MCID: HYP056
MIFTS: 63

Hypoglycemia

Categories: Blood diseases, Endocrine diseases, Metabolic diseases

Aliases & Classifications for Hypoglycemia

MalaCards integrated aliases for Hypoglycemia:

Name: Hypoglycemia 12 76 29 55 6 43 44 15 73
Hypoglycaemia 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:9993
ICD10 33 E16.2
ICD9CM 35 251.2
MeSH 44 D007003
NCIt 50 C3126
SNOMED-CT 68 66694000
UMLS 73 C0020615

Summaries for Hypoglycemia

MedlinePlus : 43 Hypoglycemia means low blood glucose, or blood sugar. Your body needs glucose to have enough energy. After you eat, your blood absorbs glucose. If you eat more sugar than your body needs, your muscles, and liver store the extra. When your blood sugar begins to fall, a hormone tells your liver to release glucose. In most people, this raises blood sugar. If it doesn't, you have hypoglycemia, and your blood sugar can be dangerously low. Signs include Hunger Shakiness Dizziness Confusion Difficulty speaking Feeling anxious or weak In people with diabetes, hypoglycemia is often a side effect of diabetes medicines. Eating or drinking something with carbohydrates can help. If it happens often, your health care provider may need to change your treatment plan. You can also have low blood sugar without having diabetes. Causes include certain medicines or diseases, hormone or enzyme deficiencies, and tumors. Laboratory tests can help find the cause. The kind of treatment depends on why you have low blood sugar. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Hypoglycemia, also known as hypoglycaemia, is related to hyperinsulinemic hypoglycemia, familial, 3 and hyperinsulinemic hypoglycemia, familial, 7, and has symptoms including sugar craving An important gene associated with Hypoglycemia is G6PC (Glucose-6-Phosphatase Catalytic Subunit), and among its related pathways/superpathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs Diazoxide and Insulin Aspart have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and liver, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 A glucose metabolism disease that is characterized by abnormally low levels of blood glucose.

Wikipedia : 76 Hypoglycemia, also known as low blood sugar, is when blood sugar decreases to below normal levels. This... more...

Related Diseases for Hypoglycemia

Diseases related to Hypoglycemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 548)
# Related Disease Score Top Affiliating Genes
1 hyperinsulinemic hypoglycemia, familial, 3 34.1 ABCC8 G6PC GCK
2 hyperinsulinemic hypoglycemia, familial, 7 34.1 GCG INS SLC16A1
3 hyperinsulinemic hypoglycemia, familial, 6 34.1 GLUD1 HADH INS
4 hyperinsulinemic hypoglycemia 33.4 ABCC8 GCK GLUD1 HADH INS INSR
5 fasting hypoglycemia 33.2 ACADM CRH GLUD1 GYS2 INSR
6 hirata disease 32.9 ABCC8 GCG INS
7 fructose-1,6-bisphosphatase deficiency 32.3 FBP1 G6PC GCG
8 carnitine palmitoyltransferase ii deficiency, infantile 32.2 ACADVL CPT1A CPT2 SLC25A20
9 glycogen storage disease type 0 32.1 AGL GYS2
10 insulinomatosis and diabetes mellitus 32.1 ABCC8 INS
11 carnitine-acylcarnitine translocase deficiency 31.9 CPT1A CPT2 SLC25A20
12 hyperinsulinism 31.8 ABCC8 GCK GLUD1 HADH INS INSR
13 epiphyseal dysplasia, multiple, with early-onset diabetes mellitus 31.7 ABCC8 KCNJ11
14 glycogen storage disease iii 31.6 AGL G6PC GCG
15 long-chain 3-hydroxyacyl-coa dehydrogenase deficiency 31.4 ACADM ACADVL HADH
16 carnitine deficiency, systemic primary 31.4 ACADVL CPT2 SLC25A20
17 acyl-coa dehydrogenase, very long-chain, deficiency of 31.3 ACADVL CPT2 HADH SLC25A20
18 carnitine palmitoyltransferase i deficiency 31.0 ACADVL CPT1A CPT2 HADH SLC25A20
19 insulinoma 30.9 ABCC8 GCG GCK INS
20 3-hydroxyacyl-coa dehydrogenase deficiency 30.9 ACADM ACADVL GCK GLUD1 HADH INS
21 diabetes mellitus 30.8 ABCC8 AKT2 GCG GCK INS INSR
22 hyperglycemia 30.4 ABCC8 G6PC GCG GCK INS INSR
23 diabetes mellitus, noninsulin-dependent 30.3 ABCC8 AKT2 G6PC GCG GCK INS
24 insulin-like growth factor i 30.2 AKT2 INS INSR
25 monocarboxylate transporter 1 deficiency 30.2 GLUD1 INS SLC16A1
26 maturity-onset diabetes of the young 30.1 ABCC8 GCG GCK INS KCNJ11
27 neonatal diabetes mellitus 30.0 ABCC8 GCK INS KCNJ11
28 gestational diabetes 30.0 GCK INS INSR KCNJ11
29 diabetes mellitus, transient neonatal, 1 30.0 ABCC8 INS KCNJ11
30 munchausen by proxy 29.7 ABCC8 GCK KCNJ11
31 monogenic diabetes 29.6 ABCC8 GCK INS KCNJ11
32 glucose intolerance 29.5 GCG GCK INS INSR
33 sheehan syndrome 29.3 CRH INS
34 hyperinsulinemic hypoglycemia, familial, 1 12.7
35 hyperinsulinemic hypoglycemia, familial, 2 12.6
36 hyperinsulinemic hypoglycemia, familial, 5 12.6
37 hypoglycemia, leucine-induced 12.5
38 hyperinsulinemic hypoglycemia, familial, 4 12.5
39 hypoinsulinemic hypoglycemia with hemihypertrophy 12.3
40 hypoketonemic hypoglycemia 12.0
41 glycogen storage disease 0, liver 12.0
42 adult-onset non-insulinoma persistent hyperinsulinemic hypoglycemia 12.0
43 glycogen storage disease ia 11.4
44 3-hydroxy-3-methylglutaryl-coa lyase deficiency 11.3
45 beckwith-wiedemann syndrome 11.3
46 galactosemia 11.3
47 diabetes mellitus, insulin-dependent 11.2
48 fructose intolerance, hereditary 11.1
49 silver-russell syndrome 11.1
50 familial glucocorticoid deficiency 11.1

Comorbidity relations with Hypoglycemia via Phenotypic Disease Network (PDN): (show all 33)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alzheimer Disease
Benign Essential Hypertension Bronchitis
Cerebral Atherosclerosis Chronic Kidney Failure
Chronic Myocardial Ischemia Decubitus Ulcer
Deficiency Anemia Diabetic Polyneuropathy
Encephalopathy Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Hypoglycemic Coma Hypothyroidism
Intermediate Coronary Syndrome Iron Deficiency Anemia
Ischemic Heart Disease Kidney Disease
Microvascular Complications of Diabetes 1 Microvascular Complications of Diabetes 7
Mitral Valve Disease Peripheral Vascular Disease
Protein-Energy Malnutrition Respiratory Failure
Schizophreniform Disorder Sinoatrial Node Disease
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Hypoglycemia:



Diseases related to Hypoglycemia

Symptoms & Phenotypes for Hypoglycemia

UMLS symptoms related to Hypoglycemia:


sugar craving

GenomeRNAi Phenotypes related to Hypoglycemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.41 AKT2 GCK INSR
2 Decreased viability GR00221-A-2 10.41 CPT2 GCK INSR
3 Decreased viability GR00221-A-3 10.41 AKT2 GCK INSR
4 Decreased viability GR00221-A-4 10.41 AKT2 CPT2 GCK INSR
5 Decreased viability GR00231-A 10.41 GCK
6 Decreased viability GR00301-A 10.41 AKT2
7 Decreased viability GR00342-S-3 10.41 AKT2
8 Decreased viability GR00402-S-2 10.41 ABCC8 ACADM ACADVL AGL AKT2 CPT1A
9 no effect GR00402-S-1 9.96 ABCC8 ACADM ACADVL AGL AKT2 CPT1A
10 shRNA abundance <= 50% GR00343-S 9.32 ACADM ACADVL AGL CPT2 FBP1 G6PC

MGI Mouse Phenotypes related to Hypoglycemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 ABCC8 ACADM ACADVL AGL AKT2 CPT1A
2 growth/size/body region MP:0005378 10.11 ACADVL AKT2 CRH G6PC GCK GLUD1
3 endocrine/exocrine gland MP:0005379 10.1 ABCC8 AKT2 CRH GCK GLUD1 HADH
4 cardiovascular system MP:0005385 10.09 ACADM ACADVL CPT1A CPT2 GYS2 INS
5 adipose tissue MP:0005375 10.06 ACADVL AKT2 CRH HADH INS INSR
6 liver/biliary system MP:0005370 10.03 ACADM ACADVL AGL AKT2 CRH G6PC
7 mortality/aging MP:0010768 9.97 ACADM ACADVL AGL AKT2 CPT1A CPT2
8 muscle MP:0005369 9.56 ACADM ACADVL AGL AKT2 GYS2 INS
9 renal/urinary system MP:0005367 9.17 CRH G6PC GCK HADH INS INSR

Drugs & Therapeutics for Hypoglycemia

Drugs for Hypoglycemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 618)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diazoxide Approved Phase 4,Phase 2,Phase 3,Phase 1 364-98-7 3019
2
Insulin Aspart Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 116094-23-6 16132418
3
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7440-66-6
4
Glyburide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 10238-21-8 3488
5
Pancrelipase Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 53608-75-6
6
Saxagliptin Approved Phase 4,Phase 3,Phase 2,Phase 1 361442-04-8 11243969
7
Glipizide Approved, Investigational Phase 4,Phase 3,Not Applicable 29094-61-9 3478
8
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 657-24-9 14219 4091
9
Insulin Detemir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 169148-63-4 5311023
10
Insulin Glargine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 160337-95-1
11
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 94-09-7, 1994-09-7 2337
12 tannic acid Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
13
Somatostatin Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 51110-01-1, 38916-34-6 53481605
14
Octreotide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83150-76-9 383414 6400441
15 lanreotide Approved Phase 4 108736-35-2
16
Insulin Lispro Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 133107-64-9
17
Acarbose Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 56180-94-0 441184
18
Glimepiride Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 93479-97-1 3476
19
Exenatide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 141758-74-9 15991534
20
Liraglutide Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 204656-20-2 44147092
21
Insulin glulisine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 207748-29-6
22
Repaglinide Approved, Investigational Phase 4,Phase 3,Phase 2 135062-02-1 65981
23
Ezetimibe Approved Phase 4 163222-33-1 150311
24
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 111025-46-8 4829
25
Vildagliptin Approved, Investigational Phase 4,Phase 3 274901-16-5 6918537
26
Gliclazide Approved Phase 4,Phase 3,Phase 2,Not Applicable 21187-98-4 3475
27
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-23-7 5754
28
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-03-3
29
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 64-17-5 702
30
Pramlintide Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 151126-32-8
31
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9005-49-6 772 46507594
32
Lixisenatide Approved Phase 4,Phase 3,Phase 2 320367-13-3
33
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Not Applicable,Early Phase 1 51-43-4 5816
34
Racepinephrine Approved Phase 4,Phase 2,Not Applicable,Early Phase 1 329-65-7 838
35
Pasireotide Approved Phase 4,Phase 2,Phase 1 396091-73-9 9941444
36
Verapamil Approved Phase 4 52-53-9 2520
37
Aprepitant Approved, Investigational Phase 4 170729-80-3 6918365 151165
38
Fosaprepitant Approved Phase 4 172673-20-0 219090
39
Linagliptin Approved Phase 4,Phase 3,Not Applicable 668270-12-0 10096344
40
Rosiglitazone Approved, Investigational Phase 4,Phase 3,Phase 2 122320-73-4 77999
41
Alogliptin Approved Phase 4,Phase 3,Phase 2 850649-61-5 11450633
42
Simvastatin Approved Phase 4,Phase 3 79902-63-9 54454
43
Gliquidone Approved, Investigational Phase 4 33342-05-1 91610
44
Canagliflozin Approved Phase 4,Phase 3,Phase 2,Phase 1 842133-18-0
45
Doxazosin Approved Phase 4 74191-85-8 3157
46
Phenoxybenzamine Approved Phase 4 59-96-1 4768
47
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 2 93-14-1 3516
48
Nateglinide Approved, Investigational Phase 4 105816-04-4 60026
49
Entecavir Approved, Investigational Phase 4,Phase 3,Phase 2 142217-69-4 153941
50
Spironolactone Approved Phase 4,Not Applicable 52-01-7, 1952-01-7 5833

Interventional clinical trials:

(show top 50) (show all 2326)
# Name Status NCT ID Phase Drugs
1 Lactate and Hypoglycemia Unknown status NCT01387477 Phase 4 Lactate;Glucose
2 Use of Diazoxide in Acute Hypoglycaemia Unknown status NCT01488136 Phase 4 Diazoxide;Placebo
3 Glucose Control During Labour in Gestational Diabetes Mellitus With Insulin Treatment: A Randomized Controlled Trial Unknown status NCT02590016 Phase 4 Insulin, Aspart
4 Do Sulphonylureas Preserve Cortical Function During Hypoglycaemia? Unknown status NCT00472875 Phase 4 Glibenclamide
5 Treatment of Low Blood Sugar With Glucagon Among Patients With Type 1 Diabetes Unknown status NCT02232971 Phase 4 Glucagon
6 Outpatient Discharge Therapy With Saxagliptin+MetforminXR vs GlipizideXL for Type 2 Diabetes With Severe Hyperglycemia Unknown status NCT01267448 Phase 4 Glipizide XL;Saxagliptin + Metformin XR;Metformin XR
7 Glucometer and Mobile-phone Based Data Transfer System in Diabetes Unknown status NCT02769377 Phase 4
8 Comparing Long-acting Insulins During Exercise in Type 1 Diabetes Unknown status NCT01440439 Phase 4 Insulin glargine;Insulin detemir
9 Real-Time Continuous Glucose Monitoring in Pre-School Children With Type-1 Diabetes Mellitus Unknown status NCT01016457 Phase 4
10 Intensive Insulin Therapy for Strict Glycemic Control in Neurosurgical Patients: Safety and Efficacy Unknown status NCT00505505 Phase 4 Insulin (Actrapid)
11 Lanreotide Autogel Treatment of Patients With Congenital Hyperinsulinism of Infancy Unknown status NCT01070758 Phase 4 Lanreotide autogel
12 Metformin and Sitagliptin Therapy for Adult Patients With Type 2 Diabetes Admitted to the General Medical Unit Unknown status NCT02250794 Phase 4 metformin and sitagliptin;insulin glargine and insulin lispro;metformin and sitagliptin;insulin glargine and insulin lispro
13 Long-Term Sulfonylurea Response in ABCC8 Neonatal Diabetes (SuResponsSUR) Unknown status NCT02624830 Phase 4 Sulfonylurea
14 Substitution of First Phase Insulin Response in Patient With Type 2 Diabetes. Unknown status NCT00254085 Phase 4 Insulin Aspart
15 Saxagliptin's Effects on Microalbuminuria Improvement in Type 2 Diabetic Patients Unknown status NCT02462369 Phase 4 Saxagliptin;glimepiride
16 Effect of an Artificial Pancreas in Patients Undergoing Pancreatic Resection Unknown status NCT00661648 Phase 4
17 Endobarrier Treatment in Obese Subjects With T2DM Unknown status NCT01718457 Phase 4
18 Exenatide Compared With Insulin Glargine to Change Liver Fat Content in Type 2 Diabetes Unknown status NCT02303730 Phase 4 Exenatide;insulin glargine
19 GLP-1 Analogue Treatment in Uncontrolled Type 1 Diabetic Patients Unknown status NCT01592279 Phase 4 liraglutide;Insulin injections
20 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics Unknown status NCT00845936 Phase 4 Metformin
21 Organization Program of DiabEtes INsulIN ManaGement Unknown status NCT01338376 Phase 4 Scilin®M30
22 Insulin Requirement for Pure-protein Meal in Children With Type 1 Diabetes on Insulin Pumps. Unknown status NCT02685449 Phase 4 Insulin glulisine;Insulin aspart;Insulin lispro
23 A Double-Blind, Randomized, Parallel, Comparative Study to Evaluate the Efficacy and Safety of an Antidiabetic Agent Repaglinide for the Treatment of Type 2 Diabetes Mellitus Patients Unknown status NCT00336310 Phase 4 Repaglinide
24 Randomized Trial Comparing Colesevelam vs. Ezetimibe Unknown status NCT02682680 Phase 4 Colesevelam;Ezetimibe
25 Compare the Effect of DPP-IV Inhibitor or TZD on Glycemic Variability and Oxidative Stress in Patient With 2 Diabetes Unknown status NCT01339143 Phase 4 Galvus (vildagliptin);pioglitazone
26 Exploratory Study to Compare the Effects of Tenelia® or Januvia® on Glucose Variability in add-on to Metformin (CGMS Study) Unknown status NCT02512523 Phase 4 Teneligliptin;Sitagliptin
27 Comparison of Glycaemic Fluctuation and Oxidative Stress Between Two Short-term Therapies for Type 2 Diabetes Unknown status NCT02526810 Phase 4 insulin lispro;Insulin Glargine
28 Comparison Study of Insulin Glargine and NPH Insulin Unknown status NCT01854723 Phase 4 Switching to NPH insulin;Continuation of insulin glargine
29 Continuous Subcutaneous Insulin Infusion strAtegy Versus Multiple Daily Insulin Injections strAtegy Unknown status NCT01574508 Phase 4 Transient Continuous Subcutaneous Insulin Infusion;Transient Multiple Daily Insulin Injections
30 Insulin NovoRapid Versus Actrapid in Treatment of Type 1 Diabetic Patients During Daily Adjustment of Insulin Dose Unknown status NCT00145353 Phase 4 Insulin NovoRapid versus Actrapid
31 Oral Antidiabetic Agents in Pregnancy Unknown status NCT02091336 Phase 4 Metformin;Glyburide
32 Syringes Replacement for Insulin Application for Pens Device in a Population of Elderly Patients With Type 2 Diabetes: Multifactorial Intervention to Improve Glycemic Control Unknown status NCT02517242 Phase 4
33 Effect on Beta Cell Function and Glycaemic Control After Insulin and Exenatide Sequential Therapy Unknown status NCT02129985 Phase 4 Exenatide;Metformin
34 Clinical Study to Compare Various Dosing and Titration Guidelines of Insulin Delivered Via V-Go ® in Patients With Type 2 Diabetes Initiating Basal Bolus Therapy in Primary Care Offices Unknown status NCT02361489 Phase 4
35 Effect of Anti-diabetic Drugs on Glycemic Variability Unknown status NCT02925559 Phase 4 Dapagliflozin;Gliclazide MR
36 Probiotics in Newly Recognized Type 1 Diabetes Unknown status NCT03032354 Phase 4 Lactobacillus rhamnosus GG and Bifidobacterium lactis BB12
37 Effect of SGLT-2 Inhibitor Dapagliflozin on Glycemic Variability in Patients With Diabetes Mellitus Type 2 Unknown status NCT02719756 Phase 4 Metformin;Dapagliflozin;Metformin up-titration
38 Preventing Recurrent Gestational Diabetes With Metformin Unknown status NCT02394158 Phase 4 Metformin;placebo
39 Human Insulin Analogs: Evaluation of Inflammatory mRNA Expression of Macrophages and Endothelial Function of Short-acting Insulin - HERMES Pilot Study Unknown status NCT01417897 Phase 4 Insulin glulisine;Insulin aspart;Regular human insulin
40 The Therapeutic Effects of Insulin and Berberine on Stress Hyperglycemia Unknown status NCT02806999 Phase 4 Berberine; Insulin;Insulin
41 Study on Lixisenatide and Counterregulation to Hypoglycemia Completed NCT02020629 Phase 4 Lixisenatide
42 Vildagliptin and the Glucagon Response to Hypoglycemia in Insulin-Treated Patients With Type 2 Diabetes Completed NCT01219400 Phase 4 Vildagliptin
43 Vildagliptin and the Glucagon Response to Hypoglycemia in Type 1 Diabetes Completed NCT01147276 Phase 4 Vildagliptin
44 Insulin Analogues and Severe Hypoglycaemia Completed NCT00346996 Phase 4 insulin levemir / aspart;human insulin /insulin isophane
45 Treatment With Sitagliptin for Reactive Hypoglycemia Secondary to Dysinsulinism Completed NCT00847080 Phase 4 Sitagliptin phosphate;Placebo
46 Investigating the Accuracy of the Home Glucose Monitors in Hypoglycemia Completed NCT01013402 Phase 4 Human insulin;Human Insulin
47 Treatment of Hypoglycemia Following Gastric Bypass Surgery Completed NCT02527993 Phase 4 Glucobay (acarbose);Januvia (sitagliptin);Verapamil HEXAL (verapamil);Victoza (liraglutide);Signifor (pasireotide)
48 Prevention of Severe Hypoglycemia in Type 1 Diabetes Completed NCT00360984 Phase 4 insulin glargine
49 Continuous Glucose Monitoring and Preterm Infants Completed NCT02583776 Phase 4
50 Sitagliptin and Glucagon Counterregulation Completed NCT02256189 Phase 4 Sitagliptin;Placebo

Search NIH Clinical Center for Hypoglycemia

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: hypoglycemia

Genetic Tests for Hypoglycemia

Genetic tests related to Hypoglycemia:

# Genetic test Affiliating Genes
1 Hypoglycemia 29

Anatomical Context for Hypoglycemia

MalaCards organs/tissues related to Hypoglycemia:

41
Testes, Brain, Liver, Kidney, Pancreas, Heart, Endothelial

Publications for Hypoglycemia

Articles related to Hypoglycemia:

(show top 50) (show all 3574)
# Title Authors Year
1
Hypoglycemia induced by Plasmodium berghei infection is prevented by treatment with Tinospora crispa stem extract. ( 30343056 )
2019
2
Closed-loop driven by control-to-range algorithm outperforms threshold-low-glucose-suspend insulin delivery on glucose control albeit not on nocturnal hypoglycaemia in prepubertal patients with type 1 diabetes in a supervised hotel setting. ( 30047223 )
2019
3
Admissions for hypoglycaemia after 35 weeks of gestation: perinatal predictors of cost of stay. ( 28922987 )
2019
4
Severe fasting hypoglycemia in a child after total pancreatectomy with islet autotransplantation. ( 29139589 )
2018
5
Insulin Detemir Use Is Associated With Higher Occurrence of Hypoglycemia in Hospitalized Patients With Hypoalbuminemia. ( 29437697 )
2018
6
Neonatal hyperinsulinemic hypoglycemia in a patient with 9p deletion syndrome. ( 29601900 )
2018
7
Association of Initiation of Basal Insulin Analogs vs Neutral Protamine Hagedorn Insulin With Hypoglycemia-Related Emergency Department Visits or Hospital Admissions and With Glycemic Control in Patients With Type 2 Diabetes. ( 29936529 )
2018
8
Hypoglycemia, Cardiovascular Outcomes, and Death: The LEADER Experience. ( 29903847 )
2018
9
CORRIGENDUM FOR &amp;quot;Novel Hypoglycemia Phenotype in Congenital Hyperinsulinism Due to Dominant Mutations of Uncoupling Protein 2&amp;quot;. ( 29538671 )
2018
10
Hypoglycemia and lactic acidosis outperform King's College criteria for predicting death or transplant in acetaminophen toxic patients. ( 29301418 )
2018
11
Giant umbilical cord and hypoglycemia in an infant with Proteus syndrome. ( 29681107 )
2018
12
Hypoglycemia in a Patient With a Polyhormonal Pancreatic Neuroendocrine Tumor With Evidence of Endocrine Progenitors. ( 29568813 )
2018
13
Stable Liquid Glucagon: Beyond Emergency Hypoglycemia Rescue. ( 29415555 )
2018
14
Prevalence and predictors of hypoglycemia in South Korea. ( 29939502 )
2018
15
Association of ADHD with recurrent hypoglycemia in type 1 DM. ( 29938875 )
2018
16
Different Indexes of Glycemic Variability as Identifiers of Patients with Risk of Hypoglycemia in Type 2 Diabetes Mellitus. ( 29451006 )
2018
17
A unique allosteric insulin receptor monoclonal antibody that prevents hypoglycemia in the SUR-1<sup>-/-</sup> mouse model of KATP hyperinsulinism. ( 29589989 )
2018
18
A Quality-Improvement Initiative to Reduce NICU Transfers for Neonates at Risk for Hypoglycemia. ( 29437908 )
2018
19
Costello Syndrome: The Challenge of Hypoglycemia and Failure to Thrive. ( 29248509 )
2018
20
Detection of asymptomatic drug-induced hypoglycemia using continuous glucose monitoring in older people - Systematic review. ( 29887300 )
2018
21
Does reactive hypoglycemia during the 100 g oral glucose tolerance test adversely affect perinatal outcomes? ( 29411343 )
2018
22
Severe insulin resistance in disguise: A familial case of reactive hypoglycemia associated with a novel heterozygous INSR mutation. ( 29411486 )
2018
23
Avoiding Hypoglycemia: The use of Insulin Pump combined with Continuous Glucose Monitor in Type 1 Diabetes Crossing a Rocky Gorge. ( 29939323 )
2018
24
Poor Sleep Quality is Associated with Nocturnal Glycemic Variability and Fear of Hypoglycemia in Adults with Type 1 Diabetes. ( 29917259 )
2018
25
Individuals with Type 1 and Type 2 Diabetes Mellitus Trade Increased Hyperglycemia for Decreased Hypoglycemia When Glycemic Variability is not Improved. ( 29164512 )
2018
26
Diazoxide toxicity in a child with persistent hyperinsulinemic hypoglycemia of infancy: mixed hyperglycemic hyperosmolar coma and ketoacidosis. ( 29958183 )
2018
27
No answers yet for the prevention of neonatal hypoglycemia. ( 29936962 )
2018
28
A novel homozygous mutation in the mannose phosphate isomerase gene causing congenital disorder of glycation and hyperinsulinemic hypoglycemia in an infant. ( 29531722 )
2018
29
The Effect of Everolimus on Refractory Hypoglycemia in a Patient with Inoperable Metastatic Insulinoma Evaluated by Continuous Glucose Monitoring. ( 29877259 )
2018
30
Acquired Chiari I Malformation Secondary to Spontaneous Intracranial Hypotension Syndrome and Persistent Hypoglycemia: A Case Report. ( 29513222 )
2018
31
HbA<sub>1c</sub> and Hypoglycemia Reductions at 24 and 52 Weeks With Sotagliflozin in Combination With Insulin in Adults With Type 1 Diabetes: The European inTandem2 Study. ( 29937431 )
2018
32
Quality-of-life and treatment satisfaction in actual clinical practice of patients with Type 1 diabetes mellitus (T1DM) and hypoglycemia treated with insulin degludec. ( 29300101 )
2018
33
Severe hypoglycemia is associated with high risk for falls in adults with type 1 diabetes. ( 29892791 )
2018
34
Hypoglycemia and cognitive function in diabetic patients. ( 29887517 )
2018
35
Intentional overdose of liraglutide in a non-diabetic patient causing severe hypoglycemia. ( 29397808 )
2018
36
Roux en Y gastric bypass hypoglycemia resolves with gastric feeding or reversal: Confirming a non-pancreatic etiology. ( 29449181 )
2018
37
Exposure to hypoglycemia and risk of stroke. ( 29917249 )
2018
38
Recurrent lactic acidosis and hypoglycemia with inadvertent metformin use: a case of look-alike pills. ( 29340159 )
2018
39
A case of CHARGE syndrome associated with hyperinsulinemic hypoglycemia in infancy. ( 29355723 )
2018
40
Severe lactic acidosis and hypoglycemia due to acute metformin intoxication in a dog. ( 29687945 )
2018
41
Reduced Glucose Variability With Glucose-Dependent Versus Glucose-Independent Therapies Despite Similar Glucose Control and Hypoglycemia Rates in a Randomized, Controlled Study of Older Patients With Type 2 Diabetes Mellitus. ( 29893144 )
2018
42
Recurrent non-severe hypoglycemia exacerbates imbalance of mitochondrial homeostasis leading to synapse injury and cognitive deficit in diabetes. ( 29969317 )
2018
43
Agraphia with reversible splenial corpus callosum lesion caused by hypoglycemia. ( 29606344 )
2018
44
Short communication: Cow- and herd-level prevalence of hypoglycemia in hyperketonemic postpartum dairy cows. ( 29428744 )
2018
45
Ketotic Hypoglycemia in Children with Previous Transient Congenital Hyperinsulinism. ( 29503277 )
2018
46
Relationship between Blood Glucose Fluctuation and Brain Damage in the Hypoglycemia Neonates. ( 29444533 )
2018
47
Glial acetate metabolism is increased following a 72-h fast in metabolically healthy men and correlates with susceptibility to hypoglycemia. ( 29931424 )
2018
48
Can reversal of RYGB also reverse hypoglycemia? ( 29371089 )
2018
49
Lower objectively measured physical activity is linked with perceived risk of hypoglycemia in type 1 diabetes. ( 29937138 )
2018
50
Second-Generation Antipsychotic-Induced Hypoglycemia. ( 29372938 )
2018

Variations for Hypoglycemia

ClinVar genetic disease variations for Hypoglycemia:

6 (show all 12)
# Gene Variation Type Significance SNP ID Assembly Location
1 SCN9A NM_002977.3(SCN9A): c.1964A> G (p.Lys655Arg) single nucleotide variant Conflicting interpretations of pathogenicity rs121908919 GRCh37 Chromosome 2, 167138296: 167138296
2 SCN9A NM_002977.3(SCN9A): c.1964A> G (p.Lys655Arg) single nucleotide variant Conflicting interpretations of pathogenicity rs121908919 GRCh38 Chromosome 2, 166281786: 166281786
3 G6PC NM_000151.3(G6PC): c.247C> T (p.Arg83Cys) single nucleotide variant Pathogenic rs1801175 GRCh37 Chromosome 17, 41055964: 41055964
4 G6PC NM_000151.3(G6PC): c.247C> T (p.Arg83Cys) single nucleotide variant Pathogenic rs1801175 GRCh38 Chromosome 17, 42903947: 42903947
5 ABCC8 NM_000352.4(ABCC8): c.3517G> A (p.Val1173Met) single nucleotide variant Likely pathogenic rs141322087 GRCh37 Chromosome 11, 17426099: 17426099
6 ABCC8 NM_000352.4(ABCC8): c.3517G> A (p.Val1173Met) single nucleotide variant Likely pathogenic rs141322087 GRCh38 Chromosome 11, 17404552: 17404552
7 KCNJ11 NM_000525.3(KCNJ11): c.185C> G (p.Thr62Arg) single nucleotide variant Likely pathogenic rs1057518775 GRCh38 Chromosome 11, 17387907: 17387907
8 KCNJ11 NM_000525.3(KCNJ11): c.185C> G (p.Thr62Arg) single nucleotide variant Likely pathogenic rs1057518775 GRCh37 Chromosome 11, 17409454: 17409454
9 ABCC8 NM_000352.4(ABCC8): c.1793G> A (p.Arg598Gln) single nucleotide variant Likely pathogenic GRCh38 Chromosome 11, 17430838: 17430838
10 ABCC8 NM_000352.4(ABCC8): c.1793G> A (p.Arg598Gln) single nucleotide variant Likely pathogenic GRCh37 Chromosome 11, 17452385: 17452385
11 ABCC8 NM_000352.4(ABCC8): c.1024G> T (p.Gly342Trp) single nucleotide variant Likely pathogenic rs763028380 GRCh37 Chromosome 11, 17474818: 17474818
12 ABCC8 NM_000352.4(ABCC8): c.1024G> T (p.Gly342Trp) single nucleotide variant Likely pathogenic rs763028380 GRCh38 Chromosome 11, 17453271: 17453271

Expression for Hypoglycemia

Search GEO for disease gene expression data for Hypoglycemia.

Pathways for Hypoglycemia

Pathways related to Hypoglycemia according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 ABCC8 ACADM ACADVL AGL CPT1A CPT2
2
Show member pathways
13.51 AKT2 CPT1A CPT2 GCG INS INSR
3
Show member pathways
12.85 AKT2 FBP1 G6PC GCK GYS2 INS
4
Show member pathways
12.84 ACADM ACADVL CPT1A CPT2 HADH SLC25A20
5
Show member pathways
12.81 AGL FBP1 G6PC GCK GYS2
6
Show member pathways
12.7 ABCC8 AKT2 GCG GCK INS KCNJ11
7
Show member pathways
12.59 AGL FBP1 G6PC GCK GYS2
8
Show member pathways
12.47 AKT2 FBP1 G6PC GYS2 INS INSR
9 12.47 AKT2 CPT1A FBP1 GCG GLUD1 INS
10
Show member pathways
12.36 AKT2 CPT1A FBP1 G6PC GYS2 INS
11
Show member pathways
12.3 ABCC8 GCG INS KCNJ11
12
Show member pathways
12.25 ACADM FBP1 GCK GLUD1
13
Show member pathways
12.17 AKT2 CPT1A CPT2 GYS2 INS INSR
14 12.12 ACADM CPT1A G6PC GCK
15
Show member pathways
12.02 AKT2 G6PC INS INSR
16
Show member pathways
11.96 AGL G6PC GCK GYS2
17
Show member pathways
11.95 GCK INS INSR
18 11.91 AKT2 G6PC INSR
19
Show member pathways
11.87 ABCC8 GCK INS INSR KCNJ11
20 11.84 AKT2 INS INSR
21
Show member pathways
11.84 AKT2 GCK INS
22
Show member pathways
11.84 ACADM ACADVL CPT1A CPT2 HADH
23
Show member pathways
11.84 AKT2 CPT1A G6PC GYS2 INS INSR
24 11.79 ACADM GLUD1 HADH
25 11.68 ACADM CPT1A CPT2
26 11.65 AKT2 CPT1A G6PC
27
Show member pathways
11.62 ACADM ACADVL HADH
28 11.53 AKT2 INS INSR
29 11.51 AKT2 CPT1A FBP1 G6PC GCG GCK
30 11.48 ABCC8 AKT2 CPT1A GYS2 KCNJ11
31 11.41 AKT2 INS INSR
32
Show member pathways
11.36 ACADM ACADVL CPT1A CPT2 HADH SLC25A20
33 11.21 AKT2 INS INSR
34 11.15 ACADM CPT1A CPT2
35 10.92 ABCC8 ACADM ACADVL CPT1A G6PC GCK
36
Show member pathways
10.87 AKT2 INSR
37 10.74 CPT1A CPT2 SLC25A20
38
Show member pathways
10.65 ACADM HADH

GO Terms for Hypoglycemia

Cellular components related to Hypoglycemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule lumen GO:0034774 9.33 AGL GCG INS
2 mitochondrion GO:0005739 9.32 ABCC8 ACADM ACADVL CPT1A CPT2 GCK
3 inward rectifying potassium channel GO:0008282 8.96 ABCC8 KCNJ11

Biological processes related to Hypoglycemia according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.97 ACADM ACADVL CPT1A CPT2 HADH SLC16A1
2 response to drug GO:0042493 9.93 ABCC8 CPT1A CRH HADH KCNJ11
3 metabolic process GO:0008152 9.86 AGL FBP1 GCK GYS2
4 carbohydrate metabolic process GO:0005975 9.85 AKT2 FBP1 GCK INS INSR
5 fatty acid metabolic process GO:0006631 9.83 ACADM ACADVL CPT1A CPT2 HADH
6 cellular response to insulin stimulus GO:0032869 9.8 AKT2 GCK INSR
7 regulation of lipid metabolic process GO:0019216 9.8 ACADM CPT1A CPT2
8 insulin receptor signaling pathway GO:0008286 9.79 AKT2 INS INSR
9 glucose homeostasis GO:0042593 9.77 G6PC GCK INS INSR SLC16A1
10 glycogen metabolic process GO:0005977 9.7 AGL AKT2 G6PC
11 positive regulation of glucose import GO:0046326 9.69 AKT2 INS INSR
12 positive regulation of glucose import in response to insulin stimulus GO:2001275 9.65 AKT2 INS
13 positive regulation of glycolytic process GO:0045821 9.65 INS INSR
14 negative regulation of insulin secretion GO:0046676 9.65 ABCC8 HADH KCNJ11
15 glucose metabolic process GO:0006006 9.65 AKT2 CPT1A GCK INS KCNJ11
16 cellular glucose homeostasis GO:0001678 9.64 ABCC8 GCK
17 positive regulation of calcium ion import GO:0090280 9.64 CRH GCG
18 negative regulation of gluconeogenesis GO:0045721 9.63 GCK INS
19 regulation of gluconeogenesis GO:0006111 9.62 ACADM FBP1
20 glycogen biosynthetic process GO:0005978 9.62 ACADM AGL AKT2 GYS2
21 glycogen catabolic process GO:0005980 9.61 AGL G6PC
22 fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 9.6 ACADM ACADVL
23 glucose 6-phosphate metabolic process GO:0051156 9.59 G6PC GCK
24 neuron projection maintenance GO:1990535 9.58 INS INSR
25 positive regulation of fatty acid beta-oxidation GO:0032000 9.58 AKT2 CPT1A
26 carnitine shuttle GO:0006853 9.58 CPT1A CPT2 SLC25A20
27 carnitine metabolic process GO:0009437 9.57 ACADM CPT1A
28 positive regulation of respiratory burst GO:0060267 9.55 INS INSR
29 positive regulation of glycogen biosynthetic process GO:0045725 9.46 AKT2 GCK INS INSR
30 fatty acid beta-oxidation GO:0006635 9.35 ACADM ACADVL CPT1A CPT2 HADH
31 regulation of insulin secretion GO:0050796 9.1 ABCC8 CPT1A GCG GCK KCNJ11 SLC16A1

Molecular functions related to Hypoglycemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.91 ACADM CPT1A FBP1 GCG GLUD1 INS
2 hormone activity GO:0005179 9.58 CRH GCG INS
3 insulin-like growth factor receptor binding GO:0005159 9.37 INS INSR
4 NAD+ binding GO:0070403 9.32 GLUD1 HADH
5 glucose binding GO:0005536 9.26 GCK GYS2
6 acyl-CoA dehydrogenase activity GO:0003995 9.16 ACADM ACADVL
7 ATP-activated inward rectifier potassium channel activity GO:0015272 8.96 ABCC8 KCNJ11
8 carnitine O-palmitoyltransferase activity GO:0004095 8.62 CPT1A CPT2

Sources for Hypoglycemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....