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MCID: HYP056
MIFTS: 64

Hypoglycemia

Categories: Blood diseases, Endocrine diseases, Metabolic diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Hypoglycemia

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MalaCards integrated aliases for Hypoglycemia:

Name: Hypoglycemia 12 77 30 56 6 44 45 15 74
Hypoglycaemia 12 15

Classifications:

MalaCards categories:
Global: Metabolic diseases
Anatomical: Endocrine diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:9993
ICD9CM 36 251.2
MeSH 45 D007003
NCIt 51 C3126
SNOMED-CT 69 66694000
ICD10 34 E16.2
UMLS 74 C0020615
Sources

Summaries for Hypoglycemia

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MedlinePlus : 44 Hypoglycemia means low blood glucose, or blood sugar. Your body needs glucose to have enough energy. After you eat, your blood absorbs glucose. If you eat more sugar than your body needs, your muscles, and liver store the extra. When your blood sugar begins to fall, a hormone tells your liver to release glucose. In most people, this raises blood sugar. If it doesn't, you have hypoglycemia, and your blood sugar can be dangerously low. Signs include Hunger Shakiness Dizziness Confusion Difficulty speaking Feeling anxious or weak In people with diabetes, hypoglycemia is often a side effect of diabetes medicines. Eating or drinking something with carbohydrates can help. If it happens often, your health care provider may need to change your treatment plan. You can also have low blood sugar without having diabetes. Causes include certain medicines or diseases, hormone or enzyme deficiencies, and tumors. Laboratory tests can help find the cause. The kind of treatment depends on why you have low blood sugar. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Hypoglycemia, also known as hypoglycaemia, is related to hyperinsulinemic hypoglycemia, familial, 3 and hyperinsulinemic hypoglycemia, familial, 6, and has symptoms including sugar craving An important gene associated with Hypoglycemia is G6PC (Glucose-6-Phosphatase Catalytic Subunit), and among its related pathways/superpathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs Pramlintide and Diazoxide have been mentioned in the context of this disorder. Affiliated tissues include pancreas, brain and testes, and related phenotypes are no effect and shRNA abundance <= 50%

Disease Ontology : 12 A glucose metabolism disease that is characterized by abnormally low levels of blood glucose.

Wikipedia : 77 Hypoglycemia, also known as low blood sugar, is when blood sugar decreases to below normal levels. This... more...

Sources

Related Diseases for Hypoglycemia

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Diseases related to Hypoglycemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 649)
# Related Disease Score Top Affiliating Genes
1 hyperinsulinemic hypoglycemia, familial, 3 34.3 ABCC8 G6PC GCK
2 hyperinsulinemic hypoglycemia, familial, 6 34.3 GLUD1 HADH INS
3 hyperinsulinemic hypoglycemia, familial, 7 34.2 GCG INS SLC16A1
4 hyperinsulinemic hypoglycemia 33.3 ABCC8 GCK GLUD1 HADH INS INSR
5 fasting hypoglycemia 33.2 ACADM CRH GLUD1 GYS2 INSR
6 hirata disease 33.1 ABCC8 GCG INS
7 fructose-1,6-bisphosphatase deficiency 32.4 FBP1 G6PC GCG
8 glycogen storage disease type 0 32.4 AGL GYS2
9 insulinomatosis and diabetes mellitus 32.2 ABCC8 INS
10 carnitine palmitoyltransferase ii deficiency, infantile 32.0 ACADVL CPT1A CPT2 SLC25A20
11 epiphyseal dysplasia, multiple, with early-onset diabetes mellitus 31.9 ABCC8 KCNJ11
12 hyperinsulinism 31.8 ABCC8 GCK GLUD1 HADH INS INSR
13 carnitine-acylcarnitine translocase deficiency 31.7 CPT1A CPT2 SLC25A20
14 glycogen storage disease iii 31.7 AGL G6PC GCG
15 long-chain 3-hydroxyacyl-coa dehydrogenase deficiency 31.5 ACADM ACADVL HADH
16 carnitine deficiency, systemic primary 31.2 ACADVL CPT2 SLC25A20
17 insulinoma 31.1 ABCC8 GCG GCK INS
18 acyl-coa dehydrogenase, very long-chain, deficiency of 31.0 ACADVL CPT2 HADH SLC25A20
19 diabetes mellitus 30.8 ABCC8 AKT2 GCG GCK INS INSR
20 3-hydroxyacyl-coa dehydrogenase deficiency 30.8 ACADM ACADVL GCK GLUD1 HADH INS
21 carnitine palmitoyltransferase i deficiency 30.7 ACADVL CPT1A CPT2 HADH SLC25A20
22 hyperglycemia 30.5 ABCC8 G6PC GCG GCK INS INSR
23 gestational diabetes 30.3 GCK INS INSR KCNJ11
24 insulin-like growth factor i 30.3 AKT2 INS INSR
25 maturity-onset diabetes of the young 30.1 ABCC8 GCG GCK INS KCNJ11
26 neonatal diabetes mellitus 30.1 ABCC8 GCK INS KCNJ11
27 diabetes mellitus, transient neonatal, 1 30.1 ABCC8 INS KCNJ11
28 glucose intolerance 30.0 GCG GCK INS INSR
29 munchausen by proxy 29.9 ABCC8 GCK KCNJ11
30 burns 29.8 CRH INS
31 monogenic diabetes 29.7 ABCC8 GCK INS KCNJ11
32 diabetes mellitus, noninsulin-dependent 29.7 ABCC8 AKT2 G6PC GCG GCK INS
33 atrial standstill 1 29.4 ACADVL AGL SLC25A20
34 sheehan syndrome 29.2 CRH INS
35 maturity-onset diabetes of the young, type 1 29.0 ABCC8 AKT2 GCG GCK INS INSR
36 hyperinsulinemic hypoglycemia, familial, 2 12.7
37 hyperinsulinemic hypoglycemia, familial, 1 12.7
38 hyperinsulinemic hypoglycemia, familial, 5 12.6
39 hypoglycemia, leucine-induced 12.6
40 hyperinsulinemic hypoglycemia, familial, 4 12.6
41 hypoinsulinemic hypoglycemia with hemihypertrophy 12.5
42 immunodeficiency 59 and hypoglycemia 12.3
43 hypoketonemic hypoglycemia 12.1
44 glycogen storage disease 0, liver 12.0
45 adult-onset non-insulinoma persistent hyperinsulinemic hypoglycemia 12.0
46 glycogen storage disease ia 11.4
47 3-hydroxy-3-methylglutaryl-coa lyase deficiency 11.4
48 beckwith-wiedemann syndrome 11.3
49 galactosemia 11.3
50 multiple acyl-coa dehydrogenase deficiency 11.3

Comorbidity relations with Hypoglycemia via Phenotypic Disease Network (PDN): (show all 33)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alzheimer Disease
Benign Essential Hypertension Bronchitis
Cerebral Atherosclerosis Chronic Kidney Failure
Chronic Myocardial Ischemia Decubitus Ulcer
Deficiency Anemia Diabetic Polyneuropathy
Encephalopathy Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Hypoglycemic Coma Hypothyroidism
Intermediate Coronary Syndrome Iron Deficiency Anemia
Ischemic Heart Disease Kidney Disease
Microvascular Complications of Diabetes 1 Microvascular Complications of Diabetes 7
Mitral Valve Disease Peripheral Vascular Disease
Protein-Energy Malnutrition Respiratory Failure
Schizophreniform Disorder Sinoatrial Node Disease
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Hypoglycemia:



Diseases related to Hypoglycemia
Sources

Symptoms & Phenotypes for Hypoglycemia

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UMLS symptoms related to Hypoglycemia:


sugar craving

GenomeRNAi Phenotypes related to Hypoglycemia according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.26 ABCC8 ACADM ACADVL AGL AKT2 CPT1A
2 shRNA abundance <= 50% GR00343-S 9.32 ACADM ACADVL AGL CPT2 FBP1 G6PC

MGI Mouse Phenotypes related to Hypoglycemia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 ABCC8 ACADM ACADVL AGL AKT2 CPT1A
2 growth/size/body region MP:0005378 10.11 ACADVL AKT2 CRH G6PC GCK GLUD1
3 endocrine/exocrine gland MP:0005379 10.1 ABCC8 AKT2 CRH GCK GLUD1 HADH
4 cardiovascular system MP:0005385 10.09 ACADM ACADVL CPT1A CPT2 GYS2 INS
5 adipose tissue MP:0005375 10.06 ACADVL AKT2 CRH HADH INS INSR
6 liver/biliary system MP:0005370 10.03 ACADM ACADVL AGL AKT2 CRH G6PC
7 mortality/aging MP:0010768 9.97 ACADM ACADVL AGL AKT2 CPT1A CPT2
8 muscle MP:0005369 9.56 ACADM ACADVL AGL AKT2 GYS2 INS
9 renal/urinary system MP:0005367 9.17 CRH G6PC GCK HADH INS INSR
Sources

Drugs & Therapeutics for Hypoglycemia

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Drugs for Hypoglycemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 665)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pramlintide Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 151126-32-8
2
Diazoxide Approved Phase 4,Phase 2,Phase 3,Phase 1 364-98-7 3019
3
Insulin Aspart Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 116094-23-6 16132418
4
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7440-66-6 32051
5
Glyburide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 10238-21-8 3488
6
Pancrelipase Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 53608-75-6
7
Glucagon Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 16941-32-5
8
Saxagliptin Approved Phase 4,Phase 3,Phase 2,Phase 1 361442-04-8 11243969
9
Glipizide Approved, Investigational Phase 4,Phase 3,Not Applicable 29094-61-9 3478
10
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 657-24-9 14219 4091
11
Insulin Detemir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 169148-63-4 5311023
12
Insulin glargine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 160337-95-1
13
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 1994-09-7, 94-09-7 2337
14
tannic acid Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 1401-55-4
15
Somatostatin Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 38916-34-6, 51110-01-1 53481605
16
Octreotide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83150-76-9 6400441 383414
17
lanreotide Approved Phase 4 108736-35-2
18
Insulin Lispro Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 133107-64-9
19
Acarbose Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 56180-94-0 441184
20
Glimepiride Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 93479-97-1 3476
21
Insulin glulisine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 207748-29-6
22
Exenatide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 141758-74-9 15991534
23
Liraglutide Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 204656-20-2 44147092
24
Repaglinide Approved, Investigational Phase 4,Phase 3,Phase 2 135062-02-1 65981
25
Vildagliptin Approved, Investigational Phase 4,Phase 3 274901-16-5 6918537
26
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 111025-46-8 4829
27
Gliclazide Approved Phase 4,Phase 3,Phase 2,Not Applicable 21187-98-4 3475
28
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-03-3
29
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-23-7 5754
30
Ethanol Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 64-17-5 702
31
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9005-49-6 46507594 772
32
Lixisenatide Approved Phase 4,Phase 3,Phase 2 320367-13-3
33
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Not Applicable,Early Phase 1 51-43-4 5816
34
Racepinephrine Approved Phase 4,Phase 2,Not Applicable,Early Phase 1 329-65-7 838
35
Pasireotide Approved Phase 4,Phase 2,Phase 1 396091-73-9 9941444
36
Verapamil Approved Phase 4 52-53-9 2520
37
gastric inhibitory polypeptide Approved, Investigational Phase 4,Phase 3,Not Applicable,Early Phase 1 100040-31-1
38
Aprepitant Approved, Investigational Phase 4 170729-80-3 6918365 151165
39
Fosaprepitant Approved Phase 4 172673-20-0 219090
40
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2 2921-57-5
41
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2 83-43-2 6741
42
Prednisolone Approved, Vet_approved Phase 4,Phase 2 50-24-8 5755
43
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2 302-25-0
44
Linagliptin Approved Phase 4,Phase 3,Not Applicable 668270-12-0 10096344
45
Rosiglitazone Approved, Investigational Phase 4,Phase 3,Phase 2 122320-73-4 77999
46
Alogliptin Approved Phase 4,Phase 3,Phase 2 850649-61-5 11450633
47
Canagliflozin Approved Phase 4,Phase 3,Phase 2,Phase 1 842133-18-0
48
Simvastatin Approved Phase 4,Phase 3 79902-63-9 54454
49
Ezetimibe Approved Phase 4,Not Applicable 163222-33-1 150311
50
Gliquidone Approved, Investigational Phase 4 33342-05-1 91610

Interventional clinical trials:

(show top 50) (show all 2413)
# Name Status NCT ID Phase Drugs
1 Pramlintide (Symlin) for the Treatment of Hypoglycemia Following Gastric Bypass Surgery Unknown status NCT01841359 Phase 4 Pramlintide
2 Lactate and Hypoglycemia Unknown status NCT01387477 Phase 4 Lactate;Glucose
3 Use of Diazoxide in Acute Hypoglycaemia Unknown status NCT01488136 Phase 4 Diazoxide;Placebo
4 Glucose Control During Labour in Gestational Diabetes Mellitus With Insulin Treatment: A Randomized Controlled Trial Unknown status NCT02590016 Phase 4 Insulin, Aspart
5 Do Sulphonylureas Preserve Cortical Function During Hypoglycaemia? Unknown status NCT00472875 Phase 4 Glibenclamide
6 Treatment of Low Blood Sugar With Glucagon Among Patients With Type 1 Diabetes Unknown status NCT02232971 Phase 4 Glucagon
7 Outpatient Discharge Therapy With Saxagliptin+MetforminXR vs GlipizideXL for Type 2 Diabetes With Severe Hyperglycemia Unknown status NCT01267448 Phase 4 Glipizide XL;Saxagliptin + Metformin XR;Metformin XR
8 Glucometer and Mobile-phone Based Data Transfer System in Diabetes Unknown status NCT02769377 Phase 4
9 Comparing Long-acting Insulins During Exercise in Type 1 Diabetes Unknown status NCT01440439 Phase 4 Insulin glargine;Insulin detemir
10 Real-Time Continuous Glucose Monitoring in Pre-School Children With Type-1 Diabetes Mellitus Unknown status NCT01016457 Phase 4
11 Intensive Insulin Therapy for Strict Glycemic Control in Neurosurgical Patients: Safety and Efficacy Unknown status NCT00505505 Phase 4 Insulin (Actrapid)
12 Lanreotide Autogel Treatment of Patients With Congenital Hyperinsulinism of Infancy Unknown status NCT01070758 Phase 4 Lanreotide autogel
13 Metformin and Sitagliptin Therapy for Adult Patients With Type 2 Diabetes Admitted to the General Medical Unit Unknown status NCT02250794 Phase 4 metformin and sitagliptin;insulin glargine and insulin lispro;metformin and sitagliptin;insulin glargine and insulin lispro
14 Long-Term Sulfonylurea Response in ABCC8 Neonatal Diabetes (SuResponsSUR) Unknown status NCT02624830 Phase 4 Sulfonylurea
15 Substitution of First Phase Insulin Response in Patient With Type 2 Diabetes. Unknown status NCT00254085 Phase 4 Insulin Aspart
16 Saxagliptin's Effects on Microalbuminuria Improvement in Type 2 Diabetic Patients Unknown status NCT02462369 Phase 4 Saxagliptin;glimepiride
17 Improving Glycaemic Control in Malaysian Patients With Type 2 Diabetes Mellitus With Insulin Pump Therapy Unknown status NCT03112538 Phase 4 Multiple daily injections of insulin
18 Effect of an Artificial Pancreas in Patients Undergoing Pancreatic Resection Unknown status NCT00661648 Phase 4
19 Endobarrier Treatment in Obese Subjects With T2DM Unknown status NCT01718457 Phase 4
20 Exenatide Compared With Insulin Glargine to Change Liver Fat Content in Type 2 Diabetes Unknown status NCT02303730 Phase 4 Exenatide;insulin glargine
21 GLP-1 Analogue Treatment in Uncontrolled Type 1 Diabetic Patients Unknown status NCT01592279 Phase 4 liraglutide;Insulin injections
22 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics Unknown status NCT00845936 Phase 4 Metformin
23 Organization Program of DiabEtes INsulIN ManaGement Unknown status NCT01338376 Phase 4 Scilin®M30
24 Insulin Requirement for Pure-protein Meal in Children With Type 1 Diabetes on Insulin Pumps. Unknown status NCT02685449 Phase 4 Insulin glulisine;Insulin aspart;Insulin lispro
25 A Double-Blind, Randomized, Parallel, Comparative Study to Evaluate the Efficacy and Safety of an Antidiabetic Agent Repaglinide for the Treatment of Type 2 Diabetes Mellitus Patients Unknown status NCT00336310 Phase 4 Repaglinide
26 Compare the Effect of DPP-IV Inhibitor or TZD on Glycemic Variability and Oxidative Stress in Patient With 2 Diabetes Unknown status NCT01339143 Phase 4 Galvus (vildagliptin);pioglitazone
27 Exploratory Study to Compare the Effects of Tenelia® or Januvia® on Glucose Variability in add-on to Metformin (CGMS Study) Unknown status NCT02512523 Phase 4 Teneligliptin;Sitagliptin
28 Comparison of Glycaemic Fluctuation and Oxidative Stress Between Two Short-term Therapies for Type 2 Diabetes Unknown status NCT02526810 Phase 4 insulin lispro;Insulin Glargine
29 Comparison Study of Insulin Glargine and NPH Insulin Unknown status NCT01854723 Phase 4 Switching to NPH insulin;Continuation of insulin glargine
30 Continuous Subcutaneous Insulin Infusion strAtegy Versus Multiple Daily Insulin Injections strAtegy Unknown status NCT01574508 Phase 4 Transient Continuous Subcutaneous Insulin Infusion;Transient Multiple Daily Insulin Injections
31 Insulin NovoRapid Versus Actrapid in Treatment of Type 1 Diabetic Patients During Daily Adjustment of Insulin Dose Unknown status NCT00145353 Phase 4 Insulin NovoRapid versus Actrapid
32 Oral Antidiabetic Agents in Pregnancy Unknown status NCT02091336 Phase 4 Metformin;Glyburide
33 Syringes Replacement for Insulin Application for Pens Device in a Population of Elderly Patients With Type 2 Diabetes: Multifactorial Intervention to Improve Glycemic Control Unknown status NCT02517242 Phase 4
34 Effect on Beta Cell Function and Glycaemic Control After Insulin and Exenatide Sequential Therapy Unknown status NCT02129985 Phase 4 Exenatide;Metformin
35 Clinical Study to Compare Various Dosing and Titration Guidelines of Insulin Delivered Via V-Go ® in Patients With Type 2 Diabetes Initiating Basal Bolus Therapy in Primary Care Offices Unknown status NCT02361489 Phase 4
36 Effect of Anti-diabetic Drugs on Glycemic Variability Unknown status NCT02925559 Phase 4 Dapagliflozin;Gliclazide MR
37 Probiotics in Newly Recognized Type 1 Diabetes Unknown status NCT03032354 Phase 4 Lactobacillus rhamnosus GG and Bifidobacterium lactis BB12
38 Effect of SGLT-2 Inhibitor Dapagliflozin on Glycemic Variability in Patients With Diabetes Mellitus Type 2 Unknown status NCT02719756 Phase 4 Metformin;Dapagliflozin;Metformin up-titration
39 Preventing Recurrent Gestational Diabetes With Metformin Unknown status NCT02394158 Phase 4 Metformin;placebo
40 Human Insulin Analogs: Evaluation of Inflammatory mRNA Expression of Macrophages and Endothelial Function of Short-acting Insulin - HERMES Pilot Study Unknown status NCT01417897 Phase 4 Insulin glulisine;Insulin aspart;Regular human insulin
41 The Therapeutic Effects of Insulin and Berberine on Stress Hyperglycemia Unknown status NCT02806999 Phase 4 Berberine; Insulin;Insulin
42 Study on Lixisenatide and Counterregulation to Hypoglycemia Completed NCT02020629 Phase 4 Lixisenatide
43 Vildagliptin and the Glucagon Response to Hypoglycemia in Insulin-Treated Patients With Type 2 Diabetes Completed NCT01219400 Phase 4 Vildagliptin
44 Vildagliptin and the Glucagon Response to Hypoglycemia in Type 1 Diabetes Completed NCT01147276 Phase 4 Vildagliptin
45 Insulin Analogues and Severe Hypoglycaemia Completed NCT00346996 Phase 4 insulin levemir / aspart;human insulin /insulin isophane
46 Treatment With Sitagliptin for Reactive Hypoglycemia Secondary to Dysinsulinism Completed NCT00847080 Phase 4 Sitagliptin phosphate;Placebo
47 Investigating the Accuracy of the Home Glucose Monitors in Hypoglycemia Completed NCT01013402 Phase 4 Human insulin;Human Insulin
48 Treatment of Hypoglycemia Following Gastric Bypass Surgery Completed NCT02527993 Phase 4 Glucobay (acarbose);Januvia (sitagliptin);Verapamil HEXAL (verapamil);Victoza (liraglutide);Signifor (pasireotide)
49 Prevention of Severe Hypoglycemia in Type 1 Diabetes Completed NCT00360984 Phase 4 insulin glargine
50 Continuous Glucose Monitoring and Preterm Infants Completed NCT02583776 Phase 4

Search NIH Clinical Center for Hypoglycemia

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: hypoglycemia

Sources

Genetic Tests for Hypoglycemia

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Genetic tests related to Hypoglycemia:

# Genetic test Affiliating Genes
1 Hypoglycemia 30
Sources

Anatomical Context for Hypoglycemia

About this section

MalaCards organs/tissues related to Hypoglycemia:

42
Pancreas, Brain, Testes, Liver, Kidney, Heart, Pituitary
Sources

Publications for Hypoglycemia

About this section

Articles related to Hypoglycemia:

(show top 50) (show all 7152)
# Title Authors Year
1
Hyperinsulinaemic hypoglycaemia: A new presentation of 16p11.2 deletion syndrome. ( 30776145 )
2019
2
Consecutive hypoglycemia attacks induced by co-trimoxazole followed by pentamidine in a patient with acquired immunodeficiency syndrome. ( 30170528 )
2019
3
Alcohol Dependence, Hypoglycemia, and Transient Movement Disorders. ( 30620452 )
2019
4
Association of attention deficit hyperactivity disorder with recurrent hypoglycemia in type 1 diabetes mellitus. ( 29938875 )
2019
5
The effects of hypoglycemia and dementia on cardiovascular events, falls and fractures and all-cause mortality in older people - a retrospective cohort study. ( 31069922 )
2019
6
Association of Hypoglycemia With Subsequent Dementia in Older Patients With Type 2 Diabetes Mellitus. ( 30947336 )
2019
7
Relationship between depression, sleep quality, and hypoglycemia among persons with type 2 diabetes. ( 30723689 )
2019
8
A general view of epidemiology of hypoglycemia in type 1 and type 2 diabetes mellitus. ( 31091949 )
2019
9
Hypoglycemia as a symptom of adrenal dysfunction in patients with diabetes mellitus: rare but real situation. ( 31091951 )
2019
10
Ethanol and risk of hypoglycemia in patients with type 1 diabetes mellitus: a brief overview for clinical practice. ( 31091952 )
2019
11
Risk factors and outcomes for neonatal hypoglycaemia and neonatal hyperbilirubinaemia in pregnancies complicated by gestational diabetes mellitus: a single centre retrospective 3-year review. ( 30972790 )
2019
12
Hypoglycemia Abrogates the Vascular Endothelial Protective Effect of Exenatide in Type 2 Diabetes Mellitus. ( 30875066 )
2019
13
Cognitive Frailty in Older People with Type 2 Diabetes Mellitus: the Central Role of Hypoglycaemia and the Need for Prevention. ( 30806826 )
2019
14
The Cost of Hypoglycemia Associated With Type 2 Diabetes Mellitus in Taiwan. ( 30776767 )
2019
15
Effect of Education on Impaired Hypoglycemia Awareness and Glycemic Variablity in Children and Adolescents with Type 1 Diabetes Mellitus ( 30701953 )
2019
16
Short-acting insulin analogues versus regular human insulin on postprandial glucose and hypoglycemia in type 1 diabetes mellitus: a systematic review and meta-analysis. ( 30622653 )
2019
17
Severe and persistent hypoglycemia with lactic acidosis in an elderly lady with type 2 diabetes mellitus and lymphoma∖leukemia: A rare case report. ( 30641783 )
2019
18
Risk of hypoglycemia in hospitalized patients with diabetes mellitus. ( 30600143 )
2019
19
Similar glycaemic control with less nocturnal hypoglycaemia in a 38-week trial comparing the IDegAsp co-formulation with insulin glargine U100 and insulin aspart in basal insulin-treated subjects with type 2 diabetes mellitus. ( 30448451 )
2019
20
Hypoglycaemia is associated with increased risk of fractures in patients with type 2 diabetes mellitus: a cohort study. ( 30400051 )
2019
21
Low doses of dasiglucagon consistently increase plasma glucose levels from hypoglycaemia and euglycaemia in people with type 1 diabetes mellitus. ( 30350477 )
2019
22
High one-year mortality following hospitalization for severe hypoglycemia among patients with diabetes mellitus: findings of a retrospective cohort study at an acute tertiary care hospital in Singapore. ( 30244608 )
2019
23
Efficacy and safety of sitagliptin in elderly patients with type 2 diabetes mellitus: A focus on hypoglycemia. ( 30136435 )
2019
24
Diabetes mellitus and hypoglycemia as a complication of intravenous insulin to treat hyperkalemia in the emergency department. ( 30107966 )
2019
25
Risk Factors of Hypoglycemic Encephalopathy and Prolonged Hypoglycemia in Patients With Severe Hypoglycemia. ( 30834045 )
2019
26
Breastfeeding and skin-to-skin contact as non-pharmacological prevention of neonatal hypoglycemia in infants born to women with gestational diabetes; a Danish quasi-experimental study. ( 30928129 )
2019
27
An intravenous insulin protocol designed for pregnancy reduces neonatal hypoglycaemia following betamethasone administration in women with gestational diabetes. ( 30443983 )
2019
28
Primary Cortisol Deficiency and Growth Hormone Deficiency in a Neonate With Hypoglycemia: Coincidence or Consequence? ( 30963141 )
2019
29
Hypoglycemia and hyperglycemia are risk factors for falls in the hospital population. ( 30929079 )
2019
30
Glucagon-like peptide 1 (GLP-1) drives postprandial hyperinsulinemic hypoglycemia in pregnant women with a history of Roux-en-Y gastric bypass operation. ( 30448278 )
2019
31
Hyperinsulinemic hypoglycemia subtype glucokinase V91L mutant induces necrosis in β-cells via ATP depletion. ( 30623114 )
2019
32
Hyperinsulinemic Hypoglycemia in a Neonate. ( 30692138 )
2019
33
Hyperinsulinemic hypoglycemia in seven patients with de novo NSD1 mutations. ( 30719864 )
2019
34
Letters about Published Papers Letters of comment about recently published papers should be sent by email to: bgoldspiel@verizon.net. ( 30760166 )
2019
35
A novel treatment of hyperinsulinemic hypoglycemia induced by insulin antibodies with alkali administration: a case report. ( 30853027 )
2019
36
Sirolimus: Efficacy and Complications in Children With Hyperinsulinemic Hypoglycemia: A 5-Year Follow-Up Study. ( 30882046 )
2019
37
Tracer Accumulation in Relation to Venous Thrombus on 18F-DOPA PET/CT in a Case of Persistent Hyperinsulinemic Hypoglycemia of Infancy. ( 31057687 )
2019
38
Clinical and Enzymatic Phenotypes in Congenital Hyperinsulinemic Hypoglycemia due to Glucokinase-activating Mutations: a report of two cases and a brief overview of literature. ( 31094068 )
2019
39
Continuous Intragastric Dextrose: A Therapeutic Option for Refractory Hypoglycemia in Congenital Hyperinsulinism. ( 30086540 )
2019
40
Therapies and outcomes of congenital hyperinsulinism-induced hypoglycaemia. ( 30246418 )
2019
41
The effect of hypoglycaemia on neurocognitive outcome in children and adolescents with transient or persistent congenital hyperinsulinism. ( 30246438 )
2019
42
Allopurinol reverses mercaptopurine-induced hypoglycemia in patients with acute lymphoblastic leukemia. ( 30828444 )
2019
43
Hypoglycemia does not affect the progression of preclinical atherosclerosis in subjects with type 2 diabetes. ( 30835778 )
2019
44
A Feasibility Study to Detect Neonatal Hypoglycemia in Infants of Diabetic Mothers Using Real-Time Continuous Glucose Monitoring. ( 30839229 )
2019
45
Impact of CGM on the Management of Hypoglycemia Problems: Overview and Secondary Analysis of the HypoDE Study. ( 30841740 )
2019
46
Accuracy of a composite event definition for hypoglycemia. ( 30843332 )
2019
47
Detecting Hypoglycemia Incidents Reported in Patients' Secure Messages: Using Cost-Sensitive Learning and Oversampling to Reduce Data Imbalance. ( 30855231 )
2019
48
IMPAIRED AWARENESS OF HYPOGLYCEMIA CONTINUES TO BE A RISK FACTOR FOR SEVERE HYPOGLYCEMIA DESPITE THE USE OF CONTINUOUS GLUCOSE MONITORING SYSTEM IN TYPE 1 DIABETES. ( 30865520 )
2019
49
Prognostic impact of visit-to-visit glycemic variability on the risks of major adverse cardiovascular outcomes and hypoglycemia in patients with different glycemic control and type 2 diabetes. ( 30868413 )
2019
50
Hypoglycemia in the elderly: Watch for atypical symptoms. ( 30870543 )
2019
Sources

Variations for Hypoglycemia

About this section

ClinVar genetic disease variations for Hypoglycemia:

6 (show all 13)
# Gene Variation Type Significance SNP ID Assembly Location
1 SCN9A NM_002977.3(SCN9A): c.1964A> G (p.Lys655Arg) single nucleotide variant Conflicting interpretations of pathogenicity rs121908919 GRCh37 Chromosome 2, 167138296: 167138296
2 SCN9A NM_002977.3(SCN9A): c.1964A> G (p.Lys655Arg) single nucleotide variant Conflicting interpretations of pathogenicity rs121908919 GRCh38 Chromosome 2, 166281786: 166281786
3 G6PC NM_000151.3(G6PC): c.247C> T (p.Arg83Cys) single nucleotide variant Pathogenic rs1801175 GRCh37 Chromosome 17, 41055964: 41055964
4 G6PC NM_000151.3(G6PC): c.247C> T (p.Arg83Cys) single nucleotide variant Pathogenic rs1801175 GRCh38 Chromosome 17, 42903947: 42903947
5 ABCC8 NM_000352.4(ABCC8): c.3517G> A (p.Val1173Met) single nucleotide variant Likely pathogenic rs141322087 GRCh37 Chromosome 11, 17426099: 17426099
6 ABCC8 NM_000352.4(ABCC8): c.3517G> A (p.Val1173Met) single nucleotide variant Likely pathogenic rs141322087 GRCh38 Chromosome 11, 17404552: 17404552
7 46;X;t(X;5)(p11.23;q35)dn Translocation Pathogenic
8 KCNJ11 NM_000525.3(KCNJ11): c.185C> G (p.Thr62Arg) single nucleotide variant Likely pathogenic rs1057518775 GRCh38 Chromosome 11, 17387907: 17387907
9 KCNJ11 NM_000525.3(KCNJ11): c.185C> G (p.Thr62Arg) single nucleotide variant Likely pathogenic rs1057518775 GRCh37 Chromosome 11, 17409454: 17409454
10 ABCC8 NM_000352.4(ABCC8): c.1793G> A (p.Arg598Gln) single nucleotide variant Likely pathogenic rs1344172059 GRCh38 Chromosome 11, 17430838: 17430838
11 ABCC8 NM_000352.4(ABCC8): c.1793G> A (p.Arg598Gln) single nucleotide variant Likely pathogenic rs1344172059 GRCh37 Chromosome 11, 17452385: 17452385
12 ABCC8 NM_000352.4(ABCC8): c.1024G> T (p.Gly342Trp) single nucleotide variant Likely pathogenic rs763028380 GRCh37 Chromosome 11, 17474818: 17474818
13 ABCC8 NM_000352.4(ABCC8): c.1024G> T (p.Gly342Trp) single nucleotide variant Likely pathogenic rs763028380 GRCh38 Chromosome 11, 17453271: 17453271
Sources

Expression for Hypoglycemia

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Search GEO for disease gene expression data for Hypoglycemia.
Sources

Pathways for Hypoglycemia

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Pathways related to Hypoglycemia according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Metabolism 67
Show member pathways
 13.83 ABCC8 ACADM ACADVL AGL CPT1A CPT2
2
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 67
Show member pathways
 13.51 AKT2 CPT1A CPT2 GCG INS INSR
3
Aldosterone synthesis and secretion 38
Show member pathways
 12.89 ABCC8 AKT2 GCG GCK INS KCNJ11
4
Regulation of lipid metabolism Insulin signaling-generic cascades 23
Show member pathways
 12.85 AKT2 FBP1 G6PC GCK GYS2 INS
5
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) 67
Show member pathways
 12.84 ACADM ACADVL CPT1A CPT2 HADH SLC25A20
6
Glycosaminoglycan metabolism 67
Show member pathways
 12.8 AGL FBP1 G6PC GCK GYS2
7
Glucose metabolism 67
Show member pathways
 12.59 AGL FBP1 G6PC GCK GYS2
8
Angiopoietin Like Protein 8 Regulatory Pathway 1
Show member pathways
 12.47 AKT2 FBP1 G6PC GYS2 INS INSR
9
Glucose / Energy Metabolism 4
12.47 AKT2 CPT1A FBP1 GCG GLUD1 INS
10
AMP-activated Protein Kinase (AMPK) Signaling 1
Show member pathways
 12.36 AKT2 CPT1A FBP1 G6PC GYS2 INS
11
Integration of energy metabolism 67
Show member pathways
 12.3 ABCC8 GCG INS KCNJ11
12
Carbon metabolism 38
Show member pathways
 12.25 ACADM FBP1 GCK GLUD1
13
AMPK Enzyme Complex Pathway 65
Show member pathways
 12.17 AKT2 CPT1A CPT2 GYS2 INS INSR
14
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.12 ACADM CPT1A G6PC GCK
15
FoxO signaling pathway 38
Show member pathways
 12.02 AKT2 G6PC INS INSR
16
Galactose metabolism 23 38
Show member pathways
 11.96 AGL G6PC GCK GYS2
17
Hepatic ABC Transporters 65
Show member pathways
 11.94 GCK INS INSR
18
DNA Damage Response (only ATM dependent) 1
11.9 AKT2 G6PC INSR
19
Type II diabetes mellitus 1 38
Show member pathways
 11.87 ABCC8 GCK INS INSR KCNJ11
20
Fatty acid metabolism 38
Show member pathways
 11.86 ACADM ACADVL CPT1A CPT2 HADH
21
HIF-1 signaling pathway 38
11.84 AKT2 INS INSR
22
Insulin resistance 38
Show member pathways
 11.84 AKT2 CPT1A G6PC GYS2 INS INSR
23
Regulation of beta-cell development 67
Show member pathways
 11.83 AKT2 GCK INS
24
Amino Acid metabolism 1
11.79 ACADM GLUD1 HADH
25
PPAR signaling pathway 38
11.68 ACADM CPT1A CPT2
26
Adipocytokine signaling pathway 38
11.65 AKT2 CPT1A G6PC
27
Mitochondrial Fatty Acid Beta-Oxidation 67
Show member pathways
 11.62 ACADM ACADVL HADH
28
Regulation of lipolysis in adipocytes 38
11.53 AKT2 INS INSR
29
Glucagon signaling pathway 38
11.51 AKT2 CPT1A FBP1 G6PC GCG GCK
30
Development_Leptin signaling via PI3K-dependent pathway 23
11.48 ABCC8 AKT2 CPT1A GYS2 KCNJ11
31
Insulin Pathway 1
11.41 AKT2 INS INSR
32
Mitochondrial LC-Fatty Acid Beta-Oxidation 1
Show member pathways
 11.36 ACADM ACADVL CPT1A CPT2 HADH SLC25A20
33
Insulin-mediated glucose transport 1
11.21 AKT2 INS INSR
34
PPAR Alpha Pathway 1
11.15 ACADM CPT1A CPT2
35
FOXA2 and FOXA3 transcription factor networks 1
10.92 ABCC8 ACADM ACADVL CPT1A G6PC GCK
36
Import of palmitoyl-CoA into the mitochondrial matrix 67
10.74 CPT1A CPT2 SLC25A20
Sources

GO Terms for Hypoglycemia

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Cellular components related to Hypoglycemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule lumen GO:0034774 9.33 AGL GCG INS
2 mitochondrion GO:0005739 9.32 ABCC8 ACADM ACADVL CPT1A CPT2 GCK
3 inward rectifying potassium channel GO:0008282 8.96 ABCC8 KCNJ11

Biological processes related to Hypoglycemia according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.97 ACADM ACADVL CPT1A CPT2 HADH SLC16A1
2 response to drug GO:0042493 9.93 ABCC8 CPT1A CRH HADH KCNJ11
3 metabolic process GO:0008152 9.86 AGL FBP1 GCK GYS2
4 carbohydrate metabolic process GO:0005975 9.85 AKT2 FBP1 GCK INS INSR
5 fatty acid metabolic process GO:0006631 9.83 ACADM ACADVL CPT1A CPT2 HADH
6 cellular response to insulin stimulus GO:0032869 9.8 AKT2 GCK INSR
7 regulation of lipid metabolic process GO:0019216 9.8 ACADM CPT1A CPT2
8 insulin receptor signaling pathway GO:0008286 9.79 AKT2 INS INSR
9 glucose homeostasis GO:0042593 9.77 G6PC GCK INS INSR SLC16A1
10 glycogen metabolic process GO:0005977 9.7 AGL AKT2 G6PC
11 positive regulation of glucose import GO:0046326 9.69 AKT2 INS INSR
12 positive regulation of glycolytic process GO:0045821 9.65 INS INSR
13 negative regulation of insulin secretion GO:0046676 9.65 ABCC8 HADH KCNJ11
14 glucose metabolic process GO:0006006 9.65 AKT2 CPT1A GCK INS KCNJ11
15 cellular glucose homeostasis GO:0001678 9.64 ABCC8 GCK
16 positive regulation of calcium ion import GO:0090280 9.64 CRH GCG
17 negative regulation of gluconeogenesis GO:0045721 9.63 GCK INS
18 regulation of gluconeogenesis GO:0006111 9.62 ACADM FBP1
19 glycogen biosynthetic process GO:0005978 9.62 ACADM AGL AKT2 GYS2
20 glycogen catabolic process GO:0005980 9.61 AGL G6PC
21 fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 9.6 ACADM ACADVL
22 glucose 6-phosphate metabolic process GO:0051156 9.59 G6PC GCK
23 neuron projection maintenance GO:1990535 9.58 INS INSR
24 positive regulation of fatty acid beta-oxidation GO:0032000 9.58 AKT2 CPT1A
25 carnitine shuttle GO:0006853 9.58 CPT1A CPT2 SLC25A20
26 carnitine metabolic process GO:0009437 9.57 ACADM CPT1A
27 positive regulation of respiratory burst GO:0060267 9.55 INS INSR
28 positive regulation of glycogen biosynthetic process GO:0045725 9.46 AKT2 GCK INS INSR
29 fatty acid beta-oxidation GO:0006635 9.35 ACADM ACADVL CPT1A CPT2 HADH
30 regulation of insulin secretion GO:0050796 9.1 ABCC8 CPT1A GCG GCK KCNJ11 SLC16A1

Molecular functions related to Hypoglycemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.91 ACADM CPT1A FBP1 GCG GLUD1 INS
2 hormone activity GO:0005179 9.58 CRH GCG INS
3 insulin-like growth factor receptor binding GO:0005159 9.37 INS INSR
4 NAD+ binding GO:0070403 9.32 GLUD1 HADH
5 acyl-CoA dehydrogenase activity GO:0003995 9.16 ACADM ACADVL
6 glucose binding GO:0005536 8.96 GCK
7 ATP-activated inward rectifier potassium channel activity GO:0015272 8.65 KCNJ11
8 carnitine O-palmitoyltransferase activity GO:0004095 8.62 CPT1A CPT2
Sources

Sources for Hypoglycemia

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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