MCID: HYP016
MIFTS: 42

Hypochondriasis

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Hypochondriasis

MalaCards integrated aliases for Hypochondriasis:

Name: Hypochondriasis 12 76 55 44 15 73
Hypochondriacal Disorder 12
Hypochondriacal Neurosis 12
Hypochondria 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12883
ICD10 33 F45.2 F45.21
ICD9CM 35 300.7
MeSH 44 D006998
NCIt 50 C9493
UMLS 73 C0020604

Summaries for Hypochondriasis

Disease Ontology : 12 A somatoform disorder that involves an excessive preoccupation or worry about having a serious illness.

MalaCards based summary : Hypochondriasis, also known as hypochondriacal disorder, is related to anxiety and depression, and has symptoms including mental and behavioral signs and symptoms An important gene associated with Hypochondriasis is NTF4 (Neurotrophin 4), and among its related pathways/superpathways are Ras signaling pathway and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Dopamine and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include brain and testes, and related phenotype is homeostasis/metabolism.

Wikipedia : 76 Hypochondriasis or hypochondria is a condition in which a person is excessively and unduly worried about... more...

Related Diseases for Hypochondriasis

Graphical network of the top 20 diseases related to Hypochondriasis:



Diseases related to Hypochondriasis

Symptoms & Phenotypes for Hypochondriasis

UMLS symptoms related to Hypochondriasis:


mental and behavioral signs and symptoms

MGI Mouse Phenotypes related to Hypochondriasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.1 F2 GATA3 NTF3 NTF4 PHEX WFDC1

Drugs & Therapeutics for Hypochondriasis

Drugs for Hypochondriasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 2 51-61-6, 62-31-7 681
2
Norepinephrine Approved Phase 4 51-41-2 439260
3 Analgesics Phase 4
4 Antidepressive Agents Phase 4,Phase 1,Phase 2,Not Applicable
5 Dopamine Agents Phase 4,Phase 2
6 Duloxetine Hydrochloride Phase 4,Not Applicable
7 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2
8 Neurotransmitter Uptake Inhibitors Phase 4,Phase 1,Phase 2
9 Peripheral Nervous System Agents Phase 4
10 Psychotropic Drugs Phase 4,Phase 1,Phase 2,Not Applicable
11 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
12
Serotonin Investigational, Nutraceutical Phase 4,Phase 1,Phase 2 50-67-9 5202
13
Lamotrigine Approved, Investigational Phase 3 84057-84-1 3878
14 Anticonvulsants Phase 3
15 calcium channel blockers Phase 3
16 Calcium, Dietary Phase 3
17 Diuretics, Potassium Sparing Phase 3
18 Excitatory Amino Acid Antagonists Phase 3
19 Excitatory Amino Acids Phase 3
20 Sodium Channel Blockers Phase 3
21
Fluoxetine Approved, Vet_approved Phase 1, Phase 2,Not Applicable 54910-89-3 3386
22
Paroxetine Approved, Investigational Phase 2,Not Applicable 61869-08-7 43815
23
Bupropion Approved Phase 2,Not Applicable 34841-39-9, 34911-55-2 444
24
Substance P Investigational Phase 2 33507-63-0 44359816
25 Antidepressive Agents, Second-Generation Phase 1, Phase 2,Phase 2
26 Cytochrome P-450 CYP2D6 Inhibitors Phase 1, Phase 2,Phase 2
27 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2,Phase 2
28 Serotonin Agents Phase 1, Phase 2,Phase 2
29 Serotonin Uptake Inhibitors Phase 1, Phase 2,Phase 2
30 Dopamine Uptake Inhibitors Phase 2
31 neurokinin A Phase 2
32 Pharmaceutical Solutions Not Applicable
33 Anti-Anxiety Agents Not Applicable

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Multi-Port Versus Single-port Cholecystectomy Completed NCT01104727 Phase 4
2 A Study Comparing Duloxetine and Placebo in Assessing Energy and Vitality in Major Depressive Disorder (MDD) Patients Completed NCT00536471 Phase 4 Duloxetine hydrochloride;Placebo
3 Comparing Cognitive Therapy and Exposure Therapy in Individuals With Hypochondriasis Completed NCT01119469 Phase 3
4 Integrated Treatment Program for Hypochondriasis in Primary Care Settings Completed NCT00368212 Phase 3
5 Lamotrigine Phase III Study in Bipolar I Disorder Completed NCT01602510 Phase 3 Lamotrigine;Placebo
6 Treatment of Hypochondriasis With CBT and/or SSRI Completed NCT00339079 Phase 1, Phase 2 Fluoxetine;Placebo
7 KATHY:Cognitive-behavioural Therapy for Hypochondriasis Completed NCT00208247 Phase 2
8 Internet-delivered Cognitive Behavioral Therapy (CBT) for Health Anxiety Completed NCT00828152 Phase 2
9 MDD POC Study GSK372475 Subjects Depressive Disease Completed NCT00420641 Phase 2 GSK372475;Paroxetine
10 Study Of 323U66 SR In Major Depressive Disorder Completed NCT00135512 Phase 2 bupropion hydrochloride
11 An Efficacy, Safety and Tolerability Study of JNJ-42165279 in Participants With Major Depressive Disorder With Anxious Distress Recruiting NCT02498392 Phase 2 JNJ-42165279
12 A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Fixed Dose Study Evaluating the Efficacy and Safety of Orvepitant in Subjects With Major Depressive Disorder Terminated NCT00880399 Phase 2 orvepitant
13 Safety and Efficacy of MK-6096 as Adjunctive Therapy in Participants With Major Depressive Disorder And Partial Response to Antidepressant Monotherapy (MK-6096-022) Terminated NCT01554176 Phase 2 Filorexant;Placebo
14 A Study to Investigate the Antidepressant Mechanism-of-action of JNJ-42847922 in Participants With Major Depressive Disorder Recruiting NCT03374475 Phase 1 JNJ-42847922 20mg;JNJ-42847922 40mg;Placebo
15 Promoting Informed Decision Making Through Advance Care Planning Unknown status NCT02211287 Not Applicable
16 Prospective Cohort Study of Accelerated Resolution Therapy (ART) for Treatment of Military Psychological Trauma Unknown status NCT02030522 Not Applicable
17 Internet Treatment for Health Anxiety Completed NCT01673035 Not Applicable
18 Metacognitive Therapy for Health Anxiety Completed NCT02404116 Not Applicable
19 Acceptance and Commitment Group Therapy (ACT) for Patients With Health Anxiety Completed NCT01158430 Not Applicable
20 Educational Physiotherapy in Haemophilia Completed NCT02825706 Not Applicable
21 The Unified Protocol for the Treatment of Emotional Disorders in Spanish Public Mental Health System Recruiting NCT03064477 Not Applicable
22 Follow up of Patients Treated With Cognitive Behavioural Therapy for Hypochondria From 1997 to 2007 Active, not recruiting NCT00959452 Not Applicable
23 Internet-delivered Acceptance and Commitment Therapy for Patients With Health Anxiety Active, not recruiting NCT02735434 Not Applicable
24 Outcome of Cognitive Behavioral Therapy for Patients With Severe Health Anxiety Treated in Group Only. A RCT. Active, not recruiting NCT02131883 Not Applicable
25 An Examination of the Effects of Health-related Internet Use in Individuals With Pathological Health Anxiety Not yet recruiting NCT03024593 Not Applicable
26 Effect of Osteopathic Manipulations on Portal Venous Flow Not yet recruiting NCT03516344 Not Applicable
27 Supplemental Transcranial Magnetic Stimulation (TMS) vs. Standard Medication Monotherapy for Treating Major Depression: An Exploratory Field Study Withdrawn NCT01944657 Not Applicable Standard Medication Monotherapy

Search NIH Clinical Center for Hypochondriasis

Cochrane evidence based reviews: hypochondriasis

Genetic Tests for Hypochondriasis

Anatomical Context for Hypochondriasis

MalaCards organs/tissues related to Hypochondriasis:

41
Brain, Testes

Publications for Hypochondriasis

Articles related to Hypochondriasis:

(show top 50) (show all 354)
# Title Authors Year
1
Treatment of Hypochondriasis in Two Schizophrenia Patients Using Clozapine. ( 28642831 )
2017
2
Cognitive therapy and exposure therapy for hypochondriasis (health anxiety): A 3-year naturalistic follow-up. ( 28956951 )
2017
3
A Randomized Controlled Trial of Medication and Cognitive-Behavioral Therapy for Hypochondriasis. ( 28659038 )
2017
4
Validity of Current Treatment Protocols to Overcome Hypochondriasis. ( 28274027 )
2017
5
New Insights on the Treatment of Hypochondriasis. ( 28760014 )
2017
6
DSM-5 illness anxiety disorder and somatic symptom disorder: Comorbidity, correlates, and overlap with DSM-IV hypochondriasis. ( 28867421 )
2017
7
Emotion dysregulation in hypochondriasis and depression. ( 28444850 )
2017
8
Avoidance in hypochondriasis. ( 27663110 )
2016
9
The Relationship of Hypochondriasis to Anxiety, Depressive, and Somatoform Disorders. ( 26785798 )
2016
10
Cross-national differences in hypochondriasis symptoms between Korean and American outpatients with major depressive disorder. ( 27541348 )
2016
11
Personality Disorders in Hypochondriasis: A Comparison to Panic Disorder and Healthy Controls. ( 27749185 )
2016
12
Hypochondriasis Differs From Panic Disorder and Social Phobia: Specific Processes Identified Within Patient Groups. ( 27805984 )
2016
13
Patient Characteristics and Patient Behavior as Predictors of Outcome in Cognitive Therapy and Exposure Therapy for Hypochondriasis. ( 27532367 )
2016
14
Changes in Free Symptom Attributions in Hypochondriasis after Cognitive Therapy and Exposure Therapy. ( 27126076 )
2016
15
Co-morbid obsessive compulsive and hypochondriac disorders complicated by tardive dyskinesia in a Nigerian man. ( 26755234 )
2016
16
Fears, Coping Styles, and Health Behaviors: A Comparison of Patients With Hypochondriasis, Panic Disorder, and Depression. ( 27441462 )
2016
17
Hypochondriasis Circumscripta: A Neglected Concept with Important Implications in Psychodermatology. ( 27283953 )
2016
18
Mindfulness-Based Cognitive Therapy (MBCT) for Health Anxiety (Hypochondriasis): Rationale, Implementation and Case Illustration. ( 25798209 )
2015
19
Therapist competence and therapeutic alliance are important in the treatment of health anxiety (hypochondriasis). ( 25977073 )
2015
20
Hypochondriasis as an early manifestation of dementia with Lewy bodies: an autopsied case report. ( 25919332 )
2015
21
Health anxiety and hypochondriasis in the light of DSM-5. ( 25846805 )
2015
22
Response and Remission After Cognitive and Exposure Therapy for Hypochondriasis. ( 26513512 )
2015
23
Health Behavior in Hypochondriasis. ( 26039700 )
2015
24
Exposure therapy changes dysfunctional evaluations of somatic symptoms in patients with hypochondriasis (health anxiety). A randomized controlled trial. ( 26093823 )
2015
25
The symptom in the body. Monosymptomatic psychosis and hypochondriasis: A report of two cases. ( 25999159 )
2015
26
Hypochondriasis: treatment options for a diagnostic quagmire. ( 26019287 )
2015
27
Effectiveness of cognitive-behavioral group therapy for patients with hypochondriasis (health anxiety). ( 25589453 )
2015
28
Changes in negative implicit evaluations in patients of hypochondriasis after treatment with cognitive therapy or exposure therapy. ( 26204567 )
2015
29
Cognitive-behavioral therapy for hypochondriasis/health anxiety: a meta-analysis of treatment outcome and moderators. ( 24954212 )
2014
30
Hypochondriasis: considerations for ICD-11. ( 25388609 )
2014
31
Childhood maltreatment is associated with depression but not with hypochondriasis in later life. ( 25077850 )
2014
32
The Multidimensional Inventory of Hypochondriacal Traits: Factor Structure, Specificity, Reliability, and Validity in Patients With Hypochondriasis. ( 25092716 )
2014
33
Assessment of Implicit Health Attitudes: A Multitrait-Multimethod Approach and a Comparison Between Patients With Hypochondriasis and Patients With Anxiety Disorders. ( 24815573 )
2014
34
Implicit affective evaluation bias in hypochondriasis: findings from the Affect Misattribution Procedure. ( 25124504 )
2014
35
The departure of hypochondriasis is no loss. ( 25048652 )
2014
36
Personality predicts time to remission and clinical status in hypochondriasis during a 6-year follow-up. ( 24727716 )
2014
37
Cenesthopathy in adolescence: an appraisal of diagnostic overlaps along the anxiety-hypochondriasis-psychosis spectrum. ( 24679416 )
2014
38
The role of disgust in patients with hypochondriasis. ( 24325445 )
2014
39
Will hypochondriasis be "alive and well" in the ICD-11? ( 25381214 )
2014
40
Cognitive Therapy Versus Exposure Therapy for Hypochondriasis (Health Anxiety): A Randomized Controlled Trial. ( 25495359 )
2014
41
DSM-5 bids farewell to hypochondriasis and welcomes somatic symptom disorder and illness anxiety disorder. ( 24574368 )
2014
42
Treatment of Mental Hypochondriasis: A Case Report. ( 23934504 )
2013
43
Hypochondriasis: attentional, sensory, and cognitive factors. ( 23295009 )
2013
44
Assessing Bodily Preoccupations is sufficient: clinically effective screening for hypochondriasis. ( 24290041 )
2013
45
Hypochondriasis and health anxiety: conceptual challenges. ( 23284146 )
2013
46
Should we deplore the disappearance of hypochondriasis from DSM-5? ( 24293052 )
2013
47
Specificity and modifiability of cognitive biases in hypochondriasis. ( 22563641 )
2013
48
Attribution of Somatic Symptoms in Hypochondriasis. ( 24123559 )
2013
49
Previous Experiences With Illness and Traumatic Experiences: A Specific Risk Factor For Hypochondriasis? ( 24360529 )
2013
50
Hypochondriasis and obsessive-compulsive disorder in schizophrenic patients treated with clozapine vs other atypical antipsychotics. ( 24176043 )
2013

Variations for Hypochondriasis

Expression for Hypochondriasis

Search GEO for disease gene expression data for Hypochondriasis.

Pathways for Hypochondriasis

Pathways related to Hypochondriasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.97 NTF3 NTF4 RASAL1
2 11.15 NTF3 NTF4
3
Show member pathways
10.78 NTF3 NTF4
4
Show member pathways
10.41 NTF3 NTF4

GO Terms for Hypochondriasis

Cellular components related to Hypochondriasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 synaptic vesicle GO:0008021 8.62 NTF3 NTF4

Biological processes related to Hypochondriasis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.65 F2 NTF3 NTF4
2 cell-cell signaling GO:0007267 9.58 NTF3 NTF4 PHEX
3 negative regulation of inflammatory response GO:0050728 9.49 GATA3 WFDC1
4 memory GO:0007613 9.46 NTF3 NTF4
5 neuron projection morphogenesis GO:0048812 9.43 NTF3 NTF4
6 modulation of chemical synaptic transmission GO:0050804 9.37 NTF3 NTF4
7 regulation of neuron differentiation GO:0045664 9.32 NTF3 NTF4
8 peripheral nervous system development GO:0007422 9.26 NTF3 NTF4
9 nerve development GO:0021675 9.16 NTF3 NTF4
10 locomotion GO:0040011 8.96 NTF3 NTF4
11 nerve growth factor signaling pathway GO:0038180 8.62 NTF3 NTF4

Molecular functions related to Hypochondriasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 F2 NTF3 NTF4
2 neurotrophin p75 receptor binding GO:0005166 8.62 NTF3 NTF4

Sources for Hypochondriasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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