Aliases & Classifications for Hypervitaminosis D

MalaCards integrated aliases for Hypervitaminosis D:

Name: Hypervitaminosis D 12 73 15 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:9971
ICD9CM 34 278.4
SNOMED-CT 67 190969000
ICD10 32 E67.3
UMLS 70 C1442839

Summaries for Hypervitaminosis D

Disease Ontology : 12 An overnutrition that is characterized by elevated vitamin D, which can subsequently cause high levels of calcium, has symptom myalgia, fatigue, irritability, nausea, dehydration, polyuria, and nephrocalcinosis, and possibly has material basis in excess intake of vitamin D.

MalaCards based summary : Hypervitaminosis D is related to arterial calcification of infancy and calcinosis, and has symptoms including myalgia An important gene associated with Hypervitaminosis D is PTH (Parathyroid Hormone), and among its related pathways/superpathways are Metabolism of fat-soluble vitamins and Signaling by FGFR2. Affiliated tissues include bone, smooth muscle and skeletal muscle, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 73 Vitamin D toxicity, or hypervitaminosis D is the toxic state of an excess of vitamin D. The normal range... more...

Related Diseases for Hypervitaminosis D

Diseases in the Hypervitaminosis a family:

Hypervitaminosis D

Diseases related to Hypervitaminosis D via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)
# Related Disease Score Top Affiliating Genes
1 arterial calcification of infancy 31.8 KL GALNT3 FGF23
2 calcinosis 30.1 KL GALNT3 FGF23 CALCA
3 rickets 29.9 VDR PTH KL GC FGF23 CYP27B1
4 renal osteodystrophy 29.5 VDR PTH FGF23 CALCA
5 nephrolithiasis 29.5 VDR TRPV5 PTH FGF23 CYP24A1
6 hyperphosphatemia 29.5 VDR PTH KL GALNT3 FGF23
7 bone resorption disease 29.3 VDR PTHLH PTH FGF23 CALCA
8 hypoparathyroidism 29.3 VDR PTHLH PTH FGF23 CALCA
9 hypophosphatemia 29.2 VDR PTHLH PTH KL FGF23 CYP27B1
10 hypocalcemia, autosomal dominant 1 28.9 VDR PTHLH PTH FGF23 CYP27B1 CALCA
11 hyperparathyroidism 28.5 VDR TRPV6 PTHLH PTH KL GC
12 secondary hyperparathyroidism 28.4 VDR PTH KL GC FGF23 CYP27B1
13 primary hyperparathyroidism 28.3 VDR PTHLH PTH KL GC FGF23
14 osteoporosis 28.0 VDR PTHLH PTH KL GC FGF23
15 nephrocalcinosis 10.3
16 hyperlipoproteinemia, type v 10.2 KL FGF23
17 malignant choroid melanoma 10.2 CYP27B1 CYP24A1
18 vitamin d-dependent rickets, type 2a 10.2 VDR CYP27B1
19 idiopathic hypercalciuria 10.2 VDR TRPV5
20 tracheal calcification 10.2 PTH KL FGF23
21 nephrolithiasis/osteoporosis, hypophosphatemic, 1 10.2 PTH KL FGF23
22 pediatric ovarian germ cell tumor 10.2 PTHLH PTH
23 pediatric ovarian dysgerminoma 10.2 PTHLH PTH
24 sclerosing hepatic carcinoma 10.2 PTHLH PTH
25 pulmonary alveolar microlithiasis 10.2 GALNT3 FGF23
26 invasive malignant thymoma 10.1 PTHLH PTH
27 eiken syndrome 10.1 PTHLH PTH
28 paraneoplastic syndromes 10.1 PTHLH FGF23
29 mycobacterium tuberculosis 1 10.1
30 arteriosclerosis 10.1
31 spondylosis 10.1 VDR PTH KL
32 calciphylaxis 10.1 VDR PTH FGF23
33 pseudopseudohypoparathyroidism 10.1 PTHLH PTH
34 substernal goiter 10.1 PTH CALCA
35 hepatocellular clear cell carcinoma 10.1 VDR KL FGF23
36 hypophosphatasia 10.1 PTH FGF23
37 metatropic dysplasia 10.1 TRPV6 TRPV5
38 conjunctival deposit 10.1 KL GALNT3 FGF23
39 vitamin d-dependent rickets 10.1 VDR PTH CYP27B1
40 endemic goiter 10.1 PTH CALCA
41 suppurative thyroiditis 10.1 PTH CALCA
42 familial tumoral calcinosis 10.1 KL GALNT3 FGF23
43 osteoglophonic dysplasia 10.1 KL GALNT3 FGF23
44 giant cell reparative granuloma 10.1 PTH CALCA
45 nontoxic goiter 10.1 PTH CALCA
46 chondrodysplasia, blomstrand type 10.1 PTHLH PTH
47 tooth resorption 10.1 PTH CALCA
48 scapuloperoneal spinal muscular atrophy 10.1 TRPV6 TRPV5
49 graves disease 1 10.1 PTH CALCA
50 hyperostosis 10.1 KL GALNT3 FGF23

Graphical network of the top 20 diseases related to Hypervitaminosis D:



Diseases related to Hypervitaminosis D

Symptoms & Phenotypes for Hypervitaminosis D

Symptoms:

12
  • myalgia

MGI Mouse Phenotypes related to Hypervitaminosis D:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.07 CYP24A1 CYP27B1 FGF23 GALNT3 KL PTH
2 homeostasis/metabolism MP:0005376 10.02 CYP24A1 CYP27B1 FGF23 GALNT3 GC KL
3 endocrine/exocrine gland MP:0005379 10.01 CYP27B1 FGF23 GALNT3 GC KL PTH
4 craniofacial MP:0005382 9.93 CYP27B1 GALNT3 KL PTH PTHLH VDR
5 digestive/alimentary MP:0005381 9.91 FGF23 GALNT3 KL PTHLH TRPV5 VDR
6 limbs/digits/tail MP:0005371 9.8 CYP27B1 FGF23 GALNT3 KL PTH PTHLH
7 renal/urinary system MP:0005367 9.76 CYP24A1 CYP27B1 FGF23 GALNT3 KL PTHLH
8 reproductive system MP:0005389 9.56 CYP24A1 CYP27B1 FGF23 GALNT3 KL PTHLH
9 skeleton MP:0005390 9.32 CYP24A1 CYP27B1 FGF23 GALNT3 GC KL

Drugs & Therapeutics for Hypervitaminosis D

Search Clinical Trials , NIH Clinical Center for Hypervitaminosis D

Genetic Tests for Hypervitaminosis D

Anatomical Context for Hypervitaminosis D

MalaCards organs/tissues related to Hypervitaminosis D:

40
Bone, Smooth Muscle, Skeletal Muscle, Placenta, Prostate, Cervix

Publications for Hypervitaminosis D

Articles related to Hypervitaminosis D:

(show top 50) (show all 362)
# Title Authors PMID Year
1
Management of hypercalcaemia due to hypervitaminosis D. 61
33738940 2021
2
Pre-analytical mysteries: A case of severe hypervitaminosis D and mild hypercalcaemia. 61
33380896 2021
3
Forget the phosphorus: A case of hypervitaminosis D-induced symptomatic hypercalcemia. 61
33614397 2021
4
Abnormal FDG Uptake on PET/CT Due to Periosteal Reaction Caused by Hypervitaminosis D in a Pediatric Patient. 61
32796238 2020
5
Hypercalcemia Without Hypervitaminosis D During Cholecalciferol Supplementation in Critically Ill Patients. 61
31605425 2020
6
Hypervitaminosis D and Cortical Venous Thrombosis; An Unusual Presentation. 61
32798350 2020
7
Protocol of the VICTORIA study: personalized vitamin D supplementation for reducing or preventing fatigue and enhancing quality of life of patients with colorectal tumor - randomized intervention trial. 61
32770972 2020
8
A Curious Case of Hypervitaminosis D. 61
32656031 2020
9
Biallelic CYP24A1 variants presenting during pregnancy: clinical and biochemical phenotypes. 61
32375123 2020
10
Exogenous intoxication by non-prescribed use of vitamin D, a case report. 61
32580697 2020
11
Hypercalcemia, nephrolithiasis, and hypervitaminosis D precipitated by supplementation in a susceptible individual. 61
32222584 2020
12
Development and application of a LC-MS/MS assay for simultaneous analysis of 25-hydroxyvitamin-D and 3-epi-25-hydroxyvitamin-D metabolites in canine serum. 61
31958632 2020
13
Long-term hypervitaminosis D-induced hypercalcaemia treated with glucocorticoids and bisphosphonates. 61
32354763 2020
14
Changing Trend in Vitamin D Status from 2008 to 2016: An Experience from a Tertiary Care Institute in North India. 61
32699781 2020
15
HYPERVITAMINOSIS D IN A GIANT ANTEATER (MYRMECOPHAGA TRIDACTYLA) AND A LARGE HAIRY ARMADILLO (CHAETOPHRACTUS VILLOSUS) RECEIVING A COMMERCIAL INSECTIVORE DIET. 61
32212572 2020
16
Toxicity of Herbs, Vitamins, and Supplements. 61
32147004 2020
17
Unique case of profound iatrogenic hypercalcemia in a patient with recent orthopedic prosthetic infection. 61
33240748 2020
18
Hypervitaminosis D without toxicity. 61
32063764 2020
19
S179D Prolactin Sensitizes Human PC3 Prostate Cancer Xenografts to Anti-tumor Effects of Well-Tolerated Doses of Calcitriol. 61
33179012 2020
20
Hypervitaminosis D has no positive effects on goat tuberculosis and may cause chronic renal lesions. 61
31690642 2019
21
Intractable hypercalcaemia during pregnancy and the postpartum secondary to pathogenic variants in CYP24A1. 61
31751313 2019
22
Normocalcemia in the Face of Marked Hypervitaminosis D: The Utility of Vitamin D Metabolite Profiling. 61
31639673 2019
23
Hypercalcaemia due to Hypervitaminosis D in a Self-Supplementing Multiple Sclerosis Patient: A Case Report 61
31538442 2019
24
A randomised trial of vitamin D in acute-stage allergic bronchopulmonary aspergillosis complicating asthma. 61
30561849 2019
25
Appearances of soft tissue calcification on Tc99m MDP bone scan. 61
31000873 2019
26
Calcioic acid: In vivo detection and quantification of the terminal C24-oxidation product of 25-hydroxyvitamin D3 and related intermediates in serum of mice treated with 24,25-dihydroxyvitamin D3. 61
30553931 2019
27
Laboratory trend in vitamin D status in Ireland: Dual concerns about low and high 25OHD. 61
30296586 2019
28
Expansive Vascular Remodeling and Increased Vascular Calcification Response to Cholecalciferol in a Murine Model of Obesity and Insulin Resistance. 61
30580565 2019
29
Acute hypercalcemia and hypervitaminosis D associated with pulmonary tuberculosis in an elderly patient : A case report and review of the literature. 61
31656304 2019
30
Severity of Ionized Hypercalcemia and Hypocalcemia Is Associated With Etiology in Dogs and Cats. 61
31508432 2019
31
Effect of molting on the concentration of plasma 25-hydroxyvitamin D in captive African penguins (Spheniscus demersus). 61
30308304 2019
32
CYP24A1 mutations and hypervitaminosis D. 61
30651269 2019
33
Redundancy Is of No Good; Iatrogenic Hypervitaminosis D: A Rare Case of Persistent Vomiting Due to Hypercalcemia. 61
30792578 2019
34
Efficacy and Safety of 90,000 IU versus 300,000 IU Single Dose Oral Vitamin D in Nutritional Rickets: A Randomized Controlled Trial. 61
30766814 2018
35
Open-label study of treatment with alendronate sodium plus vitamin D in men and women with osteoporosis in Thailand. 61
30400864 2018
36
Increased rates of 25-hydroxy vitamin D testing: Dissecting a modern epidemic. 61
30026017 2018
37
Multiple renal calculi due to hypercalcaemia induced by over-the-counter vitamin D intoxication. 61
30131404 2018
38
Risks of the 'Sunshine pill' - a case of hypervitaminosis D. 61
30072556 2018
39
Response to Long-term Vitamin D Therapy for Bone Disease in Children With Sickle Cell Disease. 61
29668535 2018
40
Can adverse effects of excessive vitamin D supplementation occur without developing hypervitaminosis D? 61
28734988 2018
41
Soluble Klotho causes hypomineralization in Klotho-deficient mice. 61
29632215 2018
42
SUSPECTED HYPERVITAMINOSIS D IN RED-RUMPED AGOUTI ( DASYPROCTA LEPORINA) RECEIVING A COMMERCIAL RODENT DIET. 61
29517453 2018
43
Acute fish liver intoxication induced blisters formation and generalized skin peeling. 61
28841060 2018
44
Vitamin D Toxicity-A Clinical Perspective. 61
30294301 2018
45
Hypercalcemic pancreatitis a rare presentation of sarcoidosis: A case report. 61
29480854 2018
46
Vitamin D deficiency: Time for a reality check of the epidemiology. Re. "The increasing problem of subclinical and overt hypervitaminosis D in India: An institutional experience and review." 61
28652074 2018
47
How much is too much? Two contrasting cases of excessive vitamin D supplementation. 61
28801091 2017
48
Vitamin D in human reproduction: the more, the better? An evidence-based critical appraisal. 61
29028072 2017
49
Vitamin D toxicity of dietary origin in cats fed a natural complementary kitten food. 61
29270305 2017
50
Bi-allelic IARS mutations in a child with intra-uterine growth retardation, neonatal cholestasis, and mild developmental delay. 61
27891590 2017

Variations for Hypervitaminosis D

Expression for Hypervitaminosis D

Search GEO for disease gene expression data for Hypervitaminosis D.

Pathways for Hypervitaminosis D

GO Terms for Hypervitaminosis D

Cellular components related to Hypervitaminosis D according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 PTHLH PTH KL GC FGF23 CALCA
2 calcium channel complex GO:0034704 8.62 TRPV6 TRPV5

Biological processes related to Hypervitaminosis D according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.74 VDR PTHLH PTH
2 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.71 PTHLH PTH CALCA
3 cellular calcium ion homeostasis GO:0006874 9.7 VDR PTH CALCA
4 fibroblast growth factor receptor signaling pathway GO:0008543 9.69 KL GALNT3 FGF23
5 calcium ion transport GO:0006816 9.67 VDR TRPV6 TRPV5 CYP27B1
6 positive regulation of bone mineralization GO:0030501 9.6 PTH KL
7 decidualization GO:0046697 9.59 VDR CYP27B1
8 regulation of bone mineralization GO:0030500 9.58 FGF23 CYP27B1
9 negative regulation of chondrocyte differentiation GO:0032331 9.58 PTHLH PTH
10 positive regulation of keratinocyte differentiation GO:0045618 9.56 VDR CYP27B1
11 calcium ion import across plasma membrane GO:0098703 9.55 TRPV6 TRPV5
12 response to vitamin D GO:0033280 9.5 PTH CYP27B1 CYP24A1
13 phosphate ion homeostasis GO:0055062 9.49 PTH FGF23
14 vitamin metabolic process GO:0006766 9.48 CYP27B1 CYP24A1
15 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 9.46 KL FGF23
16 vitamin D receptor signaling pathway GO:0070561 9.43 VDR CYP24A1
17 vitamin D catabolic process GO:0042369 9.43 FGF23 CYP27B1 CYP24A1
18 cAMP metabolic process GO:0046058 9.4 PTHLH PTH
19 calcium ion homeostasis GO:0055074 9.35 TRPV6 TRPV5 PTH KL CYP27B1
20 positive regulation of vitamin D 24-hydroxylase activity GO:0010980 9.33 VDR FGF23 CYP27B1
21 vitamin D metabolic process GO:0042359 9.02 VDR GC FGF23 CYP27B1 CYP24A1

Molecular functions related to Hypervitaminosis D according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibroblast growth factor receptor binding GO:0005104 9.26 KL FGF23
2 peptide hormone receptor binding GO:0051428 9.16 PTHLH PTH
3 vitamin D binding GO:0005499 8.96 KL GC
4 hormone activity GO:0005179 8.92 PTHLH PTH KL CALCA

Sources for Hypervitaminosis D

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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