MCID: HYP189
MIFTS: 41

Hypoadrenalism

Categories: Endocrine diseases, Rare diseases

Aliases & Classifications for Hypoadrenalism

MalaCards integrated aliases for Hypoadrenalism:

Name: Hypoadrenalism 53 55
Adrenal Gland Hypofunction 73
Hypoaldosteronism 73

Classifications:



External Ids:

Summaries for Hypoadrenalism

MalaCards based summary : Hypoadrenalism, also known as adrenal gland hypofunction, is related to hypoadrenocorticism, familial and hypopituitarism. An important gene associated with Hypoadrenalism is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Neuroscience. The drugs Hydrocortisone acetate and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and pituitary, and related phenotypes are adipose tissue and endocrine/exocrine gland

Wikipedia : 76 Adrenal insufficiency is a condition in which the adrenal glands do not produce adequate amounts of... more...

Related Diseases for Hypoadrenalism

Diseases related to Hypoadrenalism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Related Disease Score Top Affiliating Genes
1 hypoadrenocorticism, familial 31.8 CRH POMC
2 hypopituitarism 30.2 CRH GH1 POMC
3 diabetes insipidus 30.2 CRH POMC
4 conn's syndrome 30.1 CRH GH1 POMC
5 amenorrhea 29.9 CRH POMC SHBG
6 hypothyroidism 29.7 CALCA GH1 POMC SHBG TG
7 hyperthyroidism 29.5 GH1 SHBG TG
8 achalasia-addisonianism-alacrima syndrome 11.2
9 proprotein convertase 1/3 deficiency 11.1
10 gangliocytoma 10.2 CRH POMC
11 pituitary carcinoma 10.2 CRH POMC
12 acth deficiency, isolated 10.2 CRH POMC
13 nelson syndrome 10.2 CRH POMC
14 sheehan syndrome 10.2 CRH POMC
15 lung oat cell carcinoma 10.2 CALCA POMC
16 acth-secreting pituitary adenoma 10.2 CRH POMC
17 fasting hypoglycemia 10.2 CRH POMC
18 adrenal cortical hypofunction 10.2 CRH POMC
19 secondary hypertrophic osteoarthropathy 10.2 CALCA POMC
20 cytochrome p450 oxidoreductase deficiency 10.2 CYP1A2 POMC
21 withdrawal disorder 10.2 CRH POMC
22 ectopic cushing syndrome 10.2 CRH POMC
23 persistent fetal circulation syndrome 10.2 CRH POMC
24 adrenal cortex disease 10.2 CRH POMC
25 pituitary-dependent cushing's disease 10.2 CRH POMC
26 adrenal gland disease 10.1 CRH POMC
27 lymphocytic hypophysitis 10.1 GH1 POMC
28 adenohypophysitis 10.1 GH1 POMC
29 postmenopausal atrophic vaginitis 10.1 POMC SHBG
30 hyperproinsulinemia 10.1 PCSK1 SHBG
31 empty sella syndrome 10.1 GH1 POMC
32 hyperpituitarism 10.1 GH1 POMC
33 tsh producing pituitary tumor 10.1 GH1 POMC
34 endocrine organ benign neoplasm 10.1 CALCA POMC
35 functioning pituitary adenoma 10.1 GH1 POMC
36 fetal erythroblastosis 10.1 POMC SHBG
37 mental depression 10.1 CRH POMC
38 sex differentiation disease 10.1 POMC SHBG
39 adrenal adenoma 10.1 CRH POMC
40 chromophobe adenoma 10.1 GH1 POMC
41 pituitary tumors 10.1 GH1 POMC
42 pituitary hormone deficiency, combined, 2 10.1 GH1 POMC
43 hypercalcemia, infantile, 1 10.1 CALCA PTHLH
44 marasmus 10.1 GH1 SHBG
45 gynecomastia 10.1 POMC SHBG
46 adrenal carcinoma 10.1 CRH POMC
47 fibrous dysplasia 10.0 CALCA GH1
48 endocrine exophthalmos 10.0 POMC TG
49 islet cell tumor 10.0 CALCA PTHLH
50 hypogonadism 10.0

Graphical network of the top 20 diseases related to Hypoadrenalism:



Diseases related to Hypoadrenalism

Symptoms & Phenotypes for Hypoadrenalism

MGI Mouse Phenotypes related to Hypoadrenalism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.35 CRH PCSK1 POMC PTHLH TG
2 endocrine/exocrine gland MP:0005379 9.1 CRH CYP1A2 PCSK1 POMC PTHLH TG

Drugs & Therapeutics for Hypoadrenalism

Drugs for Hypoadrenalism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 258)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-03-3
2
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 51-43-4 5816
3
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-23-7 5754
4
Racepinephrine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 329-65-7 838
5
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 1,Not Applicable 1177-87-3
6
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 1,Not Applicable 50-02-2 5743
7
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
8
Cosyntropin Approved Phase 4,Phase 3,Not Applicable,Early Phase 1 16960-16-0 16129617
9
Cortisone acetate Approved, Investigational Phase 4,Not Applicable 1950-04-4, 50-04-4 5745
10
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2 2921-57-5
11
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
12
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2 302-25-0
13
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
14
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
15
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 2078-54-8 4943
16
Etomidate Approved Phase 4,Phase 2,Phase 3,Not Applicable 33125-97-2 667484 36339
17
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
18
Celecoxib Approved, Investigational Phase 4,Phase 2 169590-42-5 2662
19
Citalopram Approved Phase 4 59729-33-8 2771
20 tannic acid Approved Phase 4,Phase 3,Phase 2
21
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2 94-09-7, 1994-09-7 2337
22
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 6740-88-1 3821
23
Fludrocortisone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 127-31-1 31378
24
Sulfamethazine Approved, Investigational, Vet_approved Phase 4 57-68-1 5327
25
Cortisone Experimental Phase 4,Not Applicable 53-06-5 222786
26
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2 2920-86-7
27 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Hydrocortisone-17-butyrate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
29 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
30 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
31 Epinephryl borate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
32 Hydrocortisone 17-butyrate 21-propionate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
33 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
35 Cortisol succinate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
36 Sympathomimetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
37 Vasoconstrictor Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
38 Adrenergic alpha-Agonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
39 Adrenergic beta-Agonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
40 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
41 Mydriatics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
42 Adrenergic Agonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 Adrenergic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
44 Anti-Asthmatic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
45 Respiratory System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
46 BB 1101 Phase 4,Phase 1,Not Applicable
47 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
48 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
49 Bronchodilator Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
50 Protective Agents Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 202)
# Name Status NCT ID Phase Drugs
1 Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT00773058 Phase 4 hydrocortisone;placebo
2 The Effect of Branched-chain Amino Acid on the Improvement of Serum Albumin Level in Cirrhotic Patients With Ascites Unknown status NCT02755701 Phase 4 Branched-chain Amino Acid;Placebo
3 Test Predicting Adrenal Insufficiency in Volunteers Under Prednisone Treatment Completed NCT00975078 Phase 4 prednisone
4 Hydrocortisone Replacement in Patients With Secondary Adrenal Insufficiency (SUPREME CORT) Completed NCT01546922 Phase 4 Hydrocortisone
5 Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM) Completed NCT02277587 Phase 4 Plenadren;Conventional glucocorticoid therapy
6 Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Test Completed NCT00851942 Phase 4 Synacthen (Tetracosactrin)
7 Revival of Stem Cells in Addison's Study Completed NCT01371526 Phase 4 depot tetracosactide
8 Evaluation of Efficacy and Hypothalamus-pituitary-adrenal Axis Suppression Due to Corticosteroids Intrabursal Injection Completed NCT01652495 Phase 4 methylprednisolone acetate;Triamcinolone Acetonide
9 Post Operative Hemodynamic Function After Anesthetic Induction With Etomidate for Cardiac Surgery With ECC Completed NCT00451776 Phase 4 etomidate;propofol
10 The Effect of Moderate-Dose Steroid Therapy in Sepsis Completed NCT01275638 Phase 4 Prednisolone
11 Low-dose Hydrocortisone in Acutely Burned Patients Completed NCT00149123 Phase 4 hydrocortisone 200 mg/day
12 Short-term Prednisone to Treat STA Study(SPTSS) Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
13 Effect of Etomidate on Hemodynamics and Adrenocortical Function After Cardiac Surgery Completed NCT00415701 Phase 4 Etomidate;Propofol;Hydrocortisone;NaCl 0.9%
14 Omega-3 Fatty Acids in Bariatric Gastric Bypass Surgery: Effect on Liver Volume, Immune Response and Erythrocyte Function Completed NCT02206256 Phase 4 Omega-3 fatty acid capsules
15 Steroid Use in Pediatric Fluid and Vasoactive Infusion Dependent Shock - Pilot Study Completed NCT02044159 Phase 4 Hydrocortisone
16 Effectiveness of Escitalopram in Preventing or Reducing Depressive Symptoms in People Receiving Interleukin-2 Treatment Completed NCT00352885 Phase 4 Escitalopram;Placebo;IL-2
17 Taper Or Abrupt Steroid Stop: TOASSTtrial Recruiting NCT03153527 Phase 4 Prednisone
18 Comparison of Two Strategies of Glucocorticoid Withdrawal in Rheumatoid Arthritis Patients Recruiting NCT02997605 Phase 4 GlucoCorticoid
19 Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial Recruiting NCT02643381 Phase 4 Etomidate;Ketamine
20 Efficacy and Safety of Two Glucocorticoid Regimens in the Treatment of Sarcoidosis Recruiting NCT03265405 Phase 4 Low dose prednisolone;Medium dose prednisolone
21 Congenital Adrenal Hyperplasia Once Daily Hydrocortisone Treatment Recruiting NCT03760835 Phase 4 Conventional Glucocorticoids (immediate release hydrocortisone, cortisone acetate, prednisone, prednisolone, dexamethasone);Dual release hydrocortisone (plenadren)
22 Optimising Steroid Replacement in Patients With Adrenal Insufficiency Enrolling by invitation NCT03282487 Phase 4 Modified release hydrocortisone
23 Modified-release Compared to Conventional Hydrocortisone on Diurnal Fatigue in Secondary Hypoadrenalism Enrolling by invitation NCT02282150 Phase 4 Hydrocortisone;Plenadren
24 Comparison of Intramuscular and Intravenous ACTH Stimulation Test in Normal Volunteers Not yet recruiting NCT03752190 Phase 4 Cosyntropin
25 A Study of Markers of Glucocorticoid Effects in Patients With Addisons Disease (DOSCORT) Not yet recruiting NCT03210545 Phase 4 Dexamethasone
26 iKanEat: A Randomized-controlled, Multi-center Trial of Megestrol for Chronic Oral Food Refusal in Children 9 Months to 5 Years 6 Months of Age Not yet recruiting NCT03815019 Phase 4 Megestrol Acetate
27 Adrenal Insufficiency in Septic Shock Terminated NCT00842933 Phase 4 Corticosteroid;Corticosteroid
28 Neuropsychological Effects of Hydrocortisone in Patients With Partial Adrenal Insufficiency Terminated NCT01089075 Phase 4 Hydrocortisone;Placebo
29 Hemodynamic and Inflammatory Effects of Abrupt Versus Tapered Corticosteroid Discontinuation in Septic Shock Terminated NCT01150409 Phase 4 hydrocortisone;Normal Saline
30 Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis Withdrawn NCT00368381 Phase 4 Hydrocortisone
31 The Effect of Dexamethasone on Cortisol Levels in Patients Undergoing Thyroid Surgery Withdrawn NCT01045876 Phase 4 Dexamethasone
32 Septic Shock em Steroids Unknown status NCT01047670 Phase 2, Phase 3 Hydrocortisone
33 Treatment of Adrenal Insufficiency in Children Completed NCT02720952 Phase 3 Infacort®
34 Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency Completed NCT00915343 Phase 2, Phase 3 hydrocortisone (modified release), oral tablet 20 and 5 mg;Hydrocortisone, oral tablet, 10 mg
35 Dehydroepiandrosterone Substitution in Adolescent and Young Women With Central Adrenal Insufficiency Completed NCT00575341 Phase 3 Dehydroepiandrosterone;placebo
36 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Dehydroepiandrosterone Replacement for Primary Adrenal Insufficiency Completed NCT00004313 Phase 3 dehydroepiandrosterone
37 Corticosteroid Therapy for Glucocorticoid Insufficiency Related to Traumatic Brain Injury Completed NCT01093261 Phase 3 Placebo;Hydrocortisone Fludrocortisone
38 PREMILOC Trial to Prevent Bronchopulmonary Dysplasia in Very Preterm Neonates Completed NCT00623740 Phase 3 hydrocortisone;placebo
39 Early Use of Hydrocortisone in Hypotensive Very Low Birth Weight Infants Completed NCT00358748 Phase 3 Hydrocortisone
40 Mepolizumab Steroid-Sparing Study in Subjects With Severe Refractory Asthma Completed NCT01691508 Phase 3 Mepolizumab;Placebo;OCS (prednisone/prednisolone)
41 Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock Completed NCT00320099 Phase 3 recombinant human insulin;hydrocortisone;fludrocortisone;Hydrocortisone
42 Ketamine / Propofol Admixture "Ketofol" at Induction in the Critically Ill Against Etomidate: KEEP PACE Trial Completed NCT02105415 Phase 2, Phase 3 Ketamine / Propofol Admixture;Etomidate
43 Corticosteroid Therapy of Septic Shock - Corticus Completed NCT00147004 Phase 3 hydrocortisone sodium succinate;Placebo
44 Glucocorticoid Treatment in Addison's Disease Completed NCT01063569 Phase 2, Phase 3 Solu-Cortef (hydrocortisone);Cortef (hydrocortisone)
45 MD1003-AMN MD1003 in Adrenomyeloneuropathy Completed NCT02961803 Phase 2, Phase 3 MD1003 100 mg capsule;Placebo
46 Stem Cell Transplant for Inborn Errors of Metabolism Completed NCT00176904 Phase 2, Phase 3 Busulfan, Cyclophosphamide, Antithymocyte Globulin
47 Compassionate Treatment of Patients With Inborn Errors of Bile Acid Metabolism With Cholic Acid Completed NCT00007020 Phase 3 Cholic Acids
48 Is Adrenal Insufficiency Under-diagnosed in Hospitalized Cirrhosis Patients? Recruiting NCT03368066 Phase 3 Cosyntropin
49 PROACT: Can we Prevent Chemotherapy-related Heart Damage in Patients With Breast Cancer? Recruiting NCT03265574 Phase 3 Enalapril
50 Study to Evaluate Efficacy and Safety of Benralizumab in Reducing Oral Corticosteroid Use in Adult Patients With Severe Asthma Recruiting NCT03557307 Phase 3

Search NIH Clinical Center for Hypoadrenalism

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Hypoadrenalism

Anatomical Context for Hypoadrenalism

MalaCards organs/tissues related to Hypoadrenalism:

41
Adrenal Gland, Testes, Pituitary, Brain, Lung, Thyroid, Cortex

Publications for Hypoadrenalism

Articles related to Hypoadrenalism:

(show top 50) (show all 92)
# Title Authors Year
1
Usage of continuous glucose monitoring (CGM) for detecting an unrecognized hypoglycemia and management of glucocorticoid replacement therapy in adult patients with central hypoadrenalism. ( 29618670 )
2018
2
Avelumab inducing hypothyroidism and hypoadrenalism: A case report and review of literature. ( 30034316 )
2018
3
Rare case of meningococcal sepsis-induced testicular failure, primary hypothyroidism and hypoadrenalism: Is there a link? ( 30219775 )
2018
4
Letter to the Editor: Including the Zona Reticularis in the Definition of Hypoadrenalism and Hyperadrenalism. ( 28911156 )
2017
5
Predictability of hypoadrenalism occurrence and duration after adrenalectomy for ACTH-independent hypercortisolism. ( 29151238 )
2017
6
Hypothalamic-Pituitary Axis in Non-Functioning Pituitary Adenomas: Focus on the Prevalence of Isolated Central Hypoadrenalism. ( 25924873 )
2015
7
A Case of Autoimmune Polyglandular Syndrome (APS) Type II with Hypothyroidism, Hypoadrenalism, and Celiac Disease - A Rare Combination. ( 26023582 )
2015
8
Hypoadrenalism secondary to topical corticosteroid-containing skin-lightening cream: danger of over-the-counter cosmetic agents. ( 26424061 )
2015
9
The role of adrenal scintigraphy in the diagnosis of subclinical Cushing's syndrome and the prediction of post-surgical hypoadrenalism. ( 24615601 )
2014
10
Central hypoadrenalism. ( 25140404 )
2014
11
Cortisol: ACTH ratio to test for primary hypoadrenalism: a pilot study. ( 23729816 )
2013
12
Comparison of the overnight metyrapone and glucagon stimulation tests in the assessment of secondary hypoadrenalism. ( 22998100 )
2013
13
The use of an early ACTH test to identify hypoadrenalism-related hypotension in low birth weight infants. ( 22402482 )
2012
14
Is the 250 I1g ACTH test a useful tool for the diagnosis of central hypoadrenalism in adult patients with pituitary disorders? ( 23422765 )
2012
15
Basal cortisol levels and correlates of hypoadrenalism in patients with human immunodeficiency virus infection. ( 21986010 )
2011
16
Hypoadrenalism presenting as a range of mental disorders. ( 22707626 )
2011
17
Painful hypoadrenalism. ( 22700071 )
2011
18
Clinical Review#: The diagnosis and management of central hypoadrenalism. ( 20719838 )
2010
19
Topiramate can induce hypoadrenalism in patients taking oral corticosteroid replacement. ( 19131388 )
2009
20
Musculoskeletal aspects of hypoadrenalism: just a load of aches and pains? ( 19266139 )
2009
21
Metastases with hypoadrenalism: diagnostic parallels and diagnostic traps. ( 20016446 )
2009
22
Hypoadrenalism is not associated with early mortality during tuberculosis treatment in Malawi. ( 18284838 )
2008
23
'Great tan but I feel awful'. Diagnosis: Autoimmune primary hypoadrenalism. ( 18704214 )
2008
24
Secondary hypoadrenalism. ( 18418713 )
2008
25
Hypoadrenalism following trauma: is sepsis always necessary? ( 19079677 )
2008
26
Exacerbation of hepatitis C induced subclinical hypoadrenalism by Interferon-alpha2beta: A case report. ( 18801174 )
2008
27
Doses and steroids to be used in primary and central hypoadrenalism. ( 17651687 )
2007
28
Early hypoadrenalism in premature infants at risk for bronchopulmonary dysplasia or death. ( 17888053 )
2007
29
Corticotrope hypersecretion coupled with cortisol hypo-responsiveness to stimuli is present in patients with autoimmune endocrine diseases: evidence for subclinical primary hypoadrenalism? ( 16914596 )
2006
30
Megestrol acetate induced hypoadrenalism with cushingoid phenotype in endometrial cancer. ( 16414105 )
2006
31
Comparison of different regimens of glucocorticoid replacement therapy in patients with hypoadrenalism. ( 16218046 )
2005
32
Diabetes insipidus, secondary hypoadrenalism and hypothyroidism after traumatic brain injury: clinical implications. ( 16508710 )
2005
33
Effects of dehydroepiandrosterone (DHEA) supplementation on hormonal, metabolic and behavioral status in patients with hypoadrenalism. ( 15636426 )
2004
34
CHARGE association and secondary hypoadrenalism. ( 12567418 )
2003
35
Overt hypoadrenalism is uncommon in patients with stage 3 and 4 bronchogenic carcinoma. ( 14635559 )
2003
36
Adrenal gland hypofunction in active polymyalgia rheumatica. effect of glucocorticoid treatment on adrenal hormones and interleukin 6. ( 11950017 )
2002
37
Cerebral salt wasting syndrome or secondary hypoadrenalism? ( 11433653 )
2001
38
The low dose ACTH stimulation test is less sensitive than the overnight metyrapone test for the diagnosis of secondary hypoadrenalism. ( 10931104 )
2000
39
The low dose ACTH stimulation test is less sensitive than the overnight metyrapone test for the diagnosis of secondary hypoadrenalism. ( 11155100 )
2000
40
Primary hypoadrenalism assessed by the 1 microg ACTH test in hospitalized patients with active pulmonary tuberculosis. ( 10984555 )
2000
41
The role of the low dose ACTH test in the evaluation of central hypoadrenalism. ( 10435862 )
1999
42
Transient hypoadrenalism during surgical critical illness. ( 9484735 )
1998
43
Commentary: hypoadrenalism should also be considered in cases of persistent hyponatraemia. ( 9522797 )
1998
44
Hypercalcemia in an euthyroid patient with secondary hypoadrenalism and diabetes insipidus due to hypothalamic tumor. ( 10395233 )
1998
45
Catastrophic hypoadrenalism in a case of SjAPgren's syndrome. ( 9894388 )
1998
46
Corticotrophic macroadenoma of the pituitary associated with hypoadrenalism. ( 9274709 )
1997
47
Corticotrophic macroadenoma of the pituitary associated with hypoadrenalism. ( 9373445 )
1997
48
Failure of the short ACTH test to unequivocally diagnose long-standing symptomatic secondary hypoadrenalism. ( 8849565 )
1996
49
Diagnosis of secondary hypoadrenalism. ( 8796149 )
1996
50
Hypercalcaemia and secondary hypoadrenalism due to Sheehan's syndrome. ( 8736284 )
1995

Variations for Hypoadrenalism

Expression for Hypoadrenalism

Search GEO for disease gene expression data for Hypoadrenalism.

Pathways for Hypoadrenalism

Pathways related to Hypoadrenalism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.03 CALCA CRH GH1 POMC PTHLH
2 12.03 CALCA PCSK1 POMC
3
Show member pathways
11.83 CALCA CRH PTHLH
4
Show member pathways
11.59 GH1 PCSK1 POMC
5 11.22 GH1 PTHLH
6 11.09 CALCA CRH POMC PTHLH
7 9.8 CRH POMC

GO Terms for Hypoadrenalism

Cellular components related to Hypoadrenalism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 CALCA CRH GH1 PCSK1 POMC PTHLH
2 extracellular region GO:0005576 9.17 CALCA CRH GH1 POMC PTHLH SHBG

Biological processes related to Hypoadrenalism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of blood pressure GO:0008217 9.32 CALCA POMC
2 response to immobilization stress GO:0035902 9.26 CRH CYP1A2
3 cell-cell signaling GO:0007267 9.26 CALCA PCSK1 POMC PTHLH
4 response to pain GO:0048265 9.16 CALCA CRH
5 regulation of signaling receptor activity GO:0010469 9.02 CALCA GH1 POMC PTHLH TG

Molecular functions related to Hypoadrenalism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.1 CALCA CRH GH1 POMC PTHLH TG

Sources for Hypoadrenalism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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