MCID: HYP047
MIFTS: 27

Hypertropia

Categories: Neuronal diseases

Aliases & Classifications for Hypertropia

MalaCards integrated aliases for Hypertropia:

Name: Hypertropia 12 74 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:9837
ICD9CM 34 378.31
MeSH 43 D013285
NCIt 49 C34716
SNOMED-CT 67 40608009
ICD10 32 H50.2
UMLS 71 C0020575

Summaries for Hypertropia

MalaCards based summary : Hypertropia is related to hypotropia and fourth cranial nerve palsy. An important gene associated with Hypertropia is NT5C3A (5'-Nucleotidase, Cytosolic IIIA). The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and thyroid.

Wikipedia : 74 Hypertropia is a condition of misalignment of the eyes (strabismus), whereby the visual axis of one eye... more...

Related Diseases for Hypertropia

Diseases related to Hypertropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 hypotropia 31.6 TNNI3K PLAAT3 PHOX2A KIF21A ADHFE1
2 fourth cranial nerve palsy 30.3 SEMA7A NT5C3A
3 suppression amblyopia 30.2 PLAAT3 PHOX2A
4 amblyopia 30.2 PLAAT3 PHOX2A KIF21A
5 orbital disease 30.0 PHOX2A NT5C3A KIF21A
6 paralytic squint 29.7 SEMA7A PHOX2A NT5C3A KIF21A
7 esotropia 29.3 SEMA7A ROBO3 PLAAT3 PHOX2A NT5C3A KIF21A
8 ptosis 29.2 TNNI3K PHOX2A NT5C3A LAX1 KIF21A
9 exotropia 29.2 TNNI3K SEMA7A ROBO3 PLAAT3 PHOX2A NT5C3A
10 strabismus 28.7 TNNI3K SPIN1 SEMA7A ROBO3 PLAAT3 PHOX2A
11 fourth cranial nerve palsy, familial congenital 11.3
12 mechanical strabismus 10.7
13 alternating exotropia 10.6
14 monocular esotropia 10.4
15 partial third-nerve palsy 10.3 NT5C3A KIF21A
16 myasthenia gravis 10.2
17 brown syndrome 10.2
18 cranial nerve palsy 10.2
19 eye disease 10.2
20 dissociated nystagmus 10.1 ROBO3 NT5C3A
21 myotonic cataract 10.1 PHOX2A KIF21A
22 fibrosis of extraocular muscles, congenital, 2 10.1 PHOX2A KIF21A
23 abducens palsy 10.0
24 fibrosis of extraocular muscles, congenital, 1 10.0
25 glaucoma, primary open angle 10.0
26 retinal detachment 10.0
27 ataxia and polyneuropathy, adult-onset 10.0
28 open-angle glaucoma 10.0
29 hemiplegia 10.0
30 horner's syndrome 10.0
31 synostosis 10.0
32 optic nerve disease 10.0
33 hemangioma 10.0
34 intramuscular hemangioma 10.0
35 cataract 10.0
36 pathologic nystagmus 10.0
37 refractive error 10.0
38 monofixation syndrome 10.0
39 congenital abducens nerve palsy 10.0
40 cyclotropia 10.0 SEMA7A LAX1
41 accommodative esotropia 10.0 PLAAT3 PHOX2A
42 marcus gunn phenomenon 10.0 SPIN1 PHOX2A KIF21A
43 facial nerve disease 9.9 ROBO3 NT5C3A KIF21A
44 facial paralysis 9.9 NT5C3A KIF21A
45 enophthalmos 9.9 TNNI3K PHOX2A NT5C3A
46 microphthalmia, isolated 5 9.9 PHOX2A KIF21A
47 cranial nerve disease 9.8 PLAAT3 PHOX2A NT5C3A KIF21A
48 duane-radial ray syndrome 9.8 ROBO3 PHOX2A KIF21A
49 congenital ptosis 9.3 TNNI3K ROBO3 PHOX2A NT5C3A KIF21A
50 tukel syndrome 9.3 TNNI3K ROBO3 PHOX2A NT5C3A KIF21A

Graphical network of the top 20 diseases related to Hypertropia:



Diseases related to Hypertropia

Symptoms & Phenotypes for Hypertropia

Drugs & Therapeutics for Hypertropia

Drugs for Hypertropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational 51-84-3 187
2 abobotulinumtoxinA
3 Cholinergic Agents
4 Neurotransmitter Agents
5 Botulinum Toxins
6 Botulinum Toxins, Type A

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective Observational Study of Adult Strabismus Completed NCT02510040
2 Routine Care Study Evaluating Ocular Torsion Completed NCT02894411
3 Symmetrical Versus Asymmetrical Inferior Oblique Muscle Weakening Surgery for Asymmetrical Inferior Oblique Overaction Recruiting NCT03507712

Search NIH Clinical Center for Hypertropia

Genetic Tests for Hypertropia

Anatomical Context for Hypertropia

MalaCards organs/tissues related to Hypertropia:

40
Eye, Testes, Thyroid, Brain, T Cells

Publications for Hypertropia

Articles related to Hypertropia:

(show top 50) (show all 418)
# Title Authors PMID Year
1
Teleophthalmology Prevents Unnecessary Evacuation from Warzone. 61
31603234 2020
2
Contributions to the study of spinocerebellar ataxia type 38 (SCA38). 61
32314013 2020
3
Myectomy of the four horizontal rectus muscles with pulley fixation for the treatment of horizontal nystagmus in 10 adults: a pilot study. 61
32224284 2020
4
Inferior oblique belly transposition for V pattern strabismus. 61
31847669 2020
5
Binocular Diplopia Caused by an Epiretinal Membrane With Foveal Displacement. 61
31306185 2020
6
Superior oblique tendon advancement: its success as single or combined muscle treatment for selected cases of unilateral superior oblique palsy. 61
31775558 2020
7
Comparison of different tendon transposition techniques for the treatment of monocular elevation deficiency type 2. 61
31901510 2020
8
Management of stretched scar- induced secondary strabismus. 61
32075609 2020
9
Prevalence of Sagging Eye Syndrome in Adults with Binocular Diplopia. 61
31526795 2020
10
Isolated Bilateral Superior Rectii Paresis: A Rare Anomaly. 61
31839100 2019
11
A case of skew deviation and downbeat Nystagmus induced by Lithium. 61
31842796 2019
12
Clinical findings and surgical outcomes of patients with traumatic isolated inferior rectus muscle paresis. 61
31626984 2019
13
Anterior transposition of inferior oblique for inferior rectus muscle aplasia. 61
31942437 2019
14
Recurrent Superior Oblique Myokymia Treated by Distal Tendon Extirpation. 61
30289792 2019
15
Plate size reduction surgery for the Baerveldt 350-mm2 glaucoma implant for postoperative motor disturbance: A case report. 61
31517867 2019
16
Eye Conditions in Infants and Children: Amblyopia and Strabismus. 61
31454213 2019
17
Pseudo inferior oblique overaction, clinical findings, mechanism, and surgical outcomes. 61
31203518 2019
18
Quantitative analysis of structure-function relationship between ocular motility and superior oblique muscle hypoplasia in unilateral superior oblique palsy. 61
30409916 2019
19
Trochlear nerve palsy associated with Moyamoya disease. 61
31182268 2019
20
Onodi cell mucocele causing isolated trochlear nerve palsy: A case report. 61
31124930 2019
21
Outcome of inferior oblique disinsertion versus myectomy in the surgical treatment of unilateral congenital superior oblique palsy. 61
30885810 2019
22
Visual Complications of Pediatric Posterior Fossa Tumors: Analysis of Outcomes. 61
30661932 2019
23
Congenital Multiple Ocular Motor Nerve Palsy Complicated by Splitting of the Lateral Rectus Muscle. 61
30820056 2019
24
Orbital Rosai-Dorfman Disease: A Case Report and Literature Review. 61
31008056 2019
25
Surgical Outcome of Single Inferior Oblique Myectomy in Small and Large Hypertropia of Unilateral Superior Oblique Palsy. 61
30371917 2019
26
When "looks" can be deceiving - Internuclear ophthalmoplegia after mild traumatic brain injury: Case report and literature review. 61
31539826 2019
27
Inferior Oblique Muscle Overaction: Clinical Features and Surgical Management. 61
31396413 2019
28
Congenital Ocular Neuromyotonia with Partial Third Nerve Palsy. 61
30806169 2019
29
Dual-Augmented Transposition of Vertical Recti in Chronic Abducens Palsy. 61
30308205 2019
30
Idiopathic Isolated Acquired Steroid Dependent SO Palsy: A Rare Case Report. 61
30809402 2019
31
Superior Oblique Palsy: Efficacy of Isolated Inferior Oblique Recession in Cases with Ipsilateral Hypertropia in Abduction. 61
30615559 2019
32
Trapdoor orbital floor fracture and inferior rectus entrapment with minimal infraduction deficit and hypertropia. 61
30503008 2018
33
Complete inferior rectus muscle transection secondary to orbital blowout fracture. 61
29303394 2018
34
Case Report: Late Sequela of a Muslinoma Involving the Optic Chiasm. 61
30524491 2018
35
Adult-onset nonparalytic, small-angle hypertropia. 61
30321668 2018
36
Congenital Monocular Strabismus Fixus. 61
30074609 2018
37
[Isolated Unilateral Strabismus Sursoadductorius (Congenital Trochlear Palsy) with and without Hypotrophia of the Superior Oblique Muscle-Orthoptic Differences in Adulthood]. 61
29270927 2018
38
Consecutive superior oblique palsy after adjustable suture spacer surgery for Brown syndrome: incidence and predicting risk. 61
30236966 2018
39
Vertical rectus muscle recession versus combined vertical and horizontal rectus muscle recession in patients with thyroid eye disease and hypotropia. 61
30031873 2018
40
IgG4-related ophthalmic disease involving extraocular muscles: case series. 61
29970061 2018
41
Immediate Postoperative Alignment Measurements as a Predictor of Alignment Stability in Fixed Suture Strabismus Surgery. 61
29709042 2018
42
Vertical diplopia and oscillopsia due to midbrain keyhole aqueduct syndrome associated with severe cough. 61
29687086 2018
43
Optic Nerve Sheath Tethering in Adduction Occurs in Esotropia and Hypertropia, But Not in Exotropia. 61
30025141 2018
44
Simultaneous Superior Rectus Recession and Anterior Transposition of Inferior Oblique Muscle as a Surgical Option for Traumatically Lost Inferior Rectus Muscle. 61
29485307 2018
45
Comparative study of unilateral versus bilateral inferior oblique recession/anteriorization in unilateral inferior oblique overaction. 61
29077192 2018
46
Stereopsis before and after Inferior Oblique Weakening Surgery. 61
29560617 2018
47
Differentiating Acute and Subacute Vertical Strabismus Using Different Head Positions During the Upright-Supine Test. 61
29450486 2018
48
Long-term Surgical Outcomes in the Sagging Eye Syndrome. 61
29297726 2018
49
Incidence and Risk Factors of Inferior Rectus Muscle Palsy in Pediatric Orbital Blowout Fractures. 61
29387301 2018
50
Treatment of Small Angle Hypertropia With Inferior Oblique Overaction. 61
29378079 2018

Variations for Hypertropia

Expression for Hypertropia

Search GEO for disease gene expression data for Hypertropia.

Pathways for Hypertropia

GO Terms for Hypertropia

Biological processes related to Hypertropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide metabolic process GO:0009117 8.62 NT5C3A ADAL

Sources for Hypertropia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....