MCID: HYP078
MIFTS: 31

Hypertrophy of Breast

Categories: Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Hypertrophy of Breast

MalaCards integrated aliases for Hypertrophy of Breast:

Name: Hypertrophy of Breast 12 15
Breasts Enlarged 12
Large Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10688
ICD10 33 N62
ICD9CM 35 611.1
NCIt 50 C3125
SNOMED-CT 68 43336006
UMLS 73 C0020565

Summaries for Hypertrophy of Breast

Disease Ontology : 12 A breast disease that is characterized by the progressive, excessive enlargement of breast connective tissue.

MalaCards based summary : Hypertrophy of Breast, also known as breasts enlarged, is related to aromatase excess syndrome and hypertrophy of the breast, juvenile. An important gene associated with Hypertrophy of Breast is ARFGEF1 (ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 1). The drugs Acetylcysteine and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and skin, and related phenotype is renal/urinary system.

Wikipedia : 76 Breast hypertrophy is a rare medical condition of the breast connective tissues in which the breasts... more...

Related Diseases for Hypertrophy of Breast

Diseases in the Hypertrophy of Breast family:

Hypertrophy of the Breast, Juvenile

Diseases related to Hypertrophy of Breast via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
# Related Disease Score Top Affiliating Genes
1 aromatase excess syndrome 10.9
2 hypertrophy of the breast, juvenile 10.3
3 gynecomastia 10.3
4 pseudoangiomatous stromal hyperplasia 10.1
5 lactocele 9.9
6 galactorrhea 9.7
7 ahumada del castillo syndrome 9.7
8 myasthenia gravis 9.7
9 hyperprolactinemia 9.7
10 breast fibroadenoma 9.7
11 t-cell leukemia 9.7
12 mediastinitis 9.7
13 fibrosing mediastinitis 9.7
14 lipoblastoma 9.7
15 myasthenia gravis congenital 9.7
16 breast cancer 9.5
17 lipomatosis, multiple 9.5
18 ovarian cancer 9.5
19 breast abscess 9.5
20 pleomorphic lipoma 9.5
21 breast lipoma 9.5
22 infiltrating lipoma 9.5
23 gigantomastia 9.5

Graphical network of the top 20 diseases related to Hypertrophy of Breast:



Diseases related to Hypertrophy of Breast

Symptoms & Phenotypes for Hypertrophy of Breast

MGI Mouse Phenotypes related to Hypertrophy of Breast:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.92 BRCA1 CNTRL PGAP3 SCLT1

Drugs & Therapeutics for Hypertrophy of Breast

Drugs for Hypertrophy of Breast (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
2 Pharmaceutical Solutions Phase 4,Not Applicable
3 Antiviral Agents Phase 4
4 Anti-Infective Agents Phase 4
5 Free Radical Scavengers Phase 4
6 Expectorants Phase 4
7 Respiratory System Agents Phase 4
8 Antioxidants Phase 4
9 Antidotes Phase 4
10 N-monoacetylcystine Phase 4
11 Protective Agents Phase 4
12
Dutasteride Approved, Investigational Phase 3 164656-23-9 6918296 152945
13
Spironolactone Approved Phase 3 52-01-7, 1952-01-7 5833
14 Steroid Synthesis Inhibitors Phase 3,Phase 1
15 Hormones Phase 3,Phase 1
16 Hormone Antagonists Phase 3,Phase 1
17 5-alpha Reductase Inhibitors Phase 3
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1
19 diuretics Phase 3
20 Calcium, Dietary Phase 3
21 Mineralocorticoids Phase 3
22 Diuretics, Potassium Sparing Phase 3
23 Natriuretic Agents Phase 3
24 Mineralocorticoid Receptor Antagonists Phase 3
25
Testolactone Approved, Investigational Phase 2 968-93-4 13769
26 Estrogens Phase 2,Phase 1
27 Aromatase Inhibitors Phase 2,Phase 1
28 Antineoplastic Agents, Hormonal Phase 2
29
Letrozole Approved, Investigational Phase 1 112809-51-5 3902
30 Estrogen Antagonists Phase 1
31 Estrogen Receptor Antagonists Phase 1
32
Bupivacaine Approved, Investigational Not Applicable 2180-92-9, 38396-39-3 2474
33
Racepinephrine Approved Not Applicable 329-65-7 838
34
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
35
Povidone Approved Not Applicable 9003-39-8
36
Iodine Approved, Investigational Not Applicable 7553-56-2 807
37
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
38
Povidone-iodine Approved Not Applicable 25655-41-8
39
Morphine Approved, Investigational Not Applicable 57-27-2 5288826
40
Acetaminophen Approved Not Applicable 103-90-2 1983
41
Meperidine Approved Not Applicable 57-42-1 4058
42 Epinephryl borate Not Applicable
43 Central Nervous System Depressants Not Applicable
44 Anesthetics Not Applicable
45 Anesthetics, Local Not Applicable
46 Analgesics, Opioid Not Applicable
47 Peripheral Nervous System Agents Not Applicable
48 Narcotics Not Applicable
49 Analgesics Not Applicable
50 Anti-Infective Agents, Local Not Applicable

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 The Impact of N-Acetylcysteine on Volumetric Retention of Autologous Fat Graft for Breast Asymmetry Correction Active, not recruiting NCT03197103 Phase 4 N-Acetylcysteine (NAC)
2 CPG Styles Study: A Study of the Safety of the Contour Profile Gel Breast Implants (CPG Styles Study) Completed NCT01959880 Phase 3
3 Core Gel Study of the Safety and Effectiveness of Mentor Round Low Bleed Silicone Gel-filled Mammary Prostheses Completed NCT00753922 Phase 3
4 Mentor Siltex® Contour Profile Gel Mammary Prosthesis Clinical Trial Completed NCT00812097 Phase 3
5 Sexual Function in Men Receiving Dutasteride for Androgenetic Alopecia Completed NCT02014584 Phase 3 Dutasteride;Placebo
6 Prevention of the Progression of Coronary Calcification With Use of Spironolactone in Peritoneal Dialysis Patients Completed NCT03314493 Phase 3 Spironolactone 25Mg Tablet
7 Spectra Breast Implant Study Withdrawn NCT00981266 Phase 3
8 Testolactone for the Treatment of Girls With LHRH Resistant Precocious Puberty Completed NCT00001181 Phase 2 Testolactone
9 Effects of Letrozole on Precocious Puberty Due to McCune Albright Syndrome Completed NCT00006174 Phase 1 Letrozole
10 Postural Control in Breast Hypertrophy Completed NCT01519024
11 Physical Activity and Sexuality After Reduction Mammaplasty Completed NCT01297621 Not Applicable
12 Sexuality After Reduction Mammaplasty Completed NCT01020422 Not Applicable
13 Quality of Life Among Breast Reduction Patients Completed NCT00149370
14 Comparison of Superomedial and Inferior Pedicle Techniques in Mammaplasty Completed NCT03669679 Not Applicable
15 Vertical Scar Versus Inferior Pedicle Reduction Mammoplasty Completed NCT00149344 Not Applicable
16 Ultrasound Guided Bilateral Erector Spinae Plane Block Versus Tumescent Anesthesia Completed NCT03558880 Not Applicable
17 Randomized Controlled Trial of Subcuticular Skin Closure Versus Steri-strip S Closure Completed NCT00727025 Not Applicable
18 Cost-effectiveness of Reduction Mammaplasty Completed NCT00992368 Not Applicable
19 Dressing Wear Time After Reduction Mammaplasty Completed NCT01002391 Not Applicable
20 White Light Scanning to Aid Body Contouring: A Pilot Project Recruiting NCT01093950
21 Bilateral Ultrasound-Guided Erector Spinae Plane Block For Postoperative Analgesia in Breast Reduction Surgery Not yet recruiting NCT03621345 Not Applicable
22 UltraShape Device for Non-Invasive Fat Reduction in the Male Breast (Pseudogynecomastia) Withdrawn NCT02711605 Not Applicable

Search NIH Clinical Center for Hypertrophy of Breast

Genetic Tests for Hypertrophy of Breast

Anatomical Context for Hypertrophy of Breast

MalaCards organs/tissues related to Hypertrophy of Breast:

41
Breast, Lymph Node, Skin, Testes, T Cells

Publications for Hypertrophy of Breast

Articles related to Hypertrophy of Breast:

# Title Authors Year
1
Intramuscular lipoma originating in pectoralis major: A rare presentation of a large breast mass. ( 30488585 )
2018
2
Survival of patients with de-novo metastatic breast cancer: analysis of data from a large breast cancer-specific private practice, a university-based cancer center and review of the literature. ( 26358708 )
2015
3
Evaluation of RAD51C as cancer susceptibility gene in a large breast-ovarian cancer patient population referred for genetic testing. ( 22370629 )
2012
4
Extremely large breast abscess in a breastfeeding mother. ( 22596060 )
2012
5
Genetic analysis of the BRCA1 region in a large breast/ovarian family: refinement of the minimal region containing BRCA1. ( 8281142 )
1993
6
An unusually large breast lipoma. ( 18119433 )
1949
7
Gigantomastia; the two-stage operation for reduction of extremely large breast vs the one-stage technique. ( 18134474 )
1949

Variations for Hypertrophy of Breast

Expression for Hypertrophy of Breast

Search GEO for disease gene expression data for Hypertrophy of Breast.

Pathways for Hypertrophy of Breast

GO Terms for Hypertrophy of Breast

Biological processes related to Hypertrophy of Breast according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ciliary basal body-plasma membrane docking GO:0097711 8.62 CNTRL SCLT1

Sources for Hypertrophy of Breast

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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