MCID: HYP049
MIFTS: 24

Hypertrophy of Tongue Papillae

Categories: Gastrointestinal diseases, Oral diseases, Smell/Taste diseases

Aliases & Classifications for Hypertrophy of Tongue Papillae

MalaCards integrated aliases for Hypertrophy of Tongue Papillae:

Name: Hypertrophy of Tongue Papillae 12 15 32
Tongue Papillary Hypertrophy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13333
ICD9CM 34 529.3
SNOMED-CT 67 6971002
ICD10 32 K14.3
UMLS 71 C0392494

Summaries for Hypertrophy of Tongue Papillae

MalaCards based summary : Hypertrophy of Tongue Papillae, also known as tongue papillary hypertrophy, is related to sulfamethoxazole allergy and abacavir allergy. An important gene associated with Hypertrophy of Tongue Papillae is SLC9A3 (Solute Carrier Family 9 Member A3), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. Affiliated tissues include tongue.

Related Diseases for Hypertrophy of Tongue Papillae

Diseases related to Hypertrophy of Tongue Papillae via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 sulfamethoxazole allergy 10.1 CYP2C9 CYP2C8
2 abacavir allergy 10.1 CYP2C9 CYP2B6
3 mixed epithelial stromal tumour 10.0 CYP3A4 CYP1A2
4 phenytoin toxicity 10.0 CYP2C9 CYP2C19
5 female stress incontinence 10.0 CYP2D6 CYP1A2
6 inhibited female orgasm 10.0 CYP3A4 CYP2C19
7 tardive dyskinesia 10.0 CYP2D6 CYP1A2
8 sulfonamide allergy 9.9 CYP2D6 CYP2C9
9 hepatocellular adenoma 9.9 CYP3A4 CYP1A2
10 osteonecrosis 9.9 CYP3A4 CYP2C8
11 serotonin syndrome 9.9 CYP3A4 CYP2D6
12 acute frontal sinusitis 9.9 PPIG CYP2B6
13 hepatitis d 9.9 CYP2D6 CYP2C9
14 hemorrhagic cystitis 9.9 PPIG CYP2B6
15 danubian endemic familial nephropathy 9.8 PPIG CYP1A2
16 sexual disorder 9.8 CYP3A4 CYP2D6
17 angiodysplasia of intestine 9.8 CYP3A4 CYP2C9 CYP1A2
18 gastroparesis 9.8 CYP3A4 CYP2D6
19 gastrojejunal ulcer 9.8 CYP3A4 CYP2C9 CYP1A2
20 esophageal candidiasis 9.8 CYP3A4 CYP2C9 CYP2C19
21 generalized anxiety disorder 9.7 CYP2D6 CYP1A2
22 retinitis pigmentosa 18 9.7 PPIG CYP3A4
23 multiple chemical sensitivity 9.7 CYP2D6 CYP2C9 CYP2C19
24 drug-induced hepatitis 9.7 CYP2D6 CYP2C9 CYP2C19
25 tobacco addiction 9.7 PPIG CYP2B6 CYP1A2
26 bilirubin metabolic disorder 9.6 PPIG CYP3A4
27 mucormycosis 9.6 PPIG CYP3A4 CYP2C19
28 mycobacterium tuberculosis 1 9.6 PPIG CYP3A4 CYP2B6
29 lennox-gastaut syndrome 9.6 PPIG CYP3A4 CYP2C19
30 conidiobolomycosis 9.5 PPIG CYP3A4 CYP2D6
31 acetaminophen metabolism 9.5 CYP3A4 CYP2D6 CYP2C19 CYP1A2
32 anxiety 9.5 CYP3A4 CYP2D6 CYP2C19 CYP1A2
33 migraine with or without aura 1 9.4 PPIG CYP3A4 CYP2D6
34 liver cirrhosis 9.4 CYP3A4 CYP2D6 CYP1A2
35 diarrhea 9.3 SLC9A3 PPIG CYP3A4 CYP2D6
36 neonatal abstinence syndrome 9.3 PPIG CYP3A4 CYP2D6 CYP2B6
37 heart conduction disease 9.3 PPIG CYP3A4 CYP2C9 CYP2C19
38 outlet dysfunction constipation 9.3 PPIG CYP3A4 CYP2D6 CYP2C19
39 clopidogrel resistance 9.1 PPIG CYP3A4 CYP2C9 CYP2C19 CYP1A2
40 major depressive disorder 9.0 CYP3A4 CYP2D6 CYP2C9 CYP2C19 CYP2B6 CYP1A2
41 heart disease 8.9 PPIG CYP3A4 CYP2D6 CYP2C9 CYP2C19
42 coumarin resistance 8.8 PPIG CYP3A4 CYP2D6 CYP2C9 CYP2C19 CYP1A2
43 hypertension, essential 8.6 SLC9A3 PPIG CYP3A4 CYP2D6 CYP2C9 CYP2C8
44 severe cutaneous adverse reaction 8.6 PPIG CYP3A4 CYP2D6 CYP2C9 CYP2C19 CYP2B6
45 disease of mental health 8.5 PPIG CYP3A4 CYP2D6 CYP2C9 CYP2C19 CYP2B6

Graphical network of the top 20 diseases related to Hypertrophy of Tongue Papillae:



Diseases related to Hypertrophy of Tongue Papillae

Symptoms & Phenotypes for Hypertrophy of Tongue Papillae

Drugs & Therapeutics for Hypertrophy of Tongue Papillae

Search Clinical Trials , NIH Clinical Center for Hypertrophy of Tongue Papillae

Genetic Tests for Hypertrophy of Tongue Papillae

Anatomical Context for Hypertrophy of Tongue Papillae

MalaCards organs/tissues related to Hypertrophy of Tongue Papillae:

40
Tongue

Publications for Hypertrophy of Tongue Papillae

Variations for Hypertrophy of Tongue Papillae

Expression for Hypertrophy of Tongue Papillae

Search GEO for disease gene expression data for Hypertrophy of Tongue Papillae.

Pathways for Hypertrophy of Tongue Papillae

Pathways related to Hypertrophy of Tongue Papillae according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
2
Show member pathways
13.12 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
3
Show member pathways
12.75 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
4 12.33 CYP3A4 CYP2D6 CYP1A2
5
Show member pathways
12.11 CYP2C9 CYP2C8 CYP2C19 CYP1A2
6 11.95 CYP2D6 CYP2C9 CYP2C8 CYP2C19
7
Show member pathways
11.94 CYP3A4 CYP2C9 CYP2C8 CYP2C19 CYP2B6 CYP1A2
8
Show member pathways
11.9 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
9
Show member pathways
11.77 CYP3A4 CYP2D6 CYP2B6 CYP1A2
10
Show member pathways
11.66 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP1A2
11
Show member pathways
11.59 CYP3A4 CYP2C9 CYP2C8 CYP2C19 CYP1A2
12
Show member pathways
11.57 CYP3A4 CYP2D6 CYP2C9 CYP2C8
13 11.54 CYP3A4 CYP2C9 CYP2C19 CYP2B6 CYP1A2
14
Show member pathways
11.5 CYP3A4 CYP1A2
15
Show member pathways
11.44 CYP3A4 CYP2C8
16 11.39 CYP3A4 CYP2C9 CYP2B6 CYP1A2
17
Show member pathways
11.38 CYP3A4 CYP2D6 CYP2C9 CYP1A2
18 11.35 CYP2D6 CYP2C19 CYP1A2
19 11.33 CYP3A4 CYP2C9 CYP2C19 CYP2B6
20
Show member pathways
11.31 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
21
Show member pathways
11.29 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
22
Show member pathways
11.25 CYP3A4 CYP2D6 CYP2C9 CYP2C19 CYP1A2
23
Show member pathways
11.19 CYP3A4 CYP1A2
24 11.19 CYP3A4 CYP2C9 CYP2C8 CYP1A2
25
Show member pathways
11.13 CYP3A4 CYP1A2
26
Show member pathways
11.12 CYP3A4 CYP2D6 CYP2C9 CYP2B6
27
Show member pathways
11.08 CYP2C9 CYP2C8
28
Show member pathways
11.01 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
29 11 CYP3A4 CYP1A2
30
Show member pathways
10.96 CYP3A4 CYP2D6 CYP1A2
31 10.94 CYP3A4 CYP2C9
32
Show member pathways
10.93 CYP2C9 CYP2B6
33 10.8 CYP3A4 CYP2C8
34 10.77 CYP2D6 CYP2B6
35 10.57 CYP2D6 CYP1A2
36 10.46 CYP2C9 CYP2C8

GO Terms for Hypertrophy of Tongue Papillae

Cellular components related to Hypertrophy of Tongue Papillae according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.8 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
2 endoplasmic reticulum membrane GO:0005789 9.7 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
3 intracellular membrane-bounded organelle GO:0043231 9.56 PPIG CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19
4 organelle membrane GO:0031090 9.17 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6

Biological processes related to Hypertrophy of Tongue Papillae according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 10.08 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
2 lipid metabolic process GO:0006629 10.04 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP1A2
3 fatty acid metabolic process GO:0006631 9.89 CYP3A4 CYP2D6 CYP2C19 CYP1A2
4 cholesterol metabolic process GO:0008203 9.88 CYP3A4 CYP2D6 CYP2C9 CYP1A2
5 estrogen metabolic process GO:0008210 9.88 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP1A2
6 steroid metabolic process GO:0008202 9.87 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
7 retinol metabolic process GO:0042572 9.86 CYP3A4 CYP2D6 CYP2C8 CYP1A2
8 arachidonic acid metabolic process GO:0019369 9.85 CYP2D6 CYP2C9 CYP2C8 CYP1A2
9 long-chain fatty acid biosynthetic process GO:0042759 9.85 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP1A2
10 omega-hydroxylase P450 pathway GO:0097267 9.83 CYP2C9 CYP2C8 CYP2C19 CYP1A2
11 organic acid metabolic process GO:0006082 9.83 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
12 heterocycle metabolic process GO:0046483 9.81 CYP3A4 CYP2D6 CYP2C19 CYP1A2
13 drug catabolic process GO:0042737 9.8 CYP3A4 CYP2D6 CYP2C9 CYP1A2
14 epoxygenase P450 pathway GO:0019373 9.8 CYP2C9 CYP2C8 CYP2C19 CYP2B6 CYP1A2
15 xenobiotic metabolic process GO:0006805 9.8 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
16 oxidative demethylation GO:0070989 9.77 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP1A2
17 retinoic acid metabolic process GO:0042573 9.63 CYP3A4 CYP2C8
18 lipid hydroxylation GO:0002933 9.62 CYP3A4 CYP2C8
19 icosanoid biosynthetic process GO:0046456 9.62 CYP2C9 CYP2C8
20 steroid catabolic process GO:0006706 9.61 CYP3A4 CYP1A2
21 monocarboxylic acid metabolic process GO:0032787 9.61 CYP2C9 CYP1A2
22 alkaloid catabolic process GO:0009822 9.6 CYP3A4 CYP2D6
23 alkaloid metabolic process GO:0009820 9.58 CYP2D6 CYP1A2
24 monoterpenoid metabolic process GO:0016098 9.55 CYP3A4 CYP2D6 CYP2C9 CYP2C19 CYP1A2
25 exogenous drug catabolic process GO:0042738 9.5 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
26 drug metabolic process GO:0017144 9.17 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6

Molecular functions related to Hypertrophy of Tongue Papillae according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 10.11 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
2 oxidoreductase activity GO:0016491 10.02 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
3 heme binding GO:0020037 9.91 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
4 iron ion binding GO:0005506 9.87 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
5 aromatase activity GO:0070330 9.83 CYP3A4 CYP2C9 CYP2C8 CYP2C19 CYP1A2
6 enzyme binding GO:0019899 9.76 CYP3A4 CYP2C19 CYP1A2
7 arachidonic acid epoxygenase activity GO:0008392 9.76 CYP2C9 CYP2C8 CYP2C19 CYP2B6
8 steroid hydroxylase activity GO:0008395 9.73 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
9 caffeine oxidase activity GO:0034875 9.71 CYP3A4 CYP2C9 CYP2C8 CYP1A2
10 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.7 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
11 estrogen 16-alpha-hydroxylase activity GO:0101020 9.69 CYP3A4 CYP2C8 CYP1A2
12 estrogen 2-hydroxylase activity GO:0101021 9.67 CYP3A4 CYP2B6 CYP1A2
13 oxygen binding GO:0019825 9.58 CYP3A4 CYP2C19
14 retinoic acid 4-hydroxylase activity GO:0008401 9.56 CYP3A4 CYP2C8
15 (R)-limonene 6-monooxygenase activity GO:0052741 9.55 CYP2C9 CYP2C19
16 (S)-limonene 7-monooxygenase activity GO:0018676 9.54 CYP2C9 CYP2C19
17 (S)-limonene 6-monooxygenase activity GO:0018675 9.52 CYP2C9 CYP2C19
18 monooxygenase activity GO:0004497 9.5 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
19 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.17 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6

Sources for Hypertrophy of Tongue Papillae

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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