MCID: HYP001
MIFTS: 36

Hypochromic Microcytic Anemia

Categories: Blood diseases

Aliases & Classifications for Hypochromic Microcytic Anemia

MalaCards integrated aliases for Hypochromic Microcytic Anemia:

Name: Hypochromic Microcytic Anemia 12 38 30 13 15
Anemia, Hypochromic Microcytic 13 56
Microcytic Hypochromic Anemia 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0050642
KEGG 38 H01196
UMLS 74 C0271901

Summaries for Hypochromic Microcytic Anemia

Disease Ontology : 12 A microcytic anemia characterized by paler than normal blood cells.

MalaCards based summary : Hypochromic Microcytic Anemia, also known as anemia, hypochromic microcytic, is related to hypochromic microcytic anemia with iron overload and hemosiderosis. An important gene associated with Hypochromic Microcytic Anemia is SLC11A2 (Solute Carrier Family 11 Member 2), and among its related pathways/superpathways are Lysosome and Mineral absorption. The drugs Iron and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Hypochromic Microcytic Anemia

Diseases related to Hypochromic Microcytic Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 hypochromic microcytic anemia with iron overload 34.5 SLC11A2 STEAP3
2 hemosiderosis 30.7 CP SLC11A2
3 iron metabolism disease 30.5 CP SLC11A2
4 iron deficiency anemia 30.4 SLC11A2 TMPRSS6
5 atransferrinemia 30.4 CP SLC11A2
6 microcytic anemia 30.2 HBA1 HBA2 SLC11A2 STEAP3 TMPRSS6
7 thalassemia 29.9 HBA1 HBA2 HBB
8 alpha-thalassemia 29.6 HBA1 HBA2 HBB
9 deficiency anemia 29.2 CP HBA2 HBB SLC11A2 TMPRSS6
10 iron-refractory iron deficiency anemia 12.1
11 anemia, hypochromic microcytic, with iron overload 2 11.7
12 anemia, hypochromic microcytic, with iron overload 1 11.5
13 fetal hemoglobin quantitative trait locus 1 11.4
14 anemia, sideroblastic, 1 11.4
15 anemia, sideroblastic, and spinocerebellar ataxia 11.4
16 majeed syndrome 11.4
17 celiac disease 1 10.2
18 metal metabolism disorder 10.1 CP SLC11A2
19 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 10.0 HBA1 HBA2
20 diabetes mellitus, insulin-dependent, 24 10.0 HBA1 HBA2
21 hydrops fetalis, nonimmune 10.0 HBA1 HBA2
22 hydrops fetalis 10.0 HBA1 HBA2
23 hypoglycemic coma 10.0 HBA1 HBA2
24 erythrocytosis, familial, 7 10.0 HBA1 HBA2
25 type 1 diabetes mellitus 7 10.0 HBA1 HBA2
26 type 1 diabetes mellitus 11 10.0 HBA1 HBA2
27 immature cataract 9.9 HBA1 HBA2
28 nutritional deficiency disease 9.9 CP TMPRSS6
29 hemochromatosis, type 1 9.9 CP SLC11A2 TMPRSS6
30 retinal vascular disease 9.9 HBA1 HBA2
31 hemoglobin zurich 9.8 HBA2 HBB
32 rubeosis iridis 9.8 HBA2 HBB
33 glucose metabolism disease 9.7 HBA1 HBA2
34 sickle cell disease 9.7 HBA2 HBB
35 congenital hemolytic anemia 9.6 HBA2 HBB
36 methemoglobinemia, beta-globin type 9.5 HBA1 HBA2 HBB
37 glutathione peroxidase deficiency 9.5 HBA1 HBA2 HBB
38 heinz body anemias 9.5 HBA1 HBA2 HBB
39 alpha thalassemia-intellectual disability syndrome type 1 9.5 HBA1 HBA2 HBB
40 hemoglobin h disease 9.5 HBA1 HBA2 HBB
41 hemoglobinopathy 9.5 HBA1 HBA2 HBB
42 sickle cell anemia 9.5 HBA1 HBA2 HBB
43 beta-thalassemia 9.5 HBA1 HBA2 HBB
44 hemolytic anemia 9.5 HBA1 HBA2 HBB
45 malaria 9.1 HBA1 HBA2 HBB

Graphical network of the top 20 diseases related to Hypochromic Microcytic Anemia:



Diseases related to Hypochromic Microcytic Anemia

Symptoms & Phenotypes for Hypochromic Microcytic Anemia

GenomeRNAi Phenotypes related to Hypochromic Microcytic Anemia according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.23 HBA1 HBA2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.23 HBA1 HBA2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.23 HBA1 HBA2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.23 HBA1 HBA2

MGI Mouse Phenotypes related to Hypochromic Microcytic Anemia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 8.92 CP SLC11A2 STEAP3 TMPRSS6

Drugs & Therapeutics for Hypochromic Microcytic Anemia

Drugs for Hypochromic Microcytic Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved, Experimental Phase 4,Not Applicable 7439-89-6, 15438-31-0 23925 27284
2 Anti-Infective Agents Phase 4
3 Iron Supplement Phase 4
4 Lactoferrin Phase 4
5 Micronutrients ,Not Applicable
6 Trace Elements ,Not Applicable
7 Nutrients ,Not Applicable
8 ferric gluconate Not Applicable
9 Ferric Compounds Not Applicable
10 Hematinics Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Bovine Lactoferrin Versus Ferrous Sulphate In The Treatment Of Iron Deficiency Anemia During Pregnancy Recruiting NCT03202615 Phase 4 F (ferrous sulphate)
2 Detection Of β-thalassemia Carriers In Assiut Not yet recruiting NCT03822585 Not Applicable
3 Red Cell Distribution Width Index Versus Red Cell Distribution Width as Discriminating Guide for Iron Deficiency Anaemia and Beta Thalassemia Trait . Not yet recruiting NCT03868306
4 Detection of β Thalassemia Carriers by Red Cell Parameters Obtained From the H2 Automatic Counter Enrolling by invitation NCT00481221
5 Comparing the Efficacy of Different Iron Formulations: Sucrosomal Ferric Pyrophosphate, SunActive®Fe and Intravenous Ferric Gluconate Completed NCT03771092 Not Applicable

Search NIH Clinical Center for Hypochromic Microcytic Anemia

Genetic Tests for Hypochromic Microcytic Anemia

Genetic tests related to Hypochromic Microcytic Anemia:

# Genetic test Affiliating Genes
1 Hypochromic Microcytic Anemia 30

Anatomical Context for Hypochromic Microcytic Anemia

MalaCards organs/tissues related to Hypochromic Microcytic Anemia:

42
Liver, Bone, Bone Marrow

Publications for Hypochromic Microcytic Anemia

Articles related to Hypochromic Microcytic Anemia:

(show all 18)
# Title Authors Year
1
Hereditary hypochromic microcytic anemia associated with loss-of-function DMT1 gene mutations and absence of liver iron overload. ( 29178181 )
2018
2
Causes of Hypochromic Microcytic Anemia in Children and Evaluation of Laboratory Parameters in the Differentiation. ( 30557168 )
2018
3
Evaluation of Alpha-Thalassemia Mutations in Cases with Hypochromic Microcytic Anemia: The A^stanbul Perspective. ( 26377141 )
2015
4
Hypochromic microcytic anemia with a variant hemoglobin. ( 19006231 )
2009
5
Severe hypochromic microcytic anemia in a patient with congenital atransferrinemia. ( 19579082 )
2009
6
hem6: an ENU-induced recessive hypochromic microcytic anemia mutation in the mouse. ( 18780836 )
2008
7
Hypochromic microcytic anemia as a clinical presentation of celiac disease. ( 16812948 )
2006
8
nm1054: a spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse. ( 15994289 )
2005
9
A 16-year-old girl with hypochromic microcytic anemia. ( 16253038 )
2005
10
Severe hypochromic microcytic anemia caused by a congenital defect of the iron transport pathway in erythroid cells. ( 15121718 )
2004
11
Ferrochelatase deficiency in the bone marrow in a syndrome of congenital hypochromic microcytic anemia, hyperferremia, and iron overload of the liver. ( 3856939 )
1985
12
Transferrin loss into the urine with hypochromic, microcytic anemia. ( 1246990 )
1976
13
Hereditary hypochromic microcytic anemia in the laboratory rat. ( 5958911 )
1966
14
MILK-INDUCED GASTROINTESTINAL BLEEDING IN INFANTS WITH HYPOCHROMIC MICROCYTIC ANEMIA. ( 14162565 )
1964
15
Hereditary hypochromic microcytic anemia in obstetrics and gynecology. ( 14488836 )
1962
16
Glycine in hypochromic microcytic anemia. ( 13644763 )
1959
17
Hypochromic microcytic anemia of infancy; iron depletion as a factor. ( 13378924 )
1956
18
The pathogenesis of hypochromic microcytic anemia. ( 13163531 )
1954

Variations for Hypochromic Microcytic Anemia

Expression for Hypochromic Microcytic Anemia

Search GEO for disease gene expression data for Hypochromic Microcytic Anemia.

Pathways for Hypochromic Microcytic Anemia

Pathways related to Hypochromic Microcytic Anemia according to KEGG:

38
# Name Kegg Source Accession
1 Lysosome hsa04142
2 Mineral absorption hsa04978

GO Terms for Hypochromic Microcytic Anemia

Cellular components related to Hypochromic Microcytic Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.72 CP HBA1 HBA2 HBB TMPRSS6
2 blood microparticle GO:0072562 9.56 CP HBA1 HBA2 HBB
3 cytosolic small ribosomal subunit GO:0022627 9.37 HBA1 HBA2
4 endocytic vesicle lumen GO:0071682 9.33 HBA1 HBA2 HBB
5 hemoglobin complex GO:0005833 9.13 HBA1 HBA2 HBB
6 haptoglobin-hemoglobin complex GO:0031838 8.8 HBA1 HBA2 HBB

Biological processes related to Hypochromic Microcytic Anemia according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 receptor-mediated endocytosis GO:0006898 9.67 HBA1 HBA2 HBB
2 cellular oxidant detoxification GO:0098869 9.63 HBA1 HBA2 HBB
3 protein heterooligomerization GO:0051291 9.61 HBA1 HBA2 HBB
4 cellular iron ion homeostasis GO:0006879 9.58 CP SLC11A2 TMPRSS6
5 response to hydrogen peroxide GO:0042542 9.54 HBA1 HBA2 HBB
6 positive regulation of cell death GO:0010942 9.5 HBA1 HBA2 HBB
7 copper ion transport GO:0006825 9.48 CP SLC11A2
8 bicarbonate transport GO:0015701 9.43 HBA1 HBA2 HBB
9 iron ion homeostasis GO:0055072 9.33 SLC11A2 STEAP3 TMPRSS6
10 hydrogen peroxide catabolic process GO:0042744 9.13 HBA1 HBA2 HBB
11 oxygen transport GO:0015671 8.8 HBA1 HBA2 HBB

Molecular functions related to Hypochromic Microcytic Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.58 HBA1 HBA2 HBB
2 iron ion binding GO:0005506 9.54 HBA1 HBA2 SLC11A2
3 oxygen binding GO:0019825 9.5 HBA1 HBA2 HBB
4 copper ion binding GO:0005507 9.43 CP SLC11A2
5 peroxidase activity GO:0004601 9.43 HBA1 HBA2 HBB
6 oxygen carrier activity GO:0005344 9.33 HBA1 HBA2 HBB
7 organic acid binding GO:0043177 9.13 HBA1 HBA2 HBB
8 haptoglobin binding GO:0031720 8.8 HBA1 HBA2 HBB

Sources for Hypochromic Microcytic Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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