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MCID: HYP781
MIFTS: 54

Hypoascorbemia

Categories: Endocrine diseases, Metabolic diseases, Rare diseases, Skin diseases
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Aliases & Classifications for Hypoascorbemia

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MalaCards integrated aliases for Hypoascorbemia:

Name: Hypoascorbemia 57 19 75
Scurvy 57 11 19 75 43 14 16 71 33
Ascorbic Acid Deficiency 71 31 33
Vitamin C Deficiency 19 33
Vitamin C, Inability to Synthesize 57
Deficiency of Vitamin C 19
Scorbutus 19
Vitamin C 41

Characteristics:


Inheritance:

Autosomal recessive 57

OMIM®:

57 (Updated 08-Dec-2022)
Miscellaneous:
homo sapiens do not have a functional l-gulonolactone oxidase gene


Classifications:

MalaCards categories:
Global: Rare diseases Metabolic diseases
Anatomical: Endocrine diseases Skin diseases
See all MalaCards categories (disease lists)
ICD10: 31
ICD11: 33


External Ids:

Disease Ontology 11 DOID:13724
OMIM® 57 240400
MeSH 43 D012614
NCIt 49 C35010
SNOMED-CT 68 267493006
ICD10 31 E54
MedGen 40 C0036474
UMLS 71 C0003969 C0036474
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Summaries for Hypoascorbemia

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MedlinePlus: 41 Vitamins are substances that your body needs to grow and develop normally. Vitamin C is an antioxidant. It is important for your skin, bones, and connective tissue. It promotes healing and helps the body absorb iron. Vitamin C comes from fruits and vegetables. Good sources include citrus, red and green peppers, tomatoes, broccoli, and greens. Some juices and cereals have added vitamin C. Some people may need extra vitamin C: Pregnant/breastfeeding women Smokers People recovering from surgery Burn victims

MalaCards based summary: Hypoascorbemia, also known as scurvy, is related to glucosephosphate dehydrogenase deficiency and alcohol use disorder, and has symptoms including fatigue An important gene associated with Hypoascorbemia is GULOP (Gulonolactone (L-) Oxidase, Pseudogene), and among its related pathways/superpathways is Cellular hexose transport. The drugs Hyaluronic acid and Atorvastatin have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and lung, and related phenotypes are abnormality of metabolism/homeostasis and homeostasis/metabolism

GARD: 19 Scurvy is a condition that develops in people who do not consume an adequate amount of vitamin C in their diet. Although Scurvy is relatively rare in the United States, it continues to be a problem in malnourished populations around the world (such as impoverished, underdeveloped third world countries). Early features of the condition include general weakness, fatigue and aching limbs.

Disease Ontology: 11 A nutritional deficiency disease that is characterized by vitamin C (ascorbic acid) deficiency and has symptom fatigue, weakness, anemia, petechiae, corkscrew hair, gingivitis, and poor wound healing.

Wikipedia: 75 Scurvy is a disease resulting from a lack of vitamin C (ascorbic acid). Early symptoms of deficiency... more...

More information from OMIM: 240400
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Related Diseases for Hypoascorbemia

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Diseases related to Hypoascorbemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1090)
# Related Disease Score Top Affiliating Genes
1 glucosephosphate dehydrogenase deficiency 30.5 SLC23A2 CRP ALB
2 alcohol use disorder 30.5 CRP ALB AKR1A1
3 intestinal tuberculosis 30.0 CRP ALB
4 actinomycosis 30.0 CRP ALB
5 tuberculous peritonitis 29.8 CRP ALB
6 bell's palsy 29.8 CRP ALB
7 renal tuberculosis 29.8 CRP ALB
8 marasmus 29.8 CRP ALB
9 thrombocytosis 29.7 TET2 CRP ALB
10 brain edema 29.5 SLC2A3 CRP ALB
11 hypoglycemia 29.2 SLC2A3 SLC2A1 DBH ALB
12 iron overload in africa 11.2
13 tyrosinemia 11.2
14 osmotic diarrhea 11.0
15 tatton-brown-rahman syndrome 10.6
16 purpura 10.5
17 deficiency anemia 10.5
18 pre-eclampsia 10.5
19 rickets 10.5
20 nutritional deficiency disease 10.5
21 helicobacter pylori infection 10.5
22 covid-19 10.5
23 autism spectrum disorder 10.4
24 cataract 10.4
25 pneumonia 10.4
26 autism 10.4
27 severe acute respiratory syndrome 10.4
28 exanthem 10.4
29 adult respiratory distress syndrome 10.4
30 cardiovascular system disease 10.4
31 oto-palatal-digital syndrome 10.4
32 eclampsia 10.4
33 primary hyperoxaluria 10.4
34 rapidly involuting congenital hemangioma 10.3
35 type 1 diabetes mellitus 10.3
36 ischemia 10.3
37 atrophic gastritis 10.3
38 congenital hemidysplasia with ichthyosiform erythroderma and limb defects 10.3
39 gingivitis 10.3
40 vasculitis 10.3
41 asthma 10.3
42 dermatitis 10.3
43 viral infectious disease 10.3
44 alcohol dependence 10.3
45 children's interstitial lung disease 10.3
46 colorectal cancer 10.3
47 melanoma 10.3
48 megaloblastic anemia 10.3
49 cerebral palsy 10.3
50 gingival overgrowth 10.3

Graphical network of the top 20 diseases related to Hypoascorbemia:



Diseases related to Hypoascorbemia
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Symptoms & Phenotypes for Hypoascorbemia

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Human phenotypes related to Hypoascorbemia:

30
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of metabolism/homeostasis 30 HP:0001939

Symptoms via clinical synopsis from OMIM®:

57 (Updated 08-Dec-2022)
Laboratory Abnormalities:
hypoascorbemia
l-gulonolactone oxidase deficiency

Clinical features from OMIM®:

240400 (Updated 08-Dec-2022)

Symptoms:

11
  • • fatigue

MGI Mouse Phenotypes related to Hypoascorbemia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.86 AKR1A1 ALB CRP DBH ERO1B GULOP
2 mortality/aging MP:0010768 9.47 AKR1A1 ALB DBH GULOP PAM RGN
Sources

Drugs & Therapeutics for Hypoascorbemia

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Drugs for Hypoascorbemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 178)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
2
Atorvastatin Approved Phase 4 134523-00-5 60823
3
Iron Approved Phase 4 7439-89-6 29936
4
Tocopherol Approved, Investigational Phase 4 1406-66-2
5
Ferrous succinate Approved Phase 4 10030-90-7
6
Morphine Approved, Investigational Phase 4 57-27-2 5288826
7
Hydrocortisone succinate Approved Phase 4 2203-97-6 3643
8
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
9
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 3640 5754
10
Cathine Approved, Experimental, Illicit, Vet_approved, Withdrawn Phase 4 14838-15-4, 492-39-7 131954576 4786 26934
11
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
12
Ascorbic acid Approved, Nutraceutical Phase 4 50-81-7 54676860 54670067 5785
13
DL-alpha-Tocopherol Approved, Experimental, Investigational, Nutraceutical, Vet_approved Phase 4 59-02-9, 10191-41-0 2116 14985
14
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
15
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
16
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 70-16-6 1130
17
Quercetin Experimental, Investigational Phase 4 117-39-5 10283929 5320834 5280343
18
Tocotrienol Investigational Phase 4 6829-55-6 9929901
19 Hormones Phase 4
20 Hypolipidemic Agents Phase 4
21 Lipid Regulating Agents Phase 4
22 Adjuvants, Immunologic Phase 4
23 Viscosupplements Phase 4
24 Calcium, Dietary Phase 4
25 calcium channel blockers Phase 4
26 Anticholesteremic Agents Phase 4
27 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
28 Vitamins Phase 4
29 Trace Elements Phase 4
30 Antioxidants Phase 4
31 Micronutrients Phase 4
32 Protective Agents Phase 4
33 Tocotrienols Phase 4
34 Tocopherols Phase 4
35 Hematinics Phase 4
36
Epoetin Alfa Phase 4
37 Chrysarobin Phase 4
38 Analgesics, Opioid Phase 4
39 Liver Extracts Phase 4
40 Folate Phase 4
41 Vitamin B9 Phase 4
42 Vitamin B Complex Phase 4
43 Vitamin B1 Phase 4
44 Hydrocortisone 17-butyrate 21-propionate Phase 4
45 Thiamin Phase 4
46 Anti-Inflammatory Agents Phase 4
47 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
48
Calcium Nutraceutical Phase 4 7440-70-2 271
49
Deferiprone Approved Phase 2, Phase 3 30652-11-0 2972
50
Echinacea Approved, Experimental Phase 3

Interventional clinical trials:

(show top 50) (show all 227)
# Name Status NCT ID Phase Drugs
1 The Impact of Vitamin C on Postoperative Acute Kidney Injury in Risk Patients Undergoing Valvular Heart Surgery Unknown status NCT04210453 Phase 4 Vitamin C;Control (Normal saline)
2 The Effect Of Hyaluronic Acid And Melatonin With Systemic Administration of Vitamin C On Implant Stability After Immediate Implant Placement in Anterior and Premolar Region in Systemically Healthy Patients Unknown status NCT03804177 Phase 4
3 Randomized Placebo Controlled Trial of Postoperative Pain After Intravenous Vitamin C Injection for Arthroscopic Rotator Cuff Repair Unknown status NCT02992028 Phase 4 Intravenous Nutrition (Vitamins) injection;Intravenous Saline injection
4 Effect of Vitamin C Infusion on Coronary Reperfusion Indexes Unknown status NCT01090895 Phase 4 Vitamin C;Placebo
5 Effects of Long-term Vitamin C+E and Statin Therapy on Vasospasm Improvement and Regression of Atheroma in Patients With Variant Angina Unknown status NCT03228238 Phase 4 Vitamin C and Vitamin E;Statin;Standard medication for variant angina
6 The Study of Quadruple Therapy Zinc, Quercetin, Bromelain and Vitamin C on the Clinical Outcomes of Patients Infected With COVID-19 Unknown status NCT04468139 Phase 4 Quercetin;Zinc;Vitamin C
7 Effects of Vitamin C, Thiamine and Hydrocortisone in Septic Shock: a Randomized, Controlled Trial Unknown status NCT04039815 Phase 4 Ascorbic acid-Vitamin B1-Hydrocortisone;Placebo
8 The Effect of a Nutrient Fortified Oat Drink on Iron, Zinc, Vitamin A, and Vitamin C Status Among Filipino Children Unknown status NCT01418898 Phase 4
9 The Efficacy and Safety of Vitamin C for Iron Supplementation Therapy in Adult Patients With Iron Deficiency Anemia(IDA) Completed NCT02631668 Phase 4 ferrous succinate and vitamin C;ferrous succinate
10 Assessment of the Effect of Vitamin C on Anemia in Patients With Continuous Ambulatory Peritoneal Dialysi Completed NCT02780505 Phase 4 vitamin c;placebo
11 Effects of Vitamin C and E on Endothelial Function in Adolescent Diabetes Completed NCT02019186 Phase 4
12 Effect of Low Doses of Vitamin C on Salivary Cortisol , Heart Rate , Blood Pressure During Group Presentation Completed NCT04135378 Phase 4 ascorbic acid
13 Comparison Of The Effects Of Preoperative Melatonin Or Vitamin C Administration On Postoperative Analgesia Completed NCT02639741 Phase 4 Melatonin;Vitamin C
14 Cognitive and Cerebral Blood Flow Effects of Vitamin C Completed NCT01055418 Phase 4
15 Prophylactic Administration of Vitamin C in Wrist Fractures; a Randomized Placebo Controlled Multicentre Dose-Finding Study of the Incidence of Complex Regional Pain Syndrome Completed NCT00296868 Phase 4 ascorbic acid (vitamin C) versus placebo
16 Pharmacokinetics of Two Different High-dose Regimens of Intravenous Vitamin C in Critically Ill Patients Completed NCT02455180 Phase 4 Ascorbic Acid
17 Phase 4 Study of High Dose Vitamin C in Chronic Hepatitis Patients Completed NCT01413360 Phase 4 High dose vitamin C
18 The Role of a Single Oral Dose (2g) of Vitamin C in Reducing Intensity of Pain and Opioids Consumption in Patients Undergoing Laparoscopic Cholecystectomy. A Randomized, Double-blinded, Placebo-controlled Study Completed NCT01322061 Phase 4 Ascorbic Acid
19 The First-day High Dose Vitamin E and Vitamin C in Hypoxic Ischemic Encephalopathy (Following Birth Asphyxia) in Newborns Completed NCT01743742 Phase 4 Vitamin E, Vitamin C
20 Effect of Oral Vitamin C on The Inflammatory Biomarkers in Hemodialysis Completed NCT01356433 Phase 4 oral vitamin C
21 Double-Blind, Randomized Study of High Dose Vitamin C On Outcome in Cardiac Surgery Patients Completed NCT01167569 Phase 4 Ascorbic Acid
22 Can Vitamin C Reduce the Risk of Postoperative Shoulder Stiffness? A Mono-center, Double-blinded, Randomized and Placebo-controlled Study Recruiting NCT04472000 Phase 4 Vitamin C;Placebo
23 Vitamin C for Prevention of Urinary Tract Infections in the Spinal Cord Injured Terminated NCT00869427 Phase 4 vitamin C
24 A Randomized, Double Blind, Placebo-Controlled Study to Investigate the Effects of Vitamin C, Hydrocortisone and Thiamine on the Outcome of Patients With Severe Sepsis and Septic Shock Terminated NCT03335124 Phase 4 Vitamin C;Hydrocortisone;Thiamine;0.9% Sodium Chloride Injection
25 Study of Safty and Efficacy of Adjuvant Vitamin c in Augmenting Iron Chelation Unknown status NCT02083575 Phase 2, Phase 3 Vitamin C, Defriprone, deferisarox;deferiprone , deferesarox
26 Effect on Migraine Frequency of Combined Anti-oxidant Therapy: N-acetylcysteine, Vitamin E and Vitamin C (NEC): The MIGRANT Study Unknown status NCT02629536 Phase 3 N-acetyl cysteine 600 mg, VitE 250 IU, VitC 500 mg tablet
27 Pilot Study on the Use of Hydrocortisone, Vitamin c and Tiamine in Patient With Sepsis and Septic Shock Unknown status NCT04111822 Phase 3 red blood cells transfusion, tranexamic acid (TXA) and fibrinogen concentrate;on crystalloid fluid and Tranexamic acid
28 Vitamin C to Reduce Exogenous Vasopressor Dose in Septic Shock; a Randomized Clinical Trial Unknown status NCT03835286 Phase 3 Vitamin C;Placebos
29 Lessening Organ Dysfunction With VITamin C (LOVIT) Completed NCT03680274 Phase 3 Vitamin C
30 Controlled, Randomized, Double-blind, Multicentre Study on Efficacy and Safety of Echinaforce Junior Tablets in Comparison With Vitamin C for the Prevention of Viral Respiratory Tract Infections in Children (4-12 Years) Completed NCT02971384 Phase 3 Echinaforce
31 Efficacy of High Dose Vitamin C Parenteral Supplement on Amelioration of Fatigue in Company Workers After Work: A Double-Blind, Randomized Controlled Trial Completed NCT00633581 Phase 2, Phase 3
32 Initiation of Vitamin C, Thiamine and Hydrocortisone Therapy for Septic Shock in Adults: A Randomized Clinical Trial Completed NCT03872011 Phase 3 Vitamin C,thiamine,hydrocortisone;Placebo
33 Difference in Mortality and Evolution in Septic Patients Treated With Vitamin C, Tiamine, Cyanocobalamine, Pyridoxine and Hydrocortisone Treated at the ICU of General Hospital Zone 11 IMSS Piedras Negras Coahuila. Completed NCT04197115 Phase 3 Vitamin C;Hydrocortisone;Complex B
34 Evaluating Vitamin C in Septic Shock: A Randomized Double Blind Placebo Controlled Trial Completed NCT03338569 Phase 2, Phase 3 Vitamin C;Placebo
35 Randomized Double Blind Study of Administration of Vitamin C for Prophylaxis of Post-operative Atrial Fibrillation in On-pump Cardiac Surgery Procedures Completed NCT01107730 Phase 3 Vitamin C;L-Carnitine;Placebo
36 Randomized, Double-Blind, Placebo-Controlled Trial of Oral Vitamin C on Correction of Anemia in Patients Receiving Peritoneal Dialysis Completed NCT00920413 Phase 3
37 Efficacy of Vitamin C, Vitamin E and Their Combination for Treatment of Restless Legs Syndrome in Hemodialysis Patients: a Randomized Double-blind, Placebo-controlled Trial Completed NCT01125033 Phase 2, Phase 3 Vitamin C & Vitamin E;Vitamin C;Vitamin E;Vitamin C Placebo & Vitamin E Placebo
38 Vitamin C and Vitamin E Therapy in Type 2 Diabetes and Cardiovascular Risk Completed NCT00362518 Phase 3
39 the Effectiveness of Echinacea, Propolis and Vitamin C in the Prevention of Respiratory Tract Infections and Gastroenteritis in Preschool Age Children: a Prospective Study Completed NCT00231218 Phase 3 dietary supplement--echinacea, propolis, and vitamin c
40 Evaluation of the Impact of Rutin and Vitamin C Combination on Oxidative Stress, Insulin Sensitivity and Lipid Profile in Type 2 Diabetic Patients Completed NCT03437902 Phase 2, Phase 3
41 Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function Completed NCT01723696 Phase 2, Phase 3
42 Clinical Trials Phase III, Double Blind, Crossover to Asses the Safety and Efficacy of Vitamin C and Vitamin E in Combination Versus Placebo for Treating Cognitive and Behavior Disorder in Children With Fragile X Syndrome Completed NCT02942498 Phase 3 Vitamin C 10mg/Kg Vitamin E 10 mg/Kg;Placebo
43 A Multi-center, Randomized, Placebo-controlled, Double-blind, Adaptive Clinical Trial of Vitamin C, Thiamine and Steroids as Combination Therapy in Patients With Sepsis. Completed NCT03509350 Phase 3 Vitamin C;Thiamine;Hydrocortisone;Vitamin C Placebo;Thiamine Placebo;Hydrocortisone Placebo
44 Vitamin C Intravenously With Chemotherapy in Peritoneal Metastatic Colorectal Cancer With High Expresison Level of GLUT3 Recruiting NCT04516681 Phase 3 Ascorbic acid;FOLFOXIRI Protocol
45 Early Administration of Vitamin C in Patients With Sepsis or Septic Shock in Emergency Departments: a Multicentre, Double Blinded, Randomized Controlled Trial: the C-EASIE Trial Recruiting NCT04747795 Phase 3 Vitamin C;Normal saline
46 Role of Vitamin C at 6 Months on Incidence of Complex Regional Pain Syndrome Type I in Upper Limb Surgery Recruiting NCT02390505 Phase 3 Vitamin C;Placebo
47 Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock: a Randomized Clinical Study (VITAMIN TRIAL) Recruiting NCT05192213 Phase 3 Vitamin C
48 A Multicentre Concealed-Allocation Parallel-Group Blinded Randomized Controlled Trial to Ascertain the Effect of High-Dose Intravenous Vitamin C Compared to Placebo on Mortality or Persistent Organ Dysfunction at 28 Days in Septic Intensive Care Unit Patients Recruiting NCT04404387 Phase 3 Administration of vitamin C;Administration of placebo
49 Evaluation of The Effect of Rutin and Vitamin C on the Oxidative Stress in Hemodialysis Patients Recruiting NCT04955145 Phase 3 RUTA C 60
50 Effectiveness of Vitamin C Supplementation in Infants and Children Suffering of Nutritional Rickets Enrolling by invitation NCT05310760 Phase 2, Phase 3 Vit C

Search NIH Clinical Center for Hypoascorbemia

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Ascorbic Acid
Ascorbic Acid Powder
Sodium Ascorbate

Cochrane evidence based reviews: scurvy

Sources

Genetic Tests for Hypoascorbemia

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Anatomical Context for Hypoascorbemia

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Organs/tissues related to Hypoascorbemia:

MalaCards : Skin, Endothelial, Lung, Heart, Liver, Bone Marrow, Colon
Sources

Publications for Hypoascorbemia

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Articles related to Hypoascorbemia:

(show top 50) (show all 25988)
# Title Authors PMID Year
1
Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. 62 57
11984597 2002
2
Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. 62 57
8623000 1996
3
A missense mutation of L-gulono-gamma-lactone oxidase causes the inability of scurvy-prone osteogenic disorder rats to synthesize L-ascorbic acid. 62 57
1400508 1992
4
Homo sapiens ascorbicus, a biochemically corrected robust human mutant. 62 57
491997 1979
5
Immunologic evidence that the gene for L-gulono-gamma-lactone oxidase is not expressed in animals subject to scurvy. 62 57
819930 1976
6
The genetic disease, Hypoascorbemia. A fresh approach to an ancient disease and some of its medical implications. 62 57
6063937 1967
7
SVCT2-mediated ascorbic acid uptake buffers stress responses via DNA hydroxymethylation reprogramming of S100 calcium-binding protein A4 gene. 62 41
36436457 2022
8
Enhancing an Oxidative "Trojan Horse" Action of Vitamin C with Arsenic Trioxide for Effective Suppression of KRAS-Mutant Cancers: A Promising Path at the Bedside. 62 41
36359850 2022
9
New view at C. 57
11984580 2002
10
Cloning and chromosomal mapping of the human nonfunctional gene for L-gulono-gamma-lactone oxidase, the enzyme for L-ascorbic acid biosynthesis missing in man. 57
8175804 1994
11
Guinea pigs possess a highly mutated gene for L-gulono-gamma-lactone oxidase, the key enzyme for L-ascorbic acid biosynthesis missing in this species. 57
1400507 1992
12
Occurrence in humans and guinea pigs of the gene related to their missing enzyme L-gulono-gamma-lactone oxidase. 57
3214183 1988
13
New concepts in the biology and biochemistry of ascorbic acid. 57
3513016 1986
14
Evolution and the biosynthesis of ascorbic acid. 57
4752221 1973
15
Evolution and the need for ascorbic acid. 57
5275366 1970
16
Non-Darwinian evolution. 57
5767777 1969
17
Ascorbic acid does not necessarily interfere with the electrochemical detection of dopamine. 41
36418489 2022
18
Untargeted metabolomics of fermented onion (Allium cepa L) using UHPLC Q-TOF MS/MS reveals anti-obesity metabolites and in vivo efficacy in Caenorhabditis elegans. 62
36323042 2023
19
Antioxidant-rich foods and nutritional value in daily kindergarten menu: A randomized controlled evaluation executed in Slovenia. 62
36444013 2023
20
The roles of Salvia miltiorrhiza-derived carbon dots involving in maintaining quality by delaying senescence of postharvest flowering Chinese cabbage. 62
36283319 2023
21
Mixing chia seeds and sprouts at different developmental stages: A cost-effective way to improve antioxidant vitamin composition. 62
36371839 2023
22
Acidic electrolyzed water treatment suppresses Phomopsis longanae Chi-induced the decreased storability and quality properties of fresh longans through modulating energy metabolism. 62
36265275 2023
23
Independent and joint associations of dietary antioxidant intake with risk of post-stroke depression and all-cause mortality. 62
36372128 2023
24
A hydroalcoholic extract of Senecio nutans SCh. Bip (Asteraceae); its effects on cardiac function and chemical characterization. 62
36152785 2023
25
Antioxidant vitamin supplementation on muscle adaptations to resistance training: A double-blind, randomized controlled trial. 62
36283241 2023
26
Comparison of pesticide residue and specific nutrient levels in peeled and unpeeled apples. 62
36468616 2023
27
Luffa rootstock enhances salt tolerance and improves yield and quality of grafted cucumber plants by reducing sodium transport to the shoot. 62
36309299 2023
28
Silicone glue-based graphite ink incorporated on paper platform as an affordable approach to construct stable electrochemical sensors. 62
35961083 2023
29
Cerium/polyacrylic acid modified porphyrin metal-organic framework as fluorescence and photothermal sensor for ascorbic acid measurement. 62
35985190 2023
30
Efficiency of nanoemulsion of essential oils to control Botrytis cinerea on strawberry surface and prolong fruit shelf life. 62
36260958 2023
31
Visual detection of vitamin C in fruits and vegetables using UiO-66 loaded Ce-MnO2 mimetic oxidase. 62
36170775 2023
32
Vitamin C modified crayfish shells biochar efficiently remove tetracycline from water: A good medicine for water restoration. 62
36265698 2023
33
High-dose vitamin C-induced acute oxalate nephropathy in a renal transplant recipient: A case report and literature review. 62
36473810 2022
34
The impact of vitamin C-containing treatment on the mortality of patients with sepsis: A systematic review and meta-analysis of randomized controlled trials. 62
36434995 2022
35
Vaginal delivery is associated with lower levels of thiol groups, vitamin C and ferric reducing ability in colostrum compared with caesarean section. 62
36457295 2022
36
Protective effects and mechanism of amino acids as chokeberry cyanidin and its glycoside protectant under the condition of vitamin C coexistence. 62
35933750 2022
37
Potential utilization of vitamin C industrial effluents in agriculture: Soil fertility and bacterial community composition. 62
36037898 2022
38
Vitamin C inhibits apoptosis in THP‑1 cells in response to incubation with Mycobacterium tuberculosis. 62
36340604 2022
39
Effects of plant morphology, vitamin C, and other co-present pesticides on the deposition, dissipation, and metabolism of chlorothalonil in pakchoi. 62
35789467 2022
40
Vitamin C and fruit quality consensus in breeding elite European strawberry under multiple interactions of environment. 62
36104582 2022
41
Vitamin C for sepsis: Questions remain. 62
36075562 2022
42
Diet-wide association study of 92 foods and nutrients and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study. 62
35830197 2022
43
Association of Dietary Antioxidant Vitamin Intake and Gastric Cancer Risk According to Smoking Status and Histological Subtypes of Gastric Cancer: A Case-Control Study in Korea. 62
36453620 2022
44
Estimation of degradation kinetics of bioactive compounds in several lingonberry jams as affected by different sweeteners and storage conditions. 62
36263245 2022
45
What did we learn in 35 years of research on nutrition and supplements for age-related macular degeneration: a systematic review. 62
35695158 2022
46
Increased Rates of Supplement-Associated Oxalate Nephropathy During COVID-19 Pandemic. 62
36120391 2022
47
Comparative study of oxidative stress and antioxidative markers in patients infected with Toxoplasma gondii. 62
35977613 2022
48
Effect of high intensity ultrasound on main bioactive compounds, antioxidant capacity and color in orange juice. 62
34632838 2022
49
Biogenic synthesis of reduced graphene oxide from Ziziphus spina-christi (Christ's thorn jujube) extracts for catalytic, antimicrobial, and antioxidant potentialities. 62
35859234 2022
50
Ochronotic arthropathy in the context of spondyloarthritis differential diagnosis: a case-based review. 62
36053307 2022
Sources

Variations for Hypoascorbemia

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Expression for Hypoascorbemia

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Search GEO for disease gene expression data for Hypoascorbemia.
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Pathways for Hypoascorbemia

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Pathways related to Hypoascorbemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cellular hexose transport 66
Show member pathways
 10.29 SLC2A8 SLC2A3 SLC2A14 SLC2A1
Sources

GO Terms for Hypoascorbemia

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Cellular components related to Hypoascorbemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane region GO:0098590 8.62 SLC23A2 SLC23A1

Biological processes related to Hypoascorbemia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 10.04 SLC2A8 SLC2A3 SLC2A14 SLC2A1 SLC23A2 SLC23A1
2 glucose import GO:0046323 9.85 SLC2A3 SLC2A14 SLC2A1
3 glucose import across plasma membrane GO:0098708 9.81 SLC2A3 SLC2A1
4 monosaccharide transmembrane transport GO:0015749 9.8 SLC2A1 SLC2A14 SLC2A3
5 L-ascorbic acid transmembrane transport GO:0015882 9.78 SLC23A2 SLC23A1
6 5-methylcytosine catabolic process GO:0006211 9.76 TET2 TET1
7 glucose transmembrane transport GO:1904659 9.76 SLC2A8 SLC2A3 SLC2A14 SLC2A1
8 fructose transmembrane transport GO:0015755 9.71 SLC2A8 SLC2A3
9 L-ascorbic acid biosynthetic process GO:0019853 9.71 RGN AKR1A1
10 carbohydrate transport GO:0008643 9.56 SLC2A8 SLC2A3 SLC2A14 SLC2A1
11 L-ascorbic acid metabolic process GO:0019852 9.56 SLC2A3 SLC2A1 SLC23A2 SLC23A1
12 cellular macromolecule metabolic process GO:0044260 9.52 TET2 TET1
13 macromolecule modification GO:0043412 9.43 TET2 TET1
14 dehydroascorbic acid transport GO:0070837 9.32 SLC2A8 SLC2A3 SLC2A14 SLC2A1 SLC23A1

Molecular functions related to Hypoascorbemia according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 10.03 PAM DBH ALB
2 L-ascorbic acid binding GO:0031418 9.91 PAM P4HA3 DBH
3 transmembrane transporter activity GO:0022857 9.87 SLC2A8 SLC2A3 SLC2A14 SLC2A1 SLC23A2 SLC23A1
4 glucose transmembrane transporter activity GO:0005355 9.86 SLC2A8 SLC2A3 SLC2A14 SLC2A1
5 hexose transmembrane transporter activity GO:0015149 9.85 SLC2A1 SLC2A14 SLC2A3
6 methylcytosine dioxygenase activity GO:0070579 9.81 TET2 TET1
7 L-ascorbic acid transmembrane transporter activity GO:0015229 9.8 SLC23A1 SLC23A2
8 glucose binding GO:0005536 9.8 SLC2A8 SLC2A3 SLC2A14
9 L-ascorbate:sodium symporter activity GO:0008520 9.76 SLC23A2 SLC23A1
10 D-glucose transmembrane transporter activity GO:0055056 9.76 SLC2A1 SLC2A14 SLC2A3 SLC2A8
11 fructose transmembrane transporter activity GO:0005353 9.72 SLC2A8 SLC2A3
12 dioxygenase activity GO:0051213 9.7 TET2 TET1 P4HA3
13 oxidoreductase activity GO:0016491 9.65 TET2 TET1 PRDX4 PAM P4HA3 MIOX
14 transporter activity GO:0005215 9.54 SLC23A2 SLC23A1
15 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen GO:0016715 9.48 PAM DBH
16 dehydroascorbic acid transmembrane transporter activity GO:0033300 9.32 SLC2A8 SLC2A3 SLC2A14 SLC2A1 SLC23A1
Sources

Sources for Hypoascorbemia

About this section
2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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