MCID: HYP028
MIFTS: 25

Hypoglossal Nerve Disease

Categories: Neuronal diseases

Aliases & Classifications for Hypoglossal Nerve Disease

MalaCards integrated aliases for Hypoglossal Nerve Disease:

Name: Hypoglossal Nerve Disease 12 15
Hypoglossal Nerve Diseases 44 70
Disorder of Hypoglossal [12th] Nerve 12
Disorder of Hypoglossal Nerve 12
Disorder of 12th Nerve 12
Disorder of Xii Nerve 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13814
ICD9CM 34 352.5
MeSH 44 D020437
NCIt 50 C26954
SNOMED-CT 67 24777009
ICD10 32 G52.3
UMLS 70 C0152181

Summaries for Hypoglossal Nerve Disease

MalaCards based summary : Hypoglossal Nerve Disease, also known as hypoglossal nerve diseases, is related to epithelioid neurofibroma and neurilemmoma of the fifth cranial nerve. An important gene associated with Hypoglossal Nerve Disease is NF2 (Neurofibromin 2). Affiliated tissues include tongue, uterus and thymus, and related phenotypes are Decreased cell migration and Decreased cell migration

Wikipedia : 73 The hypoglossal nerve is the twelfth cranial nerve, and innervates all the extrinsic and intrinsic... more...

Related Diseases for Hypoglossal Nerve Disease

Diseases related to Hypoglossal Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
# Related Disease Score Top Affiliating Genes
1 epithelioid neurofibroma 10.3 NF2 NF1
2 neurilemmoma of the fifth cranial nerve 10.3 NF2 NF1
3 trigeminal nerve neoplasm 10.3 NF2 NF1
4 cerebral falx meningioma 10.3 NF2 NF1
5 polyp of corpus uteri 10.3 NF2 NF1
6 angular cheilitis 10.3 SLC52A1 AAAS
7 adult malignant schwannoma 10.3 NF2 NF1
8 orbital cancer 10.3 NF2 NF1
9 rete ovarii adenoma 10.3 NF2 NF1
10 rete ovarii benign neoplasm 10.2 NF2 NF1
11 optic nerve glioma 10.2 NF2 NF1
12 neurofibrosarcoma 10.2 NF2 NF1
13 facial nerve neoplasm 10.2 TBX1 NF1
14 obstructive hydrocephalus 10.2 NF2 NF1
15 benign ependymoma 10.2 NF2 NF1
16 lateral medullary syndrome 10.2 SLC52A1 CANX
17 glossopharyngeal neuralgia 10.2 SLC52A1 CANX
18 chordoid glioma 10.2 NF2 KRT7
19 monosomy 22 10.2 SMARCB1 NF2
20 plexiform neurofibroma 10.2 NF2 NF1
21 epididymal neoplasm 10.1 NF1 KRT7
22 sturge-weber syndrome 10.1 NF2 NF1
23 dacryocystocele 10.1 NF1 KRT7
24 chronic inflammation of lacrimal passage 10.1 NF1 KRT7
25 meningioma, radiation-induced 10.1 SMARCB1 NF2
26 rhabdoid meningioma 10.1 SMARCB1 NF2
27 schwannomatosis 1 10.1 SMARCB1 NF2
28 peritoneum cancer 10.1 NF2 KRT7
29 optic nerve astrocytoma 10.1 SMARCB1 NF1
30 cellular neurofibroma 10.1 SMARCB1 NF1
31 clear cell meningioma 10.1 SMARCB1 NF2
32 cerebral ventricle cancer 10.1 SMARCB1 NF2
33 duodenum cancer 10.1 NF1 KRT7
34 cerebrum cancer 10.1 SMARCB1 NF2
35 acoustic neuroma 10.0 NF2 NF1
36 glossopharyngeal nerve disease 10.0 NF2 MUSK CANX
37 supratentorial cancer 10.0 SMARCB1 NF2
38 epidural spinal canal neoplasm 10.0 NF2 MLANA
39 ichthyosis, congenital, autosomal recessive 9 10.0 TBX1 SMARCB1
40 benign mesothelioma 10.0 NF2 KRT7
41 cerebrovascular benign neoplasm 10.0 SMARCB1 KRT7
42 keratinizing squamous cell carcinoma 10.0 SMARCB1 KRT7
43 central epithelioid sarcoma 10.0 SMARCB1 KRT7
44 vulvar melanoma 10.0 NF1 MLANA
45 vulvar proximal-type epithelioid sarcoma 10.0 SMARCB1 KRT7
46 malignant triton tumor 10.0 NF1 MLANA
47 peripheral nerve schwannoma 10.0 SMARCB1 NF2 NF1
48 optic nerve sheath meningioma 10.0 SMARCB1 NF2 NF1
49 plexiform schwannoma 10.0 SMARCB1 NF2 NF1
50 neurilemmoma 10.0 SMARCB1 NF2 NF1

Comorbidity relations with Hypoglossal Nerve Disease via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Hypoglossal Nerve Disease:



Diseases related to Hypoglossal Nerve Disease

Symptoms & Phenotypes for Hypoglossal Nerve Disease

GenomeRNAi Phenotypes related to Hypoglossal Nerve Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 9.43 NF2
2 Decreased cell migration GR00055-A-3 9.43 GJB1 MUSK
3 Increased proliferation GR00094-A 8.62 NF2 SMARCB1

MGI Mouse Phenotypes related to Hypoglossal Nerve Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.56 AAAS CANX GJB1 MUSK NF1 NF2
2 nervous system MP:0003631 9.23 AAAS CANX GJB1 MUSK NF1 NF2

Drugs & Therapeutics for Hypoglossal Nerve Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420

Search NIH Clinical Center for Hypoglossal Nerve Disease

Cochrane evidence based reviews: hypoglossal nerve diseases

Genetic Tests for Hypoglossal Nerve Disease

Anatomical Context for Hypoglossal Nerve Disease

MalaCards organs/tissues related to Hypoglossal Nerve Disease:

40
Tongue, Uterus, Thymus, Spinal Cord, Small Intestine, Kidney, Skin

Publications for Hypoglossal Nerve Disease

Variations for Hypoglossal Nerve Disease

Expression for Hypoglossal Nerve Disease

Search GEO for disease gene expression data for Hypoglossal Nerve Disease.

Pathways for Hypoglossal Nerve Disease

GO Terms for Hypoglossal Nerve Disease

Biological processes related to Hypoglossal Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.26 SMARCB1 KRT7 CANX AAAS
2 negative regulation of MAPK cascade GO:0043409 9.16 NF2 NF1
3 artery morphogenesis GO:0048844 8.62 TBX1 NF1

Sources for Hypoglossal Nerve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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