MCID: HYP016
MIFTS: 47

Hypochondriasis

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Hypochondriasis

MalaCards integrated aliases for Hypochondriasis:

Name: Hypochondriasis 12 74 54 43 15 71
Hypochondriacal Disorder 12 32
Hypochondriacal Neurosis 12
Hypochondria 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12883
ICD9CM 34 300.7
MeSH 43 D006998
NCIt 49 C9493
SNOMED-CT 67 18193002
ICD10 32 F45.2 F45.21
UMLS 71 C0020604

Summaries for Hypochondriasis

Disease Ontology : 12 A somatoform disorder that involves an excessive preoccupation or worry about having a serious illness.

MalaCards based summary : Hypochondriasis, also known as hypochondriacal disorder, is related to somatization disorder and avoidant personality disorder, and has symptoms including mental and behavioral signs and symptoms An important gene associated with Hypochondriasis is NTF3 (Neurotrophin 3), and among its related pathways/superpathways are CREB Pathway and G-Beta Gamma Signaling. The drugs Fluoxetine and Cytochrome P-450 Enzyme Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and breast, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 74 Hypochondriasis or hypochondria is a condition in which a person is excessively and unduly worried about... more...

Related Diseases for Hypochondriasis

Diseases related to Hypochondriasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 somatization disorder 31.4 SLC6A4 MHRT HTR2A
2 avoidant personality disorder 30.8 SLC6A4 PIR
3 somatoform disorder 30.6 SLC6A4 HTR3A BDNF
4 body dysmorphic disorder 30.4 SLITRK1 SLC6A4 PIR HTR2A
5 obsessive-compulsive personality disorder 30.2 SLITRK1 SLC6A4 PIR HTR2A
6 neurotic disorder 30.1 SLC6A4 HTR2A HTR1A BDNF
7 antisocial personality disorder 29.9 SLC6A4 PIR HTR2A CFI
8 paranoid schizophrenia 29.9 SLC6A4 HTR2A HTR1A BDNF
9 depression 29.7 SLC6A4 HTR2C HTR2A HTR1A BDNF
10 phobia, specific 29.7 SLC6A4 MHRT IVL HTR1A CFI
11 chronic fatigue syndrome 29.6 SLC6A4 POMC HTR3A HTR2A HTR1A
12 delusional disorder 29.4 HTR2C HTR2A HTR1A
13 personality disorder 29.3 SLC6A4 HTR3A HTR2C HTR2A HTR1A BDNF
14 atypical depressive disorder 29.2 SLC6A4 POMC HTR2A HTR1A BDNF
15 agoraphobia 29.2 SLC6A4 PIR IVL HTR2A HTR1A CFI
16 substance abuse 29.2 SLC6A4 POMC HTR2A HTR1A BDNF
17 endogenous depression 29.1 SLC6A4 POMC HTR3A HTR2A HTR1A BDNF
18 social phobia 29.0 SLC6A4 MHRT IVL HTR3A HTR1A CFI
19 generalized anxiety disorder 29.0 SLC6A4 HTR3A HTR2C HTR2A HTR1A BDNF
20 fibromyalgia 28.9 SLC6A4 POMC HTR3A HTR2A HTR1A BDNF
21 panic disorder 28.8 SLC6A4 POMC NTF3 HTR3A HTR2C HTR2A
22 obsessive-compulsive disorder 28.7 SLITRK1 SLC6A4 POMC HTR3A HTR2C HTR2A
23 borderline personality disorder 28.7 SLC6A4 HTR3A HTR2C HTR2A HTR1A BDNF
24 anxiety 28.7 SLC6A4 POMC HTR3A HTR2C HTR2A HTR1A
25 alcohol use disorder 28.7 SLC6A4 HTR3A HTR2C HTR2A HTR1A BDNF
26 melancholia 28.6 SLC6A4 POMC MHRT HTR2A HTR1A GRAP2
27 mental depression 28.6 SLC6A4 POMC HTR3A HTR2C HTR2A HTR1A
28 dysthymic disorder 28.5 SLC6A4 PIR IVL HTR2A HTR1A CFI
29 mood disorder 28.3 SLC6A4 POMC HTR3A HTR2C HTR2A HTR1A
30 major depressive disorder 28.3 SLC6A4 POMC HTR3A HTR2C HTR2A HTR1A
31 alcohol dependence 28.1 SLC6A4 POMC HTR3A HTR2C HTR2A HTR1A
32 schizophrenia 28.1 SLC6A4 POMC NTF3 HTR3A HTR2C HTR2A
33 phobic disorder 27.8 SLC6A4 POMC PIR MHRT IVL HTR2A
34 mononeuritis of lower limb 10.4 NTF4 NTF3
35 alcoholic psychosis 10.3 SLC6A4 HTR2A
36 cataract 38 10.3 NTF4 NTF3
37 outlet dysfunction constipation 10.3 SLC6A4 HTR3A
38 deafness, autosomal dominant 33 10.2 SLITRK1 BDNF
39 kleptomania 10.2 SLITRK1 SLC6A4 HTR1A
40 drug psychosis 10.2 HTR2A HTR1A
41 drug-induced mental disorder 10.2 HTR2A HTR1A
42 serous labyrinthitis 10.2 NTF4 NTF3
43 sexual masochism 10.2
44 cyclothymic disorder 10.2 PIR HTR2A
45 alexithymia 10.2
46 physical disorder 10.2
47 severe combined immunodeficiency 10.2
48 narcissistic personality disorder 10.2 PIR CFI
49 substance-induced psychosis 10.2 HTR2A HTR1A
50 exhibitionism 10.2 PIR CFI

Comorbidity relations with Hypochondriasis via Phenotypic Disease Network (PDN):


Acute Cystitis Anxiety
Dependent Personality Disorder Dysthymic Disorder
Generalized Anxiety Disorder Hypertension, Essential
Irritable Bowel Syndrome Major Depressive Disorder
Somatization Disorder

Graphical network of the top 20 diseases related to Hypochondriasis:



Diseases related to Hypochondriasis

Symptoms & Phenotypes for Hypochondriasis

UMLS symptoms related to Hypochondriasis:


mental and behavioral signs and symptoms

GenomeRNAi Phenotypes related to Hypochondriasis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00249-S 9.28 SLC6A4
2 Decreased viability GR00381-A-1 9.28 HTR1A HTR3A SLC6A4
3 Decreased viability GR00381-A-3 9.28 HTR1A HTR3A SLC6A4
4 Decreased viability GR00402-S-2 9.28 HTR1A HTR3A

MGI Mouse Phenotypes related to Hypochondriasis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.9 BDNF HTR1A HTR2A HTR2C HTR3A NTF3
2 growth/size/body region MP:0005378 9.7 BDNF HNRNPU HTR2C HTR3A NTF3 NTF4
3 nervous system MP:0003631 9.32 BDNF HTR1A HTR2C HTR3A NTF3 NTF4

Drugs & Therapeutics for Hypochondriasis

Drugs for Hypochondriasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluoxetine Approved, Vet_approved Phase 1, Phase 2 54910-89-3 3386
2 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2
3 Neurotransmitter Agents Phase 1, Phase 2
4 Antidepressive Agents Phase 1, Phase 2
5 Serotonin Uptake Inhibitors Phase 1, Phase 2
6 Psychotropic Drugs Phase 1, Phase 2
7
Serotonin Investigational, Nutraceutical Phase 1, Phase 2 50-67-9 5202

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Dysfunctional Illness-related Cognitions in Individuals With Hypochondriasis and Change Thereof Completed NCT01119469 Phase 3
2 Treating Refractory Symptoms in Primary Care (Hypochondriasis: Diagnosis, Description and Medical Care) Completed NCT00368212 Phase 3
3 Cognitive-behavioural Therapy Versus Short-term Psychodynamic Psychotherapy: a Randomised Clinical Trial Completed NCT00208247 Phase 2
4 Internet-delivered Cognitive Behavioural Therapy for Health Anxiety - a Randomized Controlled Trial Completed NCT00828152 Phase 2
5 Treatment of Hypochondriasis With CBT and/or SSRI Completed NCT00339079 Phase 1, Phase 2 Fluoxetine;Placebo
6 The Impact of Cardiac Rehabilitation on Angina Frequency, Psychological Morbidity and Quality of Life in Women With Syndrome X Completed NCT00123617 Phase 2
7 An Examination of the Effects of Health-related Internet Use in Individuals With Pathological Health Anxiety in a Randomized Controlled Trial Unknown status NCT03024593
8 Internet-delivered Acceptance and Commitment Therapy for Patients With Health Anxiety: a Randomized Controlled Trial Unknown status NCT02735434
9 Effects of Mindfulness Based Cognitive Therapy on Emotional Processing Unknown status NCT03358056
10 Treatment of Patients With Health Anxiety. A Randomized Controlled Trial of Acceptance and Commitment Therapy (ACT) Group Treatment Compared to a Waiting List Completed NCT01158430
11 Metacognitive Therapy for Health Anxiety: A Randomised Control Trial Completed NCT02404116
12 Cognitive Behavior Therapy vs. Behavioral Stress Management for Severe Health Anxiety: a Randomized Controlled Trial of Two Internet-based Treatments Completed NCT01673035
13 Outcome of Cognitive Behavior Therapy for Patients With Severe Health Anxiety Treated in Group Only. A Randomised Controlled Trial. The CHAG-Trial. Categorical and Dimensional Characteristics of Personality Pathology and Predictors of Outcome Completed NCT02131883
14 Objective Markers Flatulence: Determination of Gas Production and Evacuation in Response to Dietary Manipulations Completed NCT01291446
15 Follow up of Patients Treated With Cognitive Behavioural Therapy at Clinic for Hypochondriacs, Haraldsplass Deaconal Hospital, From 1997 to 2007 Active, not recruiting NCT00959452
16 A Randomized Controlled Trial Comparing the Efficacy of Therapist Guided Internet-delivered Cognitive Therapy (TG-iConquerFear) With Augmented Treatment as Usual in Reducing Fear of Cancer Recurrence in Danish Colorectal Cancer Survivors Not yet recruiting NCT04287218
17 A Pilot Study of Big Mind for Veterans With PTSD Withdrawn NCT02541630

Search NIH Clinical Center for Hypochondriasis

Cochrane evidence based reviews: hypochondriasis

Genetic Tests for Hypochondriasis

Anatomical Context for Hypochondriasis

MalaCards organs/tissues related to Hypochondriasis:

40
Testes, Brain, Breast, Heart, Colon, Spinal Cord, Liver

Publications for Hypochondriasis

Articles related to Hypochondriasis:

(show top 50) (show all 1315)
# Title Authors PMID Year
1
[Serotonin type 2a (5-HTR2A) receptor gene polymorphism and personality traits in patients with endogenous psychoses]. 54 61
11421130 2001
2
Psychiatric characteristics of older persons with medically unexplained symptoms: A comparison with older patients suffering from medically explained symptoms. 61
32431253 2020
3
Is cyberchondria a new transdiagnostic digital compulsive syndrome? A systematic review of the evidence. 61
32146315 2020
4
Why health anxiety needs to be recognised in hospital practice. 61
32414727 2020
5
Dysfunctional beliefs as mediators between illness-related intrusive thoughts and health anxiety symptoms. 61
31597585 2020
6
A comparison of patients with somatic symptom disorder attending psychiatric services and those unwilling to attend psychiatric services. 61
32474346 2020
7
The Influence of Socio-Demographic Factors, Lifestyle and Psychiatric Indicators on Adherence to Treatment of Patients with Rheumatoid Arthritis: A Cross-Sectional Study. 61
32295226 2020
8
Long-term effect of cognitive-behavioural therapy in patients with Hypochondriacal Disorder. 61
32345417 2020
9
Mental disorders and total mortality after 20 years in an adult general population sample. 61
32115002 2020
10
Relationships Between Somatic Symptoms and Panic-Agoraphobic Spectrum Among Frequent Attenders of the General Practice in Italy. 61
32205774 2020
11
Sustained benefit of cognitive behaviour therapy for health anxiety in medical patients (CHAMP) over 8 years: a randomised-controlled trial. 61
32174296 2020
12
Impact of Endoscopists' Personality Traits on Adenoma and Polyp Detection Rates in Colonoscopy: A KASID Multicenter Study. 61
32157497 2020
13
DSM-5 Personality Disorders and Traits in Patients With Severe Health Anxiety. 61
31821216 2020
14
A Comparative Study of Health Anxiety in Neurology and Psychiatry Settings. 61
32140015 2020
15
Illness-related intrusive thoughts and illness anxiety disorder. 61
31957211 2020
16
Psychological Characteristics in Patients with Chronic Complex Regional Pain Syndrome: Comparisons with Patients with Major Depressive Disorder and Other Types of Chronic Pain. 61
32104060 2020
17
Impact of nickel oral hyposensitization on quality of life in systemic nickel allergy syndrome. 61
32567420 2020
18
Medical Maximizing-Minimizing Predicts Patient Preferences for High- and Low-Benefit Care. 61
31975657 2020
19
Cognitive behavior therapy for health anxiety: systematic review and meta-analysis of clinical efficacy and health economic outcomes. 61
31859542 2019
20
The assessment of cognitive-behavioral therapy skills in patients diagnosed with health anxiety: Development and pilot study on an observer-based rating scale. 61
31218759 2019
21
Cushing's disease: a prospective case-control study of health-related quality of life and cognitive status before and after surgery. 61
31731265 2019
22
Somatic symptom disorder: a diagnostic dilemma. 61
31772129 2019
23
Relationship between VEGF-related gene polymorphisms and brain morphology in treatment-naïve patients with first-episode major depressive disorder. 61
30406404 2019
24
Clinical and psychological characteristics of patients with globus. 61
30772327 2019
25
The Spanish validation of the Short Health Anxiety Inventory: Psychometric properties and clinical utility. 61
31516503 2019
26
Hypochondriasis in the elderly and Lewy body disease. 61
30761685 2019
27
Revalidation of Adjustment Disorder-New Module-4 screening of adjustment disorder in a non-clinical sample: Psychometric reevaluation and correlates with other ICD-11 mental disorders. 61
30983131 2019
28
Smaller Pituitary Volumes in Patients with Delusional Disorder. 61
31762560 2019
29
Data on gray matter alterations in anxious depression. 61
31453297 2019
30
A loneliness model of hypochondriasis among older adults: The mediating role of intolerance of uncertainty and anxious symptoms. 61
30974401 2019
31
Psychological profiles in patients undergoing orthognathic surgery or rhinoplasty: a preoperative and preliminary comparison. 61
31016403 2019
32
Strengthening competence of therapists-in-training in the treatment of health anxiety (hypochondriasis): Validation of the Assessment of Core CBT Skills (ACCS). 61
30793415 2019
33
The cross-cultural and transdiagnostic nature of unwanted mental intrusions. 61
31193125 2019
34
Hypochondriasis: Clinical Profile in a Tertiary Care Psychiatry and Neurosciences Hospital in Southern India - A Retrospective Chart Review. 61
30983668 2019
35
[Neurophysiological peculiarities of cognitive activity in patients anxiety-depressive and hypochondriacal disorders]. 61
31089094 2019
36
Severe Illness Anxiety Treated by Integrating Inpatient Psychotherapy With Medical Care and Minimizing Reassurance. 61
30967801 2019
37
Correlates of worry and functional somatic symptoms in generalized anxiety disorder. 61
31879444 2019
38
Videoconferencing psychological therapy and anxiety: a systematic review. 61
30188992 2019
39
Prevalence of hypochondriac symptoms among health science students in China: A systematic review and meta-analysis. 61
31527902 2019
40
Death anxiety and its association with hypochondriasis and medically unexplained symptoms: A systematic review. 61
30470318 2018
41
Predicting patient reassurance after colonoscopy: The role of illness beliefs. 61
30314580 2018
42
Toward a Lifestyle Medicine Approach to Illness Anxiety Disorder (Formerly Hypochondriasis). 61
30283260 2018
43
Recent Advances in the Understanding and Treatment of Health Anxiety. 61
29931576 2018
44
Development and Feasibility Testing of Internet-Delivered Acceptance and Commitment Therapy for Severe Health Anxiety: Pilot Study. 61
29625957 2018
45
Treatment course and its predictors in patients with somatoform disorders: A routine outcome monitoring study in secondary psychiatric care. 61
29573030 2018
46
Metacognitive beliefs as a predictor of health anxiety in a self-reporting Italian clinical sample. 61
29226504 2018
47
Multidimensional approach usefulness in early Alzheimer's disease: Advances in clinical practice. 61
29633747 2018
48
Comparisons between the Minnesota Multiphasic Personality Inventory-Adolescent-Restructured Form (MMPI-A RF) and MMPI-A in adolescent psychiatric inpatients. 61
28425726 2018
49
Outcome of day treatment for older adults with affective disorders: An observational pre-post design of two transdiagnostic approaches. 61
28967157 2018
50
Residual anxiety may be associated with depressive relapse during continuation therapy of bipolar II depression. 61
29149756 2018

Variations for Hypochondriasis

Expression for Hypochondriasis

Search GEO for disease gene expression data for Hypochondriasis.

Pathways for Hypochondriasis

Pathways related to Hypochondriasis according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.94 NTF4 NTF3 HTR3A HTR2C HTR2A HTR1A
2
Show member pathways
12.79 POMC IVL HTR2C HTR2A BDNF
3 11.76 SLC6A4 HTR3A HTR2A HTR1A BDNF
4
Show member pathways
11.69 HTR2C HTR2A HTR1A
5
Show member pathways
11.52 NTF4 NTF3 BDNF
6 11.48 NTF4 NTF3 BDNF
7 11.45 NTF4 NTF3 GRAP2 BDNF
8 11.41 SLC6A4 HTR3A HTR2C HTR2A HTR1A
9
Show member pathways
11.36 NTF4 NTF3 BDNF
10
Show member pathways
11.28 NTF4 NTF3 BDNF
11
Show member pathways
10.9 SLC6A4 HTR1A
12 10.81 HTR2C HTR2A
13 10.8 POMC HTR2C
14 10.47 SLC6A4 HTR3A HTR2C HTR2A HTR1A

GO Terms for Hypochondriasis

Cellular components related to Hypochondriasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 synapse GO:0045202 9.8 SLITRK1 SLC6A4 HTR3A HTR2C HTR2A HTR1A
2 integral component of presynaptic membrane GO:0099056 9.43 SLC6A4 HTR3A HTR2A
3 axon GO:0030424 9.35 NTF4 NTF3 HTR3A HTR2A BDNF
4 integral component of postsynaptic membrane GO:0099055 9.33 SLC6A4 HTR3A HTR2A
5 dendrite GO:0030425 9.1 NTF4 NTF3 HTR2C HTR2A HTR1A BDNF

Biological processes related to Hypochondriasis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.19 POMC NTF4 NTF3 HTR3A HTR2C HTR2A
2 response to drug GO:0042493 9.9 SLC6A4 HTR2C HTR2A BDNF
3 chemical synaptic transmission GO:0007268 9.87 HTR3A HTR2C HTR2A HTR1A
4 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.79 NTF4 NTF3 BDNF
5 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.77 NTF4 NTF3 BDNF
6 modulation of chemical synaptic transmission GO:0050804 9.75 NTF4 NTF3 BDNF
7 neuron projection morphogenesis GO:0048812 9.73 NTF4 NTF3 BDNF
8 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.72 HTR2C HTR2A HTR1A
9 regulation of neuron differentiation GO:0045664 9.67 NTF4 NTF3 BDNF
10 behavioral fear response GO:0001662 9.65 HTR2C HTR1A BDNF
11 activation of phospholipase C activity GO:0007202 9.63 NTF4 HTR2A BDNF
12 neurotrophin TRK receptor signaling pathway GO:0048011 9.61 NTF4 BDNF
13 vasoconstriction GO:0042310 9.61 SLC6A4 HTR1A
14 peripheral nervous system development GO:0007422 9.61 NTF4 NTF3 BDNF
15 regulation of appetite GO:0032098 9.54 POMC HTR2C
16 mechanoreceptor differentiation GO:0042490 9.52 NTF4 BDNF
17 positive regulation of phosphatidylinositol biosynthetic process GO:0010513 9.51 HTR2C HTR2A
18 nerve development GO:0021675 9.5 NTF4 NTF3 BDNF
19 behavior GO:0007610 9.43 HTR2C HTR2A HTR1A
20 taste bud development GO:0061193 9.4 NTF4 BDNF
21 phospholipase C-activating serotonin receptor signaling pathway GO:0007208 9.37 HTR2C HTR2A
22 memory GO:0007613 9.35 SLC6A4 NTF4 NTF3 HTR2A BDNF
23 nerve growth factor signaling pathway GO:0038180 9.33 NTF4 NTF3 BDNF
24 serotonin receptor signaling pathway GO:0007210 8.92 HTR3A HTR2C HTR2A HTR1A

Molecular functions related to Hypochondriasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled serotonin receptor activity GO:0004993 9.5 HTR2C HTR2A HTR1A
2 neurotransmitter receptor activity GO:0030594 9.46 HTR3A HTR2C HTR2A HTR1A
3 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding GO:0071886 9.26 HTR2C HTR2A
4 nerve growth factor receptor binding GO:0005163 9.13 NTF4 NTF3 BDNF
5 serotonin binding GO:0051378 9.02 SLC6A4 HTR3A HTR2C HTR2A HTR1A

Sources for Hypochondriasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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