MCID: HYP078
MIFTS: 27

Hypertrophy of Breast

Categories: Reproductive diseases, Rare diseases, Genetic diseases

Aliases & Classifications for Hypertrophy of Breast

MalaCards integrated aliases for Hypertrophy of Breast:

Name: Hypertrophy of Breast 12 15
Breasts Enlarged 12
Large Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10688
ICD10 33 N62
ICD9CM 35 611.1
NCIt 50 C3125
UMLS 73 C0020565

Summaries for Hypertrophy of Breast

MalaCards based summary : Hypertrophy of Breast, also known as breasts enlarged, is related to aromatase excess syndrome and hypertrophy of the breast, juvenile. An important gene associated with Hypertrophy of Breast is ARFGEF1 (ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 1). The drugs Acetylcysteine and Respiratory System Agents have been mentioned in the context of this disorder. Affiliated tissues include breast and skin, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Breast hypertrophy is a rare medical condition of the breast connective tissues in which the breasts... more...

Related Diseases for Hypertrophy of Breast

Diseases in the Hypertrophy of Breast family:

Hypertrophy of the Breast, Juvenile

Diseases related to Hypertrophy of Breast via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 aromatase excess syndrome 10.8
2 hypertrophy of the breast, juvenile 10.2
3 gynecomastia 10.2
4 pseudoangiomatous stromal hyperplasia 10.0
5 galactorrhea 9.6
6 ahumada del castillo syndrome 9.6
7 myasthenia gravis 9.6
8 hyperprolactinemia 9.6
9 leukemia 9.6
10 hypospadias 9.6
11 intraductal papilloma 9.6
12 fibrosing mediastinitis 9.6
13 breast cancer 9.4
14 ovarian cancer 9.4
15 breast lipoma 9.4
16 gigantomastia 9.4

Graphical network of the top 20 diseases related to Hypertrophy of Breast:



Diseases related to Hypertrophy of Breast

Symptoms & Phenotypes for Hypertrophy of Breast

GenomeRNAi Phenotypes related to Hypertrophy of Breast according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.36 BRCA1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.36 BRCA1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.36 BRCA1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.36 CNTRL
5 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.36 BRCA1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.36 BRCA1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.36 BRCA1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.36 BRCA1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.36 CNTRL
10 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.36 BRCA1 CNTRL

Drugs & Therapeutics for Hypertrophy of Breast

Drugs for Hypertrophy of Breast (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
2 Respiratory System Agents Phase 4
3 N-monoacetylcystine Phase 4
4 Pharmaceutical Solutions Phase 4
5 Expectorants Phase 4
6 Antidotes Phase 4
7 Anti-Infective Agents Phase 4
8 Antioxidants Phase 4
9 Protective Agents Phase 4
10 Antiviral Agents Phase 4
11
Spironolactone Approved Phase 3 1952-01-7, 52-01-7 5833
12
Dutasteride Approved, Investigational Phase 3 164656-23-9 152945 6918296
13 diuretics Phase 3
14 5-alpha Reductase Inhibitors Phase 3
15 Mineralocorticoid Receptor Antagonists Phase 3
16 Mineralocorticoids Phase 3
17 Natriuretic Agents Phase 3
18 Steroid Synthesis Inhibitors Phase 3,Phase 1
19 Hormone Antagonists Phase 3,Phase 1
20 Hormones Phase 3,Phase 1
21 Diuretics, Potassium Sparing Phase 3
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1
23 Calcium, Dietary Phase 3
24
Testolactone Approved, Investigational Phase 2 968-93-4 13769
25 Estrogens Phase 2,Phase 1
26 Aromatase Inhibitors Phase 2,Phase 1
27 Antineoplastic Agents, Hormonal Phase 2
28
Letrozole Approved, Investigational Phase 1 112809-51-5 3902
29 Estrogen Antagonists Phase 1

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 The Impact of N-Acetylcysteine on Volumetric Retention of Autologous Fat Graft for Breast Asymmetry Correction Active, not recruiting NCT03197103 Phase 4 N-Acetylcysteine (NAC)
2 CPG Styles Study: A Study of the Safety of the Contour Profile Gel Breast Implants (CPG Styles Study) Completed NCT01959880 Phase 3
3 Core Gel Study of the Safety and Effectiveness of Mentor Round Low Bleed Silicone Gel-filled Mammary Prostheses Completed NCT00753922 Phase 3
4 Mentor Siltex® Contour Profile Gel Mammary Prosthesis Clinical Trial Completed NCT00812097 Phase 3
5 Sexual Function in Men Receiving Dutasteride for Androgenetic Alopecia Completed NCT02014584 Phase 3 Dutasteride;Placebo
6 Prevention of the Progression of Coronary Calcification With Use of Spironolactone in Peritoneal Dialysis Patients Completed NCT03314493 Phase 3 Spironolactone 25Mg Tablet
7 Spectra Breast Implant Study Withdrawn NCT00981266 Phase 3
8 Testolactone for the Treatment of Girls With LHRH Resistant Precocious Puberty Completed NCT00001181 Phase 2 Testolactone
9 Effects of Letrozole on Precocious Puberty Due to McCune Albright Syndrome Completed NCT00006174 Phase 1 Letrozole
10 Postural Control in Breast Hypertrophy Completed NCT01519024
11 Physical Activity and Sexuality After Reduction Mammaplasty Completed NCT01297621 Not Applicable
12 Sexuality After Reduction Mammaplasty Completed NCT01020422 Not Applicable
13 Quality of Life Among Breast Reduction Patients Completed NCT00149370
14 Vertical Scar Versus Inferior Pedicle Reduction Mammoplasty Completed NCT00149344 Not Applicable
15 Randomized Controlled Trial of Subcuticular Skin Closure Versus Steri-strip S Closure Completed NCT00727025 Not Applicable
16 Cost-effectiveness of Reduction Mammaplasty Completed NCT00992368 Not Applicable
17 Dressing Wear Time After Reduction Mammaplasty Completed NCT01002391 Not Applicable
18 Ultrasound Guided Bilateral Erector Spinae Plane Block Versus Tumescent Anesthesia Recruiting NCT03558880 Not Applicable
19 UltraShape Device for Non-Invasive Fat Reduction in the Male Breast (Pseudogynecomastia) Recruiting NCT02711605 Not Applicable
20 White Light Scanning to Aid Body Contouring: A Pilot Project Recruiting NCT01093950

Search NIH Clinical Center for Hypertrophy of Breast

Genetic Tests for Hypertrophy of Breast

Anatomical Context for Hypertrophy of Breast

MalaCards organs/tissues related to Hypertrophy of Breast:

41
Breast, Skin

Publications for Hypertrophy of Breast

Articles related to Hypertrophy of Breast:

# Title Authors Year
1
Idiopathic galactorrhea with massive hypertrophy of breasts (a variant of Ahumada Del-Castillo syndrome). ( 4800169 )
1973

Variations for Hypertrophy of Breast

Expression for Hypertrophy of Breast

Search GEO for disease gene expression data for Hypertrophy of Breast.

Pathways for Hypertrophy of Breast

GO Terms for Hypertrophy of Breast

Cellular components related to Hypertrophy of Breast according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 trans-Golgi network GO:0005802 8.62 ARFGEF1 GCC2

Biological processes related to Hypertrophy of Breast according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ciliary basal body-plasma membrane docking GO:0097711 8.62 CNTRL SCLT1

Sources for Hypertrophy of Breast

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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