MCID: HYP016
MIFTS: 45

Hypochondriasis

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Hypochondriasis

MalaCards integrated aliases for Hypochondriasis:

Name: Hypochondriasis 12 74 54 43 15 71
Hypochondriacal Disorder 12 32
Hypochondriacal Neurosis 12
Hypochondria 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12883
ICD9CM 34 300.7
MeSH 43 D006998
NCIt 49 C9493
SNOMED-CT 67 18193002
ICD10 32 F45.2 F45.21
UMLS 71 C0020604

Summaries for Hypochondriasis

Disease Ontology : 12 A somatoform disorder that involves an excessive preoccupation or worry about having a serious illness.

MalaCards based summary : Hypochondriasis, also known as hypochondriacal disorder, is related to somatization disorder and avoidant personality disorder, and has symptoms including mental and behavioral signs and symptoms An important gene associated with Hypochondriasis is NTF3 (Neurotrophin 3), and among its related pathways/superpathways are CREB Pathway and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Fluoxetine and Serotonin Uptake Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and breast, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 74 Hypochondriasis or hypochondria is a condition in which a person is excessively and unduly worried about... more...

Related Diseases for Hypochondriasis

Diseases related to Hypochondriasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
# Related Disease Score Top Affiliating Genes
1 somatization disorder 30.9 SLC6A4 IVL HTR2A HTR1A
2 avoidant personality disorder 30.8 SLC6A4 PIR
3 somatoform disorder 30.7 SLC6A4 HTR3A BDNF
4 depression 30.6 SLC6A4 HTR2A HTR1A BDNF
5 body dysmorphic disorder 30.5 SLITRK1 SLC6A4 HTR2A
6 antisocial personality disorder 30.4 SLC6A4 PIR HTR2A
7 social phobia 30.3 SLC6A4 IVL HTR3A HTR1A
8 personality disorder 30.3 SLC6A4 HTR3A HTR2A HTR1A BDNF
9 agoraphobia 30.2 SLC6A4 PIR IVL HTR2A HTR1A
10 obsessive-compulsive personality disorder 30.2 SLITRK1 SLC6A4 PIR HTR2A
11 neurotic disorder 30.1 SLC6A4 HTR2A HTR1A BDNF
12 anxiety 30.1 SLC6A4 POMC HTR3A HTR2A HTR1A BDNF
13 delusional disorder 29.9 HTR2A HTR1A
14 generalized anxiety disorder 29.9 SLC6A4 HTR3A HTR2A HTR1A BDNF
15 paranoid schizophrenia 29.9 SLC6A4 HTR2A HTR1A BDNF
16 phobia, specific 29.9 SLC6A4 MHRT IVL HTR1A
17 borderline personality disorder 29.7 SLC6A4 HTR3A HTR2A HTR1A BDNF
18 alcohol use disorder 29.6 SLC6A4 HTR3A HTR2A HTR1A BDNF
19 panic disorder 29.6 SLC6A4 POMC NTF3 HTR3A HTR2A HTR1A
20 substance abuse 29.6 SLC6A4 HTR2A HTR1A BDNF
21 obsessive-compulsive disorder 29.5 SLITRK1 SLC6A4 POMC HTR3A HTR2A HTR1A
22 chronic fatigue syndrome 29.5 SLC6A4 POMC HTR3A HTR2A HTR1A
23 mental depression 29.4 SLC6A4 POMC HTR3A HTR2A HTR1A BDNF
24 mood disorder 29.2 SLC6A4 POMC HTR3A HTR2A HTR1A BDNF
25 fibromyalgia 29.2 SLC6A4 POMC HTR3A HTR2A BDNF
26 major depressive disorder 29.1 SLC6A4 POMC HTR3A HTR2A HTR1A BDNF
27 atypical depressive disorder 29.1 SLC6A4 POMC HTR2A HTR1A BDNF
28 dysthymic disorder 29.1 SLC6A4 PIR IVL HTR2A HTR1A BDNF
29 endogenous depression 29.0 SLC6A4 POMC HTR3A HTR2A HTR1A BDNF
30 alcohol dependence 29.0 SLC6A4 POMC HTR3A HTR2A HTR1A BDNF
31 schizophrenia 28.9 SLC6A4 POMC NTF3 HTR3A HTR2A HTR1A
32 phobic disorder 28.5 SLC6A4 PIR MHRT IVL HTR2A HTR1A
33 melancholia 28.4 SLC6A4 POMC HTR2A HTR1A GRAP2 BDNF
34 mononeuritis of lower limb 10.5 NTF4 NTF3
35 lesion of sciatic nerve 10.4 NTF4 NTF3
36 inhibited male orgasm 10.3 SLC6A4 HTR1A
37 deafness, autosomal dominant 33 10.3 SLITRK1 BDNF
38 cataract 38 10.3 NTF4 NTF3
39 schizophrenia 5 10.3 HTR2A HTR1A
40 alcoholic psychosis 10.3 SLC6A4 HTR2A
41 hypoactive sexual desire disorder 10.2 HTR2A HTR1A
42 cyclothymic disorder 10.2 PIR HTR2A
43 kleptomania 10.2 SLITRK1 SLC6A4 HTR1A
44 premature ejaculation 10.2 SLC6A4 HTR3A HTR1A
45 drug psychosis 10.2 HTR2A HTR1A
46 lumbosacral plexus lesion 10.2 NTF4 NTF3 BDNF
47 drug-induced mental disorder 10.2 HTR2A HTR1A
48 conversion disorder 10.2 PIR MEA1
49 sexual masochism 10.2
50 substance-induced psychosis 10.2 HTR2A HTR1A

Comorbidity relations with Hypochondriasis via Phenotypic Disease Network (PDN):


Acute Cystitis Anxiety
Dependent Personality Disorder Dysthymic Disorder
Generalized Anxiety Disorder Hypertension, Essential
Irritable Bowel Syndrome Major Depressive Disorder
Somatization Disorder

Graphical network of the top 20 diseases related to Hypochondriasis:



Diseases related to Hypochondriasis

Symptoms & Phenotypes for Hypochondriasis

UMLS symptoms related to Hypochondriasis:


mental and behavioral signs and symptoms

GenomeRNAi Phenotypes related to Hypochondriasis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.28 HTR1A HTR3A SLC6A4
2 Decreased viability GR00381-A-3 9.28 HTR1A HTR3A SLC6A4
3 Decreased viability GR00402-S-2 9.28 HTR1A HTR3A SLC6A4

MGI Mouse Phenotypes related to Hypochondriasis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.32 BDNF HTR1A HTR2A HTR3A NTF3 NTF4

Drugs & Therapeutics for Hypochondriasis

Drugs for Hypochondriasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluoxetine Approved, Vet_approved Phase 1, Phase 2 54910-89-3 3386
2 Serotonin Uptake Inhibitors Phase 1, Phase 2
3 Neurotransmitter Agents Phase 1, Phase 2
4 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2
5 Psychotropic Drugs Phase 1, Phase 2
6 Cytochrome P-450 CYP2D6 Inhibitors Phase 1, Phase 2
7 Serotonin Agents Phase 1, Phase 2
8 Antidepressive Agents Phase 1, Phase 2
9
Serotonin Investigational, Nutraceutical Phase 1, Phase 2 50-67-9 5202

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Dysfunctional Illness-related Cognitions in Individuals With Hypochondriasis and Change Thereof Completed NCT01119469 Phase 3
2 Treating Refractory Symptoms in Primary Care (Hypochondriasis: Diagnosis, Description and Medical Care) Completed NCT00368212 Phase 3
3 Cognitive-behavioural Therapy Versus Short-term Psychodynamic Psychotherapy: a Randomised Clinical Trial Completed NCT00208247 Phase 2
4 Internet-delivered Cognitive Behavioural Therapy for Health Anxiety - a Randomized Controlled Trial Completed NCT00828152 Phase 2
5 Treatment of Hypochondriasis With CBT and/or SSRI Completed NCT00339079 Phase 1, Phase 2 Fluoxetine;Placebo
6 The Impact of Cardiac Rehabilitation on Angina Frequency, Psychological Morbidity and Quality of Life in Women With Syndrome X Completed NCT00123617 Phase 2
7 An Examination of the Effects of Health-related Internet Use in Individuals With Pathological Health Anxiety in a Randomized Controlled Trial Unknown status NCT03024593
8 Internet-delivered Acceptance and Commitment Therapy for Patients With Health Anxiety: a Randomized Controlled Trial Unknown status NCT02735434
9 Effects of Mindfulness Based Cognitive Therapy on Emotional Processing Unknown status NCT03358056
10 Treatment of Patients With Health Anxiety. A Randomized Controlled Trial of Acceptance and Commitment Therapy (ACT) Group Treatment Compared to a Waiting List Completed NCT01158430
11 Metacognitive Therapy for Health Anxiety: A Randomised Control Trial Completed NCT02404116
12 Cognitive Behavior Therapy vs. Behavioral Stress Management for Severe Health Anxiety: a Randomized Controlled Trial of Two Internet-based Treatments Completed NCT01673035
13 Objective Markers Flatulence: Determination of Gas Production and Evacuation in Response to Dietary Manipulations Completed NCT01291446
14 Follow up of Patients Treated With Cognitive Behavioural Therapy at Clinic for Hypochondriacs, Haraldsplass Deaconal Hospital, From 1997 to 2007 Active, not recruiting NCT00959452
15 Outcome of Cognitive Behavior Therapy for Patients With Severe Health Anxiety Treated in Group Only. A Randomised Controlled Trial. The CHAG-Trial. Categorical and Dimensional Characteristics of Personality Pathology and Predictors of Outcome Active, not recruiting NCT02131883
16 A Pilot Study of Big Mind for Veterans With PTSD Withdrawn NCT02541630

Search NIH Clinical Center for Hypochondriasis

Cochrane evidence based reviews: hypochondriasis

Genetic Tests for Hypochondriasis

Anatomical Context for Hypochondriasis

MalaCards organs/tissues related to Hypochondriasis:

40
Brain, Testes, Breast, Heart, Colon, Spinal Cord, Liver

Publications for Hypochondriasis

Articles related to Hypochondriasis:

(show top 50) (show all 1301)
# Title Authors PMID Year
1
[Serotonin type 2a (5-HTR2A) receptor gene polymorphism and personality traits in patients with endogenous psychoses]. 54 61
11421130 2001
2
DSM-5 Personality Disorders and Traits in Patients With Severe Health Anxiety. 61
31821216 2020
3
Illness-related intrusive thoughts and illness anxiety disorder. 61
31957211 2020
4
Medical Maximizing-Minimizing Predicts Patient Preferences for High- and Low-Benefit Care. 61
31975657 2020
5
Cognitive behavior therapy for health anxiety: systematic review and meta-analysis of clinical efficacy and health economic outcomes. 61
31859542 2019
6
The assessment of cognitive-behavioral therapy skills in patients diagnosed with health anxiety: Development and pilot study on an observer-based rating scale. 61
31218759 2019
7
Cushing's disease: a prospective case-control study of health-related quality of life and cognitive status before and after surgery. 61
31731265 2019
8
Somatic symptom disorder: a diagnostic dilemma. 61
31772129 2019
9
Dysfunctional beliefs as mediators between illness-related intrusive thoughts and health anxiety symptoms. 61
31597585 2019
10
Relationship between VEGF-related gene polymorphisms and brain morphology in treatment-naïve patients with first-episode major depressive disorder. 61
30406404 2019
11
Clinical and psychological characteristics of patients with globus. 61
30772327 2019
12
Revalidation of Adjustment Disorder-New Module-4 screening of adjustment disorder in a non-clinical sample: Psychometric reevaluation and correlates with other ICD-11 mental disorders. 61
30983131 2019
13
The Spanish validation of the Short Health Anxiety Inventory: Psychometric properties and clinical utility. 61
31516503 2019
14
Hypochondriasis in the elderly and Lewy body disease. 61
30761685 2019
15
Smaller Pituitary Volumes in Patients with Delusional Disorder. 61
31762560 2019
16
Data on gray matter alterations in anxious depression. 61
31453297 2019
17
A loneliness model of hypochondriasis among older adults: The mediating role of intolerance of uncertainty and anxious symptoms. 61
30974401 2019
18
Psychological profiles in patients undergoing orthognathic surgery or rhinoplasty: a preoperative and preliminary comparison. 61
31016403 2019
19
Strengthening competence of therapists-in-training in the treatment of health anxiety (hypochondriasis): Validation of the Assessment of Core CBT Skills (ACCS). 61
30793415 2019
20
The cross-cultural and transdiagnostic nature of unwanted mental intrusions. 61
31193125 2019
21
Hypochondriasis: Clinical Profile in a Tertiary Care Psychiatry and Neurosciences Hospital in Southern India - A Retrospective Chart Review. 61
30983668 2019
22
Correlates of worry and functional somatic symptoms in generalized anxiety disorder. 61
31879444 2019
23
Severe Illness Anxiety Treated by Integrating Inpatient Psychotherapy With Medical Care and Minimizing Reassurance. 61
30967801 2019
24
Videoconferencing psychological therapy and anxiety: a systematic review. 61
30188992 2019
25
[Neurophysiological peculiarities of cognitive activity in patients anxiety-depressive and hypochondriacal disorders]. 61
31089094 2019
26
Prevalence of hypochondriac symptoms among health science students in China: A systematic review and meta-analysis. 61
31527902 2019
27
Death anxiety and its association with hypochondriasis and medically unexplained symptoms: A systematic review. 61
30470318 2018
28
Predicting patient reassurance after colonoscopy: The role of illness beliefs. 61
30314580 2018
29
Toward a Lifestyle Medicine Approach to Illness Anxiety Disorder (Formerly Hypochondriasis). 61
30283260 2018
30
Recent Advances in the Understanding and Treatment of Health Anxiety. 61
29931576 2018
31
Development and Feasibility Testing of Internet-Delivered Acceptance and Commitment Therapy for Severe Health Anxiety: Pilot Study. 61
29625957 2018
32
Treatment course and its predictors in patients with somatoform disorders: A routine outcome monitoring study in secondary psychiatric care. 61
29573030 2018
33
Metacognitive beliefs as a predictor of health anxiety in a self-reporting Italian clinical sample. 61
29226504 2018
34
Multidimensional approach usefulness in early Alzheimer's disease: Advances in clinical practice. 61
29633747 2018
35
Comparisons between the Minnesota Multiphasic Personality Inventory-Adolescent-Restructured Form (MMPI-A RF) and MMPI-A in adolescent psychiatric inpatients. 61
28425726 2018
36
Outcome of day treatment for older adults with affective disorders: An observational pre-post design of two transdiagnostic approaches. 61
28967157 2018
37
Residual anxiety may be associated with depressive relapse during continuation therapy of bipolar II depression. 61
29149756 2018
38
Somatosensory amplification, health anxiety, and alexithymia in generalized anxiety disorder. 61
30416291 2018
39
Functional links of obsessive, dysmorphic, hypochondriac, and eating-disorders related mental intrusions. 61
30487909 2018
40
The Use of Antidepressants for Physical and Psychological Symptoms in Cancer. 61
29484993 2018
41
Differences in clinical intrusive thoughts between obsessive-compulsive disorder, generalized anxiety disorder, and hypochondria. 61
28744937 2017
42
Emotion dysregulation in hypochondriasis and depression. 61
28444850 2017
43
Body dysmorphic disorder: history and curiosities. 61
28220373 2017
44
DSM-5 illness anxiety disorder and somatic symptom disorder: Comorbidity, correlates, and overlap with DSM-IV hypochondriasis. 61
28867421 2017
45
Cognitive therapy and exposure therapy for hypochondriasis (health anxiety): A 3-year naturalistic follow-up. 61
28956951 2017
46
Cognitive-behaviour therapy for health anxiety in medical patients (CHAMP): a randomised controlled trial with outcomes to 5 years. 61
28877841 2017
47
New Insights on the Treatment of Hypochondriasis. 61
28760014 2017
48
A Randomized Controlled Trial of Medication and Cognitive-Behavioral Therapy for Hypochondriasis. 61
28659038 2017
49
Personality Disorders in Hypochondriasis: A Comparison to Panic Disorder and Healthy Controls. 61
27749185 2017
50
The influence of interoceptive awareness on functional connectivity in patients with irritable bowel syndrome. 61
27704405 2017

Variations for Hypochondriasis

Expression for Hypochondriasis

Search GEO for disease gene expression data for Hypochondriasis.

Pathways for Hypochondriasis

GO Terms for Hypochondriasis

Cellular components related to Hypochondriasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.65 NTF4 NTF3 HTR2A HTR1A BDNF
2 synaptic vesicle GO:0008021 9.5 NTF4 NTF3 BDNF
3 integral component of presynaptic membrane GO:0099056 9.33 SLC6A4 HTR3A HTR2A
4 integral component of postsynaptic membrane GO:0099055 9.13 SLC6A4 HTR3A HTR2A
5 axon GO:0030424 9.02 NTF4 NTF3 HTR3A HTR2A BDNF

Biological processes related to Hypochondriasis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron apoptotic process GO:0043524 9.71 NTF4 NTF3 BDNF
2 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.69 NTF4 NTF3 BDNF
3 modulation of chemical synaptic transmission GO:0050804 9.63 NTF4 NTF3 BDNF
4 neuron projection morphogenesis GO:0048812 9.61 NTF4 NTF3 BDNF
5 activation of phospholipase C activity GO:0007202 9.58 NTF4 HTR2A BDNF
6 regulation of neuron differentiation GO:0045664 9.54 NTF4 NTF3 BDNF
7 neurotrophin TRK receptor signaling pathway GO:0048011 9.52 NTF4 BDNF
8 peripheral nervous system development GO:0007422 9.5 NTF4 NTF3 BDNF
9 vasoconstriction GO:0042310 9.49 SLC6A4 HTR1A
10 behavior GO:0007610 9.48 HTR2A HTR1A
11 nerve development GO:0021675 9.43 NTF4 NTF3 BDNF
12 nerve growth factor signaling pathway GO:0038180 9.33 NTF4 NTF3 BDNF
13 serotonin receptor signaling pathway GO:0007210 9.13 HTR3A HTR2A HTR1A
14 memory GO:0007613 9.02 SLC6A4 NTF4 NTF3 HTR2A BDNF

Molecular functions related to Hypochondriasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serotonin binding GO:0051378 8.92 SLC6A4 HTR3A HTR2A HTR1A

Sources for Hypochondriasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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