Hypervitaminosis a disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Disease Ontology: ¹¹ An overnutrition that is characterized by excess vitamin A, has symptom hepatomegaly, anorexia, fever, alopecia, and arthralgia, and has material basis in excessive intake of vitaimin A, and/or derangement of vitamin A metabolism.

MalaCards based summary: Hypervitaminosis a, also known as hypervitaminosis a, susceptibility to, is related to keratomalacia and neural tube defects, and has symptoms including hepatomegaly An important gene associated with Hypervitaminosis a is RBP4 (Retinol Binding Protein 4), and among its related pathways/superpathways are Disease and Metabolism. The drugs Vitamin A and Vitamins have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and skin, and related phenotypes are increased intracranial pressure and renal insufficiency

Wikipedia: ⁷⁵ Hypervitaminosis A refers to the toxic effects of ingesting too much preformed vitamin A (retinyl... more...

More information from OMIM: 240150

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Related Diseases for Hypervitaminosis a

Diseases in the Hypervitaminosis a family:

Hypervitaminosis D

Diseases related to Hypervitaminosis a via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)

#	Related Disease	Score	Top Affiliating Genes
1	keratomalacia	30.8	TTR RBP4 RARS1 LRAT CYP26A1
2	neural tube defects	28.6	CYP26B1 CYP26A1 CRABP2 CRABP1
3	intracranial hypertension, idiopathic	10.4
4	cleft palate, isolated	10.4
5	intracranial hypertension	10.3
6	hyperostosis	10.3
7	acne	10.3
8	hydrocephalus	10.2
9	chronic kidney disease	10.2
10	cystic fibrosis	10.2
11	papilledema	10.2
12	kidney disease	10.2
13	exencephaly	10.2
14	caffey disease	10.1
15	autism	10.1
16	portal hypertension	10.1
17	exostosis	10.1
18	liver cirrhosis	10.1
19	alopecia	10.1
20	amyloidosis, hereditary, transthyretin-related	10.0	TTR RBP4
21	spondylosis, cervical	10.0
22	hypoascorbemia	10.0
23	deficiency anemia	10.0
24	autism spectrum disorder	10.0
25	anencephaly	10.0
26	meningocele	10.0
27	microcephaly	10.0
28	hydronephrosis	10.0
29	vitamin k deficiency bleeding	10.0
30	hyperparathyroidism	10.0
31	spondylosis	10.0
32	ankylosis	10.0
33	acute kidney failure	10.0
34	hypervitaminosis d	10.0
35	encephalocele	10.0
36	optic nerve hypoplasia, bilateral	10.0	CYP26B1 CYP26A1
37	carotenemia	9.9	TTR CYP26A1 BCO1
38	gastroesophageal reflux	9.8
39	bladder cancer	9.8
40	alagille syndrome 1	9.8
41	osseous heteroplasia, progressive	9.8
42	varicose veins	9.8
43	biotinidase deficiency	9.8
44	osteopetrosis, autosomal recessive 3	9.8
45	fryns microphthalmia syndrome	9.8
46	fanconi anemia, complementation group e	9.8
47	hyperhomocysteinemia	9.8
48	bulimia nervosa	9.8
49	prothrombin deficiency, congenital	9.8
50	hyperphosphatemia	9.8

Graphical network of the top 20 diseases related to Hypervitaminosis a:

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Symptoms & Phenotypes for Hypervitaminosis a

Human phenotypes related to Hypervitaminosis a:

³⁰ (show all 10)

#	Description	HPO Source Accession
1	increased intracranial pressure ³⁰	HP:0002516
2	renal insufficiency ³⁰	HP:0000083
3	ascites ³⁰	HP:0001541
4	abnormality of the liver ³⁰	HP:0001392
5	hypercalcemia ³⁰	HP:0003072
6	alopecia totalis ³⁰	HP:0007418
7	abnormality of the coagulation cascade ³⁰	HP:0003256
8	nausea ³⁰	HP:0002018
9	papilledema ³⁰	HP:0001085
10	lower limb pain ³⁰	HP:0012514

Symptoms via clinical synopsis from OMIM®:

⁵⁷ (Updated 08-Dec-2022)

H E E N T:
increased intracranial pressure
papilledema
splayed cranial sutures

Lab:
hypercalcemia

G U:
renal failure

Heme:
coagulopathy

G I:
ascites
nausea
liver disease

Skin:
alopecia totalis
erythematous, exfoliative rash

Skel:
leg pain
periosteal new bone formation

Clinical features from OMIM®:

240150 (Updated 08-Dec-2022)

Symptoms:

¹¹

• hepatomegaly

MGI Mouse Phenotypes related to Hypervitaminosis a:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10	BCO1 CDKN1A CDKN1B CRABP1 CYP26B1 LRAT
2	no phenotypic analysis	MP:0003012	9.8	CDKN1A CDKN1B CYP26A1 ISX STRA6 TTR
3	reproductive system	MP:0005389	9.56	CDKN1A CDKN1B CRABP1 CYP26A1 CYP26B1 LRAT
4	hearing/vestibular/ear	MP:0005377	9.55	CDKN1A CDKN1B CRABP1 CRABP2 RBP1
5	vision/eye	MP:0005391	9.28	CDKN1A CDKN1B CRABP1 CYP26B1 LRAT RBP1

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Drugs & Therapeutics for Hypervitaminosis a

Drugs for Hypervitaminosis a (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Vitamin A

Approved, Nutraceutical, Vet_approved

22737-96-8, 68-26-8

5280382 445354

2

Vitamins

3

Liver Extracts

4

Retinol palmitate

5

Trace Elements

6

Micronutrients

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Niveles de Retinol Hepatico y óseo en cadáveres de Adolescentes y Adultos Guatemaltecos (Liver and Bone Retinol Levels in Guatemalan Adolescents and Adults)	Unknown status	NCT04438200
2	Total Body Vitamin A Pool Size in Preschool Children Before and After Vitamin A Supplementation in an Impoverished South African Community Where Liver is Frequently Eaten and Children Exposed to Vitamin A Fortified Staple Foods	Completed	NCT02915731

Search NIH Clinical Center for Hypervitaminosis a

Cochrane evidence based reviews: hypervitaminosis a

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Genetic Tests for Hypervitaminosis a

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Anatomical Context for Hypervitaminosis a

Organs/tissues related to Hypervitaminosis a:

MalaCards : Liver, Bone, Skin, Testes, Bone Marrow, Smooth Muscle, Small Intestine

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Publications for Hypervitaminosis a

Articles related to Hypervitaminosis a:

(show top 50) (show all 762)

#	Title	Authors	PMID	Year
1	Severe hypervitaminosis A in siblings: evidence of variable tolerance to retinol intake. ⁶² ⁵⁷	Carpenter TO...Anast CS	3655980	1987
2	Unusual presentation of vitamin A intoxication. ⁵⁷	Schurr D...Abrahamov A	6644452	1983
3	Analysis of normal and truncated holo- and apo-retinol-binding protein (RBP) in human serum: altered ratios in chronic renal failure. ⁵³ ⁶²	Jaconi S...Siegenthaler G	8664978	1996
4	Serum levels of vitamin A and retinol binding protein in chronic renal patients treated by continuous ambulatorial peritoneal dialysis. ⁵³ ⁶²	Vannucchi MT...Humphreys M	1517032	1992
5	Peeling away from hypervitaminosis A: the importance of close monitoring in patients taking high dose vitamin A supplementation. ⁶²	Eldredge JA...McGrath KH	36356936	2022
6	Did hypervitaminosis A have a role in Mawson's ill-fated Antarctic exploration? ⁶²	Horowitz BZ	36286587	2022
7	Total Liver Vitamin a Reserves Are Similar Among Tanzanian Preschool Children Determined with 13C2-Retinol Isotope Dilution in Low and High Vitamin a Exposure Areas. ⁶²	Urio EM...Ndossi GD	36178059	2022
8	Filipino Children with High Usual Vitamin A Intakes and Exposure to Multiple Sources of Vitamin A Have Elevated Total Body Stores of Vitamin A But Do Not Show Clear Evidence of Vitamin A Toxicity. ⁶²	Engle-Stone R...Haskell MJ	36060221	2022
9	Structural changes of erythrocyte membrane revealed by 3D confocal optical profilometer. ⁶²	Lomanovskaya TA...Yatskovskiy AN	36056822	2022
10	Biochemical markers and anthropometric profile of children enrolled in public daycare centers. ⁶²	Lourencao LFP...Pereira-Dourado SM	34774468	2022
11	Hypervitaminosis A in Pediatric Patients With Advanced Chronic Kidney Disease. ⁶²	Harris M...Erkan E	34103212	2022
12	Hypervitaminosis A with fulminant secondary intracranial hypertension following personalized medicine-based Elexacaftor/Tezacaftor/Ivacaftor initiation in a preadolescent with cystic fibrosis. ⁶²	Wisniewski BL...Paul GR	35131172	2022
13	Chronic and acute hypervitaminosis A are associated with suboptimal anthropometric measurements in a cohort of South African preschool children. ⁶²	Sheftel J...Tanumihardjo SA	35030234	2022
14	Papilledema and hypervitaminosis A after elexacaftor/tezacaftor/ivacaftor for cystic fibrosis. ⁶²	Miller MJ...Foroozan R	34058144	2022
15	[The development of portal hypertension and liver failure on the background of long-term intake of vitamin A in a young woman. Case report]. ⁶²	Arisheva OS...Markova MA	36286747	2022
16	Prevalence of vitamin A deficiency and dietary inadequacy in Indian school-age children and adolescents. ⁶²	Reddy GB...Sachdev HS	34251518	2022
17	Liver Damage and Exposure to Toxic Concentrations of Endogenous Retinoids in the Pathogenesis of COVID-19 Disease: Hypothesis. ⁶²	Mawson AR...Gonzalez-Fernandez F	33983857	2021
18	CFTR Modulator Therapy with Lumacaftor/Ivacaftor Alters Plasma Concentrations of Lipid-Soluble Vitamins A and E in Patients with Cystic Fibrosis. ⁶²	Sommerburg O...Stahl M	33808590	2021
19	CT and MRI characteristics of presumptive hypervitaminosis A in a cat. ⁶²	Yu Y...Hasegawa D	33796325	2021
20	Adequate vitamin A liver stores estimated by the modified relative dose response test are positively associated with breastfeeding but not vitamin A supplementation in Senegalese urban children 9-23 months old: A comparative cross-sectional study. ⁶²	Faye MH...Tanumihardjo SA	33513162	2021
21	Hypervitaminosis A Following the Ingestion of Fish Liver: Report on 3 Cases from the Poison Control Center in Marseille. ⁶²	Schmitt C...Simon N	32861618	2020
22	Multiple Vaccinations and the Enigma of Vaccine Injury. ⁶²	Mawson AR...Croft AM	33198395	2020
23	Hypervitaminosis A is associated with immunological non-response in HIV-1-infected adults: a case-control study. ⁶²	Melliez H...Seguy D	32607910	2020
24	Hypercalcemia from hypervitaminosis A in a child with autism. ⁶²	O'Neal S...Dayton K	32658863	2020
25	Myositis, rhabdomyolysis and severe hypercalcaemia in a body builder. ⁶²	Ravindran R...Adlan M	32698126	2020
26	Liver toxicity from vitamin A. ⁶²	Fox R...French C	32280780	2020
27	Vitamin A administration in lizards during tail regeneration determines epithelial mucogenesis and delays muscle and cartilage differentiation. ⁶²	Alibardi L	31631512	2020
28	The Antagonist of Retinoic Acid Receptor α, ER-50891 Antagonizes the Inhibitive Effect of All-Trans Retinoic Acid and Rescues Bone Morphogenetic Protein 2-Induced Osteoblastogenic Differentiation. ⁶²	Wang S...Xu X	32158187	2020
29	Is it time for South Africa to end the routine high-dose vitamin A supplementation programme? ⁶²	Coutsoudis A...Benn CS	31865950	2019
30	Rubella Virus Infection, the Congenital Rubella Syndrome, and the Link to Autism. ⁶²	Mawson AR...Croft AM	31546693	2019
31	South African preschool children habitually consuming sheep liver and exposed to vitamin A supplementation and fortification have hypervitaminotic A liver stores: a cohort study. ⁶²	van Stuijvenberg ME...Tanumihardjo SA	31089689	2019
32	Overlapping vitamin A interventions in the United States, Guatemala, Zambia, and South Africa: case studies. ⁶²	Tanumihardjo SA...van Stuijvenberg ME	30265402	2019
33	Correction osteotomy for bilateral varus knee deformity caused by premature epiphyseal closure induced by hypervitaminosis A: a case report. ⁶²	Matsuoka M...Iwasaki N	31202274	2019
34	Restricting vitamin A intake increases bone formation in Zambian children with high liver stores of vitamin. ⁶²	Tanumihardjo SA...Binkley NC	31254130	2019
35	Retinol isotope dilution accurately predicts liver reserves in piglets but overestimates reserves in lactating sows. ⁶²	Sheftel J...Tanumihardjo SA	30889962	2019
36	Vitamin A decreases the anabolic bone response to mechanical loading by suppressing bone formation. ⁶²	Lionikaite V...Lerner UH	30668919	2019
37	Gulf War Illness: Unifying Hypothesis for a Continuing Health Problem. ⁶²	Mawson AR...Croft AM	30609834	2019
38	Spectrum of Voriconazole-Induced Periostitis With Review of the Differential Diagnosis. ⁶²	Tan I...Mar WA	30403528	2019
39	The Need to Consider Context in the Evaluation of Anti-infectious and Immunomodulatory Effects of Vitamin A and its Derivatives. ⁶²	Xavier-Elsas P...Gaspar-Elsas MIC	30556501	2019
40	Acute hypervitaminosis A misdiagnosed as malaria in a 7-year-old Nigerian boy. ⁶²	Babatola AO...Alfred A	31372061	2019
41	Liver Cirrhosis From Chronic Hypervitaminosis A Resulting in Liver Transplantation: A Case Report. ⁶²	Garcia-Munoz P...Gomez-Bravo MA	30655144	2019
42	Bones in human CYP26B1 deficiency and rats with hypervitaminosis A phenocopy Vegfa overexpression. ⁶²	Lind T...Andersson G	30003121	2018
43	Effects of retinoids on physiologic and inflammatory osteoclastogenesis in vitro. ⁶²	Lionikaite V...Lerner UH	30059166	2018
44	Serum retinyl esters are positively correlated with analyzed total liver vitamin A reserves collected from US adults at time of death. ⁶²	Olsen K...Tanumihardjo SA	30475970	2018
45	Hepatic Vitamin A Concentrations in Vervets (Chlorocebus aethiops) Supplemented with Carotenoids Derived from Oil Palm. ⁶²	Mondloch SJ...van Jaarsveld PJ	30021671	2018
46	Studies of indirect and direct effects of hypervitaminosis A on rat bone by comparing free access to food and pair-feeding. ⁶²	Lind T...Melhus H	29697007	2018
47	Acute fish liver intoxication induced blisters formation and generalized skin peeling. ⁶²	Chang CH...Ho HC	28841060	2018
48	Malaria, Epstein-Barr virus infection and the pathogenesis of Burkitt's lymphoma. ⁶²	Mawson AR...Majumdar S	28707393	2017
49	Identification of potential target genes and related regulatory transcription factors in spontaneous hairline fracture induced by hypervitaminosis A. ⁶²	Peng C...Kong D	28511966	2017
50	IMPACT OF ATRA ON OVALBUMIN AND MOLD-SENSITIZED F344 RATS AND REVERSAL OF HEALTH-RELATED IMPLICATIONS BY CITRAL. ⁶²	Farah IO...Benghuzzi H	29033473	2017

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Genes for Hypervitaminosis a

Genes related to Hypervitaminosis a (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	RBP4	Retinol Binding Protein 4	Protein Coding	14.4	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	1517032
2	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	10.89	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
3	TTR	Transthyretin	Protein Coding	9.64	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	8664978
4	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	7.67	GeneCards inferred via : Publications (show sections)
5	RARS1	Arginyl-TRNA Synthetase 1	Protein Coding	7.13	DISEASES inferred ¹⁴
6	CYP26A1	Cytochrome P450 Family 26 Subfamily A Member 1	Protein Coding	6.66	DISEASES inferred ¹⁴
7	ISX	Intestine Specific Homeobox	Protein Coding	6.66	DISEASES inferred ¹⁴
8	STRA6	Signaling Receptor And Transporter Of Retinol STRA6	Protein Coding	6.64	DISEASES inferred ¹⁴
9	CYP26B1	Cytochrome P450 Family 26 Subfamily B Member 1	Protein Coding	6.46	DISEASES inferred ¹⁴
10	RBP1	Retinol Binding Protein 1	Protein Coding	6.4	DISEASES inferred ¹⁴
11	BCO1	Beta-Carotene Oxygenase 1	Protein Coding	6.2	DISEASES inferred ¹⁴
12	LRAT	Lecithin Retinol Acyltransferase	Protein Coding	6.16	DISEASES inferred ¹⁴
13	CRABP1	Cellular Retinoic Acid Binding Protein 1	Protein Coding	6.08	DISEASES inferred ¹⁴
14	RBP2	Retinol Binding Protein 2	Protein Coding	5.72	DISEASES inferred ¹⁴
15	CRABP2	Cellular Retinoic Acid Binding Protein 2	Protein Coding	5.61	DISEASES inferred ¹⁴

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Variations for Hypervitaminosis a

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Expression for Hypervitaminosis a

Search GEO for disease gene expression data for Hypervitaminosis a.

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Pathways for Hypervitaminosis a

Pathways related to Hypervitaminosis a according to GeneCards Suite gene sharing:

(show all 18)

#	Super pathways	Score	Top Affiliating Genes
1	Disease ⁶⁶ Show member pathways Infectious disease ⁶⁶	13.58	TTR STRA6 RBP4 RBP1 LRAT CYP26B1
2	Metabolism ⁶⁶ Show member pathways Metabolism of lipids ⁶⁶	13.57	BCO1 CYP26A1 CYP26B1 LRAT RARS1 RBP1
3	Olfactory Signaling Pathway ⁶⁶ Show member pathways Expression and translocation of olfactory receptors ⁶⁶ Sensory Perception ⁶⁶	13.17	TTR STRA6 RBP4 RBP2 RBP1 LRAT
4	ESR-mediated signaling ⁶⁶ Show member pathways Estrogen-dependent gene expression ⁶⁶ RUNX1 regulates estrogen receptor mediated transcription ⁶⁶ Signaling by Nuclear Receptors ⁶⁶	12.77	CYP26B1 CYP26A1 CRABP2 CRABP1 CDKN1B
5	Metabolism of water-soluble vitamins and cofactors ⁶⁶ Show member pathways Biotin metabolism, including IMDs ⁷⁴ Biotin transport and metabolism ⁶⁶ Coenzyme A biosynthesis ⁶⁶ Defective BTD causes biotidinase deficiency ⁶⁶ Defective HLCS causes multiple carboxylase deficiency ⁶⁶ Defects in biotin (Btn) metabolism ⁶⁶ Metabolism of cofactors ⁶⁶ Metabolism of folate and pterines ⁶⁶ Metabolism of vitamins and cofactors ⁶⁶ molybdenum cofactor biosynthesis ⁶¹ Molybdenum cofactor biosynthesis ⁶⁶ Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation ⁶⁶ thiamin salvage III ⁶¹ Ubiquinol biosynthesis ⁶⁶ Vitamin B1 (thiamin) metabolism ⁶⁶ Vitamin B2 (riboflavin) metabolism ⁶⁶ Vitamin B5 (pantothenate) metabolism ⁶⁶ Vitamin C (ascorbate) metabolism ⁶⁶ Vitamins B6 activation to pyridoxal phosphate ⁶⁶	12.51	TTR RBP4 RBP2 RBP1 LRAT BCO1
6	Visual phototransduction ⁶⁶ Show member pathways Activation of the phototransduction cascade ⁶⁶ Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) ⁶⁶ Inactivation, recovery and regulation of the phototransduction cascade ⁶⁶ menaquinol-4 biosynthesis II ⁶¹ Metabolism of fat-soluble vitamins ⁶⁶ Metabolism of vitamin K ⁶⁶ Retinoid metabolism and transport ⁶⁶ retinol biosynthesis ⁶¹ The phototransduction cascade ⁶⁶ The retinoid cycle in cones (daylight vision) ⁶⁶ the visual cycle I (vertebrates) ⁶¹ Visual signal transduction: Rods ⁶¹ Vitamin E ⁶⁶	12.24	TTR STRA6 RBP4 RBP2 RBP1 LRAT
7	Adipogenesis ⁷⁴	11.85	CYP26B1 CYP26A1 CDKN1A
8	Retinoblastoma gene in cancer ⁷⁴	11.63	RBP1 CDKN1B CDKN1A
9	Diseases of the neuronal system ⁶⁶ Show member pathways Biosynthesis of A2E, implicated in retinal degradation ⁶⁶ Diseases associated with visual transduction ⁶⁶ Retinoid cycle disease events ⁶⁶ The canonical retinoid cycle in rods (twilight vision) ⁶⁶	11.49	LRAT RBP1 RBP4 STRA6 TTR
10	Signaling by Retinoic Acid ⁶⁶ Show member pathways RA biosynthesis pathway ⁶⁶	11.44	CYP26B1 CYP26A1 CRABP2 CRABP1
11	Regulation of retinoblastoma protein ⁶¹	11.42	RBP2 CDKN1B CDKN1A
12	Visual Cycle in Retinal Rods ⁶⁴	11.41	TTR RBP4 RBP1 LRAT CDKN1B CDKN1A
13	Retinol metabolism (TR) ²² Show member pathways Ifosfamide Pathway, Pharmacokinetics ⁶⁰	11.23	LRAT CRABP1 BCO1
14	Aryl hydrocarbon receptor pathway ⁷⁴	11.05	CDKN1B CDKN1A
15	Vitamin A and carotenoid metabolism ⁷⁴	10.9	RBP4 RBP2 RBP1 LRAT CYP26B1 CYP26A1
16	Retinol metabolism (WikiPathways) ⁷⁴	10.82	LRAT BCO1
17	retinoate biosynthesis I ⁶¹	10.36	RBP4 RBP1
18	retinoate biosynthesis II ⁶¹ Show member pathways Retinoid metabolism disease events ⁶⁶	10.03	RBP4 RBP1

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GO Terms for Hypervitaminosis a

Biological processes related to Hypervitaminosis a according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	heart development	GO:0007507	10.15	STRA6 RBP4 CDKN1B CDKN1A
2	fatty acid transport	GO:0015908	9.97	RBP2 RBP1 CRABP2 CRABP1
3	vitamin A metabolic process	GO:0006776	9.88	LRAT RBP1 RBP2
4	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	GO:0006977	9.87	CDKN1B CDKN1A
5	regulation of cell cycle G1/S phase transition	GO:1902806	9.84	CDKN1B CDKN1A
6	negative regulation of retinoic acid receptor signaling pathway	GO:0048387	9.83	CYP26B1 CYP26A1
7	vitamin metabolic process	GO:0006766	9.81	CYP26A1 CYP26B1
8	retinoic acid biosynthetic process	GO:0002138	9.8	RBP1 CRABP2
9	retinoic acid catabolic process	GO:0034653	9.8	CYP26B1 CYP26A1 CRABP1
10	negative regulation of cyclin-dependent protein kinase activity	GO:1904030	9.78	CDKN1B CDKN1A
11	retinol transport	GO:0034633	9.76	STRA6 RBP4
12	negative regulation of cardiac muscle tissue regeneration	GO:1905179	9.73	CDKN1B CDKN1A
13	retinoic acid metabolic process	GO:0042573	9.73	RBP1 CYP26B1 CYP26A1 CRABP2
14	response to vitamin A	GO:0033189	9.7	CYP26A1 CYP26B1 LRAT RBP1
15	retinol metabolic process	GO:0042572	9.61	TTR RBP4 RBP1 LRAT BCO1
16	regulation of macromolecule metabolic process	GO:0060255	9.56	CDKN1B CDKN1A
17	response to retinoic acid	GO:0032526	9.32	STRA6 RBP4 RBP1 LRAT CYP26B1 CYP26A1

Molecular functions related to Hypervitaminosis a according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	retinoic acid binding	GO:0001972	9.96	CRABP1 CRABP2 CYP26A1 CYP26B1 LRAT
2	fatty acid binding	GO:0005504	9.92	RBP2 RBP1 CRABP2 CRABP1
3	cyclin binding	GO:0030332	9.88	CRABP2 CDKN1B CDKN1A
4	retinoid binding	GO:0005501	9.81	RBP4 RBP2 RBP1 CRABP2 CRABP1
5	lipid binding	GO:0008289	9.8	RBP2 RBP1 CRABP2 CRABP1
6	cyclin-dependent protein serine/threonine kinase inhibitor activity	GO:0004861	9.78	CDKN1B CDKN1A
7	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	GO:0016709	9.76	CYP26B1 CYP26A1
8	retinoic acid 4-hydroxylase activity	GO:0008401	9.73	CYP26B1 CYP26A1
9	retinal binding	GO:0016918	9.73	STRA6 RBP4 RBP2 RBP1 CRABP2 CRABP1
10	retinol transmembrane transporter activity	GO:0034632	9.67	STRA6 RBP4
11	retinol binding	GO:0019841	9.44	STRA6 RBP4 RBP2 RBP1 LRAT CRABP2

Sources

Sources for Hypervitaminosis a

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

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MCID: HYP058 MIFTS: 48	Hypervitaminosis a Categories: Endocrine diseases, Liver diseases, Metabolic diseases	Data Licensing For inquiries, contact: [email protected]
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