MCID: HYP047
MIFTS: 29

Hypertropia

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Hypertropia

MalaCards integrated aliases for Hypertropia:

Name: Hypertropia 12 77 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:9837
ICD9CM 36 378.31
MeSH 45 D013285
NCIt 51 C34716
SNOMED-CT 69 40608009
ICD10 34 H50.2
UMLS 74 C0020575

Summaries for Hypertropia

MalaCards based summary : Hypertropia is related to hypotropia and strabismus. An important gene associated with Hypertropia is KIF21A (Kinesin Family Member 21A). The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include eye.

Wikipedia : 77 Hypertropia is a condition of misalignment of the eyes (strabismus), whereby the visual axis of one eye... more...

Related Diseases for Hypertropia

Diseases related to Hypertropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 hypotropia 31.9 KANTR KIF21A SAMHD1
2 strabismus 30.2 FGFR2 FGFR3 KIF21A
3 fourth cranial nerve palsy, familial congenital 11.1
4 exotropia 10.4
5 hemifacial hyperplasia 10.2 FGFR2 FGFR3
6 plagiocephaly 10.2 FGFR2 FGFR3
7 osteoglophonic dysplasia 10.2 FGFR2 FGFR3
8 luteoma 10.2 FGFR2 FGFR3
9 petroclival meningioma 10.2 KANTR NT5C3A
10 beare-stevenson cutis gyrata syndrome 10.2 FGFR2 FGFR3
11 brachial plexus neuritis 10.1 FOXL2 KANTR
12 jackson-weiss syndrome 10.1 FGFR2 FGFR3
13 anteroseptal myocardial infarction 10.1 HTRA2 KANTR
14 ocular motility disease 10.1 KANTR KIF21A NT5C3A
15 radioulnar synostosis 10.1 FGFR2 FGFR3
16 facial nerve disease 10.1 KANTR KIF21A
17 crouzon syndrome 10.0 ALX3 FGFR2 FGFR3
18 substernal goiter 10.0 KANTR TG
19 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.0 FGFR2 TG
20 paralytic squint 10.0 KANTR KIF21A SAMHD1
21 amyloid tumor 10.0 TG TTR
22 abducens nerve disease 10.0 KANTR SAMHD1
23 brown-sequard syndrome 10.0 KANTR TTR
24 abducens palsy 10.0
25 retinal detachment 10.0
26 cataract 10.0
27 hemangioma 10.0
28 monocular esotropia 10.0
29 amblyopia 10.0
30 alternating exotropia 10.0
31 synostosis 10.0
32 intramuscular hemangioma 10.0
33 esotropia 10.0
34 peripheral nervous system disease 9.9 KANTR KIF21A TTR
35 thanatophoric dysplasia, type i 9.9 FGFR2 FGFR3
36 exophthalmos 9.9 FGFR2 FGFR3 TG
37 hypochondroplasia 9.8 FGFR2 FGFR3
38 thyroid crisis 9.8 KANTR TG TTR
39 hydrocephalus 9.7 FGFR2 FGFR3 TTR

Graphical network of the top 20 diseases related to Hypertropia:



Diseases related to Hypertropia

Symptoms & Phenotypes for Hypertropia

Drugs & Therapeutics for Hypertropia

Drugs for Hypertropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational 51-84-3 187
2 abobotulinumtoxinA
3 Botulinum Toxins
4 Acetylcholine Release Inhibitors
5 Cholinergic Agents
6 Neurotransmitter Agents
7 Botulinum Toxins, Type A

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective Observational Study of Adult Strabismus Completed NCT02510040
2 Routine Care Study Evaluating Ocular Torsion Recruiting NCT02894411

Search NIH Clinical Center for Hypertropia

Genetic Tests for Hypertropia

Anatomical Context for Hypertropia

MalaCards organs/tissues related to Hypertropia:

42
Eye

Publications for Hypertropia

Articles related to Hypertropia:

(show top 50) (show all 66)
# Title Authors Year
1
Surgical Outcome of Single Inferior Oblique Myectomy in Small and Large Hypertropia of Unilateral Superior Oblique Palsy. ( 30371917 )
2019
2
Superior Oblique Palsy: Efficacy of Isolated Inferior Oblique Recession in Cases with Ipsilateral Hypertropia in Abduction. ( 30615559 )
2019
3
Inferior Oblique Belly Transposition for Small Angle Hypertropia With Inferior Oblique Overaction: A Pilot Study. ( 28991348 )
2018
4
Treatment of Small Angle Hypertropia With Inferior Oblique Overaction. ( 29378079 )
2018
5
Optic Nerve Sheath Tethering in Adduction Occurs in Esotropia and Hypertropia, But Not in Exotropia. ( 30025141 )
2018
6
Adult-onset nonparalytic, small-angle hypertropia. ( 30321668 )
2018
7
Trapdoor orbital floor fracture and inferior rectus entrapment with minimal infraduction deficit and hypertropia. ( 30503008 )
2018
8
Resolution of hypertropia with correction of consecutive horizontal deviation. ( 28499831 )
2017
9
Comparing Hypertropia in Upgaze and Downgaze Distinguishes Congenital From Acquired Fourth Nerve Palsies. ( 27787462 )
2016
10
Teaching Video NeuroImages: Alternating skew deviation with abducting hypertropia following superior colliculus infarction. ( 26928363 )
2016
11
Inferior oblique anterior transposition for the unilateral hypertropia associated with bilateral inferior rectus muscle aplasia. ( 24767828 )
2014
12
Accuracy of double maddox rod with induced hypertropia in normal subjects. ( 25313115 )
2014
13
Hypertropia in unilateral isolated abducens palsy. ( 24924275 )
2014
14
Isolated inferior oblique myectomy for hypertropia. ( 25603661 )
2014
15
Location and Gaze-dependent Shift of Inferior Oblique Muscle Position: Anatomical Contributors to Hypertropia Following Lower Lid Blepharoplasty? ( 25477320 )
2014
16
Resolution of hypertropia with correction of intermittent exotropia. ( 23934140 )
2013
17
Combined resection and anterior transposition of the inferior oblique muscle for treatment of large primary position hypertropia caused by unilateral superior oblique muscle palsy. ( 23993717 )
2013
18
Relationship of hypertropia and excyclotorsion in superior oblique palsy. ( 23372378 )
2013
19
Inferior oblique transposition for large hypertropia after vertical rectus transposition. ( 23618631 )
2013
20
Hypertropia following Spontaneous Resolution of Brown's Syndrome. ( 22855678 )
2012
21
Adult hypertropia: a guide to diagnostic evaluation based on review of 300 patients. ( 21057518 )
2011
22
Functional imaging of human extraocular muscles in head tilt dependent hypertropia. ( 21282574 )
2011
23
Surgical management of clinically significant hypertropia associated with exotropia. ( 20603056 )
2010
24
Scleral Graft and Muscle Transposition in the Treatment of Scleromalacia and Hypertropia Following Retinal Detachment Surgery. ( 20337346 )
2010
25
'Surgical outcomes of intermittent exotropia associated with concomitant hypertropia including simulated superior oblique palsy after horizontal muscles surgery only' by YA Cho and S-H Kim. ( 18670464 )
2008
26
Surgical management for large hypertropia and exotropia after disinsertion of inferior rectus muscle. ( 19065984 )
2008
27
Unilateral myelinated nerve fibers associated with hypertropia, strabismus and amblyopia? Reverse straatsma syndrome? ( 19132949 )
2008
28
Treatment of incomitant hypertropia and diplopia with recession of the inferior rectus and superior rectus muscles of the same eye. ( 17572341 )
2007
29
Surgical outcomes of intermittent exotropia associated with concomitant hypertropia including simulated superior oblique palsy after horizontal muscles surgery only. ( 17016462 )
2007
30
A case of intramuscular hemangioma presenting with large-angle hypertropia. ( 17004637 )
2006
31
Incidence and types of childhood hypertropia: a population-based study. ( 16647125 )
2006
32
Hypertropia associated with superolateral translation of the superior rectus muscle pulley in unilateral coronal synostosis. ( 16908815 )
2006
33
Unilateral anterior transposition and resection of the inferior oblique muscle for the treatment of hypertropia. ( 15977869 )
2005
34
Inferior rectus pulley hindrance: a mechanism of restrictive hypertropia following lower lid surgery. ( 15314594 )
2004
35
Graded partial tenotomy of vertical rectus muscles for treatment of hypertropia. ( 15747755 )
2004
36
Unilateral anterior transposition of the inferior oblique muscle for correction of hypertropia in primary position. ( 12917609 )
2003
37
Grand rounds #65: a case of a left hypertropia which decreases markedly in both upgaze and downgaze. ( 11874381 )
2002
38
Grand rounds #66: a case of a residual left hypertropia after surgery for a paralysis of the inferior division of the 3rd nerve. ( 12067267 )
2002
39
Two entities in which a dissociative hypertropia may present after surgery. ( 11874375 )
2002
40
Monofixation with eso-, exo-, or hypertropia: is there a difference? ( 21149032 )
2001
41
Anterior transposition of the superior oblique tendon in the treatment of oculomotor nerve palsy and its influence on postoperative hypertropia. ( 10845415 )
2000
42
Grand rounds #52: a case of a residual left exotropia and hypertropia after previous surgery for a third nerve palsy. ( 9852443 )
1998
43
Hypertropia and the posterior blowout fracture: Mechanism and management. ( 8628546 )
1996
44
Ipsilateral hypertropia after cataract surgery. ( 8637680 )
1996
45
Hypertropia and the posterior blowout fracture. ( 8684811 )
1996
46
Unilateral congenital fibrosis syndrome presenting with hypertropia. ( 8154269 )
1993
47
Hypertropia following trochlear trauma. ( 1432500 )
1992
48
Hypertropia following insertion of inferiorly sited double-plate Molteno tubes. ( 1286718 )
1992
49
Hypertropia after implantation of a Molteno drainage device. ( 1728155 )
1992
50
Alternating skew on lateral gaze (bilateral abducting hypertropia). ( 3377440 )
1988

Variations for Hypertropia

Expression for Hypertropia

Search GEO for disease gene expression data for Hypertropia.

Pathways for Hypertropia

GO Terms for Hypertropia

Biological processes related to Hypertropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of multicellular organism growth GO:0040014 9.26 FGFR2 HTRA2
2 ceramide metabolic process GO:0006672 9.16 FUT3 HTRA2
3 positive regulation of phospholipase activity GO:0010518 8.96 FGFR2 FGFR3
4 endochondral bone growth GO:0003416 8.62 FGFR2 FGFR3

Molecular functions related to Hypertropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibroblast growth factor binding GO:0017134 8.96 FGFR2 FGFR3
2 fibroblast growth factor-activated receptor activity GO:0005007 8.62 FGFR2 FGFR3

Sources for Hypertropia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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