Hypoaldosteronism disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Hypoaldosteronism

MalaCards integrated aliases for Hypoaldosteronism:

Name: Hypoaldosteronism ¹⁹ ⁷⁵ ⁵³ ⁷¹ ³³

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

ICD11: ³³

Endocrine, nutritional or metabolic diseases

Endocrine diseases

Disorders of the adrenal glands or adrenal hormone system

Hypoaldosteronism

External Ids:

ICD11 ³³ 1600625317

UMLS ⁷¹ C0020595

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Summaries for Hypoaldosteronism

GARD: ¹⁹ Hypoaldosteronism is a condition characterized by the shortage (deficiency) or impaired function of a hormone called aldosterone. The symptoms of this condition include low sodium (hyponatremia), too much potassium (hyperkalemia), and a condition where the body produces too much acid (metabolic acidosis). These symptoms may cause muscle weakness, nausea, heart palpitations, irregular heartbeat, and abnormal blood pressure. Hypoaldosteronism may be described as hyporeninemic (low renin level) or hyperreninemic (high renin level) based on the amount of another chemical produced in the kidneys called renin. Hypoaldosteronism can be caused by other health conditions or medications. Individuals with diabetes, kidney disease, primary adrenal insufficiency, lead poisoning, or severe illness can develop Hypoaldosteronism. Certain medications, such as non-steroidal anti-inflammatories, heparin or medications used to treat heart failure can cause Hypoaldosteronism. There are rare forms of congenital Hypoaldosteronism that can be inherited in families. This condition is diagnosed based on the symptoms and confirmed by various blood tests (plasma renin activity, serum aldosterone, and serum cortisol) The exact incidence of Hypoaldosteronism is unknown.

MalaCards based summary: Hypoaldosteronism is related to corticosterone methyloxidase type i deficiency and apparent mineralocorticoid excess. An important gene associated with Hypoaldosteronism is CYP11B2 (Cytochrome P450 Family 11 Subfamily B Member 2), and among its related pathways/superpathways are Peptide hormone metabolism and Metabolism of steroid hormones. The drugs Fludrocortisone and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and adrenal gland, and related phenotypes are renal/urinary system and cardiovascular system

Wikipedia: ⁷⁵ Hypoaldosteronism is an endocrinological disorder characterized by decreased levels of the hormone... more...

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Related Diseases for Hypoaldosteronism

Diseases in the Hypoaldosteronism family:

Familial Hypoaldosteronism	Rare Hypoaldosteronism
Early-Onset Familial Hypoaldosteronism	Late-Onset Familial Hypoaldosteronism

Diseases related to Hypoaldosteronism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 318)

#	Related Disease	Score	Top Affiliating Genes
1	corticosterone methyloxidase type i deficiency	31.6	REN POMC CYP11B2
2	apparent mineralocorticoid excess	31.4	REN POMC CYP11B2
3	microvascular complications of diabetes 3	30.3	REN ACE
4	hypoadrenocorticism, familial	30.1	REN POMC CYP11B2
5	diabetes insipidus	29.9	REN POMC
6	liddle syndrome 1	29.9	REN POMC CYP11B2
7	lipoid congenital adrenal hyperplasia	29.8	REN POMC CYP11B2
8	hypokalemia	29.8	REN POMC CYP11B2 ACE
9	urinary tract infection	29.8	REN ACE
10	chronic kidney disease	29.7	REN NPPA ACE
11	left bundle branch hemiblock	29.6	REN ACE
12	third-degree atrioventricular block	29.5	REN ACE
13	oligohydramnios	29.5	REN ACE
14	urinary tract obstruction	29.5	REN ACE
15	membranoproliferative glomerulonephritis	29.5	REN ACE
16	uremia	29.5	REN ACE
17	acute kidney failure	29.5	REN NPPA ACE
18	iga glomerulonephritis	29.4	REN ACE
19	pure autonomic failure	29.4	REN NPPA ACE
20	hyperaldosteronism, familial, type i	29.4	REN POMC CYP11B2
21	familial glucocorticoid deficiency	29.4	REN POMC CYP11B2
22	adrenal adenoma	29.4	REN POMC CYP11B2
23	adrenal carcinoma	29.4	REN POMC CYP11B2
24	adrenal cortical carcinoma	29.4	REN POMC CYP11B2
25	nephrogenic diabetes insipidus	29.3	REN NPPA
26	nephrotic syndrome	29.3	REN NPPA ACE
27	orthostatic intolerance	29.2	REN POMC ACE
28	conn's syndrome	29.2	REN POMC NPPA CYP11B2 ACE
29	hypothyroidism	29.2	REN POMC ACE
30	pre-eclampsia	28.9	REN NPPA ACE
31	inappropriate adh syndrome	28.6	REN POMC NPPA ACE
32	diabetes mellitus	28.6	REN POMC NPPA ACE
33	hypertension, essential	28.5	REN POMC NPPA CYP11B2 ACE
34	familial hypoaldosteronism	11.3
35	early-onset familial hypoaldosteronism	11.3
36	late-onset familial hypoaldosteronism	11.3
37	corticosterone methyloxidase type ii deficiency	11.3
38	corticosterone methyloxidase deficiency	11.3
39	hyperreninemic hypoaldosteronism, familial, 2	11.2
40	premature ovarian failure 7	11.0
41	pseudohypoaldosteronism	11.0
42	rare hypoaldosteronism	10.9
43	adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete	10.9
44	metabolic acidosis	10.4
45	renal tubular acidosis	10.3
46	microvascular complications of diabetes 4	10.2
47	microvascular complications of diabetes 6	10.2
48	microvascular complications of diabetes 7	10.2
49	glomerulonephritis	10.2
50	kidney disease	10.2

Graphical network of the top 20 diseases related to Hypoaldosteronism:

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Symptoms & Phenotypes for Hypoaldosteronism

MGI Mouse Phenotypes related to Hypoaldosteronism:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system	MP:0005367	9.35	ACE CYP11B2 NPPA POMC REN
2	cardiovascular system	MP:0005385	9.02	ACE CYP11B2 NPPA POMC REN

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Drugs & Therapeutics for Hypoaldosteronism

Drugs for Hypoaldosteronism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Fludrocortisone

Approved, Investigational

Phase 2

127-31-1

31378

2

Anti-Inflammatory Agents

Phase 2

3

Racepinephrine

Approved, Vet_approved

51-43-4, 329-65-7

838 5816

Synonyms:

(−)-(R)-epinephrine

(-)-(R)-Epinephrine

(-)-3,4-Dihydroxy-a-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-a-[(methylamino)methyl]-benzyl alcohol

(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol

(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-alpha-[(methylamino)methyl]-benzyl alcohol

(-)-3,4-DIHYDROXY-ALPHA-[(METHYLAMINO)METHYL]BENZYL ALCOHOL(-)-3,4-DIHYDROXY-ALPHA-[(METHYLAMINO)METHYL]-BENZYL ALCOHOL

(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol

(−)-3,4-dihydroxy-α-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-α-((methylamino)methyl)benzyl alcohol

(-)-Adrenaline

(−)-ADRENALINE

(-)-Epinephrine

(+-)-Adrenaline

(+-)-Epinephrine

(R)-(-)-Adnephrine

(R)-(-)-Adrenaline

(R)-(−)-ADRENALINE

(R)-(-)-Epinephrine

(R)-(-)-Epirenamine

(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

(R)-Adrenaline

(R)-Epinephrine

2-(Methylamino)-1-(3,4-dihydroxyphenyl)ethanol

4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol

4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

4-[(1R)-1-HYDROXY-2-METHYLAMINOETHYL]BENZENE-1,2-DIOL

4-[(1R)-1-HYDROXY-2-METHYLAMINO-ETHYL]BENZENE-1,2-DIOL

4-[(1R)-1-HYDROXY-2-METHYLAMINO-ETHYL]PYROCATECHOL

Acetate, epinephrine

Adnephrine

ADREN CO

ADRENACLICK

Adrenal

Adrenalin

Adrenaline

Adrénaline

Adrenaline acid tartrate

Adrenaline bitartrate

Adrenaline hydrochloride

Adrenaline hydrochloride, racemic mixture

Adrenaline, racemic

Adrenaline, racemic mixture

adrenaline|epinephrine

Adrenine

Adrin

Allergan brand OF adrenaline hydrochloride

ANA-GUARD

Ana-kit

ANAPEN

ANAPHYLACTIC SHOCK DRUG KIT

ASMA-VYDRIN

ASTHMAHALER

Auvi-Q

Bird brand OF racepinefrine hydrochloride

Bosmin

Bronkaid mist

BROVON

Chelafrin

DL-Adrenaline

EMERADE

EPI E Z PEN JR

Epifrin

Epiglaufrin

Epinefrin

Epinefrina

Epinephran

Epinephrin

EPINEPHRINE

Epinephrine acetate

Epinephrine bitartrate

EPINEPHRINE HCL

Epinephrine hydrochloride

Epinephrine hydrochloride, racemic mixture

Epinephrine hydrogen tartrate

Epinephrine racemic

Epinephrine, racemic

Epinephrine, racemic mixture

Epinephrinum

Epipen

EPIPEN E Z PEN

Epipen JR

EPIPEN JR.

Epirenan

Epitrate

Eppy

Exadrin

Glauposine

GPPE INH SOLN

Hemisine

Hemostasin

Hemostatin

Hydrochloride, racepinephrine

Hypernephrin

Isoptoepinal

JEXT

L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol

L-Adrenaline

L-DETHYLAMINOETHANOLCATECHOL

L-Epinephrine

L-Epirenamine

Levoepinephrine

LEVO-METHYLAMINOETHANOLCATECHOL

Levorenen

Levorenin

Levorenine

Levoreninum

L-Methylaminoethanolcatechol

Lyodrin

Lyophrin

Medihaler-epi

Methylarterenol

Micronefrin

Micronephrine

Mixture adrenaline, racemic

Mixture epinephrine, racemic

Mucidrina

Nephridine

Nieraline

NSC-62786

Paranephrin

Primatene

Primatene mist

R-(-)-Epinephrine

Racemic adrenaline

Racemic epinephrine

Racemic mixture adrenaline

Racemic mixture epinephrine

Racepinefrina

Racepinefrine

Racepinefrinum

Racepinephrine

Racepinephrine hydrochloride

Renaglandin

Renaleptine

Renalina

Renoform

Renostypticin

Renostyptin

RIDDOBRON

RIDDOFAN

RYBARVIN

Scurenaline

Simplene

SOLN MADE TO RYBARVIN FOR

Styptirenal

Supracapsulin

Supranephrane

Suprarenaline

Suprarenin

Surrenine

Sus-phrine

SUS-PHRINE SULFITE FREE

SUS-PHRINE SULFITE-FREE

SYMJEPI

Takamina

TWINJECT

TWINJECT 0.15

TWINJECT 0.3

Vaponefrin

Vasoconstrictine

Vasotonin

4

Epinephryl borate

5

Estrogens

6

Mineralocorticoids

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Impact of the Administration of Fludrocortisone on Fluid and Electrolyte Balance in Very Premature Infants: Pilot Study	Completed	NCT03001089	Phase 2	Oral Fludrocortisone (enteral);Placebo Oral Tablet
2	Prospective Evaluation of Adrenal Function After Living Donor Nephrectomy With or Without Ligation of the Adrenal Vein	Completed	NCT00251836
3	Ovarian Follicle Function in Patients With Primary Ovarian Insufficiency	Completed	NCT00001275
4	Investigation of Gene Polymorphisms Influencing Steroid Synthesis and Action in Patients With Deficient Steroid Biosynthesis and Disorders of Sex Development	Withdrawn	NCT00485186

Search NIH Clinical Center for Hypoaldosteronism

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Genetic Tests for Hypoaldosteronism

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Anatomical Context for Hypoaldosteronism

Organs/tissues related to Hypoaldosteronism:

MalaCards : Heart, Kidney, Adrenal Gland, Adrenal Cortex, Pituitary, Bone Marrow, Cortex

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Publications for Hypoaldosteronism

Articles related to Hypoaldosteronism:

(show top 50) (show all 622)

#	Title	Authors	PMID	Year
1	Hyperpotassemia and bradycardia in a bedridden elderly woman with selective hypoaldosteronism associated with low renin activity. ⁵³ ⁶²	Inada M...Hashimoto S	20154436	2010
2	Congenital hyperreninemic hypoaldosteronism in Israel: sequence analysis of CYP11B2 gene. ⁵³ ⁶²	Leshinsky-Silver E...Hanukoglu A	16733366	2006
3	Aldosterone synthase deficiency and related disorders. ⁵³ ⁶²	White PC	15134805	2004
4	A missense mutation (GGC[435Gly]-->AGC[Ser]) in exon 8 of the CYP11B2 gene inherited in Japanese patients with congenital hypoaldosteronism. ⁵³ ⁶²	Kuribayashi I...Shizuta Y	14614232	2003
5	Hyperkalaemia and selective hypoaldosteronism in myotonic dystrophy. ⁵³ ⁶²	Misra D...Nylen ES	11874420	2002
6	Congenital hyperreninemic hypoaldosteronism unlinked to the aldosterone synthase (CYP11B2) gene. ⁵³ ⁶²	Kayes-Wandover KM...White PC	11701710	2001
7	Selective hypoaldosteronism due to combined defects of the conversion from inactive renin to active renin and the aldosterone biosynthesis from corticosterone. ⁵³ ⁶²	Muto S...Asano Y	11423756	2001
8	Genetic analysis of the cytochrome P-450c17alpha (CYP17) and aldosterone synthase (CYP11B2) in Japanese patients with 17alpha-hydroxylase deficiency. ⁵³ ⁶²	Takeda Y...Mabuchi H	11422109	2001
9	Type 1 aldosterone synthase deficiency presenting in a middle-aged man. ⁵³ ⁶²	Kayes-Wandover KM...White PC	11238478	2001
10	Disorders of the aldosterone synthase and steroid 11beta-hydroxylase deficiencies. ⁵³ ⁶²	Peter M...Sippell WG	10559665	1999
11	Homozygous deletion of arginine-173 in the CYP11B2 gene in a girl with congenital hypoaldosteronism. Corticosterone methyloxidase deficiency type II. ⁵³ ⁶²	Peter M...Sippell WG	9838244	1998
12	Changed ratios of glucocorticoids/mineralocorticoids caused by point mutations in the putative I-helix regions of CYP11B1 and CYP11B2. ⁵³ ⁶²	Bottner B...Bernhardt R	8969896	1996
13	Amino acid substitution R384P in aldosterone synthase causes corticosterone methyloxidase type I deficiency. ⁵³ ⁶²	Geley S...Kofler R	7852500	1995
14	The endocrine response to critical illness. ⁵³ ⁶²	Rolih CA...Ober KP	7808093	1995
15	Age-related changes in the renin-aldosterone system. Physiological effects and clinical implications. ⁵³ ⁶²	Bauer JH	8324299	1993
16	Dose effect of adrenocorticotropin on aldosterone and cortisol biosynthesis in cultured bovine adrenal glomerulosa cells: in vitro correlate of hyperreninemic hypoaldosteronism. ⁵³ ⁶²	Braley LM...Williams GH	1319318	1992
17	Heparin-induced hyperkalemia. ⁵³ ⁶²	Aull L...Coy K	2180218	1990
18	Isolated hypoaldosteronism managed by DOCP in a dog with chronic kidney disease and hypercortisolism. ⁶²	Park SM...Youn HY	36106511	2022
19	Systemic Pseudohypoaldosteronism Type 1 Due to a Novel Mutation in SCNN1B Gene: A Case Report. ⁶²	Joshi K...Barman M	36447799	2022
20	Leigh-Like Syndrome With a Novel, Complex Phenotype Due to m.10191T>C in Mt-ND3. ⁶²	Newstead SM...Finsterer J	36249637	2022
21	CIRMI-a new term for a concept worthy of further exploration: a narrative review. ⁶²	Nethathe GD...Feldman C	35813323	2022
22	[Hyperkalemia due to low-molecular-weight heparin]. ⁶²	van der Heiden W...den Exter PL	35736382	2022
23	Early Renin Recovery After Adrenalectomy in Aldosterone-Producing Adenomas: A Prospective Study. ⁶²	Mermejo LM...Moreira AC	35413743	2022
24	An unusual presentation of primary adrenal insufficiency with new onset type 1 diabetes: case report and review of the literature. ⁶²	Graf S...Sunni M	34821121	2022
25	Impaired aldosterone response to ACTH without hypoaldosteronism: An unrecognized secretory pattern in search of clinical implications. ⁶²	Marcus Y...Stern N	34590343	2022
26	Clinical manifestations and associated factors in acquired hypoaldosteronism in endocrinological practice. ⁶²	Ruiz-Sanchez JG...Runkle I	36303866	2022
27	A Novel Frame-Shift Mutation in SCNN1B Identified in a Chinese Family Characterized by Early-Onset Hypertension. ⁶²	Lu YT...Zhou XL	35774371	2022
28	Pseudo-hypoaldosteronism secondary to infantile urinary tract infections: role of ultrasound. ⁶²	Graziano N...Milani GP	35073944	2022
29	Ineffectiveness of Intermittent Hemodialysis in a Critically Ill COVID-19 Patient: A Case of Persistent Heparin-Induced Hyperkalemia. ⁶²	Nlandu YM...Bukabau JB	35284145	2022
30	Excessive Weight Loss in a Neonate - Novel Mutation Causing Primary Hypoaldosteronism. ⁶²	Hussain A...Deshabhotla SK	34939584	2021
31	A rare case of persistent hyperkalaemia. ⁶²	Lewis T...Zouwail S	34159796	2021
32	Persistent hypoaldosteronism post-adrenalectomy for primary aldosteronism - a role for pre-operative spironolactone? ⁶²	Angus LM...Cheung AS	34695011	2021
33	Nephrogenic Syndrome of Inappropriate Antidiuresis Mimicking Hyporeninemic Hypoaldosteronism: Case Report of Two Infants. ⁶²	Mammadova J...Aydin M	34645113	2021
34	Aldosterone signaling defect in young infants: single-center report and review. ⁶²	Wijaya M...Guo S	34243750	2021
35	Cotrimoxazole-induced hyperkalaemia in a patient with known hypoaldosteronism. ⁶²	Montebello A...Gruppetta M	33664032	2021
36	[Low molecular weight heparin-induced hyperkalemia and hyponatremia. Report of one case]. ⁶²	Eymin G	34479277	2021
37	Molecular Analysis of the CYP11B2 Gene in 62 Patients with Hypoaldosteronism Due to Aldosterone Synthase Deficiency. ⁶²	Merakou C...Kanaka-Gantenbein C	33098647	2021
38	COVID-19 and late-onset hypertension with hyporeninaemic hypoaldosteronism. ⁶²	Mandal AKJ...Missouris CG	33078526	2021
39	Case Report: Newborns With Pseudohypoaldosteronism Secondary to Excessive Gastrointestinal Losses Through High Output Stoma. ⁶²	Ou CY...Chia ST	34869126	2021
40	Quality of Life in Men With Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency. ⁶²	Verhees MJM...Claahsen-van der Grinten HL	33815285	2021
41	Liddle Syndrome due to a Novel c.1713 Deletion in the Epithelial Sodium Channel β-Subunit in a Normotensive Adolescent. ⁶²	Brower RK...Vyas AK	33851023	2021
42	Aldosterone deficiency with a hormone profile mimicking pseudohypoaldosteronism. ⁶²	Martin-Rivada A...Martos-Moreno GA	32809961	2020
43	Ibuprofen-Induced Distal Renal Tubular Acidosis and Hyporeninemic Hypoaldosteronism: Enough NSAID. ⁶²	Mandal AKJ...Missouris CG	33012367	2020
44	Primary hypoaldosteronism in a dog with pituitary and adrenal T-cell lymphoma. ⁶²	Beguin JS...Benchekroun G	30390298	2020
45	Metabolic Acidosis, Hyperkalemia, and Renal Unresponsiveness to Aldosterone Syndrome: Response to Treatment with Low-Potassium Diet. ⁶²	Mehandru SK...Vachharajani TJ	33229781	2020
46	Mineralocorticoid Dysfunction during Critical Illness: A Review of the Evidence. ⁶²	Nethathe GD...Feldman C	32501957	2020
47	[Hyperpothemasia and functional hypoaldosteronism after unilateral adrenalectomy for primary hyperaldosteronism in monorrene patient with chronic renal insufficiency]. ⁶²	Calle Garcia L...Fernandez-Reyes Luis MJ	32199859	2020
48	Aldosterone synthase deficiency type II: an unusual presentation of the first Greek case reported with confirmed genetic analysis. ⁶²	Papailiou S...Syggelou A	32857717	2020
49	The First Reported Case of Hyperreninemic Hypoaldosteronism Due to Mucopolysaccharidosis Disorder. ⁶²	Gayed A...Meltzer L	32656005	2020
50	Voriconazole-induced Severe Hyperkalemia Precipitated by Multiple Drug Interactions. ⁶²	Choi JY...Kim GH	32655651	2020

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Genes for Hypoaldosteronism

Genes related to Hypoaldosteronism (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	CYP11B2	Cytochrome P450 Family 11 Subfamily B Member 2	Protein Coding	19.49	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11701710 11422109 16733366 (more) 7852500 11238478 8969896 9838244 15134805 14614232 10559665
2	REN	Renin	Protein Coding	18.05	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11423756 20154436 8324299 (more) 7808093 2180218 11874420
3	ACE	Angiotensin I Converting Enzyme	Protein Coding	7.58	GeneCards inferred via : Publications (show sections)
4	NPPA	Natriuretic Peptide A	Protein Coding	7.4	GeneCards inferred via : Publications (show sections)
5	POMC	Proopiomelanocortin	Protein Coding	5.14	Novoseek inferred ⁵³	1319318

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Variations for Hypoaldosteronism

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Expression for Hypoaldosteronism

Search GEO for disease gene expression data for Hypoaldosteronism.

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Pathways for Hypoaldosteronism

Pathways related to Hypoaldosteronism according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Peptide hormone metabolism ⁶⁶ Show member pathways Glycoprotein hormones ⁶⁶ Metabolism of Angiotensinogen to Angiotensins ⁶⁶ Metabolism of Angiotensinogen to Angiotensins ⁷⁴ Peptide hormone biosynthesis ⁶⁶ Synthesis, secretion, and deacylation of Ghrelin ⁶⁶ thyroid hormone biosynthesis ⁶¹	11.36	REN POMC ACE
2	Metabolism of steroid hormones ⁶⁶ Show member pathways Androgen biosynthesis ⁶⁶ Defective CYP11A1 causes AICSR ⁶⁶ Defective CYP11B1 causes AH4 ⁶⁶ Defective CYP21A2 causes AH3 ⁶⁶ Electron transport from NADPH to Ferredoxin ⁶⁶ Estrogen biosynthesis ⁶⁶ Glucocorticoid and Mineralcorticoid Metabolism ⁷⁴ Glucocorticoid biosynthesis ⁶⁶ Mineralocorticoid biosynthesis ⁶⁶ Pregnenolone biosynthesis ⁶⁶	11.14	POMC CYP11B2
3	ACE Inhibitor Pathway, Pharmacodynamics ⁶⁰ Show member pathways ACE inhibitor pathway ⁷⁴ Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics ⁶⁰ Conversion of angiotensinogen to angiotensin II ⁷⁴ Defective SERPING1 causes hereditary angioedema ⁶⁶ Downregulation of ACE2 by SARS-CoV-2 spike protein ⁷⁴ Kinin-Kallikrein pathway ⁷⁴ Non-classical role of vitamin D ⁷⁴ RAS and bradykinin pathways in COVID-19 ⁷⁴ Renin-angiotensin-aldosterone system (RAAS) ⁷⁴ SARS-CoV-2 and ACE2 receptor: molecular mechanisms ⁷⁴	10.86	REN CYP11B2 ACE

Sources

GO Terms for Hypoaldosteronism

Biological processes related to Hypoaldosteronism according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	amyloid-beta metabolic process	GO:0050435	9.46	REN ACE
2	blood vessel diameter maintenance	GO:0097746	9.43	NPPA ACE
3	angiotensin maturation	GO:0002003	9.26	REN ACE
4	regulation of blood pressure	GO:0008217	9.23	REN POMC NPPA ACE

Sources

Sources for Hypoaldosteronism

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: HYP120 MIFTS: 35	Hypoaldosteronism Categories: Endocrine diseases, Genetic diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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