MCID: HYP001
MIFTS: 38

Hypochromic Microcytic Anemia

Categories: Blood diseases

Aliases & Classifications for Hypochromic Microcytic Anemia

MalaCards integrated aliases for Hypochromic Microcytic Anemia:

Name: Hypochromic Microcytic Anemia 12 37 29 15
Anemia, Hypochromic Microcytic 55
Microcytic Hypochromic Anemia 72

Classifications:



External Ids:

Disease Ontology 12 DOID:0050642
KEGG 37 H01196
UMLS 72 C0271901

Summaries for Hypochromic Microcytic Anemia

KEGG : 37
Hypochromic microcytic anemia has been associated with a defect of iron absorption due to reduced iron entry into intestinal cells. Several isoforms of NRAMP2 (SLC11A2) are expressed ubiquitously in recycling endosomes or specifically at the apical membrane of epithelial cells in intestine and kidneys, and can contribute to iron overload, whereas mutations impairing NRAMP2 function cause a form of congenital hypochromic microcytic anemia.

MalaCards based summary : Hypochromic Microcytic Anemia, also known as anemia, hypochromic microcytic, is related to hypochromic microcytic anemia with iron overload and iron metabolism disease. An important gene associated with Hypochromic Microcytic Anemia is SLC11A2 (Solute Carrier Family 11 Member 2), and among its related pathways/superpathways are Lysosome and Mineral absorption. The drugs Anti-Infective Agents and Iron Supplement have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and lymph node, and related phenotype is liver/biliary system.

Disease Ontology : 12 A microcytic anemia characterized by paler than normal blood cells.

Related Diseases for Hypochromic Microcytic Anemia

Diseases related to Hypochromic Microcytic Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 66, show less)
# Related Disease Score Top Affiliating Genes
1 hypochromic microcytic anemia with iron overload 34.9 STEAP3 SLC11A2
2 iron metabolism disease 31.2 SLC11A2 CP
3 iron deficiency anemia 30.9 TMPRSS6 SLC11A2
4 hemosiderosis 30.8 SLC11A2 CP
5 atransferrinemia 30.4 SLC11A2 CP
6 thalassemia 29.8 HBB HBA2 HBA1
7 microcytic anemia 29.8 TMPRSS6 STEAP3 SLC11A2 HBA2 HBA1
8 hemolytic anemia 29.3 HBB HBA2 HBA1
9 alpha-thalassemia 29.2 HBB HBA2 HBA1
10 deficiency anemia 29.2 TMPRSS6 SLC11A2 HBB HBA2 CP
11 beta-thalassemia 29.2 HBB HBA2 HBA1
12 iron-refractory iron deficiency anemia 12.2
13 anemia, hypochromic microcytic, with iron overload 1 11.9
14 anemia, hypochromic microcytic, with iron overload 2 11.8
15 fetal hemoglobin quantitative trait locus 1 11.8
16 anemia, sideroblastic, 1 11.5
17 anemia, sideroblastic, and spinocerebellar ataxia 11.5
18 majeed syndrome 11.5
19 protoporphyria, erythropoietic, 1 10.4
20 celiac disease 1 10.4
21 splenomegaly 10.4
22 rare hereditary hemochromatosis 10.4
23 colorectal cancer 10.2
24 autosomal recessive disease 10.2
25 colorectal adenoma 10.2
26 nephrotic syndrome 10.2
27 pica disease 10.2
28 male infertility 10.2
29 bilirubin metabolic disorder 10.2
30 glomerulonephritis 10.2
31 purpura 10.2
32 systemic scleroderma 10.2
33 uremia 10.2
34 proliferative glomerulonephritis 10.2
35 infertility 10.2
36 adenoma 10.2
37 chronic kidney disease 10.2
38 evans' syndrome 10.2
39 sideroblastic anemia 10.2
40 hematopoietic stem cell transplantation 10.2
41 metal metabolism disorder 10.1 SLC11A2 CP
42 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 10.0 HBA2 HBA1
43 diabetes mellitus, insulin-dependent, 24 10.0 HBA2 HBA1
44 hydrops fetalis, nonimmune 10.0 HBA2 HBA1
45 hydrops fetalis 10.0 HBA2 HBA1
46 hypoglycemic coma 10.0 HBA2 HBA1
47 erythrocytosis, familial, 7 10.0 HBA2 HBA1
48 type 1 diabetes mellitus 7 10.0 HBA2 HBA1
49 type 1 diabetes mellitus 11 9.9 HBA2 HBA1
50 immature cataract 9.9 HBA2 HBA1
51 nutritional deficiency disease 9.9 TMPRSS6 CP
52 hemochromatosis, type 1 9.8 TMPRSS6 SLC11A2 CP
53 retinal vascular disease 9.8 HBA2 HBA1
54 hemoglobin zurich 9.7 HBB HBA2
55 rubeosis iridis 9.6 HBB HBA2
56 glucose metabolism disease 9.6 HBA2 HBA1
57 sickle cell disease 9.5 HBB HBA2
58 congenital hemolytic anemia 9.4 HBB HBA2
59 methemoglobinemia, beta-globin type 9.3 HBB HBA2 HBA1
60 glutathione peroxidase deficiency 9.3 HBB HBA2 HBA1
61 heinz body anemias 9.3 HBB HBA2 HBA1
62 alpha thalassemia-intellectual disability syndrome type 1 9.3 HBB HBA2 HBA1
63 hemoglobin h disease 9.3 HBB HBA2 HBA1
64 hemoglobinopathy 9.3 HBB HBA2 HBA1
65 sickle cell anemia 9.2 HBB HBA2 HBA1
66 malaria 8.6 HBB HBA2 HBA1

Graphical network of the top 20 diseases related to Hypochromic Microcytic Anemia:



Diseases related to Hypochromic Microcytic Anemia

Symptoms & Phenotypes for Hypochromic Microcytic Anemia

MGI Mouse Phenotypes related to Hypochromic Microcytic Anemia:

46 (showing 1, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 8.92 CP SLC11A2 STEAP3 TMPRSS6

Drugs & Therapeutics for Hypochromic Microcytic Anemia

Drugs for Hypochromic Microcytic Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 10, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Infective Agents Phase 4
2 Iron Supplement Phase 4
3 Lactoferrin Phase 4
4
Iron Approved, Experimental 15438-31-0, 7439-89-6 23925 27284
5 Hematinics
6 Ferric Compounds
7 ferric gluconate
8 Nutrients
9 Micronutrients
10 Trace Elements

Interventional clinical trials:

(showing 6, show less)
# Name Status NCT ID Phase Drugs
1 Bovine Lactoferrin Versus Ferrous Sulphate In The Treatment Of Iron Deficiency Anemia During Pregnancy: A Randomized Controlled Trial Recruiting NCT03202615 Phase 4 F (ferrous sulphate)
2 Detection of β Thalassemia Carriers by Red Cell Parameters Obtained From the H2 Automatic Counter. A Clinical Retrospective Study. Unknown status NCT00481221
3 CONTROLLED RANDOMIZED PILOT STUDY TO COMPARE THE EFFICACY OF DIFFERENT IRON FORMULATIONS: SUCROSOMAL FERRIC PYROPHOSPHATE, SUNACTIVE Fe AND INTRAVENOUS FERRIC GLUCONATE Completed NCT03771092
4 New Versus Standard Enteral Iron Supplementation Regime in Very Low Birth Weight Infants - A Randomized Controlled Trial Completed NCT00683527 Elemental iron
5 Detection of β-thalassemia Carriers Among Close Relatives of β-thalassemia Children Attending Assiut University Children Hospital Not yet recruiting NCT03822585
6 Red Cell Distribution Width Index Versus Red Cell Distribution Width as Discriminating Guide for Iron Deficiency Anaemia and Beta Thalassemia Trait . Not yet recruiting NCT03868306

Search NIH Clinical Center for Hypochromic Microcytic Anemia

Genetic Tests for Hypochromic Microcytic Anemia

Genetic tests related to Hypochromic Microcytic Anemia:

# Genetic test Affiliating Genes
1 Hypochromic Microcytic Anemia 29

Anatomical Context for Hypochromic Microcytic Anemia

MalaCards organs/tissues related to Hypochromic Microcytic Anemia:

41
Kidney, Liver, Lymph Node, Heart, Bone, Small Intestine, Bone Marrow

Publications for Hypochromic Microcytic Anemia

Articles related to Hypochromic Microcytic Anemia:

(showing 460, show less)
# Title Authors PMID Year
1
Studies of a naturally occurring sulfur-induced copper deficiency in Przewalski's gazelles. 9 38
20190976 2009
2
Severe hypochromic microcytic anemia in a patient with congenital atransferrinemia. 9 38
19579082 2009
3
Two nonsense mutations in the TMPRSS6 gene in a patient with microcytic anemia and iron deficiency. 9 38
18596229 2008
4
Natural history of recessive inheritance of DMT1 mutations. 9 38
18154916 2008
5
Recent progress in structure-function analyses of Nramp proton-dependent metal-ion transporters. 9 38
17215883 2006
6
Two new human DMT1 gene mutations in a patient with microcytic anemia, low ferritinemia, and liver iron overload. 9 38
16439678 2006
7
Functional consequences of the human DMT1 (SLC11A2) mutation on protein expression and iron uptake. 9 38
16091455 2005
8
Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload. 9 38
15459009 2005
9
Recently identified molecular aspects of intestinal iron absorption. 9 38
9808632 1998
10
Non-iron mediated alteration in hepatic transferrin gene expression in the nephrotic rat. 9 38
7783403 1995
11
Thalassemia intermedia: compound heterozygous beta zero/beta(+)-thalassemia and co-inherited heterozygous alpha(+)-thalassemia. 9 38
8431522 1993
12
Congenital atransferrinemia. A case report and review of the literature. 9 38
1862777 1991
13
Presentation of Compound Heterozygous Hemoglobin Constant Spring and Hemoglobin Pakse in Neonates. 38
30615015 2019
14
Iron Refractory Iron Deficiency Anemia Due to 374 Base Pairs Deletion in the TMPRSS6 Gene. 38
30130276 2019
15
NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms. 38
30630985 2019
16
Clinical and therapeutic aspects of an outbreak of canine trypanosomiasis. 38
31188944 2019
17
Causes of Hypochromic Microcytic Anemia in Children and Evaluation of Laboratory Parameters in the Differentiation. 38
30557168 2019
18
Clinical Case of Parvovirus B19 Infection in Pregnant Woman with Β-Thalassemia in Bulgaria. 38
31115230 2019
19
An Incidental Finding of Anemia: Rectal Adenocarcinoma in a Young Adult. 38
31275778 2019
20
A case of ectopic pancreas in the ileum presenting as obscure gastrointestinal bleeding and abdominal pain. 38
30995913 2019
21
Reference intervals for HbA2 and HbF and cut-off value of HbA2 for β-thalassemia carrier screening in a Guizhou population of reproductive age. 38
30503531 2019
22
Distinguishing iron deficiency anemia from thalassemia by the red blood cell lifespan with a simple CO breath test: a pilot study. 38
30641506 2019
23
Recognizing missed opportunities to diagnose and treat iron deficiency anemia: A study based on prevalence of anemia among children in a teaching hospital. 38
31041221 2019
24
Neuronopathic Gaucher disease presenting with microcytic hypochromic anemia. 38
30456712 2019
25
Correction to: Neuronopathic Gaucher disease presenting with microcytic hypochromic anemia. 38
30632057 2019
26
Redundant and nonredundant organismal functions of EPS15 and EPS15L1. 38
30692166 2019
27
Hb Knossos (HBB: c.82G > T), β-globin CD 5 (-CT) (HBB: c.17_18delCT) and δ-globin CD 59 (-a) (HBD: c.179delA) mutations in a Syrian patient with β-thalassemia intermedia. 38
30777047 2019
28
Central retinal vein occlusion in a patient with breast carcinoma. 38
30828514 2019
29
First Report of Association Between Rare α-Thalassemia Mutation (HBA1: c.298A>T) and Hb Fontainebleau (HBA2: c.64G>C). 38
30728682 2019
30
Clinical manifestations of chronic atrophic gastritis. 38
30561424 2018
31
Molecular analysis of hemoglobinopathies in a large ethnic Hakka population in southern China. 38
30407298 2018
32
Systemic manifestations of extraskeletal myxoid chondrosarcoma associated with a novel t(2;22)(q34;q12) EWS translocation in a child and a review of the literature. 38
30776935 2018
33
Coinheritance of HbD-Punjab/β+-thalassemia (IVSI+5 G-C) in patient with Gilbert's syndrome. 38
30701931 2018
34
Awareness and Attitude of University Students About Screening and Testing for Hemoglobinopathies: Case Study of the Aseer Region, Saudi Arabia. 38
30821195 2018
35
Clinical Course of Homozygous Hemoglobin Constant Spring in Pediatric Patients. 38
29668548 2018
36
Molecular basis of α-thalassemia. 38
29032940 2018
37
Prevalence of anemia in schools of the metropolitan region of Curitiba, Brazil. 38
30057988 2018
38
Novel interactions of two α-Hb variants with SEA deletion α0-thalassemia: hematological and molecular analyses. 38
28945175 2018
39
Hereditary hypochromic microcytic anemia associated with loss-of-function DMT1 gene mutations and absence of liver iron overload. 38
29178181 2018
40
A rare case of signet-ring cell carcinoma associated with poorly differentiated adenocarcinoma of the non-ampullary duodenum. 38
29940643 2018
41
Hematological abnormalities in HIV-antiretroviral therapy naïve clients as seen at an immune suppression syndrome clinic at Mbarara Regional Referral Hospital, southwestern Uganda. 38
29983600 2018
42
Associations between iron deficiency anemia and clinical features among pregnant women: a prospective cohort study. 38
30323700 2018
43
Hepatocyte nuclear factor 1A deficiency causes hemolytic anemia in mice by altering erythrocyte sphingolipid homeostasis. 38
29109103 2017
44
Revisiting beta thalassemia intermedia: past, present, and future prospects. 38
28589785 2017
45
Widening the spectrum of deletions and molecular mechanisms underlying alpha-thalassemia. 38
28887661 2017
46
The Frequency and Importance of Common α-globin Gene Deletions Among β-Thalassemia Carriers in an Iranian Population. 38
29090069 2017
47
Rare Ileal Ewing Sarcoma/Primitive Neuroectodermal Tumor on 18F-FDG PET/CT. 38
28806254 2017
48
Diagnosis and molecular characterization of a novel α0 -thalassemia deletion (-Kozani) found in a Greek child with unexplained microcytic hypochromic anemia. 38
28603861 2017
49
A child with severe iron-deficiency anemia and a complex TMPRSS6 genotype. 38
28447549 2017
50
Congenital Hypotransferrinemia, an Unusual Cause of Iron Deficiency Anemia: Report of Two Cases. 38
28824244 2017
51
New Bioinformatics-Based Discrimination Formulas for Differentiation of Thalassemia Traits From Iron Deficiency Anemia. 38
28934514 2017
52
Extracellular glycine is necessary for optimal hemoglobinization of erythroid cells. 38
28495915 2017
53
Prevalence of Erythrocyte Changes in Patients with Heart Failure. 38
30595887 2017
54
Insight into donor deferral pattern based on peripheral blood counts: An experience from South Pakistan. 38
28970684 2017
55
Haematological and biochemical indicators of tropical theileriosis diseased cattle in wilaya of Sétif (North East Algeria). 38
28615875 2017
56
Prevalence of Thalassemia Traits and Iron Deficiency Anemia in Sindh, Pakistan. 38
28745572 2017
57
A Novel ALAS2 Mutation Resulting in Variable Phenotypes and Pyridoxine Response in a Family with X-linked Sideroblastic Anemia. 38
28667034 2017
58
Disturbed iron metabolism in erythropoietic protoporphyria and association of GDF15 and gender with disease severity. 38
28185024 2017
59
Differentiation of beta thalassemia trait from iron deficiency anemia by hematological indices. 38
28811791 2017
60
Can soluble transferrin receptor be used in diagnosing iron deficiency anemia and assessing iron response in infants with moderate acute malnutrition? 38
28318177 2017
61
Iron Refractory Iron Deficiency Anemia in Dizygotic Twins Due to a Novel TMPRSS6 Gene Mutation in Addition to Polymorphisms Associated With High Susceptibility to Develop Ferropenic Anemia. 38
28491880 2017
62
[THE LABORATORY MARKERS OF DETECTION OF BETA-THALASSEMIA CARRIAGE]. 38
30620522 2017
63
Evaluation of Applying a Combination of Red Cell Indexes and Formulas to Differentiate β-Thalassemia Trait from Iron Deficiency Anemia in the Thai Population. 38
28597705 2017
64
[Analysis of clinical phenotype and genotype of unstable Hemoglobin Rush]. 38
28186586 2017
65
Prevalence of Anemia and Hemoglobin Disorders Among School Children in Myanmar. 38
28367656 2017
66
Haematological evaluation of sodium fluoride toxicity in oryctolagus cunniculus. 38
28959673 2017
67
Plummer Vinson Syndrome: A Rare Syndrome in Male with Review of the Literature. 38
28932606 2017
68
Iron refractory iron deficiency anemia: a heterogeneous disease that is not always iron refractory. 38
27643674 2016
69
Prevalence and management of anemia in pre-dialysis Malaysian patients: A hospital-based study. 38
27992014 2016
70
Molecular analysis of complex cases of alpha- and beta-thalassemia in Mexican mestizo patients with microcytosis and hypochromia reveals two novel alpha(0) -thalassemia deletions - -(Mex1) and - -(Mex2). 38
27339814 2016
71
Hb Olivet (HBA1: C.40G > A; p.Ala14Thr), a Novel Silent Hemoglobin Variant in Two Families of Distinct Origin. 38
27624280 2016
72
HMGB1 Mediates Anemia of Inflammation in Murine Sepsis Survivors. 38
26736178 2016
73
Iron-refractory iron deficiency anemia (IRIDA) cases with 2 novel TMPRSS6 mutations. 38
27120435 2016
74
Multiple copy number variants in a pediatric patient with Hb H disease and intellectual disability. 38
26753516 2016
75
[Gene Analysis of Thalassemia in Han and Dai Ethnic Childbearing-aged Population of Chinese Yunnan Province]. 38
26913412 2016
76
Identification of Mutations Causing Aberrant Termination and Deficient Splice Donor Site on the HBA1 Gene. 38
26531168 2016
77
Resolution of constipation, anal stricture, and iron deficiency anemia after iron infusion: an analogy with Plummer Vinson syndrome. 38
27917348 2016
78
[Portal cavernoma in children revealed by gastrointestinal haemorrhage: about a case]. 38
28292120 2016
79
NCOA4 Deficiency Impairs Systemic Iron Homeostasis. 38
26776506 2016
80
Hemoglobin Agenogi--A rare abnormal beta globin chain variant. 38
26960650 2016
81
Evaluation of Alpha-Thalassemia Mutations in Cases with Hypochromic Microcytic Anemia: The İstanbul Perspective. 38
26377141 2015
82
Giant adrenal hemangioma: Unusual cause of huge abdominal mass. 38
26600897 2015
83
A Rare Haemoglobin Variant Identified as K Woolwich in a Pakistani Male. 38
26522187 2015
84
Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese. 38
26294671 2015
85
[Beta thalassemia intermedia: clinical characteristics and molecular analysis. Case series]. 38
26294166 2015
86
Compound heterozygosity for KLF1 mutations is associated with microcytic hypochromic anemia and increased fetal hemoglobin. 38
25585695 2015
87
How I Diagnose Non-thalassemic Microcytic Anemias. 38
26404439 2015
88
Hemato-biochemical and pathological changes on avian influenza in naturally infected domestic ducks in Egypt. 38
27047014 2015
89
[Rare gastroenterologic finding as a cause of hypochromic microcytic anemia]. 38
26445262 2015
90
[Genotypes and clinical features of 595 children with HbH disease in Guangxi, China]. 38
26412168 2015
91
Hematological and biochemical investigations on the effect of vitamin E and C on Oreochromis niloticus exposed to zinc oxide nanoparticles. 38
26288558 2015
92
Effects of Acute Exposure to Endosulfan (Organochlorine Pesticides) on Hematology of African Mud Catfish, Clarias gariepinus (Burchell, 1822). 38
25726008 2015
93
[Association between anemia and 3-year all-cause mortality among oldest old people in longevity areas in China]. 38
26564693 2015
94
Anemia in patients on chronic hemodialysis in Cameroon: prevalence, characteristics and management in low resources setting. 38
25834556 2015
95
Oral manifestations of plummer-vinson syndrome: a classic report with literature review. 38
25878483 2015
96
Iron-refractory iron deficiency anemia. 38
25805669 2015
97
Diagnosis and treatment of sideroblastic anemias: from defective heme synthesis to abnormal RNA splicing. 38
26637696 2015
98
Hepcidin in tumor-related iron deficiency anemia and tumor-related anemia of chronic disease: pathogenic mechanisms and diagnosis. 38
24954786 2015
99
Mutations on the α2-Globin Gene That May Trigger α(+)-Thalassemia. 38
26329872 2015
100
Presence of anti-mitochondrial antibodies and elevated serum immunoglobulin G levels: is this primary biliary cirrhosis-autoimmune hepatitis overlap syndrome? 38
26648811 2015
101
Multivitamin and iron supplementation to prevent periconceptional anemia in rural tanzanian women: a randomized, controlled trial. 38
25905863 2015
102
A 21 Nucleotide Duplication on the α1- and α2-Globin Genes Involves a Variety of Hypochromic Microcytic Anemias, From Mild to Hb H Disease. 38
25976776 2015
103
Nonsecretory multiple myeloma presenting as an intestinal tumor. 38
25960896 2015
104
Erythrocyte Catalase Activity in More Frequent Microcytic Hypochromic Anemia: Beta-Thalassemia Trait and Iron Deficiency Anemia. 38
26527217 2015
105
Reliability of Different RBC Indices and Formulas in Discriminating between β-Thalassemia Minor and other Microcytic Hypochromic Cases. 38
25745549 2015
106
The Molecular Basis of α-Thalassemia in the Qatari Pediatric Population. 38
26161810 2015
107
Anemia and iron deficiency among school adolescents: burden, severity, and determinant factors in southwest Ethiopia. 38
26719736 2015
108
Functional and clinical impact of novel TMPRSS6 variants in iron-refractory iron-deficiency anemia patients and genotype-phenotype studies. 38
25156943 2014
109
Aceruloplasminemia in a Turkish adolescent with a novel mutation of ceruloplasmin gene: the first diagnosed case from Turkey. 38
25247888 2014
110
Novel mutation in the TMPRSS6 gene with iron-refractory iron deficiency anemia. 38
25252070 2014
111
[Molecular diagnosis for a novel deletion mutation of α thalassemia]. 38
25152121 2014
112
[Identification and characterization of clinical features and gene mutation in a patient with iron refractory iron deficiency anemia (IRIDA)]. 38
24985168 2014
113
[Q fever - an occupational disease leading to disability - case report]. 38
25025682 2014
114
A case of plummer-vinson syndrome showing rapid improvement of Dysphagia and esophageal web after two weeks of iron therapy. 38
25028578 2014
115
Fitness for duty: two cases of rare hemoglobin variants in U.S. Navy recruits. 38
24594475 2014
116
Toxicological assessment of combined lead and cadmium: acute and sub-chronic toxicity study in rats. 38
24394482 2014
117
β-Thalassemia Intermedia: A Bird's-Eye View. 38
24764724 2014
118
[Congenital sideroblastic anemia-a new family with identification of K156E mutation of ALAS2 gene and literature review]. 38
24606657 2014
119
Characterizing a cohort of α-thalassemia couples collected during screening for hemoglobinopathies: 14 years of an Iranian experience. 38
24826790 2014
120
The physiological functions of iron regulatory proteins in iron homeostasis - an update. 38
24982634 2014
121
The multicopper ferroxidase hephaestin enhances intestinal iron absorption in mice. 38
24896847 2014
122
Anemia among hospitalized children at a multispecialty hospital, bangalore (karnataka), India. 38
24791237 2014
123
Efficiency of recombinant erythropoietin administration in hemoglobinopathy H. 38
24523332 2014
124
Coexistence of two β-globin gene deletions in a Chinese girl with β-thalassemia minor. 38
24200214 2014
125
Homozygosity for HBA1: c.179G > A: Hb Adana in an infant. 38
25342395 2014
126
DMT1-mutant erythrocytes have shortened life span, accelerated glycolysis and increased oxidative stress. 38
25562168 2014
127
Is the acronym IRIDA acceptable for slow responders to iron in the presence of TMPRSS6 mutations? 38
24382527 2013
128
Adenocarcinoma of the ileocolic junction and multifocal hepatic sarcomas in an aged rhesus macaque (Macaca mulatta). 38
24209973 2013
129
Iron refractory iron deficiency anemia. 38
23729726 2013
130
[The prevalence and characteristics of anemia in Crohn's disease in the Chinese]. 38
23945299 2013
131
[Analysis of clinical phenotypes of compound heterozygotes of Hb J-Bangkok and β-thalassemia]. 38
23568723 2013
132
Early diagnosis of co-existent ß-thalassemia and alkaptonuria. 38
24019631 2013
133
Microcytic hypochromic anemia: should high performance liquid chromatography be used routinely for screening anemic and antenatal patients? 38
24056645 2013
134
A case of extraovarian primary peritoneal carcinoma in an oophorectomized-hysterectomized patient: a diagnostic dilemma. 38
23578412 2013
135
Insights into the pathophysiology of iron metabolism in Pythium insidiosum infections. 38
23182911 2013
136
Iron refractory iron deficiency anemia: presentation with hyperferritinemia and response to oral iron therapy. 38
23319530 2013
137
ENU mutagenesis identifies the first mouse mutants reproducing human β-thalassemia at the genomic level. 38
23040355 2013
138
CNTO 530 increases expression of HbA and HbF in murine models of β-thalassemia and sickle cell anemia. 38
23157711 2013
139
[Hookworm as cause of iron deficiency anemia in the prison population]. 38
23843143 2013
140
Micronutrient deficiencies in obese Thai children. 38
23945419 2013
141
Novel mutations responsible for α-thalassemia in Iranian families. 38
23402770 2013
142
A case with mega cisterna magna renal and ear anomalies: is this a new syndrome? 38
23762068 2013
143
Association of Hb Thailand [α56(E5)Lys→Thr] and Hb Phnom Penh [α117(GH5)-Ile-α118(H1)] with α(0)-thalassemia: molecular and hematological features and differential diagnosis. 38
23215800 2013
144
Identification of the first mutation in a BRE motif of the β-globin gene and its inheritance with two other α-globin gene mutations in a Lebanese family. 38
23470150 2013
145
Premarital Screening of Beta Thalassemia Minor in north-east of Iran. 38
24575266 2013
146
Hematopoietic protein-1 regulates the actin membrane skeleton and membrane stability in murine erythrocytes. 38
23424621 2013
147
A Rare Presentation of Ménétrier's Disease as Gastroduodenal Intussusception. 38
24829671 2013
148
Pruritic vesicular eruption on the lower legs in a diabetic female. 38
24194986 2013
149
Iron deficiency anemia in captive āalayan tapir calves (Tapirus indicus). 38
23272357 2012
150
Reticulocyte hemoglobin equivalent to detect thalassemia and thalassemic hemoglobin variants. 38
22765164 2012
151
Erythropoietin-driven signaling ameliorates the survival defect of DMT1-mutant erythroid progenitors and erythroblasts. 38
22580996 2012
152
Castleman disease in a child with short stature. 38
23005908 2012
153
Bilateral Mooren's ulcer in a child secondary to helminthic infestation of the gastrointestinal tract. 38
22661075 2012
154
Molecular mechanisms of hookworm disease: stealth, virulence, and vaccines. 38
22742835 2012
155
Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2. 38
22460705 2012
156
Total allowable concentrations of monomeric inorganic aluminum and hydrated aluminum silicates in drinking water. 38
22512666 2012
157
A novel mutation Gly603Arg of TMPRSS6 in a Korean female with iron-refractory iron deficiency anemia. 38
21618415 2012
158
A new unstable hemoglobin variant Hb Acharnes or [β53(D4) Ala - Thr]: a case report. 38
22561788 2012
159
A novel α(0) -thalassemia deletion in a Greek patient with HbH disease and β-thalassemia trait. 38
22324317 2012
160
Essential thrombocytosis and antiphospholipid antibody syndrome causing chronic Budd-Chiari syndrome. 38
21830019 2012
161
[Diagnosis of hypochromic microcytic anemia in children]. 38
22310020 2012
162
Responsiveness to oral iron and ascorbic acid in a patient with IRIDA. 38
22169218 2012
163
Hb H disease with various β hemoglobinopathies: molecular, hematological and diagnostic aspects. 38
22145566 2012
164
A new ATRX mutation in a patient with acquired α-thalassemia myelodysplastic syndrome. 38
23092150 2012
165
Importance of sideropenic anemia in the diagnosis of gastrointestinal tract tumors. 38
23922517 2012
166
H(+)-coupled divalent metal-ion transporter-1: functional properties, physiological roles and therapeutics. 38
23177986 2012
167
Hb Iberia [α104(G11)Cys → Arg,TGC>CGC (α2) (HBA2:c.313T>C)], a new α-thalassemic hemoglobin variant found in the Iberian Peninsula: report of six cases. 38
23181747 2012
168
α-Thalassemia mutations in two provinces of Southern Iran: Fars & Kohkeloye and Bouyer Ahmad. 38
22401170 2012
169
Hematological, biochemical, and behavioral responses of Oncorhynchus mykiss to dimethoate. 38
21547568 2011
170
Mutation of the gastric hydrogen-potassium ATPase alpha subunit causes iron-deficiency anemia in mice. 38
21976678 2011
171
Hereditary hyperferritinemia-cataract syndrome (HHCS) presenting with iron deficiency anemia associated with a new mutation in the iron responsive element of the L ferritin gene in a Swiss family. 38
21410535 2011
172
Novel missense mutation in the TMPRSS6 gene in a Japanese female with iron-refractory iron deficiency anemia. 38
21643693 2011
173
[Molecular characterization of two new mutations of α° thalassemia in two Spanish families (mutation --(ED) and --(GP))]. 38
21453942 2011
174
Molecular characterization of a discrete hemoglobinopathy upon investigation for a lung hydatic cyst in an old Tunisian patient. 38
21659055 2011
175
Inflammatory myofibroblastic tumor causing unexplained anemia in a toddler: a case report. 38
21329496 2011
176
Idiopathic pulmonary hemosiderosis: alveoli are an answer to anemia. 38
21206122 2011
177
AIDS Cholangiopathy in an Asymptomatic, Previously Undiagnosed Late-Stage HIV-Positive Patient from Kenya. 38
21994858 2011
178
Iron deficiency thrombocytopenia: a case report. 38
21757942 2011
179
Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis. 38
20959604 2011
180
Congenital erythropoietic porphyria: characterization of murine models of the severe common (C73R/C73R) and later-onset genotypes. 38
21365124 2011
181
Primary infertility as a rare presentation of celiac disease. 38
20537625 2010
182
Chordoid meningioma: a clinicopathologic study of 11 cases at a single institution. 38
20454999 2010
183
Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin. 38
20837779 2010
184
Congenital sideroblastic anemia treated as thalassemia major. 38
20956913 2010
185
HbQ-India associated with microcytosis: An uncommon hemoglobin variant associated with a common hematologic condition. 38
27263606 2010
186
[Minor beta thalassemia masked by a hemoglobin A2 mutant]. 38
20812185 2010
187
A new alpha(0)-thalassemia deletion found in a Dutch family (--(AW)). 38
20682466 2010
188
Iron deficiency anemia - a rare etiology of sinus thrombosis in adults. 38
20714964 2010
189
[Cameron lesion: an unusual cause of anemia]. 38
21186559 2010
190
Trichotillomania, recurrent trichobezoar and Rapunzel syndrome: case report and literature review. 38
20642912 2010
191
Reliability of red blood cell indices and formulas to discriminate between beta thalassemia trait and iron deficiency in children. 38
20423571 2010
192
["Endoscopy in a stone quarry"--multiple pigment stones 6 weeks after delivery]. 38
20221994 2010
193
Lead encephalopathy in an infant mimicking a neurometabolic disorder. 38
19633332 2010
194
Codon 24 (TAT>TAG) and codon 32 (ATG>AGG) (Hb Rotterdam): two novel alpha2 gene mutations associated with mild alpha-thalassemia found in the same family after newborn screening. 38
20642333 2010
195
Long-term intake of a high zinc diet causes iron deficiency anemia accompanied by reticulocytosis and extra-medullary erythropoiesis. 38
19651194 2009
196
Lead toxicity resulting from chronic ingestion of opium. 38
20046241 2009
197
Pregnancy in beta-thalassemia trait carriers: an uneventful journey. 38
19843388 2009
198
Not all DMT1 mutations lead to iron overload. 38
19553145 2009
199
An interesting case of pachydermoperiostosis with idiopathic myelofibrosis associated with monosomy 22. 38
19659869 2009
200
A differential diagnosis of microcytic hypochromic anemia for high-risk patients. 38
19570166 2009
201
[Esophagogastric variceal bleeding in a case of liver cirrhosis associated with thalassemia]. 38
19498311 2009
202
Hexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice after chronic oral exposure. 38
19479012 2009
203
Molecular spectrum of alpha-thalassemia mutations in microcytic hypochromic anemia patients from Saudi Arabia. 38
19371220 2009
204
Red cell distribution width (RDW) in the diagnosis of iron deficiency with microcytic hypochromic anemia. 38
19205647 2009
205
Microcytic hypochromic anemia patients with thalassemia: genotyping approach. 38
19359777 2009
206
Hyporesponsiveness to erythropoietin: causes and management. 38
19233068 2009
207
Molecular basis of inherited microcytic anemia due to defects in iron acquisition or heme synthesis. 38
19181781 2009
208
Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism. 38
18955558 2009
209
A novel polymorphism causes a different restriction pattern by RsaI in the beta-globin gene cluster: application in prenatal diagnosis. 38
19958186 2009
210
Complex interaction of Hb E [beta26(B8)Glu-->Lys], Hb Korle-Bu [beta73(E17)Asp-->Asn] and a deletional alpha-thalassemia-1 in pregnancy. 38
19958198 2009
211
Hypochromic microcytic anemia with a variant hemoglobin. 38
19006231 2009
212
Tubulointerstitial nephritis as an extraintestinal manifestation of Crohn's disease. 38
18838984 2008
213
Fever of unclear origin and cytopenia because of acute splenic sequestration in a young immunocompetent carrier of beta-globin mutation for Hb Valletta. 38
19092326 2008
214
hem6: an ENU-induced recessive hypochromic microcytic anemia mutation in the mouse. 38
18780836 2008
215
Renal tubular dysfunction with nephrocalcinosis in a patient with beta thalassemia minor. 38
18974585 2008
216
[Multicentric inflammatory pseudotumor with asynchronic presentation in meninges, liver, spleen and lymph nodes in a patient with seronegative spondiloarthropathy. Case report and review of the literature]. 38
18985595 2008
217
Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression. 38
18552213 2008
218
Majeed Syndrome 38
20301735 2008
219
Effects of everolimus monotherapy on hematological parameters and iron homeostasis in de novo liver transplant recipients: preliminary results. 38
18675097 2008
220
Toxicology and carcinogenesis studies of sodium dichromate dihydrate (Cas No. 7789-12-0) in F344/N rats and B6C3F1 mice (drinking water studies). 38
18716633 2008
221
Iron deficiency causes duodenum mucosal hyperplasia in male Wistar rats. 38
18358645 2008
222
Systemic lupus erythematosus in the Fars Province of Iran. 38
18372364 2008
223
Myelodysplasia and anemia of chronic disease in human tumor necrosis factor-alpha transgenic mice. 38
18205195 2008
224
Celiac disease in children with short stature. 38
18334792 2008
225
Chordoid meningioma arising in the pineal region: a case report. 38
18987835 2008
226
Refinement of the genetic cause of ATR-16. 38
17598130 2007
227
Case report of HbC/beta(0)-thalassemia from India. 38
17824920 2007
228
Hemoglobin H disease induced by the common SEA deletion and the rare hemoglobin Quong Sze in a Thai female: longitudinal clinical course, molecular characterization, and development of a PCR/RFLP-based detection method. 38
17503046 2007
229
Lower abdominal inflammatory myofibroblastic tumor -an unusual presentation- a case report and brief literature review. 38
17109166 2007
230
Giant basal cell carcinoma. 38
17618177 2007
231
Celiac disease as a rare cause of primary amenorrhea: a case report. 38
17583254 2007
232
Cranial neuroimaging in infantile tremor syndrome (ITS). 38
17413198 2007
233
Congenital erythropoietic porphyria due to a mutation in GATA1: the first trans-acting mutation causative for a human porphyria. 38
17148589 2007
234
[Primary gastric lymphoma complicating HIV infection]. 38
17506276 2007
235
Increased plasma transferrin, altered body iron distribution, and microcytic hypochromic anemia in ferrochelatase-deficient mice. 38
17003376 2007
236
A case of early diagnosed carnitine deficiency presenting with respiratory symptoms. 38
17726310 2007
237
Innovative parameters RET-Y, sTfR, and sTfR-F index in patients with microcytic, hypochromic anemia--their special value for hemoglobinopathies. 38
17573284 2007
238
NTP toxicity studies of sodium dichromate dihydrate (CAS No. 7789-12-0) administered in drinking water to male and female F344/N rats and B6C3F1 mice and male BALB/c and am3-C57BL/6 mice. 38
17342194 2007
239
Ulcus cruris associated with prolidase deficiency. 38
17459310 2006
240
Copper deficiency in yaks on pasture in western China. 38
17017658 2006
241
Severe anemia owing to occult pulmonary hemorrhage: a diagnostic pitfall. 38
16825995 2006
242
The "sugar" clear cell tumor of the lung-clinical presentation and diagnostic difficulties of an unusual lung tumor in youth. 38
16769325 2006
243
The anemia of "haemoglobin-deficit" (hbd/hbd) mice is caused by a defect in transferrin cycling. 38
16647565 2006
244
[A young child with acute abdomen and iron deficiency anemia]. 38
16774051 2006
245
Hematologic risk factors for stroke in Saudi children. 38
16532128 2006
246
[Hematological and clinical profile in sickle cell or thalassemic patients]. 38
16827261 2006
247
Genotyping of alpha-thalassemia in microcytic hypochromic anemia patients from North India. 38
17132905 2006
248
A "hidden treasure" causing microcytic hypochromic anemia. 38
16377336 2006
249
Prevalence of beta-thalassemia trait in premarital screening in Al-Hassa, Saudi Arabia. 38
16521869 2006
250
[Hemoglobinopathies--clinical symptoms and diagnosis of thalassemia and abnormal hemoglobins]. 38
16450733 2006
251
Hypochromic microcytic anemia as a clinical presentation of celiac disease. 38
16812948 2006
252
Iron metabolism mutant hbd mice have a deletion in Sec15l1, which has homology to a yeast gene for vesicle docking. 38
16289749 2005
253
Recombinant expression and functional characterization of human hephaestin: a multicopper oxidase with ferroxidase activity. 38
16274220 2005
254
A novel 5' ATRX mutation with splicing consequences in acquired alpha thalassemia-myelodysplastic syndrome. 38
16266892 2005
255
Clinical phenotypes and molecular diagnosis in a hitherto interaction of Hb E/beta thalassemia syndrome (beta(E)/beta(-31), (A -->G)). 38
16856429 2005
256
Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. 38
16227996 2005
257
nm1054: a spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse. 38
15994289 2005
258
A 16-year-old girl with hypochromic microcytic anemia. 38
16253038 2005
259
Lead toxicity update. A brief review. 38
16192916 2005
260
Paraneoplastic hypereosinophilia in a dog with intestinal T-cell lymphoma. 38
16134075 2005
261
[Therapy-resistant microcytic hypochromic anemia from malabsorption-related vitamin B6 deficiency after a gastrointestinal operation]. 38
16440762 2005
262
Anemia and iron status of Malay women attending an antenatal clinic in Kubang Kerian, Kelantan, Malaysia. 38
16438162 2005
263
Human fascioliasis and anaemia in Dakahlia Governorate, Egypt. 38
16083056 2005
264
Hephaestin--a ferroxidase of cellular iron export. 38
15778082 2005
265
[What is your diagnosis? Hypochromic microcytic anemia with Evans syndrome or autoimmune thrombocytopenic purpura?]. 38
16061453 2005
266
Transport of divalent transition-metal ions is lost in small-intestinal tissue of b/b Belgrade rats. 38
15736955 2005
267
Alpha-2-globin gene polyadenylation (AATAAA-->AATAAG) mutation in hemoglobin H disease among Kuwaitis. 38
16103716 2005
268
Adult onset of a Thalassemia intermedia genotype in association with a -alpha-3.7 homozygosity. Hb G-Accra [beta73(e17)Asp-->Asn] in combination with beta- and alpha-thalassemia in the same family. 38
16370487 2005
269
Molecular basis of Hb H disease in southwest Iran. 38
15768554 2005
270
Hb Amsterdam [alpha32(B13)Met--Ile (alpha2)]: a new unstable variant associated with an alpha-thalassemia phenotype and a new African polymorphism. 38
16370485 2005
271
Effect of vitamin A supplementation on hematopoiesis in children with anemia. 38
23105500 2005
272
ATR-16 due to a de novo complex rearrangement of chromosome 16. 38
15921166 2005
273
Anemia of chronic disease: pathophysiology and laboratory diagnosis. 38
15790548 2005
274
Thalassemia intermedia associated with complex interaction of Hb Beijing [alpha16(A14)Lys-->Asn] and Hb E [beta26(B8)Glu-->Lys] with a deletional alpha-thalassemia-1 in a Thai family. 38
15768559 2005
275
The chianti zebrafish mutant provides a model for erythroid-specific disruption of transferrin receptor 1. 38
15563524 2004
276
Anemia and impaired stress-induced erythropoiesis in aceruloplasminemic mice. 38
15528156 2004
277
Molecular spectrum of beta-thalassemia in the Mexican population. 38
15315794 2004
278
An alpha-thalassemia phenotype in a Dutch Hindustani, caused by a new point mutation that creates an alternative splice donor site in the first exon of the alpha2-globin gene. 38
15481895 2004
279
Hb Suan-Dok [alpha109(G16)Leu-->Arg; CTG-->CGG (alpha2)] described in a patient of African ancestry. 38
15481883 2004
280
Severe hypochromic microcytic anemia caused by a congenital defect of the iron transport pathway in erythroid cells. 38
15121718 2004
281
Disruption of ferroportin 1 regulation causes dynamic alterations in iron homeostasis and erythropoiesis in polycythaemia mice. 38
15084469 2004
282
Hb Dhonburi (Neapolis) [beta126(H4)Val-->Gly] identified in a family from northern Iran. 38
15658193 2004
283
Spirocercosis-associated esophageal sarcomas in dogs. A retrospective study of 17 cases (1997-2003). 38
14746980 2004
284
Treatment of iron deficiency anemia with Ferro-Folgamma. 38
15529613 2004
285
[Homozygous hemoglobin-E (Hb-EE) disease]. 38
15529816 2004
286
Iron supplementation in children with celiac disease. 38
14719782 2003
287
Evaluation of irregular menses in perimenarcheal girls: a pilot study. 38
14642958 2003
288
Iron handling and gene expression of the divalent metal transporter, DMT1, in the kidney of the anemic Belgrade (b) rat. 38
14531808 2003
289
Malignant tumors of the small intestine. 38
14564183 2003
290
Iron deficiency and erythropoiesis: new diagnostic approaches. 38
14500582 2003
291
alpha-globin gene deletion and point mutation analysis among in Iranian patients with microcytic hypochromic anemia. 38
14555321 2003
292
Tired blood. Part 2. 38
14595997 2003
293
Modulatory influence of tin-protoporphyrin on gossypol-induced alterations of heme oxygenase activity in male Wistar rats. 38
14527098 2003
294
Clinical and nutritional profile of children with celiac disease. 38
12736407 2003
295
Soluble transferrin receptor and immature reticulocytes are not useful for distinguishing iron-deficiency anemia from heterozygous beta-thalassemia. 38
12870058 2003
296
Characterization of embryonic globin genes of the zebrafish. 38
12618133 2003
297
Simultaneous congenital and acquired extrahepatic portosystemic shunts in two dogs. 38
12620048 2003
298
Safety and pharmacokinetics of oral lansoprazole in preadolescent rats exposed from weaning through sexual maturity. 38
12507665 2003
299
The zebrafish mutant gene chardonnay (cdy) encodes divalent metal transporter 1 (DMT1). 38
12393445 2002
300
A controlled, prospective screening study of celiac disease presenting as iron deficiency anemia. 38
12192198 2002
301
Abnormal NK cell lymphocytosis detected after splenectomy: association with repeated infections, relapsing neutropenia, and persistent polyclonal B-cell proliferation. 38
12095147 2002
302
[Recurrent lower gastro-intestinal bleeding in a 38-year-old patient]. 38
12085307 2002
303
Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. 38
11930010 2002
304
Multiple mechanisms for hereditary sideroblastic anemia. 38
11929048 2002
305
Iatrogenic copper deficiency associated with long-term copper chelation for treatment of copper storage disease in a Bedlington Terrier. 38
11393371 2001
306
Diagnosis of concurrent hemoglobin H disease and heterozygous beta-thalassemia. 38
11325652 2001
307
Chordoid meningioma with polyclonal gammopathy. Case report. 38
11147880 2001
308
Mammalian toxicity of 1,3-dichloropropene. 38
12882226 2001
309
Spontaneous intestinal adenocarcinoma in geriatric macaques (Macaca sp.). 38
11099139 2000
310
Watermelon stomach following and preceding systemic sclerosis. 38
11071584 2000
311
Beta-Thalassemia 38
20301599 2000
312
Treatment of primary defective iron-reutilization syndrome: revisited. 38
10985370 2000
313
[Hypochromic microcytic anemia as the only manifestation of celiac disease]. 38
11464599 2000
314
Subchronic and chronic toxicity of ingested 1,3-dichloropropene in dogs. 38
10620473 1999
315
Differential effects of orally versus parenterally administered qinghaosu derivative artemether in dogs. 38
10661809 1999
316
Chloramphenicol-induced mitochondrial dysfunction is associated with decreased transferrin receptor expression and ferritin synthesis in K562 cells and is unrelated to IRE-IRP interactions. 38
10430173 1999
317
[X-linked sideroblastic anemia]. 38
10483144 1999
318
[Hereditary hemoglobin H disease in Japanese siblings diagnosed by human parvovirus B19 infection]. 38
10483135 1999
319
Parasitic infections. Treatment and developmental therapeutics. 1. Necatoriasis. 38
10438896 1999
320
Radiographic, histologic, and cytologic lesions associated with mutations in the fitness1(4226SB) locus of mice. 38
10403440 1999
321
Non-transferrin-bound iron uptake in Belgrade and normal rat erythroid cells. 38
9989781 1999
322
Evidence for and consequences of chronic heme deficiency in Belgrade rat reticulocytes. 38
10082971 1999
323
Long-term clinical course of patients with idiopathic pulmonary hemosiderosis (1979-1994): prolonged survival with low-dose corticosteroid therapy. 38
10213256 1999
324
Prevalence of anemia in Japanese adolescents: 30 years' experience in screening for anemia. 38
10071454 1999
325
[Unusual case of disseminated sarcoidosis with prominent gastrointestinal symptoms]. 38
9987484 1999
326
Myelodysplastic syndrome with sideroblastic differentiation in a dog. 38
12075526 1999
327
An alpha-thalassemic hemoglobinopathy: homozygosity for the HB Agrinio alpha 2-globin chain variant. 38
9629496 1998
328
Chordoid meningioma in a child. Case report. 38
9452243 1998
329
Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. 38
9448300 1998
330
Extensive iatrogenic adenomyosis after laparoscopic myomectomy. 38
9457951 1998
331
[Basic principles and clinical significance of iron deficiency]. 38
9480250 1997
332
[Hereditary nonpolyposis colonic carcinoma with primary extra-colic manifestation]. 38
9381087 1997
333
[Generalized weakness in pre-existing achalasia]. 38
9324724 1997
334
Prevention of thrombocytopenia by thrombopoietin in myelosuppressed rhesus monkeys accompanied by prominent erythropoietic stimulation and iron depletion. 38
9207438 1997
335
Castleman's disease: a case report. 38
9260374 1997
336
Iron supplementation moderates but does not cure the Belgrade anemia. 38
9210290 1997
337
Molecular basis of asymptomatic beta-thalassemia major in an African American individual. 38
9056561 1997
338
A novel neurological disorder with progressive CNS calcification, deafness, renal tubular acidosis, and microcytic anemia. 38
9112970 1997
339
Compound heterozygosity for Hb Lepore-Boston and Hb Neapolis (Dhonburi) [beta 126(H4)Val-->Gly] in a patient from Naples, Italy. 38
9028819 1997
340
Celiac disease in Arabs. 38
8956178 1996
341
Defective iron uptake by the duodenum of Belgrade rats fed diets of different iron contents. 38
8967495 1996
342
Elevated levels of tumor necrosis factor-beta, gamma-interferon, and IL-6 mRNA in Castleman's disease. 38
7494511 1996
343
A novel (delta beta)(0)-thalassemia due to a approximately 30-kb deletion observed in a Turkish family. 38
8922490 1996
344
Hematopoietic stem cells in the hereditarily anemic Belgrade laboratory (b/b) rat. 38
7556533 1995
345
Late-onset X-linked sideroblastic anemia. Missense mutations in the erythroid delta-aminolevulinate synthase (ALAS2) gene in two pyridoxine-responsive patients initially diagnosed with acquired refractory anemia and ringed sideroblasts. 38
7560104 1995
346
Aluminum content of infant formulas used in Turkey. 38
8546886 1995
347
A new mutation of the ALAS2 gene in a large family with X-linked sideroblastic anemia. 38
7705839 1995
348
Primary Hodgkin's disease of the bone. 38
7530802 1995
349
Development of iron deficiency anemia in infant rhesus macaques. 38
7752609 1995
350
Microcytic anemia in mk/mk mice is not corrected by retroviral-mediated gene transfer of wild-type p45 NF-E2. 38
7995373 1995
351
Microcytic hypochromic anemia in idiopathic pulmonary hemosiderosis: a diagnostic pitfall. 38
7883371 1994
352
[Parvovirus B19-induced aplastic crisis in a patient with iron deficiency anemia]. 38
8065019 1994
353
The relationship between high maternal aluminum ingestion and anemia-related hematologic changes in rats. 38
24351201 1994
354
Heme oxygenase induction. A possible factor in aluminum-associated anemia. 38
7511925 1994
355
Inflammatory myofibroblastic tumor in children. 38
8364883 1993
356
[Aluminum contamination of pediatric parenteral nutrition solutions]. 38
8011795 1993
357
Beta-thalassemia unlinked to the beta-globin gene in an English family. 38
8101733 1993
358
[Anemias due to disorder of folate, vitamin B12 and transcobalamin metabolism]. 38
8235383 1993
359
Iron distribution in Belgrade rat reticulocytes after inhibition of heme synthesis with succinylacetone. 38
8507877 1993
360
[Transient pure red cell aplasia in an adult with acute parvovirus B19 infection: observation of PVB19 DNA by polymerase chain reaction, viral antibody and erythroid cells in the bone marrow]. 38
8510337 1993
361
Ovariectomy enhances cadmium-induced nephrotoxicity and hepatotoxicity in rats. 38
8480335 1993
362
Effects of cadmium on erythrocytic parameters. 38
12669284 1993
363
Treatment with gallium nitrate: evidence for interference with iron metabolism in vivo. 38
1337663 1992
364
Iron metabolism is modified by the copper status of a human erythroleukemic (K562) cell line. 38
1508944 1992
365
New observations in a child with angiofollicular lymph node hyperplasia (Castleman's disease) originated from the mesenteric root. 38
1510196 1992
366
[Secondary sideroblastic anemia caused by long term administration of anti-tuberculous agents including isoniazid]. 38
1507421 1992
367
[A case of ceruloplasmin deficiency which showed dementia, ataxia and iron deposition in the brain]. 38
1458725 1992
368
[Acquired hemoglobin H disease in the early stage of erythroleukemia]. 38
1312251 1992
369
[Iron-deficiency anemia: diagnosis and therapy]. 38
1566014 1992
370
[Clinical evaluation of anemia in the aged]. 38
1545920 1992
371
[Hematologic changes in rats treated with high doses of vitamin K3 (menadione)]. 38
1824515 1991
372
Aluminum uptake and toxicity in cultured mouse hepatocytes. 38
1912392 1991
373
Determining the cause of anemia. General approach, with emphasis on microcytic hypochromic anemias. 38
2020645 1991
374
Parasitic diseases. Other roundworms. Trichuris, hookworm, and Strongyloides. 38
2011642 1991
375
[Parasitologic, clinical, hematologic and serologic findings in puppies after lactogenic infection with Ancylostoma caninum ERCOLANI 1859 (Ancylostomidae)]. 38
1853668 1991
376
Ferric-salicylaldehyde isonicotinoyl hydrazone, a synthetic iron chelate, alleviates defective iron utilization by reticulocytes of the Belgrade rat. 38
2022700 1991
377
Abnormal megakaryocytopoiesis in the Belgrade laboratory rat. 38
1991162 1991
378
Maintenance of normal platelet mass in anemic Belgrade rats and their response to iron. 38
2397752 1990
379
[Medical treatment of uterine leiomyomatosis with an agonist of pituitary gonadotropins (GnRH). Presentation of a case]. 38
2125961 1990
380
[Iron deficiency and pregnancy. A survey in a Mother and Child Care Center in Niamey (Niger)]. 38
2263184 1990
381
Inflammatory myofibrohistiocytic proliferation simulating sarcoma in children. 38
2311072 1990
382
[A Japanese family with hereditary HbH disease--a case report and its gene analysis]. 38
2329681 1990
383
[Castleman's disease (giant lymph node hyperplasia): clinical, biological and developing polymorphism. Apropos of 4 cases]. 38
2162141 1990
384
Congenital sideroblastic anemia without clinical iron overload. A case report. 38
2290714 1990
385
[The molecular basis of HbH disease in a Japanese girl]. 38
2618558 1989
386
Capillary growth in anemia-induced ventricular wall remodeling in the rat heart. 38
2529998 1989
387
[Supplementation of essential trace elements during total parenteral nutrition--effects on trace element-deficient rats]. 38
2517760 1989
388
Influence of ochratoxin A and T-2 toxin singly and in combination on broiler chickens. 38
2780475 1989
389
Erythrocytes. 38
2672533 1989
390
The effects of dietary iron supplementation on the toxicity of piroctone olamine in the growing rat. 38
2598828 1989
391
[A case of chronic myelogenous leukemia complicated with nephrotic syndrome]. 38
2529382 1989
392
Aluminum and chronic renal failure: sources, absorption, transport, and toxicity. 38
2647415 1989
393
A new red cell discriminant incorporating volume dispersion for differentiating iron deficiency anemia from thalassemia minor. 38
2620095 1989
394
Small bowel angiodysplasia in association with Crohn's ileitis. A case report. 38
2628394 1989
395
A large deletion encompassing the entire alpha-like globin gene cluster in a family of northern European extraction. 38
2905048 1988
396
"Chordoid" meningeal tumors in young individuals with peritumoral lymphoplasmacellular infiltrates causing systemic manifestations of the Castleman syndrome. A report of seven cases. 38
3383139 1988
397
Zinc-induced copper deficiency. 38
3335323 1988
398
Cardiac transplantation in a Jehovah's witness. 38
15227251 1988
399
[Detection of alpha-thalassemias in patients with microcytic hypochromic anemia or microcytosis by restriction endonuclease mapping]. 38
3167646 1988
400
Heme metabolism and in vitro erythropoiesis in anemia associated with hypochromic microcytosis. 38
3354554 1988
401
Blood studies and performance among calves reared by different methods. 38
3668032 1987
402
Diminished acquisition of iron by reticulocytes from mice with hemoglobin deficit. 38
3595766 1987
403
Infantile-onset arthritis and multisystem inflammatory disease: "a new syndrome". 38
3558812 1987
404
Inhibition of hemoglobin production by transferrin-gallium. 38
3790721 1987
405
Hemoglobin E: another cause of microcytic anemia in North America. 38
3787292 1986
406
Aluminum intoxication in a child: treatment with intraperitoneal desferrioxamine. 38
3763276 1986
407
[Hematological disorders in malignancy]. 38
3013096 1986
408
Alpha thalassemia British type (alpha alpha/--Brit) in an Australian family. 38
3020489 1986
409
Homozygous hemoglobin Knossos (alpha 2 beta 227(B9) Ala----Ser): a new variety of beta (+)-thalassemia intermedia associated with delta (0)-thalassemia. 38
3955238 1986
410
[Abdominal inflammatory pseudotumor (plasma cell granuloma) with anemia and hypergammaglobulinemia]. 38
3704610 1986
411
Hemoglobin SC disease and alpha-thalassemia. Prolonged survival and mild clinical course. 38
3963052 1986
412
Exfoliative dermatitis. A prospective study of 80 patients. 38
2950005 1986
413
Abdominal Hodgkin's disease in a child. 38
3839659 1985
414
Studies of marginal zinc deprivation in rhesus monkeys: VI. Influence on the immunohematology of infants in the first year. 38
4025197 1985
415
Abnormal megakaryocytopoiesis in the Belgrade laboratory rat. 38
3965052 1985
416
Hematology of a murine beta-thalassemia: a longitudinal study. 38
3860141 1985
417
Ferrochelatase deficiency in the bone marrow in a syndrome of congenital hypochromic microcytic anemia, hyperferremia, and iron overload of the liver. 38
3856939 1985
418
Aluminum in tissues. 38
3915959 1985
419
Use of sodium chromate Cr51 in diagnosing childhood idiopathic pulmonary hemosiderosis. 38
6741890 1984
420
Contribution of education to cost-effective care of microcytic, hypochromic anemia. 38
6427387 1984
421
Microcytic hypochromic anemia associated with renal cell carcinoma. 38
6719167 1984
422
Supplementation of milk with iron bound to lactoferrin using weanling mice: L. Effects on hematology and tissue iron. 38
6644450 1983
423
A mouse model for beta-thalassemia. 38
6313205 1983
424
Anemia in the elderly. Common causes and suggested diagnostic approach. 38
6835871 1983
425
Aluminum, parathyroid hormone, and osteomalacia. 38
6422572 1983
426
Hematological findings in the Norrbottnian type of Gaucher disease. 38
7160406 1982
427
[The value of serum ferritin, serum iron and iron-binding capacity in the differential diagnosis of microcytic hypochromic anemia]. 38
7058313 1982
428
[Hemolytic disease of the newborn and chronic hypochromic microcytic anemia in one family: gamma-delta-beta thalassemia]. 38
7330840 1981
429
Comparative toxicity of feeding dried urban sludge and an equivalent amount of cadmium to swine. 38
7325463 1981
430
Malnutrition associated with a formula of barley water, corn syrup, and whole milk. 38
6894664 1981
431
[Thalassemia--a microcytic hypochromic anemia frequently overlooked in the daily practice of outpatient clinic in Japan (author's transl)]. 38
7328766 1981
432
Spontaneous gastric ulcers in a rhesus monkey. 38
7248809 1981
433
Malabsorption and defective utilization of iron in three siblings. 38
7229750 1981
434
Laboratory identification of inherited hemoglobinopathies in children. 38
6162596 1981
435
[Neurological complications in children with congenital cyanotic heart disease (author's transl)]. 38
6107846 1980
436
Acid-base balance and selected hematologic, electrolyte, and blood chemical variables in calves: milk-fed vs conventionally fed. 38
7362116 1980
437
A silent hypocupremic condition in beef cows fed grass silage and the efficacy of sequestered copper to prevent its occurrence. 38
7259027 1980
438
Modification of hemoglobin H disease by sickle trait. 38
479366 1979
439
Bile gastritis without prior gastric surgery: contributing role of cholecystectomy. 38
426202 1979
440
Ochratoxin A-induced iron deficiency anemia. 38
453831 1979
441
[Haematologic disorders in Crohn's disease (author's transl)]. 38
224471 1979
442
[Iron metabolism in siderosensitive and sideroachrestic anemias. Differential diagnosis of hypochromic microcytic anemia]. 38
360024 1978
443
Evaluation of a packaged kit assay of serum ferritin and application to clinical diagnosis of selected anemias. 38
696676 1978
444
beta-Thalassemia arising as a new mutation in an American child. 38
677120 1978
445
Radiation-induced alpha-thalassemia in mice. 38
879556 1977
446
Transferrin loss into the urine with hypochromic, microcytic anemia. 38
1246990 1976
447
Intra-abdominal, angiofollicular lymph node hyperplasia (plasma-cell variant) with an antierythropoietic factor. 38
51137 1975
448
[Hypochromic microcytic anemia and geophagia]. 38
4527391 1974
449
Hereditary sideroblastic anemia and glucose-6-phosphate dehydrogenase deficiency in a Negro family. 38
4871209 1968
450
Hereditary hypochromic microcytic anemia in the laboratory rat. 38
5958911 1966
451
MILK-INDUCED GASTROINTESTINAL BLEEDING IN INFANTS WITH HYPOCHROMIC MICROCYTIC ANEMIA. 38
14162565 1964
452
Hereditary hypochromic microcytic anemia in obstetrics and gynecology. 38
14488836 1962
453
[The effect of ferridextran in hypochromic microcytic anemia]. 38
13888788 1961
454
Glycine in hypochromic microcytic anemia. 38
13644763 1959
455
Hypochromic microcytic anemia of infancy; iron depletion as a factor. 38
13378924 1956
456
[Thalassemia, hereditary hypochromic microcytic anemia]. 38
13360363 1956
457
Supplementary notes on anemia in pregnant women; on the origin and treatment of microcytic hypochromic anemia during toxemias in pregnancy. 38
13252298 1955
458
The pathogenesis of hypochromic microcytic anemia. 38
13163531 1954
459
[Increased lead absorption due to pica in a boy of seven, with achylia gastrica and hypochromic microcytic anemia]. 38
13070822 1953
460
Lymphatic leukemia with a myeloid blood picture complicated by a severe microcytic hypochromic anemia in a dog. 38
21009464 1945

Variations for Hypochromic Microcytic Anemia

Expression for Hypochromic Microcytic Anemia

Search GEO for disease gene expression data for Hypochromic Microcytic Anemia.

Pathways for Hypochromic Microcytic Anemia

Pathways related to Hypochromic Microcytic Anemia according to KEGG:

37 (showing 2, show less)
# Name Kegg Source Accession
1 Lysosome hsa04142
2 Mineral absorption hsa04978

GO Terms for Hypochromic Microcytic Anemia

Cellular components related to Hypochromic Microcytic Anemia according to GeneCards Suite gene sharing:

(showing 6, show less)
# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.72 TMPRSS6 HBB HBA2 HBA1 CP
2 blood microparticle GO:0072562 9.56 HBB HBA2 HBA1 CP
3 cytosolic small ribosomal subunit GO:0022627 9.37 HBA2 HBA1
4 endocytic vesicle lumen GO:0071682 9.33 HBB HBA2 HBA1
5 hemoglobin complex GO:0005833 9.13 HBB HBA2 HBA1
6 haptoglobin-hemoglobin complex GO:0031838 8.8 HBB HBA2 HBA1

Biological processes related to Hypochromic Microcytic Anemia according to GeneCards Suite gene sharing:

(showing 11, show less)
# Name GO ID Score Top Affiliating Genes
1 receptor-mediated endocytosis GO:0006898 9.67 HBB HBA2 HBA1
2 cellular oxidant detoxification GO:0098869 9.63 HBB HBA2 HBA1
3 protein heterooligomerization GO:0051291 9.61 HBB HBA2 HBA1
4 cellular iron ion homeostasis GO:0006879 9.58 TMPRSS6 SLC11A2 CP
5 response to hydrogen peroxide GO:0042542 9.54 HBB HBA2 HBA1
6 positive regulation of cell death GO:0010942 9.5 HBB HBA2 HBA1
7 copper ion transport GO:0006825 9.48 SLC11A2 CP
8 bicarbonate transport GO:0015701 9.43 HBB HBA2 HBA1
9 iron ion homeostasis GO:0055072 9.33 TMPRSS6 STEAP3 SLC11A2
10 hydrogen peroxide catabolic process GO:0042744 9.13 HBB HBA2 HBA1
11 oxygen transport GO:0015671 8.8 HBB HBA2 HBA1

Molecular functions related to Hypochromic Microcytic Anemia according to GeneCards Suite gene sharing:

(showing 8, show less)
# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.54 HBB HBA2 HBA1
2 oxygen binding GO:0019825 9.5 HBB HBA2 HBA1
3 peroxidase activity GO:0004601 9.43 HBB HBA2 HBA1
4 iron ion binding GO:0005506 9.4 HBA2 HBA1
5 oxygen carrier activity GO:0005344 9.33 HBB HBA2 HBA1
6 copper ion binding GO:0005507 9.13 CP
7 organic acid binding GO:0043177 9.13 HBB HBA2 HBA1
8 haptoglobin binding GO:0031720 8.8 HBB HBA2 HBA1

Sources for Hypochromic Microcytic Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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