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MCID: HYP057
MIFTS: 41

Hypervitaminosis D

Categories: Metabolic diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Hypervitaminosis D

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MalaCards integrated aliases for Hypervitaminosis D:

Name: Hypervitaminosis D 12 76 15 73

Classifications:

MalaCards categories:
Global: Metabolic diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:9971
ICD10 33 E67.3
ICD9CM 35 278.4
SNOMED-CT 68 190969000 27712000
UMLS 73 C1442839
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Summaries for Hypervitaminosis D

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MalaCards based summary : Hypervitaminosis D is related to arterial calcification of infancy and calcinosis. An important gene associated with Hypervitaminosis D is PTH (Parathyroid Hormone), and among its related pathways/superpathways are Negative regulation of FGFR3 signaling and Signaling by FGFR2. The drugs Vitamin D and Vitamin D3 have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and placenta, and related phenotypes are cardiovascular system and cellular

Wikipedia : 76 Hypervitaminosis D is a state of vitamin D toxicity. The normal range for blood concentration is 30.0 to... more...

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Related Diseases for Hypervitaminosis D

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Diseases in the Hypervitaminosis a family:

Hypervitaminosis D

Diseases related to Hypervitaminosis D via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 arterial calcification of infancy 31.5 FGF23 GALNT3
2 calcinosis 29.1 FGF23 GALNT3 KL
3 rickets 28.0 CYP27B1 FGF23 PTH VDR
4 hyperparathyroidism 27.8 CYP27B1 FGF23 PTH VDR
5 osteoporosis 26.9 CYP27B1 FGF23 KL PTH VDR
6 oncogenic osteomalacia 10.2 FGF23 PTH
7 hypercalcemia, infantile, 1 10.2 PTH VDR
8 impaired renal function disease 10.2 FGF23 PTH
9 pulmonary alveolar microlithiasis 10.2 FGF23 PTH
10 tracheal calcification 10.2 FGF23 KL
11 metaphyseal chondrodysplasia, jansen type 10.2 FGF23 PTH
12 idiopathic hypercalciuria 10.1 TRPV5 VDR
13 bone resorption disease 10.1 PTH VDR
14 hypophosphatemia 10.0 FGF23 PTH
15 hypophosphatemic rickets, autosomal dominant 9.9 FGF23 GALNT3
16 diabetes insipidus, nephrogenic, autosomal 9.9
17 arteriosclerosis 9.9
18 diabetes insipidus 9.9
19 parathyroid adenoma 9.9 PTH VDR
20 osteomalacia 9.8 FGF23 VDR
21 lacrimoauriculodentodigital syndrome 9.8 FGF23 GALNT3
22 spondylosis 9.8 KL PTH VDR
23 hypoparathyroidism 9.8 FGF23 PTH
24 alagille syndrome 1 9.8
25 rheumatoid arthritis 9.8
26 cystic fibrosis 9.8
27 hypervitaminosis a 9.8
28 intracranial hypertension, idiopathic 9.8
29 aging 9.8
30 arthritis 9.8
31 dentin dysplasia 9.8
32 mannosidosis 9.8
33 fanconi syndrome 9.8
34 pneumocystosis 9.8
35 pulmonary tuberculosis 9.8
36 pneumonia 9.8
37 periodontitis 9.8
38 depression 9.8
39 urinary system disease 9.7 FGF23 KL PTH
40 vitamin d-dependent rickets, type 2a 9.7 CYP27B1 VDR
41 calciphylaxis 9.7 FGF23 PTH VDR
42 parathyroid gland disease 9.7 FGF23 PTH VDR
43 renal osteodystrophy 9.7 FGF23 PTH VDR
44 primary hyperparathyroidism 9.7 FGF23 PTH VDR
45 bone disease 9.6 FGF23 PTH VDR
46 tumoral calcinosis, hyperphosphatemic, familial, 1 9.5 FGF23 GALNT3 KL
47 uremia 9.5 PTH VDR
48 familial tumoral calcinosis 9.5 FGF23 GALNT3 KL
49 kidney disease 9.5 FGF23 PTH VDR
50 hyperostosis 9.5 FGF23 GALNT3 KL

Graphical network of the top 20 diseases related to Hypervitaminosis D:



Diseases related to Hypervitaminosis D
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Symptoms & Phenotypes for Hypervitaminosis D

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MGI Mouse Phenotypes related to Hypervitaminosis D:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.01 VDR PTH CYP27B1 KL FGF23 GALNT3
2 cellular MP:0005384 10 TRPV5 VDR PTH GALNT3 CYP27B1 KL
3 growth/size/body region MP:0005378 10 VDR PTH TRPV5 KL FGF23 GALNT3
4 hematopoietic system MP:0005397 9.98 VDR TRPV5 KL FGF23 PTH GALNT3
5 endocrine/exocrine gland MP:0005379 9.95 VDR PTH KL FGF23 GALNT3 CYP27B1
6 homeostasis/metabolism MP:0005376 9.95 VDR PTH TRPV5 CYP27B1 KL FGF23
7 craniofacial MP:0005382 9.91 VDR PTH KL GALNT3 CYP27B1
8 immune system MP:0005387 9.91 VDR PTH TRPV5 KL FGF23 GALNT3
9 digestive/alimentary MP:0005381 9.89 VDR TRPV5 KL FGF23 GALNT3
10 limbs/digits/tail MP:0005371 9.73 VDR KL FGF23 PTH GALNT3 CYP27B1
11 integument MP:0010771 9.72 VDR CYP27B1 KL FGF23 GALNT3
12 renal/urinary system MP:0005367 9.63 VDR TRPV5 KL FGF23 GALNT3 CYP27B1
13 reproductive system MP:0005389 9.35 VDR GALNT3 CYP27B1 KL FGF23
14 skeleton MP:0005390 9.17 VDR TRPV5 KL FGF23 PTH GALNT3
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Drugs & Therapeutics for Hypervitaminosis D

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Drugs for Hypervitaminosis D (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1406-16-2
2
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 67-97-0 6221 5280795
3
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-14-6 5280793
4 Calcifediol Phase 4 19356-17-3
5 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
6 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
7 Hydroxycholecalciferols Phase 4
8 Ergocalciferols Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
9 Vitamins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
10 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11 Vitamin D2 Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12 Calciferol Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
13 Hepcidins Phase 2
14 Pharmaceutical Solutions Phase 2,Not Applicable
15 Anti-Infective Agents Phase 2
16 Calcium, Dietary Not Applicable
17 Olive Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effect of Supplementation With Two Different Doses of Vitamin D on Bone Mineral Density, Vitamin D Levels and Hand Grip Strength in Children With Diabetes Mellitus Type 1 Completed NCT01277913 Phase 4 Vitamin D3;Vitamin D3
2 A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT Not yet recruiting NCT03176849 Phase 4
3 Randomized Study of Two Vitamin D Dosing Strategies in Children With Chronic Kidney Disease Active, not recruiting NCT01909115 Phase 3
4 Prevention of Vitamin D Deficiency Following Pediatric CHD Surgery: a Phase II Dose Evaluation Randomized Controlled Trial Comparing Usual Care With a High Dose Pre-operative Supplementation Regimen Based on the Institute of Medicine Daily Upper Tolerable Completed NCT01838447 Phase 2
5 Vitamin D as a Modifier of Serum Hepcidin in Children With Chronic Kidney Disease Completed NCT01532349 Phase 2 Cholecalciferol
6 Vitamin D and Severe Asthma Exacerbations Completed NCT01921894 Phase 1
7 Pilot Trial to Evaluate the Effect of Vitamin D on Melanocyte Biomarkers Completed NCT01477463 Not Applicable Vitamin D3;placebo and vitamin D
8 Efficacy of Vitamin D Therapy on Glucose Homeostasis in Obese Adolescents Completed NCT02414529 Not Applicable Vitamin D2;Placebo
9 Change in Free 25(OH)D After High Dose in Vitamin D Deficient Postmenopausal Women Active, not recruiting NCT02553044 Not Applicable
10 Dose-dependent Effects of Vitamin D on Bone Health Active, not recruiting NCT01900860 Not Applicable

Search NIH Clinical Center for Hypervitaminosis D

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Genetic Tests for Hypervitaminosis D

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Anatomical Context for Hypervitaminosis D

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MalaCards organs/tissues related to Hypervitaminosis D:

41
Bone, Kidney, Placenta, Smooth Muscle
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Publications for Hypervitaminosis D

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Articles related to Hypervitaminosis D:

(show top 50) (show all 119)
# Title Authors Year
1
SUSPECTED HYPERVITAMINOSIS D IN RED-RUMPED AGOUTI ( DASYPROCTA LEPORINA) RECEIVING A COMMERCIAL RODENT DIET. ( 29517453 )
2018
2
Hypervitaminosis D Associated With Tanning Bed Use: A Case Report. ( 28114469 )
2017
3
Can adverse effects of excessive vitamin D supplementation occur without developing hypervitaminosis D? ( 28734988 )
2017
4
Vitamin D deficiency: It is time for reality check of the epidemiology. Re. "The increasing problem of subclinical and overt hypervitaminosis D in India: An institutional experience and review." ( 28652074 )
2017
5
The increasing problem of subclinical and overt hypervitaminosis D in India: An institutional experience and review. ( 28063517 )
2017
6
Prevalence of hypercalcemia related to hypervitaminosis D in clinical practice. ( 26995293 )
2016
7
Hypervitaminosis D with Dyslipidemia: An Unusual Scenario. ( 26897163 )
2016
8
Clinical investigation into feed-related hypervitaminosis D in a captive flock of budgerigars (Melopsittacus undulatus): morbidity, mortalities, and pathologic lesions. ( 25831571 )
2015
9
Reversible vascular calcifications associated with hypervitaminosis D. ( 26318020 )
2015
10
Acute Hypercalcaemia and Hypervitaminosis D in an Infant with Extra Pulmonary Tuberculosis. ( 26557587 )
2015
11
Hypervitaminosis-D, an uncommon reality! ( 25906526 )
2014
12
Hypervitaminosis D and Metastatic Calcification in a Colony of Inbred Strain 13 Guinea Pigs, Cavia porcellus. ( 25281651 )
2014
13
Tanning beds and hypervitaminosis D: a case report. ( 24887628 )
2014
14
Iatrogenic hypervitaminosis D as an unusual cause of persistent vomiting: a case report. ( 24571630 )
2014
15
Maternal hypervitaminosis D reduces fetal bone mass and mineral acquisition and leads to neonatal lethality. ( 23895994 )
2013
16
Early life permethrin exposure leads to hypervitaminosis D, nitric oxide and catecholamines impairment. ( 25149241 )
2013
17
Hypervitaminosis D in guinea pigs with I+-mannosidosis. ( 23582422 )
2013
18
Treatment of nephrogenic diabetes insipidus due to hypervitaminosis D. ( 23756934 )
2013
19
Hypervitaminosis D causing nephrogenic diabetes insipidus in a 5-month-old infant. ( 23396467 )
2013
20
"Excess gooD can be Dangerous". A case series of iatrogenic symptomatic hypercalcemia due to hypervitaminosis D. ( 23087723 )
2012
21
Serum levels of 3-epi-25-OH-D3 during hypervitaminosis D in clinical practice. ( 23038681 )
2012
22
Hypervitaminosis D: case report of pediatric osteoporosis secondary to cystic fibrosis. ( 22461833 )
2011
23
Hypervitaminosis D associated with a vitamin D dispensing error. ( 21917555 )
2011
24
Neurofibromatosis, pathological fracture and hypervitaminosis-D. ( 21048240 )
2010
25
Pseudotumor cerebri due to hypervitaminosis A or hypervitaminosis D or both in Alagille syndrome. ( 19619235 )
2010
26
Hypercalcemia due to hypervitaminosis D: report of seven patients. ( 19339514 )
2009
27
Ventricular-arterial coupling in a rat model of reduced arterial compliance provoked by hypervitaminosis D and nicotine. ( 16699077 )
2006
28
Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice. ( 16731043 )
2006
29
Hypervitaminosis D mediates compensatory Ca2+ hyperabsorption in TRPV5 knockout mice. ( 16148038 )
2005
30
Risk of hypervitaminosis D from prolonged feeding of high vitamin D premature infant formula. ( 15310310 )
2004
31
1,25-dihydroxyvitamin D3 receptor is upregulated in aortic smooth muscle cells during hypervitaminosis D. ( 12002522 )
2002
32
Hypercalcemia and hypervitaminosis D in two lambs. ( 10754674 )
2000
33
Effects of plant-induced hypervitaminosis D on cutaneous structure, cell differentiation and cell proliferation in cattle. ( 10887751 )
2000
34
Hypervitaminosis D: Report on three patients. ( 17341976 )
1998
35
Dental changes in hypervitaminosis D. ( 9574950 )
1998
36
[Hypervitaminosis D in institutionalized elderly in Buenos Aires]. ( 9435366 )
1997
37
An outbreak of hypervitaminosis D associated with the overfortification of milk from a home-delivery dairy. ( 7733425 )
1995
38
Hypervitaminosis D after prolonged feeding with a premature formula. ( 8233752 )
1993
39
Hypervitaminosis D associated with drinking milk. ( 1313547 )
1992
40
Up-regulation of the intestinal 1,25-dihydroxyvitamin D receptor during hypervitaminosis D: a comparison between vitamin D2 and vitamin D3. ( 2163637 )
1990
41
Effect of ethane-I-hydroxy-I, I-diphosphonate on arterial calcinosis induced by hypervitaminosis D: a morphologic investigation. ( 2109995 )
1990
42
Ultrastructural study of hypervitaminosis D induced arterial calcification in Wistar rats. ( 3207390 )
1988
43
Dietary magnesium effect on swine coronary atherosclerosis induced by hypervitaminosis D. ( 2820185 )
1987
44
Severe depressive illness in the context of hypervitaminosis D. ( 3664111 )
1987
45
The osteodystrophy of hypervitaminosis D: a metabolic study. ( 3498181 )
1986
46
Hypervitaminosis D in the chick embryo: comparative study on the activity of various vitamin D3 metabolites. ( 6091851 )
1984
47
Effect of alkali on metastatic calcification produced by hypervitaminosis D. ( 6098694 )
1984
48
The role of 25-hydroxy-vitamin D3 in the induction of atherosclerosis in swine and rabbit by hypervitaminosis D. ( 6837312 )
1983
49
Direct measurement of bone resorption and calcium conservation during vitamin D deficiency or hypervitaminosis D. ( 6246506 )
1980
50
Effect of hypervitaminosis D on skeletal plutonium levels in mice. ( 7429853 )
1980
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Variations for Hypervitaminosis D

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Expression for Hypervitaminosis D

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Search GEO for disease gene expression data for Hypervitaminosis D.
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Pathways for Hypervitaminosis D

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Pathways related to Hypervitaminosis D according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Negative regulation of FGFR3 signaling 66
Show member pathways
 12.15 FGF23 GALNT3 KL
2
Signaling by FGFR2 66
Show member pathways
 11.83 FGF23 GALNT3 KL
3
FGFR3 mutant receptor activation 66
Show member pathways
 11.24 FGF23 GALNT3
4
Parathyroid hormone synthesis, secretion and action 37
11.13 CYP27B1 FGF23 KL PTH TRPV5 VDR
5
Endocrine and other factor-regulated calcium reabsorption 37
11.1 KL TRPV5 VDR
6
Development_Hedgehog and PTH signaling pathways in bone and cartilage development 22
11.02 PTH VDR
7
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
10.99 CYP27B1 PTH VDR
8
Nuclear Receptors in Lipid Metabolism and Toxicity 1
10.95 CYP27B1 VDR
9
Osteoblast Signaling 1
10.47 FGF23 PTH
10
Vitamin D Metabolism 1
10.13 CYP27B1 PTH VDR
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GO Terms for Hypervitaminosis D

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Biological processes related to Hypervitaminosis D according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.71 FGF23 KL PTH
2 calcium ion transport GO:0006816 9.58 CYP27B1 TRPV5 VDR
3 cellular calcium ion homeostasis GO:0006874 9.55 PTH VDR
4 fibroblast growth factor receptor signaling pathway GO:0008543 9.54 FGF23 GALNT3 KL
5 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.52 FGF23 KL
6 positive regulation of bone mineralization GO:0030501 9.51 KL PTH
7 decidualization GO:0046697 9.49 CYP27B1 VDR
8 regulation of bone mineralization GO:0030500 9.48 CYP27B1 FGF23
9 response to vitamin D GO:0033280 9.46 CYP27B1 PTH
10 positive regulation of keratinocyte differentiation GO:0045618 9.43 CYP27B1 VDR
11 calcium ion homeostasis GO:0055074 9.33 CYP27B1 KL TRPV5
12 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 9.32 FGF23 KL
13 vitamin D catabolic process GO:0042369 9.26 CYP27B1 FGF23
14 vitamin D metabolic process GO:0042359 9.13 CYP27B1 FGF23 VDR
15 positive regulation of vitamin D 24-hydroxylase activity GO:0010980 8.8 CYP27B1 FGF23 VDR

Molecular functions related to Hypervitaminosis D according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.26 FGF23 KL
2 1-phosphatidylinositol-3-kinase activity GO:0016303 9.16 FGF23 KL
3 fibroblast growth factor receptor binding GO:0005104 8.96 FGF23 KL
4 vitamin D binding GO:0005499 8.62 KL VDR
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Sources for Hypervitaminosis D

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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