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MCID: HYP057
MIFTS: 41

Hypervitaminosis D

Categories: Metabolic diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Hypervitaminosis D

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MalaCards integrated aliases for Hypervitaminosis D:

Name: Hypervitaminosis D 12 74 15 71 32

Classifications:

MalaCards categories:
Global: Metabolic diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:9971
ICD9CM 34 278.4
SNOMED-CT 67 27712000
ICD10 32 E67.3
UMLS 71 C1442839
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Summaries for Hypervitaminosis D

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Disease Ontology : 12 An overnutrition that is characterized by elevated vitamin D, which can subsequently cause high levels of calcium, has symptom myalgia, fatigue, irritability, nausea, dehydration, polyuria, and nephrocalcinosis, and possibly has material basis in excess intake of vitamin D.

MalaCards based summary : Hypervitaminosis D is related to arterial calcification of infancy and nephrocalcinosis, and has symptoms including myalgia An important gene associated with Hypervitaminosis D is PTH (Parathyroid Hormone), and among its related pathways/superpathways are Metabolism of fat-soluble vitamins and Signaling by FGFR2. The drugs Ergocalciferol and Vitamin D have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and liver, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 74 Hypervitaminosis D is a state of vitamin D toxicity. The normal range for blood concentration is 30.0 to... more...

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Related Diseases for Hypervitaminosis D

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Diseases in the Hypervitaminosis a family:

Hypervitaminosis D

Diseases related to Hypervitaminosis D via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
# Related Disease Score Top Affiliating Genes
1 arterial calcification of infancy 32.2 KL GALNT3 FGF23
2 nephrocalcinosis 30.3 TRPV5 PTH FGF23 CYP24A1
3 calcinosis 29.8 PTH KL GALNT3 FGF23 CALCA
4 renal osteodystrophy 29.6 VDR PTH FGF23 CALCA
5 hyperphosphatemia 29.4 VDR PTH KL GALNT3 FGF23
6 rickets 29.2 VDR PTH KL GC FGF23 CYP27B1
7 hypoparathyroidism 28.9 VDR PTHLH PTH FGF23 CALCA
8 bone resorption disease 28.6 VDR PTHLH PTH KL FGF23 CALCA
9 hypophosphatemia 28.6 VDR PTHLH PTH KL FGF23 CYP27B1
10 hypocalcemia, autosomal dominant 1 28.3 VDR PTHLH PTH FGF23 CYP27B1 CALCA
11 secondary hyperparathyroidism 27.9 VDR PTH KL GC FGF23 CYP27B1
12 hyperparathyroidism 27.3 VDR TRPV6 PTHLH PTH KL GC
13 osteoporosis 27.0 VDR PTHLH PTH KL GC FGF23
14 bone benign neoplasm 10.3 PTH FGF23
15 hyperlipoproteinemia, type v 10.3 KL FGF23
16 idiopathic hypercalciuria 10.3 VDR TRPV5
17 vitamin d-dependent rickets, type 2a 10.3 VDR CYP27B1
18 tuberculous epididymitis 10.3 VDR CYP27B1
19 dental pulp calcification 10.3 KL GALNT3
20 enthesopathy 10.2 GALNT3 FGF23
21 tracheal calcification 10.2 PTH KL FGF23
22 colon sarcoma 10.2 CYP27B1 CYP24A1
23 impaired renal function disease 10.2 PTH KL FGF23
24 ossifying fibroma 10.2 PTH FGF23
25 calciphylaxis 10.2 VDR PTH FGF23
26 endemic goiter 10.2 PTH CALCA
27 arteriosclerosis 10.2
28 pulmonary alveolar microlithiasis 10.2 GALNT3 FGF23
29 spondylosis 10.2 VDR PTH KL
30 nontoxic goiter 10.2 PTH CALCA
31 aromatase deficiency 10.2 TRPV6 TRPV5
32 giant cell reparative granuloma 10.1 PTH CALCA
33 hypophosphatemic rickets with hypercalciuria, hereditary 10.1 PTH GALNT3 FGF23
34 conjunctival deposit 10.1 KL GALNT3 FGF23
35 familial tumoral calcinosis 10.1 KL GALNT3 FGF23
36 graves disease 1 10.1 PTH CALCA
37 diabetes insipidus, nephrogenic, autosomal 10.1
38 endosteal hyperostosis, autosomal dominant 10.1
39 pulmonary tuberculosis 10.1
40 diabetes insipidus 10.1
41 premature aging 10.1
42 nerve compression syndrome 10.1 PTH CALCA
43 hyperostosis 10.1 KL GALNT3 FGF23
44 lactose intolerance 10.1 VDR PTH
45 idiopathic infantile hypercalcemia 10.0 PDLIM1 CYP24A1
46 osteitis fibrosa 10.0 PTH FGF23 CALCA
47 pediatric ovarian germ cell tumor 10.0 PTHLH PTH
48 pediatric ovarian dysgerminoma 10.0 PTHLH PTH
49 glucocorticoid-induced osteoporosis 10.0 VDR PTH CALCA
50 paraneoplastic syndromes 10.0 PTHLH FGF23

Graphical network of the top 20 diseases related to Hypervitaminosis D:



Diseases related to Hypervitaminosis D
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Symptoms & Phenotypes for Hypervitaminosis D

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Symptoms:

12
  • • myalgia

MGI Mouse Phenotypes related to Hypervitaminosis D:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.13 CYP24A1 CYP27B1 FGF23 GALNT3 KL PTH
2 homeostasis/metabolism MP:0005376 10.07 CYP24A1 CYP27B1 FGF23 GALNT3 GC KL
3 endocrine/exocrine gland MP:0005379 10.06 CYP27B1 FGF23 GALNT3 GC KL PTH
4 hematopoietic system MP:0005397 10.06 CYP27B1 FGF23 GALNT3 KL PDLIM1 PTH
5 craniofacial MP:0005382 9.97 CYP27B1 GALNT3 KL PTH PTHLH VDR
6 immune system MP:0005387 9.97 CYP27B1 FGF23 GALNT3 KL PDLIM1 PTH
7 digestive/alimentary MP:0005381 9.95 FGF23 GALNT3 KL PTHLH TRPV5 VDR
8 limbs/digits/tail MP:0005371 9.8 CYP27B1 FGF23 GALNT3 KL PTH PTHLH
9 renal/urinary system MP:0005367 9.76 CYP24A1 CYP27B1 FGF23 GALNT3 KL PTHLH
10 reproductive system MP:0005389 9.56 CYP24A1 CYP27B1 FGF23 GALNT3 KL PTHLH
11 skeleton MP:0005390 9.32 CYP24A1 CYP27B1 FGF23 GALNT3 GC KL
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Drugs & Therapeutics for Hypervitaminosis D

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Drugs for Hypervitaminosis D (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ergocalciferol Approved, Nutraceutical Phase 2 50-14-6 5280793
2
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2 1406-16-2
3
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
4 Trace Elements Phase 2
5 Vitamins Phase 2
6 Micronutrients Phase 2
7 Nutrients Phase 2
8 Ergocalciferols Phase 2
9 Vitamin D2 Phase 2
10 Calciferol Phase 2
11 Calcium, Dietary Phase 2
12 Hormones Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vitamin D Dose-Response Study to Establish Dietary Requirements in Infants Completed NCT00381914 Phase 2 Vitamin D;Vitamin D;Vitamin D

Search NIH Clinical Center for Hypervitaminosis D

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Genetic Tests for Hypervitaminosis D

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Anatomical Context for Hypervitaminosis D

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MalaCards organs/tissues related to Hypervitaminosis D:

40
Bone, Kidney, Liver, Lung, Heart, Smooth Muscle, Skin
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Publications for Hypervitaminosis D

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Articles related to Hypervitaminosis D:

(show top 50) (show all 337)
# Title Authors PMID Year
1
Intractable hypercalcaemia during pregnancy and the postpartum secondary to pathogenic variants in CYP24A1. 61
31751313 2019
2
Hypervitaminosis D has no positive effects on goat tuberculosis and may cause chronic renal lesions. 61
31690642 2019
3
Hypercalcemia Without Hypervitaminosis D During Cholecalciferol Supplementation in Critically Ill Patients. 61
31605425 2019
4
Normocalcemia in the Face of Marked Hypervitaminosis D: The Utility of Vitamin D Metabolite Profiling. 61
31639673 2019
5
Hypercalcaemia due to Hypervitaminosis D in a Self-Supplementing Multiple Sclerosis Patient: A Case Report 61
31538442 2019
6
A randomised trial of vitamin D in acute-stage allergic bronchopulmonary aspergillosis complicating asthma. 61
30561849 2019
7
Appearances of soft tissue calcification on Tc99m MDP bone scan. 61
31000873 2019
8
Calcioic acid: In vivo detection and quantification of the terminal C24-oxidation product of 25-hydroxyvitamin D3 and related intermediates in serum of mice treated with 24,25-dihydroxyvitamin D3. 61
30553931 2019
9
Laboratory trend in vitamin D status in Ireland: Dual concerns about low and high 25OHD. 61
30296586 2019
10
Expansive Vascular Remodeling and Increased Vascular Calcification Response to Cholecalciferol in a Murine Model of Obesity and Insulin Resistance. 61
30580565 2019
11
Severity of Ionized Hypercalcemia and Hypocalcemia Is Associated With Etiology in Dogs and Cats. 61
31508432 2019
12
Acute hypercalcemia and hypervitaminosis D associated with pulmonary tuberculosis in an elderly patient : A case report and review of the literature. 61
31656304 2019
13
Redundancy Is of No Good; Iatrogenic Hypervitaminosis D: A Rare Case of Persistent Vomiting Due to Hypercalcemia. 61
30792578 2019
14
CYP24A1 mutations and hypervitaminosis D. 61
30651269 2019
15
Effect of molting on the concentration of plasma 25-hydroxyvitamin D in captive African penguins (Spheniscus demersus). 61
30308304 2019
16
Efficacy and Safety of 90,000 IU versus 300,000 IU Single Dose Oral Vitamin D in Nutritional Rickets: A Randomized Controlled Trial. 61
30766814 2018
17
Open-label study of treatment with alendronate sodium plus vitamin D in men and women with osteoporosis in Thailand. 61
30400864 2018
18
Increased rates of 25-hydroxy vitamin D testing: Dissecting a modern epidemic. 61
30026017 2018
19
Multiple renal calculi due to hypercalcaemia induced by over-the-counter vitamin D intoxication. 61
30131404 2018
20
Response to Long-term Vitamin D Therapy for Bone Disease in Children With Sickle Cell Disease. 61
29668535 2018
21
Risks of the 'Sunshine pill' - a case of hypervitaminosis D. 61
30072556 2018
22
Can adverse effects of excessive vitamin D supplementation occur without developing hypervitaminosis D? 61
28734988 2018
23
Soluble Klotho causes hypomineralization in Klotho-deficient mice. 61
29632215 2018
24
SUSPECTED HYPERVITAMINOSIS D IN RED-RUMPED AGOUTI ( DASYPROCTA LEPORINA) RECEIVING A COMMERCIAL RODENT DIET. 61
29517453 2018
25
Acute fish liver intoxication induced blisters formation and generalized skin peeling. 61
28841060 2018
26
Vitamin D Toxicity-A Clinical Perspective. 61
30294301 2018
27
Hypercalcemic pancreatitis a rare presentation of sarcoidosis: A case report. 61
29480854 2018
28
Vitamin D deficiency: Time for a reality check of the epidemiology. Re. "The increasing problem of subclinical and overt hypervitaminosis D in India: An institutional experience and review." 61
28652074 2018
29
How much is too much? Two contrasting cases of excessive vitamin D supplementation. 61
28801091 2017
30
Vitamin D in human reproduction: the more, the better? An evidence-based critical appraisal. 61
29028072 2017
31
Vitamin D toxicity of dietary origin in cats fed a natural complementary kitten food. 61
29270305 2017
32
Bi-allelic IARS mutations in a child with intra-uterine growth retardation, neonatal cholestasis, and mild developmental delay. 61
27891590 2017
33
The increasing problem of subclinical and overt hypervitaminosis D in India: An institutional experience and review. 61
28063517 2017
34
Hypervitaminosis D Associated With Tanning Bed Use: A Case Report. 61
28114469 2017
35
Prevalence of hypercalcemia related to hypervitaminosis D in clinical practice. 61
26995293 2016
36
Reduction of serum 25-hydroxyvitamin D concentrations with intravenous lipid emulsion in a dog. 61
27928177 2016
37
Influence hypervitaminosis D3 on hemodynamic presentation of experimental copper intoxication. 61
29244912 2016
38
Effect of intramuscular cholecalciferol megadose in children with nutritional rickets. 61
26913455 2016
39
Hypervitaminosis D with Dyslipidemia: An Unusual Scenario. 61
26897163 2016
40
Reversible vascular calcifications associated with hypervitaminosis D. 61
26318020 2016
41
[Hypervitaminosis D due to a dietary supplement]. 61
27071359 2016
42
A 23-year-old patient with secondary tumoral calcinosis: Regression after subtotal parathyroidectomy: A case report. 61
27088846 2016
43
Dystrophic mineralization of the arterial fibrovascular tissue associated with a vitamin D hypervitaminosis in an 8-year-old female Alpaca (Vicugna pacos). 61
28018578 2016
44
[Nephrocalcinosis in children]. 61
29710439 2015
45
Phenytoin Induced Osteopathy -Too Common to be Neglected. 61
26674262 2015
46
Unmasking of primary hyperparathyroidism by Vitamin D therapy. 61
26664216 2015
47
Acute Hypercalcaemia and Hypervitaminosis D in an Infant with Extra Pulmonary Tuberculosis. 61
26557587 2015
48
Rising trend in vitamin D status from 1993 to 2013: dual concerns for the future. 61
26034120 2015
49
Hypervitaminosis D and Metastatic Calcification in a Colony of Inbred Strain 13 Guinea Pigs, Cavia porcellus. 61
25281651 2015
50
Clinical investigation into feed-related hypervitaminosis D in a captive flock of budgerigars (Melopsittacus undulatus): morbidity, mortalities, and pathologic lesions. 61
25831571 2015
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Variations for Hypervitaminosis D

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Expression for Hypervitaminosis D

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Search GEO for disease gene expression data for Hypervitaminosis D.
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Pathways for Hypervitaminosis D

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Pathways related to Hypervitaminosis D according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Metabolism of fat-soluble vitamins 65
Show member pathways
 12 GC CYP27B1 CYP24A1
2
Signaling by FGFR2 65
Show member pathways
 11.94 KL GALNT3 FGF23
3
G alpha (s) signalling events 65
11.77 PTHLH PTH CALCA
4
Endocrine and other factor-regulated calcium reabsorption 36
11.28 VDR TRPV5 PTH KL
5
Parathyroid hormone synthesis, secretion and action 36
11.25 VDR TRPV5 PTHLH PTH KL FGF23
6
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.21 VDR PTH CYP27B1 CYP24A1 CALCA
7
Development_Hedgehog and PTH signaling pathways in bone and cartilage development 22
11.14 VDR PTHLH PTH
8
Nuclear Receptors in Lipid Metabolism and Toxicity 1
11.04 VDR CYP27B1 CYP24A1
9
TRP channels 65
10.85 TRPV6 TRPV5
10
Osteoblast Signaling 1
10.55 PTH FGF23
11
Vitamin D Metabolism 1
10.35 VDR PTH GC CYP27B1 CYP24A1
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GO Terms for Hypervitaminosis D

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Cellular components related to Hypervitaminosis D according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 PTHLH PTH KL GC FGF23 CALCA
2 cell GO:0005623 9.1 VDR TRPV6 TRPV5 PTH FGF23 CALCA

Biological processes related to Hypervitaminosis D according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.75 VDR PTHLH PTH
2 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.71 PTHLH PTH CALCA
3 fibroblast growth factor receptor signaling pathway GO:0008543 9.69 KL GALNT3 FGF23
4 calcium ion transport GO:0006816 9.67 VDR TRPV6 TRPV5 CYP27B1
5 positive regulation of bone mineralization GO:0030501 9.59 PTH KL
6 decidualization GO:0046697 9.58 VDR CYP27B1
7 regulation of bone mineralization GO:0030500 9.57 FGF23 CYP27B1
8 negative regulation of chondrocyte differentiation GO:0032331 9.56 PTHLH PTH
9 positive regulation of keratinocyte differentiation GO:0045618 9.55 VDR CYP27B1
10 calcium ion import across plasma membrane GO:0098703 9.52 TRPV6 TRPV5
11 response to vitamin D GO:0033280 9.5 PTH CYP27B1 CYP24A1
12 vitamin metabolic process GO:0006766 9.49 CYP27B1 CYP24A1
13 phosphate ion homeostasis GO:0055062 9.48 PTH FGF23
14 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 9.46 KL FGF23
15 vitamin D receptor signaling pathway GO:0070561 9.43 VDR CYP24A1
16 vitamin D catabolic process GO:0042369 9.43 FGF23 CYP27B1 CYP24A1
17 cAMP metabolic process GO:0046058 9.4 PTHLH PTH
18 calcium ion homeostasis GO:0055074 9.35 TRPV6 TRPV5 PTH KL CYP27B1
19 positive regulation of vitamin D 24-hydroxylase activity GO:0010980 9.33 VDR FGF23 CYP27B1
20 vitamin D metabolic process GO:0042359 9.02 VDR GC FGF23 CYP27B1 CYP24A1

Molecular functions related to Hypervitaminosis D according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibroblast growth factor receptor binding GO:0005104 9.26 KL FGF23
2 hormone activity GO:0005179 9.26 PTHLH PTH KL CALCA
3 peptide hormone receptor binding GO:0051428 9.16 PTHLH PTH
4 vitamin D binding GO:0005499 8.8 VDR KL GC
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Sources for Hypervitaminosis D

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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