MCID: HYP056
MIFTS: 68

Hypoglycemia

Categories: Blood diseases, Endocrine diseases, Metabolic diseases

Aliases & Classifications for Hypoglycemia

MalaCards integrated aliases for Hypoglycemia:

Name: Hypoglycemia 12 75 29 55 6 43 44 15 72
Hypoglycaemia 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:9993
ICD9CM 35 251.2
MeSH 44 D007003
NCIt 50 C3126
SNOMED-CT 68 66694000
ICD10 33 E16.2
UMLS 72 C0020615

Summaries for Hypoglycemia

MedlinePlus : 43 Hypoglycemia means low blood glucose, or blood sugar. Your body needs glucose to have enough energy. After you eat, your blood absorbs glucose. If you eat more sugar than your body needs, your muscles, and liver store the extra. When your blood sugar begins to fall, a hormone tells your liver to release glucose. In most people, this raises blood sugar. If it doesn't, you have hypoglycemia, and your blood sugar can be dangerously low. Signs include Hunger Shakiness Dizziness Confusion Difficulty speaking Feeling anxious or weak In people with diabetes, hypoglycemia is often a side effect of diabetes medicines. Eating or drinking something with carbohydrates can help. If it happens often, your health care provider may need to change your treatment plan. You can also have low blood sugar without having diabetes. Causes include certain medicines or diseases, hormone or enzyme deficiencies, and tumors. Laboratory tests can help find the cause. The kind of treatment depends on why you have low blood sugar. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Hypoglycemia, also known as hypoglycaemia, is related to hyperinsulinemic hypoglycemia, familial, 3 and hyperinsulinemic hypoglycemia, familial, 6, and has symptoms including sugar craving An important gene associated with Hypoglycemia is G6PC (Glucose-6-Phosphatase Catalytic Subunit), and among its related pathways/superpathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs Metformin and lanreotide have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and liver, and related phenotypes are no effect and homeostasis/metabolism

Disease Ontology : 12 A glucose metabolism disease that is characterized by abnormally low levels of blood glucose.

Wikipedia : 75 Hypoglycemia, also known as low blood sugar, is when blood sugar decreases to below normal levels. This... more...

Related Diseases for Hypoglycemia

Diseases related to Hypoglycemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1105)
# Related Disease Score Top Affiliating Genes
1 hyperinsulinemic hypoglycemia, familial, 3 34.7 GCK G6PC ABCC8
2 hyperinsulinemic hypoglycemia, familial, 6 34.7 INS HADH GLUD1
3 hyperinsulinemic hypoglycemia, familial, 7 34.6 SLC16A1 INS GCG
4 hirata disease 33.5 INS GCG ABCC8
5 glycogen storage disease type 0 33.4 GYS2 AGL
6 fasting hypoglycemia 33.2 INSR GYS2 GLUD1 CRH ACADM
7 hyperinsulinemic hypoglycemia 33.2 SLC16A1 KCNJ11 INSR INS HADH GLUD1
8 fructose-1,6-bisphosphatase deficiency 32.7 GCG G6PC FBP1
9 insulinomatosis and diabetes mellitus 32.6 INS ABCC8
10 glycogen storage disease iii 32.5 GCG G6PC AGL
11 epiphyseal dysplasia, multiple, with early-onset diabetes mellitus 32.3 KCNJ11 ABCC8
12 hyperinsulinism 32.0 KCNJ11 INSR INS HADH GLUD1 GCK
13 long-chain 3-hydroxyacyl-coa dehydrogenase deficiency 32.0 HADH ACADVL ACADM
14 carnitine-acylcarnitine translocase deficiency 31.7 SLC25A20 CPT2 CPT1A
15 carnitine palmitoyltransferase ii deficiency, infantile 31.6 SLC25A20 CPT2 CPT1A ACADVL
16 insulinoma 31.6 INS GCK GCG ABCC8
17 3-hydroxyacyl-coa dehydrogenase deficiency 31.6 INS HADH GLUD1 GCK ACADVL ACADM
18 acyl-coa dehydrogenase, very long-chain, deficiency of 31.4 SLC25A20 HADH CPT2 ACADVL
19 carnitine deficiency, systemic primary 31.2 SLC25A20 CPT2 ACADVL
20 gestational diabetes 30.9 KCNJ11 INSR INS GCK
21 insulin-like growth factor i 30.9 INSR INS AKT2
22 hyperglycemia 30.9 KCNJ11 INSR INS GCK GCG G6PC
23 carnitine palmitoyltransferase i deficiency 30.8 SLC25A20 HADH CPT2 CPT1A ACADVL
24 munchausen by proxy 30.7 KCNJ11 GCK ABCC8
25 diabetes mellitus 30.6 KCNJ11 INSR INS GCK GCG AKT2
26 maturity-onset diabetes of the young 30.5 KCNJ11 INS GCK GCG ABCC8
27 glucose intolerance 30.5 INSR INS GCK GCG
28 neonatal diabetes mellitus 30.4 KCNJ11 INS GCK ABCC8
29 monocarboxylate transporter 1 deficiency 30.4 SLC16A1 INS GLUD1
30 monogenic diabetes 30.3 KCNJ11 INS GCK ABCC8
31 diabetes mellitus, permanent neonatal 30.3 KCNJ11 INS GCK ABCC8
32 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 30.2 INSR INS
33 acute insulin response 30.1 KCNJ11 INS GCG ABCC8
34 maturity-onset diabetes of the young, type 2 30.0 INS GCK
35 pancreas disease 29.9 KCNJ11 INS GCG ABCC8
36 atrial standstill 1 29.7 SLC25A20 AGL ACADVL
37 sheehan syndrome 29.7 INS CRH
38 diabetes mellitus, noninsulin-dependent 29.7 KCNJ11 INSR INS GCK GCG G6PC
39 carbohydrate metabolic disorder 29.5 INS G6PC AGL ABCC8
40 glucose metabolism disease 29.2 KCNJ11 INS GCK GCG G6PC ABCC8
41 body mass index quantitative trait locus 11 29.0 INSR INS GCK GCG CRH CPT1A
42 maturity-onset diabetes of the young, type 1 28.9 KCNJ11 INSR INS GCK GCG AKT2
43 hyperinsulinemic hypoglycemia, familial, 2 12.8
44 hyperinsulinemic hypoglycemia, familial, 1 12.8
45 hyperinsulinemic hypoglycemia, familial, 5 12.7
46 hypoglycemia, leucine-induced 12.7
47 hyperinsulinemic hypoglycemia, familial, 4 12.7
48 hypoinsulinemic hypoglycemia with hemihypertrophy 12.6
49 immunodeficiency 59 and hypoglycemia 12.4
50 glycogen storage disease 0, liver 12.1

Comorbidity relations with Hypoglycemia via Phenotypic Disease Network (PDN): (show all 30)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alzheimer Disease
Benign Essential Hypertension Bronchitis
Cerebral Atherosclerosis Decubitus Ulcer
Deficiency Anemia Diabetic Polyneuropathy
Encephalopathy Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Hypoglycemic Coma Hypothyroidism
Intermediate Coronary Syndrome Iron Deficiency Anemia
Kidney Disease Microvascular Complications of Diabetes 1
Microvascular Complications of Diabetes 7 Mitral Valve Disease
Peripheral Vascular Disease Protein-Energy Malnutrition
Respiratory Failure Schizophreniform Disorder
Sinoatrial Node Disease Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Hypoglycemia:



Diseases related to Hypoglycemia

Symptoms & Phenotypes for Hypoglycemia

UMLS symptoms related to Hypoglycemia:


sugar craving

GenomeRNAi Phenotypes related to Hypoglycemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 ABCC8 ACADM ACADVL AGL AKT2 CPT1A

MGI Mouse Phenotypes related to Hypoglycemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 ABCC8 ACADM ACADVL AGL AKT2 CPT1A
2 growth/size/body region MP:0005378 10.11 ACADVL AKT2 CRH G6PC GCK GLUD1
3 endocrine/exocrine gland MP:0005379 10.1 ABCC8 AKT2 CRH GCK GLUD1 HADH
4 cardiovascular system MP:0005385 10.09 ACADM ACADVL CPT1A CPT2 GYS2 INS
5 adipose tissue MP:0005375 10.06 ACADVL AKT2 CRH HADH INS INSR
6 liver/biliary system MP:0005370 10.03 ACADM ACADVL AGL AKT2 CRH G6PC
7 mortality/aging MP:0010768 9.97 ACADM ACADVL AGL AKT2 CPT1A CPT2
8 muscle MP:0005369 9.56 ACADM ACADVL AGL AKT2 GYS2 INS
9 renal/urinary system MP:0005367 9.17 CRH G6PC GCK HADH INS INSR

Drugs & Therapeutics for Hypoglycemia

DrugBank drugs 16 :

# Drug Name Indication DrugBank ID
1 Dextrose, unspecified form Glucose pharmaceutical formulations (oral tablets, injections) are indicated for caloric supply and carbohydrate supplementation in case of nutrient deprivation. It is also used in metabolic disorders such as hypoglycemia. DB09341

Drugs for Hypoglycemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 557)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 4091 14219
2
lanreotide Approved Phase 4 108736-35-2
3
Isosorbide Dinitrate Approved, Investigational Phase 4 87-33-2 6883
4
AT-101 Approved, Investigational Phase 4 90141-22-3, 652-67-5 12597
5
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
6
Racepinephrine Approved Phase 4 329-65-7 838
7
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
8
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
9
Ethanol Approved Phase 4 64-17-5 702
10
Gliclazide Approved Phase 4 21187-98-4 3475
11
Glipizide Approved, Investigational Phase 4 29094-61-9 3478
12
Fosaprepitant Approved Phase 4 172673-20-0 219090
13
Aprepitant Approved, Investigational Phase 4 170729-80-3 151165 6918365
14
Verapamil Approved Phase 4 52-53-9 2520
15
Caffeine Approved Phase 4 58-08-2 2519
16
Simvastatin Approved Phase 4 79902-63-9 54454
17
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
18
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
19
Dextromethorphan Approved Phase 4 125-71-3 5360696 5362449
20
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
21
Chlorzoxazone Approved Phase 4 95-25-0 2733
22
Tolbutamide Approved, Investigational Phase 4 64-77-7 5505
23
Bupropion Approved Phase 4 34841-39-9, 34911-55-2 444
24
Nitric Oxide Approved Phase 4 10102-43-9 145068
25
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
26
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
27
Haloperidol Approved Phase 4 52-86-8 3559
28
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
29
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
30
Linagliptin Approved Phase 4 668270-12-0 10096344
31
Repaglinide Approved, Investigational Phase 4 135062-02-1 65981
32
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
33
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
34
Alogliptin Approved Phase 4 850649-61-5 11450633
35
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
36
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
37
Glucagon Approved Phase 4 16941-32-5
38
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
39
Liraglutide Approved Phase 4 204656-20-2 44147092
40
Empagliflozin Approved Phase 4 864070-44-0
41
Saxagliptin Approved Phase 4 361442-04-8 11243969
42
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
43
Insulin Detemir Approved Phase 4 169148-63-4 5311023
44
Glimepiride Approved Phase 4 93479-97-1 3476
45
tannic acid Approved Phase 4 1401-55-4
46
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
47
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
48
Canagliflozin Approved Phase 4 842133-18-0
49
Testosterone enanthate Approved Phase 4 315-37-7 9416
50
Methyltestosterone Approved Phase 4 58-18-4 6010

Interventional clinical trials:

(show top 50) (show all 1638)
# Name Status NCT ID Phase Drugs
1 Comparison of Two Strategies of Hypoglycemia Correction in ICU Unknown status NCT01387477 Phase 4 Lactate;Glucose
2 Do Sulphonylureas Preserve Cortical Function During Hypoglycaemia? Unknown status NCT00472875 Phase 4 Glibenclamide
3 Use of Diazoxide in Acute Hypoglycaemia Unknown status NCT01488136 Phase 4 Diazoxide;Placebo
4 Randomized, Open Prospective Study of the Effect of SGLT-2 Inhibitor Dapagliflozin on Glycemic Variability in Patients With Diabetes Mellitus Type 2 Unknown status NCT02719756 Phase 4 Metformin;Dapagliflozin;Metformin up-titration
5 The Effect of Saxagliptin on Glucose Fluctuation and Immune Regulation in Patients With Type 1 Diabetes Unknown status NCT02307695 Phase 4 Saxagliptin;Insulin
6 Exenatide BID Compared With Insulin Glargine to Change Liver Fat Content in Non-alcoholic Fatty-liver Disease Patients With Type 2 Diabetes Unknown status NCT02303730 Phase 4 Exenatide;insulin glargine
7 Impact of Insulin Detemir Versus Insulin Glargine on Glycaemic Control and Metabolism During Exercise in Type 1 Diabetes Unknown status NCT01440439 Phase 4 Insulin glargine;Insulin detemir
8 Pramlintide (Symlin) for the Treatment of Hypoglycemia Following Gastric Bypass Surgery Unknown status NCT01841359 Phase 4 Pramlintide
9 Is Insulin NovoRapid Better Than Actrapid for Treating Type 1 Diabetic Patients When Simultaneously, Daily Adjusting the Insulin Dose? Unknown status NCT00145353 Phase 4 Insulin NovoRapid versus Actrapid
10 Real-Time Continuous Glucose Monitoring in Pre-School Children With Type-1 Diabetes Mellitus Unknown status NCT01016457 Phase 4
11 Treatment of Hypoglycemia With Glucagon Among Patients With Type 1 Diabetes Mellitus Unknown status NCT02232971 Phase 4 Glucagon
12 Basal-bolus Insulin Therapy With Insulin Degludec and Insulin Aspart Versus Standard Therapy for the Inpatient Management of Type 2 Diabetes: the IDA2 Study Unknown status NCT03244241 Phase 4 Insulin Degludec 100 UNT/ML [Tresiba]
13 Glucose Control During Labour in Gestational Diabetes Mellitus With Insulin Treatment: Insulin-Glucose-Infusion Versus Observational Approach - Is There a Difference in Neonatal Hypoglycemia Rate? Unknown status NCT02590016 Phase 4 Insulin, Aspart
14 Effects of Intensive Insulin Therapy on Mortality, Morbidity and Long Term Neurologic Outcome in Neurosurgical Intensive Care Patients Unknown status NCT00505505 Phase 4 Insulin (Actrapid)
15 Investigation of a Switch From Insulin Therapy to a Metformin & Saxagliptin Combination in Patients With Type 2 Diabetes Mellitus Unknown status NCT01206647 Phase 4 Metformin and Saxagliptin
16 Optimal Insulin Correction Factor in Post- High Intensity Exercise Hyperglycemia in Adults With Type 1 Diabetes: The FIT Study Unknown status NCT03057470 Phase 4 50% bolus insulin correction;100% bolus insulin correction;150% bolus insulin correction
17 Metformin and Sitagliptin Therapy for Adult Patients With Type 2 Diabetes Admitted to the General Medical Unit Unknown status NCT02250794 Phase 4 metformin and sitagliptin;insulin glargine and insulin lispro;metformin and sitagliptin;insulin glargine and insulin lispro
18 A Pilot Study of Outpatient Discharge Therapy With Saxagliptin + Metformin XR or Sulphonylurea for Recently Diagnosed Type 2 Diabetes Presenting With Severe Hyperglycemia Unknown status NCT01267448 Phase 4 Glipizide XL;Saxagliptin + Metformin XR;Metformin XR
19 Organization Program of DiabEtes INsulIN ManaGement: An Open, Multi-center, Prospective, Randomized, 16-week, Controlled Clinical Study Unknown status NCT01338376 Phase 4 Scilin®M30
20 Explore the Efficacy of Acarbose and Metformin on Blood Glucose Fluctuation When Combined With Premix Insulin in Chinese Type 2 Diabetes by CGMS Unknown status NCT02438397 Phase 4 premix insulin;metformin;Acarbose
21 Treatment With Lanreotide Autogel (Somatostatin Analogue) in Patients With Congenital Hyperinsulinism of Infancy Already Treated With Somatostatin Analog by Pump Unknown status NCT01070758 Phase 4 Lanreotide autogel
22 A Double-Blind, Randomized, Parallel, Comparative Study to Evaluate the Efficacy and Safety of an Antidiabetic Agent Repaglinide for the Treatment of Type 2 Diabetes Mellitus Patients Unknown status NCT00336310 Phase 4 Repaglinide
23 GLP-1 Analogue Treatment in Uncontrolled Type 1 Diabetic Patients Unknown status NCT01592279 Phase 4 liraglutide;Insulin injections
24 The Effect of the GLP-1 Receptor Agonists on Blood Levels of Lipoprotein (a) Unknown status NCT02501850 Phase 4 Liraglutide;metformin
25 The Therapeutic Effects of Combination of Insulin With Berberine on the Patients With Stess Hyperlipemia:a Prospective, Double Blind, Randomized, Placebo-controlled, Single-center Clinical Trial Unknown status NCT02806999 Phase 4 Berberine; Insulin;Insulin
26 Randomized, Long-Term Study About the Effects of Analogue Versus Human Insulin Based Regimens (Insulin Detemir and Aspart Versus NPH- and Regular Human Insulin) on Metabolic Control and Myocardial Function in People With Type 2 Diabetes. Unknown status NCT00747409 Phase 4 insulin aspart and detemir (NovoRapid, Levemir);human regular insulin and NPH insulin (Actrapid, Protaphne)
27 Effect of Exenatide on 24h-UAER in Patients With Diabetic Nephropathy: a 24- Week Study Unknown status NCT02690883 Phase 4 Exenatide;Lispro
28 A Phase IV, Multicenter, Randomized, Active Comparator Controlled Study of the Addition of Pioglitazone Compared With Glimepiride in Subjects With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Metformin and Alogliptin Unknown status NCT02426294 Phase 4 Pioglitazone;Glimepiride
29 Improving Glycaemic Control in Malaysian Patients With Type 2 Diabetes Mellitus With Insulin Pump Therapy Unknown status NCT03112538 Phase 4 Multiple daily injections of insulin
30 An Open-label, Randomized , Phase 4 Study to Compare the Different Efficacies of α-glucosidase Inhibitor and Sulfonylurea on Improvement of Intestinal Microbiome and Serum Incretins in Patients With Type 2 Diabetes Unknown status NCT01758471 Phase 4 Glipizide;Acarbose
31 Healthy Heart Study: Can Insulin Glargine Improve Myocardial Function in Patients With Type 2 Diabetes and Coronary Artery Disease? A Prospective, Randomized, Controlled Clinical Study With Blinded Analysis of Ultrasound Data Unknown status NCT01035528 Phase 4 insulin glargine;metformin
32 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics- Double Blind Placebo Controlled Study Unknown status NCT00845936 Phase 4 Metformin
33 Endobarrier Treatment in Obese Subjects With T2DM Unknown status NCT01718457 Phase 4
34 Absorption and Utilization of a Mixed Meal in Type 1 Diabetes: Creation of a Biological and In Silico Biobank for the Optimization of Artificial Pancreas Systems. A Pilot Study. Unknown status NCT01800734 Phase 4
35 Mechanistic Study of the Systolic Blood Pressure Lowering Effect of Dapagliflozin in Type 2 Diabetes Unknown status NCT02372955 Phase 4 dapagliflozin;glimpiride
36 Effect of Linagliptin on Intestinal Triglyceride-rich-lipoprotein Metabolism in Type 2 Diabetic Patients Unknown status NCT02280174 Phase 4 linagliptin
37 Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus. Unknown status NCT02011620 Phase 4
38 Effect of Anti-diabetic Drugs on Glycemic Variability. A Comparison Between Gliclazide MR (Modified Release) and Dapagliflozin on Glycemic Variability Measured by Continuous Glucose Monitoring (CGM) in Patients With Uncontrolled Type 2 Diabetes Unknown status NCT02925559 Phase 4 Dapagliflozin;Gliclazide MR
39 Effects on Incidence of Cardiovascular Events of the Addition of Pioglitazone as Compared With a Sulphonylurea in Type 2 Diabetic Patients Inadequately Controlled With Metformin. Unknown status NCT00700856 Phase 4 add-on pioglitazone;add-on sulphonylurea
40 Can Hypoglycaemia Awareness Be Restored in Individuals With Type 1 Diabetes and Severe Hypoglycaemia Employing Optimised Subcutaneous Insulin Regime or Continuous Subcutaneous Insulin Infusion Pump Completed NCT00360984 Phase 4 insulin glargine
41 The Effect of Insulin Analogues and Human Insulin on the Incidence of Severe Hypoglycaemia in Hypoglycaemia Prone Type 1 Diabetic Patients Completed NCT00346996 Phase 4 insulin levemir / aspart;human insulin /insulin isophane
42 The Effect of Insulin Degludec on Risk of Symptomatic Nocturnal Hypoglycaemia in Subjects With Type 1 Diabetes and High Risk of Nocturnal Severe Hypoglycaemia Completed NCT02192450 Phase 4 Insulin aspart/glargine;Insulin aspart/degludec
43 The Late Effects of Ethanol Intake on the Glucose Response to Subcutaneous Glucagon in Type 1 Diabetes Completed NCT02881060 Phase 4
44 A Phase IIIb/IV, Multinational, Multicentre, Randomised, Open Study to Establish the Optimal Method for Initiating and Maintaining Lantus® (Insulin Glargine) Therapy Based on a Comparison of Two Treatment Algorithms to Determine Optimal Metabolic Outcomes, Safety, and Satisfaction in Subjects With Type 1 Diabetes Mellitus/ "HALT" Sub-study: Multicentre, Open Clinical Trial to Assess the Effect of Insulin Glargine on Symptomatic Hypoglycaemia, Fear of Hypoglycaemia and Quality of Life in Patients With Type 1 Diabetes Completed NCT00390728 Phase 4 Insulin Glargine
45 A Double-blind, Randomised, Crossover Study to Investigate the Difference in Frequency of Episodes of Hypoglycaemia During Treatment With Biphasic Insulin Aspart 30 Compared to Biphasic Human Insulin 30 in Patients With Well-controlled Type 2 Diabetes Completed NCT01487798 Phase 4 biphasic human insulin 30;biphasic insulin aspart 30
46 National (Brazil), Phase IV, Multicentric, Open Label, Parallel, Comparative Study of the Use of Insulin Glargine + Glulisine or Insulin Regular + NPH Insulin (Isophane Insulin) in Type 2 Diabetes Mellitus Patients With Moderate Renal Failure. Completed NCT01122979 Phase 4 INSULIN GLARGINE;NPH insulin (insulin isophane);INSULIN GLULISINE;Regular insulin
47 Glucagon Efficiency After High and Low Carbohydrate Diet Completed NCT02578498 Phase 4
48 Efficacy of a Continuous GLP-1 Infusion in Comparison to a Structured Insulin Infusion Protocol to Reach Normoglycemia in Non-Fasted Type 2 Diabetic Patients Completed NCT00859079 Phase 4 GLP-1;Human regular insulin intravenously
49 Randomized, Double-blind, Placebo-controlled Trial on the Effectiveness and Safety of Dapagliflozin for Blood Glucose Control During Glucocorticoid Treatment for Acute Exacerbation COPD Completed NCT02253121 Phase 4 Dapagliflozin;Sliding scale insulin
50 Bedtime Insulin Glargine or Bedtime Neutral Protamine Lispro Combined With Sulfonylurea and Metformin in Type 2 Diabetes. A Randomized, Controlled Trial Completed NCT00641407 Phase 4 NPL insulin;Insulin glargine

Search NIH Clinical Center for Hypoglycemia

Inferred drug relations via UMLS 72 / NDF-RT 51 :


DEXTROSE 100% PWDR
Dextrose, unspecified form
Diazoxide
Glucagon
Glucose
GLUCOSE LIQUID

Cochrane evidence based reviews: hypoglycemia

Genetic Tests for Hypoglycemia

Genetic tests related to Hypoglycemia:

# Genetic test Affiliating Genes
1 Hypoglycemia 29

Anatomical Context for Hypoglycemia

MalaCards organs/tissues related to Hypoglycemia:

41
Brain, Testes, Liver, Pancreas, Pituitary, Kidney, Heart

Publications for Hypoglycemia

Articles related to Hypoglycemia:

(show top 50) (show all 37483)
# Title Authors PMID Year
1
Different patterns of electroencephalography during hypoglycemia in type 1 diabetes mellitus: A case report. 38 17
31335712 2019
2
Magnetic resonance imaging changes in a 69-year old man with hypoglycemia induced brain injury: case report and literature review. 38 17
31223419 2019
3
Hyperglycemia is associated with poor in-hospital outcome in elderly patients with acute ischemic stroke. 17
31374068 2019
4
IGF2 over-expression in solitary fibrous tumours is independent of anatomical location and is related to loss of imprinting. 9 38
20527023 2010
5
[A new therapeutic possibility for type 2 diabetes: DPP-4 inhibitors (sitagliptin)]. 9 38
20519186 2010
6
Prolonged survival and improved glycemia in BioBreeding diabetic rats after early sustained exposure to glucagon-like peptide 1. 9 38
20527046 2010
7
Glucose transporter type 1 deficiency: ketogenic diet in three patients with atypical phenotype. 9 38
19515520 2010
8
Type 2 diabetes comorbidities and treatment challenges: rationale for DPP-4 inhibitors. 9 38
20463416 2010
9
Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations. 9 38
20164212 2010
10
Prevention of nocturnal hypoglycemia using predictive alarm algorithms and insulin pump suspension. 9 38
20200307 2010
11
Brain glucosamine boosts protective glucoprivic feeding. 9 38
20179264 2010
12
Improved glycaemic control with minimal hypoglycaemia and no weight change with the once-daily human glucagon-like peptide-1 analogue liraglutide as add-on to sulphonylurea in Japanese patients with type 2 diabetes. 9 38
20380655 2010
13
Transient salt wasting in POMC-deficiency due to infection induced stress. 9 38
19998238 2010
14
A case of a giant phyllodes tumor of the breast with hypoglycemia caused by high-molecular-weight insulin-like growth factor II. 9 38
19259766 2010
15
Effects of incretin hormones on beta-cell mass and function, body weight, and hepatic and myocardial function. 9 38
20206728 2010
16
Solitary fibrous tumor of soft tissue: a case report and immunohistochemical study. 9 38
20340008 2010
17
Type B insulin resistance syndrome with systemic lupus erythematosus. 9 38
20129024 2010
18
Hypoglycemia due to ectopic secretion of insulin-like growth factor-I in a patient with an isolated sarcoidosis of the spleen. 9 38
20081321 2010
19
A novel mutation in the glycogen synthase 2 gene in a child with glycogen storage disease type 0. 9 38
20051115 2010
20
Reaching HbA1c goals with saxagliptin in combination with other oral antidiabetic drugs. 9 38
20107298 2010
21
[Late onset 3-HMG-CoA lyase deficiency: a rare but treatable disorder]. 9 38
19932602 2010
22
Therapeutic options that provide glycemic control and weight loss for patients with type 2 diabetes. 9 38
20107301 2010
23
In vivo phosphoenolpyruvate carboxykinase promoter mapping identifies disrupted hormonal synergism as a target of inflammation during sepsis in mice. 9 38
19821526 2009
24
Novel FBP1 gene mutations in Arab patients with fructose-1,6-bisphosphatase deficiency. 9 38
19259699 2009
25
Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia. 9 38
19790256 2009
26
Differential effects of insulin detemir and neutral protamine Hagedorn (NPH) insulin on hepatic glucose production and peripheral glucose uptake during hypoglycaemia in type 1 diabetes. 9 38
19707744 2009
27
Hyperinsulinaemic hypoglycaemia associated with a heterozygous missense mutation of R1174W in the insulin receptor (IR) gene. 9 38
19170714 2009
28
Treatment of type 1 diabetic patients with glucagon-like peptide-1 (GLP-1) and GLP-1R agonists. 9 38
19925391 2009
29
DPP-4 inhibitors in clinical practice. 9 38
19940419 2009
30
New therapies for diabesity. 9 38
19793506 2009
31
Malignant solitary fibrous tumor: report of 3 cases with unusual features. 9 38
19349855 2009
32
Treatment of dwarfism with recombinant human insulin-like growth factor-1. 9 38
19946434 2009
33
No increased risk of hypoglycaemic episodes during 48 h of subcutaneous glucagon-like-peptide-1 administration in fasting healthy subjects. 9 38
19094067 2009
34
Liraglutide: a once-daily incretin mimetic for the treatment of type 2 diabetes mellitus. 9 38
19638470 2009
35
Defining the importance of daily glycemic control and implications for type 2 diabetes management. 9 38
19820277 2009
36
Selecting among ADA/EASD tier 1 and tier 2 treatment options. 9 38
19744422 2009
37
Differential chemistry (structure), mechanism of action, and pharmacology of GLP-1 receptor agonists and DPP-4 inhibitors. 9 38
19801361 2009
38
Hypoglycemia with intensive insulin therapy in critically ill patients: predisposing factors and association with mortality. 9 38
19623047 2009
39
Beta-human chorionic gonadotropin production associated with phyllodes tumor of the breast: an unusual paraneoplastic phenomenon. 9 38
19624411 2009
40
Treatment of type 2 diabetes with glucagon-like peptide-1 receptor agonists. 9 38
19624785 2009
41
Short-term effects of the long-acting insulin analog detemir and human insulin on plasma levels of insulin-like growth factor-I and its binding proteins in humans. 9 38
19470629 2009
42
[Diagnosis of glycogen storage disease type IIIA by detecting glycogen debranching enzyme activity, glycogen content and structure in muscle]. 9 38
19951495 2009
43
Hemangiopericytoma-associated hypoglycemia improved by glucocorticoid therapy: a case report. 9 38
19387873 2009
44
Expression of insulin-like growth factor 2 in mesenchymal neoplasms. 9 38
19407853 2009
45
Factors determining inadequate hypoglycaemia during insulin tolerance testing (ITT) after pituitary surgery. 9 38
19178524 2009
46
Lys169 of human glucokinase is a determinant for glucose phosphorylation: implication for the atomic mechanism of glucokinase catalysis. 9 38
19617908 2009
47
3-Hydroxyacyl-coenzyme A dehydrogenase deficiency and hyperinsulinemic hypoglycemia: characterization of a novel mutation and severe dietary protein sensitivity. 9 38
19417036 2009
48
Two novel POLG mutations causing hepatic mitochondrial DNA depletion with recurrent hypoketotic hypoglycaemia and fatal liver dysfunction. 9 38
19195941 2009
49
Delay in blood glucose monitoring during an insulin infusion protocol is associated with increased risk of hypoglycemia in intensive care units. 9 38
19670374 2009
50
[A case of retroperitoneal solitary fibrous tumor associated with hypoglycemia]. 9 38
19673425 2009

Variations for Hypoglycemia

ClinVar genetic disease variations for Hypoglycemia:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 G6PC NM_000151.4(G6PC): c.247C> T (p.Arg83Cys) single nucleotide variant Pathogenic rs1801175 17:41055964-41055964 17:42903947-42903947
2 46;X;t(X;5)(p11.23;q35)dn Translocation Pathogenic
3 ABCC8 NM_000352.5(ABCC8): c.3517G> A (p.Val1173Met) single nucleotide variant Likely pathogenic rs141322087 11:17426099-17426099 11:17404552-17404552
4 KCNJ11 NM_000525.3(KCNJ11): c.185C> G (p.Thr62Arg) single nucleotide variant Likely pathogenic rs1057518775 11:17409454-17409454 11:17387907-17387907
5 ABCC8 NM_000352.5(ABCC8): c.1793G> A (p.Arg598Gln) single nucleotide variant Likely pathogenic rs1344172059 11:17452385-17452385 11:17430838-17430838
6 ABCC8 NM_000352.5(ABCC8): c.1024G> T (p.Gly342Trp) single nucleotide variant Likely pathogenic rs763028380 11:17474818-17474818 11:17453271-17453271
7 SCN9A NM_002977.3(SCN9A): c.1964A> G (p.Lys655Arg) single nucleotide variant Conflicting interpretations of pathogenicity rs121908919 2:167138296-167138296 2:166281786-166281786

Expression for Hypoglycemia

Search GEO for disease gene expression data for Hypoglycemia.

Pathways for Hypoglycemia

Pathways related to Hypoglycemia according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 SLC25A20 SLC16A1 KCNJ11 INS HADH GYS2
2
Show member pathways
13.51 SLC25A20 SLC16A1 INSR INS GCG CPT2
3
Show member pathways
12.84 INSR INS GYS2 GCK G6PC FBP1
4
Show member pathways
12.83 SLC25A20 HADH CPT2 CPT1A ACADVL ACADM
5
Show member pathways
12.8 GYS2 GCK G6PC FBP1 AGL
6
Show member pathways
12.79 KCNJ11 INS GCK GCG AKT2 ABCC8
7
Show member pathways
12.58 GYS2 GCK G6PC FBP1 AGL
8 12.47 INSR INS GLUD1 GCG FBP1 CPT1A
9
Show member pathways
12.45 INSR INS GYS2 G6PC FBP1 AKT2
10
Show member pathways
12.36 INSR INS GYS2 G6PC FBP1 CPT1A
11
Show member pathways
12.3 KCNJ11 INS GCG ABCC8
12
Show member pathways
12.25 GLUD1 GCK FBP1 ACADM
13
Show member pathways
12.17 INSR INS GYS2 CPT2 CPT1A AKT2
14 12.11 GCK G6PC CPT1A ACADM
15
Show member pathways
12.01 INSR INS G6PC AKT2
16
Show member pathways
11.95 GYS2 GCK G6PC AGL
17
Show member pathways
11.94 INSR INS GCK
18 11.91 INSR G6PC AKT2
19 11.87 INSR INS AKT2
20
Show member pathways
11.86 KCNJ11 INSR INS GCK ABCC8
21
Show member pathways