MCID: HYP121
MIFTS: 49

Hypoalphalipoproteinemia

Categories: Blood diseases, Cardiovascular diseases, Endocrine diseases, Genetic diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Hypoalphalipoproteinemia

MalaCards integrated aliases for Hypoalphalipoproteinemia:

Name: Hypoalphalipoproteinemia 75 59 37 55 40

Classifications:



External Ids:

KEGG 37 H00930
MESH via Orphanet 45 D052456
ICD10 via Orphanet 34 E78.6
UMLS via Orphanet 73 C0473527
Orphanet 59 ORPHA31153

Summaries for Hypoalphalipoproteinemia

KEGG : 37
Hypoalphalipoproteinemia is a common finding in patients with premature coronary artery disease. Familial hypoalphalipoproteinemia syndromes are phenotypically heterogeneous. One form is associated with abnormal cellular cholesterol efflux caused by heterozygous mutations at the ABCA1 gene. Other forms are primary hypoalphalipoproteinemia caused by mutations of APOA1 gene.

MalaCards based summary : Hypoalphalipoproteinemia is related to fish-eye disease and tangier disease. An important gene associated with Hypoalphalipoproteinemia is ABCA1 (ATP Binding Cassette Subfamily A Member 1), and among its related pathways/superpathways are ABC transporters and PPAR signaling pathway. The drugs Nicotinamide and Simvastatin have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and eye, and related phenotypes are corneal opacity and myocardial infarction

Wikipedia : 75 Hypoalphalipoproteinemia is a high-density lipoprotein deficiency, inherited in an autosomal dominant... more...

Related Diseases for Hypoalphalipoproteinemia

Diseases in the Hypoalphalipoproteinemia family:

Hypoalphalipoproteinemia, Primary, 1 Hypoalphalipoproteinemia, Primary, 2

Diseases related to Hypoalphalipoproteinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 fish-eye disease 31.3 LCAT APOA2 APOA1
2 tangier disease 31.0 PLTP LPL LPA LCAT CETP APOE
3 hypolipoproteinemia 30.8 LPL LPA LCAT APOE APOB APOA2
4 familial lcat deficiency 30.7 LCAT APOE APOA2 APOA1
5 coronary artery anomaly 29.7 LPL LPA CETP APOB APOA1
6 hypertriglyceridemia, familial 29.6 LPL LIPC CETP APOE APOC3 APOB
7 arteriosclerosis 28.9 PPARA LPA APOE APOB APOA1
8 cerebrovascular disease 28.9 LDLR APOE APOB APOA1
9 arteries, anomalies of 28.3 LPA LDLR CETP APOE APOB APOA1
10 heart disease 28.1 LPL LDLR APOE APOC3 APOB APOA1
11 hyperlipoproteinemia, type iii 28.0 LPL LPA LIPC LDLR CETP APOE
12 atherosclerosis susceptibility 27.5 PPARA LPA LDLR CETP APOE APOB
13 lecithin:cholesterol acyltransferase deficiency 26.8 LPL LPA LDLR LCAT CETP APOE
14 coronary heart disease 1 26.8 LPL LPA LIPC LDLR LCAT CETP
15 hyperalphalipoproteinemia 1 26.6 PLTP LPL LIPC LDLR LCAT CETP
16 lipid metabolism disorder 26.4 PPARA LPL LPA LIPC LDLR LCAT
17 diabetes mellitus, noninsulin-dependent 26.0 PPARA PLTP LPL LPA LIPC LCAT
18 hypoalphalipoproteinemia, primary, 1 12.8
19 hypoalphalipoproteinemia, primary, 2 12.6
20 apo a-i deficiency 10.6 LCAT APOA1
21 hypercholesterolemia, familial, 1 10.5
22 lipase deficiency, combined 10.4 LPL LIPC
23 eye disease 10.4
24 huntington disease-like 3 10.4
25 huntington disease-like 2 10.4
26 familial lipoprotein lipase deficiency 10.4 LPL LIPC APOC3
27 familial hypercholesterolemia 10.3
28 amyloidosis aa 10.3 LPA LCAT APOA1
29 cerebral atherosclerosis 10.3 APOE APOA1
30 bardet-biedl syndrome 2 10.3 LPL APOC3 APOA1
31 hepatic lipase deficiency 10.3 LPL LIPC APOE APOA1
32 generalized atherosclerosis 10.2 PLTP APOE
33 amyloidosis, familial visceral 10.2 LPA APOA2 APOA1
34 algoneurodystrophy 10.2 LCAT GGT1
35 niemann-pick disease, type b 10.2 LPA LCAT APOA1 ABCA1
36 xanthoma disseminatum 10.1 APOE APOB
37 vitamin e, familial isolated deficiency of 10.1 APOB APOA1 ABCA1
38 fetal macrosomia 10.1 LCAT APOB APOA1
39 hyperlipidemia, familial combined, 3 10.0
40 sarcoidosis 1 10.0
41 afibrinogenemia, congenital 10.0
42 homocystinuria due to cystathionine beta-synthase deficiency 10.0
43 homocysteinemia 10.0
44 langerhans cell histiocytosis 10.0
45 high density lipoprotein cholesterol level quantitative trait locus 14 10.0
46 muscle hypertrophy 10.0
47 chlamydia pneumonia 10.0
48 chlamydia 10.0
49 hyperinsulinism 10.0
50 histiocytosis 10.0

Graphical network of the top 20 diseases related to Hypoalphalipoproteinemia:



Diseases related to Hypoalphalipoproteinemia

Symptoms & Phenotypes for Hypoalphalipoproteinemia

Human phenotypes related to Hypoalphalipoproteinemia:

59 32 (show all 10)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 corneal opacity 59 32 hallmark (90%) Very frequent (99-80%) HP:0007957
2 myocardial infarction 59 32 hallmark (90%) Very frequent (99-80%) HP:0001658
3 angina pectoris 59 32 hallmark (90%) Very frequent (99-80%) HP:0001681
4 transient ischemic attack 59 32 hallmark (90%) Very frequent (99-80%) HP:0002326
5 atherosclerosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0002621
6 xanthelasma 59 32 hallmark (90%) Very frequent (99-80%) HP:0001114
7 abnormal circulating lipid concentration 32 hallmark (90%) HP:0003119
8 sudden cardiac death 59 32 occasional (7.5%) Occasional (29-5%) HP:0001645
9 arrhythmia 59 Occasional (29-5%)
10 abnormality of lipid metabolism 59 Very frequent (99-80%)

GenomeRNAi Phenotypes related to Hypoalphalipoproteinemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.7 ABCA1 APOA1 APOB APOC3 APOE CETP
2 Increased LDL uptake GR00340-A-1 8.92 APOA1 APOE LDLR LPL

MGI Mouse Phenotypes related to Hypoalphalipoproteinemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.27 ABCA1 APOA1 APOA2 APOB APOE BRAF
2 cardiovascular system MP:0005385 10.26 ABCA1 APOA1 APOB APOE BRAF GBA
3 cellular MP:0005384 10.23 ABCA1 APOA1 APOB APOE BRAF GBA
4 endocrine/exocrine gland MP:0005379 10.17 ABCA1 APOA1 APOE BRAF GBA GGT1
5 growth/size/body region MP:0005378 10.14 ABCA1 APOA2 APOB APOE BRAF GBA
6 liver/biliary system MP:0005370 10 ABCA1 APOA1 APOB APOE BRAF GBA
7 integument MP:0010771 9.97 APOA1 APOE BRAF GBA GGT1 LDLR
8 muscle MP:0005369 9.76 ABCA1 APOB APOE BRAF LDLR LPL
9 pigmentation MP:0001186 9.35 APOB APOE BRAF GGT1 LDLR
10 vision/eye MP:0005391 9.17 APOB APOE BRAF GGT1 LCAT LDLR

Drugs & Therapeutics for Hypoalphalipoproteinemia

Drugs for Hypoalphalipoproteinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
2
Simvastatin Approved Phase 4 79902-63-9 54454
3
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
4
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
5 Trace Elements Phase 4
6 Micronutrients Phase 4
7 Vitamins Phase 4
8 Lipid Regulating Agents Phase 4
9 Vitamin B9 Phase 4
10 Folate Phase 4
11 Vitamin B3 Phase 4
12 Vitamin B Complex Phase 4
13 Nicotinic Acids Phase 4
14 Hypolipidemic Agents Phase 4
15 Nutrients Phase 4
16 Vasodilator Agents Phase 4
17 Antimetabolites Phase 4
18 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
19 Anticholesteremic Agents Phase 4
20
Metformin Approved Phase 2, Phase 3 657-24-9 4091 14219
21 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,... Phase 2, Phase 3
22 Sodium-Glucose Transporter 2 Inhibitors Phase 2, Phase 3
23 Hypoglycemic Agents Phase 2, Phase 3
24 Lycopene Approved, Investigational 502-65-8 53477748
25 Tomato Approved

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Short-term Effect of Extended-release Niacin With and Without the Addition of Laropiprant on Endothelial Function Completed NCT01942291 Phase 4 Niacin
2 Magnetic Resonance Characterization of Carotid Atherosclerotic Plaque in Vivo: Effect of High Density Lipoprotein Elevation on Plaque Morphology Completed NCT00307307 Phase 4 Niacin/simvastatin compared to simvastatin alone at 2 doses
3 Effectiveness of the Treatment With Dapagliflozin and Metformin Compared to Metformin Monotherapy for Weight Loss on Diabetic and Prediabetic Patients With Obesity Class III Recruiting NCT03968224 Phase 2, Phase 3 Dapagliflozin/Metformin;Metformin
4 Phase 3, Multicenter, Randomized, 48 Week, Double Blind, Parallel Group, Placebo Controlled Study to Evaluate Efficacy and Safety of CER-001 on Vessel Wall Area in Patients With Genetically Defined Familial Primary Hypoalphalipoproteinemia Terminated NCT02697136 Phase 3 CER-001;Placebo
5 Quantitative Genetic Analysis of Lipid Research Clinic Family Data Completed NCT00005188
6 Hyperapo B and Coronary Heart Disease Completed NCT00005168
7 Effect of Tomato Consumption on Serum High Density Lipoprotein-cholesterol Levels. A Randomized, Open-label, Single Blind, Clinical Trial Completed NCT01342666
8 Apolipoprotein A-I Gene Polymorphism and Atherosclerosis Completed NCT00005183
9 Lipoprotein Metabolism in Normal Volunteers and Hyperlipoproteinemic Patients Recruiting NCT00001154
10 Teaching Protocol for the Evaluation of Plasma Lipoproteins Recruiting NCT00001168

Search NIH Clinical Center for Hypoalphalipoproteinemia

Genetic Tests for Hypoalphalipoproteinemia

Anatomical Context for Hypoalphalipoproteinemia

MalaCards organs/tissues related to Hypoalphalipoproteinemia:

41
Heart, Endothelial, Eye, Liver, Prostate, Kidney, Monocytes

Publications for Hypoalphalipoproteinemia

Articles related to Hypoalphalipoproteinemia:

(show top 50) (show all 279)
# Title Authors PMID Year
1
Functional lecithin: cholesterol acyltransferase is not required for efficient atheroprotection in humans. 9 38
19687369 2009
2
Multiple splice defects in ABCA1 cause low HDL-C in a family with hypoalphalipoproteinemia and premature coronary disease. 9 38
19133158 2009
3
Genetic variation in phospholipid transfer protein modulates lipoprotein profiles in hyperalphalipoproteinemia. 9 38
19013296 2008
4
The ATP-binding cassette transporter A1 R230C variant affects HDL cholesterol levels and BMI in the Mexican population: association with obesity and obesity-related comorbidities. 9 38
17287470 2007
5
A novel haplotype in ABCA1 gene effects plasma HDL-C concentration. 9 38
16806540 2007
6
Genetic variation of PLTP modulates lipoprotein profiles in hypoalphalipoproteinemia. 9 38
16388083 2006
7
[The role of transmembrane lipidtransporter molecules in the atherosclerotic process]. 9 38
16610615 2006
8
Combined monogenic hypercholesterolemia and hypoalphalipoproteinemia caused by mutations in LDL-R and LCAT genes. 9 38
16115486 2005
9
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus. 9 38
16121806 2005
10
Inherited disorders of HDL metabolism and atherosclerosis. 9 38
15767853 2005
11
Severe hypoalphalipoproteinemia in mice expressing human hepatic lipase deficient in binding to heparan sulfate proteoglycan. 9 38
15292235 2004
12
[Mechanisms of hypo and hyper alphalipoproteinemia in Chilean adults]. 9 38
15382513 2004
13
Mechanisms of HDL deficiency in mice overexpressing human apoA-II. 9 38
12364558 2002
14
Gene-drug interaction: additive influence of mutant APOA1 and testosterone on plasma HDL-cholesterol. 9 38
12270762 2002
15
Proteolytic degradation and impaired secretion of an apolipoprotein A-I mutant associated with dominantly inherited hypoalphalipoproteinemia. 9 38
11292828 2001
16
Analysis of glomerulosclerosis and atherosclerosis in lecithin cholesterol acyltransferase-deficient mice. 9 38
11278414 2001
17
The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux. 9 38
11279031 2001
18
Regulation of lipid and lipoprotein metabolism by PPAR activators. 9 38
10774955 2000
19
Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor RORalpha. 9 38
9851961 1998
20
Correction of hypoalphalipoproteinemia in LDL receptor-deficient rabbits by lecithin:cholesterol acyltransferase. 9 38
9717715 1998
21
Molecular genetic study of Finns with hypoalphalipoproteinemia and hyperalphalipoproteinemia: a novel Gly230 Arg mutation (LCAT[Fin]) of lecithin:cholesterol acyltransferase (LCAT) accounts for 5% of cases with very low serum HDL cholesterol levels. 9 38
9555865 1998
22
Genetic polymorphisms and mutations of the lipoprotein lipase gene in Japanese schoolchildren with hypoalphalipoproteinemia. 9 38
9730139 1998
23
High density lipoprotein and coronary heart disease: insights from mutations leading to low high density lipoprotein. 9 38
9253538 1997
24
A natural apolipoprotein A-I variant, apoA-I (L141R)Pisa, interferes with the formation of alpha-high density lipoproteins (HDL) but not with the formation of pre beta 1-HDL and influences efflux of cholesterol into plasma. 9 38
9215551 1997
25
Heterogeneity at the CETP gene locus. Influence on plasma CETP concentrations and HDL cholesterol levels. 9 38
9102177 1997
26
Two novel point mutations in the lecithin:cholesterol acyltransferase (LCAT) gene resulting in LCAT deficiency: LCAT (G873 deletion) and LCAT (Gly344-->Ser). 9 38
8656071 1995
27
Mutations in the gene for lipoprotein lipase. A cause for low HDL cholesterol levels in individuals heterozygous for familial hypercholesterolemia. 9 38
7583547 1995
28
Bimodal distribution of cholesteryl ester transfer protein activities in normotriglyceridemic men with low HDL cholesterol concentrations. 9 38
7749855 1995
29
Microsomal enzyme inducers raise plasma high-density lipoprotein cholesterol levels in healthy control subjects but not in patients with primary hypoalphalipoproteinemia. 9 38
7712672 1995
30
Prevalence of alleles encoding defective lipoprotein lipase in hypertriglyceridemic patients of French Canadian descent. 9 38
7706936 1995
31
Autosomal dominant hypoalphalipoproteinemia due to a completely defective apolipoprotein A-I gene. 9 38
8240372 1993
32
The rs2066808 Polymorphism Located Near the IL-23A Gene Is Associated with Premature Coronary Artery Disease in Mexican Population (GEA Study). 38
31237437 2019
33
Paraoxonase-1 activities in individuals with different HDL circulating levels: Implication in reverse cholesterol transport and early vascular damage. 38
31029939 2019
34
Identification and functional analysis of missense mutations in the lecithin cholesterol acyltransferase gene in a Chilean patient with hypoalphalipoproteinemia. 38
31164121 2019
35
Selective Correction of Genotype Yield by Probucol in HDL-Deficient Mice Propagation. 38
31092744 2019
36
Progress in finding pathogenic DNA copy number variations in dyslipidemia. 38
30664016 2019
37
HIV disease, metabolic dysfunction and atherosclerosis: A three year prospective study. 38
30998801 2019
38
Association between chronic hepatitis B infection and metabolic syndrome. 38
30918858 2018
39
Identification of the first Tangier disease patient in Lebanon carrying a new pathogenic variant in ABCA1. 38
30361172 2018
40
Relation of High-Density Lipoprotein Charge Heterogeneity, Cholesterol Efflux Capacity, and the Expression of High-Density Lipoprotein-Related Genes in Mononuclear Cells to the HDL-Cholesterol Level. 38
30430582 2018
41
Large-scale deletions of the ABCA1 gene in patients with hypoalphalipoproteinemia. 38
29866657 2018
42
Hypoalphalipoproteinemia and BRAFV600E Mutation Are Major Predictors of Aortic Infiltration in the Erdheim-Chester Disease. 38
29930009 2018
43
A novel homozygous ABCA1 variant in an asymptomatic man with profound hypoalphalipoproteinemia. 38
29773422 2018
44
Hepatic Overexpression of Endothelial Lipase Lowers High-Density Lipoprotein but Maintains Reverse Cholesterol Transport in Mice: Role of Scavenger Receptor Class B Type I/ATP-Binding Cassette Transporter A1-Dependent Pathways. 38
29748333 2018
45
ATP-binding cassette transporter A1: A promising therapy target for prostate cancer. 38
29399345 2018
46
Lipidomics Analysis of Behavioral Variant Frontotemporal Dementia: A Scope for Biomarker Development. 38
29541056 2018
47
Association between cardiorespiratory fitness and metabolic risk factors in a population with mild to severe obesity. 38
29435350 2018
48
Association of leptin with cardiometabolic factors in schoolchildren and adolescents with congenital adrenal hyperplasia. 38
29733056 2018
49
Structural determinants in ApoA-I amyloidogenic variants explain improved cholesterol metabolism despite low HDL levels. 38
28887204 2017
50
The association between serum 25-hydroxyvitamin D3 concentration and serum lipids in the rural population of China. 38
29137635 2017

Variations for Hypoalphalipoproteinemia

Expression for Hypoalphalipoproteinemia

Search GEO for disease gene expression data for Hypoalphalipoproteinemia.

Pathways for Hypoalphalipoproteinemia

Pathways related to Hypoalphalipoproteinemia according to KEGG:

37
# Name Kegg Source Accession
1 ABC transporters hsa02010
2 PPAR signaling pathway hsa03320
3 Fat digestion and absorption hsa04975
4 Vitamin digestion and absorption hsa04977

Pathways related to Hypoalphalipoproteinemia according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 SLC25A20 RORA PPARA PLTP LPL LPA
2
Show member pathways
12.77 SLC25A20 RORA PPARA LPL APOA2 APOA1
3
Show member pathways
12.58 LPL LDLR APOE APOC3 APOB APOA2
4
Show member pathways
12.24 LPL LDLR APOE APOC3 APOB APOA2
5
Show member pathways
12.22 LDLR GGT1 APOE APOB APOA1 ABCA1
6
Show member pathways
11.97 PLTP LPL LPA LIPC LDLR LCAT
7
Show member pathways
11.84 PLTP LPL LPA LIPC LDLR LCAT
8
Show member pathways
11.73 APOE APOB APOA1
9 11.68 PPARA PLTP LPL APOC3 APOA2 APOA1
10
Show member pathways
11.42 SLC25A20 LPL LIPC
11
Show member pathways
11.33 APOB APOA1 ABCA1
12 11.07 PPARA PLTP APOC3 APOA2 APOA1
13 10.95 PPARA LDLR ABCA1
14 10.93 APOA2 APOA1 ABCA1

GO Terms for Hypoalphalipoproteinemia

Cellular components related to Hypoalphalipoproteinemia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.91 LIPC APOE APOB APOA2 APOA1
2 early endosome GO:0005769 9.91 LDLR APOE APOC3 APOB APOA2 APOA1
3 clathrin-coated endocytic vesicle membrane GO:0030669 9.67 LDLR APOE APOB
4 endocytic vesicle lumen GO:0071682 9.63 APOE APOB APOA1
5 very-low-density lipoprotein particle GO:0034361 9.63 LPL APOE APOC3 APOB APOA2 APOA1
6 low-density lipoprotein particle GO:0034362 9.62 LDLR APOE APOB APOA1
7 spherical high-density lipoprotein particle GO:0034366 9.58 APOC3 APOA2 APOA1
8 intermediate-density lipoprotein particle GO:0034363 9.56 APOE APOC3 APOB APOA1
9 discoidal high-density lipoprotein particle GO:0034365 9.52 APOE APOA1
10 chylomicron GO:0042627 9.43 LPL APOE APOC3 APOB APOA2 APOA1
11 high-density lipoprotein particle GO:0034364 9.17 PLTP LIPC LCAT CETP APOE APOA2
12 extracellular region GO:0005576 10.22 PLTP LPL LPA LIPC LCAT CETP
13 extracellular exosome GO:0070062 10.19 LCAT GGT1 GBA CETP APOE APOC3
14 extracellular space GO:0005615 10.15 PLTP LPL LIPC LCAT GGT1 GBA

Biological processes related to Hypoalphalipoproteinemia according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Name GO ID Score Top Affiliating Genes
1 low-density lipoprotein particle remodeling GO:0034374 9.99 LPA LIPC CETP APOE APOB APOA2
2 lipid catabolic process GO:0016042 9.98 LPL LIPC APOC3 APOB
3 phospholipid efflux GO:0033700 9.97 APOE APOC3 APOA2 APOA1 ABCA1
4 chylomicron assembly GO:0034378 9.97 APOE APOC3 APOB APOA2 APOA1
5 high-density lipoprotein particle remodeling GO:0034375 9.97 PLTP LIPC LCAT CETP APOE APOC3
6 regulation of lipid metabolic process GO:0019216 9.96 PPARA APOA2 APOA1 ABCA1
7 chylomicron remnant clearance GO:0034382 9.96 LIPC LDLR APOE APOC3 APOB
8 very-low-density lipoprotein particle remodeling GO:0034372 9.95 LPL LIPC LCAT CETP APOE APOA1
9 chylomicron remodeling GO:0034371 9.93 LPL APOE APOC3 APOB APOA2 APOA1
10 high-density lipoprotein particle assembly GO:0034380 9.92 APOE APOA2 APOA1 ABCA1
11 lipoprotein biosynthetic process GO:0042158 9.92 LCAT APOE APOB APOA1 ABCA1
12 cholesterol transport GO:0030301 9.92 LIPC LDLR LCAT CETP APOB APOA2
13 high-density lipoprotein particle clearance GO:0034384 9.91 LDLR APOE APOA2 APOA1
14 cholesterol metabolic process GO:0008203 9.91 LIPC LDLR LCAT CETP APOE APOB
15 phospholipid metabolic process GO:0006644 9.9 LPL LCAT APOA1
16 response to estrogen GO:0043627 9.89 GBA APOA2 APOA1
17 regulation of Cdc42 protein signal transduction GO:0032489 9.89 APOE APOC3 APOA1 ABCA1
18 negative regulation of neuron death GO:1901215 9.88 PPARA GBA APOE
19 phosphatidylcholine biosynthetic process GO:0006656 9.85 LCAT APOA2 APOA1
20 lipid transport GO:0006869 9.85 PLTP LPA LDLR CETP APOE APOC3
21 positive regulation of cholesterol efflux GO:0010875 9.83 PLTP APOE ABCA1
22 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.83 PPARA CETP ABCA1
23 regulation of protein metabolic process GO:0051246 9.83 LDLR GBA APOE
24 phospholipid homeostasis GO:0055091 9.82 CETP APOA1 ABCA1
25 positive regulation of cholesterol esterification GO:0010873 9.82 APOE APOA2 APOA1
26 negative regulation of very-low-density lipoprotein particle remodeling GO:0010903 9.81 APOC3 APOA2 APOA1
27 lipoprotein catabolic process GO:0042159 9.8 LDLR APOE APOB
28 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.73 LPL APOB
29 positive regulation of lipid biosynthetic process GO:0046889 9.73 APOE APOA1
30 negative regulation of lipid catabolic process GO:0050995 9.73 APOC3 APOA2
31 regulation of cholesterol metabolic process GO:0090181 9.73 LDLR APOE
32 cholesterol homeostasis GO:0042632 9.73 RORA LPL LIPC LDLR LCAT CETP
33 phosphatidylcholine metabolic process GO:0046470 9.72 LCAT CETP
34 very-low-density lipoprotein particle assembly GO:0034379 9.72 APOC3 APOB
35 regulation of lipoprotein lipase activity GO:0051004 9.72 LPL LIPC
36 negative regulation of cholesterol storage GO:0010887 9.71 PPARA ABCA1
37 regulation of cholesterol transport GO:0032374 9.71 APOE APOA1
38 positive regulation of cholesterol storage GO:0010886 9.71 LPL APOB
39 very-low-density lipoprotein particle clearance GO:0034447 9.7 APOE APOB
40 peptidyl-methionine modification GO:0018206 9.7 APOA2 APOA1
41 negative regulation of cytokine secretion involved in immune response GO:0002740 9.7 APOA2 APOA1
42 negative regulation of cellular protein metabolic process GO:0032269 9.69 GBA APOE
43 cholesterol import GO:0070508 9.69 LDLR APOA1
44 regulation of intestinal cholesterol absorption GO:0030300 9.69 APOA2 APOA1
45 protein oxidation GO:0018158 9.68 APOA2 APOA1
46 negative regulation of lipase activity GO:0060192 9.68 APOA2 APOA1
47 response to caloric restriction GO:0061771 9.67 LDLR APOE
48 regulation of high-density lipoprotein particle assembly GO:0090107 9.67 LCAT ABCA1
49 negative regulation of cholesterol import GO:0060621 9.67 APOC3 APOA2
50 lipid metabolic process GO:0006629 9.47 PPARA PLTP LPL LPA LIPC LDLR

Molecular functions related to Hypoalphalipoproteinemia according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.91 LPL LPA LIPC APOE APOB
2 phospholipid binding GO:0005543 9.8 APOE APOC3 APOB APOA2 APOA1 ABCA1
3 lipid binding GO:0008289 9.8 PPARA PLTP CETP APOE APOC3 APOA2
4 amyloid-beta binding GO:0001540 9.75 LDLR APOE APOA1
5 phospholipid transporter activity GO:0005548 9.73 PLTP CETP APOA1 ABCA1
6 phosphatidylcholine binding GO:0031210 9.71 PLTP CETP APOA2
7 high-density lipoprotein particle binding GO:0008035 9.67 APOA2 APOA1 ABCA1
8 apolipoprotein binding GO:0034185 9.67 LPL LPA LIPC ABCA1
9 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.65 APOE APOA2 APOA1
10 lipase inhibitor activity GO:0055102 9.63 APOC3 APOA2 APOA1
11 cholesterol binding GO:0015485 9.63 CETP APOE APOC3 APOA2 APOA1 ABCA1
12 transcription coactivator binding GO:0001223 9.6 RORA PPARA
13 phospholipase activity GO:0004620 9.59 LPL LIPC
14 low-density lipoprotein particle binding GO:0030169 9.58 LIPC LDLR
15 high-density lipoprotein particle receptor binding GO:0070653 9.58 APOC3 APOA2 APOA1
16 lipoprotein particle binding GO:0071813 9.57 APOE APOA1
17 apolipoprotein A-I binding GO:0034186 9.56 LCAT ABCA1
18 apolipoprotein receptor binding GO:0034190 9.55 APOA2 APOA1
19 triglyceride binding GO:0017129 9.52 LPL CETP
20 cholesterol transporter activity GO:0017127 9.43 CETP APOE APOB APOA2 APOA1 ABCA1
21 lipid transporter activity GO:0005319 9.17 PLTP CETP APOE APOB APOA2 APOA1

Sources for Hypoalphalipoproteinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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