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MCID: HYP057
MIFTS: 41

Hypervitaminosis D

Categories: Metabolic diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Hypervitaminosis D

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MalaCards integrated aliases for Hypervitaminosis D:

Name: Hypervitaminosis D 12 75 15 72 33

Classifications:

MalaCards categories:
Global: Metabolic diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:9971
ICD9CM 35 278.4
SNOMED-CT 68 27712000
ICD10 33 E67.3
UMLS 72 C1442839
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Summaries for Hypervitaminosis D

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Disease Ontology : 12 An overnutrition that is characterized by elevated vitamin D, which can subsequently cause high levels of calcium, has symptom myalgia, fatigue, irritability, nausea, dehydration, polyuria, and nephrocalcinosis, and possibly has material basis in excess intake of vitamin D.

MalaCards based summary : Hypervitaminosis D is related to calcinosis and bone resorption disease, and has symptoms including myalgia An important gene associated with Hypervitaminosis D is PTH (Parathyroid Hormone), and among its related pathways/superpathways are cholesterol biosynthesis I and Endocrine and other factor-regulated calcium reabsorption. The drugs Ergocalciferol and Vitamin D have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and liver, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 75 Hypervitaminosis D is a state of vitamin D toxicity. The normal range for blood concentration is 30.0 to... more...

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Related Diseases for Hypervitaminosis D

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Diseases in the Hypervitaminosis a family:

Hypervitaminosis D

Diseases related to Hypervitaminosis D via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 calcinosis 30.7 KL FGF23
2 bone resorption disease 30.2 VDR PTH
3 hypophosphatemia 30.0 PTH FGF23
4 hypoparathyroidism 29.9 PTH FGF23
5 renal osteodystrophy 29.6 VDR PTH FGF23
6 hypocalcemia, autosomal dominant 1 29.6 VDR PTH FGF23
7 rickets 29.5 VDR PTH FGF23 CYP27B1
8 hyperparathyroidism 29.3 VDR PTH FGF23 CYP27B1
9 kidney disease 29.2 VDR PTH FGF23
10 hyperphosphatemia 28.9 VDR PTH KL FGF23
11 osteoporosis 28.0 VDR PTH KL FGF23 CYP27B1
12 arterial calcification of infancy 11.4
13 nephrocalcinosis 10.3
14 oncogenic osteomalacia 10.2 PTH FGF23
15 impaired renal function disease 10.2 PTH FGF23
16 pulmonary alveolar microlithiasis 10.2 PTH FGF23
17 metaphyseal chondrodysplasia, jansen type 10.2 PTH FGF23
18 arteriosclerosis 10.2
19 tracheal calcification 10.1 KL FGF23
20 familial tumoral calcinosis 10.1 KL FGF23
21 diabetes insipidus, nephrogenic, autosomal 10.1
22 endosteal hyperostosis, autosomal dominant 10.1
23 diabetes insipidus 10.1
24 premature aging 10.1
25 idiopathic hypercalciuria 10.1 VDR TRPV5
26 tumoral calcinosis, hyperphosphatemic, familial, 1 10.0 KL FGF23
27 parathyroid adenoma 10.0 VDR PTH
28 vitamin d-dependent rickets, type 2a 10.0 VDR CYP27B1
29 atherosclerosis susceptibility 9.9
30 alagille syndrome 1 9.9
31 neurofibromatosis, type iv, of riccardi 9.9
32 rheumatoid arthritis 9.9
33 sarcoidosis 1 9.9
34 williams-beuren syndrome 9.9
35 cystic fibrosis 9.9
36 hypervitaminosis a 9.9
37 intracranial hypertension, idiopathic 9.9
38 branchiootic syndrome 1 9.9
39 bone mineral density quantitative trait locus 8 9.9
40 bone mineral density quantitative trait locus 15 9.9
41 extrapulmonary tuberculosis 9.9
42 osteonecrosis 9.9
43 fanconi syndrome 9.9
44 pneumocystosis 9.9
45 infant gynecomastia 9.9
46 nephrosclerosis 9.9
47 secondary hyperparathyroidism 9.9
48 gynecomastia 9.9
49 osteopetrosis 9.9
50 constipation 9.9

Graphical network of the top 20 diseases related to Hypervitaminosis D:



Diseases related to Hypervitaminosis D
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Symptoms & Phenotypes for Hypervitaminosis D

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Symptoms:

12
  • • myalgia

MGI Mouse Phenotypes related to Hypervitaminosis D:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.98 CYP24A1 CYP27B1 FGF23 KL PTH TRPV5
2 homeostasis/metabolism MP:0005376 9.91 CYP24A1 CYP27B1 FGF23 KL PTH TRPV5
3 hematopoietic system MP:0005397 9.88 CYP27B1 FGF23 KL PTH TRPV5 VDR
4 endocrine/exocrine gland MP:0005379 9.85 CYP27B1 FGF23 KL PTH VDR
5 cardiovascular system MP:0005385 9.81 FGF23 KL PTH VDR
6 craniofacial MP:0005382 9.8 CYP27B1 KL PTH VDR
7 immune system MP:0005387 9.8 CYP27B1 FGF23 KL PTH TRPV5 VDR
8 digestive/alimentary MP:0005381 9.78 FGF23 KL TRPV5 VDR
9 limbs/digits/tail MP:0005371 9.65 CYP27B1 FGF23 KL PTH VDR
10 renal/urinary system MP:0005367 9.63 CYP24A1 CYP27B1 FGF23 KL TRPV5 VDR
11 reproductive system MP:0005389 9.35 CYP24A1 CYP27B1 FGF23 KL VDR
12 skeleton MP:0005390 9.17 CYP24A1 CYP27B1 FGF23 KL PTH TRPV5
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Drugs & Therapeutics for Hypervitaminosis D

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Drugs for Hypervitaminosis D (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ergocalciferol Approved, Nutraceutical Phase 2 50-14-6 5280793
2
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2 1406-16-2
3
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
4 Micronutrients Phase 2
5 Trace Elements Phase 2
6 Hormones Phase 2
7 Vitamins Phase 2
8 Nutrients Phase 2
9 Ergocalciferols Phase 2
10 Vitamin D2 Phase 2
11 Calciferol Phase 2
12 Calcium, Dietary Phase 2
13 Bone Density Conservation Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vitamin D Dose-Response Study to Establish Dietary Requirements in Infants Completed NCT00381914 Phase 2 Vitamin D;Vitamin D;Vitamin D

Search NIH Clinical Center for Hypervitaminosis D

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Genetic Tests for Hypervitaminosis D

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Anatomical Context for Hypervitaminosis D

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MalaCards organs/tissues related to Hypervitaminosis D:

41
Bone, Kidney, Liver, Lung, Heart, Skin, Smooth Muscle
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Publications for Hypervitaminosis D

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Articles related to Hypervitaminosis D:

(show top 50) (show all 330)
# Title Authors PMID Year
1
A randomised trial of vitamin D in acute-stage allergic bronchopulmonary aspergillosis complicating asthma. 38
30561849 2019
2
Appearances of soft tissue calcification on Tc99m MDP bone scan. 38
31000873 2019
3
Calcioic acid: In vivo detection and quantification of the terminal C24-oxidation product of 25-hydroxyvitamin D3 and related intermediates in serum of mice treated with 24,25-dihydroxyvitamin D3. 38
30553931 2019
4
Laboratory trend in vitamin D status in Ireland: Dual concerns about low and high 25OHD. 38
30296586 2019
5
Expansive Vascular Remodeling and Increased Vascular Calcification Response to Cholecalciferol in a Murine Model of Obesity and Insulin Resistance. 38
30580565 2019
6
CYP24A1 mutations and hypervitaminosis D. 38
30651269 2019
7
Redundancy Is of No Good; Iatrogenic Hypervitaminosis D: A Rare Case of Persistent Vomiting Due to Hypercalcemia. 38
30792578 2019
8
Effect of molting on the concentration of plasma 25-hydroxyvitamin D in captive African penguins (Spheniscus demersus). 38
30308304 2019
9
Open-label study of treatment with alendronate sodium plus vitamin D in men and women with osteoporosis in Thailand. 38
30400864 2018
10
Efficacy and Safety of 90,000 IU versus 300,000 IU Single Dose Oral Vitamin D in Nutritional Rickets: A Randomized Controlled Trial. 38
30766814 2018
11
Increased rates of 25-hydroxy vitamin D testing: Dissecting a modern epidemic. 38
30026017 2018
12
Multiple renal calculi due to hypercalcaemia induced by over-the-counter vitamin D intoxication. 38
30131404 2018
13
Response to Long-term Vitamin D Therapy for Bone Disease in Children With Sickle Cell Disease. 38
29668535 2018
14
Risks of the 'Sunshine pill' - a case of hypervitaminosis D. 38
30072556 2018
15
Can adverse effects of excessive vitamin D supplementation occur without developing hypervitaminosis D? 38
28734988 2018
16
Soluble Klotho causes hypomineralization in Klotho-deficient mice. 38
29632215 2018
17
SUSPECTED HYPERVITAMINOSIS D IN RED-RUMPED AGOUTI ( DASYPROCTA LEPORINA) RECEIVING A COMMERCIAL RODENT DIET. 38
29517453 2018
18
Acute fish liver intoxication induced blisters formation and generalized skin peeling. 38
28841060 2018
19
Vitamin D Toxicity-A Clinical Perspective. 38
30294301 2018
20
Hypercalcemic pancreatitis a rare presentation of sarcoidosis: A case report. 38
29480854 2018
21
Vitamin D deficiency: Time for a reality check of the epidemiology. Re. "The increasing problem of subclinical and overt hypervitaminosis D in India: An institutional experience and review." 38
28652074 2018
22
How much is too much? Two contrasting cases of excessive vitamin D supplementation. 38
28801091 2017
23
Vitamin D in human reproduction: the more, the better? An evidence-based critical appraisal. 38
29028072 2017
24
Vitamin D toxicity of dietary origin in cats fed a natural complementary kitten food. 38
29270305 2017
25
Bi-allelic IARS mutations in a child with intra-uterine growth retardation, neonatal cholestasis, and mild developmental delay. 38
27891590 2017
26
The increasing problem of subclinical and overt hypervitaminosis D in India: An institutional experience and review. 38
28063517 2017
27
Hypervitaminosis D Associated With Tanning Bed Use: A Case Report. 38
28114469 2017
28
Prevalence of hypercalcemia related to hypervitaminosis D in clinical practice. 38
26995293 2016
29
Reduction of serum 25-hydroxyvitamin D concentrations with intravenous lipid emulsion in a dog. 38
27928177 2016
30
Influence hypervitaminosis D3 on hemodynamic presentation of experimental copper intoxication. 38
29244912 2016
31
Effect of intramuscular cholecalciferol megadose in children with nutritional rickets. 38
26913455 2016
32
Hypervitaminosis D with Dyslipidemia: An Unusual Scenario. 38
26897163 2016
33
Reversible vascular calcifications associated with hypervitaminosis D. 38
26318020 2016
34
[Hypervitaminosis D due to a dietary supplement]. 38
27071359 2016
35
A 23-year-old patient with secondary tumoral calcinosis: Regression after subtotal parathyroidectomy: A case report. 38
27088846 2016
36
Dystrophic mineralization of the arterial fibrovascular tissue associated with a vitamin D hypervitaminosis in an 8-year-old female Alpaca (Vicugna pacos). 38
28018578 2016
37
[Nephrocalcinosis in children]. 38
29710439 2015
38
Phenytoin Induced Osteopathy -Too Common to be Neglected. 38
26674262 2015
39
Unmasking of primary hyperparathyroidism by Vitamin D therapy. 38
26664216 2015
40
Acute Hypercalcaemia and Hypervitaminosis D in an Infant with Extra Pulmonary Tuberculosis. 38
26557587 2015
41
Rising trend in vitamin D status from 1993 to 2013: dual concerns for the future. 38
26034120 2015
42
Hypervitaminosis D and Metastatic Calcification in a Colony of Inbred Strain 13 Guinea Pigs, Cavia porcellus. 38
25281651 2015
43
Clinical investigation into feed-related hypervitaminosis D in a captive flock of budgerigars (Melopsittacus undulatus): morbidity, mortalities, and pathologic lesions. 38
25831571 2015
44
A nontoxic case of vitamin D toxicity. 38
25918194 2015
45
Biochemical parameters after cholecalciferol repletion in hemodialysis: results From the VitaDial randomized trial. 38
24856872 2014
46
Hypervitaminosis-D, an uncommon reality! 38
25906526 2014
47
The double-edged sword of vitamin D in Ireland: the need for public health awareness about too much as well as too little. 38
24859288 2014
48
Vitamin D intoxication in two brothers: be careful with dietary supplements. 38
24670344 2014
49
Tanning beds and hypervitaminosis D: a case report. 38
24887628 2014
50
300,000 IU or 600,000 IU of oral vitamin D3 for treatment of nutritional rickets: a randomized controlled trial. 38
24825262 2014
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Variations for Hypervitaminosis D

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Expression for Hypervitaminosis D

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Search GEO for disease gene expression data for Hypervitaminosis D.
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Pathways for Hypervitaminosis D

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Pathways related to Hypervitaminosis D according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
cholesterol biosynthesis I 1
Show member pathways
 11.31 CYP27B1 CYP24A1
2
Endocrine and other factor-regulated calcium reabsorption 37
11.2 VDR TRPV5 KL
3
Parathyroid hormone synthesis, secretion and action 37
11.19 VDR TRPV5 PTH KL FGF23 CYP27B1
4
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.11 VDR PTH CYP27B1 CYP24A1
5
Development_Hedgehog and PTH signaling pathways in bone and cartilage development 22
11 VDR PTH
6
Nuclear Receptors in Lipid Metabolism and Toxicity 1
10.98 VDR CYP27B1 CYP24A1
7
Osteoblast Signaling 1
10.51 PTH FGF23
8
Vitamin D Metabolism 1
10.26 VDR PTH CYP27B1 CYP24A1
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GO Terms for Hypervitaminosis D

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Biological processes related to Hypervitaminosis D according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cellular calcium ion homeostasis GO:0006874 9.57 VDR PTH
2 fibroblast growth factor receptor signaling pathway GO:0008543 9.56 KL FGF23
3 positive regulation of bone mineralization GO:0030501 9.54 PTH KL
4 calcium ion homeostasis GO:0055074 9.54 TRPV5 KL CYP27B1
5 decidualization GO:0046697 9.52 VDR CYP27B1
6 regulation of bone mineralization GO:0030500 9.51 FGF23 CYP27B1
7 calcium ion transport GO:0006816 9.5 VDR TRPV5 CYP27B1
8 positive regulation of keratinocyte differentiation GO:0045618 9.49 VDR CYP27B1
9 vitamin metabolic process GO:0006766 9.48 CYP27B1 CYP24A1
10 phosphate ion homeostasis GO:0055062 9.46 PTH FGF23
11 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 9.43 KL FGF23
12 response to vitamin D GO:0033280 9.43 PTH CYP27B1 CYP24A1
13 vitamin D receptor signaling pathway GO:0070561 9.4 VDR CYP24A1
14 vitamin D catabolic process GO:0042369 9.33 FGF23 CYP27B1 CYP24A1
15 bone mineralization GO:0030282 9.25 CYP27B1
16 positive regulation of vitamin D 24-hydroxylase activity GO:0010980 9.13 VDR FGF23 CYP27B1
17 vitamin D metabolic process GO:0042359 8.92 VDR FGF23 CYP27B1 CYP24A1

Molecular functions related to Hypervitaminosis D according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.16 CYP27B1 CYP24A1
2 fibroblast growth factor receptor binding GO:0005104 8.96 KL FGF23
3 vitamin D binding GO:0005499 8.62 VDR KL
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Sources for Hypervitaminosis D

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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