Complex Phase 4
33 Folic Acid Antagonists Phase 4
34 Folate Phase 4
35 Vitamin B9 Phase 4
36 Antimalarials Phase 4
37
Fusidic Acid Approved, Investigational Phase 3 6990-06-3 3000226
38
carbamide peroxide Approved Phase 3 124-43-6
39
Thrombin Approved, Investigational Phase 2, Phase 3
40
Acetylcholine Approved, Investigational Phase 2, Phase 3 51-84-3 187
41 Cola Phase 3
42 Gotu Kola Phase 3
43 abobotulinumtoxinA Phase 2, Phase 3
44 Botulinum Toxins, Type A Phase 2, Phase 3
45 Cholinergic Agents Phase 2, Phase 3
46 Neurotransmitter Agents Phase 2, Phase 3
47 Botulinum Toxins Phase 2, Phase 3
48
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
49
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
50 Retinol palmitate Phase 2

Interventional clinical trials:

(show top 50) (show all 62)
# Name Status NCT ID Phase Drugs
1 Use of Silicone Gel to Improve Retroauricular Scar in Microtia Patients Unknown status NCT02518035 Phase 4 Silicone Gel
2 Treatment of Hypertrophic Scars Using Fractional Laser and Fractional Laser-assisted Topical Corticosteroid Delivery Completed NCT02487212 Phase 4 0.05% Clobetasol propionate;Petrolatum gel
3 Effect of Transparent, Self-drying Silicone Gel on the Treatment of Hypertrophic Abdominal Scars Completed NCT01078428 Phase 4
4 1540nm Non Ablative Fractional Laser Treatment of Scars : a Prospective Single Blinded Within Patient Controlled Randomized Trial. Completed NCT01056211 Phase 4
5 Effect of Silicone Gel Versus Contractubex Phonophoresis for Post-burn Hypertrophic Scars: A Single Blind Randomized Controlled Trial Completed NCT03777891 Phase 4
6 Assessment of Efficacy, Safety and Tolerability of Stratamark® (Innovative Self-drying Silicone Gel) in the Treatment and Prevention of Striae Distensae Completed NCT03377231 Phase 4
7 A Prospective, Randomized, Investigator-blinded, Placebo-controlled, Comparative Study Evaluating the Tolerability and Efficacy of Two Topical Therapies for the Treatment of Keloids and Hypertrophic Scars Completed NCT00754247 Phase 4 0.5% hydrocortisone, silicone, vitamin E lotion;Onion extract gel;Cetearyl alcohol lotion
8 Intralesional Injection of Steroids and/or Botulinum Toxin Type A in Hypertrophic Scars and Keloids for Pain Improvement Recruiting NCT03982862 Phase 4 Triamcinolone;Lidocaine;Botulinum toxin A
9 An Open-label Study to Investigate the Efficacy and Tolerability of Aczone Gel, 7.5% in the Treatment of Acne Vulgaris in Men and Women With Skin of Color Recruiting NCT03681470 Phase 4 Aczone Gel
10 Topical Treatment With Glucocorticoids to Prevent Hypertrophic Scars and Keloid Due to Central Venous Access in Children Unknown status NCT01113125 Phase 3 Betamethason-17-valerate and fusidic acid;Fusidic Acid
11 Botulinum Toxin to Improve Results in Epicanthoplasty Unknown status NCT03294382 Phase 3 Botulinum toxin type A;Placebo
12 Efficacy of CICATRIX (Asian Gotu Kola or Pennywort) in the Treatment of Hypertrophic Scars and Keloids Scars. Completed NCT00993005 Phase 3
13 Silicone Gel Versus Onion Extract Gel as Prevention for Postsurgical Scars: a Randomized Controlled Trial Completed NCT01861119 Phase 3 Silicone gel Kelo-cortâ„¢;;Onion extract gel Contractubexâ„¢
14 Clinical Evaluation of Silicone Gel in the Treatment of Cleft Lip Scars Completed NCT03314090 Phase 3 Silicone Gels
15 Role of Topical Putrescine (Fibrostat) in 10%Urea (TFU) for Prevention of Hypertrophic Scars in Mammoplasty Patients Completed NCT03376620 Phase 3 1,4-Diaminobutane;10% Urea cream
16 An Open-label, Non Randomized, Single-Center Registry Study to Assess the Safety and Effects of Autologous Platelets Concentrate and Autologous Thrombin for the Treatment of Deep Burns Trauma Completed NCT01383187 Phase 2, Phase 3
17 The Efficacy and Molecular Mechanism of Botulinum Toxin in the Reduction of Breast Reduction Mammoplasty Scar Formation: A Prospective, Controlled, Randomized, Double-blinded Study Not yet recruiting NCT03887377 Phase 2, Phase 3 Botulinum Toxins;Normal saline
18 Influencing Wound Healing Through the Application of Hyaluronic Acid With Perfluorodecalin and Physalis Angulata Extract After Split Skin Removal From the Thigh - A Study in "Split Wound Design" Withdrawn NCT03668665 Phase 3 Ready Medical Post Treatment
19 An Open-Label, Multi-Center, Prospective, Within-Subject Controlled, Phase 2a Study to Evaluate the Effectiveness and Safety of RXI 109 on the Outcome of Scar Revision Surgery for Hypertrophic Scars in Healthy Adults Unknown status NCT02246465 Phase 2 RXI-109
20 Botulinum Toxin A in the Healing of Surgical Wounds of the Neck: a Randomized, Prospective, Placebo-controlled Trial Unknown status NCT01177358 Phase 2 Botulinum Toxin Type A;Normal Saline
21 Phase 2 Of Injectable Collagenase (Xiaflex) For Burns' Associated Contracture Unknown status NCT01237964 Phase 2 Xiaflex (FDA approved collagenase)
22 A Multi-Center, Prospective, Randomized, Double-Blind, Within-Subject Controlled, Phase 2a Study to Evaluate the Effectiveness and Safety of RXI 109 on the Outcome of Scar Revision Surgery on Transverse Hypertrophic Scars on the Lower Abdomen Resulting From Previous Surgeries in Healthy Adults Completed NCT02030275 Phase 2 RXI-109;Placebo
23 A Phase 2, Open-label Study to Provide Revision of Scars Resulting From Surgery in Prior Studies of EXC 001 (Currently Called PF-06473871) Completed NCT01494922 Phase 2 EXC 001 (currently called PF-06473871)
24 Treatment of Hypertrophic Scars With Intradermal Botox Recruiting NCT03631368 Phase 2 Botox
25 A Long-term Efficacy Assessment Following Initial Scar Revision Surgery And Phase 2 Open-label Study To Evaluate Safety Of Re-treatment With Pf-06473871 Terminated NCT02205476 Phase 2 PF-06473871;PF-06473871
26 Phase II Trial of Sorafenib in Patients With Extensive Keloids Terminated NCT01425216 Phase 2 Sorafenib
27 Within-subject Randomized Clinical Trial Comparing Dual-mode ER:YAG Laser in Patients With Long Keloid/Hypertrophic Scars Withdrawn NCT02546076 Phase 2
28 A Phase 1, Single Center, Placebo-controlled, Interventional Study to Evaluate the Safety, Tolerability, and Pharmacokinetic Profiles in Healthy Subjects Compared to Placebo Completed NCT03569267 Phase 1 OLX10010;Placebo
29 The Safety of Topically Delivered FS2 in Humans. Phase 1 Clinical Trial Completed NCT02340325 Phase 1 Acute Application of kynurenic acid cream;Chronic application of kynurenic acid cream
30 Double Blind, Single-Center, Randomized, Within Subject Placebo, Phase I Study Evaluating the Effects of Novel Topical Gel in Prevention of Hypertrophic Scar Formation Recruiting NCT03403621 Phase 1 Pentamidine Isethionate;Silicone Gels
31 A Pilot Study of Intralesional Injection of Triamcinolone Acetonide for Desmoid Tumors Active, not recruiting NCT03627741 Phase 1 Triamcinolone Acetonide
32 Comparison of the Blister Fluid Components of Second Degree Burned Patients With the Blister Fluid Components Following Intralesional Cryosurgery of Keloid Scars - A Feasibility Study. Unknown status NCT01627769
33 Dermatix; A Randomized Controlled Trial Measuring Effectivity of Dermatix in Promoting Scar Maturation of Hypertrophic Scars. Unknown status NCT00548210
34 Tunable-Dye Laser Therapy to Ameliorate Hypertrophic Scarring in Burned Children Unknown status NCT01653691
35 Comparison of the Effectiveness in Prevention of Hypertrophic Scars or Keloids Between Silicone Sheet, Silicone Gel and Paper Steri-strip-A Randomised Controlled Trial. Unknown status NCT00849004
36 Intralesional Cryosurgery for the Treatment of Basal Cell Carcinoma of the Lower Extremities in the Elderly - a Feasibility Study Unknown status NCT01633515
37 A Single-arm, Observational Study to Explore and Characterize Wound Healing After Skin Punch Biopsies in Healthy Volunteers Unknown status NCT03433820
38 Intralesional Cryotherapy With a Argon Gas Based Device for the Treatment of Keloid and Hypertrophic Scars Completed NCT02063243
39 Intralesional Cryotherapy for Treatment of Keloid Scars: a Prospective Evaluation Completed NCT01994616
40 Effect of Pulse Width of a 595-nm Flashlamp-pumped Pulsed-dye Laser on the Treatment Response of Keloidal and Hypertrophic Sternotomy Scars Completed NCT00142441
41 Randomized, Controlled, Within-patient, Single-blinded Pilot Study to Evaluate the Efficacy of the Ablative Fractional CO2 Laser in the Treatment of Hypertrophic Scars in Adult Burn Patients Completed NCT03240718
42 Rejuvenation of Post Burn Scars on the Face With Unfiltered Nanofat Injection Completed NCT03352297
43 Pilot Study of Prospective Clinical Trials on Skin Wound Healing in Young and Aged Individuals Completed NCT01040104
44 Comparison of the Effectiveness of the Pulsed Dye Laser 585nm Versus 595nm in the Treatment of New Surgical Scars Completed NCT00482144
45 Effectiveness and Tolerability of an Overnight 4-week Treatment With Patch Containing Onion Extract and Allantoin for Cesarean Section Scars Completed NCT04046783
46 The Clinical Utility of Extracorporeal Shock Wave Therapy on Burns of Upper Extremity : Controlled, Randomization, Double Bilind Study Completed NCT04340271
47 Effects of Virtual Reality Based Rehabilitation on Burned Hands a Prospective, Randomized, Single Blined Study Completed NCT03865641
48 Observational Study of Keloids Scars Treated by Shaving and Cryosurgery Recruiting NCT02886091
49 "A Prospective, Randomized, Double-blind, Placebo Controlled and Comparative Clinical Study Evaluating Scar-management Modalities for Simple and Effective Management of Hyperproliferative (Hypertrophic) Scars and Keloids" Recruiting NCT04169490
50 Understanding and Reversing Chronic Radiation Dermatitis - A Pilot Study Recruiting NCT01910818

Search NIH Clinical Center for Hypertrophic Scars

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Genetic Tests for Hypertrophic Scars

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Anatomical Context for Hypertrophic Scars

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MalaCards organs/tissues related to Hypertrophic Scars:

40
Skin, Breast, Bone, Endothelial, Liver, Smooth Muscle, Bone Marrow
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Publications for Hypertrophic Scars

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Articles related to Hypertrophic Scars:

(show top 50) (show all 1934)
# Title Authors PMID Year
1
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in patients with different types of scars and keloids. 54 61
19464975 2010
2
Pentoxifylline modifies three-dimensional collagen lattice model contraction and expression of collagen types I and III by human fibroblasts derived from post-burn hypertrophic scars and from normal skin. 54 61
19303218 2009
3
Nonlinear spectral imaging of human hypertrophic scar based on two-photon excited fluorescence and second-harmonic generation. 54 61
19309369 2009
4
Tranilast, an anti-allergic drug, down-regulates the growth of cultured neurofibroma cells derived from neurofibromatosis type 1. 61 54
19282654 2009
5
[Expression of Notch receptors, ligands and downstream target genes in epidermis of hypertrophic scar]. 61 54
19408725 2009
6
Hic-5 promotes the hypertrophic scar myofibroblast phenotype by regulating the TGF-beta1 autocrine loop. 54 61
18401422 2008
7
Expression of Smad protein by normal skin fibroblasts and hypertrophic scar fibroblasts in response to transforming growth factor beta1. 54 61
18616749 2008
8
TGF-beta1 slows the growth of pathogenic myofibroblasts through a mechanism requiring the focal adhesion protein, Hic-5. 61 54
17671518 2008
9
[Expression of matrix metalloproteinase-2, -9 and their inhibitor-1 in hypertrophic scars]. 54 61
18457258 2007
10
Basic fibroblast growth factor reduces scar formation in acute incisional wounds. 61 54
17971006 2007
11
Differential p63 and p53 expression in human keloid fibroblasts and hypertrophic scar fibroblasts. 61 54
17688405 2007
12
Upregulation of TGF-beta1 expression may be necessary but is not sufficient for excessive scarring. 61 54
16498396 2006
13
[Effect of asiaticoside on the expression of transforming growth factor-beta mRNA and matrix metalloproteinases in hypertrophic scars]. 61 54
16495179 2006
14
Upregulation of the Wnt/beta-catenin pathway induced by transforming growth factor-beta in hypertrophic scars and keloids. 54 61
16874413 2006
15
A basic fibroblast growth factor improved the quality of skin grafting in burn patients. 54 61
16199295 2005
16
Hypertrophic scar fibroblasts have increased connective tissue growth factor expression after transforming growth factor-beta stimulation. 61 54
16217483 2005
17
[A study of the abnormalities of human epiderm in keloids and hypertrophic scars]. 54 61
15363271 2004
18
Gene expression profiles from hypertrophic scar fibroblasts before and after IL-6 stimulation. 61 54
15095275 2004
19
Fibrillin-1 and elastin are differentially expressed in hypertrophic scars and keloids. 54 61
15086768 2004
20
[Distribution and expression of transforming growth factor beta and their receptors in hypertrophic scar]. 54 61
15059449 2004
21
Genetic susceptibility to keloid disease and hypertrophic scarring: transforming growth factor beta1 common polymorphisms and plasma levels. 61 54
12560674 2003
22
Intervention with tranilast attenuates renal pathology and albuminuria in advanced experimental diabetic nephropathy. 61 54
14694265 2003
23
[Experimental study of the expression of c-myc, c-fos and proto-oncogenes on hypertrophic and scars]. 54 61
12189705 2002
24
Release and activation of matrix metalloproteinase-9 during in vitro mechanical compression in hypertrophic scars. 61 54
11939809 2002
25
Detection of collagens in hypertrophic scars by picrosirius polarization method. 61 54
12390767 2002
26
[Change of gene expression of transforming growth factor-beta1, Smad 2 and Smad 3 in hypertrophic scars skins]. 54 61
11955370 2002
27
[Expression of alpha-smooth muscle actin in scar fibroblasts in vitro]. 54 61
11762220 2001
28
Expression of oncoproteins c-fos and c-jun in hypertrophic scars and chronic dermal ulcers and their regulation of basic fibroblast growth factor. 54 61
11780366 2001
29
Altered expression of keratins during abnormal wound healing in human skin. 61 54
11219730 2001
30
[The significance and characteristics of the gene expressions of c-fos and c-jun in hypertrophic scar and chronic ulcer tissues]. 61 54
11876891 2000
31
[Characteristics of bFGF and TGF-beta expression in dermal chronic ulcers and hypertrophic scars and their effects on tissue repair]. 61 54
12516473 2000
32
[A study on the expressions and the correlation of TGF-beta and alpha-SMA in scars]. 61 54
11593622 2000
33
Delayed appearance of decorin in healing burn scars. 61 54
10692030 2000
34
Expression of Bcl-2, p53, c-jun and c-fos protooncogenes in keloids and hypertrophic scars. 54 61
10651227 1999
35
Exogenous transforming growth factor beta(2) modulates collagen I and collagen III synthesis in proliferative scar xenografts in nude rats. 61 54
10600349 1999
36
Gelatinase activity in keloids and hypertrophic scars. 54 61
10417752 1999
37
Cytokine expression is downregulated by collagen-polyvinylpyrrolidone in hypertrophic scars. 61 54
9804346 1998
38
Transforming growth factor-beta in thermally injured patients with hypertrophic scars: effects of interferon alpha-2b. 61 54
9773986 1998
39
Hypertrophic scarring is associated with epidermal abnormalities: an immunohistochemical study. 61 54
9924436 1998
40
Activated keratinocytes in the epidermis of hypertrophic scars. 54 61
9588880 1998
41
Enhanced expression of transforming growth factor-beta type I and type II receptors in wound granulation tissue and hypertrophic scar. 61 54
9466575 1998
42
Primary ex vivo culture of keratinocytes isolated from hypertrophic scars as a means of biochemical characterization of CD36. 54 61
9594363 1998
43
Cytokine mRNA changes during the treatment of hypertrophic scars with silicone and nonsilicone gel dressings. 61 54
9063511 1996
44
[Comparative study of collagen in hypertrophic and keloid cicatrix]. 54 61
9139458 1996
45
Chemical characterization and quantification of proteoglycans in human post-burn hypertrophic and mature scars. 61 54
8665780 1996
46
Acceleration of wound healing in diabetic mice by basic fibroblast growth factor. 61 54
8860952 1996
47
Differential expression of IGFBPs by normal and hypertrophic scar fibroblasts. 54 61
8592408 1996
48
Immunohistochemical localization of the proteoglycans decorin, biglycan and versican and transforming growth factor-beta in human post-burn hypertrophic and mature scars. 54 61
7544762 1995
49
Modulation of collagen synthesis by transforming growth factor-beta in keloid and hypertrophic scar fibroblasts. 54 61
7979045 1994
50
Fibronectin gene expression differs in normal and abnormal human wound healing. 54 61
17168907 1994
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Variations for Hypertrophic Scars

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Expression for Hypertrophic Scars

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Search GEO for disease gene expression data for Hypertrophic Scars.
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Pathways for Hypertrophic Scars

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Pathways related to Hypertrophic Scars according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 63
Show member pathways
 13.66 TIMP1 TGFB3 TGFB1 SMAD3 SMAD2 BMP6
2
GPCR Pathway 63
Show member pathways
 13.49 TIMP1 TGFB3 TGFB1 SMAD3 SMAD2 MMP2
3
TGF-Beta Pathway 63
Show member pathways
 13.38 TIMP1 TGFB3 TGFB1 SMAD3 SMAD2 BMP6
4
Developmental Biology 65
Show member pathways
 13.35 TGFB1 SMAD3 SMAD2 MMP2 KRT16 CD36
5
PAK Pathway 63
Show member pathways
 13.16 TIMP1 TGFB3 TGFB1 SMAD3 BMP6
6
Phospholipase-C Pathway 63
Show member pathways
 12.93 TIMP1 TGFB3 TGFB1 BMP6
7
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 12.92 TGFB3 TGFB1 SMAD3 SMAD2
8
p70S6K Signaling 63
Show member pathways
 12.91 TIMP1 TGFB3 TGFB1 BMP6
9
Endometrial cancer 36
Show member pathways
 12.75 TGFB3 TGFB1 SMAD3 SMAD2
10
Pathways in cancer 36
12.69 TGFB3 TGFB1 SMAD3 SMAD2 MMP2
11
Gastric cancer 36
Show member pathways
 12.65 TGFB3 TGFB1 SMAD3 SMAD2
12
Degradation of the extracellular matrix 65
Show member pathways
 12.63 TIMP1 TGFB3 TGFB1 MMP2
13
NF-KappaB Family Pathway 63
Show member pathways
 12.59 TIMP1 TGFB3 TGFB1 BMP6
14
Relaxin signaling pathway 36
Show member pathways
 12.56 TGFB1 SMAD2 MMP2 KRT16
15
Th17 cell differentiation 36
Show member pathways
 12.49 TGFB3 TGFB1 SMAD3 SMAD2
16
Human Embryonic Stem Cell Pluripotency 63
Show member pathways
 12.37 TGFB3 TGFB1 SMAD3 SMAD2
17
G-protein signaling RAC1 in cellular process 22
Show member pathways
 12.29 TIMP1 TGFB3 TGFB1 BMP6
18
Cell cycle 36 1
12.26 TGFB3 TGFB1 SMAD3 SMAD2
19
Human T-cell leukemia virus 1 infection 36
12.23 TGFB3 TGFB1 SMAD3 SMAD2
20
Translation Non-genomic (rapid) action of Androgen Receptor 22
Show member pathways
 12.21 TGFB1 SMAD3 MMP2
21
Proteoglycans in cancer 36
12.2 TGFB1 SMAD2 MMP2
22
Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer 65
Show member pathways
 12.19 TGFB1 SMAD3 SMAD2
23
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.16 TIMP1 TGFB3 TGFB1 BMP6
24
Cell cycle Role of SCF complex in cell cycle regulation 22
Show member pathways
 12.13 TGFB1 SMAD3 SMAD2
25
Wnt / Hedgehog / Notch 4
12.11 TGFB3 TGFB1 SMAD3 SMAD2 BMP6
26
Cellular senescence (KEGG) 36
12.05 TGFB3 TGFB1 SMAD3 SMAD2
27
Colorectal Cancer Metastasis 63
12.02 TGFB3 TGFB1 SMAD3 SMAD2 MMP2
28
FoxO signaling pathway 36
Show member pathways
 12 TGFB3 TGFB1 SMAD3
29
TGF-beta Signaling Pathway (WikiPathways) 1
11.98 TGFB1 SMAD3 SMAD2
30
Hippo signaling pathway 36
11.96 TGFB3 TGFB1 SMAD3 SMAD2 BMP6
31
Interleukin-4 and 13 signaling 65
11.89 TIMP1 TGFB1 MMP2 CD36
32
Mesenchymal Stem Cells and Lineage-specific Markers 64
11.81 TGFB3 TGFB1 BMP6
33
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.8 TGFB1 SMAD3 SMAD2
34
TGF-beta Signaling Pathways 64
11.79 TGFB3 TGFB1 SMAD3 SMAD2
35
Th17 Differentiation 64
Show member pathways
 11.75 TGFB3 TGFB1 SMAD3 SMAD2
36
Angiogenesis (CST) 4
11.73 TIMP1 TGFB3 TGFB1 MMP2
37
SMAD2/3 MH2 Domain Mutants in Cancer 65
Show member pathways
 11.7 TGFB1 SMAD3 SMAD2
38
Development_TGF-beta receptor signaling 22
11.67 TGFB1 SMAD3 SMAD2
39
TGF-beta receptor signaling activates SMADs 65
Show member pathways
 11.65 TGFB1 SMAD3 SMAD2
40
G-protein signaling_RhoA regulation pathway 22
11.63 TIMP1 TGFB3 TGFB1 BMP6
41
AGE/RAGE pathway 1
11.61 SMAD3 SMAD2 MMP2
42
Lung fibrosis 1
11.59 TIMP1 TGFB1 MMP2
43
AGE-RAGE signaling pathway in diabetic complications 36
11.55 TGFB3 TGFB1 SMAD3 SMAD2 MMP2
44
TGF-beta Receptor Signaling (WikiPathways) 1
11.54 TGFB1 SMAD3 SMAD2
45
Malaria 36
11.46 TGFB3 TGFB1 CD36
46
TGF-beta receptor signaling (Pathway Interaction Database) 1
11.44 TGFB3 TGFB1 SMAD3 SMAD2
47
IL-2 Gene Expression in Activated and Quiescent T-Cells 63
Show member pathways
 11.41 TGFB3 TGFB1 SMAD3 SMAD2 MMP2
48
Integrated Cancer Pathway 1
11.39 SMAD3 SMAD2
49
TGF-beta signaling pathway (KEGG) 36
11.33 TGFB3 TGFB1 SMAD3 SMAD2 BMP6
50
IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types 64
Show member pathways
 11.28 TGFB3 TGFB1
Sources

GO Terms for Hypertrophic Scars

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Cellular components related to Hypertrophic Scars according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 TIMP1 TGFB3 TGFB1 MMP2 CD36 BMP6
2 extracellular matrix GO:0031012 9.5 TIMP1 TGFB1 MMP2
3 SMAD protein complex GO:0071141 9.16 SMAD3 SMAD2
4 platelet alpha granule lumen GO:0031093 9.13 TIMP1 TGFB3 TGFB1
5 heteromeric SMAD protein complex GO:0071144 8.62 SMAD3 SMAD2

Biological processes related to Hypertrophic Scars according to GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.1 TGFB3 TGFB1 SMAD3 SMAD2 BMP6
2 negative regulation of transcription by RNA polymerase II GO:0000122 10.07 TGFB1 SMAD3 SMAD2 CD36 BMP6
3 positive regulation of transcription, DNA-templated GO:0045893 10.02 TGFB3 TGFB1 SMAD3 SMAD2
4 positive regulation of cell proliferation GO:0008284 10.01 TIMP1 TGFB3 TGFB1 BMP6
5 negative regulation of cell proliferation GO:0008285 10 TGFB3 TGFB1 SMAD3 SMAD2
6 positive regulation of gene expression GO:0010628 9.97 TGFB1 SMAD3 SMAD2 CD36 BMP6
7 cytokine-mediated signaling pathway GO:0019221 9.94 TIMP1 TGFB1 MMP2 CD36
8 in utero embryonic development GO:0001701 9.9 TGFB3 SMAD3 SMAD2
9 aging GO:0007568 9.88 TIMP1 TGFB3 TGFB1 KRT16
10 response to hypoxia GO:0001666 9.87 TGFB3 TGFB1 SMAD3 MMP2
11 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.83 TGFB1 CD36 BMP6
12 BMP signaling pathway GO:0030509 9.83 TGFB3 TGFB1 BMP6
13 platelet degranulation GO:0002576 9.8 TIMP1 TGFB3 TGFB1 CD36
14 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.78 TGFB3 TGFB1 BMP6
15 positive regulation of protein secretion GO:0050714 9.77 TGFB3 TGFB1 BMP6
16 ureteric bud development GO:0001657 9.77 TGFB1 SMAD3 SMAD2
17 transforming growth factor beta receptor signaling pathway GO:0007179 9.76 TGFB3 TGFB1 SMAD3 SMAD2
18 extrinsic apoptotic signaling pathway GO:0097191 9.74 TGFB1 SMAD3
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.74 SMAD3 CD36
20 response to progesterone GO:0032570 9.74 TGFB3 TGFB1
21 positive regulation of protein import into nucleus GO:0042307 9.73 TGFB1 SMAD3
22 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.73 TGFB1 SMAD3
23 negative regulation of mitotic cell cycle GO:0045930 9.73 TGFB1 SMAD3
24 mesoderm formation GO:0001707 9.73 SMAD3 SMAD2
25 gastrulation GO:0007369 9.73 SMAD3 SMAD2
26 embryonic cranial skeleton morphogenesis GO:0048701 9.73 SMAD3 SMAD2
27 mammary gland development GO:0030879 9.72 TGFB3 TGFB1
28 digestive tract development GO:0048565 9.72 TGFB3 TGFB1
29 developmental growth GO:0048589 9.72 SMAD3 SMAD2
30 embryonic pattern specification GO:0009880 9.71 SMAD3 SMAD2
31 positive regulation of collagen biosynthetic process GO:0032967 9.71 TGFB3 TGFB1
32 adrenal gland development GO:0030325 9.71 SMAD3 SMAD2
33 face morphogenesis GO:0060325 9.71 TGFB3 TGFB1 MMP2
34 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.71 TGFB3 TGFB1 SMAD3 SMAD2
35 signal transduction involved in regulation of gene expression GO:0023019 9.7 SMAD3 SMAD2
36 activin receptor signaling pathway GO:0032924 9.7 SMAD3 SMAD2
37 positive regulation of chondrocyte differentiation GO:0032332 9.7 SMAD3 BMP6
38 endoderm development GO:0007492 9.7 TGFB1 SMAD3 SMAD2
39 secondary palate development GO:0062009 9.69 TGFB3 SMAD2
40 lens fiber cell differentiation GO:0070306 9.69 TGFB1 SMAD3
41 cell activation GO:0001775 9.69 TIMP1 TGFB1
42 regulation of transforming growth factor beta receptor signaling pathway GO:0017015 9.69 TGFB1 SMAD3 SMAD2
43 positive regulation of vascular permeability GO:0043117 9.68 TGFB1 BMP6
44 response to cholesterol GO:0070723 9.68 TGFB1 SMAD2
45 nodal signaling pathway GO:0038092 9.68 SMAD3 SMAD2
46 primary miRNA processing GO:0031053 9.68 SMAD3 SMAD2
47 salivary gland morphogenesis GO:0007435 9.67 TGFB3 TGFB1
48 pericardium development GO:0060039 9.67 SMAD3 SMAD2
49 embryonic foregut morphogenesis GO:0048617 9.66 SMAD3 SMAD2
50 response to laminar fluid shear stress GO:0034616 9.65 TGFB3 TGFB1

Molecular functions related to Hypertrophic Scars according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.62 TIMP1 TGFB3 TGFB1 BMP6
2 transforming growth factor beta binding GO:0050431 9.51 TGFB3 CD36
3 R-SMAD binding GO:0070412 9.49 SMAD3 SMAD2
4 enhancer binding GO:0035326 9.48 SMAD3 SMAD2
5 co-SMAD binding GO:0070410 9.46 SMAD3 SMAD2
6 growth factor activity GO:0008083 9.46 TIMP1 TGFB3 TGFB1 BMP6
7 primary miRNA binding GO:0070878 9.43 SMAD3 SMAD2
8 type II transforming growth factor beta receptor binding GO:0005114 9.4 TGFB3 TGFB1
9 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618 9.37 SMAD3 SMAD2
10 type III transforming growth factor beta receptor binding GO:0034714 9.26 TGFB3 TGFB1
11 type I transforming growth factor beta receptor binding GO:0034713 9.13 TGFB3 TGFB1 SMAD2
12 transforming growth factor beta receptor binding GO:0005160 8.92 TGFB3 TGFB1 SMAD3 SMAD2
Sources

Sources for Hypertrophic Scars

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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