Hypertrophy of Tongue Papillae disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HYP049 MIFTS: 24	Hypertrophy of Tongue Papillae Categories: Gastrointestinal diseases, Oral diseases
Genes Tissues Related diseases Pathways Expand all tables

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Aliases & Classifications for Hypertrophy of Tongue Papillae

MalaCards integrated aliases for Hypertrophy of Tongue Papillae:

Name: Hypertrophy of Tongue Papillae ¹² ¹⁵ ³²

Tongue Papillary Hypertrophy ¹²

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases Oral diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the digestive system

Diseases of oral cavity, salivary glands and jaws

Diseases of tongue

Hypertrophy of tongue papillae

External Ids:

Disease Ontology ¹² DOID:13333

ICD9CM ³⁴ 529.3

SNOMED-CT ⁶⁷ 6971002

ICD10 ³² K14.3

UMLS ⁷¹ C0392494

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Summaries for Hypertrophy of Tongue Papillae

MalaCards based summary : Hypertrophy of Tongue Papillae, also known as tongue papillary hypertrophy, is related to sulfamethoxazole allergy and liver benign neoplasm. An important gene associated with Hypertrophy of Tongue Papillae is SLC9A3 (Solute Carrier Family 9 Member A3), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. Affiliated tissues include tongue, salivary gland and liver.

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Related Diseases for Hypertrophy of Tongue Papillae

Diseases related to Hypertrophy of Tongue Papillae via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)

#	Related Disease	Score	Top Affiliating Genes
1	sulfamethoxazole allergy	10.1	CYP2C9 CYP2C8
2	liver benign neoplasm	10.1	CYP2B6 CYP1A2
3	abacavir allergy	10.1	CYP2C9 CYP2B6
4	mixed epithelial stromal tumour	10.0	CYP3A4 CYP1A2
5	phenytoin toxicity	10.0	CYP2C9 CYP2C19
6	tardive dyskinesia	10.0	CYP2D6 CYP1A2
7	antidepressant or antipsychotic toxicity or dose selection	10.0	CYP2D6 CYP2C19
8	amelogenesis imperfecta, type ib	9.9	CYP2D6 CYP1A2
9	sulfonamide allergy	9.9	CYP2D6 CYP2C9
10	functional gastric disease	9.9	CYP3A4 CYP2C19
11	serotonin syndrome	9.8	CYP3A4 CYP2D6
12	hepatocellular adenoma	9.8	CYP3A4 CYP1A2
13	pulmonary artery disease	9.8	CYP3A4 CYP2C9
14	hepatitis d	9.8	CYP2D6 CYP2C9
15	hemorrhagic cystitis	9.8	PPIG CYP2B6
16	osteonecrosis	9.8	CYP3A4 CYP2C8
17	danubian endemic familial nephropathy	9.7	PPIG CYP1A2
18	sexual disorder	9.7	CYP3A4 CYP2D6
19	macular degeneration, age-related, 2	9.7	PPIG CYP3A4
20	angiodysplasia of intestine	9.7	CYP3A4 CYP2C9 CYP1A2
21	nasopharyngitis	9.7	PPIG CYP3A4
22	esophageal candidiasis	9.7	CYP3A4 CYP2C9 CYP2C19
23	gastroparesis	9.6	CYP3A4 CYP2D6
24	multiple chemical sensitivity	9.6	CYP2D6 CYP2C9 CYP2C19
25	drug-induced hepatitis	9.6	CYP2D6 CYP2C9 CYP2C19
26	tobacco addiction	9.5	PPIG CYP2B6 CYP1A2
27	generalized anxiety disorder	9.5	CYP2D6 CYP1A2
28	mucormycosis	9.4	PPIG CYP3A4 CYP2C19
29	mycobacterium tuberculosis 1	9.4	PPIG CYP3A4 CYP2B6
30	conidiobolomycosis	9.3	PPIG CYP3A4 CYP2D6
31	acetaminophen metabolism	9.3	CYP3A4 CYP2D6 CYP2C19 CYP1A2
32	anxiety	9.2	CYP3A4 CYP2D6 CYP2C19 CYP1A2
33	diarrhea	9.0	SLC9A3 PPIG CYP3A4 CYP2D6
34	major depressive disorder	9.0	CYP2D6 CYP2C9 CYP2C19 CYP2B6 CYP1A2
35	clopidogrel resistance	8.7	PPIG CYP3A4 CYP2C9 CYP2C19 CYP1A2
36	hypertension, essential	8.1	SLC9A3 PPIG CYP3A4 CYP2D6 CYP2C9 CYP2C8
37	severe cutaneous adverse reaction	8.0	PPIG CYP3A4 CYP2D6 CYP2C9 CYP2C19 CYP2B6

Graphical network of the top 20 diseases related to Hypertrophy of Tongue Papillae:

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Symptoms & Phenotypes for Hypertrophy of Tongue Papillae

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Drugs & Therapeutics for Hypertrophy of Tongue Papillae

Search Clinical Trials , NIH Clinical Center for Hypertrophy of Tongue Papillae

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Genetic Tests for Hypertrophy of Tongue Papillae

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Anatomical Context for Hypertrophy of Tongue Papillae

MalaCards organs/tissues related to Hypertrophy of Tongue Papillae:

⁴⁰

Tongue, Salivary Gland, Liver

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Publications for Hypertrophy of Tongue Papillae

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Genes for Hypertrophy of Tongue Papillae

Genes related to Hypertrophy of Tongue Papillae (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SLC9A3	Solute Carrier Family 9 Member A3	Protein Coding	5.05	DISEASES inferred ¹⁵
2	CYP2C8	Cytochrome P450 Family 2 Subfamily C Member 8	Protein Coding	4.87	DISEASES inferred ¹⁵
3	CYP2B6	Cytochrome P450 Family 2 Subfamily B Member 6	Protein Coding	4.48	DISEASES inferred ¹⁵
4	CYP1A2	Cytochrome P450 Family 1 Subfamily A Member 2	Protein Coding	4.4	DISEASES inferred ¹⁵
5	CYP2C19	Cytochrome P450 Family 2 Subfamily C Member 19	Protein Coding	4.4	DISEASES inferred ¹⁵
6	CYP2C9	Cytochrome P450 Family 2 Subfamily C Member 9	Protein Coding	4.37	DISEASES inferred ¹⁵
7	CYP2D6	Cytochrome P450 Family 2 Subfamily D Member 6	Protein Coding	4.26	DISEASES inferred ¹⁵
8	PPIG	Peptidylprolyl Isomerase G	Protein Coding	4	DISEASES inferred ¹⁵
9	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	3.9	DISEASES inferred ¹⁵

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Variations for Hypertrophy of Tongue Papillae

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Expression for Hypertrophy of Tongue Papillae

Search GEO for disease gene expression data for Hypertrophy of Tongue Papillae.

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Pathways for Hypertrophy of Tongue Papillae

Pathways related to Hypertrophy of Tongue Papillae according to GeneCards Suite gene sharing:

(show all 36)

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism ⁶⁵ Show member pathways Metabolic pathways ³⁶ Metabolism of lipids and lipoproteins ⁶⁵	13.85	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
2	Cytochrome P450 - arranged by substrate type ⁶⁵ Show member pathways Amine Oxidase reactions ⁶⁵ Aryl hydrocarbon receptor signalling ⁶⁵ Benzo(a)pyrene metabolism ¹ Biological oxidations ⁶⁵ bupropion degradation ¹ CYP2E1 reactions ⁶⁵ Cytosolic sulfonation of small molecules ⁶⁵ Eicosanoids ⁶⁵ Endogenous sterols ⁶⁵ Estradiol metabolism ²² Ethanol oxidation ⁶⁵ Fatty Acid Omega Oxidation ¹ Fatty acids ⁶⁵ Lidocaine Pathway, Pharmacokinetics ⁶⁰ Metapathway biotransformation ¹ Methylation ⁶⁵ Methylphenidate Pathway, Pharmacokinetics ⁶⁰ Miscellaneous substrates ⁶⁵ Oxidation by Cytochrome P450 ¹ Phase 1 - Functionalization of compounds ⁶⁵ Phase II conjugation ⁶⁵ Sterols are 12-hydroxylated by CYP8B1 ⁶⁵ Transport and synthesis of PAPS ⁶⁵ Vitamin D2 (ergocalciferol) metabolism ²² vitamin D3 biosynthesis ¹ Vitamins ⁶⁵ Xenobiotics ⁶⁵	13.1	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
3	Drug metabolism - cytochrome P450 ³⁶ Show member pathways Aflatoxin B1 metabolism ¹ Artemisinin and Derivatives Pathway, Pharmacokinetics ⁶⁰ Arylamine metabolism ¹ Benzo[a]pyrene metabolism ²² Benzodiazepine Pathway, Pharmacokinetics ⁶⁰ Celecoxib Pathway, Pharmacokinetics ⁶⁰ Chemical carcinogenesis ³⁶ Drug metabolism - other enzymes ³⁶ Fluoxetine Pathway, Pharmacokinetics ⁶⁰ Fluvoxamine Pathway, Pharmacokinetics ⁶⁰ Haloperidol Pathway, Pharmacokinetics ⁶⁰ Ifosfamide Pathway, Pharmacokinetics ⁶⁰ Metabolism of xenobiotics by cytochrome P450 ³⁶ Naproxen Pathway, Pharmacokinetics ⁶⁰ Nicotine Metabolism ¹ Nicotine Pathway, Pharmacokinetics ⁶⁰ Retinol metabolism ²² Retinol metabolism ³⁶ Sertraline Pathway, Pharmacokinetics ⁶⁰ Voriconazole Pathway, Pharmacokinetics ⁶⁰	12.75	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
4	Glucose / Energy Metabolism ⁴	12.32	CYP3A4 CYP2D6 CYP1A2
5	Arachidonic acid metabolism ⁶⁵ Show member pathways alpha-tocopherol degradation ¹ Amodiaquine Pathway, Pharmacokinetics ⁶⁰ anandamide degradation ¹ C20 prostanoid biosynthesis ¹ COX reactions ⁶⁵ leukotriene biosynthesis ¹ Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) ⁶⁵ Synthesis of 12-eicosatetraenoic acid derivatives ⁶⁵ Synthesis of 15-eicosatetraenoic acid derivatives ⁶⁵ Synthesis of 5-eicosatetraenoic acids ⁶⁵ Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) ⁶⁵ Synthesis of Leukotrienes (LT) and Eoxins (EX) ⁶⁵ Synthesis of Lipoxins (LX) ⁶⁵ Synthesis of Prostaglandins (PG) and Thromboxanes (TX) ⁶⁵	12.1	CYP2C9 CYP2C8 CYP2C19 CYP1A2
6	Serotonergic synapse ³⁶	11.95	CYP2D6 CYP2C9 CYP2C8 CYP2C19
7	Linoleic acid metabolism ³⁶ Show member pathways alpha-Linolenic acid metabolism ³⁶ Arachidonic acid metabolism ³⁶	11.95	CYP3A4 CYP2C9 CYP2C8 CYP2C19 CYP2B6 CYP1A2
8	Statin Pathway - Generalized, Pharmacokinetics ⁶⁰ Show member pathways Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics ⁶⁰ Anti-diabetic Drug Repaglinide Pathway, Pharmacokinetics ⁶⁰ Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics ⁶⁰ Clobazam Pathway, Pharmacokinetics ⁶⁰ Diclofenac Metabolic Pathway ¹ Diclofenac Pathway, Pharmacokinetics ⁶⁰ Fluvastatin Pathway, Pharmacokinetics ⁶⁰ Ibuprofen Pathway, Pharmacokinetics ⁶⁰ Pravastatin Pathway, Pharmacokinetics ⁶⁰ Rosiglitazone Pathway, Pharmacokinetics ⁶⁰ Rosuvastatin Pathway, Pharmacokinetics ⁶⁰	11.9	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
9	Imipramine/Desipramine Pathway, Pharmacokinetics ⁶⁰ Show member pathways Amitriptyline and Nortriptyline Pathway, Pharmacokinetics ⁶⁰ Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 ⁶⁵ Candesartan Pathway, Pharmacokinetics ⁶⁰ Citalopram Pathway, Pharmacokinetics ⁶⁰ Clomipramine Pathway, Pharmacokinetics ⁶⁰ Clozapine Pathway, Pharmacokinetics ⁶⁰ Doxepin Pathway, Pharmacokinetics ⁶⁰ Lidocaine metabolism ¹ Metoprolol Pathway, Pharmacokinetics ⁶⁰ Nevirapine Pathway, Pharmacokinetics ⁶⁰ Olanzapine Pathway, Pharmacokinetics ⁶⁰ Paroxetine Pathway, Pharmacokinetics ⁶⁰ Proton Pump Inhibitor Pathway, Pharmacokinetics ⁶⁰ Venlafaxine Pathway, Pharmacokinetics ⁶⁰ Verapamil Pathway, Pharmacokinetics ⁶⁰ Warfarin Pathway, Pharmacokinetics ⁶⁰	11.81	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
10	Acetaminophen Pathway (therapeutic doses), Pharmacokinetics ⁶⁰ Show member pathways 2-Naphthylamine and 2-Nitronaphtalene metabolism ²² Acetaminophen metabolism ²² Acetaminophen Pathway (toxic doses), Pharmacokinetics ⁶⁰	11.77	CYP3A4 CYP2D6 CYP2B6 CYP1A2
11	Androstenedione and testosterone biosynthesis and metabolism p.1 ²² Show member pathways Estrogen biosynthesis ²² Estrone metabolism ²² Steroid Biosynthesis ¹	11.59	CYP3A4 CYP2C9 CYP2C8 CYP2C19 CYP1A2
12	Carvedilol Pathway, Pharmacokinetics ⁶⁰ Show member pathways Clopidogrel Pathway, Pharmacokinetics ⁶⁰ Codeine and Morphine Metabolism ¹ Codeine and Morphine Pathway, Pharmacokinetics ⁶⁰ Ivacaftor pathway, pharmacokinetics/pharmacodynamics ⁶⁰ Losartan Pathway, Pharmacokinetics ⁶⁰ Macrolide Antibiotic Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Oxycodone Pathway, Pharmacokinetics ⁶⁰ Tacrolimus/Cyclosporine Pathway, Pharmacokinetics ⁶⁰ Tramadol Pharmacokinetics ⁶⁰	11.57	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
13	Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Show member pathways Bosutinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Imatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Nilotinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Taxane Pathway, Pharmacokinetics ⁶⁰	11.56	CYP3A4 CYP2D6 CYP2C9 CYP2C8
14	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics ⁶⁰	11.54	CYP3A4 CYP2C9 CYP2C19 CYP2B6 CYP1A2
15	Bile secretion ³⁶	11.53	SLC9A3 CYP3A4
16	Steroid hormone biosynthesis ³⁶ Show member pathways allopregnanolone biosynthesis ¹	11.49	CYP3A4 CYP1A2
17	Irinotecan Pathway, Pharmacokinetics ⁶⁰ Show member pathways Irinotecan Pathway ¹ Irinotecan Pathway, Pharmacodynamics ⁶⁰ Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	11.43	CYP3A4 CYP2C8
18	Nuclear Receptors in Lipid Metabolism and Toxicity ¹	11.38	CYP3A4 CYP2C9 CYP2B6 CYP1A2
19	Erlotinib Pathway, Pharmacokinetics ⁶⁰ Show member pathways Atazanavir Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Dasatinib Pathway, Pharmacokinetics ⁶⁰ Gefitinib Pathway, Pharmacokinetics ⁶⁰	11.37	CYP3A4 CYP2D6 CYP2C9 CYP1A2
20	Melatonin metabolism and effects ¹	11.34	CYP2D6 CYP2C19 CYP1A2
21	Constitutive Androstane Receptor Pathway ¹	11.32	CYP3A4 CYP2C9 CYP2C19 CYP2B6
22	Pazopanib Pathway, Pharmacokinetics ⁶⁰ Show member pathways Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	11.25	CYP3A4 CYP2D6 CYP2C9 CYP2C19 CYP1A2
23	Estrogen metabolism ¹ Show member pathways Estrogen Metabolism Pathway ⁶⁰	11.18	CYP3A4 CYP1A2
24	Naphthalene metabolism ²²	11.18	CYP3A4 CYP2C9 CYP2C8 CYP1A2
25	Tamoxifen metabolism ¹ Show member pathways Tamoxifen Pathway, Pharmacokinetics ⁶⁰	11.09	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
26	HETE and HPETE biosynthesis and metabolism ²² Show member pathways lipoxin biosynthesis ¹ resolvin D biosynthesis ¹ Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ⁶⁵	11.08	CYP2C9 CYP2C8
27	Caffeine Pathway, Pharmacokinetics ⁶⁰ Show member pathways Acetylation ⁶⁵ Caffeine and Theobromine metabolism ¹ Caffeine metabolism ³⁶ Colchicine Metabolic Pathway ¹ Felbamate Metabolism ¹ Gut-Liver Indole Metabolism ¹ Theophylline Pathway, Pharmacokinetics ⁶⁰	11.04	CYP3A4 CYP1A2
28	Aflatoxin activation and detoxification ⁶⁵	11	CYP3A4 CYP1A2
29	Phenytoin Pathway, Pharmacokinetics ⁶⁰ Show member pathways Atomoxetine Pathway, Pharmacokinetics ⁶⁰ Carbamazepine Pathway, Pharmacokinetics ⁶⁰ Cyclophosphamide Pathway, Pharmacokinetics ⁶⁰ Efavirenz Pathway, Pharmacokinetics ⁶⁰ Sorafenib Pharmacokinetics ⁶⁰	10.97	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
30	Tropisetron Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Show member pathways Ondansetron Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.96	CYP3A4 CYP2D6 CYP1A2
31	Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.93	CYP3A4 CYP2C9
32	Valproic acid pathway ¹ Show member pathways Valproic Acid Pathway, Pharmacokinetics ⁶⁰	10.93	CYP2C9 CYP2B6
33	Sirolimus Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.8	CYP3A4 CYP2C8
34	Bupropion Pathway, Pharmacokinetics ⁶⁰	10.76	CYP2D6 CYP2B6
35	Propranolol Pathway, Pharmacokinetics ⁶⁰	10.57	CYP2D6 CYP1A2
36	Arachidonate Epoxygenase / Epoxide Hydrolase ¹	10.45	CYP2C9 CYP2C8

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GO Terms for Hypertrophy of Tongue Papillae

Cellular components related to Hypertrophy of Tongue Papillae according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endoplasmic reticulum	GO:0005783	9.8	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
2	endoplasmic reticulum membrane	GO:0005789	9.7	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
3	intracellular membrane-bounded organelle	GO:0043231	9.5	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
4	organelle membrane	GO:0031090	9.17	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6

Biological processes related to Hypertrophy of Tongue Papillae according to GeneCards Suite gene sharing:

(show all 26)

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidation-reduction process	GO:0055114	10.09	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
2	lipid metabolic process	GO:0006629	10.04	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP1A2
3	fatty acid metabolic process	GO:0006631	9.89	CYP3A4 CYP2D6 CYP2C19 CYP1A2
4	cholesterol metabolic process	GO:0008203	9.88	CYP3A4 CYP2D6 CYP2C9 CYP1A2
5	long-chain fatty acid biosynthetic process	GO:0042759	9.88	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP1A2
6	steroid metabolic process	GO:0008202	9.87	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
7	retinol metabolic process	GO:0042572	9.86	CYP3A4 CYP2D6 CYP2C8 CYP1A2
8	organic acid metabolic process	GO:0006082	9.85	CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
9	arachidonic acid metabolic process	GO:0019369	9.84	CYP2D6 CYP2C9 CYP2C8 CYP1A2
10	omega-hydroxylase P450 pathway	GO:0097267	9.83	CYP2C9 CYP2C8 CYP2C19 CYP1A2
11	epoxygenase P450 pathway	GO:0019373	9.83	CYP2C9 CYP2C8 CYP2C19 CYP2B6 CYP1A2
12	heterocycle metabolic process	GO:0046483	9.81	CYP3A4 CYP2D6 CYP2C19 CYP1A2
13	drug catabolic process	GO:0042737	9.8	CYP3A4 CYP2D6 CYP2C9 CYP1A2
14	estrogen metabolic process	GO:0008210	9.8	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP1A2
15	xenobiotic metabolic process	GO:0006805	9.8	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
16	oxidative demethylation	GO:0070989	9.77	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP1A2
17	retinoic acid metabolic process	GO:0042573	9.63	CYP3A4 CYP2C8
18	lipid hydroxylation	GO:0002933	9.62	CYP3A4 CYP2C8
19	icosanoid biosynthetic process	GO:0046456	9.62	CYP2C9 CYP2C8
20	steroid catabolic process	GO:0006706	9.61	CYP3A4 CYP1A2
21	monocarboxylic acid metabolic process	GO:0032787	9.61	CYP2C9 CYP1A2
22	alkaloid catabolic process	GO:0009822	9.6	CYP3A4 CYP2D6
23	alkaloid metabolic process	GO:0009820	9.58	CYP2D6 CYP1A2
24	monoterpenoid metabolic process	GO:0016098	9.55	CYP3A4 CYP2D6 CYP2C9 CYP2C19 CYP1A2
25	exogenous drug catabolic process	GO:0042738	9.5	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
26	drug metabolic process	GO:0017144	9.17	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6

Molecular functions related to Hypertrophy of Tongue Papillae according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	metal ion binding	GO:0046872	10.08	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
2	oxidoreductase activity	GO:0016491	10.02	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
3	heme binding	GO:0020037	9.91	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
4	iron ion binding	GO:0005506	9.87	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
5	aromatase activity	GO:0070330	9.83	CYP3A4 CYP2C9 CYP2C8 CYP2C19 CYP1A2
6	arachidonic acid epoxygenase activity	GO:0008392	9.76	CYP2C9 CYP2C8 CYP2C19 CYP2B6
7	enzyme binding	GO:0019899	9.73	CYP3A4 CYP2C19 CYP1A2
8	steroid hydroxylase activity	GO:0008395	9.73	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
9	caffeine oxidase activity	GO:0034875	9.71	CYP3A4 CYP2C9 CYP2C8 CYP1A2
10	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0016705	9.7	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
11	estrogen 16-alpha-hydroxylase activity	GO:0101020	9.67	CYP3A4 CYP2C8 CYP1A2
12	drug binding	GO:0008144	9.57	CYP2D6 CYP2C9
13	oxygen binding	GO:0019825	9.55	CYP3A4 CYP2C19
14	retinoic acid 4-hydroxylase activity	GO:0008401	9.52	CYP3A4 CYP2C8
15	estrogen 2-hydroxylase activity	GO:0101021	9.51	CYP3A4 CYP1A2
16	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	GO:0016712	9.5	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
17	monooxygenase activity	GO:0004497	9.17	CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6

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