MCID: HYP001
MIFTS: 34

Hypochromic Microcytic Anemia

Categories: Blood diseases

Aliases & Classifications for Hypochromic Microcytic Anemia

MalaCards integrated aliases for Hypochromic Microcytic Anemia:

Name: Hypochromic Microcytic Anemia 12 37 29 13 15
Anemia, Hypochromic Microcytic 13 55
Microcytic Hypochromic Anemia 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050642
KEGG 37 H01196
UMLS 73 C0271901

Summaries for Hypochromic Microcytic Anemia

Disease Ontology : 12 A microcytic anemia characterized by paler than normal blood cells.

MalaCards based summary : Hypochromic Microcytic Anemia, also known as anemia, hypochromic microcytic, is related to hypochromic microcytic anemia with iron overload and hemosiderosis. An important gene associated with Hypochromic Microcytic Anemia is SLC11A2 (Solute Carrier Family 11 Member 2), and among its related pathways/superpathways are Lysosome and Mineral absorption. The drugs Iron and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and bone marrow, and related phenotype is liver/biliary system.

Related Diseases for Hypochromic Microcytic Anemia

Diseases related to Hypochromic Microcytic Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 hypochromic microcytic anemia with iron overload 34.5 SLC11A2 STEAP3
2 hemosiderosis 29.3 CP SLC11A2 TF
3 alpha-thalassemia 29.3 HBA2 HBB
4 iron deficiency anemia 29.3 SLC11A2 TF TMPRSS6
5 iron metabolism disease 29.1 CP SLC11A2 TF
6 atransferrinemia 29.1 CP SLC11A2 TF
7 thalassemia 28.8 HBA2 HBB TF
8 microcytic anemia 28.6 HBA2 SLC11A2 STEAP3 TF TMPRSS6
9 deficiency anemia 26.4 CP HBA2 HBB SLC11A2 TF TMPRSS6
10 iron-refractory iron deficiency anemia 11.9
11 anemia, hypochromic microcytic, with iron overload 1 11.7
12 anemia, hypochromic microcytic, with iron overload 2 11.5
13 fetal hemoglobin quantitative trait locus 1 11.2
14 anemia, sideroblastic, 1 11.2
15 anemia, sideroblastic, and spinocerebellar ataxia 11.2
16 majeed syndrome 11.2
17 celiac disease 1 10.1
18 hemoglobin zurich 10.0 HBA2 HBB
19 methemoglobinemia, beta-globin type 10.0 HBA2 HBB
20 glutathione peroxidase deficiency 9.9 HBA2 HBB
21 heinz body anemias 9.9 HBA2 HBB
22 rubeosis iridis 9.8 HBA2 HBB
23 sickle cell disease 9.8 HBA2 HBB
24 sickle cell anemia 9.7 HBA2 HBB
25 nutritional deficiency disease 9.7 TF TMPRSS6
26 ancylostomiasis 9.7 CP TF
27 epileptic encephalopathy, early infantile, 36 9.7 CP TF
28 eales disease 9.6 CP TF
29 protein-energy malnutrition 9.6 CP TF
30 siderosis 9.5 HBB TF
31 wilson disease 9.4 CP TF
32 metal metabolism disorder 9.4 CP SLC11A2 TF
33 immune system disease 9.2 HBB TF
34 hemoglobin h disease 9.0 HBA2 HBB TF
35 hemoglobinopathy 9.0 HBA2 HBB TF
36 congenital hemolytic anemia 9.0 HBA2 HBB TF
37 aceruloplasminemia 9.0 CP TF
38 beta-thalassemia 9.0 HBA2 HBB TF
39 hemochromatosis, type 1 8.1 CP HBB SLC11A2 TF TMPRSS6

Graphical network of the top 20 diseases related to Hypochromic Microcytic Anemia:



Diseases related to Hypochromic Microcytic Anemia

Symptoms & Phenotypes for Hypochromic Microcytic Anemia

MGI Mouse Phenotypes related to Hypochromic Microcytic Anemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 8.92 SLC11A2 STEAP3 TMPRSS6 CP

Drugs & Therapeutics for Hypochromic Microcytic Anemia

Drugs for Hypochromic Microcytic Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4 7439-89-6 23925
2 Anti-Infective Agents Phase 4
3 Lactoferrin Phase 4
4 Iron Supplement Nutraceutical Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Bovine Lactoferrin Versus Ferrous Sulphate In The Treatment Of Iron Deficiency Anemia During Pregnancy Recruiting NCT03202615 Phase 4 F (ferrous sulphate)
2 Detection of β Thalassemia Carriers by Red Cell Parameters Obtained From the H2 Automatic Counter Enrolling by invitation NCT00481221

Search NIH Clinical Center for Hypochromic Microcytic Anemia

Genetic Tests for Hypochromic Microcytic Anemia

Genetic tests related to Hypochromic Microcytic Anemia:

# Genetic test Affiliating Genes
1 Hypochromic Microcytic Anemia 29

Anatomical Context for Hypochromic Microcytic Anemia

MalaCards organs/tissues related to Hypochromic Microcytic Anemia:

41
Liver, Bone, Bone Marrow

Publications for Hypochromic Microcytic Anemia

Articles related to Hypochromic Microcytic Anemia:

(show all 18)
# Title Authors Year
1
Hereditary hypochromic microcytic anemia associated with loss-of-function DMT1 gene mutations and absence of liver iron overload. ( 29178181 )
2018
2
Evaluation of Alpha-Thalassemia Mutations in Cases with Hypochromic Microcytic Anemia: The A^stanbul Perspective. ( 26377141 )
2015
3
I+-Thalassemia frequency and mutations in children with hypochromic microcytic anemias and relation with I^-thalassemia, iron deficiency anemia. ( 22475300 )
2012
4
Hypochromic microcytic anemia with a variant hemoglobin. ( 19006231 )
2009
5
Severe hypochromic microcytic anemia in a patient with congenital atransferrinemia. ( 19579082 )
2009
6
hem6: an ENU-induced recessive hypochromic microcytic anemia mutation in the mouse. ( 18780836 )
2008
7
Hypochromic microcytic anemia as a clinical presentation of celiac disease. ( 16812948 )
2006
8
nm1054: a spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse. ( 15994289 )
2005
9
A 16-year-old girl with hypochromic microcytic anemia. ( 16253038 )
2005
10
Severe hypochromic microcytic anemia caused by a congenital defect of the iron transport pathway in erythroid cells. ( 15121718 )
2004
11
Ferrochelatase deficiency in the bone marrow in a syndrome of congenital hypochromic microcytic anemia, hyperferremia, and iron overload of the liver. ( 3856939 )
1985
12
Transferrin loss into the urine with hypochromic, microcytic anemia. ( 1246990 )
1976
13
Hereditary hypochromic microcytic anemia in the laboratory rat. ( 5958911 )
1966
14
MILK-INDUCED GASTROINTESTINAL BLEEDING IN INFANTS WITH HYPOCHROMIC MICROCYTIC ANEMIA. ( 14162565 )
1964
15
Hereditary hypochromic microcytic anemia in obstetrics and gynecology. ( 14488836 )
1962
16
Glycine in hypochromic microcytic anemia. ( 13644763 )
1959
17
Hypochromic microcytic anemia of infancy; iron depletion as a factor. ( 13378924 )
1956
18
The pathogenesis of hypochromic microcytic anemia. ( 13163531 )
1954

Variations for Hypochromic Microcytic Anemia

Expression for Hypochromic Microcytic Anemia

Search GEO for disease gene expression data for Hypochromic Microcytic Anemia.

Pathways for Hypochromic Microcytic Anemia

Pathways related to Hypochromic Microcytic Anemia according to KEGG:

37
# Name Kegg Source Accession
1 Lysosome hsa04142
2 Mineral absorption hsa04978

Pathways related to Hypochromic Microcytic Anemia according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.92 CP SLC11A2 STEAP3 TF
2 12.03 CP HBB SLC11A2
3
Show member pathways
11.9 CP SLC11A2 STEAP3 TF
4
Show member pathways
11.54 HBA2 HBB
5
Show member pathways
11.49 CP SLC11A2
6 11.29 CP TF
7 11.19 SLC11A2 STEAP3
8 11.14 SLC11A2 TF
9 11.09 HBA2 HBB
10 10.87 HBA2 HBB
11
Show member pathways
10.8 HBA2 HBB
12 10.53 CP SLC11A2 STEAP3 TF
13 10.21 SLC11A2 STEAP3 TF

GO Terms for Hypochromic Microcytic Anemia

Cellular components related to Hypochromic Microcytic Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 CP HBA2 HBB TF TMPRSS6
2 endosome membrane GO:0010008 9.54 SLC11A2 STEAP3 TF
3 endocytic vesicle lumen GO:0071682 9.32 HBA2 HBB
4 hemoglobin complex GO:0005833 9.26 HBA2 HBB
5 basal part of cell GO:0045178 9.16 SLC11A2 TF
6 haptoglobin-hemoglobin complex GO:0031838 8.96 HBA2 HBB
7 blood microparticle GO:0072562 8.92 CP HBA2 HBB TF

Biological processes related to Hypochromic Microcytic Anemia according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.71 CP SLC11A2 STEAP3 TF
2 cellular oxidant detoxification GO:0098869 9.52 HBA2 HBB
3 protein heterooligomerization GO:0051291 9.51 HBA2 HBB
4 response to hydrogen peroxide GO:0042542 9.49 HBA2 HBB
5 positive regulation of cell death GO:0010942 9.48 HBA2 HBB
6 bicarbonate transport GO:0015701 9.46 HBA2 HBB
7 transferrin transport GO:0033572 9.43 STEAP3 TF
8 hydrogen peroxide catabolic process GO:0042744 9.37 HBA2 HBB
9 iron ion transport GO:0006826 9.32 SLC11A2 TF
10 oxygen transport GO:0015671 9.26 HBA2 HBB
11 cellular iron ion homeostasis GO:0006879 9.26 CP SLC11A2 TF TMPRSS6
12 copper ion transport GO:0006825 9.16 CP SLC11A2
13 iron ion homeostasis GO:0055072 8.92 SLC11A2 STEAP3 TF TMPRSS6

Molecular functions related to Hypochromic Microcytic Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxygen binding GO:0019825 9.26 HBA2 HBB
2 peroxidase activity GO:0004601 9.16 HBA2 HBB
3 oxygen carrier activity GO:0005344 8.96 HBA2 HBB
4 haptoglobin binding GO:0031720 8.62 HBA2 HBB

Sources for Hypochromic Microcytic Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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