MCID: HYP189
MIFTS: 43

Hypoadrenalism

Categories: Rare diseases, Endocrine diseases

Aliases & Classifications for Hypoadrenalism

MalaCards integrated aliases for Hypoadrenalism:

Name: Hypoadrenalism 53 55
Adrenal Gland Hypofunction 73
Hypoaldosteronism 73

Classifications:



External Ids:

Summaries for Hypoadrenalism

MalaCards based summary : Hypoadrenalism, also known as adrenal gland hypofunction, is related to hypoadrenocorticism, familial and diabetes insipidus. An important gene associated with Hypoadrenalism is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Neuroscience. The drugs Hydrocortisone and Fludrocortisone have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and pituitary, and related phenotypes are adipose tissue and endocrine/exocrine gland

Wikipedia : 76 Adrenal insufficiency is a condition in which the adrenal glands do not produce adequate amounts of... more...

Related Diseases for Hypoadrenalism

Diseases related to Hypoadrenalism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 hypoadrenocorticism, familial 32.1 CRH POMC
2 diabetes insipidus 30.2 CRH POMC
3 functioning pituitary adenoma 30.2 GH1 POMC
4 hypopituitarism 30.0 CRH GH1 POMC
5 amenorrhea 29.8 CRH POMC SHBG
6 hyperthyroidism 28.7 GH1 SHBG TG
7 hypothyroidism 27.4 CALCA GH1 POMC SHBG TG
8 achalasia-addisonianism-alacrima syndrome 11.1
9 proprotein convertase 1/3 deficiency 11.0
10 pituitary carcinoma 10.6 CRH POMC
11 acth deficiency, isolated 10.6 CRH POMC
12 nelson syndrome 10.6 CRH POMC
13 sheehan syndrome 10.6 CRH POMC
14 acth-secreting pituitary adenoma 10.6 CRH POMC
15 fasting hypoglycemia 10.6 CRH POMC
16 adrenal cortical hypofunction 10.6 CRH POMC
17 withdrawal disorder 10.6 CRH POMC
18 adrenal cortex disease 10.6 CRH POMC
19 adrenal gland disease 10.6 CRH POMC
20 ectopic cushing syndrome 10.5 CRH POMC
21 hyperproinsulinemia 10.5 PCSK1 SHBG
22 persistent fetal circulation syndrome 10.5 CRH POMC
23 pituitary-dependent cushing's disease 10.5 CRH POMC
24 endogenous depression 10.5 CRH POMC
25 fetal erythroblastosis 10.5 POMC SHBG
26 cytochrome p450 oxidoreductase deficiency 10.5 CYP1A2 POMC
27 lymphocytic hypophysitis 10.5 GH1 POMC
28 adenohypophysitis 10.5 GH1 POMC
29 sex differentiation disease 10.5 POMC SHBG
30 empty sella syndrome 10.5 GH1 POMC
31 hyperpituitarism 10.4 GH1 POMC
32 mental depression 10.4 CRH POMC
33 adrenal adenoma 10.4 CRH POMC
34 chromophobe adenoma 10.4 GH1 POMC
35 gynecomastia 10.3 POMC SHBG
36 secondary hypertrophic osteoarthropathy 10.3 CALCA POMC
37 adrenal carcinoma 10.3 CRH POMC
38 marasmus 10.3 GH1 SHBG
39 pituitary tumors 10.3 GH1 POMC
40 pituitary hormone deficiency, combined, 2 10.3 GH1 POMC
41 female reproductive system disease 10.3 POMC SHBG
42 hypercalcemia, infantile, 1 10.2 CALCA PTHLH
43 islet cell tumor 10.2 CALCA PTHLH
44 parathyroid gland disease 10.2 CALCA PTHLH
45 premenstrual tension 10.1 CRH POMC SHBG
46 endocrine exophthalmos 10.1 POMC TG
47 thyroid crisis 10.1 POMC TG
48 acquired metabolic disease 10.1 POMC PTHLH SHBG
49 hypothalamic disease 10.1 CRH GH1 POMC
50 hyperandrogenism 10.1 POMC SHBG

Graphical network of the top 20 diseases related to Hypoadrenalism:



Diseases related to Hypoadrenalism

Symptoms & Phenotypes for Hypoadrenalism

MGI Mouse Phenotypes related to Hypoadrenalism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.26 CRH PCSK1 POMC PTHLH
2 endocrine/exocrine gland MP:0005379 9.1 CRH CYP1A2 PCSK1 POMC PTHLH TG

Drugs & Therapeutics for Hypoadrenalism

Drugs for Hypoadrenalism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 237)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-23-7 5754
2
Fludrocortisone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 127-31-1 31378
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 1,Not Applicable 50-02-2 5743
4
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 51-43-4 5816
5
Racepinephrine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 329-65-7 838
6
Etomidate Approved Phase 4,Phase 2,Phase 3,Not Applicable 33125-97-2 36339 667484
7
rituximab Approved Phase 4,Phase 2 174722-31-7 10201696
8
Menthol Approved Phase 4 2216-51-5 16666
9
Celecoxib Approved, Investigational Phase 4,Phase 2 169590-42-5 2662
10
Cortisone acetate Approved, Investigational Phase 4,Not Applicable 1950-04-4, 50-04-4 5745
11
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
12
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
13
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 2078-54-8 4943
14
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
15
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
16
Cosyntropin Approved Phase 4,Phase 3,Not Applicable 16960-16-0 16129617
17
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
18
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
19
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3 6740-88-1 3821
20
Sulfamethazine Approved, Investigational, Vet_approved Phase 4 57-68-1 5327
21 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2
22
Butyric Acid Experimental, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 107-92-6 264
23 Dexamethasone acetate Phase 4,Phase 1,Not Applicable 1177-87-3
24 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25 Respiratory System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
26 Adrenergic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
27 Adrenergic Agonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
28 Adrenergic alpha-Agonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
29 Adrenergic beta-Agonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
30 Adrenocorticotropic Hormone Phase 4,Phase 1,Not Applicable
31 Mydriatics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
32 Cortisol succinate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
33 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
34 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Vasoconstrictor Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
38 Anti-Asthmatic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
39 Hydrocortisone 17-butyrate 21-propionate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
40 Hydrocortisone acetate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
41 Hydrocortisone-17-butyrate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
42 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 Epinephryl borate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
44 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
45 Protective Agents Phase 4,Phase 3,Phase 2,Not Applicable
46 Liver Extracts Phase 4,Phase 3,Phase 2
47 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
48 BB 1101 Phase 4,Phase 1,Not Applicable
49 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
50 Bronchodilator Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 185)
# Name Status NCT ID Phase Drugs
1 Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT00773058 Phase 4 hydrocortisone;placebo
2 Omega-3 Fatty Acids in Bariatric Gastric Bypass Surgery: Effect on Liver Volume, Immune Response and Erythrocyte Function Unknown status NCT02206256 Phase 4 Omega-3 fatty acid capsules
3 Test Predicting Adrenal Insufficiency in Volunteers Under Prednisone Treatment Completed NCT00975078 Phase 4 prednisone
4 Hydrocortisone Replacement in Patients With Secondary Adrenal Insufficiency (SUPREME CORT) Completed NCT01546922 Phase 4 Hydrocortisone
5 Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM) Completed NCT02277587 Phase 4 Plenadren;Conventional glucocorticoid therapy
6 Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Test Completed NCT00851942 Phase 4 Synacthen (Tetracosactrin)
7 Revival of Stem Cells in Addison's Study Completed NCT01371526 Phase 4 depot tetracosactide
8 Evaluation of Efficacy and Hypothalamus-pituitary-adrenal Axis Suppression Due to Corticosteroids Intrabursal Injection Completed NCT01652495 Phase 4 methylprednisolone acetate;Triamcinolone Acetonide
9 Post Operative Hemodynamic Function After Anesthetic Induction With Etomidate for Cardiac Surgery With ECC Completed NCT00451776 Phase 4 etomidate;propofol
10 The Effect of Moderate-Dose Steroid Therapy in Sepsis Completed NCT01275638 Phase 4 Prednisolone
11 Low-dose Hydrocortisone in Acutely Burned Patients Completed NCT00149123 Phase 4 hydrocortisone 200 mg/day
12 Short-term Prednisone to Treat STA Study(SPTSS) Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
13 Effect of Etomidate on Hemodynamics and Adrenocortical Function After Cardiac Surgery Completed NCT00415701 Phase 4 Etomidate;Propofol;Hydrocortisone;NaCl 0.9%
14 Steroid Use in Pediatric Fluid and Vasoactive Infusion Dependent Shock - Pilot Study Completed NCT02044159 Phase 4 Hydrocortisone
15 Rescue of Steroidogenic Capacity in Adrenocortical Failure Study (RADS) Completed NCT00753597 Phase 4 Solu-medrone, Mabthera
16 Taper Or Abrupt Steroid Stop: TOASSTtrial Recruiting NCT03153527 Phase 4 Prednisone
17 Comparison of Two Strategies of Glucocorticoid Withdrawal in Rheumatoid Arthritis Patients Recruiting NCT02997605 Phase 4 GlucoCorticoid
18 Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial Recruiting NCT02643381 Phase 4 Etomidate;Ketamine
19 Corticosteroid Reduction in COPD Recruiting NCT02857842 Phase 4 Prednisolone
20 Efficacy and Safety of Two Glucocorticoid Regimens in the Treatment of Sarcoidosis Recruiting NCT03265405 Phase 4 Low dose prednisolone;Medium dose prednisolone
21 The Effect of Branched-chain Amino Acid on the Improvement of Serum Albumin Level in Cirrhotic Patients With Ascites Recruiting NCT02755701 Phase 4 Branched-chain Amino Acid;Placebo
22 Optimising Steroid Replacement in Patients With Adrenal Insufficiency Enrolling by invitation NCT03282487 Phase 4 Modified release hydrocortisone
23 Modified-release Compared to Conventional Hydrocortisone on Diurnal Fatigue in Secondary Hypoadrenalism Enrolling by invitation NCT02282150 Phase 4 Hydrocortisone;Plenadren
24 A Study of Markers of Glucocorticoid Effects in Patients With Addisons Disease (DOSCORT) Not yet recruiting NCT03210545 Phase 4 Dexamethasone
25 Adrenal Insufficiency in Septic Shock Terminated NCT00842933 Phase 4 Corticosteroid;Corticosteroid
26 Neuropsychological Effects of Hydrocortisone in Patients With Partial Adrenal Insufficiency Terminated NCT01089075 Phase 4 Hydrocortisone;Placebo
27 Hemodynamic and Inflammatory Effects of Abrupt Versus Tapered Corticosteroid Discontinuation in Septic Shock Terminated NCT01150409 Phase 4 hydrocortisone;Normal Saline
28 Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis Withdrawn NCT00368381 Phase 4 Hydrocortisone
29 The Effect of Dexamethasone on Cortisol Levels in Patients Undergoing Thyroid Surgery Withdrawn NCT01045876 Phase 4 Dexamethasone
30 Septic Shock em Steroids Unknown status NCT01047670 Phase 2, Phase 3 Hydrocortisone
31 Treatment of Adrenal Insufficiency in Children Completed NCT02720952 Phase 3 Infacort®
32 Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency Completed NCT00915343 Phase 2, Phase 3 hydrocortisone (modified release), oral tablet 20 and 5 mg;Hydrocortisone, oral tablet, 10 mg
33 Dehydroepiandrosterone Substitution in Adolescent and Young Women With Central Adrenal Insufficiency Completed NCT00575341 Phase 3 Dehydroepiandrosterone;placebo
34 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Dehydroepiandrosterone Replacement for Primary Adrenal Insufficiency Completed NCT00004313 Phase 3 dehydroepiandrosterone
35 Corticosteroid Therapy for Glucocorticoid Insufficiency Related to Traumatic Brain Injury Completed NCT01093261 Phase 3 Placebo;Hydrocortisone Fludrocortisone
36 PREMILOC Trial to Prevent Bronchopulmonary Dysplasia in Very Preterm Neonates Completed NCT00623740 Phase 3 hydrocortisone;placebo
37 Early Use of Hydrocortisone in Hypotensive Very Low Birth Weight Infants Completed NCT00358748 Phase 3 Hydrocortisone
38 Mepolizumab Steroid-Sparing Study in Subjects With Severe Refractory Asthma Completed NCT01691508 Phase 3 Mepolizumab;Placebo;OCS (prednisone/prednisolone)
39 Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock Completed NCT00320099 Phase 3 recombinant human insulin;hydrocortisone;fludrocortisone;Hydrocortisone
40 Corticosteroid Therapy of Septic Shock - Corticus Completed NCT00147004 Phase 3 hydrocortisone sodium succinate;Placebo
41 Glucocorticoid Treatment in Addison's Disease Completed NCT01063569 Phase 2, Phase 3 Solu-Cortef (hydrocortisone);Cortef (hydrocortisone)
42 MD1003-AMN MD1003 in Adrenomyeloneuropathy Completed NCT02961803 Phase 2, Phase 3 MD1003 100 mg capsule;Placebo
43 Stem Cell Transplant for Inborn Errors of Metabolism Completed NCT00176904 Phase 2, Phase 3 Busulfan, Cyclophosphamide, Antithymocyte Globulin
44 Compassionate Treatment of Patients With Inborn Errors of Bile Acid Metabolism With Cholic Acid Completed NCT00007020 Phase 3 Cholic Acids
45 Study to Evaluate Immunogenicity of the Hepatitis B Antigen of the GSK Biologicals' Candidate Malaria Vaccine (257049) Completed NCT01345240 Phase 3
46 Is Adrenal Insufficiency Under-diagnosed in Hospitalized Cirrhosis Patients? Recruiting NCT03368066 Phase 3 Cosyntropin
47 PROACT: Can we Prevent Chemotherapy-related Heart Damage in Patients With Breast Cancer? Recruiting NCT03265574 Phase 3 Enalapril
48 A Clinical Study to Evaluate the Efficacy and Safety of MIN-102 (IMP) in Male AMN Patients. Recruiting NCT03231878 Phase 2, Phase 3 MIN-102;Placebos
49 Extension Study for Patients Entered Into Study Infacort 003 Active, not recruiting NCT02733367 Phase 3 Infacort®
50 Hydrocortisone Treatment In Systemic Low Blood Pressure During Hypothermia in Asphyxiated Newborns Active, not recruiting NCT02700828 Phase 2, Phase 3 Hydrocortisone;Placebo

Search NIH Clinical Center for Hypoadrenalism

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Hypoadrenalism

Anatomical Context for Hypoadrenalism

MalaCards organs/tissues related to Hypoadrenalism:

41
Adrenal Gland, Testes, Pituitary, Brain, Thyroid, Lung, Liver

Publications for Hypoadrenalism

Articles related to Hypoadrenalism:

(show top 50) (show all 92)
# Title Authors Year
1
Usage of continuous glucose monitoring (CGM) for detecting an unrecognized hypoglycemia and management of glucocorticoid replacement therapy in adult patients with central hypoadrenalism. ( 29618670 )
2018
2
Letter to the Editor: Including the Zona Reticularis in the Definition of Hypoadrenalism and Hyperadrenalism. ( 28911156 )
2017
3
Predictability of hypoadrenalism occurrence and duration after adrenalectomy for ACTH-independent hypercortisolism. ( 29151238 )
2017
4
Hypothalamic-Pituitary Axis in Non-Functioning Pituitary Adenomas: Focus on the Prevalence of Isolated Central Hypoadrenalism. ( 25924873 )
2015
5
A Case of Autoimmune Polyglandular Syndrome (APS) Type II with Hypothyroidism, Hypoadrenalism, and Celiac Disease - A Rare Combination. ( 26023582 )
2015
6
Hypoadrenalism secondary to topical corticosteroid-containing skin-lightening cream: danger of over-the-counter cosmetic agents. ( 26424061 )
2015
7
The role of adrenal scintigraphy in the diagnosis of subclinical Cushing's syndrome and the prediction of post-surgical hypoadrenalism. ( 24615601 )
2014
8
Central hypoadrenalism. ( 25140404 )
2014
9
Cortisol: ACTH ratio to test for primary hypoadrenalism: a pilot study. ( 23729816 )
2013
10
Comparison of the overnight metyrapone and glucagon stimulation tests in the assessment of secondary hypoadrenalism. ( 22998100 )
2013
11
Hypoadrenal syndrome in a patient with amyloidosis secondary to familial Mediterranean fever. ( 23365166 )
2013
12
The use of an early ACTH test to identify hypoadrenalism-related hypotension in low birth weight infants. ( 22402482 )
2012
13
Is the 250 I1g ACTH test a useful tool for the diagnosis of central hypoadrenalism in adult patients with pituitary disorders? ( 23422765 )
2012
14
Basal cortisol levels and correlates of hypoadrenalism in patients with human immunodeficiency virus infection. ( 21986010 )
2011
15
Hypoadrenalism presenting as a range of mental disorders. ( 22707626 )
2011
16
Painful hypoadrenalism. ( 22700071 )
2011
17
Clinical Review#: The diagnosis and management of central hypoadrenalism. ( 20719838 )
2010
18
Topiramate can induce hypoadrenalism in patients taking oral corticosteroid replacement. ( 19131388 )
2009
19
Musculoskeletal aspects of hypoadrenalism: just a load of aches and pains? ( 19266139 )
2009
20
Metastases with hypoadrenalism: diagnostic parallels and diagnostic traps. ( 20016446 )
2009
21
Dehydroepiandrosterone replacement therapy in hypoadrenal women: protein anabolism and skeletal muscle function. ( 18990320 )
2008
22
Hypoadrenalism is not associated with early mortality during tuberculosis treatment in Malawi. ( 18284838 )
2008
23
'Great tan but I feel awful'. Diagnosis: Autoimmune primary hypoadrenalism. ( 18704214 )
2008
24
Secondary hypoadrenalism. ( 18418713 )
2008
25
Hypoadrenalism following trauma: is sepsis always necessary? ( 19079677 )
2008
26
Exacerbation of hepatitis C induced subclinical hypoadrenalism by Interferon-alpha2beta: A case report. ( 18801174 )
2008
27
Doses and steroids to be used in primary and central hypoadrenalism. ( 17651687 )
2007
28
Early hypoadrenalism in premature infants at risk for bronchopulmonary dysplasia or death. ( 17888053 )
2007
29
Corticotrope hypersecretion coupled with cortisol hypo-responsiveness to stimuli is present in patients with autoimmune endocrine diseases: evidence for subclinical primary hypoadrenalism? ( 16914596 )
2006
30
Megestrol acetate induced hypoadrenalism with cushingoid phenotype in endometrial cancer. ( 16414105 )
2006
31
Comparison of different regimens of glucocorticoid replacement therapy in patients with hypoadrenalism. ( 16218046 )
2005
32
Effect of dehydroepiandrosterone replacement on insulin sensitivity and lipids in hypoadrenal women. ( 15734854 )
2005
33
Diabetes insipidus, secondary hypoadrenalism and hypothyroidism after traumatic brain injury: clinical implications. ( 16508710 )
2005
34
Effects of dehydroepiandrosterone (DHEA) supplementation on hormonal, metabolic and behavioral status in patients with hypoadrenalism. ( 15636426 )
2004
35
CHARGE association and secondary hypoadrenalism. ( 12567418 )
2003
36
Overt hypoadrenalism is uncommon in patients with stage 3 and 4 bronchogenic carcinoma. ( 14635559 )
2003
37
Adrenal gland hypofunction in active polymyalgia rheumatica. effect of glucocorticoid treatment on adrenal hormones and interleukin 6. ( 11950017 )
2002
38
Cerebral salt wasting syndrome or secondary hypoadrenalism? ( 11433653 )
2001
39
The low dose ACTH stimulation test is less sensitive than the overnight metyrapone test for the diagnosis of secondary hypoadrenalism. ( 10931104 )
2000
40
The low dose ACTH stimulation test is less sensitive than the overnight metyrapone test for the diagnosis of secondary hypoadrenalism. ( 11155100 )
2000
41
Primary hypoadrenalism assessed by the 1 microg ACTH test in hospitalized patients with active pulmonary tuberculosis. ( 10984555 )
2000
42
The role of the low dose ACTH test in the evaluation of central hypoadrenalism. ( 10435862 )
1999
43
Transient hypoadrenalism during surgical critical illness. ( 9484735 )
1998
44
Commentary: hypoadrenalism should also be considered in cases of persistent hyponatraemia. ( 9522797 )
1998
45
Hypercalcemia in an euthyroid patient with secondary hypoadrenalism and diabetes insipidus due to hypothalamic tumor. ( 10395233 )
1998
46
Catastrophic hypoadrenalism in a case of SjAPgren's syndrome. ( 9894388 )
1998
47
Corticotrophic macroadenoma of the pituitary associated with hypoadrenalism. ( 9274709 )
1997
48
Corticotrophic macroadenoma of the pituitary associated with hypoadrenalism. ( 9373445 )
1997
49
Failure of the short ACTH test to unequivocally diagnose long-standing symptomatic secondary hypoadrenalism. ( 8849565 )
1996
50
Diagnosis of secondary hypoadrenalism. ( 8796149 )
1996

Variations for Hypoadrenalism

Expression for Hypoadrenalism

Search GEO for disease gene expression data for Hypoadrenalism.

Pathways for Hypoadrenalism

Pathways related to Hypoadrenalism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.03 CALCA CRH GH1 POMC PTHLH
2 12.03 CALCA PCSK1 POMC
3
Show member pathways
11.83 CALCA CRH PTHLH
4
Show member pathways
11.59 GH1 PCSK1 POMC
5 11.22 GH1 PTHLH
6 11.09 CALCA CRH POMC PTHLH
7 9.8 CRH POMC

GO Terms for Hypoadrenalism

Cellular components related to Hypoadrenalism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CALCA CRH GH1 POMC PTHLH SHBG
2 extracellular space GO:0005615 9.17 CALCA CRH GH1 PCSK1 POMC PTHLH

Biological processes related to Hypoadrenalism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to immobilization stress GO:0035902 9.32 CRH CYP1A2
2 peptide hormone processing GO:0016486 9.26 PCSK1 POMC
3 cell-cell signaling GO:0007267 9.26 CALCA PCSK1 POMC PTHLH
4 response to pain GO:0048265 9.16 CALCA CRH
5 regulation of signaling receptor activity GO:0010469 9.02 CALCA GH1 POMC PTHLH TG

Molecular functions related to Hypoadrenalism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.1 CALCA CRH GH1 POMC PTHLH TG
2 neuropeptide hormone activity GO:0005184 8.96 CRH POMC

Sources for Hypoadrenalism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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