Hypervitaminosis D disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HYP057 MIFTS: 42	Hypervitaminosis D Categories: Metabolic diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

Sources

Aliases & Classifications for Hypervitaminosis D

MalaCards integrated aliases for Hypervitaminosis D:

Name: Hypervitaminosis D ¹² ⁷⁴ ¹⁵ ⁷¹ ³²

Classifications:

MalaCards categories:
Global: Metabolic diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Endocrine, nutritional and metabolic diseases

Obesity and other hyperalimentation

Other hyperalimentation

Hypervitaminosis D

External Ids:

Disease Ontology ¹² DOID:9971

ICD9CM ³⁴ 278.4

SNOMED-CT ⁶⁷ 27712000

ICD10 ³² E67.3

UMLS ⁷¹ C1442839

Sources

Summaries for Hypervitaminosis D

Disease Ontology : ¹² An overnutrition that is characterized by elevated vitamin D, which can subsequently cause high levels of calcium, has symptom myalgia, fatigue, irritability, nausea, dehydration, polyuria, and nephrocalcinosis, and possibly has material basis in excess intake of vitamin D.

MalaCards based summary : Hypervitaminosis D is related to arterial calcification of infancy and nephrocalcinosis, and has symptoms including myalgia An important gene associated with Hypervitaminosis D is PTH (Parathyroid Hormone), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Metabolism of fat-soluble vitamins. The drugs Vitamin D and Ergocalciferol have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and liver, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : ⁷⁴ Hypervitaminosis D is a state of vitamin D toxicity. The normal range for blood concentration is 20 to... more...

Sources

Related Diseases for Hypervitaminosis D

Diseases in the Hypervitaminosis a family:

Hypervitaminosis D

Diseases related to Hypervitaminosis D via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)

#	Related Disease	Score	Top Affiliating Genes
1	arterial calcification of infancy	32.3	KL GALNT3 FGF23
2	nephrocalcinosis	30.4	TRPV5 PTH FGF23 CYP24A1
3	calcinosis	30.1	KL GALNT3 FGF23 CALCA
4	hyperphosphatemia	29.5	VDR PTH KL GALNT3 FGF23
5	renal osteodystrophy	29.5	VDR PTH FGF23 CALCA
6	nephrolithiasis	29.5	VDR TRPV5 PTH FGF23 CYP24A1
7	bone resorption disease	28.8	VDR PTHLH PTH FGF23 CALCA
8	hypoparathyroidism	28.8	VDR PTHLH PTH FGF23 CALCA
9	hypophosphatemia	28.7	VDR PTHLH PTH KL FGF23 CYP27B1
10	rickets	28.4	VDR PTH KL GC FGF23 CYP2R1
11	hypocalcemia, autosomal dominant 1	28.3	VDR PTHLH PTH FGF23 CYP27B1 CALCA
12	secondary hyperparathyroidism	28.1	VDR PTH KL GC FGF23 CYP27B1
13	hyperparathyroidism	27.5	VDR TRPV6 PTHLH PTH KL GC
14	osteoporosis	27.1	VDR PTHLH PTH KL GC FGF23
15	enthesopathy	10.3	KL FGF23
16	dental pulp calcification	10.3	KL GALNT3
17	bone benign neoplasm	10.3	PTH FGF23
18	hyperlipoproteinemia, type v	10.3	KL FGF23
19	vitamin d-dependent rickets, type 2a	10.3	VDR CYP27B1
20	tuberculous epididymitis	10.3	VDR CYP27B1
21	idiopathic hypercalciuria	10.3	VDR TRPV5
22	nephrolithiasis/osteoporosis, hypophosphatemic, 1	10.3	PTH KL FGF23
23	tracheal calcification	10.2	PTH KL FGF23
24	spondylosis	10.2	VDR PTH KL
25	pulmonary alveolar microlithiasis	10.2	GALNT3 FGF23
26	calciphylaxis	10.2	VDR PTH FGF23
27	metatropic dysplasia	10.2	TRPV6 TRPV5
28	arteriosclerosis	10.2
29	conjunctival deposit	10.2	KL GALNT3 FGF23
30	hypophosphatemic rickets with hypercalciuria, hereditary	10.2	PTH GALNT3 FGF23
31	familial tumoral calcinosis	10.1	KL GALNT3 FGF23
32	idiopathic infantile hypercalcemia	10.1	PDLIM1 CYP24A1
33	osteoglophonic dysplasia	10.1	KL GALNT3 FGF23
34	substernal goiter	10.1	PTH CALCA
35	scapuloperoneal spinal muscular atrophy	10.1	TRPV6 TRPV5
36	hyperostosis	10.1	KL GALNT3 FGF23
37	hypocalcemic vitamin d-dependent rickets	10.1	CYP2R1 CYP27B1
38	aromatase deficiency	10.1	TRPV6 TRPV5
39	endemic goiter	10.1	PTH CALCA
40	nontoxic goiter	10.1	PTH CALCA
41	diabetes insipidus, nephrogenic, autosomal	10.1
42	endosteal hyperostosis, autosomal dominant	10.1
43	pulmonary tuberculosis	10.1
44	diabetes insipidus	10.1
45	premature aging	10.1
46	giant cell reparative granuloma	10.1	PTH CALCA
47	skin atrophy	10.0	TRPV5 KL FGF23 CYP27B1
48	pediatric ovarian germ cell tumor	10.0	PTHLH PTH
49	pediatric ovarian dysgerminoma	10.0	PTHLH PTH
50	graves disease 1	10.0	PTH CALCA

Graphical network of the top 20 diseases related to Hypervitaminosis D:

Sources

Symptoms & Phenotypes for Hypervitaminosis D

Symptoms:

¹²

• myalgia

MGI Mouse Phenotypes related to Hypervitaminosis D:

⁴⁵ (show all 11)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	10.13	CYP24A1 CYP27B1 FGF23 GALNT3 KL PTH
2	homeostasis/metabolism	MP:0005376	10.11	CYP24A1 CYP27B1 CYP2R1 FGF23 GALNT3 GC
3	endocrine/exocrine gland	MP:0005379	10.06	CYP27B1 FGF23 GALNT3 GC KL PTH
4	hematopoietic system	MP:0005397	10.06	CYP27B1 FGF23 GALNT3 KL PDLIM1 PTH
5	craniofacial	MP:0005382	9.97	CYP27B1 GALNT3 KL PTH PTHLH VDR
6	immune system	MP:0005387	9.97	CYP27B1 FGF23 GALNT3 KL PDLIM1 PTH
7	digestive/alimentary	MP:0005381	9.95	FGF23 GALNT3 KL PTHLH TRPV5 VDR
8	limbs/digits/tail	MP:0005371	9.8	CYP27B1 FGF23 GALNT3 KL PTH PTHLH
9	renal/urinary system	MP:0005367	9.76	CYP24A1 CYP27B1 FGF23 GALNT3 KL PTHLH
10	reproductive system	MP:0005389	9.56	CYP24A1 CYP27B1 FGF23 GALNT3 KL PTHLH
11	skeleton	MP:0005390	9.36	CYP24A1 CYP27B1 CYP2R1 FGF23 GALNT3 GC

Sources

Drugs & Therapeutics for Hypervitaminosis D

Drugs for Hypervitaminosis D (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Vitamin D

Approved, Nutraceutical, Vet_approved

Phase 2

1406-16-2

Ergocalciferol

Approved, Nutraceutical

Phase 2

50-14-6

5280793

Synonyms:

(+)-Vitamin D2

(3b,5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol

(3beta,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol

(3beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol

(3-beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10,(19),22-tetraen-3-ol

(3S,5Z,7E,14xi,17alpha,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol

(3S,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol

(3S,5Z,7E,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol

(3β,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol

(5E,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraen-3-ol

(5Z,7E,22E)-(3S)-9,10-seco-5,7,10(19),22-ergostatetraen-3-ol

(5Z,7E,22E)-(3S)-9,10-seco-5,7,10(19),22-Ergostatetraen-3-ol

(5Z,7E,22E)-(3S)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol

(5Z,7E,22E)-(3S)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol

22-Tetraen 3beta 9,10,secoergosta-5,7,10(19)-ol

31316-19-5

47768_SUPELCO

4-Methylene-3-[2-[tetrahydro-7a-methyl-1-(1,4,5-trimethyl-2-hexenyl)-4(3ah)-indanylidene]ethylidene]-cyclohexanol

50-14-6

7489-18-1

7E677DC1-E1C4-4FC5-8F4A-BCE1857F7E87

8017-28-5

9,10,Secoergosta-5,7,10(19),22-tetraen 3.beta.-ol

9,10-Seco(5Z,7E,22E)-5,7,10(19),22-ergostatetraen-3-ol

9,10-Secoergosta-5,7,10(19),22-tetraen-3-beta-ol

9,10-Secoergosta-5,7,10(19),22-tetraen-3b-ol

95220_FLUKA

95220_SIGMA

AC-1355

AC1L1FIE

AC1NQXLH

AC1NS4DE

AC1NS9GI

AC1NSSVD

AC1NWAM3

AC1O5EDK

AC1O6WAM

ACon1_002187

Activated ergosterol

beta-Ol

bmse000510

BPBio1_000418

BSPBio_000380

BSPBio_001974

buco-D

Buco-D

C05441

C28H44O

Calciferol

Calciferol (TN)

Calciferol (vitamin D2)

CALCIFEROL IN A GELATIN MATRIX

CALCIFEROL, U.S.P.

Calciferols

Calciferolum

Calciferon 2

CHEBI:28934

CHEMBL1536

CID11003810

CID3249

CID5280793

CID5315257

CID5353610

CID5356615

CID5702050

CID6432478

CID6536972

component of Geltabs Vitamin D

Condacaps

Condocaps

Condol

Crtron

Crystallina

D00187

D2, Vitamin

Daral

D-Arthin

Davitamon D

Davitin

DB00153

Decaps

Dee-osterol

Dee-Osterol

Dee-ron

Dee-Ron

Dee-ronal

Dee-Ronal

Dee-roual

Dee-Roual

delta-Arthin

Deltalin

delta-Tracetten

De-rat concentrate

Deratol

Detalup

Diactol

Divit urto

Doral

Drisdol

Drisdol (TN)

D-Tracetten

E5750_SIGMA

EINECS 200-014-9

Ercalciol

ergocalciferol

Ergocalciferol

Ergocalciférol

Ergocalciferol (D2)

Ergocalciferol (JP15/USP)

Ergocalciferol [INN:BAN:JAN]

Ergocalciferol oil

Ergocalciferol: Vitamin D

Ergocalciferolo

Ergocalciferolo [DCIT]

Ergocalciferols

Ergocalciferolum

Ergocalciferolum [INN-Latin]

Ergorone

Ergosterol activated

Ergosterol irradiated

'Ergosterol irradiated'

Ergosterol, irradiated

Ertron

Fortodyl

Geltabs

Geltabs Vitamin D

Haliver

Hi-deratol

Hi-Deratol

HMS1920K20

HMS2091B19

HMS502I07

HSDB 819

Hyperkil

I05-0022

IDI1_000805

Infron

Irradiated ergosta-5,7,22-trien-3.beta.-ol

Irradiated ergosta-5,7,22-trien-3beta-ol

Irradiated ergosta-5,7,22-trien-3-beta-ol

Irradiated ergosterol

LMST03010001

LMST03010014

LS-3228

MEGxm0_000466

Metadee

Mina D2

MLS001332467

MLS001332468

MolPort-001-740-057

MolPort-001-793-930

MolPort-002-526-645

MolPort-003-666-178

MolPort-006-822-629

Mulsiferol

Mykostin

NCGC00142497-01

NCGC00179579-01

NCGC00179579-02

Novovitamin-D

NSC 62792

NSC62792

Oleovitamin D

Oleovitamin D, Synthetic

Oleovitamin D2

Osteil

Ostelin

Prestwick_554

Prestwick3_000420

Radiostol

Radstein

Radsterin

Rodine C

Rodinec

Shock-ferol

Shock-ferol sterogyl

SMR000857106

Sorex C.R

Sorex C.R.

SPECTRUM1500276

Spectrum5_000666

ST057150

Sterogyl

STOCK1N-53397

Synthetic vitamin D

Synthetic Vitamin D

UNII-VS041H42XC

Uvesterol D

Uvesterol-D

Vigantol

vio D

vio-D

Vio-D

Viostdrol

Viosterol

Viosterol in oil

Viosterol in Oil

Vitamin D 2

vitamin d-2

Vitamin D2

Vitamin- D2

VITAMIN D2

VITAMIN D2 WATER DISPERSABLE U.S.P.

Vitamin-?D2

VITAMIN_D2

Vitamina D2

Vitavel-D

WLN: L56 FYTJ A1 BY1&1U1Y1&Y1&1 FU2U- BL6YYTJ AU1 DQ

ZINC04474571

ZINC04629876

Trace Elements

Phase 2

Vitamins

Phase 2

Nutrients

Phase 2

Calciferol

Phase 2

Micronutrients

Phase 2

Ergocalciferols

Phase 2

Hormones

Phase 2

Calcium, Dietary

Phase 2

Vitamin D2

Phase 2

Calcium

Nutraceutical

Phase 2

7440-70-2

271

Synonyms:

Blood coagulation factor XIII

Ca(2+)

Ca2+

Calcio

Calcium

Calcium element

CALCIUM ion

Calcium, doubly charged positive ion

Calcium, elemental

Coagulation factor XIII

Elemental calcium

Factor XIII

Factor XIII a chain

Factor XIII a-chain

Factor XIII transamidase

Factor XIII, coagulation

Fibrin stabilizing factor

Fibrinase

Kalzium

Laki lorand factor

Laki-lorand factor

Stabilizing factor, fibrin

Transamidase, factor XIII

XIII, coagulation factor

Lidocaine

Approved, Vet_approved

137-58-6

3676

Synonyms:

.alpha.-(Diethylamino)-2,6-acetoxylidide

.alpha.-Diethylamino-2,6-dimethylacetanilide

.alpha.-Diethylaminoaceto-2,6-xylidide

.omega.-Diethylamino-2,6-dimethylacetanilide

137-58-6

2-(diethylamino)-2',6'-Acetoxylidide

2-(Diethylamino)-2',6'-acetoxylidide

2-(diethylamino)-N-(2,6-Dimethylphenyl)acetamide

2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide

2-2ETN-2MePhAcN

2-Diethylamino-N-(2,6-dimethylphenyl)acetamide

2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide

4-12-00-02538 (Beilstein Handbook Reference)

6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))

6108-05-0 (mono-hydrochloride, mono-hydrate)

73-78-9 (mono-hydrochloride)

AB00053581

AC-10282

AC1L1GGQ

AC1Q2Z7J

a-diethylamino-2,6-Dimethylacetanilide

After Burn Double Strength Gel

After Burn Double Strength Spray

After Burn Gel

After Burn Spray

AKOS001026768

alfa-Dietilamino-2,6-dimetilacetanilide

alfa-Dietilamino-2,6-dimetilacetanilide [Italian]

Alphacaine

alpha-diethylamino-2,6-dimethylacetanilide

alpha-diethylamino-2,6-Dimethylacetanilide

alpha-Diethylamino-2,6-dimethylacetanilide

Anestacon

Anestacon Jelly

ARONIS23855

Astrazeneca brand OF lidocaine

BIDD:GT0342

Bio-0767

Bio1_000379

Bio1_000868

Bio1_001357

Bio2_000079

Bio2_000559

BPBio1_000197

BRD-K52662033-001-02-6

BRD-K52662033-003-05-5

BRN 2215784

BSPBio_000179

BSPBio_001359

BSPBio_003004

C07073

C14H22N2O

Cappicaine

CAS-73-78-9

CDS1_000283

CHEBI:6456

CHEMBL79

CID3676

Cito optadren

CPD000058189

Cuivasil

D00358

Dalcaine

DB00281

Dentipatch

Dentipatch (TN)

DermaFlex

Diethylaminoaceto-2,6-xylidide

Dilocaine

DivK1c_000174

DivK1c_001323

Duncaine

EINECS 205-302-8

ELA-Max

EMBOLEX

Emla Cream

Esracaine

FT-0082378

Gravocain

HMS1791D21

HMS1989D21

HMS2051C21

HMS2089E15

HMS548M19

HSDB 3350

I01-2704

IDI1_000174

IDI1_033829

Isicaina

Isicaine

Jenapharm brand OF lidocanine hydrochloride

Jetocaine

KBio1_000174

KBio2_000079

KBio2_001598

KBio2_002647

KBio2_004166

KBio2_005215

KBio2_006734

KBio3_000157

KBio3_000158

KBio3_002224

KBioGR_000079

KBioGR_000599

KBioSS_000079

KBioSS_001598

L0156

L1026_SIGMA

L7757_SIGMA

Lanabiotic

L-Caine

Leostesin

Lida-Mantle

Lidocaina

Lidocaína

Lidocaina [INN-Spanish]

lidocaine

Lidocaine

LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)

Lidocaine (JP15/USP/INN)

Lidocaine (VAN)

Lidocaine [USAN:INN:JAN]

Lidocaine carbonate

Lidocaine Carbonate

Lidocaine carbonate (2:1)

Lidocaine hydrocarbonate

Lidocaine Hydrocarbonate

Lidocaine hydrochloride

Lidocaine monoacetate

Lidocaine monohydrochloride

Lidocaine Monohydrochloride

Lidocaine monohydrochloride, monohydrate

Lidocaine sulfate (1:1)

Lidocainum

Lidocainum [INN-Latin]

Lidocaton

Lidoderm

Lidoject-1

Lidoject-2

LIDOPEN

Lignocaine

Lignocainum

Lingocaine

Lopac0_000669

Lopac-L-5647

LQZ

LS-805

Maricaine

Maybridge1_002571

MLS000069724

MLS000758263

MLS001074177

MolPort-001-783-478

N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide

N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide

NCGC00015611-01

NCGC00015611-02

NCGC00015611-03

NCGC00015611-04

NCGC00015611-14

NCGC00022176-05

NCGC00022176-06

NCGC00022176-07

NCGC00022176-08

NCGC00022176-09

nchembio.65-comp16

NINDS_000174

Norwood Sunburn Spray

Novocol brand OF lidocaine hydrochloride

NSC 40030

NSC40030

Octocaine

Octocaine-100

Octocaine-50

Prestwick0_000050

Prestwick1_000050

Prestwick2_000050

Prestwick3_000050

Remicaine

Rocephin Kit

Rucaina

S1357_Selleck

SAM001247018

SMR000058189

Solarcaine aloe extra burn relief cream

Solcain

SPBio_001525

SPBio_002100

Spectrum_001118

Spectrum2_001343

Spectrum3_001392

Spectrum4_000070

Spectrum5_001549

STK552033

Strathmann brand OF lidocaine hydrochloride

UNII-98PI200987

WLN: 2N2 & 1VMR B1 F1

Xilina

Xilocaina

Xilocaina [Italian]

Xllina

Xycaine

Xylestesin

Xylesthesin

Xylocain

Xylocaine

Xylocaine (TN)

Xylocaine 5% Spinal

Xylocaine CO2

Xylocaine Dental Ointment

Xylocaine Endotracheal

Xylocaine Test Dose

Xylocaine Viscous

Xylocaine-Mpf

Xylocaine-Mpf with Glucose

Xylocard

Xylocitin

Xyloneural

Xyloneural (free base)

Xylotox

Zilactin-L

Zingo

α-diethylamino-2,6-dimethylacetanilide

Vitamin D3

Approved, Nutraceutical

67-97-0

5280795 6221

Synonyms:

()-Vitamin D3

(+)-vitamin D3

(+)-Vitamin D3

(1S,3Z)-3-[(2E)-2-[(1R,3AR,7as)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol

(3 beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol

(3b,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol

(3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol

(3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol

(3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol

(3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol

(3Β,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol

(5Z,7E)-(3S)-9,10-seco-5,7,10(19)-cholestatrien-3-ol

(5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-ol

(5Z,7E)-(3S)-9,10-Secocholesta-5,7,10(19)-trien-3-ol

1406-16-2

25(OH)D

47763_SUPELCO

57651-82-8

67-97-0

7-DEHYDROCHOLESTEROL

7-Dehydrocholesterol activated

7-Dehydrocholesterol, Activated

7-Dehydrocholesterol, irradiated

7-Dehydrocholestrol, activated

8024-19-9

8050-67-7

89193_FLUKA

9,10-Seco(5Z,7E)-5,7,10(19)-cholestatrien-3beta-ol

9,10-Seco(5Z,7E)-5,7,10(19)-cholestatrien-3-ol

9,10-Secocholesta-5(Z),7(E),10(19)-trien-3(.beta.)-ol

9,10-Secocholesta-5,7,10(19)-trien-3-beta-ol

AB1002422

AC-11697

AC1L1ECK

AC1L1M23

AC1LU7IZ

AC1NQXLN

AC1NR2UO

AC1NR2UR

AC1NR2UU

AC1NS4AJ

AC1NSHJX

AC1O5EOF

AC1O7GAV

AC1O7GQ3

AC1O8FEU

AC1O8PWJ

AC1OF2GI

AC1OF2GL

AC1OIEW5

AC1OIEWB

ACon1_001997

ACTIVATED

Activated 7-dehydrocholesterol

Arachitol

Bio-0845

bmse000507

BPBio1_000460

BSPBio_000418

BSPBio_002408

C05443

C1357_SIAL

C27H44O

C9756_SIGMA

C9774_SIAL

Calciol

CAS-67-97-0

CCRIS 5813

CCRIS 6286

CHEBI:283119

CHEBI:28940

CHEMBL1042

CHEMBL432780

cholecalciferol

Cholecalciferol

Cholecalciferol (D3)

Cholecalciferol (JP15/USP)

Cholecalciferol [USAN:BAN:JAN]

Cholecalciferol, D3

Cholecalciferols

Cholecalciferolum

CID10000117

CID10045875

CID10340013

CID10883523

CID10894379

CID11014566

CID11025493

CID11058152

CID11463269

CID1548921

CID2735

CID5280795

CID5283710

CID5283711

CID5283712

CID5353527

CID5363362

CID6221

CID6432644

CID6604201

CID6604662

CID6708595

CID6713938

CID6992015

CID6992016

CID7067439

CID7067440

CID7251172

CID7251174

CID9821465

Colecalciferol

Colecalciferol (INN)

Colecalciferolo

Colecalciferolo [DCIT]

Colecalciferolum

Colecalciferolum [INN-Latin]

Colecalcipherol

D00188

D3-Vicotrat

D3-Vigantol

DB00169

Delsterol

Delta-D

Delta-D (TN)

Deparal

Dihydrocholesterol

DivK1c_006276

Duphafral D3 1000

Ebivit

EINECS 200-673-2

EINECS 215-797-2

EPA Pesticide Chemical Code 202901

FeraCol

HMS1569E20

HMS2092M12

HSDB 820

I05-0041

Irradiated 7-dehydrocholesterol

KBio1_001220

KBio2_001643

KBio2_004211

KBio2_006779

KBio3_001628

KBioGR_001602

KBioSS_001643

LMST03020001

LMST03020219

LMST03020220

LMST03020221

LS-1570

LS-825

LT00244775

MEGxm0_000458

Micro-dee

MolPort-001-740-051

MolPort-001-785-972

MolPort-003-666-021

MolPort-004-946-964

NCGC00016301-01

NCGC00017328-01

NCGC00091072-01

NCGC00142511-01

NCGC00159331-02

NCGC00159331-04

NCGC00178668-01

NCGC00179565-01

NCGC00179565-02

NEO Dohyfral D3

NSC 375571

NSC375571

NSC-375571

Oleovitamin D3

Prestwick_63

Prestwick0_000429

Prestwick1_000429

Prestwick2_000429

Prestwick3_000429

Provitamine

Provitina

Rampage

Ricketon

SMP1_000068

SPBio_001298

SPBio_002357

SpecPlus_000180

Spectrum_001163

Spectrum2_001369

Spectrum3_000764

Spectrum4_001201

SR-05000001559

SR-05000001559-3

ST057172

TNP00266

Trivitan

UNII-1C6V77QF41

UPCMLD-DP152

UPCMLD-DP152:001

Vi-de-3-hydrosol

Vigorsan

VITAMIN D

Vitamin D 3

vitamin d-3

Vitamin D3

Vitamin D-3

Vitamin D3 emulsifiable

VITAMIN D3 POWDER

VITAMIN_D3

Vitinc Dan-Dee-3

ZINC04474460

ZINC04492874

ZINC04492875

ZINC04492876

ZINC04492878

δ-D

Insulin, Globin Zinc

insulin

Vaccines

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Vitamin D Dose-Response Study to Establish Dietary Requirements in Infants	Completed	NCT00381914	Phase 2	Vitamin D;Vitamin D;Vitamin D
2	A Comparative Study to Assess Efficacy of Intralesional MMR (Measles, Mumps, Rubella) Vaccine and Intralesional Vitamin D3 in Treatment of Warts	Not yet recruiting	NCT04428359		Measles-Mumps-Rubella Vaccine;Vit D

Search NIH Clinical Center for Hypervitaminosis D

Sources

Genetic Tests for Hypervitaminosis D

Sources

Anatomical Context for Hypervitaminosis D

MalaCards organs/tissues related to Hypervitaminosis D:

⁴⁰

Bone, Kidney, Liver, Lung, Heart, Smooth Muscle, Skin

Sources

Publications for Hypervitaminosis D

Articles related to Hypervitaminosis D:

(show top 50) (show all 344)

#	Title	Authors	PMID	Year
1	Biallelic CYP24A1 variants presenting during pregnancy: clinical and biochemical phenotypes. ⁶¹	Griffin TP...O'Shea PM	32375123	2020
2	Hypercalcemia, nephrolithiasis, and hypervitaminosis D precipitated by supplementation in a susceptible individual. ⁶¹	Haridas K...Burmeister LA	32222584	2020
3	Development and application of a LC-MS/MS assay for simultaneous analysis of 25-hydroxyvitamin-D and 3-epi-25-hydroxyvitamin-D metabolites in canine serum. ⁶¹	Hurst EA...Mellanby RJ	31958632	2020
4	Long-term hypervitaminosis D-induced hypercalcaemia treated with glucocorticoids and bisphosphonates. ⁶¹	Houghton CC...Lew SQ	32354763	2020
5	HYPERVITAMINOSIS D IN A GIANT ANTEATER (MYRMECOPHAGA TRIDACTYLA) AND A LARGE HAIRY ARMADILLO (CHAETOPHRACTUS VILLOSUS) RECEIVING A COMMERCIAL INSECTIVORE DIET. ⁶¹	Cole GC...Mellanby RJ	32212572	2020
6	Hypervitaminosis D without toxicity. ⁶¹	Rahesh J...Peiris AN	32063764	2020
7	Toxicity of Herbs, Vitamins, and Supplements. ⁶¹	Charen E...Harbord N	32147004	2020
8	Hypervitaminosis D has no positive effects on goat tuberculosis and may cause chronic renal lesions. ⁶¹	Risalde MA...Gortazar C	31690642	2019
9	Intractable hypercalcaemia during pregnancy and the postpartum secondary to pathogenic variants in CYP24A1. ⁶¹	Arnold N...Eastman CJ	31751313	2019
10	Hypercalcemia Without Hypervitaminosis D During Cholecalciferol Supplementation in Critically Ill Patients. ⁶¹	Holmes WL...Dickerson RN	31605425	2019
11	Normocalcemia in the Face of Marked Hypervitaminosis D: The Utility of Vitamin D Metabolite Profiling. ⁶¹	Griffin TP...O'Shea PM	31639673	2019
12	Hypercalcaemia due to Hypervitaminosis D in a Self-Supplementing Multiple Sclerosis Patient: A Case Report ⁶¹	Duffy E...Brassill MJ	31538442	2019
13	A randomised trial of vitamin D in acute-stage allergic bronchopulmonary aspergillosis complicating asthma. ⁶¹	Dodamani MH...Agarwal R	30561849	2019
14	Appearances of soft tissue calcification on Tc99m MDP bone scan. ⁶¹	Majeed Y...Hassan A	31000873	2019
15	Calcioic acid: In vivo detection and quantification of the terminal C24-oxidation product of 25-hydroxyvitamin D3 and related intermediates in serum of mice treated with 24,25-dihydroxyvitamin D3. ⁶¹	Kaufmann M...Jones G	30553931	2019
16	Expansive Vascular Remodeling and Increased Vascular Calcification Response to Cholecalciferol in a Murine Model of Obesity and Insulin Resistance. ⁶¹	Carmo LS...Liberman M	30580565	2019
17	Laboratory trend in vitamin D status in Ireland: Dual concerns about low and high 25OHD. ⁶¹	McKenna MJ...Kilbane MT	30296586	2019
18	Effect of molting on the concentration of plasma 25-hydroxyvitamin D in captive African penguins (Spheniscus demersus). ⁶¹	Ueda K...Matsui T	30308304	2019
19	Acute hypercalcemia and hypervitaminosis D associated with pulmonary tuberculosis in an elderly patient : A case report and review of the literature. ⁶¹	Wada T...Saijo A	31656304	2019
20	Severity of Ionized Hypercalcemia and Hypocalcemia Is Associated With Etiology in Dogs and Cats. ⁶¹	Coady M...Goggs R	31508432	2019
21	Redundancy Is of No Good; Iatrogenic Hypervitaminosis D: A Rare Case of Persistent Vomiting Due to Hypercalcemia. ⁶¹	Ghauri MI...Kumar A	30792578	2019
22	CYP24A1 mutations and hypervitaminosis D. ⁶¹	Willows J...Sayer JA	30651269	2019
23	Efficacy and Safety of 90,000 IU versus 300,000 IU Single Dose Oral Vitamin D in Nutritional Rickets: A Randomized Controlled Trial. ⁶¹	Mittal M...Sherwani P	30766814	2018
24	Open-label study of treatment with alendronate sodium plus vitamin D in men and women with osteoporosis in Thailand. ⁶¹	Songpatanasilp T...Santora AC	30400864	2018
25	Increased rates of 25-hydroxy vitamin D testing: Dissecting a modern epidemic. ⁶¹	Rodd C...Bohm E	30026017	2018
26	Multiple renal calculi due to hypercalcaemia induced by over-the-counter vitamin D intoxication. ⁶¹	Manappallil RG...Thomas AD	30131404	2018
27	Response to Long-term Vitamin D Therapy for Bone Disease in Children With Sickle Cell Disease. ⁶¹	Williams KM...Fennoy I	29668535	2018
28	Risks of the 'Sunshine pill' - a case of hypervitaminosis D. ⁶¹	Ellis S...Lad T	30072556	2018
29	Can adverse effects of excessive vitamin D supplementation occur without developing hypervitaminosis D? ⁶¹	Razzaque MS	28734988	2018
30	Soluble Klotho causes hypomineralization in Klotho-deficient mice. ⁶¹	Minamizaki T...Yoshiko Y	29632215	2018
31	SUSPECTED HYPERVITAMINOSIS D IN RED-RUMPED AGOUTI ( DASYPROCTA LEPORINA) RECEIVING A COMMERCIAL RODENT DIET. ⁶¹	Anderson KM...Dennis PM	29517453	2018
32	Acute fish liver intoxication induced blisters formation and generalized skin peeling. ⁶¹	Chang CH...Ho HC	28841060	2018
33	Hypercalcemic pancreatitis a rare presentation of sarcoidosis: A case report. ⁶¹	Gebreselassie A...Kibreab A	29480854	2018
34	Vitamin D Toxicity-A Clinical Perspective. ⁶¹	Marcinowska-Suchowierska E...Jones G	30294301	2018
35	Vitamin D deficiency: Time for a reality check of the epidemiology. Re. "The increasing problem of subclinical and overt hypervitaminosis D in India: An institutional experience and review." ⁶¹	Dhibar DP...Bhadada SK	28652074	2018
36	How much is too much? Two contrasting cases of excessive vitamin D supplementation. ⁶¹	Kim S...Fitzgerald RL	28801091	2017
37	Vitamin D in human reproduction: the more, the better? An evidence-based critical appraisal. ⁶¹	Lagana AS...D'Anna R	29028072	2017
38	Vitamin D toxicity of dietary origin in cats fed a natural complementary kitten food. ⁶¹	Crossley VJ...Finch NC	29270305	2017
39	Bi-allelic IARS mutations in a child with intra-uterine growth retardation, neonatal cholestasis, and mild developmental delay. ⁶¹	Orenstein N...Muenke M	27891590	2017
40	The increasing problem of subclinical and overt hypervitaminosis D in India: An institutional experience and review. ⁶¹	Sharma LK...Gadpayle AK	28063517	2017
41	Hypervitaminosis D Associated With Tanning Bed Use: A Case Report. ⁶¹	Laurent MR...Bouillon R	28114469	2017
42	Prevalence of hypercalcemia related to hypervitaminosis D in clinical practice. ⁶¹	Perez-Barrios C...Granado-Lorencio F	26995293	2016
43	Reduction of serum 25-hydroxyvitamin D concentrations with intravenous lipid emulsion in a dog. ⁶¹	Perry BH...Jewell E	27928177	2016
44	Influence hypervitaminosis D3 on hemodynamic presentation of experimental copper intoxication. ⁶¹	Brin VB...Kabisov OT	29244912	2016
45	Effect of intramuscular cholecalciferol megadose in children with nutritional rickets. ⁶¹	Bothra M...Jain V	26913455	2016
46	Hypervitaminosis D with Dyslipidemia: An Unusual Scenario. ⁶¹	Sharawat IK	26897163	2016
47	Reversible vascular calcifications associated with hypervitaminosis D. ⁶¹	Cirillo M...Cirillo C	26318020	2016
48	[Hypervitaminosis D due to a dietary supplement]. ⁶¹	Zigenhorn M...Rietveld AP	27071359	2016
49	A 23-year-old patient with secondary tumoral calcinosis: Regression after subtotal parathyroidectomy: A case report. ⁶¹	Niemann KE...Schildhauer TA	27088846	2016
50	Dystrophic mineralization of the arterial fibrovascular tissue associated with a vitamin D hypervitaminosis in an 8-year-old female Alpaca (Vicugna pacos). ⁶¹	Tavella A...Zanolari P	28018578	2016

Sources

Genes for Hypervitaminosis D

Genes related to Hypervitaminosis D (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PTH	Parathyroid Hormone	Protein Coding	14.07	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	KL	Klotho	Protein Coding	7.78	DISEASES inferred ¹⁵
3	FGF23	Fibroblast Growth Factor 23	Protein Coding	7.7	DISEASES inferred ¹⁵
4	TRPV5	Transient Receptor Potential Cation Channel Subfamily V Member 5	Protein Coding	7.24	DISEASES inferred ¹⁵
5	CYP27B1	Cytochrome P450 Family 27 Subfamily B Member 1	Protein Coding	7.04	DISEASES inferred ¹⁵
6	VDR	Vitamin D Receptor	Protein Coding	6.93	DISEASES inferred ¹⁵
7	CYP24A1	Cytochrome P450 Family 24 Subfamily A Member 1	Protein Coding	6.87	DISEASES inferred ¹⁵
8	GALNT3	Polypeptide N-Acetylgalactosaminyltransferase 3	Protein Coding	6.38	DISEASES inferred ¹⁵
9	GC	GC Vitamin D Binding Protein	Protein Coding	6.22	DISEASES inferred ¹⁵
10	TRPV6	Transient Receptor Potential Cation Channel Subfamily V Member 6	Protein Coding	6.16	DISEASES inferred ¹⁵
11	PDLIM1	PDZ And LIM Domain 1	Protein Coding	6.09	DISEASES inferred ¹⁵
12	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	6.06	DISEASES inferred ¹⁵
13	PTHLH	Parathyroid Hormone Like Hormone	Protein Coding	6.04	DISEASES inferred ¹⁵
14	CYP2R1	Cytochrome P450 Family 2 Subfamily R Member 1	Protein Coding	5.92	DISEASES inferred ¹⁵

Sources

Variations for Hypervitaminosis D

Sources

Expression for Hypervitaminosis D

Search GEO for disease gene expression data for Hypervitaminosis D.

Sources

Pathways for Hypervitaminosis D

Pathways related to Hypervitaminosis D according to GeneCards Suite gene sharing:

(show all 13)

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism of water-soluble vitamins and cofactors ⁶⁵ Show member pathways [2Fe-2S] iron-sulfur cluster biosynthesis ¹ Biotin transport and metabolism ⁶⁵ biotin-carboxyl carrier protein assembly ¹ coenzyme A biosynthesis ¹ Coenzyme A biosynthesis ⁶⁵ flavin biosynthesis ¹ folate polyglutamylation ¹ glycine/serine biosynthesis ¹ Metabolism of folate and pterines ⁶⁵ Metabolism of vitamins and cofactors ⁶⁵ molybdenum cofactor biosynthesis ¹ Molybdenum cofactor biosynthesis ⁶⁵ thiamin salvage III ¹ thio-molybdenum cofactor biosynthesis ¹ Vitamin B1 (thiamin) metabolism ⁶⁵ Vitamin B2 (riboflavin) metabolism ⁶⁵ Vitamin B5 (pantothenate) metabolism ⁶⁵ Vitamin C (ascorbate) metabolism ⁶⁵ Vitamins B6 activation to pyridoxal phosphate ⁶⁵	12.38	GC CYP2R1 CYP27B1 CYP24A1
2	Metabolism of fat-soluble vitamins ⁶⁵ Show member pathways Metabolism of vitamin K ⁶⁵ Retinoid metabolism and transport ⁶⁵ The retinoid cycle in cones (daylight vision) ⁶⁵ Visual phototransduction ⁶⁵ Vitamin D (calciferol) metabolism ⁶⁵	12.04	GC CYP2R1 CYP27B1 CYP24A1
3	Signaling by FGFR2 ⁶⁵ Show member pathways FGFR2 ligand binding and activation ⁶⁵ FGFR2b ligand binding and activation ⁶⁵ Signaling by FGFR ⁶⁵	11.99	KL GALNT3 FGF23
4	G alpha (s) signalling events ⁶⁵	11.84	PTHLH PTH CALCA
5	Parathyroid hormone synthesis, secretion and action ³⁶	11.58	VDR TRPV5 PTHLH PTH KL FGF23
6	cholesterol biosynthesis III (via desmosterol) ¹ Show member pathways cholesterol biosynthesis I ¹ cholesterol biosynthesis II (via 24,25-dihydrolanosterol) ¹ Cholesterol biosynthesis via desmosterol ⁶⁵ Cholesterol biosynthesis via lathosterol ⁶⁵ epoxysqualene biosynthesis ¹ lanosterol biosynthesis ¹ Steroid biosynthesis ³⁶ zymosterol biosynthesis ¹	11.49	CYP2R1 CYP27B1 CYP24A1
7	Endocrine and other factor-regulated calcium reabsorption ³⁶	11.28	VDR TRPV5 PTH KL
8	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.21	VDR PTH CYP27B1 CYP24A1 CALCA
9	Development_Hedgehog and PTH signaling pathways in bone and cartilage development ²²	11.14	VDR PTHLH PTH
10	Nuclear Receptors in Lipid Metabolism and Toxicity ¹	11.04	VDR CYP27B1 CYP24A1
11	TRP channels ⁶⁵	10.91	TRPV6 TRPV5
12	Osteoblast Signaling ¹	10.6	PTH FGF23
13	Vitamin D Metabolism ¹	10.1	VDR PTH GC CYP2R1 CYP27B1 CYP24A1

Sources

GO Terms for Hypervitaminosis D

Biological processes related to Hypervitaminosis D according to GeneCards Suite gene sharing:

(show all 22)

#	Name	GO ID	Score	Top Affiliating Genes
1	skeletal system development	GO:0001501	9.77	VDR PTHLH PTH
2	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GO:0007189	9.74	PTHLH PTH CALCA
3	calcium ion transport	GO:0006816	9.73	VDR TRPV6 TRPV5 CYP27B1
4	cellular calcium ion homeostasis	GO:0006874	9.72	VDR PTH CALCA
5	fibroblast growth factor receptor signaling pathway	GO:0008543	9.71	KL GALNT3 FGF23
6	decidualization	GO:0046697	9.61	VDR CYP27B1
7	regulation of bone mineralization	GO:0030500	9.59	FGF23 CYP27B1
8	negative regulation of chondrocyte differentiation	GO:0032331	9.58	PTHLH PTH
9	positive regulation of keratinocyte differentiation	GO:0045618	9.58	VDR CYP27B1
10	calcium ion import across plasma membrane	GO:0098703	9.56	TRPV6 TRPV5
11	response to vitamin D	GO:0033280	9.54	PTH CYP27B1 CYP24A1
12	phosphate ion homeostasis	GO:0055062	9.52	PTH FGF23
13	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	GO:0090080	9.51	KL FGF23
14	vitamin metabolic process	GO:0006766	9.5	CYP2R1 CYP27B1 CYP24A1
15	calcitriol biosynthetic process from calciol	GO:0036378	9.49	CYP2R1 CYP27B1
16	vitamin D receptor signaling pathway	GO:0070561	9.48	VDR CYP24A1
17	cAMP metabolic process	GO:0046058	9.46	PTHLH PTH
18	vitamin D catabolic process	GO:0042369	9.43	FGF23 CYP27B1 CYP24A1
19	vitamin D biosynthetic process	GO:0042368	9.4	CYP2R1 CYP27B1
20	calcium ion homeostasis	GO:0055074	9.35	TRPV6 TRPV5 PTH KL CYP27B1
21	positive regulation of vitamin D 24-hydroxylase activity	GO:0010980	9.33	VDR FGF23 CYP27B1
22	vitamin D metabolic process	GO:0042359	9.1	VDR GC FGF23 CYP2R1 CYP27B1 CYP24A1

Molecular functions related to Hypervitaminosis D according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	heme binding	GO:0020037	9.58	CYP2R1 CYP27B1 CYP24A1
2	iron ion binding	GO:0005506	9.54	CYP2R1 CYP27B1 CYP24A1
3	monooxygenase activity	GO:0004497	9.5	CYP2R1 CYP27B1 CYP24A1
4	fibroblast growth factor receptor binding	GO:0005104	9.43	KL FGF23
5	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0016705	9.33	CYP2R1 CYP27B1 CYP24A1
6	peptide hormone receptor binding	GO:0051428	9.26	PTHLH PTH
7	hormone activity	GO:0005179	9.26	PTHLH PTH KL CALCA
8	vitamin D binding	GO:0005499	8.8	VDR KL GC

Sources

Sources for Hypervitaminosis D

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia