MCID: HYP049
MIFTS: 24

Hypertrophy of Tongue Papillae

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Hypertrophy of Tongue Papillae

MalaCards integrated aliases for Hypertrophy of Tongue Papillae:

Name: Hypertrophy of Tongue Papillae 12 15 32
Tongue Papillary Hypertrophy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13333
ICD9CM 34 529.3
SNOMED-CT 67 6971002
ICD10 32 K14.3
UMLS 71 C0392494

Summaries for Hypertrophy of Tongue Papillae

MalaCards based summary : Hypertrophy of Tongue Papillae, also known as tongue papillary hypertrophy, is related to sulfamethoxazole allergy and liver benign neoplasm. An important gene associated with Hypertrophy of Tongue Papillae is SLC9A3 (Solute Carrier Family 9 Member A3), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. Affiliated tissues include tongue and salivary gland.

Related Diseases for Hypertrophy of Tongue Papillae

Diseases related to Hypertrophy of Tongue Papillae via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 sulfamethoxazole allergy 10.1 CYP2C9 CYP2C8
2 liver benign neoplasm 10.1 CYP2B6 CYP1A2
3 abacavir allergy 10.1 CYP2C9 CYP2B6
4 mixed epithelial stromal tumour 10.1 CYP3A4 CYP1A2
5 phenytoin toxicity 10.0 CYP2C9 CYP2C19
6 tardive dyskinesia 10.0 CYP2D6 CYP1A2
7 antidepressant or antipsychotic toxicity or dose selection 10.0 CYP2D6 CYP2C19
8 amelogenesis imperfecta, type ib 9.9 CYP2D6 CYP1A2
9 functional gastric disease 9.9 CYP3A4 CYP2C19
10 sulfonamide allergy 9.9 CYP2D6 CYP2C9
11 hepatocellular adenoma 9.9 CYP3A4 CYP1A2
12 serotonin syndrome 9.8 CYP3A4 CYP2D6
13 pulmonary artery disease 9.8 CYP3A4 CYP2C9
14 hepatitis d 9.8 CYP2D6 CYP2C9
15 hemorrhagic cystitis 9.8 PPIG CYP2B6
16 osteonecrosis 9.8 CYP3A4 CYP2C8
17 sexual disorder 9.7 CYP3A4 CYP2D6
18 danubian endemic familial nephropathy 9.7 PPIG CYP1A2
19 macular degeneration, age-related, 2 9.7 PPIG CYP3A4
20 angiodysplasia of intestine 9.7 CYP3A4 CYP2C9 CYP1A2
21 nasopharyngitis 9.7 PPIG CYP3A4
22 gastroparesis 9.7 CYP3A4 CYP2D6
23 esophageal candidiasis 9.7 CYP3A4 CYP2C9 CYP2C19
24 multiple chemical sensitivity 9.6 CYP2D6 CYP2C9 CYP2C19
25 drug-induced hepatitis 9.6 CYP2D6 CYP2C9 CYP2C19
26 tobacco addiction 9.5 PPIG CYP2B6 CYP1A2
27 generalized anxiety disorder 9.5 CYP2D6 CYP1A2
28 mucormycosis 9.4 PPIG CYP3A4 CYP2C19
29 mycobacterium tuberculosis 1 9.4 PPIG CYP3A4 CYP2B6
30 liver cirrhosis 9.3 CYP3A4 CYP2D6 CYP1A2
31 conidiobolomycosis 9.3 PPIG CYP3A4 CYP2D6
32 acetaminophen metabolism 9.3 CYP3A4 CYP2D6 CYP2C19 CYP1A2
33 anxiety 9.2 CYP3A4 CYP2D6 CYP2C19 CYP1A2
34 diarrhea 9.0 SLC9A3 PPIG CYP3A4 CYP2D6
35 major depressive disorder 9.0 CYP2D6 CYP2C9 CYP2C19 CYP2B6 CYP1A2
36 clopidogrel resistance 8.7 PPIG CYP3A4 CYP2C9 CYP2C19 CYP1A2
37 hypertension, essential 8.1 SLC9A3 PPIG CYP3A4 CYP2D6 CYP2C9 CYP2C8
38 severe cutaneous adverse reaction 8.0 PPIG CYP3A4 CYP2D6 CYP2C9 CYP2C19 CYP2B6

Graphical network of the top 20 diseases related to Hypertrophy of Tongue Papillae:



Diseases related to Hypertrophy of Tongue Papillae

Symptoms & Phenotypes for Hypertrophy of Tongue Papillae

Drugs & Therapeutics for Hypertrophy of Tongue Papillae

Search Clinical Trials , NIH Clinical Center for Hypertrophy of Tongue Papillae

Genetic Tests for Hypertrophy of Tongue Papillae

Anatomical Context for Hypertrophy of Tongue Papillae

MalaCards organs/tissues related to Hypertrophy of Tongue Papillae:

40
Tongue, Salivary Gland

Publications for Hypertrophy of Tongue Papillae

Variations for Hypertrophy of Tongue Papillae

Expression for Hypertrophy of Tongue Papillae

Search GEO for disease gene expression data for Hypertrophy of Tongue Papillae.

Pathways for Hypertrophy of Tongue Papillae

Pathways related to Hypertrophy of Tongue Papillae according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
2
Show member pathways
13.1 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
3
Show member pathways
12.75 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
4 12.32 CYP3A4 CYP2D6 CYP1A2
5
Show member pathways
12.1 CYP2C9 CYP2C8 CYP2C19 CYP1A2
6 11.95 CYP2D6 CYP2C9 CYP2C8 CYP2C19
7
Show member pathways
11.95 CYP3A4 CYP2C9 CYP2C8 CYP2C19 CYP2B6 CYP1A2
8
Show member pathways
11.9 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
9
Show member pathways
11.81 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
10
Show member pathways
11.77 CYP3A4 CYP2D6 CYP2B6 CYP1A2
11
Show member pathways
11.59 CYP3A4 CYP2C9 CYP2C8 CYP2C19 CYP1A2
12
Show member pathways
11.57 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
13
Show member pathways
11.56 CYP3A4 CYP2D6 CYP2C9 CYP2C8
14 11.54 CYP3A4 CYP2C9 CYP2C19 CYP2B6 CYP1A2
15 11.53 SLC9A3 CYP3A4
16
Show member pathways
11.49 CYP3A4 CYP1A2
17
Show member pathways
11.43 CYP3A4 CYP2C8
18 11.38 CYP3A4 CYP2C9 CYP2B6 CYP1A2
19
Show member pathways
11.37 CYP3A4 CYP2D6 CYP2C9 CYP1A2
20 11.34 CYP2D6 CYP2C19 CYP1A2
21 11.32 CYP3A4 CYP2C9 CYP2C19 CYP2B6
22
Show member pathways
11.25 CYP3A4 CYP2D6 CYP2C9 CYP2C19 CYP1A2
23
Show member pathways
11.18 CYP3A4 CYP1A2
24 11.18 CYP3A4 CYP2C9 CYP2C8 CYP1A2
25
Show member pathways
11.09 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
26
Show member pathways
11.08 CYP2C9 CYP2C8
27
Show member pathways
11.04 CYP3A4 CYP1A2
28 11 CYP3A4 CYP1A2
29
Show member pathways
10.97 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
30
Show member pathways
10.96 CYP3A4 CYP2D6 CYP1A2
31 10.93 CYP3A4 CYP2C9
32
Show member pathways
10.93 CYP2C9 CYP2B6
33 10.8 CYP3A4 CYP2C8
34 10.76 CYP2D6 CYP2B6
35 10.57 CYP2D6 CYP1A2
36 10.45 CYP2C9 CYP2C8

GO Terms for Hypertrophy of Tongue Papillae

Cellular components related to Hypertrophy of Tongue Papillae according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.8 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
2 endoplasmic reticulum membrane GO:0005789 9.7 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
3 intracellular membrane-bounded organelle GO:0043231 9.5 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
4 organelle membrane GO:0031090 9.17 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6

Biological processes related to Hypertrophy of Tongue Papillae according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 10.09 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
2 lipid metabolic process GO:0006629 10.04 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP1A2
3 fatty acid metabolic process GO:0006631 9.89 CYP2C19 CYP2D6 CYP3A4 CYP1A2
4 cholesterol metabolic process GO:0008203 9.88 CYP3A4 CYP2D6 CYP2C9 CYP1A2
5 long-chain fatty acid biosynthetic process GO:0042759 9.88 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP1A2
6 steroid metabolic process GO:0008202 9.87 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
7 retinol metabolic process GO:0042572 9.86 CYP3A4 CYP2D6 CYP2C8 CYP1A2
8 organic acid metabolic process GO:0006082 9.85 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
9 arachidonic acid metabolic process GO:0019369 9.84 CYP2D6 CYP2C9 CYP2C8 CYP1A2
10 omega-hydroxylase P450 pathway GO:0097267 9.83 CYP2C9 CYP2C8 CYP2C19 CYP1A2
11 epoxygenase P450 pathway GO:0019373 9.83 CYP2C9 CYP2C8 CYP2C19 CYP2B6 CYP1A2
12 heterocycle metabolic process GO:0046483 9.81 CYP3A4 CYP2D6 CYP2C19 CYP1A2
13 drug catabolic process GO:0042737 9.8 CYP3A4 CYP2D6 CYP2C9 CYP1A2
14 estrogen metabolic process GO:0008210 9.8 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP1A2
15 xenobiotic metabolic process GO:0006805 9.8 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
16 oxidative demethylation GO:0070989 9.77 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP1A2
17 retinoic acid metabolic process GO:0042573 9.63 CYP2C8 CYP3A4
18 lipid hydroxylation GO:0002933 9.62 CYP2C8 CYP3A4
19 steroid catabolic process GO:0006706 9.62 CYP1A2 CYP3A4
20 icosanoid biosynthetic process GO:0046456 9.61 CYP2C8 CYP2C9
21 alkaloid catabolic process GO:0009822 9.61 CYP2D6 CYP3A4
22 monocarboxylic acid metabolic process GO:0032787 9.6 CYP1A2 CYP2C9
23 alkaloid metabolic process GO:0009820 9.58 CYP2D6 CYP1A2
24 monoterpenoid metabolic process GO:0016098 9.55 CYP3A4 CYP2D6 CYP2C9 CYP2C19 CYP1A2
25 exogenous drug catabolic process GO:0042738 9.5 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
26 drug metabolic process GO:0017144 9.17 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6

Molecular functions related to Hypertrophy of Tongue Papillae according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 10.08 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
2 oxidoreductase activity GO:0016491 10.02 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
3 heme binding GO:0020037 9.91 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
4 iron ion binding GO:0005506 9.87 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
5 aromatase activity GO:0070330 9.83 CYP3A4 CYP2C9 CYP2C8 CYP2C19 CYP1A2
6 arachidonic acid epoxygenase activity GO:0008392 9.76 CYP2C9 CYP2C8 CYP2C19 CYP2B6
7 enzyme binding GO:0019899 9.73 CYP3A4 CYP2C19 CYP1A2
8 steroid hydroxylase activity GO:0008395 9.73 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
9 caffeine oxidase activity GO:0034875 9.71 CYP3A4 CYP2C9 CYP2C8 CYP1A2
10 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.7 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
11 estrogen 16-alpha-hydroxylase activity GO:0101020 9.67 CYP3A4 CYP2C8 CYP1A2
12 drug binding GO:0008144 9.57 CYP2D6 CYP2C9
13 oxygen binding GO:0019825 9.55 CYP3A4 CYP2C19
14 retinoic acid 4-hydroxylase activity GO:0008401 9.52 CYP3A4 CYP2C8
15 estrogen 2-hydroxylase activity GO:0101021 9.51 CYP3A4 CYP1A2
16 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.5 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6
17 monooxygenase activity GO:0004497 9.17 CYP3A4 CYP2D6 CYP2C9 CYP2C8 CYP2C19 CYP2B6

Sources for Hypertrophy of Tongue Papillae

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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