MCID: HYP016
MIFTS: 47

Hypochondriasis

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Hypochondriasis

MalaCards integrated aliases for Hypochondriasis:

Name: Hypochondriasis 12 74 54 44 15 71
Hypochondriacal Disorder 12 32
Hypochondriacal Neurosis 12
Hypochondria 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12883
ICD9CM 34 300.7
MeSH 44 D006998
NCIt 50 C9493
SNOMED-CT 67 18193002
ICD10 32 F45.2 F45.21
UMLS 71 C0020604

Summaries for Hypochondriasis

Disease Ontology : 12 A somatoform disorder that involves an excessive preoccupation or worry about having a serious illness.

MalaCards based summary : Hypochondriasis, also known as hypochondriacal disorder, is related to somatization disorder and obsessive-compulsive personality disorder, and has symptoms including mental and behavioral signs and symptoms An important gene associated with Hypochondriasis is NTF4 (Neurotrophin 4), and among its related pathways/superpathways are CREB Pathway and G-Beta Gamma Signaling. The drugs Fluoxetine and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and colon, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 74 Hypochondriasis or hypochondria is a condition in which a person is excessively and unduly worried about... more...

Related Diseases for Hypochondriasis

Diseases related to Hypochondriasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 somatization disorder 30.7 SLC6A4 POMC OXT HTR1A
2 obsessive-compulsive personality disorder 30.2 SLC6A4 HTR2A
3 alexithymia 30.1 SLC6A4 OXT HTR1A
4 agoraphobia 29.9 SLC6A4 HTR2A HTR1A CRHR1 BDNF
5 antisocial personality disorder 29.9 SLC6A4 OXT HTR2A
6 paranoid schizophrenia 29.9 SLC6A4 HTR2A HTR1A BDNF
7 personality disorder 29.8 SLC6A4 HTR2C HTR2A HTR1A CRHR1 BDNF
8 body dysmorphic disorder 29.8 SLC6A4 SLC1A1 OXT HTR2A
9 delusional disorder 29.8 HTR2C HTR2A HTR1A
10 generalized anxiety disorder 29.8 SLC6A4 HTR2A HTR1A CRHR1 BDNF
11 panic disorder 29.8 SLC6A4 POMC HTR2C HTR2A HTR1A CRHR1
12 melancholia 29.7 SLC6A4 POMC HTR2A HTR1A BDNF
13 fibromyalgia 29.6 SLC6A4 POMC HTR2A BDNF
14 neurotic disorder 29.6 SLC6A4 POMC OXT HTR2A HTR1A BDNF
15 obsessive-compulsive disorder 29.4 SLC6A4 SLC1A1 POMC OXT HTR2C HTR2A
16 depression 29.3 SLC6A4 HTR2C HTR2A HTR1A CRHR1 BDNF
17 chronic fatigue syndrome 29.3 SLC6A4 POMC HTR2A HTR1A CRHR1 BDNF
18 social phobia 29.3 SLC6A4 OXT HTR2A HTR1A CRHR1 BDNF
19 borderline personality disorder 29.2 SLC6A4 HTR2C HTR2A HTR1A CRHR1 BDNF
20 alcohol use disorder 29.2 SLC6A4 HTR2C HTR2A HTR1A CRHR1 BDNF
21 dysthymic disorder 29.2 SLC6A4 POMC HTR2C HTR2A HTR1A BDNF
22 phobia, specific 29.1 SLC6A4 OXT HTR2A HTR1A CRHR1 BDNF
23 anxiety 29.1 SLC6A4 SLC1A1 POMC OXT HTR2C HTR2A
24 mood disorder 29.1 SLC6A4 POMC HTR2C HTR2A HTR1A CRHR1
25 atypical depressive disorder 29.1 SLC6A4 POMC HTR2A HTR1A CRHR1 BDNF
26 substance abuse 29.0 SLC6A4 POMC HTR2A HTR1A CRHR1 BDNF
27 mental depression 29.0 SLC6A4 POMC OXT HTR2C HTR2A HTR1A
28 alcohol dependence 28.8 SLC6A4 POMC HTR2C HTR2A HTR1A CRHR1
29 endogenous depression 28.8 SLC6A4 POMC OXT HTR2A HTR1A CRHR1
30 major depressive disorder 28.7 SLC6A4 POMC OXT HTR2C HTR2A HTR1A
31 phobic disorder 28.7 SLC6A4 POMC OXT HTR2A HTR1A CRHR1
32 schizophrenia 27.8 SLC6A4 SLC1A1 POMC OXT NTF3 HTR2C
33 kleptomania 10.3 SLC6A4 HTR1A
34 myofascial pain syndrome 10.2 POMC BDNF
35 alcoholic psychosis 10.2 SLC6A4 HTR2A
36 somatoform disorder 10.2
37 anterograde amnesia 10.2 HTR1A BDNF
38 conversion disorder 10.2 HTR2A BDNF
39 animal phobia 10.2 SLC6A4 OXT
40 oculogyric crisis 10.2 HTR2A HTR1A
41 avoidant personality disorder 10.2
42 diamond-blackfan anemia 5 10.2 SLC6A4 HTR1A
43 sexual sadism 10.2 OXT BDNF
44 secondary progressive multiple sclerosis 10.2 NTF4 NTF3 BDNF
45 motion sickness 10.1 POMC HTR1A
46 pathological gambling 10.1 SLC6A4 HTR2A HTR1A
47 cannabis abuse 10.1 HTR1A BDNF
48 ocular dominance 10.1 NTF3 HTR2C BDNF
49 tic disorder 10.1 SLC6A4 SLC1A1 HTR2A
50 trigeminal neuralgia 10.1 SLC6A4 BDNF

Comorbidity relations with Hypochondriasis via Phenotypic Disease Network (PDN):


Acute Cystitis Anxiety
Dependent Personality Disorder Dysthymic Disorder
Generalized Anxiety Disorder Hypertension, Essential
Irritable Bowel Syndrome Major Depressive Disorder
Somatization Disorder

Graphical network of the top 20 diseases related to Hypochondriasis:



Diseases related to Hypochondriasis

Symptoms & Phenotypes for Hypochondriasis

UMLS symptoms related to Hypochondriasis:


mental and behavioral signs and symptoms

MGI Mouse Phenotypes related to Hypochondriasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.93 BDNF CRHR1 ELP6 HTR1A HTR2A HTR2C
2 homeostasis/metabolism MP:0005376 9.7 BDNF CRHR1 HTR1A HTR2C NTF3 NTF4
3 nervous system MP:0003631 9.32 BDNF CRHR1 HTR1A HTR2C NTF3 NTF4

Drugs & Therapeutics for Hypochondriasis

Drugs for Hypochondriasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluoxetine Approved, Vet_approved Phase 1, Phase 2 54910-89-3 3386
2 Neurotransmitter Agents Phase 1, Phase 2
3 Antidepressive Agents Phase 1, Phase 2
4 Psychotropic Drugs Phase 1, Phase 2
5 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2
6 Serotonin Uptake Inhibitors Phase 1, Phase 2
7
Serotonin Investigational, Nutraceutical Phase 1, Phase 2 50-67-9 5202

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Treating Refractory Symptoms in Primary Care (Hypochondriasis: Diagnosis, Description and Medical Care) Completed NCT00368212 Phase 3
2 Dysfunctional Illness-related Cognitions in Individuals With Hypochondriasis and Change Thereof Completed NCT01119469 Phase 3
3 Treatment of Hypochondriasis With CBT and/or SSRI Completed NCT00339079 Phase 1, Phase 2 Fluoxetine;Placebo
4 Cognitive-behavioural Therapy Versus Short-term Psychodynamic Psychotherapy: a Randomised Clinical Trial Completed NCT00208247 Phase 2
5 Internet-delivered Cognitive Behavioural Therapy for Health Anxiety - a Randomized Controlled Trial Completed NCT00828152 Phase 2
6 Internet-delivered Acceptance and Commitment Therapy for Patients With Health Anxiety: a Randomized Controlled Trial Unknown status NCT02735434
7 An Examination of the Effects of Health-related Internet Use in Individuals With Pathological Health Anxiety in a Randomized Controlled Trial Unknown status NCT03024593
8 Treatment of Patients With Health Anxiety. A Randomized Controlled Trial of Acceptance and Commitment Therapy (ACT) Group Treatment Compared to a Waiting List Completed NCT01158430
9 Metacognitive Therapy for Health Anxiety: A Randomised Control Trial Completed NCT02404116
10 Cognitive Behavior Therapy vs. Behavioral Stress Management for Severe Health Anxiety: a Randomized Controlled Trial of Two Internet-based Treatments Completed NCT01673035
11 Outcome of Cognitive Behavior Therapy for Patients With Severe Health Anxiety Treated in Group Only. A Randomised Controlled Trial. The CHAG-Trial. Categorical and Dimensional Characteristics of Personality Pathology and Predictors of Outcome Completed NCT02131883
12 Follow up of Patients Treated With Cognitive Behavioural Therapy at Clinic for Hypochondriacs, Haraldsplass Deaconal Hospital, From 1997 to 2007 Active, not recruiting NCT00959452

Search NIH Clinical Center for Hypochondriasis

Cochrane evidence based reviews: hypochondriasis

Genetic Tests for Hypochondriasis

Anatomical Context for Hypochondriasis

MalaCards organs/tissues related to Hypochondriasis:

40
Brain, Breast, Colon, Spinal Cord, Thyroid, Pituitary, Eye

Publications for Hypochondriasis

Articles related to Hypochondriasis:

(show top 50) (show all 1330)
# Title Authors PMID Year
1
[Serotonin type 2a (5-HTR2A) receptor gene polymorphism and personality traits in patients with endogenous psychoses]. 54 61
11421130 2001
2
'The voice of the stomach': the mind, hypochondriasis and theories of dyspepsia in the nineteenth century. 61
33176503 2021
3
Diagnostic utility of the Minnesota multiphasic personality inventory-2 in patients diagnosed with psychogenic non-epileptic seizures in the Czech Republic. 61
33385953 2021
4
Personality changes in patients with refractory epilepsy after surgical treatment: A systematic review. 61
33453594 2021
5
Why the symptoms and objective signs of dry eye disease may not correlate. 61
33243674 2021
6
Psychological defence mechanisms during the COVID-19 pandemic: A case series. 61
33191967 2021
7
Factors for Social Stressors Among Type 2 Diabetics Versus Non-Diabetics Using the Hamilton Depression Rating Scale. 61
33409095 2020
8
Covidophobia: From Cytokine Storm to Mass Hysteria, a New Subtype of Hypochondriasis? 61
33496255 2020
9
Mental health outcomes among patients from Fangcang shelter hospitals exposed to COVID-19: An observational cross-sectional study. 61
33318879 2020
10
An analysis on the panic during COVID-19 pandemic through an online form. 61
32697692 2020
11
Krankheitsängste und Hypochondrische Störung. 61
33187009 2020
12
Personality proļ¬les in paradoxical insomnia: a case-control study. 61
33564371 2020
13
A comparison of patients with somatic symptom disorder attending psychiatric services and those unwilling to attend psychiatric services. 61
32474346 2020
14
Psychological profiles of irritable bowel syndrome patients with different phenotypes. 61
33131233 2020
15
Fear and Psychopathology During the COVID-19 Crisis: Neuroticism, Hypochondriasis, Reassurance-Seeking, and Coronaphobia as Fear Factors. 61
32762291 2020
16
Impact of Endoscopists' Personality Traits on Adenoma and Polyp Detection Rates in Colonoscopy: A KASID Multicenter Study. 61
32157497 2020
17
Psychological characteristics and associations between living kidney transplantation recipients and biologically related or unrelated donors. 61
32819286 2020
18
Relationships Between Somatic Symptoms and Panic-Agoraphobic Spectrum Among Frequent Attenders of the General Practice in Italy. 61
32205774 2020
19
Changes in the Type of Sports Activity Due to COVID-19: Hypochondriasis and the Intention of Continuous Participation in Sports. 61
32640684 2020
20
Validation of the Arabic version of the Childhood Illness Attitudes Scales. 61
32621501 2020
21
Psychiatric characteristics of older persons with medically unexplained symptoms: A comparison with older patients suffering from medically explained symptoms. 61
32431253 2020
22
Is cyberchondria a new transdiagnostic digital compulsive syndrome? A systematic review of the evidence. 61
32146315 2020
23
Why health anxiety needs to be recognised in hospital practice. 61
32414727 2020
24
Dysfunctional beliefs as mediators between illness-related intrusive thoughts and health anxiety symptoms. 61
31597585 2020
25
The Influence of Socio-Demographic Factors, Lifestyle and Psychiatric Indicators on Adherence to Treatment of Patients with Rheumatoid Arthritis: A Cross-Sectional Study. 61
32295226 2020
26
Long-term effect of cognitive-behavioural therapy in patients with Hypochondriacal Disorder. 61
32345417 2020
27
Mental disorders and total mortality after 20 years in an adult general population sample. 61
32115002 2020
28
Sustained benefit of cognitive behaviour therapy for health anxiety in medical patients (CHAMP) over 8 years: a randomised-controlled trial. 61
32174296 2020
29
DSM-5 Personality Disorders and Traits in Patients With Severe Health Anxiety. 61
31821216 2020
30
On the Nature of Fear and Anxiety Triggered by COVID-19. 61
33240172 2020
31
A Comparative Study of Health Anxiety in Neurology and Psychiatry Settings. 61
32140015 2020
32
Health anxiety among medical students: A comparison between preclinical and clinical years of training. 61
33575392 2020
33
Illness-related intrusive thoughts and illness anxiety disorder. 61
31957211 2020
34
Psychological Characteristics in Patients with Chronic Complex Regional Pain Syndrome: Comparisons with Patients with Major Depressive Disorder and Other Types of Chronic Pain. 61
32104060 2020
35
Gray Matter Volume and Functional Connectivity in Hypochondriasis: A Magnetic Resonance Imaging and Support Vector Machine Analysis. 61
33343319 2020
36
Medical Maximizing-Minimizing Predicts Patient Preferences for High- and Low-Benefit Care. 61
31975657 2020
37
Impact of nickel oral hyposensitization on quality of life in systemic nickel allergy syndrome. 61
32567420 2020
38
Noddle Pox: Syphilis and the Conception of Nosomania/Nosophobia (c. 1665-c. 1965). 61
32822549 2020
39
Cognitive behavior therapy for health anxiety: systematic review and meta-analysis of clinical efficacy and health economic outcomes. 61
31859542 2019
40
The assessment of cognitive-behavioral therapy skills in patients diagnosed with health anxiety: Development and pilot study on an observer-based rating scale. 61
31218759 2019
41
Somatic symptom disorder: a diagnostic dilemma. 61
31772129 2019
42
Cushing's disease: a prospective case-control study of health-related quality of life and cognitive status before and after surgery. 61
31731265 2019
43
Clinical and psychological characteristics of patients with globus. 61
30772327 2019
44
Relationship between VEGF-related gene polymorphisms and brain morphology in treatment-naïve patients with first-episode major depressive disorder. 61
30406404 2019
45
The Spanish validation of the Short Health Anxiety Inventory: Psychometric properties and clinical utility. 61
31516503 2019
46
Hypochondriasis in the elderly and Lewy body disease. 61
30761685 2019
47
Revalidation of Adjustment Disorder-New Module-4 screening of adjustment disorder in a non-clinical sample: Psychometric reevaluation and correlates with other ICD-11 mental disorders. 61
30983131 2019
48
Data on gray matter alterations in anxious depression. 61
31453297 2019
49
Smaller Pituitary Volumes in Patients with Delusional Disorder. 61
31762560 2019
50
A loneliness model of hypochondriasis among older adults: The mediating role of intolerance of uncertainty and anxious symptoms. 61
30974401 2019

Variations for Hypochondriasis

Expression for Hypochondriasis

Search GEO for disease gene expression data for Hypochondriasis.

Pathways for Hypochondriasis

Pathways related to Hypochondriasis according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.06 NTF4 NTF3 HTR2C HTR2A HTR1A BDNF
2
Show member pathways
12.78 POMC HTR2C HTR2A CRHR1 BDNF
3 11.96 POMC OXT HTR1A BDNF
4
Show member pathways
11.69 HTR2C HTR2A HTR1A
5 11.67 SLC6A4 HTR2A HTR1A BDNF
6
Show member pathways
11.55 NTF4 NTF3 BDNF
7 11.51 NTF4 NTF3 BDNF
8
Show member pathways
11.36 NTF4 NTF3 BDNF
9 11.32 SLC6A4 HTR2C HTR2A HTR1A
10
Show member pathways
11.22 NTF4 NTF3 BDNF
11
Show member pathways
10.91 SLC6A4 HTR1A
12 10.84 HTR2C HTR2A
13 10.83 POMC HTR2C
14 10.37 SLC6A4 HTR2C HTR2A HTR1A
15 10.25 POMC CRHR1

GO Terms for Hypochondriasis

Cellular components related to Hypochondriasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.85 SLC6A4 SLC1A1 HTR2C HTR2A HTR1A CRHR1
2 synapse GO:0045202 9.8 SLC6A4 SLC1A1 MFF HTR2C HTR2A HTR1A
3 axon GO:0030424 9.65 SLC1A1 NTF4 NTF3 HTR2A BDNF
4 presynapse GO:0098793 9.58 SLC6A4 SLC1A1 HTR2A
5 synaptic vesicle GO:0008021 9.26 NTF4 NTF3 MFF BDNF
6 dendrite GO:0030425 9.17 SLC1A1 NTF4 NTF3 HTR2C HTR2A HTR1A
7 G protein-coupled serotonin receptor complex GO:0098666 9.16 HTR2C HTR2A

Biological processes related to Hypochondriasis according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 10.09 POMC OXT HTR2C HTR2A HTR1A CRHR1
2 signal transduction GO:0007165 9.97 POMC OXT NTF4 NTF3 HTR2C HTR2A
3 chemical synaptic transmission GO:0007268 9.89 SLC1A1 HTR2C HTR2A HTR1A
4 negative regulation of neuron apoptotic process GO:0043524 9.82 NTF4 NTF3 BDNF
5 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.81 NTF4 NTF3 BDNF
6 response to estradiol GO:0032355 9.8 WFDC1 SLC6A4 OXT
7 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.78 NTF4 NTF3 BDNF
8 modulation of chemical synaptic transmission GO:0050804 9.77 NTF4 NTF3 BDNF
9 response to drug GO:0042493 9.77 WFDC1 SLC6A4 SLC1A1 HTR2C HTR2A
10 neuron projection morphogenesis GO:0048812 9.76 NTF4 NTF3 BDNF
11 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.73 HTR2C HTR2A HTR1A
12 activation of phospholipase C activity GO:0007202 9.69 NTF4 HTR2A BDNF
13 regulation of neuron differentiation GO:0045664 9.67 NTF4 NTF3 BDNF
14 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.65 HTR2C HTR2A HTR1A
15 neurotrophin TRK receptor signaling pathway GO:0048011 9.64 NTF4 BDNF
16 vasoconstriction GO:0042310 9.63 SLC6A4 HTR1A
17 sleep GO:0030431 9.61 OXT HTR2A
18 peripheral nervous system development GO:0007422 9.61 NTF4 NTF3 BDNF
19 regulation of appetite GO:0032098 9.58 POMC HTR2C
20 behavioral fear response GO:0001662 9.58 SLC1A1 HTR2C HTR1A
21 serotonin receptor signaling pathway GO:0007210 9.57 HTR2A HTR1A
22 sperm ejaculation GO:0042713 9.55 SLC6A4 OXT
23 positive regulation of phosphatidylinositol biosynthetic process GO:0010513 9.54 HTR2C HTR2A
24 phospholipase C-activating serotonin receptor signaling pathway GO:0007208 9.52 HTR2C HTR2A
25 regulation of corticosterone secretion GO:2000852 9.46 POMC CRHR1
26 nerve development GO:0021675 9.43 NTF4 NTF3 BDNF
27 behavior GO:0007610 9.33 HTR2C HTR2A HTR1A
28 nerve growth factor signaling pathway GO:0038180 9.13 NTF4 NTF3 BDNF
29 memory GO:0007613 9.1 SLC6A4 OXT NTF4 NTF3 HTR2A BDNF

Molecular functions related to Hypochondriasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.71 POMC NTF4 NTF3 BDNF
2 growth factor activity GO:0008083 9.61 NTF4 NTF3 BDNF
3 neurotransmitter receptor activity GO:0030594 9.54 HTR2C HTR2A HTR1A
4 G protein-coupled serotonin receptor activity GO:0004993 9.43 HTR2C HTR2A HTR1A
5 Gq/11-coupled serotonin receptor activity GO:0001587 9.32 HTR2C HTR2A
6 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding GO:0071886 9.16 HTR2C HTR2A
7 nerve growth factor receptor binding GO:0005163 9.13 NTF4 NTF3 BDNF
8 serotonin binding GO:0051378 8.92 SLC6A4 HTR2C HTR2A HTR1A

Sources for Hypochondriasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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