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MCID: HYP056
MIFTS: 62

Hypoglycemia

Categories: Endocrine diseases, Metabolic diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Hypoglycemia

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MalaCards integrated aliases for Hypoglycemia:

Name: Hypoglycemia 12 76 29 55 6 43 44 15 73
Hypoglycaemia 12

Classifications:

MalaCards categories:
Global: Metabolic diseases
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:9993
ICD10 33 E16.2
ICD9CM 35 251.2
MeSH 44 D007003
NCIt 50 C3126
UMLS 73 C0020615
Sources

Summaries for Hypoglycemia

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MedlinePlus : 43 Hypoglycemia means low blood glucose, or blood sugar. Your body needs glucose to have enough energy. After you eat, your blood absorbs glucose. If you eat more sugar than your body needs, your muscles, and liver store the extra. When your blood sugar begins to fall, a hormone tells your liver to release glucose. In most people, this raises blood sugar. If it doesn't, you have hypoglycemia, and your blood sugar can be dangerously low. Signs include Hunger Shakiness Dizziness Confusion Difficulty speaking Feeling anxious or weak In people with diabetes, hypoglycemia is often a side effect of diabetes medicines. Eating or drinking something with carbohydrates can help. If it happens often, your health care provider may need to change your treatment plan. You can also have low blood sugar without having diabetes. Causes include certain medicines or diseases, hormone or enzyme deficiencies, and tumors. Laboratory tests can help find the cause. The kind of treatment depends on why you have low blood sugar. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Hypoglycemia, also known as hypoglycaemia, is related to hyperinsulinemic hypoglycemia, familial, 2 and insulin autoimmune syndrome, and has symptoms including sugar craving An important gene associated with Hypoglycemia is G6PC (Glucose-6-Phosphatase Catalytic Subunit), and among its related pathways/superpathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs Zinc and Exenatide have been mentioned in the context of this disorder. Affiliated tissues include pancreas, testes and liver, and related phenotypes are shRNA abundance <= 50% and homeostasis/metabolism

Wikipedia : 76 Hypoglycemia, also known as low blood sugar, is when blood sugar decreases to below normal levels. This... more...

Sources

Related Diseases for Hypoglycemia

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Diseases related to Hypoglycemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 414)
# Related Disease Score Top Affiliating Genes
1 hyperinsulinemic hypoglycemia, familial, 2 34.6 ABCC8 INS KCNJ11
2 insulin autoimmune syndrome 33.4 INS INSR
3 fasting hypoglycemia 32.7 ACADM CRH GLUD1 GYS2 INSR
4 hyperinsulinemic hypoglycemia 32.5 ABCC8 GCK GLUD1 HADH INS INSR
5 glycogen storage disease type 0 32.2 AGL GYS2
6 epiphyseal dysplasia, multiple, with early-onset diabetes mellitus 32.1 ABCC8 KCNJ11
7 fructose-1,6-bisphosphatase deficiency 31.5 AGL FBP1 G6PC GCG
8 glycogen storage disease iii 31.5 AGL G6PC GCG
9 hyperinsulinism 31.2 ABCC8 GCK GLUD1 HADH INS INSR
10 carnitine-acylcarnitine translocase deficiency 31.1 CPT1A CPT2 SLC25A20
11 long-chain 3-hydroxyacyl-coa dehydrogenase deficiency 31.1 ACADM ACADVL HADH
12 insulinoma 31.0 ABCC8 GCG GCK INS
13 carnitine deficiency, systemic primary 30.8 ACADVL CPT2 SLC25A20
14 carnitine palmitoyltransferase ii deficiency, infantile 30.7 ACADVL CPT1A CPT2 SLC25A20
15 acyl-coa dehydrogenase, very long-chain, deficiency of 30.5 ACADVL CPT2 HADH SLC25A20
16 insulin-like growth factor i 30.2 AKT2 INS INSR
17 maturity-onset diabetes of the young 30.0 ABCC8 GCG GCK INS KCNJ11
18 diabetes mellitus 29.9 ABCC8 AKT2 GCG GCK INS INSR
19 monogenic diabetes 29.9 ABCC8 GCK INS KCNJ11
20 3-hydroxyacyl-coa dehydrogenase deficiency 29.9 ACADM ACADVL GCK GLUD1 HADH INS
21 gestational diabetes 29.9 GCK INS INSR KCNJ11
22 hyperglycemia 29.6 ABCC8 G6PC GCG GCK INS INSR
23 glucose intolerance 29.6 GCG GCK INS INSR
24 sheehan syndrome 28.9 CRH INS
25 diabetes mellitus, noninsulin-dependent 28.8 ABCC8 AKT2 G6PC GCG GCK INS
26 hyperinsulinemic hypoglycemia, familial, 1 12.5
27 hypoglycemia, leucine-induced 12.4
28 hyperinsulinemic hypoglycemia, familial, 7 12.4
29 hyperinsulinemic hypoglycemia, familial, 5 12.4
30 hyperinsulinemic hypoglycemia, familial, 3 12.3
31 hyperinsulinemic hypoglycemia, familial, 4 12.3
32 hyperinsulinemic hypoglycemia, familial, 6 12.3
33 hypoinsulinemic hypoglycemia with hemihypertrophy 12.2
34 hypoketonemic hypoglycemia 11.9
35 adult-onset non-insulinoma persistent hyperinsulinemic hypoglycemia 11.8
36 glycogen storage disease 0, liver 11.8
37 glycogen storage disease ia 11.2
38 beckwith-wiedemann syndrome 11.1
39 fructose intolerance, hereditary 11.0
40 carnitine palmitoyltransferase i deficiency 11.0
41 insulinomatosis and diabetes mellitus 11.0
42 mitochondrial dna depletion syndrome 4a 11.0
43 galactosemia 11.0
44 achalasia-addisonianism-alacrima syndrome 11.0
45 congenital disorder of glycosylation, type in 11.0
46 mitochondrial complex iii deficiency 11.0
47 pepck 1 deficiency 11.0
48 brittle diabetes 10.9
49 carnitine palmitoyltransferase i deficiency , muscle 10.9
50 3-hydroxy-3-methylglutaryl-coa lyase deficiency 10.9

Comorbidity relations with Hypoglycemia via Phenotypic Disease Network (PDN): (show all 33)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alzheimer Disease
Benign Essential Hypertension Bronchitis
Cerebral Atherosclerosis Chronic Kidney Failure
Chronic Myocardial Ischemia Decubitus Ulcer
Deficiency Anemia Diabetic Polyneuropathy
Encephalopathy Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Hypoglycemic Coma Hypothyroidism
Intermediate Coronary Syndrome Iron Deficiency Anemia
Ischemic Heart Disease Kidney Disease
Microvascular Complications of Diabetes 1 Microvascular Complications of Diabetes 7
Mitral Valve Disease Peripheral Vascular Disease
Protein-Energy Malnutrition Respiratory Failure
Schizophreniform Disorder Sinoatrial Node Disease
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Hypoglycemia:



Diseases related to Hypoglycemia
Sources

Symptoms & Phenotypes for Hypoglycemia

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UMLS symptoms related to Hypoglycemia:


sugar craving

GenomeRNAi Phenotypes related to Hypoglycemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 9.32 ACADM ACADVL AGL CPT2 FBP1 G6PC

MGI Mouse Phenotypes related to Hypoglycemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 KCNJ11 SLC16A1 INS SLC25A20 INSR GLUD1
2 growth/size/body region MP:0005378 10.11 INSR KCNJ11 HADH SLC16A1 INS GLUD1
3 endocrine/exocrine gland MP:0005379 10.1 INSR KCNJ11 HADH INS SLC25A20 GLUD1
4 cardiovascular system MP:0005385 10.09 INSR KCNJ11 SLC25A20 INS GYS2 CPT1A
5 adipose tissue MP:0005375 10.06 INSR KCNJ11 HADH SLC16A1 INS AKT2
6 liver/biliary system MP:0005370 10.03 INSR SLC16A1 INS SLC25A20 AKT2 GYS2
7 mortality/aging MP:0010768 9.97 INSR KCNJ11 SLC16A1 SLC25A20 INS AKT2
8 muscle MP:0005369 9.56 INSR KCNJ11 INS AKT2 GYS2 ACADM
9 renal/urinary system MP:0005367 9.17 INSR HADH SLC25A20 INS CRH G6PC
Sources

Drugs & Therapeutics for Hypoglycemia

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Drugs for Hypoglycemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 580)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7440-66-6 23994
2
Exenatide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 141758-74-9 15991534
3
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 111025-46-8 4829
4
Menthol Approved Phase 4,Phase 3,Phase 2,Not Applicable 2216-51-5 16666
5
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 657-24-9 14219 4091
6
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-23-7 5754
7
Vildagliptin Approved, Investigational Phase 4,Phase 3 274901-16-5 6918537
8
Ezetimibe Approved Phase 4 163222-33-1 150311
9
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9005-49-6 772 46507594
10
Gliclazide Approved Phase 4,Phase 3,Phase 2,Not Applicable 21187-98-4 3475
11
Repaglinide Approved, Investigational Phase 4,Phase 3,Phase 2 135062-02-1 65981
12
Diazoxide Approved Phase 4,Phase 2,Phase 3,Phase 1 364-98-7 3019
13
Liraglutide Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 204656-20-2 44147092
14
Saxagliptin Approved Phase 4,Phase 3,Phase 2,Phase 1 361442-04-8 11243969
15
Pramlintide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 151126-32-8
16
Octreotide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83150-76-9 383414 6400441
17
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 1994-09-7, 94-09-7 2337
18 lanreotide Approved Phase 4 108736-35-2
19
Ethanol Approved Phase 4,Phase 2,Phase 1,Not Applicable 64-17-5 702
20
Glipizide Approved, Investigational Phase 4,Phase 3,Not Applicable 29094-61-9 3478
21
Acarbose Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 56180-94-0 441184
22
Glyburide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 10238-21-8 3488
23
Glimepiride Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 93479-97-1 3476
24
Insulin Aspart Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 116094-23-6 16132418
25
Insulin Glargine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 160337-95-1
26
Insulin glulisine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 207748-29-6
27
Insulin Detemir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 169148-63-4 5311023
28
Insulin Lispro Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 133107-64-9
29
Pancrelipase Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 53608-75-6
30
Somatostatin Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 38916-34-6, 51110-01-1 53481605
31
Simvastatin Approved Phase 4,Phase 3 79902-63-9 54454
32
Verapamil Approved Phase 4 52-53-9 2520
33
Doxazosin Approved Phase 4 74191-85-8 3157
34
Aprepitant Approved, Investigational Phase 4 170729-80-3 151165 6918365
35
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-61-6, 62-31-7 681
36
Nateglinide Approved, Investigational Phase 4 105816-04-4 60026
37
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 185243-69-0
38
Phenoxybenzamine Approved Phase 4 59-96-1 4768
39
Rosiglitazone Approved, Investigational Phase 4,Phase 3,Phase 2 122320-73-4 77999
40
Entecavir Approved, Investigational Phase 4,Phase 3,Phase 2 142217-69-4 153941
41
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Not Applicable,Early Phase 1 51-43-4 5816
42
Canagliflozin Approved Phase 4,Phase 3,Phase 2,Phase 1 842133-18-0
43
Fosaprepitant Approved Phase 4 172673-20-0 219090
44
Gliquidone Approved, Investigational Phase 4 33342-05-1 91610
45
Alogliptin Approved Phase 4,Phase 3,Phase 2 850649-61-5 11450633
46
Linagliptin Approved Phase 4,Phase 3,Not Applicable 668270-12-0 10096344
47
Prednisone Approved, Vet_approved Phase 4,Phase 1,Phase 2,Early Phase 1 53-03-2 5865
48
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 2 93-14-1 3516
49
Racepinephrine Approved Phase 4,Phase 2,Not Applicable,Early Phase 1 329-65-7 838
50
Labetalol Approved Phase 4,Phase 2,Phase 3 36894-69-6 3869

Interventional clinical trials:

(show top 50) (show all 2151)
# Name Status NCT ID Phase Drugs
1 Lactate and Hypoglycemia Unknown status NCT01387477 Phase 4 Lactate;Glucose
2 Use of Diazoxide in Acute Hypoglycaemia Unknown status NCT01488136 Phase 4 Diazoxide;Placebo
3 Glucose Control During Labour in Gestational Diabetes Mellitus With Insulin Treatment: A Randomized Controlled Trial Unknown status NCT02590016 Phase 4 Insulin, Aspart
4 Do Sulphonylureas Preserve Cortical Function During Hypoglycaemia? Unknown status NCT00472875 Phase 4 Glibenclamide
5 Treatment of Low Blood Sugar With Glucagon Among Patients With Type 1 Diabetes Unknown status NCT02232971 Phase 4 Glucagon
6 Outpatient Discharge Therapy With Saxagliptin+MetforminXR vs GlipizideXL for Type 2 Diabetes With Severe Hyperglycemia Unknown status NCT01267448 Phase 4 Glipizide XL;Saxagliptin + Metformin XR;Metformin XR
7 Glucometer and Mobile-phone Based Data Transfer System in Diabetes Unknown status NCT02769377 Phase 4
8 Comparing Long-acting Insulins During Exercise in Type 1 Diabetes Unknown status NCT01440439 Phase 4 Insulin glargine;Insulin detemir
9 Real-Time Continuous Glucose Monitoring in Pre-School Children With Type-1 Diabetes Mellitus Unknown status NCT01016457 Phase 4
10 Intensive Insulin Therapy for Strict Glycemic Control in Neurosurgical Patients: Safety and Efficacy Unknown status NCT00505505 Phase 4 Insulin (Actrapid)
11 Lanreotide Autogel Treatment of Patients With Congenital Hyperinsulinism of Infancy Unknown status NCT01070758 Phase 4 Lanreotide autogel
12 Metformin and Sitagliptin Therapy for Adult Patients With Type 2 Diabetes Admitted to the General Medical Unit Unknown status NCT02250794 Phase 4 metformin and sitagliptin;insulin glargine and insulin lispro;metformin and sitagliptin;insulin glargine and insulin lispro
13 Long-Term Sulfonylurea Response in ABCC8 Neonatal Diabetes (SuResponsSUR) Unknown status NCT02624830 Phase 4 Sulfonylurea
14 Obtain a Good Blood Glucose Control With the Paradigm Real Time System Unknown status NCT00441129 Phase 4
15 Substitution of First Phase Insulin Response in Patient With Type 2 Diabetes. Unknown status NCT00254085 Phase 4 Insulin Aspart
16 Saxagliptin's Effects on Microalbuminuria Improvement in Type 2 Diabetic Patients Unknown status NCT02462369 Phase 4 Saxagliptin;glimepiride
17 Effect of an Artificial Pancreas in Patients Undergoing Pancreatic Resection Unknown status NCT00661648 Phase 4
18 Endobarrier Treatment in Obese Subjects With T2DM Unknown status NCT01718457 Phase 4
19 GLP-1 Analogue Treatment in Uncontrolled Type 1 Diabetic Patients Unknown status NCT01592279 Phase 4 liraglutide;Insulin injections
20 Comparison of Exenatide vs. Biphasic Insulin Aspart 30 on Glucose Variability in Type 2 Diabetes Unknown status NCT02449603 Phase 4 Exenatide;Biphasic insulin Aspart 30
21 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics Unknown status NCT00845936 Phase 4 Metformin
22 CONSISTENT 1: Metabolic and Safety Outcomes of Hylenex Recombinant (Hyaluronidase Human Injection) Preadministered at CSII Infusion Site in Participants With Type 1 Diabetes Mellitus (T1DM) Unknown status NCT01848990 Phase 4 Commercial Hylenex® recombinant (hyaluronidase human injection);Precommercial Hylenex recombinant (hyaluronidase human injection);Insulin lispro;Insulin aspart;Insulin glulisine
23 Organization Program of DiabEtes INsulIN ManaGement Unknown status NCT01338376 Phase 4 Scilin®M30
24 A Double-Blind, Randomized, Parallel, Comparative Study to Evaluate the Efficacy and Safety of an Antidiabetic Agent Repaglinide for the Treatment of Type 2 Diabetes Mellitus Patients Unknown status NCT00336310 Phase 4 Repaglinide
25 Randomized Trial Comparing Colesevelam vs. Ezetimibe Unknown status NCT02682680 Phase 4 Colesevelam;Ezetimibe
26 Compare the Effect of DPP-IV Inhibitor or TZD on Glycemic Variability and Oxidative Stress in Patient With 2 Diabetes Unknown status NCT01339143 Phase 4 Galvus (vildagliptin);pioglitazone
27 Exploratory Study to Compare the Effects of Tenelia® or Januvia® on Glucose Variability in add-on to Metformin (CGMS Study) Unknown status NCT02512523 Phase 4 Teneligliptin;Sitagliptin
28 Comparison of Glycaemic Fluctuation and Oxidative Stress Between Two Short-term Therapies for Type 2 Diabetes Unknown status NCT02526810 Phase 4 insulin lispro;Insulin Glargine
29 Comparison Study of Insulin Glargine and NPH Insulin Unknown status NCT01854723 Phase 4 Switching to NPH insulin;Continuation of insulin glargine
30 Continuous Subcutaneous Insulin Infusion strAtegy Versus Multiple Daily Insulin Injections strAtegy Unknown status NCT01574508 Phase 4 Transient Continuous Subcutaneous Insulin Infusion;Transient Multiple Daily Insulin Injections
31 Insulin NovoRapid Versus Actrapid in Treatment of Type 1 Diabetic Patients During Daily Adjustment of Insulin Dose Unknown status NCT00145353 Phase 4 Insulin NovoRapid versus Actrapid
32 Oral Antidiabetic Agents in Pregnancy Unknown status NCT02091336 Phase 4 Metformin;Glyburide
33 Syringes Replacement for Insulin Application for Pens Device in a Population of Elderly Patients With Type 2 Diabetes: Multifactorial Intervention to Improve Glycemic Control Unknown status NCT02517242 Phase 4
34 Effect on Beta Cell Function and Glycaemic Control After Insulin and Exenatide Sequential Therapy Unknown status NCT02129985 Phase 4 Exenatide;Metformin
35 Clinical Study to Compare Various Dosing and Titration Guidelines of Insulin Delivered Via V-Go ® in Patients With Type 2 Diabetes Initiating Basal Bolus Therapy in Primary Care Offices Unknown status NCT02361489 Phase 4
36 Comparison of Premixed Insulin With Basal-plus Insulin in Type 2 Diabetes Patients Unknown status NCT02219750 Phase 4 switch twice-daily insulin
37 Comparison of Two Titration Programs of Adding Insulin Detemir to OADs in Poorly Controlled Type 2 Diabetes Unknown status NCT01281605 Phase 4
38 Effect of SGLT-2 Inhibitor Dapagliflozin on Glycemic Variability in Patients With Diabetes Mellitus Type 2 Unknown status NCT02719756 Phase 4 Metformin;Dapagliflozin;Metformin up-titration
39 Human Insulin Analogs: Evaluation of Inflammatory mRNA Expression of Macrophages and Endothelial Function of Short-acting Insulin - HERMES Pilot Study Unknown status NCT01417897 Phase 4 Insulin glulisine;Insulin aspart;Regular human insulin
40 The Therapeutic Effects of Insulin and Berberine on Stress Hyperglycemia Unknown status NCT02806999 Phase 4 Berberine; Insulin;Insulin
41 Study on Lixisenatide and Counterregulation to Hypoglycemia Completed NCT02020629 Phase 4 Lixisenatide
42 Vildagliptin and the Glucagon Response to Hypoglycemia in Insulin-Treated Patients With Type 2 Diabetes Completed NCT01219400 Phase 4 Vildagliptin
43 Vildagliptin and the Glucagon Response to Hypoglycemia in Type 1 Diabetes Completed NCT01147276 Phase 4 Vildagliptin
44 Insulin Analogues and Severe Hypoglycaemia Completed NCT00346996 Phase 4 insulin levemir / aspart;human insulin /insulin isophane
45 Treatment With Sitagliptin for Reactive Hypoglycemia Secondary to Dysinsulinism Completed NCT00847080 Phase 4 Sitagliptin phosphate;Placebo
46 Investigating the Accuracy of the Home Glucose Monitors in Hypoglycemia Completed NCT01013402 Phase 4 Human insulin;Human Insulin
47 Treatment of Hypoglycemia Following Gastric Bypass Surgery Completed NCT02527993 Phase 4 Glucobay (acarbose);Januvia (sitagliptin);Verapamil HEXAL (verapamil);Victoza (liraglutide);Signifor (pasireotide)
48 Prevention of Severe Hypoglycemia in Type 1 Diabetes Completed NCT00360984 Phase 4 insulin glargine
49 Continuous Glucose Monitoring and Preterm Infants Completed NCT02583776 Phase 4
50 Sitagliptin and Glucagon Counterregulation Completed NCT02256189 Phase 4 Sitagliptin;Placebo

Search NIH Clinical Center for Hypoglycemia

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: hypoglycemia

Sources

Genetic Tests for Hypoglycemia

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Genetic tests related to Hypoglycemia:

# Genetic test Affiliating Genes
1 Hypoglycemia 29
Sources

Anatomical Context for Hypoglycemia

About this section

MalaCards organs/tissues related to Hypoglycemia:

41
Pancreas, Testes, Liver, Brain, Kidney, Heart, Pancreatic Islet
Sources

Publications for Hypoglycemia

About this section

Articles related to Hypoglycemia:

(show top 50) (show all 1750)
# Title Authors Year
1
Severe fasting hypoglycemia in a child after total pancreatectomy with islet autotransplantation. ( 29139589 )
2018
2
Insulin Detemir Use Is Associated With Higher Occurrence of Hypoglycemia in Hospitalized Patients With Hypoalbuminemia. ( 29437697 )
2018
3
Neonatal hyperinsulinemic hypoglycemia in a patient with 9p deletion syndrome. ( 29601900 )
2018
4
Association of Initiation of Basal Insulin Analogs vs Neutral Protamine Hagedorn Insulin With Hypoglycemia-Related Emergency Department Visits or Hospital Admissions and With Glycemic Control in Patients With Type 2 Diabetes. ( 29936529 )
2018
5
Hypoglycemia, Cardiovascular Outcomes, and Death: The LEADER Experience. ( 29903847 )
2018
6
CORRIGENDUM FOR &amp;quot;Novel Hypoglycemia Phenotype in Congenital Hyperinsulinism Due to Dominant Mutations of Uncoupling Protein 2&amp;quot;. ( 29538671 )
2018
7
Hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients. ( 29301418 )
2018
8
Giant umbilical cord and hypoglycemia in an infant with Proteus syndrome. ( 29681107 )
2018
9
Hypoglycemia in a Patient With a Polyhormonal Pancreatic Neuroendocrine Tumor With Evidence of Endocrine Progenitors. ( 29568813 )
2018
10
Stable Liquid Glucagon: Beyond Emergency Hypoglycemia Rescue. ( 29415555 )
2018
11
Prevalence and predictors of hypoglycemia in South Korea. ( 29939502 )
2018
12
Association of ADHD with recurrent hypoglycemia in type 1 DM. ( 29938875 )
2018
13
Different Indexes of Glycemic Variability as Identifiers of Patients with Risk of Hypoglycemia in Type 2 Diabetes Mellitus. ( 29451006 )
2018
14
A unique allosteric insulin receptor monoclonal antibody that prevents hypoglycemia in the SUR-1<sup>-/-</sup> mouse model of KATP hyperinsulinism. ( 29589989 )
2018
15
A Quality-Improvement Initiative to Reduce NICU Transfers for Neonates at Risk for Hypoglycemia. ( 29437908 )
2018
16
Costello Syndrome: The Challenge of Hypoglycemia and Failure to Thrive. ( 29248509 )
2018
17
Detection of asymptomatic drug-induced hypoglycemia using continuous glucose monitoring in older people - Systematic review. ( 29887300 )
2018
18
Does reactive hypoglycemia during the 100 g oral glucose tolerance test adversely affect perinatal outcomes? ( 29411343 )
2018
19
Severe insulin resistance in disguise: A familial case of reactive hypoglycemia associated with a novel heterozygous INSR mutation. ( 29411486 )
2018
20
Avoiding Hypoglycemia: The use of Insulin Pump combined with Continuous Glucose Monitor in Type 1 Diabetes Crossing a Rocky Gorge. ( 29939323 )
2018
21
Poor Sleep Quality is Associated with Nocturnal Glycemic Variability and Fear of Hypoglycemia in Adults with Type 1 Diabetes. ( 29917259 )
2018
22
Individuals with Type 1 and Type 2 Diabetes Mellitus Trade Increased Hyperglycemia for Decreased Hypoglycemia When Glycemic Variability is not Improved. ( 29164512 )
2018
23
Diazoxide toxicity in a child with persistent hyperinsulinemic hypoglycemia of infancy: mixed hyperglycemic hyperosmolar coma and ketoacidosis. ( 29958183 )
2018
24
No answers yet for the prevention of neonatal hypoglycemia. ( 29936962 )
2018
25
A novel homozygous mutation in the mannose phosphate isomerase gene causing congenital disorder of glycation and hyperinsulinemic hypoglycemia in an infant. ( 29531722 )
2018
26
The Effect of Everolimus on Refractory Hypoglycemia in a Patient with Inoperable Metastatic Insulinoma Evaluated by Continuous Glucose Monitoring. ( 29877259 )
2018
27
Acquired Chiari I Malformation Secondary to Spontaneous Intracranial Hypotension Syndrome and Persistent Hypoglycemia: A Case Report. ( 29513222 )
2018
28
HbA<sub>1c</sub> and Hypoglycemia Reductions at 24 and 52 Weeks With Sotagliflozin in Combination With Insulin in Adults With Type 1 Diabetes: The European inTandem2 Study. ( 29937431 )
2018
29
Quality-of-life and treatment satisfaction in actual clinical practice of patients with Type 1 diabetes mellitus (T1DM) and hypoglycemia treated with insulin degludec. ( 29300101 )
2018
30
Severe hypoglycemia is associated with high risk for falls in adults with type 1 diabetes. ( 29892791 )
2018
31
Hypoglycemia and cognitive function in diabetic patients. ( 29887517 )
2018
32
Intentional overdose of liraglutide in a non-diabetic patient causing severe hypoglycemia. ( 29397808 )
2018
33
Roux en Y gastric bypass hypoglycemia resolves with gastric feeding or reversal: Confirming a non-pancreatic etiology. ( 29449181 )
2018
34
Exposure to hypoglycemia and risk of stroke. ( 29917249 )
2018
35
Recurrent lactic acidosis and hypoglycemia with inadvertent metformin use: a case of look-alike pills. ( 29340159 )
2018
36
A case of CHARGE syndrome associated with hyperinsulinemic hypoglycemia in infancy. ( 29355723 )
2018
37
Severe lactic acidosis and hypoglycemia due to acute metformin intoxication in a dog. ( 29687945 )
2018
38
Reduced Glucose Variability With Glucose-Dependent Versus Glucose-Independent Therapies Despite Similar Glucose Control and Hypoglycemia Rates in a Randomized, Controlled Study of Older Patients With Type 2 Diabetes Mellitus. ( 29893144 )
2018
39
Recurrent non-severe hypoglycemia exacerbates imbalance of mitochondrial homeostasis leading to synapse injury and cognitive deficit in diabetes. ( 29969317 )
2018
40
Agraphia with reversible splenial corpus callosum lesion caused by hypoglycemia. ( 29606344 )
2018
41
Short communication: Cow- and herd-level prevalence of hypoglycemia in hyperketonemic postpartum dairy cows. ( 29428744 )
2018
42
Ketotic Hypoglycemia in Children with Previous Transient Congenital Hyperinsulinism. ( 29503277 )
2018
43
Relationship between Blood Glucose Fluctuation and Brain Damage in the Hypoglycemia Neonates. ( 29444533 )
2018
44
Glial acetate metabolism is increased following a 72-h fast in metabolically healthy men and correlates with susceptibility to hypoglycemia. ( 29931424 )
2018
45
Can reversal of RYGB also reverse hypoglycemia? ( 29371089 )
2018
46
Lower objectively measured physical activity is linked with perceived risk of hypoglycemia in type 1 diabetes. ( 29937138 )
2018
47
Second-Generation Antipsychotic-Induced Hypoglycemia. ( 29372938 )
2018
48
Persistent hypoglycemia associated with lipid storage myopathy in a paint foal. ( 29957835 )
2018
49
Late Onset of Non-islet Cell Tumor Hypoglycemia Managed via Multidisciplinary Treatment in a Patient with a Solitary Fibrous Tumor. ( 29526941 )
2018
50
Hypoglycemia in dogs: Causes, management, and diagnosis. ( 29910479 )
2018
Sources

Variations for Hypoglycemia

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ClinVar genetic disease variations for Hypoglycemia:

6
(show all 11)
# Gene Variation Type Significance SNP ID Assembly Location
1 G6PC NM_000151.3(G6PC): c.247C> T (p.Arg83Cys) single nucleotide variant Pathogenic rs1801175 GRCh37 Chromosome 17, 41055964: 41055964
2 G6PC NM_000151.3(G6PC): c.247C> T (p.Arg83Cys) single nucleotide variant Pathogenic rs1801175 GRCh38 Chromosome 17, 42903947: 42903947
3 ABCC8 NM_000352.4(ABCC8): c.3517G> A (p.Val1173Met) single nucleotide variant Likely pathogenic rs141322087 GRCh37 Chromosome 11, 17426099: 17426099
4 ABCC8 NM_000352.4(ABCC8): c.3517G> A (p.Val1173Met) single nucleotide variant Likely pathogenic rs141322087 GRCh38 Chromosome 11, 17404552: 17404552
5 46;X;t(X;5)(p11.23;q35)dn Translocation Pathogenic
6 KCNJ11 NM_000525.3(KCNJ11): c.185C> G (p.Thr62Arg) single nucleotide variant Likely pathogenic rs1057518775 GRCh38 Chromosome 11, 17387907: 17387907
7 KCNJ11 NM_000525.3(KCNJ11): c.185C> G (p.Thr62Arg) single nucleotide variant Likely pathogenic rs1057518775 GRCh37 Chromosome 11, 17409454: 17409454
8 ABCC8 NM_000352.4(ABCC8): c.1793G> A (p.Arg598Gln) single nucleotide variant Likely pathogenic GRCh38 Chromosome 11, 17430838: 17430838
9 ABCC8 NM_000352.4(ABCC8): c.1793G> A (p.Arg598Gln) single nucleotide variant Likely pathogenic GRCh37 Chromosome 11, 17452385: 17452385
10 ABCC8 NM_000352.4(ABCC8): c.1024G> T (p.Gly342Trp) single nucleotide variant Likely pathogenic rs763028380 GRCh37 Chromosome 11, 17474818: 17474818
11 ABCC8 NM_000352.4(ABCC8): c.1024G> T (p.Gly342Trp) single nucleotide variant Likely pathogenic rs763028380 GRCh38 Chromosome 11, 17453271: 17453271
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Expression for Hypoglycemia

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Search GEO for disease gene expression data for Hypoglycemia.
Sources

Pathways for Hypoglycemia

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Pathways related to Hypoglycemia according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Metabolism 66
Show member pathways
 13.82 ABCC8 ACADM ACADVL AGL CPT1A CPT2
2
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 66
Show member pathways
 13.51 AKT2 CPT1A CPT2 GCG INS INSR
3
Aldosterone synthesis and secretion 37
Show member pathways
 12.95 ABCC8 AKT2 CRH GCG GCK INS
4
Regulation of lipid metabolism Insulin signaling-generic cascades 22
Show member pathways
 12.85 AKT2 FBP1 G6PC GCK GYS2 INS
5
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) 66
Show member pathways
 12.84 ACADM ACADVL CPT1A CPT2 HADH SLC25A20
6
Glycosaminoglycan metabolism 66
Show member pathways
 12.81 AGL FBP1 G6PC GCK GYS2
7
Glucose metabolism 66
Show member pathways
 12.59 AGL FBP1 G6PC GCK GYS2
8
Angiopoietin Like Protein 8 Regulatory Pathway 1
Show member pathways
 12.48 AKT2 FBP1 G6PC GYS2 INS INSR
9
Glucose / Energy Metabolism 4
12.47 AKT2 CPT1A FBP1 GCG GLUD1 INS
10
AMP-activated Protein Kinase (AMPK) Signaling 1
Show member pathways
 12.36 AKT2 CPT1A FBP1 G6PC GYS2 INS
11
Integration of energy metabolism 66
Show member pathways
 12.31 ABCC8 GCG INS KCNJ11
12
Carbon metabolism 37
Show member pathways
 12.25 ACADM FBP1 GCK GLUD1
13
AMPK Enzyme Complex Pathway 64
Show member pathways
 12.17 AKT2 CPT1A CPT2 GYS2 INS INSR
14
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.12 ACADM CPT1A G6PC GCK
15
FoxO signaling pathway 37
Show member pathways
 12.02 AKT2 G6PC INS INSR
16
Galactose metabolism 37 22
Show member pathways
 11.96 AGL G6PC GCK GYS2
17
Hepatic ABC Transporters 64
Show member pathways
 11.95 GCK INS INSR
18
DNA Damage Response (only ATM dependent) 1
11.91 AKT2 G6PC INSR
19
Type II diabetes mellitus 37 1
Show member pathways
 11.87 ABCC8 GCK INS INSR KCNJ11
20
HIF-1 signaling pathway 37
11.84 AKT2 INS INSR
21
Regulation of beta-cell development 66
Show member pathways
 11.84 AKT2 GCK INS
22
Fatty acid metabolism 37
Show member pathways
 11.84 ACADM ACADVL CPT1A CPT2 HADH
23
Insulin resistance 37
Show member pathways
 11.84 AKT2 CPT1A G6PC GYS2 INS INSR
24
Amino Acid metabolism 1
11.79 ACADM GLUD1 HADH
25
PPAR signaling pathway 37
11.67 ACADM CPT1A CPT2
26
Adipocytokine signaling pathway 37
11.65 AKT2 CPT1A G6PC
27
Mitochondrial Fatty Acid Beta-Oxidation 66
Show member pathways
 11.62 ACADM ACADVL HADH
28
Regulation of lipolysis in adipocytes 37
11.53 AKT2 INS INSR
29
Glucagon signaling pathway 37
11.51 AKT2 CPT1A FBP1 G6PC GCG GCK
30
Development_Leptin signaling via PI3K-dependent pathway 22
11.48 ABCC8 AKT2 CPT1A GYS2 KCNJ11
31
Insulin Pathway 1
11.41 AKT2 INS INSR
32
Mitochondrial LC-Fatty Acid Beta-Oxidation 1
Show member pathways
 11.36 ACADM ACADVL CPT1A CPT2 HADH SLC25A20
33
Insulin-mediated glucose transport 1
11.21 AKT2 INS INSR
34
PPAR Alpha Pathway 1
11.15 ACADM CPT1A CPT2
35
FOXA2 and FOXA3 transcription factor networks 1
10.92 ABCC8 ACADM ACADVL CPT1A G6PC GCK
36
Insulin signalling in human adipocytes (diabetic condition) 1
Show member pathways
 10.87 AKT2 INSR
37
Import of palmitoyl-CoA into the mitochondrial matrix 66
10.73 CPT1A CPT2 SLC25A20
38
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 66
Show member pathways
 10.64 ACADM HADH
Sources

GO Terms for Hypoglycemia

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Cellular components related to Hypoglycemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 9.55 ACADVL CPT1A CPT2 HADH SLC25A20
2 secretory granule lumen GO:0034774 9.43 AGL GCG INS
3 mitochondrion GO:0005739 9.28 ACADM ACADVL CPT1A CPT2 GCK GLUD1
4 inward rectifying potassium channel GO:0008282 8.96 ABCC8 KCNJ11

Biological processes related to Hypoglycemia according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.99 ACADM ACADVL CPT1A CPT2 HADH SLC16A1
2 metabolic process GO:0008152 9.95 ACADM ACADVL AGL FBP1 GCK GYS2
3 response to drug GO:0042493 9.93 ABCC8 CPT1A CRH HADH KCNJ11
4 carbohydrate metabolic process GO:0005975 9.85 AKT2 FBP1 GCK INS INSR
5 fatty acid metabolic process GO:0006631 9.83 ACADM ACADVL CPT1A CPT2 HADH
6 regulation of lipid metabolic process GO:0019216 9.79 ACADM CPT1A CPT2
7 cellular response to insulin stimulus GO:0032869 9.78 AKT2 GCK INSR
8 insulin receptor signaling pathway GO:0008286 9.77 AKT2 INS INSR
9 glucose homeostasis GO:0042593 9.77 G6PC GCK INS INSR SLC16A1
10 glycogen metabolic process GO:0005977 9.7 AGL AKT2 G6PC
11 positive regulation of glucose import GO:0046326 9.67 AKT2 INS INSR
12 adrenal gland development GO:0030325 9.65 CRH INSR
13 glucose metabolic process GO:0006006 9.65 AKT2 CPT1A GCK INS KCNJ11
14 glycogen catabolic process GO:0005980 9.64 AGL G6PC
15 positive regulation of glycolytic process GO:0045821 9.64 INS INSR
16 positive regulation of glucose import in response to insulin stimulus GO:2001275 9.63 AKT2 INS
17 positive regulation of calcium ion import GO:0090280 9.63 CRH GCG
18 fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 9.62 ACADM ACADVL
19 glycogen biosynthetic process GO:0005978 9.62 ACADM AGL AKT2 GYS2
20 negative regulation of gluconeogenesis GO:0045721 9.61 GCK INS
21 regulation of gluconeogenesis GO:0006111 9.6 ACADM FBP1
22 glucose 6-phosphate metabolic process GO:0051156 9.58 G6PC GCK
23 positive regulation of fatty acid beta-oxidation GO:0032000 9.58 AKT2 CPT1A
24 carnitine shuttle GO:0006853 9.58 CPT1A CPT2 SLC25A20
25 carnitine metabolic process GO:0009437 9.57 ACADM CPT1A
26 positive regulation of respiratory burst GO:0060267 9.56 INS INSR
27 neuron projection maintenance GO:1990535 9.55 INS INSR
28 positive regulation of glycogen biosynthetic process GO:0045725 9.46 AKT2 GCK INS INSR
29 fatty acid beta-oxidation GO:0006635 9.35 ACADM ACADVL CPT1A CPT2 HADH
30 regulation of insulin secretion GO:0050796 9.1 ABCC8 CPT1A GCG GCK KCNJ11 SLC16A1

Molecular functions related to Hypoglycemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.54 CRH GCG INS
2 insulin-like growth factor receptor binding GO:0005159 9.32 INS INSR
3 NAD+ binding GO:0070403 9.26 GLUD1 HADH
4 acyl-CoA dehydrogenase activity GO:0003995 9.16 ACADM ACADVL
5 ATP-activated inward rectifier potassium channel activity GO:0015272 8.96 ABCC8 KCNJ11
6 carnitine O-palmitoyltransferase activity GO:0004095 8.62 CPT1A CPT2
Sources

Sources for Hypoglycemia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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