Hypoglycemia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HYP056 MIFTS: 66	Hypoglycemia Categories: Blood diseases, Endocrine diseases, Metabolic diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Hypoglycemia

MalaCards integrated aliases for Hypoglycemia:

Name: Hypoglycemia ¹² ⁷⁴ ²⁹ ⁵⁴ ⁶ ⁴² ⁴³ ¹⁵ ⁷¹

Hypoglycaemia ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Metabolic diseases
Anatomical: Endocrine diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Endocrine, nutritional and metabolic diseases

Other disorders of glucose regulation and pancreatic internal secretion

Other disorders of pancreatic internal secretion

Hypoglycaemia, unspecified

External Ids:

Disease Ontology ¹² DOID:9993

ICD9CM ³⁴ 251.2

MeSH ⁴³ D007003

NCIt ⁴⁹ C3126

SNOMED-CT ⁶⁷ 302866003

ICD10 ³² E16.2

UMLS ⁷¹ C0020615

Sources

Summaries for Hypoglycemia

MedlinePlus : ⁴² Hypoglycemia means low blood glucose, or blood sugar. Your body needs glucose to have enough energy. After you eat, your blood absorbs glucose. If you eat more sugar than your body needs, your muscles, and liver store the extra. When your blood sugar begins to fall, a hormone tells your liver to release glucose. In most people, this raises blood sugar. If it doesn't, you have hypoglycemia, and your blood sugar can be dangerously low. Signs include Hunger Shakiness Dizziness Confusion Difficulty speaking Feeling anxious or weak In people with diabetes, hypoglycemia is often a side effect of diabetes medicines. Eating or drinking something with carbohydrates can help. If it happens often, your health care provider may need to change your treatment plan. You can also have low blood sugar without having diabetes. Causes include certain medicines or diseases, hormone or enzyme deficiencies, and tumors. Laboratory tests can help find the cause. The kind of treatment depends on why you have low blood sugar. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Hypoglycemia, also known as hypoglycaemia, is related to hyperinsulinemic hypoglycemia, familial, 2 and hyperinsulinemic hypoglycemia, familial, 6, and has symptoms including sugar craving An important gene associated with Hypoglycemia is G6PC (Glucose-6-Phosphatase Catalytic Subunit), and among its related pathways/superpathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs lanreotide and Gliclazide have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and liver, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : ¹² A glucose metabolism disease that is characterized by abnormally low levels of blood glucose.

Wikipedia : ⁷⁴ Hypoglycemia, also known as low blood sugar, is a fall in blood sugar to levels below normal. This may... more...

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Related Diseases for Hypoglycemia

Diseases related to Hypoglycemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1111)

#	Related Disease	Score	Top Affiliating Genes
1	hyperinsulinemic hypoglycemia, familial, 2	35.2	KCNJ11 INS ABCC8
2	hyperinsulinemic hypoglycemia, familial, 6	34.9	SLC16A1 HADH GLUD1 GCK ABCC8
3	hyperinsulinemic hypoglycemia, familial, 7	34.9	SLC16A1 KCNJ11 HADH GLUD1 GCK ABCC8
4	hyperinsulinemic hypoglycemia	34.5	SLC16A1 KCNJ11 INSR INS HADH GLUD1
5	fasting hypoglycemia	34.3	INSR GYS2 GLUD1 CRH ACADM
6	glycogen storage disease type 0	33.7	GYS2 AGL
7	carnitine palmitoyltransferase ii deficiency, infantile	33.7	SLC25A20 HADH CPT2 CPT1A ACADVL ACADM
8	fructose-1,6-bisphosphatase deficiency	33.3	GCK GCG G6PC FBP1 ABCC8
9	carnitine palmitoyltransferase i deficiency	33.2	CPT2 CPT1A ACADVL ACADM
10	glycogen storage disease ia	33.2	INS GCG G6PC FBP1 AGL
11	carnitine-acylcarnitine translocase deficiency	33.2	SLC25A20 CPT2 CPT1A ACADVL
12	3-hydroxyacyl-coa dehydrogenase deficiency	33.0	HADH GLUD1 GCK ACADVL ACADM
13	acyl-coa dehydrogenase, very long-chain, deficiency of	33.0	SLC25A20 HADH CPT2 ACADVL ACADM
14	acyl-coa dehydrogenase, medium-chain, deficiency of	33.0	SLC25A20 HADH CPT2 ACADVL ACADM
15	multiple acyl-coa dehydrogenase deficiency	32.9	SLC25A20 HADH CPT2 ACADVL ACADM
16	hyperinsulinism	32.8	SLC16A1 KCNJ11 INSR INS HADH GLUD1
17	long-chain 3-hydroxyacyl-coa dehydrogenase deficiency	32.7	HADH ACADVL ACADM
18	carbonic anhydrase va deficiency, hyperammonemia due to	32.7	SLC25A20 GLUD1
19	mitochondrial trifunctional protein deficiency	32.7	SLC25A20 HADH CPT2 ACADVL ACADM
20	glycogen storage disease vi	32.6	GYS2 G6PC AGL
21	epiphyseal dysplasia, multiple, with early-onset diabetes mellitus	32.6	KCNJ11 INS ABCC8
22	carnitine deficiency, systemic primary	32.5	SLC25A20 HADH CPT2 ACADVL ACADM
23	acyl-coa dehydrogenase, short-chain, deficiency of	32.4	HADH CPT2 ACADVL ACADM
24	donohue syndrome	32.3	INSR INS GCK
25	insulinoma	32.1	INS GCK GCG ABCC8
26	hyperglycemia	32.0	KCNJ11 INSR INS GCK GCG G6PC
27	diabetes mellitus	31.6	KCNJ11 INSR INS GCK GCG G6PC
28	hypoglycemic coma	31.5	INS GCG
29	diabetes mellitus, ketosis-prone	31.5	KCNJ11 INS GCG ABCC8
30	gestational diabetes	31.3	KCNJ11 INSR INS GCK GCG ABCC8
31	insulin-like growth factor i	31.3	INSR INS AKT2
32	glycogen storage disease	31.2	INS GYS2 G6PC CPT2 AGL
33	maturity-onset diabetes of the young	31.1	KCNJ11 INS GCK GCG G6PC ABCC8
34	glucose intolerance	31.0	KCNJ11 INSR INS GCK GCG ABCC8
35	munchausen by proxy	30.8	KCNJ11 GCK ABCC8
36	maturity-onset diabetes of the young, type 3	30.8	KCNJ11 INS GCK ABCC8
37	diabetes mellitus, noninsulin-dependent	30.8	KCNJ11 INSR INS GCK GCG G6PC
38	asphyxia neonatorum	30.8	SLC16A1 KCNJ11 INS HADH ABCC8
39	monocarboxylate transporter 1 deficiency	30.7	SLC16A1 INS GLUD1
40	neonatal diabetes mellitus	30.7	KCNJ11 INS GCK GCG ABCC8
41	pituitary gland disease	30.7	INS GCG CRH
42	lipoid congenital adrenal hyperplasia	30.7	INS CRH ACADM
43	diabetes mellitus, permanent neonatal 4	30.7	KCNJ11 INS GCK ABCC8
44	monogenic diabetes	30.7	KCNJ11 INS GCK ABCC8
45	diabetes mellitus, permanent neonatal 1	30.6	KCNJ11 INS GCK ABCC8
46	transient neonatal diabetes mellitus	30.6	KCNJ11 INS GCK ABCC8
47	maple syrup urine disease	30.6	HADH GLUD1 ACADM
48	atrial standstill 1	30.6	SLC25A20 CPT2 AGL ACADVL
49	acute insulin response	30.5	KCNJ11 INS GCG ABCC8
50	3-methylcrotonyl-coa carboxylase deficiency	30.5	HADH ACADVL ACADM

Comorbidity relations with Hypoglycemia via Phenotypic Disease Network (PDN): (show all 30)

Active Peptic Ulcer Disease	Acute Cystitis
Acute Kidney Failure	Alzheimer Disease
Benign Essential Hypertension	Bronchitis
Cerebral Atherosclerosis	Decubitus Ulcer
Deficiency Anemia	Diabetic Polyneuropathy
Encephalopathy	Familial Atrial Fibrillation
First-Degree Atrioventricular Block	Generalized Atherosclerosis
Heart Disease	Hypertension, Essential
Hypoglycemic Coma	Hypothyroidism
Intermediate Coronary Syndrome	Iron Deficiency Anemia
Kidney Disease	Microvascular Complications of Diabetes 1
Microvascular Complications of Diabetes 7	Mitral Valve Disease
Peripheral Vascular Disease	Protein-Energy Malnutrition
Respiratory Failure	Schizophreniform Disorder
Sinoatrial Node Disease	Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Hypoglycemia:

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Symptoms & Phenotypes for Hypoglycemia

UMLS symptoms related to Hypoglycemia:

sugar craving

GenomeRNAi Phenotypes related to Hypoglycemia according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00221-A-1	9.77	AKT2 GCK INSR
2	Decreased viability	GR00221-A-2	9.77	CPT2 GCK INSR
3	Decreased viability	GR00221-A-3	9.77	AKT2 GCK INSR
4	Decreased viability	GR00221-A-4	9.77	AKT2 CPT2 GCK INSR
5	Decreased viability	GR00249-S	9.77	ACADM AGL G6PC GCG HADH
6	Decreased viability	GR00301-A	9.77	AKT2
7	Decreased viability	GR00342-S-3	9.77	AKT2
8	Decreased viability	GR00386-A-1	9.77	ACADM AGL GCG SLC16A1
9	Decreased viability	GR00402-S-2	9.77	ACADM ACADVL CPT2 GLUD1

MGI Mouse Phenotypes related to Hypoglycemia:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.3	ABCC8 ACADM ACADVL AGL AKT2 CPT1A
2	cardiovascular system	MP:0005385	10.1	ACADM ACADVL CPT1A CPT2 GCK GYS2
3	endocrine/exocrine gland	MP:0005379	10.07	ABCC8 AKT2 CRH GCK GLUD1 HADH
4	adipose tissue	MP:0005375	10.03	ACADVL AKT2 CRH HADH INS INSR
5	liver/biliary system	MP:0005370	10.03	ACADM ACADVL AGL AKT2 CRH G6PC
6	mortality/aging	MP:0010768	9.97	ACADM ACADVL AGL AKT2 CPT1A CPT2
7	muscle	MP:0005369	9.56	ACADM ACADVL AGL AKT2 GYS2 INS
8	renal/urinary system	MP:0005367	9.17	CRH G6PC GCK HADH INS INSR

Sources

Drugs & Therapeutics for Hypoglycemia

Drugs for Hypoglycemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 509)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

lanreotide

Approved

Phase 4

108736-35-2

Gliclazide

Approved

Phase 4

21187-98-4

3475

Linagliptin

Approved

Phase 4

668270-12-0

10096344

Epinephrine

Approved, Vet_approved

Phase 4

51-43-4

5816

Racepinephrine

Approved

Phase 4

329-65-7

838

Ethanol

Approved

Phase 4

64-17-5

702

Hydrocortisone

Approved, Vet_approved

Phase 4

50-23-7

5754

Hydrocortisone acetate

Approved, Vet_approved

Phase 4

50-03-3

Glipizide

Approved, Investigational

Phase 4

29094-61-9

3478

Fosaprepitant

Approved

Phase 4

172673-20-0

219090

Aprepitant

Approved, Investigational

Phase 4

170729-80-3

6918365 151165

Caffeine

Approved

Phase 4

58-08-2

2519

Simvastatin

Approved

Phase 4

79902-63-9

54454

Midazolam

Approved, Illicit

Phase 4

59467-70-8

4192

Omeprazole

Approved, Investigational, Vet_approved

Phase 4

73590-58-6

4594

Chlorzoxazone

Approved

Phase 4

95-25-0

2733

Dextromethorphan

Approved

Phase 4

125-71-3

5360696 5362449

Tolbutamide

Approved, Investigational

Phase 4

64-77-7

5505

Guaifenesin

Approved, Investigational, Vet_approved

Phase 4

93-14-1

3516

Bupropion

Approved

Phase 4

34911-55-2, 34841-39-9

444

Dexmedetomidine

Approved, Vet_approved

Phase 4

113775-47-6

5311068 68602

Haloperidol

Approved

Phase 4

52-86-8

3559

Diazepam

Approved, Illicit, Investigational, Vet_approved

Phase 4

439-14-5

3016

Esmolol

Approved

Phase 4

103598-03-4, 81147-92-4

59768

Acarbose

Approved, Investigational

Phase 4

56180-94-0

441184

Aspirin

Approved, Vet_approved

Phase 4

50-78-2

2244

Alogliptin

Approved

Phase 4

850649-61-5

11450633

Repaglinide

Approved, Investigational

Phase 4

135062-02-1

65981

Spironolactone

Approved

Phase 4

52-01-7, 1952-01-7

5833

Glucagon

Approved

Phase 4

16941-32-5

Exenatide

Approved, Investigational

Phase 4

141758-74-9

15991534

Empagliflozin

Approved

Phase 4

864070-44-0

Ursodeoxycholic acid

Approved, Investigational

Phase 4

128-13-2

31401

Lidocaine

Approved, Vet_approved

Phase 4

137-58-6

3676

Naloxone

Approved, Vet_approved

Phase 4

465-65-6

5284596

Pioglitazone

Approved, Investigational

Phase 4

111025-46-8

4829

Zinc

Approved, Investigational

Phase 4

7440-66-6

32051

Insulin detemir

Approved

Phase 4

169148-63-4

5311023

Glimepiride

Approved

Phase 4

93479-97-1

3476

tannic acid

Approved

Phase 4

1401-55-4

Benzocaine

Approved, Investigational

Phase 4

94-09-7, 1994-09-7

2337

Saxagliptin

Approved

Phase 4

361442-04-8

11243969

Dopamine

Approved

Phase 4

51-61-6, 62-31-7

681

Prednisone

Approved, Vet_approved

Phase 4

53-03-2

5865

Canagliflozin

Approved

Phase 4

842133-18-0

Methylprednisolone

Approved, Vet_approved

Phase 4

83-43-2

6741

Prednisolone phosphate

Approved, Vet_approved

Phase 4

302-25-0

Methylprednisolone hemisuccinate

Approved

Phase 4

2921-57-5

Prednisolone

Approved, Vet_approved

Phase 4

50-24-8

5755

Prednisolone acetate

Approved, Vet_approved

Phase 4

52-21-1

Interventional clinical trials:

(show top 50) (show all 1775)

#	Name	Status	NCT ID	Phase	Drugs
1	Comparison of Two Strategies of Hypoglycemia Correction in ICU	Unknown status	NCT01387477	Phase 4	Lactate;Glucose
2	Randomized, Open Prospective Study of the Effect of SGLT-2 Inhibitor Dapagliflozin on Glycemic Variability in Patients With Diabetes Mellitus Type 2	Unknown status	NCT02719756	Phase 4	Metformin;Dapagliflozin;Metformin up-titration
3	The Effect of Saxagliptin on Glucose Fluctuation and Immune Regulation in Patients With Type 1 Diabetes	Unknown status	NCT02307695	Phase 4	Saxagliptin;Insulin
4	Do Sulphonylureas Preserve Cortical Function During Hypoglycaemia?	Unknown status	NCT00472875	Phase 4	Glibenclamide
5	Impact of Insulin Detemir Versus Insulin Glargine on Glycaemic Control and Metabolism During Exercise in Type 1 Diabetes	Unknown status	NCT01440439	Phase 4	Insulin glargine;Insulin detemir
6	Pramlintide (Symlin) for the Treatment of Hypoglycemia Following Gastric Bypass Surgery	Unknown status	NCT01841359	Phase 4	Pramlintide
7	Is Insulin NovoRapid Better Than Actrapid for Treating Type 1 Diabetic Patients When Simultaneously, Daily Adjusting the Insulin Dose?	Unknown status	NCT00145353	Phase 4	Insulin NovoRapid versus Actrapid
8	Real-Time Continuous Glucose Monitoring in Pre-School Children With Type-1 Diabetes Mellitus	Unknown status	NCT01016457	Phase 4
9	Treatment of Hypoglycemia With Glucagon Among Patients With Type 1 Diabetes Mellitus	Unknown status	NCT02232971	Phase 4	Glucagon
10	Basal-bolus Insulin Therapy With Insulin Degludec and Insulin Aspart Versus Standard Therapy for the Inpatient Management of Type 2 Diabetes: the IDA2 Study	Unknown status	NCT03244241	Phase 4	Insulin Degludec 100 UNT/ML [Tresiba]
11	Effects of Intensive Insulin Therapy on Mortality, Morbidity and Long Term Neurologic Outcome in Neurosurgical Intensive Care Patients	Unknown status	NCT00505505	Phase 4	Insulin (Actrapid)
12	The Efficacy and Safety of Sodium-glucose Co-transporter 2 Inhibitor or Dipeptidyl Peptidase 4 Inhibitor Added to Premix Insulin Injection Twice Daily in Uncontrolled Type 2 Diabetes Patients	Unknown status	NCT03458715	Phase 4	SGLT2 inhibitor (Empagliflozin 25 MG);DPP4 inhibitor (Linagliptin 5 MG)
13	Investigation of a Switch From Insulin Therapy to a Metformin & Saxagliptin Combination in Patients With Type 2 Diabetes Mellitus	Unknown status	NCT01206647	Phase 4	Metformin and Saxagliptin
14	A Randomized, Open, Controlled, Parallel Group Study of Adding Linagliptin to Control Glycemic Variability and HbA1c in Peritoneal Dialysis Patients With Type 2 Diabetes(PDPD) With Premixed Insulin Therapy	Unknown status	NCT03320031	Phase 4	Linagliptin;Humalog Mix 75/25
15	Optimal Insulin Correction Factor in Post- High Intensity Exercise Hyperglycemia in Adults With Type 1 Diabetes: The FIT Study	Unknown status	NCT03057470	Phase 4	50% bolus insulin correction;100% bolus insulin correction;150% bolus insulin correction
16	Metformin and Sitagliptin Therapy for Adult Patients With Type 2 Diabetes Admitted to the General Medical Unit	Unknown status	NCT02250794	Phase 4	metformin and sitagliptin;insulin glargine and insulin lispro;metformin and sitagliptin;insulin glargine and insulin lispro
17	Organization Program of DiabEtes INsulIN ManaGement: An Open, Multi-center, Prospective, Randomized, 16-week, Controlled Clinical Study	Unknown status	NCT01338376	Phase 4	Scilin®M30
18	A Pilot Study of Outpatient Discharge Therapy With Saxagliptin + Metformin XR or Sulphonylurea for Recently Diagnosed Type 2 Diabetes Presenting With Severe Hyperglycemia	Unknown status	NCT01267448	Phase 4	Glipizide XL;Saxagliptin + Metformin XR;Metformin XR
19	Explore the Efficacy of Acarbose and Metformin on Blood Glucose Fluctuation When Combined With Premix Insulin in Chinese Type 2 Diabetes by CGMS	Unknown status	NCT02438397	Phase 4	premix insulin;metformin;Acarbose
20	A Double-Blind, Randomized, Parallel, Comparative Study to Evaluate the Efficacy and Safety of an Antidiabetic Agent Repaglinide for the Treatment of Type 2 Diabetes Mellitus Patients	Unknown status	NCT00336310	Phase 4	Repaglinide
21	Treatment With Lanreotide Autogel (Somatostatin Analogue) in Patients With Congenital Hyperinsulinism of Infancy Already Treated With Somatostatin Analog by Pump	Unknown status	NCT01070758	Phase 4	Lanreotide autogel
22	GLP-1 Analogue Treatment in Uncontrolled Type 1 Diabetic Patients	Unknown status	NCT01592279	Phase 4	liraglutide;Insulin injections
23	The Effect of the GLP-1 Receptor Agonists on Blood Levels of Lipoprotein (a)	Unknown status	NCT02501850	Phase 4	Liraglutide;metformin
24	Effects of SGLT2 Inhibitor on Markers of Inflammation, Atherosclerosis and Left Ventricular Strain in Diabetic Patients With Coronary Artery Disease	Unknown status	NCT03398577	Phase 4	Dapagliflozin 10 MG [Farxiga];Placebo Oral Tablet
25	The Therapeutic Effects of Combination of Insulin With Berberine on the Patients With Stess Hyperlipemia:a Prospective, Double Blind, Randomized, Placebo-controlled, Single-center Clinical Trial	Unknown status	NCT02806999	Phase 4	Berberine; Insulin;Insulin
26	Randomized, Long-Term Study About the Effects of Analogue Versus Human Insulin Based Regimens (Insulin Detemir and Aspart Versus NPH- and Regular Human Insulin) on Metabolic Control and Myocardial Function in People With Type 2 Diabetes.	Unknown status	NCT00747409	Phase 4	insulin aspart and detemir (NovoRapid, Levemir);human regular insulin and NPH insulin (Actrapid, Protaphne)
27	A Phase IV, Multicenter, Randomized, Active Comparator Controlled Study of the Addition of Pioglitazone Compared With Glimepiride in Subjects With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Metformin and Alogliptin	Unknown status	NCT02426294	Phase 4	Pioglitazone;Glimepiride
28	An Open-label, Randomized , Phase 4 Study to Compare the Different Efficacies of α-glucosidase Inhibitor and Sulfonylurea on Improvement of Intestinal Microbiome and Serum Incretins in Patients With Type 2 Diabetes	Unknown status	NCT01758471	Phase 4	Glipizide;Acarbose
29	Improving Glycaemic Control in Malaysian Patients With Type 2 Diabetes Mellitus With Insulin Pump Therapy	Unknown status	NCT03112538	Phase 4	Multiple daily injections of insulin
30	Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics- Double Blind Placebo Controlled Study	Unknown status	NCT00845936	Phase 4	Metformin
31	Study Comparing Prandial Insulin Aspart vs. Technosphere Insulin in Patients With Type 1 Diabetes on Multiple Daily Injections: Investigator-Initiated A Real-life Pilot Study—STAT Study	Unknown status	NCT03143816	Phase 4	Technosphere insulin
32	Healthy Heart Study: Can Insulin Glargine Improve Myocardial Function in Patients With Type 2 Diabetes and Coronary Artery Disease? A Prospective, Randomized, Controlled Clinical Study With Blinded Analysis of Ultrasound Data	Unknown status	NCT01035528	Phase 4	insulin glargine;metformin
33	Effect of Dapagliflozin on Cardio-Metabolic Risk Factors in Patients With Type-2 Diabetes	Unknown status	NCT03377335	Phase 4	Dapagliflozin 10mg;Metformin
34	Endobarrier Treatment in Obese Subjects With T2DM	Unknown status	NCT01718457	Phase 4
35	Absorption and Utilization of a Mixed Meal in Type 1 Diabetes: Creation of a Biological and In Silico Biobank for the Optimization of Artificial Pancreas Systems. A Pilot Study.	Unknown status	NCT01800734	Phase 4
36	Mechanistic Study of the Systolic Blood Pressure Lowering Effect of Dapagliflozin in Type 2 Diabetes	Unknown status	NCT02372955	Phase 4	dapagliflozin;glimpiride
37	Effect of Linagliptin on Intestinal Triglyceride-rich-lipoprotein Metabolism in Type 2 Diabetic Patients	Unknown status	NCT02280174	Phase 4	linagliptin
38	Effects on Incidence of Cardiovascular Events of the Addition of Pioglitazone as Compared With a Sulphonylurea in Type 2 Diabetic Patients Inadequately Controlled With Metformin.	Unknown status	NCT00700856	Phase 4	add-on pioglitazone;add-on sulphonylurea
39	Can Hypoglycaemia Awareness Be Restored in Individuals With Type 1 Diabetes and Severe Hypoglycaemia Employing Optimised Subcutaneous Insulin Regime or Continuous Subcutaneous Insulin Infusion Pump	Completed	NCT00360984	Phase 4	insulin glargine
40	The Effect of Insulin Analogues and Human Insulin on the Incidence of Severe Hypoglycaemia in Hypoglycaemia Prone Type 1 Diabetic Patients	Completed	NCT00346996	Phase 4	insulin levemir / aspart;human insulin /insulin isophane
41	The Effect of Insulin Degludec on Risk of Symptomatic Nocturnal Hypoglycaemia in Subjects With Type 1 Diabetes and High Risk of Nocturnal Severe Hypoglycaemia	Completed	NCT02192450	Phase 4	Insulin aspart/glargine;Insulin aspart/degludec
42	The Late Effects of Ethanol Intake on the Glucose Response to Subcutaneous Glucagon in Type 1 Diabetes	Completed	NCT02881060	Phase 4
43	A Phase IIIb/IV, Multinational, Multicentre, Randomised, Open Study to Establish the Optimal Method for Initiating and Maintaining Lantus® (Insulin Glargine) Therapy Based on a Comparison of Two Treatment Algorithms to Determine Optimal Metabolic Outcomes, Safety, and Satisfaction in Subjects With Type 1 Diabetes Mellitus/ "HALT" Sub-study: Multicentre, Open Clinical Trial to Assess the Effect of Insulin Glargine on Symptomatic Hypoglycaemia, Fear of Hypoglycaemia and Quality of Life in Patients With Type 1 Diabetes	Completed	NCT00390728	Phase 4	Insulin Glargine
44	A Double-blind, Randomised, Crossover Study to Investigate the Difference in Frequency of Episodes of Hypoglycaemia During Treatment With Biphasic Insulin Aspart 30 Compared to Biphasic Human Insulin 30 in Patients With Well-controlled Type 2 Diabetes	Completed	NCT01487798	Phase 4	biphasic human insulin 30;biphasic insulin aspart 30
45	National (Brazil), Phase IV, Multicentric, Open Label, Parallel, Comparative Study of the Use of Insulin Glargine + Glulisine or Insulin Regular + NPH Insulin (Isophane Insulin) in Type 2 Diabetes Mellitus Patients With Moderate Renal Failure.	Completed	NCT01122979	Phase 4	INSULIN GLARGINE;NPH insulin (insulin isophane);INSULIN GLULISINE;Regular insulin
46	Glucagon Efficiency After High and Low Carbohydrate Diet	Completed	NCT02578498	Phase 4
47	Efficacy of a Continuous GLP-1 Infusion in Comparison to a Structured Insulin Infusion Protocol to Reach Normoglycemia in Non-Fasted Type 2 Diabetic Patients	Completed	NCT00859079	Phase 4	GLP-1;Human regular insulin intravenously
48	Randomized, Double-blind, Placebo-controlled Trial on the Effectiveness and Safety of Dapagliflozin for Blood Glucose Control During Glucocorticoid Treatment for Acute Exacerbation COPD	Completed	NCT02253121	Phase 4	Dapagliflozin;Sliding scale insulin
49	Use of Diazoxide in Acute Hypoglycaemia	Completed	NCT01488136	Phase 4	Diazoxide;Placebo
50	Bedtime Insulin Glargine or Bedtime Neutral Protamine Lispro Combined With Sulfonylurea and Metformin in Type 2 Diabetes. A Randomized, Controlled Trial	Completed	NCT00641407	Phase 4	NPL insulin;Insulin glargine

Search NIH Clinical Center for Hypoglycemia

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

DEXTROSE 100% PWDR

Diazoxide

Glucagon

Glucose

GLUCOSE LIQUID

Cochrane evidence based reviews: hypoglycemia

Sources

Genetic Tests for Hypoglycemia

Genetic tests related to Hypoglycemia:

#	Genetic test	Affiliating Genes
1	Hypoglycemia ²⁹

Sources

Anatomical Context for Hypoglycemia

MalaCards organs/tissues related to Hypoglycemia:

⁴⁰

Brain, Testes, Liver, Pancreas, Pituitary, Kidney, Heart

Sources

Publications for Hypoglycemia

Articles related to Hypoglycemia:

(show top 50) (show all 39049)

#	Title	Authors	PMID	Year
1	Effects of Germline VHL Deficiency on Growth, Metabolism, and Mitochondria. ⁶¹ ⁴²	Perrotta S...Della Ragione F	32101665	2020
2	Low ambient temperatures correlate with increased risk of hypoglycemia in patients with type 2 diabetes: An ecological study in Taiwan. ⁶¹ ⁴²	Lai SW...Lai YJ	32080143	2020
3	Continuous Glucose Monitoring Systems: Are They Useful for Evaluating Glycemic Control in Children with Hyperinsulinism? ⁶¹ ⁴²	Rayannavar A...De Leon DD	32208390	2019
4	IGF2 over-expression in solitary fibrous tumours is independent of anatomical location and is related to loss of imprinting. ⁶¹ ⁵⁴	Hajdu M...Antonescu CR	20527023	2010
5	Prolonged survival and improved glycemia in BioBreeding diabetic rats after early sustained exposure to glucagon-like peptide 1. ⁶¹ ⁵⁴	Yanay O...Osborne WR	20527046	2010
6	[A new therapeutic possibility for type 2 diabetes: DPP-4 inhibitors (sitagliptin)]. ⁶¹ ⁵⁴	Abel T...Feher J	20519186	2010
7	Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations. ⁶¹ ⁵⁴	Flanagan SE...Ellard S	20164212	2010
8	Prevention of nocturnal hypoglycemia using predictive alarm algorithms and insulin pump suspension. ⁵⁴ ⁶¹	Buckingham B...Doyle FJ	20200307	2010
9	Type 2 diabetes comorbidities and treatment challenges: rationale for DPP-4 inhibitors. ⁶¹ ⁵⁴	Hollander PA...Kushner P	20463416	2010
10	Glucose transporter type 1 deficiency: ketogenic diet in three patients with atypical phenotype. ⁵⁴ ⁶¹	Veggiotti P...Balottin U	19515520	2010
11	Improved glycaemic control with minimal hypoglycaemia and no weight change with the once-daily human glucagon-like peptide-1 analogue liraglutide as add-on to sulphonylurea in Japanese patients with type 2 diabetes. ⁶¹ ⁵⁴	Kaku K...Seino Y	20380655	2010
12	A case of a giant phyllodes tumor of the breast with hypoglycemia caused by high-molecular-weight insulin-like growth factor II. ⁶¹ ⁵⁴	Hino N...Tsuyuguchi M	19259766	2010
13	Transient salt wasting in POMC-deficiency due to infection induced stress. ⁶¹ ⁵⁴	Darcan S...Asar G	19998238	2010
14	Brain glucosamine boosts protective glucoprivic feeding. ⁶¹ ⁵⁴	Osundiji MA...Evans ML	20179264	2010
15	Solitary fibrous tumor of soft tissue: a case report and immunohistochemical study. ⁶¹ ⁵⁴	Yuri T...Tsubura A	20340008	2010
16	Effects of incretin hormones on beta-cell mass and function, body weight, and hepatic and myocardial function. ⁶¹ ⁵⁴	Mudaliar S...Henry RR	20206728	2010
17	Type B insulin resistance syndrome with systemic lupus erythematosus. ⁶¹ ⁵⁴	Sato N...Tomino Y	20129024	2010
18	Reaching HbA1c goals with saxagliptin in combination with other oral antidiabetic drugs. ⁵⁴ ⁶¹	LaSalle JR	20107298	2010
19	A novel mutation in the glycogen synthase 2 gene in a child with glycogen storage disease type 0. ⁵⁴ ⁶¹	Soggia AP...Pereira MA	20051115	2010
20	Hypoglycemia due to ectopic secretion of insulin-like growth factor-I in a patient with an isolated sarcoidosis of the spleen. ⁶¹ ⁵⁴	Ogiwara Y...Ito H	20081321	2010
21	[Late onset 3-HMG-CoA lyase deficiency: a rare but treatable disorder]. ⁵⁴ ⁶¹	Pierron S...Acquaviva C	19932602	2010
22	Therapeutic options that provide glycemic control and weight loss for patients with type 2 diabetes. ⁶¹ ⁵⁴	Blevins T	20107301	2010
23	Novel FBP1 gene mutations in Arab patients with fructose-1,6-bisphosphatase deficiency. ⁶¹ ⁵⁴	Faiyaz-Ul-Haque M...Zaidi SH	19259699	2009
24	In vivo phosphoenolpyruvate carboxykinase promoter mapping identifies disrupted hormonal synergism as a target of inflammation during sepsis in mice. ⁵⁴ ⁶¹	Chichelnitskiy E...Herzig S	19821526	2009
25	Hyperinsulinaemic hypoglycaemia associated with a heterozygous missense mutation of R1174W in the insulin receptor (IR) gene. ⁶¹ ⁵⁴	Huang Z...Weng J	19170714	2009
26	Treatment of type 1 diabetic patients with glucagon-like peptide-1 (GLP-1) and GLP-1R agonists. ⁶¹ ⁵⁴	Kielgast U...Madsbad S	19925391	2009
27	Differential effects of insulin detemir and neutral protamine Hagedorn (NPH) insulin on hepatic glucose production and peripheral glucose uptake during hypoglycaemia in type 1 diabetes. ⁶¹ ⁵⁴	Smeeton F...Russell-Jones DL	19707744	2009
28	Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia. ⁶¹ ⁵⁴	Osbak KK...Gloyn AL	19790256	2009
29	DPP-4 inhibitors in clinical practice. ⁶¹ ⁵⁴	Palalau AI...Barnett AH	19940419	2009
30	New therapies for diabesity. ⁶¹ ⁵⁴	Bailey CJ	19793506	2009
31	Treatment of dwarfism with recombinant human insulin-like growth factor-1. ⁵⁴ ⁶¹	Ranke MB...Bettendorf M	19946434	2009
32	No increased risk of hypoglycaemic episodes during 48 h of subcutaneous glucagon-like-peptide-1 administration in fasting healthy subjects. ⁵⁴ ⁶¹	Lerche S...Brock B	19094067	2009
33	Malignant solitary fibrous tumor: report of 3 cases with unusual features. ⁵⁴ ⁶¹	Hu Y...Xu H	19349855	2009
34	Liraglutide: a once-daily incretin mimetic for the treatment of type 2 diabetes mellitus. ⁵⁴ ⁶¹	Neumiller JJ...Campbell RK	19638470	2009
35	Defining the importance of daily glycemic control and implications for type 2 diabetes management. ⁶¹ ⁵⁴	Bode BW	19820277	2009
36	Hypoglycemia with intensive insulin therapy in critically ill patients: predisposing factors and association with mortality. ⁶¹ ⁵⁴	Arabi YM...Rishu AH	19623047	2009
37	Differential chemistry (structure), mechanism of action, and pharmacology of GLP-1 receptor agonists and DPP-4 inhibitors. ⁶¹ ⁵⁴	Neumiller JJ	19801361	2009
38	Beta-human chorionic gonadotropin production associated with phyllodes tumor of the breast: an unusual paraneoplastic phenomenon. ⁵⁴ ⁶¹	Reisenbichler ES...Hameed O	19624411	2009
39	Selecting among ADA/EASD tier 1 and tier 2 treatment options. ⁵⁴ ⁶¹	McGill JB	19744422	2009
40	Short-term effects of the long-acting insulin analog detemir and human insulin on plasma levels of insulin-like growth factor-I and its binding proteins in humans. ⁵⁴ ⁶¹	Porcellati F...Fanelli CG	19470629	2009
41	Treatment of type 2 diabetes with glucagon-like peptide-1 receptor agonists. ⁶¹ ⁵⁴	Hansen KB...Vilsboll T	19624785	2009
42	Hemangiopericytoma-associated hypoglycemia improved by glucocorticoid therapy: a case report. ⁵⁴ ⁶¹	Anaforoglu I...Algun E	19387873	2009
43	[Diagnosis of glycogen storage disease type IIIA by detecting glycogen debranching enzyme activity, glycogen content and structure in muscle]. ⁵⁴ ⁶¹	Wang W...Li F	19951495	2009
44	Delay in blood glucose monitoring during an insulin infusion protocol is associated with increased risk of hypoglycemia in intensive care units. ⁵⁴ ⁶¹	Garg R...Pendergrass M	19670374	2009
45	3-Hydroxyacyl-coenzyme A dehydrogenase deficiency and hyperinsulinemic hypoglycemia: characterization of a novel mutation and severe dietary protein sensitivity. ⁶¹ ⁵⁴	Kapoor RR...Hussain K	19417036	2009
46	Lys169 of human glucokinase is a determinant for glucose phosphorylation: implication for the atomic mechanism of glucokinase catalysis. ⁵⁴ ⁶¹	Zhang J...Jiang H	19617908	2009
47	Expression of insulin-like growth factor 2 in mesenchymal neoplasms. ⁶¹ ⁵⁴	Steigen SE...Nielsen TO	19407853	2009
48	[A case of retroperitoneal solitary fibrous tumor associated with hypoglycemia]. ⁶¹ ⁵⁴	Kawashima A...Kitaoka H	19673425	2009
49	Hypoglycemia from IGF2 overexpression associated with activation of fetal promoters and loss of imprinting in a metastatic hemangiopericytoma. ⁵⁴ ⁶¹	Lawson EA...Klibanski A	19383775	2009
50	Factors determining inadequate hypoglycaemia during insulin tolerance testing (ITT) after pituitary surgery. ⁶¹ ⁵⁴	Lee P...Ho KK	19178524	2009

Sources

Genes for Hypoglycemia

Genes related to Hypoglycemia (1 elite genes):

(show top 50) (show all 54)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	G6PC	Glucose-6-Phosphatase Catalytic Subunit	Protein Coding	448.98	Pathogenic ⁶ DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)	8949949 10625614 11899241 (more) 17023421 12189168 12373573 18996862
2	ABCC8	ATP Binding Cassette Subfamily C Member 8	Protein Coding	58.09	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)	2166699 8314007 10615958 (more) 10334322 8751851 11226335 9648840 18339976 18250167 11938023 12199344 16023110 12453898 10323384 8923010 11772909 15356046 11867634 9041101 12606521 7633448 8650576 9100595
3	KCNJ11	Potassium Inwardly Rectifying Channel Subfamily J Member 11	Protein Coding	54.17	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)	16142506 10615958 19214942 (more) 10334322 11938023 11867634 12199344 8923010 9648840 10323384 12453898
4	HADH	Hydroxyacyl-CoA Dehydrogenase	Protein Coding	51.23	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)	17491019 14693719
5	GCK	Glucokinase	Protein Coding	51.2	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)	14517946 15277402 19790256 (more) 19336674 20179264 10480597 10525657 12941786 11916904 11119017 12475782 16938872 18489404 17082186 10805170 19617908 18325809 18370929 18208578 17976205 11916951 12228011 15677479 16159025
6	GCG	Glucagon	Protein Coding	44.14	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Proteins Functions (show sections)	9794105 12941722 12547550 (more) 11889194 18957502 17698900 19094067 7627258 7672496 11383230 19170358 20380655 19638470 19439067 16338283 9831697 20527046 16629719 16490580 16682937 15585995 19925391 19591659 19555131 18769687 11575444 9802745 9200302 17719327 16132964 16120042 10630380 12973381 19793506 17174230 16855072 7612912 16179267 8894501 19707284 18600596
7	GLUD1	Glutamate Dehydrogenase 1	Protein Coding	40.52	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Variants (show sections)	11872671 12444083 15530324 (more) 15756227 18321734 14532172
8	SLC25A20	Solute Carrier Family 25 Member 20	Protein Coding	38.55	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)	15363639 8450053 11350184 (more) 15365988 16602102 10655160 15159657 12507404
9	ACADM	Acyl-CoA Dehydrogenase Medium Chain	Protein Coding	38.46	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)	2387217 7929823 9498103 (more) 1594327 1539377 11229423 10529389 18753599 8017963 15053333 15858970
10	GYS2	Glycogen Synthase 2	Protein Coding	38.21	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)	20051115 11483824
11	INSR	Insulin Receptor	Protein Coding	38.14	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Variants (show sections)	11217151 17956452 17296513 (more) 19170714 19318401 1874939 14722613 17299733 16761106 7821734 11443207 10443650 17445543 8348701 1727740 19411227 15992683 14764948 12794609 10500933 16227169 10633872 20129024 18691043 15111569 14694017 18156285
12	FBP1	Fructose-Bisphosphatase 1	Protein Coding	34.8	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)	19259699
13	SLC16A1	Solute Carrier Family 16 Member 1	Protein Coding	32.58	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Proteins (show sections)	17701893
14	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	31.23	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
15	INS	Insulin	Protein Coding	30.65	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	10975210 9162611 18484562 (more) 11544612 7895957 19366775 11012567 10934454 11220353 14585087 1932902 18715200 16025296 1956736 1830533 10971447 10969839 17285009 15855577 19178524 12831635 8443479 2272633 15356061 15901524 8840097 1351127 1678798 18083783 15375778 12610018 11430183 19318387 17521012 16569758 9773738 9113474 7895456 16374162 15209772 20200307 17415551 15734853 10910009 11460588 7743760 16249541 1954812 19440117 15551297 12734137 2237055 10778865 10392347 10669122 9368685 7988782 7983527 8029194 1826237 2184211 19436668 19024537 18959604 17023087 12610006 9932217 8884164 8136620 8299480 1979763 2192194 1932903 19670374 15671916 11926785 19667675 12371641 11225967 9255188 7586616 8485954 2194712 19623047 16175061 10523009 9135698 7523002 2198433 19707744 11315820 9096968 8425662 1430091 2224606 17916634 17550216 12174321 9141533
16	ACADVL	Acyl-CoA Dehydrogenase Very Long Chain	Protein Coding	30.14	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications (show sections)	16199475 16435213 17206456 (more) 12359260 8809347 16621643 19156135 16880373 15025677 19208414 11433098 15845636
17	CRH	Corticotropin Releasing Hormone	Protein Coding	29.35	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Summaries (show sections)	7586616 1309389 1331166 (more) 1966026 8582421 9203994 1400870 1285360 7496087 15879359 9558010 9483705 1648460 7556777 8327371 8386766 10811293 9652904 7704086 1966779 16669599 16266629 11788380 11779371 10939538 8582717 1322422 9676772 8817725 11197891 1323248 8706296 8835601
18	AGL	Amylo-Alpha-1, 6-Glucosidase, 4-Alpha-Glucanotransferase	Protein Coding	29.03	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications (show sections)	8990006 18717245 19951495 (more) 17895567
19	CPT1A	Carnitine Palmitoyltransferase 1A	Protein Coding	28.42	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications (show sections)	16870691 11286380 15669684 (more) 10407779 16602102 12189492 14517221
20	CPT2	Carnitine Palmitoyltransferase 2	Protein Coding	28.17	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications (show sections)	18471680 1999498 12410208
21	HYOU1	Hypoxia Up-Regulated 1	Protein Coding	27.4	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
22	ACADL	Acyl-CoA Dehydrogenase Long Chain	Protein Coding	26.95	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Summaries (show sections)	1945557 9861014 8517612
23	PCK2	Phosphoenolpyruvate Carboxykinase 2, Mitochondrial	Protein Coding	26.01	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications (show sections)	19821526 10599987 17456789 (more) 8932991
24	DPP4	Dipeptidyl Peptidase 4	Protein Coding	25.41	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	18641927 19444259 19820277 (more) 19170358 11394909 16855072 17160910 20107298 20206728 20463416 20519186 16629719 17300591 16338283 17593274 19555131 19940419
25	IGF2	Insulin Like Growth Factor 2	Protein Coding	24.39	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	1281841 19259766 9790231 (more) 2170553 2205424 10586596 8021581 18490836 8760024 10931103 14709848 7545698 7525443 1792643 16860583 19383775 11334396 7524924 10468998 8082393 9773947 2086202 9876347 7685912 11149628 9737571 7724120 2159026 15626921 7715546 7688378 2256261 11518119 8772589 8205358 20527023 16490691 19349855 16682842 9236865 18552458 9589464 8772551 8759187 7514593 8204962 9758443 1716259 1311795 1318326 9709962 7989458 1320177 1720806 19387873 16170199 11777215 9647037 9628278 9113488 19624411 17299065 16935145 15575249 10725783 10674040 9854213 9340344 9046989 8710034 7750199 8929651 1618998 19502525 16227169 15227844 11549873 10633872 9554538 7658270 7771502 20340008 18045950 16882067 15727393 15223980 12324491 9849819 9095642 1635777 1718747 19407853 19673425 8950621 7476305 12606521 7525121 15251701 16981978
26	SST	Somatostatin	Protein Coding	23.85	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	15855577 11334393 1673342 (more) 12547550 8093619 1915515 7904782 8903503 10672712 16949024 9445586 8421084 2113855 10883468 8410522 2159483 9364348 2184212 17124362 1976218 2185966 19409239 12200764 11840663 9828742 9401640 8772551 8095006 16284426 1493086 2035626 1350344 1674642 1901390 1671783 2106191 17490935 16284444 11834428 11704779 9681860 17047390 1970540 1904602 1889145 12602474
27	HADHB	Hydroxyacyl-CoA Dehydrogenase Trifunctional Multienzyme Complex Subunit Beta	Protein Coding	23.71	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications (show sections)	19417036
28	IGF1	Insulin Like Growth Factor 1	Protein Coding	23.68	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	18644070 17299065 2205424 (more) 15898344 16449027 16548790 7679407 16610982 9849819 1792643 2027818 20081321 7523002 7536210 8088711 17380212 11956148 8300052 9267949 15251701 1311795 7525121 19946434 7514593 8772589 7486340 2033287 2239085 19128470 12213663 7735377 7525624 7518727 9046989 8174311 8243878 1295817 1377706 7966079 19470629 19387873 2183688 18825882 18376417 18419060 16682842 12870155 10435054 9329386 7920992 8498545 2170553 11306751 11308044 15579776 11549873 10487673 9626125 9492063 8928757 7545698 7771502 12030603 9701698 9496559 9113488 7476318 7957405 1403403 7509217 1490658 1379258 16843952 17483375 15001620 11508780 8854134 8300055 7599690 7512681 18952825 16981978 14601488 12968060
29	GYS1	Glycogen Synthase 1	Protein Coding	23.66	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications (show sections)	8635676 8200993
30	POMC	Proopiomelanocortin	Protein Coding	23.26	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	9781630 10523009 8706296 (more) 8222297 1285360 8931651 15070935 8136620 8389624 8393257 1314144 1963505 8835601 15670199 7704086 8105958 16105961 8304539 19303962 15690314 9558010 9088894 8817725 8582717 7594236 1648460 11085187 8582421 8327371 2168434 9766253 8386590 1314020 2164280 10848884 10751014 16483876 15879359 11148335 12812307 18653285 19998238 1323248
31	GLP1R	Glucagon Like Peptide 1 Receptor	Protein Coding	23.03	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	19318378 19444259 19624785 (more) 19801361 19744422 20107301
32	HADHA	Hydroxyacyl-CoA Dehydrogenase Trifunctional Multienzyme Complex Subunit Alpha	Protein Coding	22.29	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders (show sections)	7846063 17143551 10638050 (more) 10352164 2044590 16163656 9403664 15845636 18408953
33	SLC22A5	Solute Carrier Family 22 Member 5	Protein Coding	21.91	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Summaries (show sections)
34	IGFBP3	Insulin Like Growth Factor Binding Protein 3	Protein Coding	21.81	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	9849819 1376980 8772589 (more) 7545698 16449027 11956148 16610982 1716259 1697608 16682842 16548790 7476318 9496559 11549873 7512681 7525121 8760024 9876347
35	HMGCL	3-Hydroxy-3-Methylglutaryl-CoA Lyase	Protein Coding	21.61	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders (show sections)	8440722 2225463 19932602 (more) 8617516 7479590
36	IAPP	Islet Amyloid Polypeptide	Protein Coding	21.6	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	16492545 1787825 16492543 (more) 8772580 16629719 12534323 10866048 9212322
37	GH1	Growth Hormone 1	Protein Coding	21.52	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	2108186 8772589 17201814 (more) 16886962 18248651 15644398 1697608 8119670 12531744 8300052 8077335 9851789 16254436 15799216 10155148 1874023 15579776 15163333 8787278 1617799 1902484 10435054 9702443 9329386 1646698 9046989 9076339 18407098 15473884 7962328 11701703 8300055 11167924 15251557 12812307
38	SLC37A4	Solute Carrier Family 37 Member 4	Protein Coding	21.33	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders (show sections)	17354259 17478431
39	PCK1	Phosphoenolpyruvate Carboxykinase 1	Protein Coding	21.15	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
40	PYGL	Glycogen Phosphorylase L	Protein Coding	20.82	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Summaries (show sections)
41	PRL	Prolactin	Protein Coding	20.72	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	2194712

Hypoglycemia

Aliases & Classifications for Hypoglycemia

MalaCards integrated aliases for Hypoglycemia:

Classifications:

External Ids:

Summaries for Hypoglycemia

Related Diseases for Hypoglycemia

Diseases related to Hypoglycemia via text searches within MalaCards or GeneCards Suite gene sharing:

Comorbidity relations with Hypoglycemia via Phenotypic Disease Network (PDN): (show all 30)

Graphical network of the top 20 diseases related to Hypoglycemia:

Symptoms & Phenotypes for Hypoglycemia

UMLS symptoms related to Hypoglycemia:

GenomeRNAi Phenotypes related to Hypoglycemia according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Hypoglycemia:

Drugs & Therapeutics for Hypoglycemia

Drugs for Hypoglycemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Cochrane evidence based reviews: hypoglycemia

Genetic Tests for Hypoglycemia

Genetic tests related to Hypoglycemia:

Anatomical Context for Hypoglycemia

MalaCards organs/tissues related to Hypoglycemia:

Publications for Hypoglycemia

Articles related to Hypoglycemia:

Genes for Hypoglycemia

Genes related to Hypoglycemia (1 elite genes):

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :