MCID: HYP047
MIFTS: 33

Hypertropia

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Hypertropia

MalaCards integrated aliases for Hypertropia:

Name: Hypertropia 12 76 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9837
ICD10 33 H50.2
ICD9CM 35 378.31
MeSH 44 D013285
NCIt 50 C34716
SNOMED-CT 68 40608009
UMLS 73 C0020575

Summaries for Hypertropia

MalaCards based summary : Hypertropia is related to hypotropia and exotropia. An important gene associated with Hypertropia is CHN1 (Chimerin 1), and among its related pathways/superpathways is Cytoskeleton remodeling_RalB regulation pathway. The drugs Acetylcholine and Botulinum Toxins, Type A have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and thyroid, and related phenotypes are Dynamic nuclei (hole, folded or small irregular) and limbs/digits/tail

Wikipedia : 76 Hypertropia is a condition of misalignment of the eyes (strabismus), whereby the visual axis of one eye... more...

Related Diseases for Hypertropia

Diseases related to Hypertropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 hypotropia 31.6 CHN1 KANTR KIF21A SAMHD1 TUBB3
2 exotropia 30.8 CHN1 KIF21A TUBB3
3 amblyopia 30.1 CHN1 FOXL2 TUBB3
4 strabismus 30.0 CHN1 FGFR2 FGFR3 KIF21A TUBB3
5 fourth cranial nerve palsy, familial congenital 11.1
6 hemifacial hyperplasia 10.2 FGFR2 FGFR3
7 plagiocephaly 10.2 FGFR2 FGFR3
8 osteoglophonic dysplasia 10.2 FGFR2 FGFR3
9 marcus gunn phenomenon 10.2 CHN1 TUBB3
10 luteoma 10.2 FGFR2 FGFR3
11 beare-stevenson cutis gyrata syndrome 10.2 FGFR2 FGFR3
12 alternating esotropia 10.2 CHN1 KANTR
13 accommodative esotropia 10.1 CHN1 KANTR
14 oculomotor nerve paralysis 10.1 CHN1 KANTR
15 congenital ptosis 10.1 CHN1 KIF21A TUBB3
16 third cranial nerve disease 10.1 CHN1 KANTR
17 deafness, autosomal dominant 28 10.1 CHN1 KIF21A TUBB3
18 jackson-weiss syndrome 10.1 FGFR2 FGFR3
19 tukel syndrome 10.1 CHN1 KIF21A TUBB3
20 moebius syndrome 10.1 FOXL2 TUBB3
21 ptosis 10.1 FOXL2 KIF21A TUBB3
22 crouzon syndrome 10.1 ALX3 FGFR2 FGFR3
23 brachial plexus neuritis 10.1 FOXL2 KANTR
24 radioulnar synostosis 10.1 FGFR2 FGFR3
25 dental abscess 10.1 ACP5 KANTR
26 abducens nerve disease 10.1 CHN1 KANTR SAMHD1
27 substernal goiter 10.0 KANTR TG
28 duane retraction syndrome 10.0 CHN1 FOXL2 KIF21A TUBB3
29 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.0 FGFR2 TG
30 thanatophoric dysplasia, type i 10.0 FGFR2 FGFR3
31 facial nerve disease 10.0 KANTR KIF21A TUBB3
32 exposure keratitis 10.0 KANTR TUBB3
33 brown-sequard syndrome 10.0 KANTR TTR
34 exophthalmos 10.0 FGFR2 FGFR3 TG
35 abducens palsy 10.0
36 retinal detachment 10.0
37 cataract 10.0
38 hemangioma 10.0
39 monocular esotropia 10.0
40 alternating exotropia 10.0
41 synostosis 10.0
42 intramuscular hemangioma 10.0
43 esotropia 10.0
44 ocular motility disease 9.9 CHN1 KANTR KIF21A TUBB3
45 cranial nerve disease 9.9 CHN1 KANTR KIF21A TUBB3
46 nervous system disease 9.9 KANTR TTR TUBB3
47 amyloid tumor 9.9 TG TTR TUBB3
48 thyroid crisis 9.9 KANTR TG TTR
49 hydrocephalus 9.9 FGFR2 FGFR3 TTR
50 paralytic squint 9.8 CHN1 KANTR KIF21A SAMHD1 TUBB3

Graphical network of the top 20 diseases related to Hypertropia:



Diseases related to Hypertropia

Symptoms & Phenotypes for Hypertropia

GenomeRNAi Phenotypes related to Hypertropia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Dynamic nuclei (hole, folded or small irregular) GR00257-A-1 9.23 ALX3 CHN1 FGFR2 FGFR3 FOXL2 TG

MGI Mouse Phenotypes related to Hypertropia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.1 ALX3 DUSP4 FGFR2 FGFR3 KNTC1 TG

Drugs & Therapeutics for Hypertropia

Drugs for Hypertropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved 51-84-3 187
2 Botulinum Toxins, Type A
3 Acetylcholine Release Inhibitors
4 onabotulinumtoxinA
5 Cholinergic Agents
6 Botulinum Toxins
7 Neurotransmitter Agents
8 abobotulinumtoxinA

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Routine Care Study Evaluating Ocular Torsion Recruiting NCT02894411
2 A Prospective Observational Study of Adult Strabismus Active, not recruiting NCT02510040

Search NIH Clinical Center for Hypertropia

Genetic Tests for Hypertropia

Anatomical Context for Hypertropia

MalaCards organs/tissues related to Hypertropia:

41
Eye, Bone, Thyroid

Publications for Hypertropia

Articles related to Hypertropia:

(show top 50) (show all 65)
# Title Authors Year
1
Inferior Oblique Belly Transposition for Small Angle Hypertropia With Inferior Oblique Overaction: A Pilot Study. ( 28991348 )
2018
2
Treatment of Small Angle Hypertropia With Inferior Oblique Overaction. ( 29378079 )
2018
3
Optic Nerve Sheath Tethering in Adduction Occurs in Esotropia and Hypertropia, But Not in Exotropia. ( 30025141 )
2018
4
Adult-onset nonparalytic, small-angle hypertropia. ( 30321668 )
2018
5
Surgical Outcome of Single Inferior Oblique Myectomy in Small and Large Hypertropia of Unilateral Superior Oblique Palsy. ( 30371917 )
2018
6
Trapdoor orbital floor fracture and inferior rectus entrapment with minimal infraduction deficit and hypertropia. ( 30503008 )
2018
7
Resolution of hypertropia with correction of consecutive horizontal deviation. ( 28499831 )
2017
8
Comparing Hypertropia in Upgaze and Downgaze Distinguishes Congenital From Acquired Fourth Nerve Palsies. ( 27787462 )
2016
9
Teaching Video NeuroImages: Alternating skew deviation with abducting hypertropia following superior colliculus infarction. ( 26928363 )
2016
10
Inferior oblique anterior transposition for the unilateral hypertropia associated with bilateral inferior rectus muscle aplasia. ( 24767828 )
2014
11
Accuracy of double maddox rod with induced hypertropia in normal subjects. ( 25313115 )
2014
12
Hypertropia in unilateral isolated abducens palsy. ( 24924275 )
2014
13
Isolated inferior oblique myectomy for hypertropia. ( 25603661 )
2014
14
Location and Gaze-dependent Shift of Inferior Oblique Muscle Position: Anatomical Contributors to Hypertropia Following Lower Lid Blepharoplasty? ( 25477320 )
2014
15
Resolution of hypertropia with correction of intermittent exotropia. ( 23934140 )
2013
16
Combined resection and anterior transposition of the inferior oblique muscle for treatment of large primary position hypertropia caused by unilateral superior oblique muscle palsy. ( 23993717 )
2013
17
Relationship of hypertropia and excyclotorsion in superior oblique palsy. ( 23372378 )
2013
18
Inferior oblique transposition for large hypertropia after vertical rectus transposition. ( 23618631 )
2013
19
Hypertropia following Spontaneous Resolution of Brown's Syndrome. ( 22855678 )
2012
20
Adult hypertropia: a guide to diagnostic evaluation based on review of 300 patients. ( 21057518 )
2011
21
Functional imaging of human extraocular muscles in head tilt dependent hypertropia. ( 21282574 )
2011
22
Surgical management of clinically significant hypertropia associated with exotropia. ( 20603056 )
2010
23
Scleral Graft and Muscle Transposition in the Treatment of Scleromalacia and Hypertropia Following Retinal Detachment Surgery. ( 20337346 )
2010
24
'Surgical outcomes of intermittent exotropia associated with concomitant hypertropia including simulated superior oblique palsy after horizontal muscles surgery only' by YA Cho and S-H Kim. ( 18670464 )
2008
25
Surgical management for large hypertropia and exotropia after disinsertion of inferior rectus muscle. ( 19065984 )
2008
26
Unilateral myelinated nerve fibers associated with hypertropia, strabismus and amblyopia? Reverse straatsma syndrome? ( 19132949 )
2008
27
Treatment of incomitant hypertropia and diplopia with recession of the inferior rectus and superior rectus muscles of the same eye. ( 17572341 )
2007
28
Surgical outcomes of intermittent exotropia associated with concomitant hypertropia including simulated superior oblique palsy after horizontal muscles surgery only. ( 17016462 )
2007
29
A case of intramuscular hemangioma presenting with large-angle hypertropia. ( 17004637 )
2006
30
Incidence and types of childhood hypertropia: a population-based study. ( 16647125 )
2006
31
Hypertropia associated with superolateral translation of the superior rectus muscle pulley in unilateral coronal synostosis. ( 16908815 )
2006
32
Unilateral anterior transposition and resection of the inferior oblique muscle for the treatment of hypertropia. ( 15977869 )
2005
33
Inferior rectus pulley hindrance: a mechanism of restrictive hypertropia following lower lid surgery. ( 15314594 )
2004
34
Graded partial tenotomy of vertical rectus muscles for treatment of hypertropia. ( 15747755 )
2004
35
Unilateral anterior transposition of the inferior oblique muscle for correction of hypertropia in primary position. ( 12917609 )
2003
36
Grand rounds #65: a case of a left hypertropia which decreases markedly in both upgaze and downgaze. ( 11874381 )
2002
37
Grand rounds #66: a case of a residual left hypertropia after surgery for a paralysis of the inferior division of the 3rd nerve. ( 12067267 )
2002
38
Two entities in which a dissociative hypertropia may present after surgery. ( 11874375 )
2002
39
Monofixation with eso-, exo-, or hypertropia: is there a difference? ( 21149032 )
2001
40
Anterior transposition of the superior oblique tendon in the treatment of oculomotor nerve palsy and its influence on postoperative hypertropia. ( 10845415 )
2000
41
Grand rounds #52: a case of a residual left exotropia and hypertropia after previous surgery for a third nerve palsy. ( 9852443 )
1998
42
Hypertropia and the posterior blowout fracture: Mechanism and management. ( 8628546 )
1996
43
Ipsilateral hypertropia after cataract surgery. ( 8637680 )
1996
44
Hypertropia and the posterior blowout fracture. ( 8684811 )
1996
45
Unilateral congenital fibrosis syndrome presenting with hypertropia. ( 8154269 )
1993
46
Hypertropia following trochlear trauma. ( 1432500 )
1992
47
Hypertropia following insertion of inferiorly sited double-plate Molteno tubes. ( 1286718 )
1992
48
Hypertropia after implantation of a Molteno drainage device. ( 1728155 )
1992
49
Alternating skew on lateral gaze (bilateral abducting hypertropia). ( 3377440 )
1988
50
Superior oblique strengthening procedures in hypertropia I and II. ( 438930 )
1979

Variations for Hypertropia

Expression for Hypertropia

Search GEO for disease gene expression data for Hypertropia.

Pathways for Hypertropia

Pathways related to Hypertropia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.95 CHN1 FGFR2 FGFR3

GO Terms for Hypertropia

Biological processes related to Hypertropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of phospholipase activity GO:0010518 9.16 FGFR2 FGFR3
2 endochondral bone growth GO:0003416 8.96 FGFR2 FGFR3
3 bone morphogenesis GO:0060349 8.8 ACP5 FGFR2 FGFR3

Molecular functions related to Hypertropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibroblast growth factor binding GO:0017134 8.96 FGFR2 FGFR3
2 fibroblast growth factor-activated receptor activity GO:0005007 8.62 FGFR2 FGFR3

Sources for Hypertropia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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