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MCID: HYP057
MIFTS: 43

Hypervitaminosis D

Categories: Metabolic diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Hypervitaminosis D

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MalaCards integrated aliases for Hypervitaminosis D:

Name: Hypervitaminosis D 12 77 15 74

Classifications:

MalaCards categories:
Global: Metabolic diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:9971
ICD9CM 36 278.4
SNOMED-CT 69 27712000
ICD10 34 E67.3
UMLS 74 C1442839
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Summaries for Hypervitaminosis D

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Disease Ontology : 12 An overnutrition that is characterized by elevated vitamin D, which can subsequently cause high levels of calcium, has symptom myalgia, fatigue, irritability, nausea, dehydration, polyuria, and nephrocalcinosis, and possibly has material basis in excess intake of vitamin D.

MalaCards based summary : Hypervitaminosis D is related to calcinosis and bone resorption disease, and has symptoms including myalgia An important gene associated with Hypervitaminosis D is PTH (Parathyroid Hormone), and among its related pathways/superpathways are Parathyroid hormone synthesis, secretion and action and Endocrine and other factor-regulated calcium reabsorption. The drugs Ergocalciferol and Vitamin D have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and smooth muscle, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 77 Hypervitaminosis D is a state of vitamin D toxicity. The normal range for blood concentration is 30.0... more...

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Related Diseases for Hypervitaminosis D

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Diseases in the Hypervitaminosis a family:

Hypervitaminosis D

Diseases related to Hypervitaminosis D via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 calcinosis 30.2 FGF23 KL
2 bone resorption disease 29.9 PTH VDR
3 rickets 29.4 CYP27B1 FGF23 PTH VDR
4 hyperparathyroidism 29.2 CYP27B1 FGF23 PTH VDR
5 osteoporosis 28.7 CYP27B1 FGF23 KL PTH VDR
6 arterial calcification of infancy 11.3
7 oncogenic osteomalacia 10.1 FGF23 PTH
8 impaired renal function disease 10.1 FGF23 PTH
9 pulmonary alveolar microlithiasis 10.1 FGF23 PTH
10 metaphyseal chondrodysplasia, jansen type 10.1 FGF23 PTH
11 tracheal calcification 10.1 FGF23 KL
12 diabetes insipidus, nephrogenic, autosomal 10.1
13 arteriosclerosis 10.1
14 diabetes insipidus 10.1
15 hypophosphatemia 10.1 FGF23 PTH
16 familial tumoral calcinosis 10.1 FGF23 KL
17 idiopathic hypercalciuria 10.0 TRPV5 VDR
18 tumoral calcinosis, hyperphosphatemic, familial, 1 10.0 FGF23 KL
19 parathyroid adenoma 10.0 PTH VDR
20 vitamin d-dependent rickets, type 2a 10.0 CYP27B1 VDR
21 alagille syndrome 1 9.9
22 rheumatoid arthritis 9.9
23 cystic fibrosis 9.9
24 hypervitaminosis a 9.9
25 intracranial hypertension, idiopathic 9.9
26 aging 9.9
27 arthritis 9.9
28 mannosidosis 9.9
29 fanconi syndrome 9.9
30 pulmonary tuberculosis 9.9
31 pneumonia 9.9
32 hypoparathyroidism 9.9 FGF23 PTH
33 calciphylaxis 9.9 FGF23 PTH VDR
34 hypophosphatemic rickets, x-linked dominant 9.9 FGF23 KL PTH
35 hyperostosis 9.9 FGF23 KL
36 parathyroid gland disease 9.9 FGF23 PTH VDR
37 renal osteodystrophy 9.9 FGF23 PTH VDR
38 hypocalcemia, autosomal dominant 1 9.9 FGF23 PTH VDR
39 bone remodeling disease 9.9 FGF23 PTH VDR
40 urinary system disease 9.9 FGF23 KL PTH
41 primary hyperparathyroidism 9.9 FGF23 PTH VDR
42 spondylosis 9.8 KL PTH VDR
43 bone disease 9.8 FGF23 PTH VDR
44 uremia 9.8 PTH VDR
45 kidney disease 9.7 FGF23 PTH VDR
46 hypercalcemia, infantile, 1 9.7 CYP24A1 PTH VDR
47 hyperphosphatemia 9.6 FGF23 KL PTH VDR
48 secondary hyperparathyroidism of renal origin 9.5 CYP27B1 FGF23 PTH VDR
49 hypophosphatemic rickets with hypercalciuria, hereditary 9.5 CYP27B1 FGF23 KL PTH
50 chronic kidney failure 9.5 CYP27B1 FGF23 PTH VDR

Graphical network of the top 20 diseases related to Hypervitaminosis D:



Diseases related to Hypervitaminosis D
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Symptoms & Phenotypes for Hypervitaminosis D

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Symptoms:

12
  • • myalgia

MGI Mouse Phenotypes related to Hypervitaminosis D:

47 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.98 CYP24A1 CYP27B1 FGF23 KL PTH TRPV5
2 homeostasis/metabolism MP:0005376 9.91 CYP24A1 CYP27B1 FGF23 KL PTH TRPV5
3 hematopoietic system MP:0005397 9.88 CYP27B1 FGF23 KL PTH TRPV5 VDR
4 endocrine/exocrine gland MP:0005379 9.85 CYP27B1 FGF23 KL PTH VDR
5 cardiovascular system MP:0005385 9.81 FGF23 KL PTH VDR
6 craniofacial MP:0005382 9.8 CYP27B1 KL PTH VDR
7 immune system MP:0005387 9.8 CYP27B1 FGF23 KL PTH TRPV5 VDR
8 digestive/alimentary MP:0005381 9.78 FGF23 KL TRPV5 VDR
9 limbs/digits/tail MP:0005371 9.65 CYP27B1 FGF23 KL PTH VDR
10 renal/urinary system MP:0005367 9.63 CYP24A1 CYP27B1 FGF23 KL TRPV5 VDR
11 reproductive system MP:0005389 9.35 CYP24A1 CYP27B1 FGF23 KL VDR
12 skeleton MP:0005390 9.17 CYP24A1 CYP27B1 FGF23 KL PTH TRPV5
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Drugs & Therapeutics for Hypervitaminosis D

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Drugs for Hypervitaminosis D (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-14-6 5280793
2
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1406-16-2
3
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 67-97-0 5280795 6221
4
Calcifediol Approved, Nutraceutical Phase 4 19356-17-3 5283731 6433735
5
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7440-70-2 271
6 Calciferol Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
7 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
8 Ergocalciferols Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
9 Vitamin D2 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
10 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11 Nutrients Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
13 Vitamins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
14 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
15 Hydroxycholecalciferols Phase 4
16 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
17 Pharmaceutical Solutions Phase 2,Not Applicable
18 Anti-Infective Agents Phase 2
19 Hepcidins Phase 2
20 Olive Not Applicable

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 The Effect of Supplementation With Two Different Doses of Vitamin D on Bone Mineral Density, Vitamin D Levels and Hand Grip Strength in Children With Diabetes Mellitus Type 1 Completed NCT01277913 Phase 4 Vitamin D3;Vitamin D3
2 A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT Enrolling by invitation NCT03176849 Phase 4
3 Rapid Normalization of Vitamin D Deficiency in PICU Not yet recruiting NCT03742505 Phase 3 Cholecalciferol
4 Prevention of Vitamin D Deficiency Following Pediatric CHD Surgery: a Phase II Dose Evaluation Randomized Controlled Trial Comparing Usual Care With a High Dose Pre-operative Supplementation Regimen Based on the Institute of Medicine Daily Upper Tolerable Intake Level Completed NCT01838447 Phase 2
5 Vitamin D as a Modifier of Serum Hepcidin in Children With Chronic Kidney Disease Completed NCT01532349 Phase 2 Cholecalciferol
6 Vitamin D and Severe Asthma Exacerbations Completed NCT01921894 Phase 1
7 Pilot Trial to Evaluate the Effect of Vitamin D on Melanocyte Biomarkers Completed NCT01477463 Not Applicable Vitamin D3;placebo and vitamin D
8 Change in Free 25(OH)D After High Dose in Vitamin D Deficient Postmenopausal Women Completed NCT02553044 Not Applicable
9 Efficacy of Vitamin D Therapy on Glucose Homeostasis in Obese Adolescents Completed NCT02414529 Not Applicable Vitamin D2;Placebo
10 Randomized Study of Two Vitamin D Dosing Strategies in Children With Chronic Kidney Disease Active, not recruiting NCT01909115 Not Applicable
11 Dose-dependent Effects of Vitamin D on Bone Health Active, not recruiting NCT01900860 Not Applicable

Search NIH Clinical Center for Hypervitaminosis D

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Genetic Tests for Hypervitaminosis D

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Anatomical Context for Hypervitaminosis D

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MalaCards organs/tissues related to Hypervitaminosis D:

42
Bone, Kidney, Smooth Muscle, Placenta
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Publications for Hypervitaminosis D

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Articles related to Hypervitaminosis D:

(show top 50) (show all 123)
# Title Authors Year
1
CYP24A1 mutations and hypervitaminosis D. ( 30651269 )
2019
2
Redundancy Is of No Good; Iatrogenic Hypervitaminosis D: A Rare Case of Persistent Vomiting Due to Hypercalcemia. ( 30792578 )
2019
3
SUSPECTED HYPERVITAMINOSIS D IN RED-RUMPED AGOUTI ( DASYPROCTA LEPORINA) RECEIVING A COMMERCIAL RODENT DIET. ( 29517453 )
2018
4
Risks of the 'Sunshine pill' - a case of hypervitaminosis D. ( 30072556 )
2018
5
Hypervitaminosis D Associated With Tanning Bed Use: A Case Report. ( 28114469 )
2017
6
Can adverse effects of excessive vitamin D supplementation occur without developing hypervitaminosis D? ( 28734988 )
2017
7
Vitamin D deficiency: It is time for reality check of the epidemiology. Re. "The increasing problem of subclinical and overt hypervitaminosis D in India: An institutional experience and review." ( 28652074 )
2017
8
The increasing problem of subclinical and overt hypervitaminosis D in India: An institutional experience and review. ( 28063517 )
2017
9
Prevalence of hypercalcemia related to hypervitaminosis D in clinical practice. ( 26995293 )
2016
10
Hypervitaminosis D with Dyslipidemia: An Unusual Scenario. ( 26897163 )
2016
11
Clinical investigation into feed-related hypervitaminosis D in a captive flock of budgerigars (Melopsittacus undulatus): morbidity, mortalities, and pathologic lesions. ( 25831571 )
2015
12
Reversible vascular calcifications associated with hypervitaminosis D. ( 26318020 )
2015
13
Acute Hypercalcaemia and Hypervitaminosis D in an Infant with Extra Pulmonary Tuberculosis. ( 26557587 )
2015
14
Hypervitaminosis-D, an uncommon reality! ( 25906526 )
2014
15
Hypervitaminosis D and Metastatic Calcification in a Colony of Inbred Strain 13 Guinea Pigs, Cavia porcellus. ( 25281651 )
2014
16
Tanning beds and hypervitaminosis D: a case report. ( 24887628 )
2014
17
Iatrogenic hypervitaminosis D as an unusual cause of persistent vomiting: a case report. ( 24571630 )
2014
18
Maternal hypervitaminosis D reduces fetal bone mass and mineral acquisition and leads to neonatal lethality. ( 23895994 )
2013
19
Early life permethrin exposure leads to hypervitaminosis D, nitric oxide and catecholamines impairment. ( 25149241 )
2013
20
Hypervitaminosis D in guinea pigs with I+-mannosidosis. ( 23582422 )
2013
21
Treatment of nephrogenic diabetes insipidus due to hypervitaminosis D. ( 23756934 )
2013
22
Hypervitaminosis D causing nephrogenic diabetes insipidus in a 5-month-old infant. ( 23396467 )
2013
23
"Excess gooD can be Dangerous". A case series of iatrogenic symptomatic hypercalcemia due to hypervitaminosis D. ( 23087723 )
2012
24
Serum levels of 3-epi-25-OH-D3 during hypervitaminosis D in clinical practice. ( 23038681 )
2012
25
Hypervitaminosis D: case report of pediatric osteoporosis secondary to cystic fibrosis. ( 22461833 )
2011
26
Hypervitaminosis D associated with a vitamin D dispensing error. ( 21917555 )
2011
27
Neurofibromatosis, pathological fracture and hypervitaminosis-D. ( 21048240 )
2010
28
Pseudotumor cerebri due to hypervitaminosis A or hypervitaminosis D or both in Alagille syndrome. ( 19619235 )
2010
29
Hypercalcemia due to hypervitaminosis D: report of seven patients. ( 19339514 )
2009
30
Ventricular-arterial coupling in a rat model of reduced arterial compliance provoked by hypervitaminosis D and nicotine. ( 16699077 )
2006
31
Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice. ( 16731043 )
2006
32
Hypervitaminosis D mediates compensatory Ca2+ hyperabsorption in TRPV5 knockout mice. ( 16148038 )
2005
33
Risk of hypervitaminosis D from prolonged feeding of high vitamin D premature infant formula. ( 15310310 )
2004
34
1,25-dihydroxyvitamin D3 receptor is upregulated in aortic smooth muscle cells during hypervitaminosis D. ( 12002522 )
2002
35
Hypercalcemia and hypervitaminosis D in two lambs. ( 10754674 )
2000
36
Effects of plant-induced hypervitaminosis D on cutaneous structure, cell differentiation and cell proliferation in cattle. ( 10887751 )
2000
37
Hypervitaminosis D: Report on three patients. ( 17341976 )
1998
38
Dental changes in hypervitaminosis D. ( 9574950 )
1998
39
[Hypervitaminosis D in institutionalized elderly in Buenos Aires]. ( 9435366 )
1997
40
An outbreak of hypervitaminosis D associated with the overfortification of milk from a home-delivery dairy. ( 7733425 )
1995
41
Hypervitaminosis D after prolonged feeding with a premature formula. ( 8233752 )
1993
42
Hypervitaminosis D associated with drinking milk. ( 1313547 )
1992
43
Up-regulation of the intestinal 1,25-dihydroxyvitamin D receptor during hypervitaminosis D: a comparison between vitamin D2 and vitamin D3. ( 2163637 )
1990
44
Effect of ethane-I-hydroxy-I, I-diphosphonate on arterial calcinosis induced by hypervitaminosis D: a morphologic investigation. ( 2109995 )
1990
45
Ultrastructural study of hypervitaminosis D induced arterial calcification in Wistar rats. ( 3207390 )
1988
46
Dietary magnesium effect on swine coronary atherosclerosis induced by hypervitaminosis D. ( 2820185 )
1987
47
Severe depressive illness in the context of hypervitaminosis D. ( 3664111 )
1987
48
The osteodystrophy of hypervitaminosis D: a metabolic study. ( 3498181 )
1986
49
Hypervitaminosis D in the chick embryo: comparative study on the activity of various vitamin D3 metabolites. ( 6091851 )
1984
50
Effect of alkali on metastatic calcification produced by hypervitaminosis D. ( 6098694 )
1984
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Variations for Hypervitaminosis D

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Expression for Hypervitaminosis D

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Search GEO for disease gene expression data for Hypervitaminosis D.
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Pathways for Hypervitaminosis D

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Pathways related to Hypervitaminosis D according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Parathyroid hormone synthesis, secretion and action 38
11.19 CYP24A1 CYP27B1 FGF23 KL PTH TRPV5
2
Endocrine and other factor-regulated calcium reabsorption 38
11.18 KL TRPV5 VDR
3
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.11 CYP24A1 CYP27B1 PTH VDR
4
Development_Hedgehog and PTH signaling pathways in bone and cartilage development 23
11 PTH VDR
5
Nuclear Receptors in Lipid Metabolism and Toxicity 1
10.98 CYP24A1 CYP27B1 VDR
6
Osteoblast Signaling 1
10.51 FGF23 PTH
7
Vitamin D Metabolism 1
10.26 CYP24A1 CYP27B1 PTH VDR
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GO Terms for Hypervitaminosis D

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Biological processes related to Hypervitaminosis D according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.74 FGF23 KL PTH
2 calcium ion transport GO:0006816 9.62 CYP27B1 PTH TRPV5 VDR
3 cellular calcium ion homeostasis GO:0006874 9.58 PTH VDR
4 fibroblast growth factor receptor signaling pathway GO:0008543 9.58 FGF23 KL
5 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.56 FGF23 KL
6 bone mineralization GO:0030282 9.55 CYP27B1 PTH
7 positive regulation of bone mineralization GO:0030501 9.54 KL PTH
8 calcium ion homeostasis GO:0055074 9.54 CYP27B1 KL TRPV5
9 decidualization GO:0046697 9.52 CYP27B1 VDR
10 regulation of bone mineralization GO:0030500 9.51 CYP27B1 FGF23
11 positive regulation of keratinocyte differentiation GO:0045618 9.49 CYP27B1 VDR
12 vitamin metabolic process GO:0006766 9.48 CYP24A1 CYP27B1
13 phosphate ion homeostasis GO:0055062 9.46 FGF23 PTH
14 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 9.43 FGF23 KL
15 response to vitamin D GO:0033280 9.43 CYP24A1 CYP27B1 PTH
16 vitamin D receptor signaling pathway GO:0070561 9.4 CYP24A1 VDR
17 positive regulation of vitamin D 24-hydroxylase activity GO:0010980 9.33 CYP27B1 FGF23 VDR
18 vitamin D catabolic process GO:0042369 9.13 CYP24A1 CYP27B1 FGF23
19 vitamin D metabolic process GO:0042359 8.92 CYP24A1 CYP27B1 FGF23 VDR

Molecular functions related to Hypervitaminosis D according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.32 CYP24A1 CYP27B1
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.26 FGF23 KL
3 1-phosphatidylinositol-3-kinase activity GO:0016303 9.16 FGF23 KL
4 fibroblast growth factor receptor binding GO:0005104 8.96 FGF23 KL
5 vitamin D binding GO:0005499 8.62 KL VDR
Sources

Sources for Hypervitaminosis D

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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