Hypoglycemia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HYP056 MIFTS: 65	Hypoglycemia Categories: Blood diseases, Endocrine diseases, Genetic diseases, Metabolic diseases	Data Licensing For inquiries, contact: [email protected]
Genes Variations Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Hypoglycemia

MalaCards integrated aliases for Hypoglycemia:

Name: Hypoglycemia ¹¹ ⁷⁵ ²⁸ ⁵³ ⁵ ⁴¹ ⁴³ ¹⁴ ⁷¹ ³³

Hypoglycaemia ¹¹ ¹⁴

Hypoglycaemic Disorder Nos ³³

Spontaneous Hypoglycaemia ³³

Nondiabetic Hypoglycaemia ³³

Hypoglycaemic Syndrome ³³

Hypoglycaemia Nos ³³

Low Blood Sugar ³³

Classifications:

MalaCards categories:
Global: Metabolic diseases Genetic diseases
Anatomical: Endocrine diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Endocrine, nutritional and metabolic diseases

Other disorders of glucose regulation and pancreatic internal secretion

Other disorders of pancreatic internal secretion

Hypoglycaemia, unspecified

ICD11: ³³

Endocrine, nutritional or metabolic diseases

Endocrine diseases

Other disorders of glucose regulation or pancreatic internal secretion

Hypoglycaemia without associated diabetes

External Ids:

Disease Ontology ¹¹ DOID:9993

ICD9CM ³⁴ 251.2

MeSH ⁴³ D007003

NCIt ⁴⁹ C3126

SNOMED-CT ⁶⁸ 154691006

ICD10 ³¹ E16.2

ICD11 ³³ 1004695600

UMLS ⁷¹ C0020615

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Summaries for Hypoglycemia

MedlinePlus: ⁴¹ Hypoglycemia means low blood glucose, or blood sugar. Your body needs glucose to have enough energy. After you eat, your blood absorbs glucose. If you eat more sugar than your body needs, your muscles, and liver store the extra. When your blood sugar begins to fall, a hormone tells your liver to release glucose. In most people, this raises blood sugar. If it doesn't, you have hypoglycemia, and your blood sugar can be dangerously low. Signs include : Hunger Shakiness Dizziness Confusion Difficulty speaking Feeling anxious or weak In people with diabetes, hypoglycemia is often a side effect of diabetes medicines. Eating or drinking something with carbohydrates can help. If it happens often, your health care provider may need to change your treatment plan. You can also have low blood sugar without having diabetes. Causes include certain medicines or diseases, hormone or enzyme deficiencies, and tumors. Laboratory tests can help find the cause. The kind of treatment depends on why you have low blood sugar. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary: Hypoglycemia, also known as hypoglycaemia, is related to hyperinsulinemic hypoglycemia, familial, 2 and hypoglycemia, leucine-induced, and has symptoms including sugar craving An important gene associated with Hypoglycemia is ABCC8 (ATP Binding Cassette Subfamily C Member 8), and among its related pathways/superpathways are Metabolism and PI3K-Akt signaling pathway. The drugs Pancrelipase and Insulin aspart have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and heart, and related phenotypes are homeostasis/metabolism and liver/biliary system

Disease Ontology: ¹¹ A glucose metabolism disease that is characterized by abnormally low levels of blood glucose.

Wikipedia: ⁷⁵ Hypoglycemia, also called low blood sugar, is a fall in blood sugar to levels below normal, typically... more...

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Related Diseases for Hypoglycemia

Diseases related to Hypoglycemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1410)

#	Related Disease	Score	Top Affiliating Genes
1	hyperinsulinemic hypoglycemia, familial, 2	33.6	KCNJ11 INS IGF2 ABCC8
2	hypoglycemia, leucine-induced	33.3	KCNJ11 HADH GLUD1 ABCC8
3	hyperinsulinemic hypoglycemia, familial, 7	33.2	SLC16A1 KCNJ11 HADH GLUD1 GCK ABCC8
4	hyperinsulinemic hypoglycemia, familial, 3	33.2	GCK ABCC8
5	hyperinsulinemic hypoglycemia, familial, 6	33.1	SLC16A1 KCNJ11 HADH GLUD1 GCK ABCC8
6	hyperinsulinemic hypoglycemia	33.1	SLC16A1 KCNJ11 INSR INS IGF2 HADH
7	hyperinsulinemic hypoglycemia, familial, 4	33.0	INSR HADH
8	carnitine palmitoyltransferase ii deficiency, infantile	32.8	SLC25A20 HADH CPT1A ACADVL ACADM
9	hirata disease	32.8	INS GCG
10	type 1 diabetes mellitus	32.6	INS IGF2 GCK GCG
11	carnitine palmitoyltransferase i deficiency	32.5	SLC25A20 HADH CPT1A ACADVL ACADM
12	carnitine-acylcarnitine translocase deficiency	32.5	SLC25A20 CPT1A ACADVL ACADM
13	fructose-1,6-bisphosphatase deficiency	32.5	HADH GCK G6PC1 FBP1 ABCC8
14	acyl-coa dehydrogenase, very long-chain, deficiency of	32.4	SLC25A20 HADH ACADVL ACADM ACADL
15	mitochondrial trifunctional protein deficiency	32.4	SLC25A20 HADH ACADVL ACADM
16	insulinoma	32.4	KCNJ11 INS IGF2 GCK GCG G6PC1
17	hyperinsulinism	32.4	SLC16A1 KCNJ11 INSR INS IGF2 HADH
18	carnitine deficiency, systemic primary	32.4	SLC25A20 HADH ACADVL ACADM
19	glycogen storage disease ia	32.3	INS GYS2 GCG G6PC1 FBP1 AGL
20	glycogen storage disease iii	32.3	GYS2 G6PC1 AGL
21	multiple acyl-coa dehydrogenase deficiency	32.3	SLC25A20 HADH ACADVL ACADM
22	acyl-coa dehydrogenase, medium-chain, deficiency of	32.2	SLC25A20 HADH ACADVL ACADM ACADL
23	glycogen storage disease vi	32.2	GYS2 G6PC1 AGL
24	beckwith-wiedemann syndrome	32.2	SLC16A1 KCNJ11 INS IGF2 HADH ABCC8
25	gestational diabetes	32.1	KCNJ11 INSR INS GCK GCG ABCC8
26	galactosemia i	32.1	HADH ACADVL ACADM
27	hyperglycemia	32.0	KCNJ11 INSR INS GCK GCG G6PC1
28	diabetes mellitus	32.0	KCNJ11 INSR INS IGF2 GCK GCG
29	donohue syndrome	31.9	INSR INS GCK
30	sheehan syndrome	31.9	INS CRH
31	monocarboxylate transporter 1 deficiency	31.9	SLC16A1 INS GLUD1
32	acyl-coa dehydrogenase, short-chain, deficiency of	31.9	HADH ACADVL ACADM
33	islet cell tumor	31.8	INS IGF2 GCG
34	type 2 diabetes mellitus	31.7	KCNJ11 INSR INS IGF2 GCK GCG
35	hypoglycemic coma	31.6	INS IGF2 GCG
36	lactic acidosis	31.5	INS GCG G6PC1 FBP1
37	diabetes mellitus, ketosis-prone	31.4	KCNJ11 INS GCG
38	glycogen storage disease	31.3	INS IGF2 GYS2 G6PC1 AGL
39	potter's syndrome	31.2	INS IGF2
40	prediabetes syndrome	31.2	KCNJ11 INSR INS GCK GCG ABCC8
41	insulin-like growth factor i	31.1	INSR INS IGF2
42	pituitary gland disease	31.1	INS GCG CRH
43	glucose intolerance	31.0	KCNJ11 INSR INS GCK GCG ABCC8
44	asphyxia neonatorum	31.0	SLC16A1 KCNJ11 INS HADH ABCC8
45	abdominal obesity-metabolic syndrome 1	31.0	INS GCK GCG G6PC1 ACADM
46	maturity-onset diabetes of the young	31.0	SLC16A1 KCNJ11 INSR INS IGF2 GCK
47	lipid metabolism disorder	31.0	INSR INS GCG G6PC1 CPT1A ACADVL
48	liver cirrhosis	31.0	INSR INS GCG AGL
49	maturity-onset diabetes of the young, type 1	30.9	KCNJ11 INS GCK ABCC8
50	factitious disorder	30.9	KCNJ11 INS GCK GCG ABCC8

Comorbidity relations with Hypoglycemia via Phenotypic Disease Network (PDN): (show all 31)

Graphical network of the top 20 diseases related to Hypoglycemia:

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Symptoms & Phenotypes for Hypoglycemia

UMLS symptoms related to Hypoglycemia:

sugar craving

GenomeRNAi Phenotypes related to Hypoglycemia according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.18	ABCC8 ACADL ACADM ACADVL AGL CPT1A
2	no effect	GR00402-S-2	10.18	ABCC8 AGL CPT1A CRH FBP1 G6PC1

MGI Mouse Phenotypes related to Hypoglycemia:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.32	ABCC8 ACADL ACADM ACADVL AGL CPT1A
2	liver/biliary system	MP:0005370	10.22	ACADL ACADM ACADVL AGL CRH G6PC1
3	renal/urinary system	MP:0005367	10.2	ACADL AGL CRH G6PC1 GCG GCK
4	growth/size/body region	MP:0005378	10.13	ABCC8 ACADVL AGL CRH G6PC1 GCG
5	muscle	MP:0005369	10.03	ACADM ACADVL AGL GYS2 IGF2 INS
6	adipose tissue	MP:0005375	9.97	ACADVL AGL CRH HADH INS INSR
7	endocrine/exocrine gland	MP:0005379	9.9	ABCC8 CRH GCG GCK GLUD1 HADH
8	cardiovascular system	MP:0005385	9.77	ABCC8 ACADL ACADM ACADVL AGL CPT1A
9	mortality/aging	MP:0010768	9.47	ACADL ACADM ACADVL AGL CPT1A G6PC1

Sources

Drugs & Therapeutics for Hypoglycemia

Drugs for Hypoglycemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 249)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Pancrelipase

Approved, Investigational

Phase 4

53608-75-6

8519

Insulin aspart

Approved

Phase 4

116094-23-6

16132418

Pramlintide

Approved, Investigational

Phase 4

151126-32-8

139600705 70691388

Acarbose

Approved, Investigational

Phase 4

56180-94-0

441184 444254

Zinc cation

Approved, Experimental, Investigational

Phase 4

7440-66-6, 23713-49-7

32051

Glyburide

Approved

Phase 4

10238-21-8

3488

Vildagliptin

Approved, Investigational

Phase 4

274901-16-5

6918537

Liraglutide

Approved

Phase 4

204656-20-2

44147092 16134956

Lixisenatide

Approved

Phase 4

320367-13-3

90472060 16139342

Gliclazide

Approved

Phase 4

21187-98-4

3475

Empagliflozin

Approved

Phase 4

864070-44-0

73151030 11949646

Verapamil

Approved

Phase 4

152-11-4, 52-53-9

2520

Ciprofloxacin

Approved, Investigational

Phase 4

85721-33-1, 93107-08-5

2764

Levofloxacin

Approved, Investigational

Phase 4

100986-85-4

149096

Ofloxacin

Approved

Phase 4

82419-36-1

4583

Spironolactone

Approved

Phase 4

1952-01-7, 52-01-7

5833

Betamethasone

Approved, Vet_approved

Phase 4

378-44-9

9782

Diazoxide

Approved

Phase 4

364-98-7

3019

Insulin glargine

Approved

Phase 4

160337-95-1

118984454

Insulin detemir

Approved

Phase 4

169148-63-4

16137271

Gastric inhibitory polypeptide

Investigational

Phase 4

100040-31-1

Hypoglycemic Agents

Phase 4

Insulin, Globin Zinc

Phase 4

Insulin

Phase 4

Pancreatin

Phase 4

Antihypertensive Agents

Phase 4

Vasodilator Agents

Phase 4

Cardiac Glycosides

Phase 4

Glycoside Hydrolase Inhibitors

Phase 4

Cytochrome P-450 Enzyme Inhibitors

Phase 4

calcium channel blockers

Phase 4

Insulin degludec, insulin aspart drug combination

Phase 4

Cathartics

Phase 4

Laxatives

Phase 4

(1-6)-alpha-glucomannan

Phase 4

Manna

Phase 4

Insulin aspart, insulin aspart protamine drug combination 30:70

Phase 4

Biphasic Insulins

Phase 4

Insulin, Long-Acting

Phase 4

Insulin, Isophane

Phase 4

Isophane Insulin, Human

Phase 4

Isophane insulin, beef

Phase 4

Diuretics, Potassium Sparing

Phase 4

diuretics

Phase 4

Mineralocorticoids

Phase 4

Mineralocorticoid Receptor Antagonists

Phase 4

Betamethasone-17,21-dipropionate

Phase 4

Betamethasone Valerate

Phase 4

2152-44-5

Betamethasone sodium phosphate

Phase 4

Betamethasone benzoate

Phase 4

Interventional clinical trials:

(show top 50) (show all 584)

#	Name	Status	NCT ID	Phase	Drugs
1	Glucose Control During Labour in Gestational Diabetes Mellitus With Insulin Treatment: Insulin-Glucose-Infusion Versus Observational Approach - Is There a Difference in Neonatal Hypoglycemia Rate?	Unknown status	NCT02590016	Phase 4	Insulin, Aspart
2	Pasireotide in the Treatment of Hypoglycemia Following Gastric Bypass Surgery	Unknown status	NCT03514576	Phase 4	Pasireotide 0.3 MG/ML
3	Treatment of Hypoglycemia With Glucagon Among Patients With Type 1 Diabetes Mellitus	Unknown status	NCT02232971	Phase 4	Glucagon
4	Do Sulphonylureas Preserve Cortical Function During Hypoglycaemia?	Unknown status	NCT00472875	Phase 4	Glibenclamide
5	Pramlintide (Symlin) for the Treatment of Hypoglycemia Following Gastric Bypass Surgery	Completed	NCT01841359	Phase 4	Pramlintide
6	NEONATAL HYPOGLYCEMIA and CONTINUOUS GLUCOSE MONITORING: A RANDOMIZED CONTROLLED TRIAL IN PRETERM INFANTS	Completed	NCT02583776	Phase 4
7	The Effect of Sitagliptin on Glucagon Counterregulation and Incretin Hormones During Mild Hypoglycemia in Elderly Patients With Metformin-treated Type 2 Diabetes	Completed	NCT02256189	Phase 4	Sitagliptin;Placebo
8	Treatment With Sitagliptin Phosphate in Patients With Reactive Hypoglycemia Secondary to Dysinsulinism. A Controlled, Randomized, Double-blind, Clinical Trial	Completed	NCT00847080	Phase 4	Sitagliptin phosphate;Placebo
9	Effect of Lixisenatide on Glucagon Secretion During Hypoglycemia in Patients With Insulin-treated Type 2 Diabetes	Completed	NCT02020629	Phase 4	Lixisenatide
10	Target Glycemic Control and the Incidence of Documented Symptomatic Hypoglycemia in Insulin naïve Subjects With Type 2 Diabetes Failing on Oral Hypoglycemic Agent(s) and Treated With Insulin Glargine or Insulin Detemir.	Completed	NCT00405418	Phase 4	Insulin glargine;Insulin Detemir
11	The Incidence of Hypoglycemia in Insulin Glargine-Treated Subjects With Diabetes Mellitus Upon Switching Between Bedtime and Morning Dosing	Completed	NCT00609895	Phase 4	INSULIN GLARGINE
12	An Open-Label, Randomized Naturalistic Study to Evaluate the Incidence of Hypoglycemia Comparing Sitagliptin With Sulfonylurea Treatment in Patients With Type 2 Diabetes During Ramadan Fasting	Completed	NCT01131182	Phase 4	Sitagliptin phosphate;Comparator: Sulfonylurea;Metformin
13	Study of the Effect of Vildagliptin on Glucagon Counterregulation Response During Hypoglycemia in Patients With Type 1 Diabetes	Completed	NCT01147276	Phase 4	Vildagliptin
14	Treatment of Hypoglycemia Following Gastric Bypass Surgery	Completed	NCT02527993	Phase 4	Glucobay (acarbose);Januvia (sitagliptin);Verapamil HEXAL (verapamil);Victoza (liraglutide);Signifor (pasireotide)
15	A Multicenter, Prospective, Randomized, Open-label, Parallel Group Study to Investigate the Clinical Benefit on Hypoglycemia Frequency of 24 Weeks Treatment With Galvus Versus Usual Care (Any OAD of Another Class Added to Metformin Within SmPc) in Older Patients With Type 2 Diabetes Insufficiently Controlled by Metformin Monotherapy.	Completed	NCT01238978	Phase 4	Vildagliptin;"Usual Care"
16	Study of the Effect of Vildagliptin on Glucagon Counterregulation Response During Hypoglycemia in Insulin-treated Patients With Type 2 Diabetes	Completed	NCT01219400	Phase 4	Vildagliptin
17	Glycemic Excursions in Type 2 Diabetic Patients Treated With Vildagliptin and Metformin (GalvusMet) Versus Glimepiride and Metformin	Completed	NCT02007278	Phase 4	vildagliptin and metformin (combination);glimepiride;Metformin
18	Bedtime Insulin Glargine or Bedtime Neutral Protamine Lispro Combined With Sulfonylurea and Metformin in Type 2 Diabetes. A Randomized, Controlled Trial	Completed	NCT00641407	Phase 4	NPL insulin;Insulin glargine
19	Randomized, Double-blind, Placebo-controlled Crossover Trial Assessing the Impact of the SGLT2 Inhibitor Empagliflozin on Postprandial Hypoglycaemia After Gastric Bypass	Completed	NCT05057819	Phase 4	Empagliflozin 25 MG;Placebo
20	Glucagon Efficiency After High and Low Carbohydrate Diet	Completed	NCT02578498	Phase 4
21	The Effect of Glucomannan Soluble Fiber on Glucose Homeostasis in Patients With RNY Gastric Bypass Surgery	Completed	NCT02336438	Phase 4
22	Phase IV Study to Compare the Accuracy and Precission of Five Different Home Glucose Monitors;Optium Xceed, Contour Ts, Accu-chek Go, One Touch Select and Ez Smart	Completed	NCT01013402	Phase 4	Human insulin;Human Insulin
23	Dual-hormone Closed-loop Glucose Control in Type 1 Diabetes	Completed	NCT04053712	Phase 4	Glucagon
24	Effect of Ciprofloxacin Versus Levofloxacin on QTc-interval and Dysglycemia in Diabetic and Non-Diabetic Patients.	Completed	NCT04456712	Phase 4	Ciprofloxacin 400 MG/200 ML Intravenous Solution;Levofloxacin 750 MG
25	The Effect of Insulin Degludec on Risk of Symptomatic Nocturnal Hypoglycaemia in Subjects With Type 1 Diabetes and High Risk of Nocturnal Severe Hypoglycaemia	Completed	NCT02192450	Phase 4	Insulin aspart/glargine;Insulin aspart/degludec
26	The Late Effects of Ethanol Intake on the Glucose Response to Subcutaneous Glucagon in Type 1 Diabetes	Completed	NCT02881060	Phase 4
27	A Phase IIIb/IV, Multinational, Multicentre, Randomised, Open Study to Establish the Optimal Method for Initiating and Maintaining Lantus® (Insulin Glargine) Therapy Based on a Comparison of Two Treatment Algorithms to Determine Optimal Metabolic Outcomes, Safety, and Satisfaction in Subjects With Type 1 Diabetes Mellitus/ "HALT" Sub-study: Multicentre, Open Clinical Trial to Assess the Effect of Insulin Glargine on Symptomatic Hypoglycaemia, Fear of Hypoglycaemia and Quality of Life in Patients With Type 1 Diabetes	Completed	NCT00390728	Phase 4	Insulin Glargine
28	Can Hypoglycaemia Awareness Be Restored in Individuals With Type 1 Diabetes and Severe Hypoglycaemia Employing Optimised Subcutaneous Insulin Regime or Continuous Subcutaneous Insulin Infusion Pump	Completed	NCT00360984	Phase 4	insulin glargine
29	The Effect of Insulin Analogues and Human Insulin on the Incidence of Severe Hypoglycaemia in Hypoglycaemia Prone Type 1 Diabetic Patients	Completed	NCT00346996	Phase 4	insulin levemir / aspart;human insulin /insulin isophane
30	Use of Diazoxide in Acute Hypoglycaemia	Completed	NCT01488136	Phase 4	Diazoxide;Placebo
31	A Double-blind, Randomised, Crossover Study to Investigate the Difference in Frequency of Episodes of Hypoglycaemia During Treatment With Biphasic Insulin Aspart 30 Compared to Biphasic Human Insulin 30 in Patients With Well-controlled Type 2 Diabetes	Completed	NCT01487798	Phase 4	biphasic human insulin 30;biphasic insulin aspart 30
32	A Randomised, Parallel-group, Open-label, Multinational Trial Comparing the Safety and Efficacy of Insulin Aspart (NovoRapid®) Versus Human Insulin (Actrapid®), Used in a Multiple Injection Regimen, in the Treatment of Pregnant Women With Type 1 Diabetes, Focusing on Maternal Hypoglycaemia and Pregnancy Outcomes	Completed	NCT00365170	Phase 4	human insulin;insulin aspart
33	Liraglutide in Type 1 Diabetes. A Randomised, Double-blind, Placebo Controlled Study of the Effect of Liraglutide as an Additional Treatment to Insulin on HbA1c, Body Weight and Hypoglycaemia in Poorly Regulated Type 1 Diabetes Patients	Completed	NCT01612468	Phase 4	Liraglutide;Placebo
34	The Effect of Long- and Intermediate-acting Insulins on Glycemic Control and Risk of Hypoglycemia Among Toddlers and Preschool Children With Newly Onset Type 1 Diabetes Mellitus: A Randomized Three Armed Trial	Recruiting	NCT04664764	Phase 4	Degludec;Glargine;NPH insulin
35	The Effect of Metformin in Pregnant Women Who Received Antenatal Corticosteroids on Glycemic Control and the Rate of Neonatal Hypoglycemia - Multicenter Prospective Randomized, Controlled Trial	Recruiting	NCT04332393	Phase 4	Metformin
36	A Randomized Cross-over Trial Evaluating Automated Insulin Delivery Technologies on Hypoglycemia and Quality of Life in Elderly Adults With Type 1 Diabetes	Recruiting	NCT04016662	Phase 4
37	Difference of Basal Insulin Titration Method in Reducing HbA1c Among Type 2 Diabetes Mellitus (T2DM) Patients.	Recruiting	NCT05331469	Phase 4	NPH basal insulin titration
38	Hypoglycemia and Autonomic Nervous System Function	Active, not recruiting	NCT03429946	Phase 4	Spironolactone;Placebo
39	Timing of Late Preterm Corticosteroid Administration and Neonatal Hypoglycemia	Not yet recruiting	NCT04869709	Phase 4	Betamethasone Sodium Phosphate
40	Novel Approach for the Prevention of Hypoglycemia Associated Autonomic Failure (HAAF)	Suspended	NCT03608163	Phase 4	Naloxone;Diazoxide;Placebo (for Naloxone);Placebo (for Diazoxide)
41	Effects of Insulin Detemir Versus Regular Insulin (Actrapid) on Hormonal Counterregulation, Cognitive Function and Symptom Perception During Hypoglycemia	Terminated	NCT00490893	Phase 4	Detemir
42	Randomized Double Blind Parallel Design Study Comparing Risk of Nocturnal Hypoglycemia and Critical Arrhythmia With Sitagliptin Versus Glimepiride in Patients With Type 2 Diabetes Insufficiently Controlled With Metformin Monotherapy	Terminated	NCT02373865	Phase 4	Sitagliptin;Glimepiride;Sitagliptin-Placebo;Glimepiride-Placebo
43	Comparison of Neutral Protamine Hagedorn (NPH) and Lantus Based Insulin Regimen in the Management of Hypoglycemia in the Hospitalized Patients in Noncritical Care Setting	Terminated	NCT02189395	Phase 4	NPH and regular insulin;glargine and humalog
44	Sitagliptin Versus Sulphonylurea Based Treatments in Muslim Patients With Type 2 Diabetes During Ramadan	Terminated	NCT00766441	Phase 4	Sitagliptin;sulphonylurea
45	Comparison of Two Strategies of Hypoglycemia Correction in ICU	Withdrawn	NCT01387477	Phase 4	Lactate;Glucose
46	Use for Diazoxide in the Initial Management of Hypoglycemia in Infants of Diabetic Mothers and Infants Large for Gestation	Unknown status	NCT00994149	Phase 2, Phase 3	Diazoxide;Ora-plus
47	To Examine if the Mother's Glucose Levels and Glucose Levels in the Blood Can Predict Cord Hypoglycemia in Newborns at Risk.	Unknown status	NCT02838875	Phase 3
48	G-Pen (Glucagon Injection) Compared to GlucaGen® Hypokit® (Glucagon) for Induced Hypoglycemia Rescue in Adults With T1D: A Phase 3 Multi-center, Randomized, Controlled, Single Blind, 2-way Crossover Study to Evaluate Efficacy and Safety	Completed	NCT03738865	Phase 3	G-Pen;Novo Glucagon
49	G-Pen™ (Glucagon Injection) Compared to Lilly Glucagon (Glucagon for Injection [RDNA Origin]) for Induced Hypoglycemia Rescue in Adults With T1D: a Phase 3 B Multi-Centered, Randomized, Controlled, Single Blind, 2-Way Crossover Study to Evaluate Efficacy and Safety	Completed	NCT03439072	Phase 3	G-Pen;Lilly Glucagon
50	A Randomized, Double-blind, Parallel-group Trial to Confirm the Clinical Efficacy and Safety of Dasiglucagon in the Rescue Treatment of Hypoglycemia in Subjects With Type 1 Diabetes Mellitus (T1DM) Compared to Placebo	Completed	NCT03688711	Phase 3	Dasiglucagon;Placebo

Search NIH Clinical Center for Hypoglycemia

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

DEXTROSE 100% PWDR

Diazoxide

Glucagon

Glucose

GLUCOSE LIQUID

Cochrane evidence based reviews: hypoglycemia

Sources

Genetic Tests for Hypoglycemia

Genetic tests related to Hypoglycemia:

#	Genetic test	Affiliating Genes
1	Hypoglycemia ²⁸

Sources

Anatomical Context for Hypoglycemia

Organs/tissues related to Hypoglycemia:

MalaCards : Liver, Kidney, Heart, Brain, Pancreas, Pancreatic Islet, Pituitary

Sources

Publications for Hypoglycemia

Articles related to Hypoglycemia:

(show top 50) (show all 41568)

#	Title	Authors	PMID	Year
1	Immunogenicity, Efficacy, and Safety of Biosimilar Insulin Aspart (MYL-1601D) Compared with Originator Insulin Aspart (Novolog®) in Patients with Type 1 Diabetes After 24 Weeks: A Randomized Open-Label Study. ⁶² ⁴¹	Blevins TC...Barve A	36114990	2022
2	Neurocognitive Outcomes at Age 2 Years After Neonatal Hypoglycemia in a Cohort of Participants From the hPOD Randomized Trial. ⁶² ⁴¹	Edwards T...Harding JE	36219444	2022
3	Impact of tight glycemic control and hypoglycemia after pediatric cardiac surgery on neurodevelopmental outcomes at three years of age: Findings from a randomized clinical trial. ⁶² ⁴¹	Sadhwani A...Agus MSD	36071424	2022
4	IGF2 over-expression in solitary fibrous tumours is independent of anatomical location and is related to loss of imprinting. ⁵³ ⁶²	Hajdu M...Antonescu CR	20527023	2010
5	Prolonged survival and improved glycemia in BioBreeding diabetic rats after early sustained exposure to glucagon-like peptide 1. ⁵³ ⁶²	Yanay O...Osborne WR	20527046	2010
6	[A new therapeutic possibility for type 2 diabetes: DPP-4 inhibitors (sitagliptin)]. ⁵³ ⁶²	Abel T...Feher J	20519186	2010
7	Type 2 diabetes comorbidities and treatment challenges: rationale for DPP-4 inhibitors. ⁵³ ⁶²	Hollander PA...Kushner P	20463416	2010
8	Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations. ⁵³ ⁶²	Flanagan SE...Ellard S	20164212	2010
9	Prevention of nocturnal hypoglycemia using predictive alarm algorithms and insulin pump suspension. ⁵³ ⁶²	Buckingham B...Doyle FJ	20200307	2010
10	Glucose transporter type 1 deficiency: ketogenic diet in three patients with atypical phenotype. ⁵³ ⁶²	Veggiotti P...Balottin U	19515520	2010
11	Transient salt wasting in POMC-deficiency due to infection induced stress. ⁵³ ⁶²	Darcan S...Asar G	19998238	2010
12	Brain glucosamine boosts protective glucoprivic feeding. ⁵³ ⁶²	Osundiji MA...Evans ML	20179264	2010
13	A case of a giant phyllodes tumor of the breast with hypoglycemia caused by high-molecular-weight insulin-like growth factor II. ⁵³ ⁶²	Hino N...Tsuyuguchi M	19259766	2010
14	Improved glycaemic control with minimal hypoglycaemia and no weight change with the once-daily human glucagon-like peptide-1 analogue liraglutide as add-on to sulphonylurea in Japanese patients with type 2 diabetes. ⁵³ ⁶²	Kaku K...Seino Y	20380655	2010
15	Effects of incretin hormones on beta-cell mass and function, body weight, and hepatic and myocardial function. ⁵³ ⁶²	Mudaliar S...Henry RR	20206728	2010
16	Solitary fibrous tumor of soft tissue: a case report and immunohistochemical study. ⁵³ ⁶²	Yuri T...Tsubura A	20340008	2010
17	Type B insulin resistance syndrome with systemic lupus erythematosus. ⁵³ ⁶²	Sato N...Tomino Y	20129024	2010
18	Therapeutic options that provide glycemic control and weight loss for patients with type 2 diabetes. ⁵³ ⁶²	Blevins T	20107301	2010
19	Hypoglycemia due to ectopic secretion of insulin-like growth factor-I in a patient with an isolated sarcoidosis of the spleen. ⁵³ ⁶²	Ogiwara Y...Ito H	20081321	2010
20	A novel mutation in the glycogen synthase 2 gene in a child with glycogen storage disease type 0. ⁵³ ⁶²	Soggia AP...Pereira MA	20051115	2010
21	[Late onset 3-HMG-CoA lyase deficiency: a rare but treatable disorder]. ⁵³ ⁶²	Pierron S...Acquaviva C	19932602	2010
22	Reaching HbA1c goals with saxagliptin in combination with other oral antidiabetic drugs. ⁵³ ⁶²	LaSalle JR	20107298	2010
23	In vivo phosphoenolpyruvate carboxykinase promoter mapping identifies disrupted hormonal synergism as a target of inflammation during sepsis in mice. ⁵³ ⁶²	Chichelnitskiy E...Herzig S	19821526	2009
24	Novel FBP1 gene mutations in Arab patients with fructose-1,6-bisphosphatase deficiency. ⁵³ ⁶²	Faiyaz-Ul-Haque M...Zaidi SH	19259699	2009
25	Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia. ⁵³ ⁶²	Osbak KK...Gloyn AL	19790256	2009
26	Treatment of type 1 diabetic patients with glucagon-like peptide-1 (GLP-1) and GLP-1R agonists. ⁵³ ⁶²	Kielgast U...Madsbad S	19925391	2009
27	Differential effects of insulin detemir and neutral protamine Hagedorn (NPH) insulin on hepatic glucose production and peripheral glucose uptake during hypoglycaemia in type 1 diabetes. ⁵³ ⁶²	Smeeton F...Russell-Jones DL	19707744	2009
28	Hyperinsulinaemic hypoglycaemia associated with a heterozygous missense mutation of R1174W in the insulin receptor (IR) gene. ⁵³ ⁶²	Huang Z...Weng J	19170714	2009
29	DPP-4 inhibitors in clinical practice. ⁵³ ⁶²	Palalau AI...Barnett AH	19940419	2009
30	Malignant solitary fibrous tumor: report of 3 cases with unusual features. ⁵³ ⁶²	Hu Y...Xu H	19349855	2009
31	New therapies for diabesity. ⁵³ ⁶²	Bailey CJ	19793506	2009
32	Treatment of dwarfism with recombinant human insulin-like growth factor-1. ⁵³ ⁶²	Ranke MB...Bettendorf M	19946434	2009
33	No increased risk of hypoglycaemic episodes during 48 h of subcutaneous glucagon-like-peptide-1 administration in fasting healthy subjects. ⁵³ ⁶²	Lerche S...Brock B	19094067	2009
34	Liraglutide: a once-daily incretin mimetic for the treatment of type 2 diabetes mellitus. ⁵³ ⁶²	Neumiller JJ...Campbell RK	19638470	2009
35	Selecting among ADA/EASD tier 1 and tier 2 treatment options. ⁵³ ⁶²	McGill JB	19744422	2009
36	Differential chemistry (structure), mechanism of action, and pharmacology of GLP-1 receptor agonists and DPP-4 inhibitors. ⁵³ ⁶²	Neumiller JJ	19801361	2009
37	Beta-human chorionic gonadotropin production associated with phyllodes tumor of the breast: an unusual paraneoplastic phenomenon. ⁵³ ⁶²	Reisenbichler ES...Hameed O	19624411	2009
38	Defining the importance of daily glycemic control and implications for type 2 diabetes management. ⁵³ ⁶²	Bode BW	19820277	2009
39	Hypoglycemia with intensive insulin therapy in critically ill patients: predisposing factors and association with mortality. ⁵³ ⁶²	Arabi YM...Rishu AH	19623047	2009
40	[Diagnosis of glycogen storage disease type IIIA by detecting glycogen debranching enzyme activity, glycogen content and structure in muscle]. ⁵³ ⁶²	Wang W...Li F	19951495	2009
41	Short-term effects of the long-acting insulin analog detemir and human insulin on plasma levels of insulin-like growth factor-I and its binding proteins in humans. ⁵³ ⁶²	Porcellati F...Fanelli CG	19470629	2009
42	Hemangiopericytoma-associated hypoglycemia improved by glucocorticoid therapy: a case report. ⁵³ ⁶²	Anaforoglu I...Algun E	19387873	2009
43	Treatment of type 2 diabetes with glucagon-like peptide-1 receptor agonists. ⁵³ ⁶²	Hansen KB...Vilsboll T	19624785	2009
44	Hypoglycemia from IGF2 overexpression associated with activation of fetal promoters and loss of imprinting in a metastatic hemangiopericytoma. ⁵³ ⁶²	Lawson EA...Klibanski A	19383775	2009
45	[A case of retroperitoneal solitary fibrous tumor associated with hypoglycemia]. ⁵³ ⁶²	Kawashima A...Kitaoka H	19673425	2009
46	3-Hydroxyacyl-coenzyme A dehydrogenase deficiency and hyperinsulinemic hypoglycemia: characterization of a novel mutation and severe dietary protein sensitivity. ⁵³ ⁶²	Kapoor RR...Hussain K	19417036	2009
47	Lys169 of human glucokinase is a determinant for glucose phosphorylation: implication for the atomic mechanism of glucokinase catalysis. ⁵³ ⁶²	Zhang J...Jiang H	19617908	2009
48	Expression of insulin-like growth factor 2 in mesenchymal neoplasms. ⁵³ ⁶²	Steigen SE...Nielsen TO	19407853	2009
49	Factors determining inadequate hypoglycaemia during insulin tolerance testing (ITT) after pituitary surgery. ⁵³ ⁶²	Lee P...Ho KK	19178524	2009
50	Delay in blood glucose monitoring during an insulin infusion protocol is associated with increased risk of hypoglycemia in intensive care units. ⁵³ ⁶²	Garg R...Pendergrass M	19670374	2009

Sources

Genes for Hypoglycemia

Genes related to Hypoglycemia (2 elite genes):

(show top 50) (show all 79)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	ABCC8	ATP Binding Cassette Subfamily C Member 8	Protein Coding	472	Pathogenic ⁵ Likely pathogenic ⁵ DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications Summaries (show sections)	2166699 8314007 10615958 (more) 10334322 8751851 11226335 9648840 18339976 18250167 11938023 12199344 16023110 12453898 10323384 8923010 11772909 15356046 11867634 9041101 12606521 7633448 8650576 9100595
2	G6PC1	Glucose-6-Phosphatase Catalytic Subunit 1	Protein Coding	442.11	Pathogenic ⁵ DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications Summaries (show sections)	8949949 10625614 11899241 (more) 17023421 12189168 12373573 18996862
3	KCNJ11	Potassium Inwardly Rectifying Channel Subfamily J Member 11	Protein Coding	70.75	Likely pathogenic ⁵ DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications Summaries (show sections)	16142506 10615958 19214942 (more) 10334322 11938023 11867634 12199344 8923010 9648840 10323384 12453898
4	GCG	Glucagon	Protein Coding	46.44	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Proteins Functions (show sections)	9794105 12941722 12547550 (more) 11889194 18957502 17698900 19094067 7627258 7672496 11383230 19170358 20380655 19638470 19439067 16338283 9831697 20527046 16629719 16490580 16682937 15585995 19925391 19591659 19555131 18769687 11575444 9802745 9200302 17719327 16132964 16120042 10630380 12973381 19793506 17174230 16855072 7612912 16179267 8894501 19707284 18600596
5	GCK	Glucokinase	Protein Coding	43.78	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications Summaries (show sections)	14517946 15277402 19790256 (more) 19336674 20179264 10480597 10525657 12941786 11916904 11119017 12475782 16938872 18489404 17082186 10805170 19617908 18325809 18370929 18208578 17976205 11916951 12228011 15677479 16159025
6	HADH	Hydroxyacyl-CoA Dehydrogenase	Protein Coding	41.29	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications Summaries (show sections)	17491019 14693719
7	ACADM	Acyl-CoA Dehydrogenase Medium Chain	Protein Coding	40.56	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications Summaries (show sections)	2387217 7929823 9498103 (more) 1594327 1539377 11229423 10529389 18753599 8017963 15053333 15858970
8	SLC25A20	Solute Carrier Family 25 Member 20	Protein Coding	40.32	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications Summaries (show sections)	15363639 8450053 11350184 (more) 15365988 16602102 10655160 15159657 12507404
9	GYS2	Glycogen Synthase 2	Protein Coding	40.19	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications Summaries (show sections)	20051115 11483824
10	INS	Insulin	Protein Coding	39.81	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	7557152 17405845 7859599 (more) 15143456 8325948 9148220 15251622 10975210 9162611 18484562 11544612 7895957 19366775 11012567 10934454 11220353 14585087 1932902 18715200 16025296 1956736 1830533 10971447 10969839 17285009 15855577 19178524 12831635 8443479 2272633 15356061 15901524 8840097 1351127 1678798 18083783 15375778 12610018 11430183 19318387 17521012 16569758 9773738 9113474 7895456 16374162 15209772 20200307 17415551 15734853 10910009 11460588 7743760 16249541 1954812 19440117 15551297 12734137 2237055 10778865 10392347 10669122 9368685 7988782 7983527 8029194 1826237 2184211 19436668 19024537 18959604 17023087 12610006 9932217 8884164 8136620 8299480 1979763 2192194 1932903 19670374 15671916 11926785 19667675 12371641 11225967 9255188 7586616 8485954 2194712 19623047 16175061 10523009 9135698 7523002 2198433 19707744 11315820 9096968 8425662 1430091 2224606 17916634 17550216 12174321 9141533
11	ACADL	Acyl-CoA Dehydrogenase Long Chain	Protein Coding	36.72	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications Summaries (show sections)	1945557 9861014 8517612
12	FBP1	Fructose-Bisphosphatase 1	Protein Coding	36.19	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications Summaries (show sections)	19259699
13	IGF2	Insulin Like Growth Factor 2	Protein Coding	34.6	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	1281841 19259766 9790231 (more) 2170553 2205424 10586596 8021581 18490836 8760024 10931103 14709848 7545698 7525443 1792643 16860583 19383775 11334396 7524924 10468998 8082393 9773947 2086202 9876347 7685912 11149628 9737571 7724120 2159026 15626921 7715546 7688378 2256261 11518119 8772589 8205358 20527023 16490691 19349855 16682842 9236865 18552458 9589464 8772551 8759187 7514593 8204962 9758443 1716259 1311795 1318326 9709962 7989458 1320177 1720806 19387873 16170199 11777215 9647037 9628278 9113488 19624411 17299065 16935145 15575249 10725783 10674040 9854213 9340344 9046989 8710034 7750199 8929651 1618998 19502525 16227169 15227844 11549873 10633872 9554538 7658270 7771502 20340008 18045950 16882067 15727393 15223980 12324491 9849819 9095642 1635777 1718747 19407853 19673425 8950621 7476305 12606521 7525121 15251701 16981978
14	SLC16A1	Solute Carrier Family 16 Member 1	Protein Coding	34.29	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications Proteins (show sections)	17701893
15	ACADVL	Acyl-CoA Dehydrogenase Very Long Chain	Protein Coding	32.18	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	16199475 16435213 17206456 (more) 12359260 8809347 16621643 19156135 16880373 15025677 19208414 11433098 15845636
16	GLUD1	Glutamate Dehydrogenase 1	Protein Coding	32.12	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	11872671 12444083 15530324 (more) 15756227 18321734 14532172
17	CRH	Corticotropin Releasing Hormone	Protein Coding	30.86	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Summaries (show sections)	7586616 1309389 1331166 (more) 1966026 8582421 9203994 1400870 1285360 7496087 15879359 9558010 9483705 1648460 7556777 8327371 8386766 10811293 9652904 7704086 1966779 16669599 16266629 11788380 11779371 10939538 8582717 1322422 9676772 8817725 11197891 1323248 8706296 8835601
18	CPT1A	Carnitine Palmitoyltransferase 1A	Protein Coding	30.46	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	16870691 11286380 15669684 (more) 10407779 16602102 12189492 14517221
19	INSR	Insulin Receptor	Protein Coding	30.33	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	11217151 17956452 17296513 (more) 19170714 19318401 1874939 14722613 17299733 16761106 7821734 11443207 10443650 17445543 8348701 1727740 19411227 15992683 14764948 12794609 10500933 16227169 10633872 20129024 18691043 15111569 14694017 18156285
20	AGL	Amylo-Alpha-1, 6-Glucosidase, 4-Alpha-Glucanotransferase	Protein Coding	30.18	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	8990006 18717245 19951495 (more) 17895567
21	CPT2	Carnitine Palmitoyltransferase 2	Protein Coding	29.96	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	18471680 1999498 12410208
22	GCGR	Glucagon Receptor	Protein Coding	28.26	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	9186298 16174875
23	DPP4	Dipeptidyl Peptidase 4	Protein Coding	27.27	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	18641927 19444259 19820277 (more) 19170358 11394909 16855072 17160910 20107298 20206728 20463416 20519186 16629719 17300591 16338283 17593274 19555131 19940419
24	PCK2	Phosphoenolpyruvate Carboxykinase 2, Mitochondrial	Protein Coding	26.71	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	19821526 10599987 17456789 (more) 8932991
25	GLP1R	Glucagon Like Peptide 1 Receptor	Protein Coding	25.05	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	19318378 19444259 19624785 (more) 19801361 19744422 20107301
26	SST	Somatostatin	Protein Coding	25.04	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15855577 11334393 1673342 (more) 12547550 8093619 1915515 7904782 8903503 10672712 16949024 9445586 8421084 2113855 10883468 8410522 2159483 9364348 2184212 17124362 1976218 2185966 19409239 12200764 11840663 9828742 9401640 8772551 8095006 16284426 1493086 2035626 1350344 1674642 1901390 1671783 2106191 17490935 16284444 11834428 11704779 9681860 17047390 1970540 1904602 1889145 12602474
27	MYOM1	Myomesin 1	Protein Coding	25	Likely pathogenic ⁵
28	IGF1	Insulin Like Growth Factor 1	Protein Coding	25	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	18644070 17299065 2205424 (more) 15898344 16449027 16548790 7679407 16610982 9849819 1792643 2027818 20081321 7523002 7536210 8088711 17380212 11956148 8300052 9267949 15251701 1311795 7525121 19946434 7514593 8772589 7486340 2033287 2239085 19128470 12213663 7735377 7525624 7518727 9046989 8174311 8243878 1295817 1377706 7966079 19470629 19387873 2183688 18825882 18376417 18419060 16682842 12870155 10435054 9329386 7920992 8498545 2170553 11306751 11308044 15579776 11549873 10487673 9626125 9492063 8928757 7545698 7771502 12030603 9701698 9496559 9113488 7476318 7957405 1403403 7509217 1490658 1379258 16843952 17483375 15001620 11508780 8854134 8300055 7599690 7512681 18952825 16981978 14601488 12968060
29	HADHB	Hydroxyacyl-CoA Dehydrogenase Trifunctional Multienzyme Complex Subunit Beta	Protein Coding	24.97	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	19417036
30	GYS1	Glycogen Synthase 1	Protein Coding	24.87	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	8635676 8200993
31	POMC	Proopiomelanocortin	Protein Coding	24.51	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9781630 10523009 8706296 (more) 8222297 1285360 8931651 15070935 8136620 8389624 8393257 1314144 1963505 8835601 15670199 7704086 8105958 16105961 8304539 19303962 15690314 9558010 9088894 8817725 8582717 7594236 1648460 11085187 8582421 8327371 2168434 9766253 8386590 1314020 2164280 10848884 10751014 16483876 15879359 11148335 12812307 18653285 19998238 1323248
32	IAPP	Islet Amyloid Polypeptide	Protein Coding	23.24	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16492545 1787825 16492543 (more) 8772580 16629719 12534323 10866048 9212322
33	HADHA	Hydroxyacyl-CoA Dehydrogenase Trifunctional Multienzyme Complex Subunit Alpha	Protein Coding	23.17	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders (show sections)	7846063 17143551 10638050 (more) 10352164 2044590 16163656 9403664 15845636 18408953
34	IGFBP3	Insulin Like Growth Factor Binding Protein 3	Protein Coding	23.08	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9849819 1376980 8772589 (more) 7545698 16449027 11956148 16610982 1716259 1697608 16682842 16548790 7476318 9496559 11549873 7512681 7525121 8760024 9876347
35	SLC22A5	Solute Carrier Family 22 Member 5	Protein Coding	22.75	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Summaries (show sections)
36	GH1	Growth Hormone 1	Protein Coding	22.73	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	2108186 8772589 17201814 (more) 16886962 18248651 15644398 1697608 8119670 12531744 8300052 8077335 9851789 16254436 15799216 10155148 1874023 15579776 15163333 8787278 1617799 1902484 10435054 9702443 9329386 1646698 9046989 9076339 18407098 15473884 7962328 11701703 8300055 11167924 15251557 12812307
37	HMGCL	3-Hydroxy-3-Methylglutaryl-CoA Lyase	Protein Coding	22.56	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders (show sections)	8440722 2225463 19932602 (more) 8617516 7479590
38	PCK1	Phosphoenolpyruvate Carboxykinase 1	Protein Coding	22.41	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
39	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	22.14	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
40	PRL	Prolactin	Protein Coding	22.01	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	2194712 8931651 15670199 (more) 16855141 15319231 1864316 1788200 1889145 1369592 15570644 9972958 1314144 7711161 9766253 1843276 8653553 2108186 9736324 1490658 1477030 9578730 8372228 1799919 2168246 2116947 1580163 15708916 11505813 7594236 2047520 2404119 18224292 16396292 9294311 8415342 10335725 7823001 1804282 1936698 9736325 1683502 8706296 1502422 1819787 10518402 15080780 2172669
41	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	21.95	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Functions (show sections)
42	PYGL	Glycogen Phosphorylase L	Protein Coding	21.92	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Summaries (show sections)
43	SLC37A4	Solute Carrier Family 37 Member 4	Protein Coding	21.59	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders (show sections)	17354259 17478431
44	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	21.54	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
45	SLC2A2	Solute Carrier Family 2 Member 2	Protein Coding	20.76	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11810292
46	IGFBP1	Insulin Like Growth Factor Binding Protein 1	Protein Coding	20.52	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9851789 9290603 7523002 (more) 7687525 10207508 10459565 11549873 1280390 10523001
47	MAFA	MAF BZIP Transcription Factor A	Protein Coding	20.25	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
48	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	20.07	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11080093 15793232 10070142 (more) 19515520 10441480
49	GHRL	Ghrelin And Obestatin Prepropeptide	Protein Coding	19.77	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12531744 17201814 16886962 (more) 12351426 15473884 16669599 15163333 15644398 15491786 19636202 16254436 12663236
50	IGFBP2	Insulin Like Growth Factor Binding Protein 2	Protein Coding	19.63	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	1697608 8772589 12161524

Sources

Variations for Hypoglycemia

ClinVar genetic disease variations for Hypoglycemia:

⁵ (show all 11)

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	KCNJ11	NM_000525.4(KCNJ11):c.617G>T (p.Arg206Leu)	SNV	Likely Risk Allele	556175	rs1554901747	GRCh37: 11:17409022-17409022 GRCh38: 11:17387475-17387475
2	KCNJ11	NM_000525.4(KCNJ11):c.466G>A (p.Gly156Arg)	SNV	Likely Risk Allele	8684	rs1404429785	GRCh37: 11:17409173-17409173 GRCh38: 11:17387626-17387626
3	G6PC1	NM_000151.4(G6PC1):c.247C>T (p.Arg83Cys)	SNV	Pathogenic	11998	rs1801175	GRCh37: 17:41055964-41055964 GRCh38: 17:42903947-42903947
4	ABCC8	NM_000352.6(ABCC8):c.3753+1G>A	SNV	Pathogenic	552226	rs1554906786	GRCh37: 11:17419885-17419885 GRCh38: 11:17398338-17398338
5	ABCC8	NM_000352.6(ABCC8):c.3517G>A (p.Val1173Met)	SNV	Likely Pathogenic	35609	rs141322087	GRCh37: 11:17426099-17426099 GRCh38: 11:17404552-17404552
6	ABCC8	NM_000352.6(ABCC8):c.1793G>A (p.Arg598Gln)	SNV	Likely Pathogenic	523361	rs1344172059	GRCh37: 11:17452385-17452385 GRCh38: 11:17430838-17430838
7	ABCC8	NM_000352.6(ABCC8):c.1024G>T (p.Gly342Trp)	SNV	Likely Pathogenic	523360	rs763028380	GRCh37: 11:17474818-17474818 GRCh38: 11:17453271-17453271
8	KCNJ11	NM_000525.4(KCNJ11):c.185C>G (p.Thr62Arg)	SNV	Likely Pathogenic	373928	rs1057518775	GRCh37: 11:17409454-17409454 GRCh38: 11:17387907-17387907
9	MYOM1	NM_003803.4(MYOM1):c.3260G>A (p.Trp1087Ter)	SNV	Likely Pathogenic	804425	rs374670754	GRCh37: 18:3116372-3116372 GRCh38: 18:3116374-3116374
10	MYO7A	NM_000260.4(MYO7A):c.3833C>T (p.Thr1278Ile)	SNV	Uncertain Significance	1683776		GRCh37: 11:76901824-76901824 GRCh38: 11:77190779-77190779
11	SCN1A-AS1, SCN9A	NM_001365536.1(SCN9A):c.1997A>G (p.Lys666Arg)	SNV	Uncertain Significance	6367	rs121908919	GRCh37: 2:167138296-167138296 GRCh38: 2:166281786-166281786

Sources

Expression for Hypoglycemia

Search GEO for disease gene expression data for Hypoglycemia.

Sources

Pathways for Hypoglycemia

Pathways directly related to Hypoglycemia:

#	Pathway	Source
1	Defective ABCC8 can cause hypo- and hyper-glycemias	Reactome ⁶⁶

Pathways related to Hypoglycemia according to GeneCards Suite gene sharing:

(show all 22)

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism ⁶⁶ Show member pathways Metabolism of lipids ⁶⁶	13.34	SLC25A20 SLC16A1 KCNJ11 INS HADH GYS2
2	PI3K-Akt signaling pathway ⁷⁴ Show member pathways Focal adhesion: PI3K-Akt-mTOR-signaling pathway ⁷⁴	12.79	INSR INS IGF2 GYS2 G6PC1
3	Glycosaminoglycan metabolism ⁶⁶ Show member pathways chondroitin sulfate biosynthesis (late stages) ⁶¹ Defective HEXA causes GM2G1 ⁶⁶ Defective HEXB causes GM2G2 ⁶⁶ Glycosaminoglycan degradation ⁷⁴ Heparan sulfate/heparin (HS-GAG) metabolism ⁶⁶ HS-GAG biosynthesis ⁶⁶ Hyaluronan biosynthesis and export ⁶⁶ Hyaluronan metabolism ⁶⁶ Hyaluronan uptake and degradation ⁶⁶ Metabolism of carbohydrates ⁶⁶ MPS I - Hurler syndrome ⁶⁶ MPS II - Hunter syndrome ⁶⁶ MPS IIIA - Sanfilippo syndrome A ⁶⁶ MPS IIIB - Sanfilippo syndrome B ⁶⁶ MPS IIIC - Sanfilippo syndrome C ⁶⁶ MPS IIID - Sanfilippo syndrome D ⁶⁶ MPS IV - Morquio syndrome A ⁶⁶ MPS IX - Natowicz syndrome ⁶⁶ MPS VI - Maroteaux-Lamy syndrome ⁶⁶ MPS VII - Sly syndrome ⁶⁶ Mucopolysaccharidoses ⁶⁶	12.72	GYS2 GCK G6PC1 FBP1 AGL
4	Fatty acid metabolism ⁶⁶ Show member pathways Amodiaquine Pathway, Pharmacokinetics ⁶⁰ Arachidonic acid metabolism ⁶⁶ C20 prostanoid biosynthesis ⁶¹ Carnitine metabolism ⁶⁶ Defective CYP1B1 causes Glaucoma ⁶⁶ Defective CYP2U1 causes SPG56 ⁶⁶ Eicosanoid metabolism via lipooxygenases (LOX) ⁷⁴ fatty acid �-oxidation ⁶¹ fatty acid �-oxidation (peroxisome) ⁶¹ fatty acid �-oxidation (unsaturated, odd number) ⁶¹ fatty acid �-oxidation I ⁶¹ fatty acid �-oxidation III (unsaturated, odd number) ⁶¹ fatty acid �-oxidation VI (peroxisome) ⁶¹ leukotriene biosynthesis ⁶¹ Leukotriene metabolic pathway ⁷⁴ Metabolism of alpha-linolenic acid ⁷⁴ Mitochondrial long chain fatty acid beta-oxidation ⁷⁴ Omega-3 / omega-6 fatty acid synthesis ⁷⁴ Omega-9 fatty acid synthesis ⁷⁴ sphingosine and sphingosine-1-phosphate metabolism ⁶¹ stearate biosynthesis ⁶¹ stearate biosynthesis I (animals and fungi) ⁶¹ Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) ⁶⁶ Synthesis of 12-eicosatetraenoic acid derivatives ⁶⁶ Synthesis of 15-eicosatetraenoic acid derivatives ⁶⁶ Synthesis of 5-eicosatetraenoic acids ⁶⁶ Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) ⁶⁶ Synthesis of Leukotrienes (LT) and Eoxins (EX) ⁶⁶ Synthesis of Prostaglandins (PG) and Thromboxanes (TX) ⁶⁶	12.64	SLC25A20 HADH CPT1A ACADVL ACADM ACADL
5	Angiopoietin-like protein 8 regulatory pathway ⁷⁴ Show member pathways Insulin signaling ⁷⁴ Liver X receptor pathway ⁷⁴	12.36	INSR GYS2 G6PC1 FBP1
6	Integration of energy metabolism ⁶⁶ Show member pathways Acetylcholine regulates insulin secretion ⁶⁶ AMPK inhibits chREBP transcriptional activation activity ⁶⁶ ChREBP activates metabolic gene expression ⁶⁶ Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion ⁶⁶ Free fatty acids regulate insulin secretion ⁶⁶ Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ⁶⁶ Intracellular metabolism of fatty acids regulates insulin secretion ⁶⁶ PKA-mediated phosphorylation of key metabolic factors ⁶⁶ PP2A-mediated dephosphorylation of key metabolic factors ⁶⁶ Regulation of insulin secretion ⁶⁶ Saturated fatty acid biosynthesis ²²	12.33	KCNJ11 INS GCG ABCC8
7	Glucose / Energy Metabolism ³	12.33	INSR INS GLUD1 GCG FBP1 CPT1A
8	Disorders of transmembrane transporters ⁶⁶ Show member pathways SLC transporter disorders ⁶⁶	12.28	SLC16A1 KCNJ11 GCK ABCC8
9	AMPK Enzyme Complex Pathway ⁶⁴ Show member pathways Chromatin Remodeling ⁶⁴	12.03	INSR INS GYS2 CPT1A
10	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	12	GCK G6PC1 CPT1A ACADM
11	AMP-activated protein kinase signaling ⁷⁴ Show member pathways AMPK Signaling Pathway ⁶⁷ Leptin and adiponectin ⁷⁴	11.94	INSR INS GYS2 CPT1A
12	Hepatic ABC Transporters ⁶⁴ Show member pathways MODY (Maturity-Onset Diabetes of Young) ⁶⁴	11.87	INSR INS GCK
13	Thermogenesis ⁷⁴ Show member pathways mitochondrial L-carnitine shuttle ⁶¹	11.82	SLC25A20 GCG CPT1A
14	Amino acid metabolism ⁷⁴ Show member pathways Amino acid metabolism pathway excerpt: histidine catabolism extension ⁷⁴	11.71	ACADM GLUD1 HADH
15	Mitochondrial Fatty Acid Beta-Oxidation ⁶⁶ Show member pathways Beta oxidation of butanoyl-CoA to acetyl-CoA ⁶⁶ Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA ⁶⁶ Beta oxidation of hexanoyl-CoA to butanoyl-CoA ⁶⁶ Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA ⁶⁶ Beta oxidation of myristoyl-CoA to lauroyl-CoA ⁶⁶ Beta oxidation of octanoyl-CoA to hexanoyl-CoA ⁶⁶ Beta oxidation of palmitoyl-CoA to myristoyl-CoA ⁶⁶ mitochondrial fatty acid beta-oxidation of saturated fatty acids ⁶⁶ Propionyl-CoA catabolism ⁶⁶	11.66	ACADL ACADM ACADVL HADH
16	PPAR signaling pathway ⁷⁴ Show member pathways FABP4 in ovarian cancer ⁷⁴ Fatty acid transporters ⁷⁴	11.64	CPT1A ACADM ACADL
17	Development_Leptin signaling via PI3K-dependent pathway ²²	11.42	KCNJ11 GYS2 CPT1A ABCC8
18	Fatty acid beta-oxidation ⁷⁴ Show member pathways mitochondrial fatty acid beta-oxidation of unsaturated fatty acids ⁶⁶	11.23	ACADL ACADM ACADVL CPT1A HADH SLC25A20
19	Galactose metabolism ²² Show member pathways Glycogen metabolism ²²	11.17	GYS2 GCK G6PC1 AGL
20	Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics ⁶⁰	11.1	KCNJ11 INSR INS GCK ABCC8
21	Insulin-mediated glucose transport ⁶¹	10.88	INSR INS
22	FOXA2 and FOXA3 transcription factor networks ⁶¹ Show member pathways FOXA transcription factor networks ⁶¹	10.86	KCNJ11 INS HADH GCK G6PC1 ACADVL

Sources

GO Terms for Hypoglycemia

Cellular components related to Hypoglycemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrion	GO:0005739	9.91	SLC25A20 HADH GLUD1 GCK CPT1A ACADVL
2	inward rectifying potassium channel	GO:0008282	8.92	KCNJ11 ABCC8

Biological processes related to Hypoglycemia according to GeneCards Suite gene sharing:

(show all 24)

#	Name	GO ID	Score	Top Affiliating Genes
1	lipid metabolic process	GO:0006629	10.11	ACADL ACADM ACADVL CPT1A HADH SLC16A1
2	insulin receptor signaling pathway	GO:0008286	10.09	INSR INS IGF2
3	fatty acid beta-oxidation	GO:0006635	10.03	HADH CPT1A ACADM
4	gluconeogenesis	GO:0006094	10.02	GCG G6PC1 FBP1
5	negative regulation of insulin secretion	GO:0046676	9.99	KCNJ11 HADH ABCC8
6	glucose metabolic process	GO:0006006	9.96	CPT1A GCK IGF2 INS KCNJ11
7	positive regulation of mitotic nuclear division	GO:0045840	9.95	IGF2 INS INSR
8	glucose homeostasis	GO:0042593	9.93	SLC16A1 INSR INS GCK GCG G6PC1
9	glucose 6-phosphate metabolic process	GO:0051156	9.91	GCK G6PC1
10	glycogen catabolic process	GO:0005980	9.91	G6PC1 AGL
11	glycogen biosynthetic process	GO:0005978	9.91	GYS2 AGL ACADM
12	negative regulation of fatty acid oxidation	GO:0046322	9.9	ACADVL ACADL
13	positive regulation of respiratory burst	GO:0060267	9.88	INSR INS
14	exocrine pancreas development	GO:0031017	9.88	INSR IGF2
15	fatty acid metabolic process	GO:0006631	9.88	HADH CPT1A ACADVL ACADM ACADL
16	carbohydrate metabolic process	GO:0005975	9.87	INSR INS IGF2 GCK FBP1 AGL
17	fatty acid beta-oxidation using acyl-CoA dehydrogenase	GO:0033539	9.85	ACADVL ACADM ACADL
18	carnitine shuttle	GO:0006853	9.84	SLC25A20 CPT1A
19	metabolic process	GO:0008152	9.83	GYS2 GCK FBP1 AGL
20	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO:0035774	9.8	ABCC8 GCG KCNJ11
21	carnitine metabolic process	GO:0009437	9.77	CPT1A ACADM
22	carnitine metabolic process, CoA-linked	GO:0019254	9.76	ACADM ACADL
23	positive regulation of glycogen biosynthetic process	GO:0045725	9.56	INSR INS IGF2 GCK
24	regulation of insulin secretion	GO:0050796	9.4	SLC16A1 KCNJ11 HADH GCK GCG CPT1A

Molecular functions related to Hypoglycemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	10.37	ACADL ACADM ACADVL CPT1A FBP1 GCG
2	flavin adenine dinucleotide binding	GO:0050660	9.91	ACADVL ACADM ACADL
3	hormone activity	GO:0005179	9.86	INS IGF2 GCG CRH
4	ATP-activated inward rectifier potassium channel activity	GO:0015272	9.71	KCNJ11 ABCC8
5	long-chain-acyl-CoA dehydrogenase activity	GO:0004466	9.62	ACADVL ACADL
6	insulin-like growth factor receptor binding	GO:0005159	9.43	INSR INS IGF2
7	oxidoreductase activity, acting on the CH-CH group of donors	GO:0016627	9.33	ACADVL ACADM ACADL
8	acyl-CoA dehydrogenase activity	GO:0003995	9.1	ACADVL ACADM ACADL