Aliases & Classifications for Hypervitaminosis D

MalaCards integrated aliases for Hypervitaminosis D:

Name: Hypervitaminosis D 12 74 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:9971
ICD9CM 34 278.4
SNOMED-CT 67 27712000
ICD10 32 E67.3
UMLS 71 C1442839

Summaries for Hypervitaminosis D

Disease Ontology : 12 An overnutrition that is characterized by elevated vitamin D, which can subsequently cause high levels of calcium, has symptom myalgia, fatigue, irritability, nausea, dehydration, polyuria, and nephrocalcinosis, and possibly has material basis in excess intake of vitamin D.

MalaCards based summary : Hypervitaminosis D is related to arterial calcification of infancy and nephrocalcinosis, and has symptoms including myalgia An important gene associated with Hypervitaminosis D is PTH (Parathyroid Hormone), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Metabolism of fat-soluble vitamins. The drugs Vitamin D and Ergocalciferol have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and liver, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 74 Hypervitaminosis D is a state of vitamin D toxicity. The normal range for blood concentration is 20 to... more...

Related Diseases for Hypervitaminosis D

Diseases in the Hypervitaminosis a family:

Hypervitaminosis D

Diseases related to Hypervitaminosis D via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 arterial calcification of infancy 32.3 KL GALNT3 FGF23
2 nephrocalcinosis 30.4 TRPV5 PTH FGF23 CYP24A1
3 calcinosis 30.1 KL GALNT3 FGF23 CALCA
4 hyperphosphatemia 29.5 VDR PTH KL GALNT3 FGF23
5 renal osteodystrophy 29.5 VDR PTH FGF23 CALCA
6 nephrolithiasis 29.5 VDR TRPV5 PTH FGF23 CYP24A1
7 bone resorption disease 28.8 VDR PTHLH PTH FGF23 CALCA
8 hypoparathyroidism 28.8 VDR PTHLH PTH FGF23 CALCA
9 hypophosphatemia 28.7 VDR PTHLH PTH KL FGF23 CYP27B1
10 rickets 28.4 VDR PTH KL GC FGF23 CYP2R1
11 hypocalcemia, autosomal dominant 1 28.3 VDR PTHLH PTH FGF23 CYP27B1 CALCA
12 secondary hyperparathyroidism 28.1 VDR PTH KL GC FGF23 CYP27B1
13 hyperparathyroidism 27.5 VDR TRPV6 PTHLH PTH KL GC
14 osteoporosis 27.1 VDR PTHLH PTH KL GC FGF23
15 enthesopathy 10.3 KL FGF23
16 dental pulp calcification 10.3 KL GALNT3
17 bone benign neoplasm 10.3 PTH FGF23
18 hyperlipoproteinemia, type v 10.3 KL FGF23
19 vitamin d-dependent rickets, type 2a 10.3 VDR CYP27B1
20 tuberculous epididymitis 10.3 VDR CYP27B1
21 idiopathic hypercalciuria 10.3 VDR TRPV5
22 nephrolithiasis/osteoporosis, hypophosphatemic, 1 10.3 PTH KL FGF23
23 tracheal calcification 10.2 PTH KL FGF23
24 spondylosis 10.2 VDR PTH KL
25 pulmonary alveolar microlithiasis 10.2 GALNT3 FGF23
26 calciphylaxis 10.2 VDR PTH FGF23
27 metatropic dysplasia 10.2 TRPV6 TRPV5
28 arteriosclerosis 10.2
29 conjunctival deposit 10.2 KL GALNT3 FGF23
30 hypophosphatemic rickets with hypercalciuria, hereditary 10.2 PTH GALNT3 FGF23
31 familial tumoral calcinosis 10.1 KL GALNT3 FGF23
32 idiopathic infantile hypercalcemia 10.1 PDLIM1 CYP24A1
33 osteoglophonic dysplasia 10.1 KL GALNT3 FGF23
34 substernal goiter 10.1 PTH CALCA
35 scapuloperoneal spinal muscular atrophy 10.1 TRPV6 TRPV5
36 hyperostosis 10.1 KL GALNT3 FGF23
37 hypocalcemic vitamin d-dependent rickets 10.1 CYP2R1 CYP27B1
38 aromatase deficiency 10.1 TRPV6 TRPV5
39 endemic goiter 10.1 PTH CALCA
40 nontoxic goiter 10.1 PTH CALCA
41 diabetes insipidus, nephrogenic, autosomal 10.1
42 endosteal hyperostosis, autosomal dominant 10.1
43 pulmonary tuberculosis 10.1
44 diabetes insipidus 10.1
45 premature aging 10.1
46 giant cell reparative granuloma 10.1 PTH CALCA
47 skin atrophy 10.0 TRPV5 KL FGF23 CYP27B1
48 pediatric ovarian germ cell tumor 10.0 PTHLH PTH
49 pediatric ovarian dysgerminoma 10.0 PTHLH PTH
50 graves disease 1 10.0 PTH CALCA

Graphical network of the top 20 diseases related to Hypervitaminosis D:



Diseases related to Hypervitaminosis D

Symptoms & Phenotypes for Hypervitaminosis D

Symptoms:

12
  • myalgia

MGI Mouse Phenotypes related to Hypervitaminosis D:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.13 CYP24A1 CYP27B1 FGF23 GALNT3 KL PTH
2 homeostasis/metabolism MP:0005376 10.11 CYP24A1 CYP27B1 CYP2R1 FGF23 GALNT3 GC
3 endocrine/exocrine gland MP:0005379 10.06 CYP27B1 FGF23 GALNT3 GC KL PTH
4 hematopoietic system MP:0005397 10.06 CYP27B1 FGF23 GALNT3 KL PDLIM1 PTH
5 craniofacial MP:0005382 9.97 CYP27B1 GALNT3 KL PTH PTHLH VDR
6 immune system MP:0005387 9.97 CYP27B1 FGF23 GALNT3 KL PDLIM1 PTH
7 digestive/alimentary MP:0005381 9.95 FGF23 GALNT3 KL PTHLH TRPV5 VDR
8 limbs/digits/tail MP:0005371 9.8 CYP27B1 FGF23 GALNT3 KL PTH PTHLH
9 renal/urinary system MP:0005367 9.76 CYP24A1 CYP27B1 FGF23 GALNT3 KL PTHLH
10 reproductive system MP:0005389 9.56 CYP24A1 CYP27B1 FGF23 GALNT3 KL PTHLH
11 skeleton MP:0005390 9.36 CYP24A1 CYP27B1 CYP2R1 FGF23 GALNT3 GC

Drugs & Therapeutics for Hypervitaminosis D

Drugs for Hypervitaminosis D (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2 1406-16-2
2
Ergocalciferol Approved, Nutraceutical Phase 2 50-14-6 5280793
3 Trace Elements Phase 2
4 Vitamins Phase 2
5 Nutrients Phase 2
6 Calciferol Phase 2
7 Micronutrients Phase 2
8 Ergocalciferols Phase 2
9 Hormones Phase 2
10 Calcium, Dietary Phase 2
11 Vitamin D2 Phase 2
12
Calcium Nutraceutical Phase 2 7440-70-2 271
13
Lidocaine Approved, Vet_approved 137-58-6 3676
14
Vitamin D3 Approved, Nutraceutical 67-97-0 5280795 6221
15 Insulin, Globin Zinc
16 insulin
17 Vaccines

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vitamin D Dose-Response Study to Establish Dietary Requirements in Infants Completed NCT00381914 Phase 2 Vitamin D;Vitamin D;Vitamin D
2 A Comparative Study to Assess Efficacy of Intralesional MMR (Measles, Mumps, Rubella) Vaccine and Intralesional Vitamin D3 in Treatment of Warts Not yet recruiting NCT04428359 Measles-Mumps-Rubella Vaccine;Vit D

Search NIH Clinical Center for Hypervitaminosis D

Genetic Tests for Hypervitaminosis D

Anatomical Context for Hypervitaminosis D

MalaCards organs/tissues related to Hypervitaminosis D:

40
Bone, Kidney, Liver, Lung, Heart, Smooth Muscle, Skin

Publications for Hypervitaminosis D

Articles related to Hypervitaminosis D:

(show top 50) (show all 344)
# Title Authors PMID Year
1
Biallelic CYP24A1 variants presenting during pregnancy: clinical and biochemical phenotypes. 61
32375123 2020
2
Hypercalcemia, nephrolithiasis, and hypervitaminosis D precipitated by supplementation in a susceptible individual. 61
32222584 2020
3
Development and application of a LC-MS/MS assay for simultaneous analysis of 25-hydroxyvitamin-D and 3-epi-25-hydroxyvitamin-D metabolites in canine serum. 61
31958632 2020
4
Long-term hypervitaminosis D-induced hypercalcaemia treated with glucocorticoids and bisphosphonates. 61
32354763 2020
5
HYPERVITAMINOSIS D IN A GIANT ANTEATER (MYRMECOPHAGA TRIDACTYLA) AND A LARGE HAIRY ARMADILLO (CHAETOPHRACTUS VILLOSUS) RECEIVING A COMMERCIAL INSECTIVORE DIET. 61
32212572 2020
6
Hypervitaminosis D without toxicity. 61
32063764 2020
7
Toxicity of Herbs, Vitamins, and Supplements. 61
32147004 2020
8
Hypervitaminosis D has no positive effects on goat tuberculosis and may cause chronic renal lesions. 61
31690642 2019
9
Intractable hypercalcaemia during pregnancy and the postpartum secondary to pathogenic variants in CYP24A1. 61
31751313 2019
10
Hypercalcemia Without Hypervitaminosis D During Cholecalciferol Supplementation in Critically Ill Patients. 61
31605425 2019
11
Normocalcemia in the Face of Marked Hypervitaminosis D: The Utility of Vitamin D Metabolite Profiling. 61
31639673 2019
12
Hypercalcaemia due to Hypervitaminosis D in a Self-Supplementing Multiple Sclerosis Patient: A Case Report 61
31538442 2019
13
A randomised trial of vitamin D in acute-stage allergic bronchopulmonary aspergillosis complicating asthma. 61
30561849 2019
14
Appearances of soft tissue calcification on Tc99m MDP bone scan. 61
31000873 2019
15
Calcioic acid: In vivo detection and quantification of the terminal C24-oxidation product of 25-hydroxyvitamin D3 and related intermediates in serum of mice treated with 24,25-dihydroxyvitamin D3. 61
30553931 2019
16
Expansive Vascular Remodeling and Increased Vascular Calcification Response to Cholecalciferol in a Murine Model of Obesity and Insulin Resistance. 61
30580565 2019
17
Laboratory trend in vitamin D status in Ireland: Dual concerns about low and high 25OHD. 61
30296586 2019
18
Effect of molting on the concentration of plasma 25-hydroxyvitamin D in captive African penguins (Spheniscus demersus). 61
30308304 2019
19
Acute hypercalcemia and hypervitaminosis D associated with pulmonary tuberculosis in an elderly patient : A case report and review of the literature. 61
31656304 2019
20
Severity of Ionized Hypercalcemia and Hypocalcemia Is Associated With Etiology in Dogs and Cats. 61
31508432 2019
21
Redundancy Is of No Good; Iatrogenic Hypervitaminosis D: A Rare Case of Persistent Vomiting Due to Hypercalcemia. 61
30792578 2019
22
CYP24A1 mutations and hypervitaminosis D. 61
30651269 2019
23
Efficacy and Safety of 90,000 IU versus 300,000 IU Single Dose Oral Vitamin D in Nutritional Rickets: A Randomized Controlled Trial. 61
30766814 2018
24
Open-label study of treatment with alendronate sodium plus vitamin D in men and women with osteoporosis in Thailand. 61
30400864 2018
25
Increased rates of 25-hydroxy vitamin D testing: Dissecting a modern epidemic. 61
30026017 2018
26
Multiple renal calculi due to hypercalcaemia induced by over-the-counter vitamin D intoxication. 61
30131404 2018
27
Response to Long-term Vitamin D Therapy for Bone Disease in Children With Sickle Cell Disease. 61
29668535 2018
28
Risks of the 'Sunshine pill' - a case of hypervitaminosis D. 61
30072556 2018
29
Can adverse effects of excessive vitamin D supplementation occur without developing hypervitaminosis D? 61
28734988 2018
30
Soluble Klotho causes hypomineralization in Klotho-deficient mice. 61
29632215 2018
31
SUSPECTED HYPERVITAMINOSIS D IN RED-RUMPED AGOUTI ( DASYPROCTA LEPORINA) RECEIVING A COMMERCIAL RODENT DIET. 61
29517453 2018
32
Acute fish liver intoxication induced blisters formation and generalized skin peeling. 61
28841060 2018
33
Hypercalcemic pancreatitis a rare presentation of sarcoidosis: A case report. 61
29480854 2018
34
Vitamin D Toxicity-A Clinical Perspective. 61
30294301 2018
35
Vitamin D deficiency: Time for a reality check of the epidemiology. Re. "The increasing problem of subclinical and overt hypervitaminosis D in India: An institutional experience and review." 61
28652074 2018
36
How much is too much? Two contrasting cases of excessive vitamin D supplementation. 61
28801091 2017
37
Vitamin D in human reproduction: the more, the better? An evidence-based critical appraisal. 61
29028072 2017
38
Vitamin D toxicity of dietary origin in cats fed a natural complementary kitten food. 61
29270305 2017
39
Bi-allelic IARS mutations in a child with intra-uterine growth retardation, neonatal cholestasis, and mild developmental delay. 61
27891590 2017
40
The increasing problem of subclinical and overt hypervitaminosis D in India: An institutional experience and review. 61
28063517 2017
41
Hypervitaminosis D Associated With Tanning Bed Use: A Case Report. 61
28114469 2017
42
Prevalence of hypercalcemia related to hypervitaminosis D in clinical practice. 61
26995293 2016
43
Reduction of serum 25-hydroxyvitamin D concentrations with intravenous lipid emulsion in a dog. 61
27928177 2016
44
Influence hypervitaminosis D3 on hemodynamic presentation of experimental copper intoxication. 61
29244912 2016
45
Effect of intramuscular cholecalciferol megadose in children with nutritional rickets. 61
26913455 2016
46
Hypervitaminosis D with Dyslipidemia: An Unusual Scenario. 61
26897163 2016
47
Reversible vascular calcifications associated with hypervitaminosis D. 61
26318020 2016
48
[Hypervitaminosis D due to a dietary supplement]. 61
27071359 2016
49
A 23-year-old patient with secondary tumoral calcinosis: Regression after subtotal parathyroidectomy: A case report. 61
27088846 2016
50
Dystrophic mineralization of the arterial fibrovascular tissue associated with a vitamin D hypervitaminosis in an 8-year-old female Alpaca (Vicugna pacos). 61
28018578 2016

Variations for Hypervitaminosis D

Expression for Hypervitaminosis D

Search GEO for disease gene expression data for Hypervitaminosis D.

Pathways for Hypervitaminosis D

Pathways related to Hypervitaminosis D according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.38 GC CYP2R1 CYP27B1 CYP24A1
2
Show member pathways
12.04 GC CYP2R1 CYP27B1 CYP24A1
3
Show member pathways
11.99 KL GALNT3 FGF23
4 11.84 PTHLH PTH CALCA
5 11.58 VDR TRPV5 PTHLH PTH KL FGF23
6
Show member pathways
11.49 CYP2R1 CYP27B1 CYP24A1
7 11.28 VDR TRPV5 PTH KL
8 11.21 VDR PTH CYP27B1 CYP24A1 CALCA
9 11.14 VDR PTHLH PTH
10 11.04 VDR CYP27B1 CYP24A1
11 10.91 TRPV6 TRPV5
12 10.6 PTH FGF23
13 10.1 VDR PTH GC CYP2R1 CYP27B1 CYP24A1

GO Terms for Hypervitaminosis D

Biological processes related to Hypervitaminosis D according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.77 VDR PTHLH PTH
2 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.74 PTHLH PTH CALCA
3 calcium ion transport GO:0006816 9.73 VDR TRPV6 TRPV5 CYP27B1
4 cellular calcium ion homeostasis GO:0006874 9.72 VDR PTH CALCA
5 fibroblast growth factor receptor signaling pathway GO:0008543 9.71 KL GALNT3 FGF23
6 decidualization GO:0046697 9.61 VDR CYP27B1
7 regulation of bone mineralization GO:0030500 9.59 FGF23 CYP27B1
8 negative regulation of chondrocyte differentiation GO:0032331 9.58 PTHLH PTH
9 positive regulation of keratinocyte differentiation GO:0045618 9.58 VDR CYP27B1
10 calcium ion import across plasma membrane GO:0098703 9.56 TRPV6 TRPV5
11 response to vitamin D GO:0033280 9.54 PTH CYP27B1 CYP24A1
12 phosphate ion homeostasis GO:0055062 9.52 PTH FGF23
13 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 9.51 KL FGF23
14 vitamin metabolic process GO:0006766 9.5 CYP2R1 CYP27B1 CYP24A1
15 calcitriol biosynthetic process from calciol GO:0036378 9.49 CYP2R1 CYP27B1
16 vitamin D receptor signaling pathway GO:0070561 9.48 VDR CYP24A1
17 cAMP metabolic process GO:0046058 9.46 PTHLH PTH
18 vitamin D catabolic process GO:0042369 9.43 FGF23 CYP27B1 CYP24A1
19 vitamin D biosynthetic process GO:0042368 9.4 CYP2R1 CYP27B1
20 calcium ion homeostasis GO:0055074 9.35 TRPV6 TRPV5 PTH KL CYP27B1
21 positive regulation of vitamin D 24-hydroxylase activity GO:0010980 9.33 VDR FGF23 CYP27B1
22 vitamin D metabolic process GO:0042359 9.1 VDR GC FGF23 CYP2R1 CYP27B1 CYP24A1

Molecular functions related to Hypervitaminosis D according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.58 CYP2R1 CYP27B1 CYP24A1
2 iron ion binding GO:0005506 9.54 CYP2R1 CYP27B1 CYP24A1
3 monooxygenase activity GO:0004497 9.5 CYP2R1 CYP27B1 CYP24A1
4 fibroblast growth factor receptor binding GO:0005104 9.43 KL FGF23
5 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.33 CYP2R1 CYP27B1 CYP24A1
6 peptide hormone receptor binding GO:0051428 9.26 PTHLH PTH
7 hormone activity GO:0005179 9.26 PTHLH PTH KL CALCA
8 vitamin D binding GO:0005499 8.8 VDR KL GC

Sources for Hypervitaminosis D

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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