MCID: HYP078
MIFTS: 41

Hypertrophy of Breast

Categories: Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Hypertrophy of Breast

MalaCards integrated aliases for Hypertrophy of Breast:

Name: Hypertrophy of Breast 12 15 32
Breasts Enlarged 12
Large Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10688
ICD9CM 34 611.1
NCIt 50 C3125
SNOMED-CT 67 43336006
ICD10 32 N62
UMLS 71 C0020565

Summaries for Hypertrophy of Breast

Disease Ontology : 12 A breast disease that is characterized by the progressive, excessive enlargement of breast connective tissue.

MalaCards based summary : Hypertrophy of Breast, also known as breasts enlarged, is related to gynecomastia and intraductal papilloma. An important gene associated with Hypertrophy of Breast is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Pathways in cancer and Development HGF signaling pathway. The drugs Doxorubicin and Epirubicin have been mentioned in the context of this disorder. Affiliated tissues include breast, skin and lymph node, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Wikipedia : 74 Breast hypertrophy is a rare medical condition of the breast connective tissues in which the breasts... more...

Related Diseases for Hypertrophy of Breast

Diseases in the Hypertrophy of Breast family:

Hypertrophy of the Breast, Juvenile

Diseases related to Hypertrophy of Breast via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 221)
# Related Disease Score Top Affiliating Genes
1 gynecomastia 30.5 PGR ESR1 ERBB2 CYP19A1
2 intraductal papilloma 30.1 PGR ESR1 ERBB2
3 breast-ovarian cancer, familial 2 29.9 BRCA2 BRCA1
4 mammographic density 29.9 ESR1 CYP19A1
5 lobular neoplasia 29.5 TP53 PGR ESR1 ERBB2 BRCA2 BRCA1
6 bilateral breast cancer 29.4 PIK3CA PGR ESR1 ERBB2 BRCA2 BRCA1
7 breast fibroadenoma 29.3 TP53 PGR ESR1 ERBB2 CYP19A1 BRCA1
8 in situ carcinoma 29.2 TP53 PIK3CA PGR ESR1 ERBB2 CYP19A1
9 ductal carcinoma in situ 29.1 TP53 PIK3CA PGR ESR1 ERBB2 CYP19A1
10 ovarian cancer 28.4 TP53 PIK3CA PGR MIR10B MAP3K1 ESR1
11 bartholin's gland adenoid cystic carcinoma 10.4 PGR ESR1
12 uterine corpus adenosarcoma 10.4 PGR ESR1
13 chronic tympanitis 10.4 PGR ESR1
14 granulomatous endometritis 10.4 PGR ESR1
15 vulvar syringoma 10.4 PGR ESR1
16 scirrhous adenocarcinoma 10.4 PGR ERBB2
17 lipid-rich breast carcinoma 10.4 PGR ERBB2
18 fallopian tube clear cell adenocarcinoma 10.4 BRCA2 BRCA1
19 breast squamous cell carcinoma 10.4 ESR1 ERBB2
20 lung leiomyoma 10.4 PGR ESR1
21 adult type testicular granulosa cell tumor 10.4 PGR ESR1
22 cervical clear cell adenocarcinoma 10.4 PGR ESR1
23 cancerophobia 10.4 BRCA2 BRCA1
24 ovary transitional cell carcinoma 10.4 BRCA2 BRCA1
25 nosophobia 10.4 BRCA2 BRCA1
26 luminal breast carcinoma b 10.4 PGR ERBB2
27 hereditary site-specific ovarian cancer syndrome 10.4 BRCA2 BRCA1
28 tetraploidy 10.4 BRCA2 BRCA1
29 glassy cell carcinoma of the cervix 10.4 PGR ESR1 ERBB2
30 breast intraductal papillomatosis 10.4 PGR ESR1 ERBB2
31 nipple carcinoma 10.4 PGR ESR1 ERBB2
32 liver leiomyoma 10.4 PGR ESR1
33 breast scirrhous carcinoma 10.4 PGR ESR1 ERBB2
34 oncocytic breast carcinoma 10.4 PGR ESR1 ERBB2
35 b-lymphoblastic leukemia/lymphoma with hyperdiploidy 10.4 BRCA2 BRCA1
36 breast papillary carcinoma 10.4 PGR ESR1 ERBB2
37 papillary carcinoma 10.4 PGR ESR1 ERBB2
38 breast adenoid cystic carcinoma 10.4 PGR ESR1 ERBB2
39 breast metaplastic carcinoma 10.4 PGR ESR1 ERBB2
40 intravenous leiomyomatosis 10.4 PGR ESR1
41 breast mucinous carcinoma 10.4 PGR ERBB2
42 lipid-rich carcinoma 10.4 PGR ESR1 ERBB2
43 progesterone-receptor negative breast cancer 10.4 PGR ESR1 ERBB2
44 breast osteosarcoma 10.4 PGR ESR1 ERBB2
45 apocrine sweat gland neoplasm 10.4 PGR ESR1 ERBB2
46 intracranial meningioma 10.3 PGR ESR1
47 retinitis pigmentosa 47 10.3 PGR ESR1 ERBB2
48 inflammatory breast carcinoma 10.3 PGR ESR1 ERBB2
49 gastric papillary adenocarcinoma 10.3 TP53 ERBB2
50 familial ovarian cancer 10.3 ESR1 BRCA2 BRCA1

Graphical network of the top 20 diseases related to Hypertrophy of Breast:



Diseases related to Hypertrophy of Breast

Symptoms & Phenotypes for Hypertrophy of Breast

MGI Mouse Phenotypes related to Hypertrophy of Breast:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.97 BRCA1 BRCA2 CUEDC2 CYP19A1 ERBB2 ESR1
2 endocrine/exocrine gland MP:0005379 9.97 BRCA1 BRCA2 CYP19A1 ERBB2 ESR1 GATA3
3 integument MP:0010771 9.96 BRCA1 BRCA2 CYP19A1 ERBB2 ESR1 GATA3
4 muscle MP:0005369 9.81 BRCA1 CYP19A1 ERBB2 ESR1 GATA3 MAP3K1
5 neoplasm MP:0002006 9.61 BRCA1 BRCA2 CUEDC2 ERBB2 ESR1 MAP3K1
6 skeleton MP:0005390 9.32 BRCA1 BRCA2 CYP19A1 ERBB2 ESR1 GATA3

Drugs & Therapeutics for Hypertrophy of Breast

Drugs for Hypertrophy of Breast (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
2
Epirubicin Approved Phase 3 56420-45-2 41867
3 Antibiotics, Antitubercular Phase 3
4 Immunologic Factors Phase 3
5 Antirheumatic Agents Phase 3
6 Anti-Bacterial Agents Phase 3
7
Liposomal doxorubicin Phase 3 31703
8 Alkylating Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Pivotal Trial to Assess the Safety and Efficacy of Preoperative Focused Microwave Thermotherapy Plus Preoperative Chemotherapy Versus Preoperative Chemotherapy Alone for Cytoreduction of Large Breast Cancer in Female Patients With Intact Breast Unknown status NCT01204801 Phase 3 Chemotherapy (control)
2 Randomized Controlled Trial Comparing Prone and Supine Intensity-modulated Radiotherapy (IMRT) After Breast-conserving Surgery in Patients With Large Breast Volume at High Risk for Skin Toxicity and Fibrosis Unknown status NCT00887523
3 A Multicentre Randomized Controlled Clinical Trial for the Reduction of Acute Skin Reaction in Adjuvant Breast Radiation in Large Breasted Women Using a Prone Technique - The Prone Breast Trial Completed NCT01815476
4 Reduction of Breast Enlargement Using the Da Vinci Xi Robot Recruiting NCT04597515

Search NIH Clinical Center for Hypertrophy of Breast

Genetic Tests for Hypertrophy of Breast

Anatomical Context for Hypertrophy of Breast

MalaCards organs/tissues related to Hypertrophy of Breast:

40
Breast, Skin, Lymph Node, Brain

Publications for Hypertrophy of Breast

Articles related to Hypertrophy of Breast:

(show top 50) (show all 445)
# Title Authors PMID Year
1
CHRNA5 belongs to the secondary estrogen signaling network exhibiting prognostic significance in breast cancer. 61
33469842 2021
2
Relationship of breast volume, obesity and central obesity with different prognostic factors of breast cancer. 61
33479372 2021
3
Carcinoma Breast-Like Giant Complex Fibroadenoma: A Clinical Masquerade. 61
33585101 2021
4
Is prone free breathing better than supine deep inspiration breath-hold for left whole-breast radiotherapy? A dosimetric analysis. 61
33416915 2021
5
Mate Choice in Double-Breeding Female Great Tits (Parus Major): Good Males or Compatible Males. 61
33440643 2021
6
Double Layer Reconstruction of Exposed Cardiac Implantable Electronic Devices in Elderly Patients. 61
33542888 2021
7
Predicting adherence of dose-volume constraints for personalized partial-breast irradiation technique. 61
32741559 2021
8
5-year outcomes of a randomized trial comparing prone and supine whole breast irradiation in large breasted women. 61
33508375 2021
9
Skin Toxicity in Early Breast Cancer Patients Treated with Field-In-Field Breast Intensity-Modulated Radiotherapy versus Helical Inverse Breast Intensity-Modulated Radiotherapy: Results of a Phase III Randomised Controlled Trial. 61
32711920 2021
10
Optimization of Wire-guided Technique With Bracketing Reduces Resection Volumes in Breast-conserving Surgery for Early Breast Cancer. 61
32653472 2020
11
Identification Of Differentially Expressed Gene Modules In Heterogeneous Diseases. 61
33325506 2020
12
Spiral breast computed tomography (CT): signal-to-noise and dose optimization using 3D-printed phantoms. 61
33263161 2020
13
[The Breast Cancer Cohort Study in Chinese Women: research design and preliminary results of clinical multi-center cohort]. 61
33378815 2020
14
Analysis of cardiac substructure dose in a large, multi-centre danish breast cancer cohort (the DBCG HYPO trial): Trends and predictive modelling. 61
32916238 2020
15
Multidimensional Machine Learning Personalized Prognostic Model in an Early Invasive Breast Cancer Population-Based Cohort in China: Algorithm Validation Study. 61
33164899 2020
16
Large breast lump with bloody nipple discharge: benign intraductal papilloma. 61
33148555 2020
17
Primary Breast Augmentation with Autologous Fat Grafting Alone: Evaluation of Patient Satisfaction Using the BREAST-Q. 61
31912145 2020
18
Comparison of complications according to incision types in nipple-sparing mastectomy and immediate reconstruction. 61
32653836 2020
19
Deep Learning Pre-training Strategy for Mammogram Image Classification: an Evaluation Study. 61
32607908 2020
20
Unilateral autologous breast reconstruction with unipedicled and bipedicled deep inferior epigastric artery perforator flap: A review of 168 cases over 3 years. 61
32384219 2020
21
"Bifidus pedicle", The Use of Bilobed Superomedial Pedicle for Breast Reshaping Following Upper Outer Quadrantectomy: A New Oncoplastic Breast Surgery Technique. 61
32978658 2020
22
Evaluation of glucocorticoid-induced TNF receptor (GITR) expression in breast cancer and across multiple tumor types. 61
32350416 2020
23
Scar Assessment After Breast Reconstruction: Risk Factors for Hypertrophy and Hyperpigmentation in Asian Patients. 61
32032113 2020
24
Lesion Detectability and Radiation Dose in Spiral Breast CT With Photon-Counting Detector Technology: A Phantom Study. 61
32209815 2020
25
Giant benign phyllodes breast tumour with pulmonary nodule mimicking malignancy: A case report. 61
32913869 2020
26
Correlation of hot spot to breast separation in patients treated with postlumpectomy tangent 3D-CRT using field-in-field technique and mixed photon energies. 61
31521451 2020
27
Effects of kV, filtration, dose, and object size on soft tissue and iodine contrast in dedicated breast CT. 61
32233091 2020
28
Paradoxical scintigraphy bone scan findings with malignancy-associated extreme hypercalcemia. 61
32212186 2020
29
Breast cancer risk prediction models and subsequent tumor characteristics. 61
32056079 2020
30
Breast reconstruction using a laparoscopically harvested pedicled omental flap after endoscopic mastectomy for patients with breast cancer: an observational study of a minimally invasive method. 61
32775257 2020
31
Negative-Pressure Suction Cannula for Treatment of Lactational Residual Milk Cavity: A Case Series Study. 61
32311281 2020
32
The feasibility of ultrasound-guided vacuum-assisted evacuation of large breast hematomas. 61
32598321 2020
33
Extensive Florid Lobular carcinoma in situ presenting as a large breast mass requiring a mastectomy. 61
31793132 2020
34
Clinical Characteristics and Outcomes of Single Versus Double Hormone Receptor-Positive Breast Cancer in 2 Large Databases. 61
31551181 2020
35
A fluence modulation and scatter shielding apparatus for dedicated breast CT: Theory of operation. 61
31955431 2020
36
Breast reconstruction after nipple-sparing mastectomy in the large and/or ptotic breast: A systematic review of indications, techniques, and outcomes. 61
31987776 2020
37
Dosimetric consequences of image guidance techniques on robust optimized intensity-modulated proton therapy for treatment of breast Cancer. 61
32103762 2020
38
Changes in DNA Damage Repair Gene Expression and Cell Cycle Gene Expression Do Not Explain Radioresistance in Tamoxifen-Resistant Breast Cancer. 61
31046897 2020
39
Spectrum and clinical relevance of PALB2 germline mutations in 7657 Chinese BRCA1/2-negative breast cancer patients. 61
31768816 2020
40
The Adventure of Axillary Treatment in Early Stage Breast Cancer. 61
31912008 2020
41
Primary amyloidosis of the breast excised using an oncoplastic reduction approach. 61
32310153 2020
42
Integrin α11β1 is expressed in breast cancer stroma and associates with aggressive tumor phenotypes. 61
31605508 2020
43
Do Men and Women in Saudi Arabia Have the Same Level of Awareness and Knowledge of Breast Cancer? A Cross-Sectional Study. 61
33116815 2020
44
Blood Gas Disturbances and Disproportionate Body Weight Distribution in Broilers With Wooden Breast. 61
32317988 2020
45
Impact of deviation from guideline recommended treatment on breast cancer survival in Asia. 61
31992769 2020
46
Intrathoracic Breast Transposition: A New Method in the Treatment of Bronchopleural Fistula and Empyema. 61
32537290 2019
47
EBADIMEX: an empirical Bayes approach to detect joint differential expression and methylation and to classify samples. 61
31734658 2019
48
Does Staged Breast Reduction before Nipple-Sparing Mastectomy Decrease Complications? A Matched Cohort Study between Staged and Nonstaged Techniques. 61
31373992 2019
49
Visualized oncoplastic surgery of the breast I: inferior and medial quadrantectomy. 61
31709168 2019
50
Surgery of nonpalpable breast cancer: First step to a virtual per-operative localization? First step to virtual breast cancer localization. 61
31179597 2019

Variations for Hypertrophy of Breast

Expression for Hypertrophy of Breast

Search GEO for disease gene expression data for Hypertrophy of Breast.

Pathways for Hypertrophy of Breast

Pathways related to Hypertrophy of Breast according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1 12.69 TP53 PIK3CA ESR1 ERBB2 BRCA2
2
Show member pathways
12.54 TP53 PIK3CA MAP3K1 ESR1 ERBB2
3
Show member pathways
12.53 TP53 MAP3K1 ESR1 BRCA2 BRCA1
4
Show member pathways
12.4 TP53 PIK3CA ESR1 ERBB2 BRCA2 BRCA1
5 12.37 TP53 PIK3CA MIR10B ERBB2 BRCA1
6
Show member pathways
12.24 PIK3CA MAP3K1 ESR1 BRCA1
7 12.08 TP53 PIK3CA MIR10B ESR1 ERBB2
8
Show member pathways
11.83 TP53 PIK3CA PGR ESR1 ERBB2 BRCA2
9 11.79 TP53 PIK3CA MAP3K1 ERBB2
10
Show member pathways
11.74 PIK3CA PGR ESR1 ERBB2
11
Show member pathways
11.65 TP53 BRCA2 BRCA1
12 11.56 TP53 PIK3CA ERBB2
13 11.54 TP53 ESR1 CYP19A1 BRCA2 BRCA1
14 11.42 TP53 PIK3CA ERBB2 BRCA1
15 11.28 TP53 PIK3CA ERBB2 BRCA1
16 11.14 TP53 MAP3K1 BRCA1
17 10.1 ESR1 CYP19A1

GO Terms for Hypertrophy of Breast

Cellular components related to Hypertrophy of Breast according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lateral element GO:0000800 8.62 BRCA2 BRCA1

Biological processes related to Hypertrophy of Breast according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 10.08 ZNF764 ZNF695 TP53 PGR GATA3 ESR1
2 protein deubiquitination GO:0016579 9.84 TP53 GATA3 ESR1 BRCA1
3 positive regulation of protein kinase B signaling GO:0051897 9.67 PIK3CA GATA3 ESR1 ERBB2
4 double-strand break repair GO:0006302 9.61 TP53 BRCA2 BRCA1
5 response to estrogen GO:0043627 9.58 GATA3 ESR1 BRCA1
6 uterus development GO:0060065 9.55 GATA3 ESR1
7 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.52 TP53 ESR1
8 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.51 TP53 ESR1
9 intracellular steroid hormone receptor signaling pathway GO:0030518 9.49 PGR ESR1
10 positive regulation of histone H3-K9 acetylation GO:2000617 9.46 GATA3 BRCA1
11 phosphatidylinositol 3-kinase signaling GO:0014065 9.33 PIK3CA GATA3 ERBB2
12 chordate embryonic development GO:0043009 9.32 BRCA2 BRCA1
13 negative regulation of mammary gland epithelial cell proliferation GO:0033600 9.26 GATA3 BRCA2
14 response to gamma radiation GO:0010332 9.13 TP53 GATA3 BRCA2
15 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 8.8 TP53 BRCA2 BRCA1

Molecular functions related to Hypertrophy of Breast according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.1 TP53 PGR MAP3K1 GATA3 ESR1 BRCA1

Sources for Hypertrophy of Breast

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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