Hypervitaminosis a disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HYP058 MIFTS: 49	Hypervitaminosis a Categories: Metabolic diseases
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Aliases & Classifications for Hypervitaminosis a

MalaCards integrated aliases for Hypervitaminosis a:

Name: Hypervitaminosis a ⁵⁶ ¹² ⁷⁴ ⁵⁴ ⁴³ ¹⁵ ¹⁷ ⁷¹ ³²

Hypervitaminosis a, Susceptibility to ⁵⁶

Characteristics:

OMIM:

⁵⁶

Inheritance:
autosomal recessive

HPO:

³¹

hypervitaminosis a:
Inheritance autosomal recessive inheritance

Classifications:

MalaCards categories:
Global: Metabolic diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Endocrine, nutritional and metabolic diseases

Obesity and other hyperalimentation

Other hyperalimentation

Hypervitaminosis A

External Ids:

Disease Ontology ¹² DOID:9972

OMIM ⁵⁶ 240150

ICD9CM ³⁴ 278.2

MeSH ⁴³ D006986

SNOMED-CT ⁶⁷ 64559002

ICD10 ³² E67.0

MedGen ⁴¹ C1855883

SNOMED-CT via HPO ⁶⁸ 10601006 166702002 19754005 more

EFO ¹⁷ EFO_1000978

UMLS ⁷¹ C0020579

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Summaries for Hypervitaminosis a

Disease Ontology : ¹² An overnutrition that is characterized by excess vitamin A, has symptom hepatomegaly, anorexia, fever, alopecia, and arthralgia, and has material basis in excessive intake of vitaimin A, and/or derangement of vitamin A metabolism.

MalaCards based summary : Hypervitaminosis a, also known as hypervitaminosis a, susceptibility to, is related to keratomalacia and hypercarotenemia and vitamin a deficiency, autosomal dominant, and has symptoms including hepatomegaly An important gene associated with Hypervitaminosis a is RBP4 (Retinol Binding Protein 4), and among its related pathways/superpathways are Signaling by GPCR and Metabolism of water-soluble vitamins and cofactors. The drugs Vitamin A and Trace Elements have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and skin, and related phenotypes are increased intracranial pressure and renal insufficiency

Wikipedia : ⁷⁴ Hypervitaminosis A refers to the toxic effects of ingesting too much preformed vitamin A. Symptoms arise... more...

More information from OMIM: 240150

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Related Diseases for Hypervitaminosis a

Diseases in the Hypervitaminosis a family:

Hypervitaminosis D

Diseases related to Hypervitaminosis a via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)

#	Related Disease	Score	Top Affiliating Genes
1	keratomalacia	30.1	RBP4 CYP26A1
2	hypercarotenemia and vitamin a deficiency, autosomal dominant	29.3	TTR RBP4 RARS1 CYP26A1 BCO1
3	cleft palate, isolated	10.3
4	intracranial hypertension	10.3
5	neurofibromatosis, type ii	10.2
6	hyperostosis	10.2
7	hydrocephalus	10.2
8	intracranial hypertension, idiopathic	10.2
9	kidney disease	10.1
10	exencephaly	10.1
11	papilledema	10.1
12	caffey disease	10.0
13	fibrosis of extraocular muscles, congenital, 1	10.0
14	cystic fibrosis	10.0
15	portal hypertension	10.0
16	hard palate cancer	10.0
17	fatty liver disease	10.0
18	spondylosis, cervical	9.9
19	anencephaly	9.9
20	bone resorption disease	9.9
21	hydronephrosis	9.9
22	hyperparathyroidism	9.9
23	spondylosis	9.9
24	ankylosis	9.9
25	acute kidney failure	9.9
26	liver cirrhosis	9.9
27	neuroblastoma	9.9
28	chronic kidney disease	9.9
29	alopecia	9.9
30	hypervitaminosis d	9.9
31	atherosclerosis susceptibility	9.8
32	gastroesophageal reflux	9.8
33	alagille syndrome 1	9.8
34	migraine with or without aura 1	9.8
35	osteoporosis	9.8
36	neural tube defects	9.8
37	varicose veins	9.8
38	autism	9.8
39	hypoascorbemia	9.8
40	ocular motor apraxia	9.8
41	fryns microphthalmia syndrome	9.8
42	homocysteinemia	9.8
43	bulimia nervosa	9.8
44	malaria	9.8
45	bone mineral density quantitative trait locus 8	9.8
46	bone mineral density quantitative trait locus 15	9.8
47	retinal dystrophy, iris coloboma, and comedogenic acne syndrome	9.8
48	hydrops, lactic acidosis, and sideroblastic anemia	9.8
49	deficiency anemia	9.8
50	hyperphosphatemia	9.8

Graphical network of the top 20 diseases related to Hypervitaminosis a:

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Symptoms & Phenotypes for Hypervitaminosis a

Human phenotypes related to Hypervitaminosis a:

³¹ (show all 10)

#	Description	HPO Source Accession
1	increased intracranial pressure ³¹	HP:0002516
2	renal insufficiency ³¹	HP:0000083
3	ascites ³¹	HP:0001541
4	hypercalcemia ³¹	HP:0003072
5	papilledema ³¹	HP:0001085
6	abnormality of the liver ³¹	HP:0001392
7	lower limb pain ³¹	HP:0012514
8	nausea ³¹	HP:0002018
9	abnormality of the coagulation cascade ³¹	HP:0003256
10	alopecia totalis ³¹	HP:0007418

Symptoms via clinical synopsis from OMIM:

⁵⁶

H E E N T:
increased intracranial pressure
papilledema
splayed cranial sutures

Lab:
hypercalcemia

G U:
renal failure

Heme:
coagulopathy

G I:
ascites
nausea
liver disease

Skin:
alopecia totalis
erythematous, exfoliative rash

Skel:
leg pain
periosteal new bone formation

Clinical features from OMIM:

240150

Symptoms:

¹²

• hepatomegaly

MGI Mouse Phenotypes related to Hypervitaminosis a:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.08	CDKN1A CDKN1B CYP26A1 CYP26B1 RARG RBP4
2	homeostasis/metabolism	MP:0005376	10.07	BCO1 CDKN1A CDKN1B CYP26B1 RARG RBP1
3	digestive/alimentary	MP:0005381	9.98	CDKN1A CDKN1B CYP26A1 RARG RBP2 RBP4
4	craniofacial	MP:0005382	9.93	CDKN1A CDKN1B CYP26A1 CYP26B1 RARG STRA6
5	hearing/vestibular/ear	MP:0005377	9.88	CDKN1A CDKN1B CRABP1 CRABP2 RARG RBP1
6	limbs/digits/tail	MP:0005371	9.8	CDKN1A CRABP1 CRABP2 CYP26A1 CYP26B1 RBP4
7	no phenotypic analysis	MP:0003012	9.73	CDKN1A CDKN1B CYP26A1 ISX STRA6 TTR
8	renal/urinary system	MP:0005367	9.63	CDKN1A CDKN1B CYP26A1 RARG RBP4 TTR
9	reproductive system	MP:0005389	9.56	CDKN1A CDKN1B CRABP1 CYP26A1 CYP26B1 RARG
10	vision/eye	MP:0005391	9.23	CDKN1A CDKN1B CYP26B1 RARG RBP1 RBP4

Sources

Drugs & Therapeutics for Hypervitaminosis a

Drugs for Hypervitaminosis a (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Vitamin A

Approved, Nutraceutical, Vet_approved

22737-96-8, 11103-57-4, 68-26-8

9904001 445354

Synonyms:

(11-cis,13-cis)-Retinol acetate

(13cis)-Retinol

(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol

(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-ol

(2Z,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol

(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol

.alpha.lin

.alpha.sterol

.beta.-Retinol

[11,12-3H]-Retinol

11,13-Di-cis-vitamin a acetate

11103-57-4

11-cis-13-cis-Retinol acetate

11-cis-13-cis-Retinyl acetate

13123-33-6

1341-18-0

1406-67-3

17104-91-5

1rbp

3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclchexen-1-yl)-2,4,6,8-nonatetraen-1-ol

3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol

3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonate-traen-1-ol

3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol, (all-E)-Isomer

3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-2,4,6,8-nonatetraen-1-ol

4-06-00-04133 (Beilstein Handbook Reference)

53637-36-8

5979-23-7

68-26-8

95144_FLUKA

95144_SIGMA

95146_FLUKA

95146_SIGMA

AC-11701

AC1L9HU3

AC1Q7BU9

ACON

Afaxin

Agiolan

Agoncal

Alcohol 9,13-dimethyl-7-(1,1,5-trimethyl-6-cyclohexen-5-yl)-7,9,11,13-nonatetraen-15-ol

Alcovit A

alin

All Trans Retinol

All-trans retinol

ALL-TRANS RETINOL (SEE ALSO RETINOID PROJECT 1)

all-trans-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol

all-trans-retinol

all-trans-Retinol

all-trans-retinyl alcohol

all-trans-Retinyl alcohol

all-trans-Vitamin A

all-trans-vitamin A alcohol

all-trans-Vitamin A alcohol

all-trans-Vitamin A1

Alphalin

Alphasterol

A-Mulsal

Anatola

Anatola A

Anti-infective vitamin

Antixerophthalmic vitamin

Antixerophthalmisches Vitamin

Aoral

Apexol

Apostavit

Aquasol A Parenteral

Aquasynth

AR-1L3057

A-Sol

Atars

ATAV

Avibon

A-Vi-Pel

Avita

A-Vitan

Avitol

Axerol

Axerophthol

Axerophtholum

Bentavit A

beta-Retinol

BIDD:PXR0102

Biosterol

BRN 0403040

C00473

C17276

C20H30O

CCRIS 5444

CHEBI:17336

CHEMBL986

Chocola A

CID445354

Cylasphere

D014801

D06543

DB00162

Del-VI-A

Disatabs Tabs

Dofsol

Dohyfral A

EINECS 200-683-7

EINECS 234-328-2

Epiteliol

Hi-A-Vita

HMS1921B04

HMS2092L13

HMS501I08

Homagenets Aoral

Homagenets aorl

HSDB 815

Hydrovit A

IDI1_000486

Lard Factor

LMPR01090001

LPK

LS-1578

M.V.C. 9+3

M.V.I.-12

MLS001066379

MLS001074751

MolPort-001-785-962

Mvc Plus

Myvpack

NCGC00091784-01

NCGC00091784-02

NCGC00091784-03

NCGC00091784-04

NCGC00091784-05

NCGC00091784-06

Nio-A-Let

NSC 122759

NSC122759

Oleovitamin A

Ophthalamin

Plivit A

Prepalin

R7632_SIGMA

Retin-11,12-t2-ol (9CI)

retinol

Retinol

RETINOL

Retinol [INN:BAN]

Retinol solution

Retinol-(cellular-retinol-binding-protein)

Retinol, all-trans- (8CI)

Retinolo

Retinolo [DCIT]

Retinolum

Retinolum [INN-Latin]

Retrovitamin A

Ro-a-vit

Rovimix A 500

SDCCGMLS-0066724.P001

Sehkraft A

SMP2_000102

SMR000112036

Solu-A

SPECTRUM1501203

Spectrum5_000993

Spectrum5_001997

ST057232

Super A

Testavol

Testavol S

Thalasphere

trans-retinol

trans-Retinol acid (Vitamin A)

trans-Vitamin A alcohol

tROL

UNII-81G40H8B0T

UNII-G2SH0XKK91

Vaflol

Vafol

Veroftal

Vi-.alpha.

Vi-a

Vi-Alpha

Vi-Dom-A

Vio-A

Vitamin A

Vitamin- A

Vitamin A (Feed)

Vitamin A (USP)

Vitamin A alcohol

Vitamin- A alcohol

Vitamin A alcohol (VAN)

Vitamin- A alcohol solution

Vitamin A cryst

Vitamin A1

Vitamin- A1

Vitamin A1 alcohol

Vitamin A1 alcohol, all trans

Vitamin-?A

Vitamin-?A alcohol

Vitamin-?A alcohol solution

Vitamin-?A1

Vitamine A

Vitaminum A

Vitavel A

Vitavel-A

Vitpex

Vogan

Vogan-Neu

Vogan-nu

Wachstumsvitamin

WLN: L6UTJ A1 B1U1Y1&U2U1Y1&U2Q C1 C1

ZINC03831417

Zinosan N

Trace Elements

Liver Extracts

Retinol palmitate

Micronutrients

Vitamins

Nutrients

Protective Agents

retinol

Antioxidants

Interventional clinical trials:

#	Name	Status	NCT ID	Drugs
1	Total Body Vitamin A Pool Size in Preschool Children Before and After Vitamin A Supplementation in an Impoverished South African Community Where Liver is Frequently Eaten and Children Exposed to Vitamin A Fortified Staple Foods	Completed	NCT02915731
2	Vitamin A Liver Reserves and Serum Markers of Vitamin A in US Adults at Time of Death	Completed	NCT03305042
3	High/Low Dose Vit A in Diarrhea/ALRI in Severe PEM	Completed	NCT00388921	Vitamin A

Search NIH Clinical Center for Hypervitaminosis a

Cochrane evidence based reviews: hypervitaminosis a

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Genetic Tests for Hypervitaminosis a

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Anatomical Context for Hypervitaminosis a

MalaCards organs/tissues related to Hypervitaminosis a:

⁴⁰

Bone, Liver, Skin, Testes, Lung, Thyroid, Eye

Sources

Publications for Hypervitaminosis a

Articles related to Hypervitaminosis a:

(show top 50) (show all 735)

#	Title	Authors	PMID	Year
1	Severe hypervitaminosis A in siblings: evidence of variable tolerance to retinol intake. ⁵⁶ ⁶¹	Carpenter TO...Anast CS	3655980	1987
2	Unusual presentation of vitamin A intoxication. ⁵⁶	Schurr D...Abrahamov A	6644452	1983
3	Analysis of normal and truncated holo- and apo-retinol-binding protein (RBP) in human serum: altered ratios in chronic renal failure. ⁶¹ ⁵⁴	Jaconi S...Siegenthaler G	8664978	1996
4	Serum levels of vitamin A and retinol binding protein in chronic renal patients treated by continuous ambulatorial peritoneal dialysis. ⁶¹ ⁵⁴	Vannucchi MT...Humphreys M	1517032	1992
5	Vitamin A administration in lizards during tail regeneration determines epithelial mucogenesis and delays muscle and cartilage differentiation. ⁶¹	Alibardi L	31631512	2020
6	Rubella Virus Infection, the Congenital Rubella Syndrome, and the Link to Autism. ⁶¹	Mawson AR...Croft AM	31546693	2019
7	South African preschool children habitually consuming sheep liver and exposed to vitamin A supplementation and fortification have hypervitaminotic A liver stores: a cohort study. ⁶¹	van Stuijvenberg ME...Tanumihardjo SA	31089689	2019
8	Restricting vitamin A intake increases bone formation in Zambian children with high liver stores of vitamin. ⁶¹	Tanumihardjo SA...Binkley NC	31254130	2019
9	Overlapping vitamin A interventions in the United States, Guatemala, Zambia, and South Africa: case studies. ⁶¹	Tanumihardjo SA...van Stuijvenberg ME	30265402	2019
10	Correction osteotomy for bilateral varus knee deformity caused by premature epiphyseal closure induced by hypervitaminosis A: a case report. ⁶¹	Matsuoka M...Iwasaki N	31202274	2019
11	Highlight Article: Retinol isotope dilution accurately predicts liver reserves in piglets but overestimates reserves in lactating sows. ⁶¹	Sheftel J...Tanumihardjo SA	30889962	2019
12	Vitamin A decreases the anabolic bone response to mechanical loading by suppressing bone formation. ⁶¹	Lionikaite V...Lerner UH	30668919	2019
13	Gulf War Illness: Unifying Hypothesis for a Continuing Health Problem. ⁶¹	Mawson AR...Croft AM	30609834	2019
14	The Need to Consider Context in the Evaluation of Anti-infectious and Immunomodulatory Effects of Vitamin A and its Derivatives. ⁶¹	Xavier-Elsas P...Gaspar-Elsas MIC	30556501	2019
15	Spectrum of Voriconazole-Induced Periostitis With Review of the Differential Diagnosis. ⁶¹	Tan I...Mar WA	30403528	2019
16	Liver Cirrhosis From Chronic Hypervitaminosis A Resulting in Liver Transplantation: A Case Report. ⁶¹	Garcia-Munoz P...Gomez-Bravo MA	30655144	2019
17	Acute hypervitaminosis A misdiagnosed as malaria in a 7-year-old Nigerian boy. ⁶¹	Babatola AO...Alfred A	31372061	2019
18	Bones in human CYP26B1 deficiency and rats with hypervitaminosis A phenocopy Vegfa overexpression. ⁶¹	Lind T...Andersson G	30003121	2018
19	Effects of retinoids on physiologic and inflammatory osteoclastogenesis in vitro. ⁶¹	Lionikaite V...Lerner UH	30059166	2018
20	Serum retinyl esters are positively correlated with analyzed total liver vitamin A reserves collected from US adults at time of death. ⁶¹	Olsen K...Tanumihardjo SA	30475970	2018
21	Hepatic Vitamin A Concentrations in Vervets (Chlorocebus aethiops) Supplemented with Carotenoids Derived from Oil Palm. ⁶¹	Mondloch SJ...van Jaarsveld PJ	30021671	2018
22	Studies of indirect and direct effects of hypervitaminosis A on rat bone by comparing free access to food and pair-feeding. ⁶¹	Lind T...Melhus H	29697007	2018
23	Acute fish liver intoxication induced blisters formation and generalized skin peeling. ⁶¹	Chang CH...Ho HC	28841060	2018
24	Malaria, Epstein-Barr virus infection and the pathogenesis of Burkitt's lymphoma. ⁶¹	Mawson AR...Majumdar S	28707393	2017
25	Identification of potential target genes and related regulatory transcription factors in spontaneous hairline fracture induced by hypervitaminosis A. ⁶¹	Peng C...Kong D	28511966	2017
26	Vitamin A in pediatrics: An update from the Nutrition Committee of the French Society of Pediatrics. ⁶¹	Vidailhet M...Briend A	28139365	2017
27	IMPACT OF ATRA ON OVALBUMIN AND MOLD-SENSITIZED F344 RATS AND REVERSAL OF HEALTH-RELATED IMPLICATIONS BY CITRAL. ⁶¹	Farah IO...Benghuzzi H	29033473	2017
28	Excessive dietary intake of vitamin A reduces skull bone thickness in mice. ⁶¹	Lind T...Melhus H	28426756	2017
29	Hypertrophic Osteoarthropathy: Clinical and Imaging Features. ⁶¹	Yap FY...Matcuk GR	27935768	2017
30	A baby with a lot of nerve. ⁶¹	Ramkumar HL...Liu GT	26656927	2016
31	Assessing the Safety of Vitamin A Delivered Through Large-Scale Intervention Programs: Workshop Report on Setting the Research Agenda. ⁶¹	Tanumihardjo SA...Brown KH	26893060	2016
32	Immediate effects of retinoic acid on gene expression in primary murine osteoblasts. ⁶¹	Yorgan TA...Schinke T	25956707	2016
33	Characterization of hypertrophic osteoarthropathy in an identified skeleton from Évora, Portugal, using combined and comparative morphology and microscopy. ⁶¹	Anselmo D...Fernandes T	29539516	2016
34	Persistent behavioral effects following early life exposure to retinoic acid or valproic acid in zebrafish. ⁶¹	Bailey JM...Levin ED	26439099	2016
35	Pathogenesis of Zika Virus-Associated Embryopathy. ⁶¹	Mawson AR	27403405	2016
36	[MALABSORPTION FAT-SOLUBLE VITAMINS AND PROSPECTS OF THEIR USE IN LIVER DISEASES]. ⁶¹	Khavkin AI...Komarova ON	30284430	2016
37	Association of dietary consumption and serum levels of vitamin A and β-carotene with bone mineral density in Chinese adults. ⁶¹	Chen GD...Chen YM	26027509	2015
38	High provitamin A carotenoid serum concentrations, elevated retinyl esters, and saturated retinol-binding protein in Zambian preschool children are consistent with the presence of high liver vitamin A stores. ⁶¹	Mondloch S...Tanumihardjo SA	26178727	2015
39	Comparisons among Equations Used for Retinol Isotope Dilution in the Assessment of Total Body Stores and Total Liver Reserves. ⁶¹	Gannon BM...Tanumihardjo SA	25809683	2015
40	[Idiopathic intracranial hypertension caused by dietary hypervitaminosis A]. ⁶¹	Aispuru GR...Pascual-Pablo EE	25088054	2015
41	Hypervitaminosis A is prevalent in children with CKD and contributes to hypercalcemia. ⁶¹	Manickavasagar B...Shroff R	25119682	2015
42	Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN): could retinoids play a causative role? ⁶¹	Mawson AR...Karre S	25579087	2015
43	Retinoid receptors in bone and their role in bone remodeling. ⁶¹	Henning P...Lerner UH	25814978	2015
44	Biofortified orange maize is as efficacious as a vitamin A supplement in Zambian children even in the presence of high liver reserves of vitamin A: a community-based, randomized placebo-controlled trial. ⁶¹	Gannon B...Tanumihardjo SA	25411289	2014
45	Hypervitaminosis A causing hypercalcemia in cystic fibrosis. Case report and focused review. ⁶¹	Safi KH...Nasr SZ	25188737	2014
46	Clinical associations of hepatic stellate cell (HSC) hyperplasia. ⁶¹	Mounajjed T...Smyrk TC	24809674	2014
47	Hypervitaminosis A-induced hepatic fibrosis in a cat. ⁶¹	Guerra JM...Cogliati B	24563496	2014
48	Hypercalcaemia secondary to hypervitaminosis a in a patient with chronic renal failure. ⁶¹	Hammoud D...Abdallah J	25303202	2014
49	Pediatric idiopathic intracranial hypertension and the underlying endocrine-metabolic dysfunction: a pilot study. ⁶¹	Salpietro V...Ruggieri M	24025722	2014
50	Mefloquine use, psychosis, and violence: a retinoid toxicity hypothesis. ⁶¹	Mawson A	23852388	2013

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Genes for Hypervitaminosis a

Genes related to Hypervitaminosis a (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	RBP4	Retinol Binding Protein 4	Protein Coding	14.54	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	1517032
2	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	10.33	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	TTR	Transthyretin	Protein Coding	9.84	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	8664978
4	RARS1	Arginyl-TRNA Synthetase 1	Protein Coding	6.92	DISEASES inferred ¹⁵
5	CYP26A1	Cytochrome P450 Family 26 Subfamily A Member 1	Protein Coding	6.77	DISEASES inferred ¹⁵
6	CYP26B1	Cytochrome P450 Family 26 Subfamily B Member 1	Protein Coding	6.74	DISEASES inferred ¹⁵
7	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	6.69	GeneCards inferred via : Publications (show sections)
8	STRA6	Signaling Receptor And Transporter Of Retinol STRA6	Protein Coding	6.56	DISEASES inferred ¹⁵
9	RBP1	Retinol Binding Protein 1	Protein Coding	6.56	DISEASES inferred ¹⁵
10	ISX	Intestine Specific Homeobox	Protein Coding	6.31	DISEASES inferred ¹⁵
11	CRABP1	Cellular Retinoic Acid Binding Protein 1	Protein Coding	5.9	DISEASES inferred ¹⁵
12	CRABP2	Cellular Retinoic Acid Binding Protein 2	Protein Coding	5.88	DISEASES inferred ¹⁵
13	BCO1	Beta-Carotene Oxygenase 1	Protein Coding	5.87	DISEASES inferred ¹⁵
14	RARG	Retinoic Acid Receptor Gamma	Protein Coding	5.74	DISEASES inferred ¹⁵
15	RBP2	Retinol Binding Protein 2	Protein Coding	5.68	DISEASES inferred ¹⁵

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Variations for Hypervitaminosis a

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Expression for Hypervitaminosis a

Search GEO for disease gene expression data for Hypervitaminosis a.

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Pathways for Hypervitaminosis a

Pathways related to Hypervitaminosis a according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	Signaling by GPCR ⁶⁵ Show member pathways GPCR downstream signaling ⁶⁵ Signal Transduction ⁶⁵	13.91	TTR STRA6 RBP4 RBP2 RBP1 RARG
2	Metabolism of water-soluble vitamins and cofactors ⁶⁵ Show member pathways [2Fe-2S] iron-sulfur cluster biosynthesis ¹ Biotin transport and metabolism ⁶⁵ biotin-carboxyl carrier protein assembly ¹ coenzyme A biosynthesis ¹ Coenzyme A biosynthesis ⁶⁵ flavin biosynthesis ¹ folate polyglutamylation ¹ glycine/serine biosynthesis ¹ Metabolism of folate and pterines ⁶⁵ Metabolism of vitamins and cofactors ⁶⁵ molybdenum cofactor biosynthesis ¹ Molybdenum cofactor biosynthesis ⁶⁵ thiamin salvage III ¹ thio-molybdenum cofactor biosynthesis ¹ Vitamin B1 (thiamin) metabolism ⁶⁵ Vitamin B2 (riboflavin) metabolism ⁶⁵ Vitamin B5 (pantothenate) metabolism ⁶⁵ Vitamin C (ascorbate) metabolism ⁶⁵ Vitamins B6 activation to pyridoxal phosphate ⁶⁵	12.44	TTR RBP4 RBP2 RBP1 BCO1
3	Metabolism of fat-soluble vitamins ⁶⁵ Show member pathways Metabolism of vitamin K ⁶⁵ Retinoid metabolism and transport ⁶⁵ The retinoid cycle in cones (daylight vision) ⁶⁵ Visual phototransduction ⁶⁵ Vitamin D (calciferol) metabolism ⁶⁵	12.13	TTR STRA6 RBP4 RBP2 RBP1 BCO1
4	Adipogenesis ¹	11.81	CYP26B1 CYP26A1 CDKN1A
5	Visual Cycle in Retinal Rods ⁶³	11.74	TTR RBP4 RBP1 CDKN1B CDKN1A
6	Retinoblastoma (RB) in Cancer ¹	11.6	RBP1 CDKN1B CDKN1A
7	Regulation of retinoblastoma protein ¹	11.38	RBP2 CDKN1B CDKN1A
8	Signaling by Retinoic Acid ⁶⁵ Show member pathways RA biosynthesis pathway ⁶⁵	11.37	RARG CYP26B1 CYP26A1 CRABP2 CRABP1
9	the visual cycle I (vertebrates) ¹ Show member pathways retinol biosynthesis ¹ The canonical retinoid cycle in rods (twilight vision) ⁶⁵	11.09	TTR STRA6 RBP4 RBP2 RBP1
10	Vitamin A and Carotenoid Metabolism ¹	10.92	RBP4 RBP2 RBP1 RARG CYP26B1 CYP26A1
11	Diseases associated with visual transduction ⁶⁵ Show member pathways Biosynthesis of A2E, implicated in retinal degradation ⁶⁵ Retinoid cycle disease events ⁶⁵	10.84	TTR STRA6 RBP4 RBP1
12	retinoate biosynthesis II ¹ Show member pathways retinoate biosynthesis I ¹ Retinoid metabolism disease events ⁶⁵	10.61	RBP4 RBP1

Sources

GO Terms for Hypervitaminosis a

Cellular components related to Hypervitaminosis a according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein-containing complex	GO:0032991	9.02	TTR STRA6 RBP4 CDKN1B CDKN1A

Biological processes related to Hypervitaminosis a according to GeneCards Suite gene sharing:

(show all 23)

#	Name	GO ID	Score	Top Affiliating Genes
1	heart development	GO:0007507	9.85	STRA6 RBP4 CDKN1B CDKN1A
2	kidney development	GO:0001822	9.75	STRA6 CYP26B1 CYP26A1
3	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO:0045736	9.61	CDKN1B CDKN1A
4	sterol metabolic process	GO:0016125	9.61	CYP26B1 CYP26A1
5	mitotic cell cycle arrest	GO:0071850	9.6	CDKN1B CDKN1A
6	retinoic acid receptor signaling pathway	GO:0048384	9.59	RARG CYP26B1
7	negative regulation of phosphorylation	GO:0042326	9.58	CDKN1B CDKN1A
8	positive regulation of programmed cell death	GO:0043068	9.57	RARG CDKN1A
9	negative regulation of retinoic acid receptor signaling pathway	GO:0048387	9.56	CYP26B1 CYP26A1
10	response to retinoic acid	GO:0032526	9.56	RBP4 RARG CYP26B1 CYP26A1
11	vitamin metabolic process	GO:0006766	9.54	CYP26B1 CYP26A1
12	retinoic acid metabolic process	GO:0042573	9.54	RBP1 CYP26A1 CRABP2
13	vitamin A metabolic process	GO:0006776	9.52	RBP2 RBP1
14	regulation of retinoic acid receptor signaling pathway	GO:0048385	9.51	CYP26B1 CRABP2
15	response to vitamin A	GO:0033189	9.5	RBP1 CYP26B1 CYP26A1
16	ergosterol biosynthetic process	GO:0006696	9.49	CYP26B1 CYP26A1
17	retinoic acid biosynthetic process	GO:0002138	9.48	RBP1 CRABP2
18	negative regulation of cyclin-dependent protein kinase activity	GO:1904030	9.46	CDKN1B CDKN1A
19	retinol metabolic process	GO:0042572	9.46	TTR RBP4 RBP1 BCO1
20	negative regulation of cardiac muscle tissue regeneration	GO:1905179	9.43	CDKN1B CDKN1A
21	retinol transport	GO:0034633	9.4	STRA6 RBP4
22	retinoic acid catabolic process	GO:0034653	9.13	CYP26B1 CYP26A1 CRABP1
23	retinoid metabolic process	GO:0001523	9.1	TTR STRA6 RBP4 RBP2 RBP1 BCO1

Molecular functions related to Hypervitaminosis a according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	lipid binding	GO:0008289	9.78	RBP2 RBP1 CRABP2 CRABP1
2	retinoic acid binding	GO:0001972	9.56	CYP26B1 CYP26A1 CRABP2 CRABP1
3	retinoid binding	GO:0005501	9.55	RBP4 RBP2 RBP1 CRABP2 CRABP1
4	cyclin binding	GO:0030332	9.51	CDKN1B CDKN1A
5	protein kinase inhibitor activity	GO:0004860	9.49	CDKN1B CDKN1A
6	cyclin-dependent protein serine/threonine kinase inhibitor activity	GO:0004861	9.46	CDKN1B CDKN1A
7	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	GO:0016709	9.43	CYP26B1 CYP26A1
8	retinol binding	GO:0019841	9.43	STRA6 RBP4 RBP2 RBP1 CRABP2 CRABP1
9	retinoic acid 4-hydroxylase activity	GO:0008401	9.4	CYP26B1 CYP26A1
10	C-22 sterol desaturase activity	GO:0000249	9.37	CYP26B1 CYP26A1
11	retinol transmembrane transporter activity	GO:0034632	9.32	STRA6 RBP4
12	retinal binding	GO:0016918	9.1	STRA6 RBP4 RBP2 RBP1 CRABP2 CRABP1

Sources

Sources for Hypervitaminosis a

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