MCID: HYP026
MIFTS: 40

Hypoglycemic Coma

Categories: Endocrine diseases, Neuronal diseases

Aliases & Classifications for Hypoglycemic Coma

MalaCards integrated aliases for Hypoglycemic Coma:

Name: Hypoglycemic Coma 12 29 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1607
ICD10 33 E15
ICD9CM 35 251.0
SNOMED-CT 68 71898001
UMLS 73 C0020617

Summaries for Hypoglycemic Coma

Disease Ontology : 12 A brain disease that is characterized by coma or unconsciousness, develops from a prolonged insufficient supply of glucose to the brain, has symptom decreased cognition, has symptom aberrant behavior, has symptom seizure, and has symptom coma.

MalaCards based summary : Hypoglycemic Coma is related to hemangiopericytoma, malignant and diabetes mellitus, noninsulin-dependent, and has symptoms including coma, seizure and decreased cognition. An important gene associated with Hypoglycemic Coma is INS (Insulin), and among its related pathways/superpathways are PI3K-Akt signaling pathway and MAPK signaling pathway. The drugs Tacrolimus and Exenatide have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and liver, and related phenotypes are muscle and reproductive system

Related Diseases for Hypoglycemic Coma

Diseases related to Hypoglycemic Coma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 hemangiopericytoma, malignant 30.4 HBA1 IGF2
2 diabetes mellitus, noninsulin-dependent 29.4 HBA1 IGF2 INS
3 acyl-coa dehydrogenase, medium-chain, deficiency of 11.2
4 anorexia nervosa 10.3
5 hypoglycemia 10.2
6 severe nonproliferative diabetic retinopathy 10.1 INS VEGFA
7 hepatocellular carcinoma 10.1
8 ocular motor apraxia 10.1
9 hepatitis 10.1
10 pediatric angiosarcoma 10.1 HBA1 VEGFA
11 glomeruloid hemangioma 10.1 HBA1 VEGFA
12 skin hemangioma 10.1 HBA1 VEGFA
13 capillary hemangioma 10.1 HBA1 VEGFA
14 drug-induced lupus erythematosus 10.1 HBA1 VEGFA
15 angiomatous meningioma 10.1 HBA1 VEGFA
16 type 1 diabetes mellitus 2 10.1 IGF2 INS
17 lymphangioma 10.1 HBA1 VEGFA
18 carpal tunnel syndrome 10.1 INS VEGFA
19 insulinomatosis and diabetes mellitus 10.1 IGF2 INS
20 lymphangiosarcoma 10.1 HBA1 VEGFA
21 vascular cancer 10.1 HBA1 VEGFA
22 fetal macrosomia 10.1 IGF2 INS
23 connective tissue cancer 10.1 HBA1 VEGFA
24 adult syndrome 10.1 IGF2 INS
25 microvascular complications of diabetes 5 10.1 INS VEGFA
26 islet cell tumor 10.1 IGF2 INS
27 gonadal disease 10.1 INS VEGFA
28 arteries, anomalies of 10.1 INS VEGFA
29 autosomal genetic disease 10.0 INS VEGFA
30 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 10.0 HBA1 HBA2
31 autonomic nervous system disease 10.0 HBA2 INS
32 alpha-thalassemia 10.0 HBA1 HBA2
33 hyperinsulinemic hypoglycemia 10.0 IGF2 INS
34 thalassemia 10.0 HBA1 HBA2
35 urinary system disease 10.0 INS VEGFA
36 methemoglobinemia, beta-globin type 10.0 HBA1 HBA2
37 pancreas disease 10.0 IGF2 INS
38 diabetes mellitus, insulin-dependent, 24 10.0 HBA1 HBA2
39 hydrops fetalis 10.0 HBA1 HBA2
40 hydrops fetalis, nonimmune 10.0 HBA1 HBA2
41 glutathione peroxidase deficiency 10.0 HBA1 HBA2
42 type 1 diabetes mellitus 5 10.0 HBA2 INS
43 immune hydrops fetalis 10.0 HBA1 HBA2
44 heinz body anemias 10.0 HBA1 HBA2
45 erythrocytosis, familial, 7 10.0 HBA1 HBA2
46 immature cataract 10.0 HBA1 HBA2
47 alpha thalassemia-intellectual disability syndrome type 1 10.0 HBA1 HBA2
48 hemoglobin h disease 10.0 HBA1 HBA2
49 hemoglobinopathy 10.0 HBA1 HBA2
50 diabetic polyneuropathy 10.0 NTF3 VEGFA

Comorbidity relations with Hypoglycemic Coma via Phenotypic Disease Network (PDN): (show all 23)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Bronchitis
Chronic Kidney Failure Chronic Myocardial Ischemia
Decubitus Ulcer Deficiency Anemia
Diabetic Polyneuropathy Familial Atrial Fibrillation
Heart Disease Hypertension, Essential
Hypoglycemia Hypothyroidism
Iron Deficiency Anemia Ischemic Heart Disease
Kidney Disease Microvascular Complications of Diabetes 1
Peripheral Vascular Disease Protein-Energy Malnutrition
Respiratory Failure Schizophreniform Disorder
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Hypoglycemic Coma:



Diseases related to Hypoglycemic Coma

Symptoms & Phenotypes for Hypoglycemic Coma

Symptoms:

12
  • coma
  • seizure
  • decreased cognition
  • aberrant behavior

MGI Mouse Phenotypes related to Hypoglycemic Coma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.26 IGF2 INS NTF3 VEGFA
2 reproductive system MP:0005389 9.02 HBA2 IGF2 INS NTF3 VEGFA

Drugs & Therapeutics for Hypoglycemic Coma

Drugs for Hypoglycemic Coma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 1, Phase 2 104987-11-3 445643 439492
2
Exenatide Approved, Investigational Phase 1, Phase 2 141758-74-9 15991534
3
Etanercept Approved, Investigational Phase 1, Phase 2 185243-69-0
4
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 46835353 6436030 5284616
5 Hormones Phase 1, Phase 2
6 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
7 Hypoglycemic Agents Phase 1, Phase 2
8 Analgesics, Non-Narcotic Phase 1, Phase 2
9 Analgesics Phase 1, Phase 2
10 Incretins Phase 1, Phase 2
11 Gastrointestinal Agents Phase 1, Phase 2
12 Immunosuppressive Agents Phase 1, Phase 2
13 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
14 Peripheral Nervous System Agents Phase 1, Phase 2
15 Hormone Antagonists Phase 1, Phase 2
16 Immunologic Factors Phase 1, Phase 2
17 Anti-Inflammatory Agents Phase 1, Phase 2
18 Antirheumatic Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Islet Cell Transplantation in Patients With Type I Diabetes With Previous Kidney Transplantation Completed NCT00315588 Phase 2 Islet Transplantation
2 Islet Transplantation in Type 1 Diabetic Patients Using the Edmonton Protocol of Steroid Free Immunosuppression Completed NCT00566813 Phase 1, Phase 2 Islet Cell Transplant;Islet Cell Transplant plus
3 Islet Cell Transplantation Alone in Patients With Type 1 Diabetes Mellitus: Steroid-Free Immunosuppression Active, not recruiting NCT00306098 Phase 2 islets

Search NIH Clinical Center for Hypoglycemic Coma

Genetic Tests for Hypoglycemic Coma

Genetic tests related to Hypoglycemic Coma:

# Genetic test Affiliating Genes
1 Hypoglycemic Coma 29

Anatomical Context for Hypoglycemic Coma

MalaCards organs/tissues related to Hypoglycemic Coma:

41
Brain, Kidney, Liver, Heart, Eye, Skin, Pancreas

Publications for Hypoglycemic Coma

Articles related to Hypoglycemic Coma:

(show top 50) (show all 113)
# Title Authors Year
1
Risk Factors for Hypoglycemic Coma: A Study of 33 Patients on Insulin Therapy Who Were Transported to the Hospital by Ambulance. ( 29780121 )
2018
2
Hypoglycemic Coma in a Hemodialysis Patient Receiving Blood Glucose-Lowering Therapy With the Single Agent Teneligliptin. ( 29581705 )
2018
3
Cognitive, neurophysiologic and metabolic sequelae of previous hypoglycemic coma revealed by hyperinsulinemic-hypoglycemic clamp in type 1 diabetic patients. ( 28589447 )
2017
4
Recurrent moderate hypoglycemia exacerbates oxidative damage and neuronal death leading to cognitive dysfunction after the hypoglycemic coma. ( 29047291 )
2017
5
Analysis of Risk Factors for Hypoglycemic Coma in 194 Patients with Type 2 Diabetes. ( 29180613 )
2017
6
Hypoglycemic Coma Induced by the Use of Succinic Acid Cibenzoline in Frail Late-stage Elderly Subjects. ( 28626178 )
2017
7
Smartwatch's Application Algorithm to Prevent Sudden Death and Brain Damage in Hypoglycemic Coma. ( 26659660 )
2015
8
Reversible corona radiata diffusion restriction in hypoglycemic coma. ( 25553230 )
2015
9
Roving eye movements in a patient with hypoglycemic coma. ( 25984318 )
2015
10
Recurrent Hypoglycemic Coma as the Initial and Single Clinical Manifestation of Advanced Hepatocellular Carcinoma. ( 25407746 )
2014
11
Regional Assessment of Severe Hypoglycemic Coma Events in Finland. ( 27200578 )
2014
12
Hypoglycemic coma due to insulin autoimmune syndrome induced by methimazole: A rare case report. ( 25289063 )
2014
13
Evaluation of the incidence and risk of hypoglycemic coma associated with selection of basal insulin in the treatment of diabetes: a Finnish register linkage study. ( 24150837 )
2013
14
A case of hypoglycemic coma with good outcome despite sustained unconsciousness and widespread leukoencephalopathy. ( 24097322 )
2013
15
Decreased vascular endothelial growth factor response to acute hypoglycemia in type 2 diabetic patients with hypoglycemic coma. ( 22209065 )
2012
16
Silent myocardial infarction during hypoglycemic coma. ( 22276266 )
2012
17
Effects of d-3-hydroxybutyrate treatment on hypoglycemic coma in rat pups. ( 21056562 )
2011
18
Bilateral posterior shoulder dislocation with defect secondary to hypoglycemic coma. ( 21246228 )
2011
19
Protective effects of d-3-hydroxybutyrate and propionate during hypoglycemic coma: clinical and biochemical insights from infant rats. ( 21439874 )
2011
20
Catecholamine-resistant shock and hypoglycemic coma after cardiotomy in a patient with unexpected isolated ACTH deficiency. ( 21400210 )
2011
21
Elderly case of prolonged hypoglycemic coma presenting with reversible magnetic resonance imaging changes. ( 20887629 )
2010
22
Hypoglycemic coma in a patient with anorexia nervosa coincident with acute exacerbation of liver injury induced by oral intake of nutrients. ( 20686290 )
2010
23
The influence of hypoglycemia on cerebral blood flow in cases of hypoglycemic coma. ( 19305083 )
2009
24
[Multiple endocrine neoplasia type 1 presenting as hypoglycemic coma: a report of four cases and review of literatures]. ( 19484970 )
2009
25
Another dangerous combination for hypoglycemic coma: concurrent use of sibutramine and lorazepam. ( 18202087 )
2008
26
Truncation of the krebs cycle during hypoglycemic coma. ( 18673151 )
2008
27
Teaching NeuroImage: hippocampal involvement in a patient with hypoglycemic coma. ( 19001244 )
2008
28
Extensive white matter injury in hypoglycemic coma. ( 17389314 )
2007
29
The evolution of a pleural nodule into a giant fibrous tumor associated with hypoglycemic coma. ( 17317199 )
2007
30
Hypoglycemic coma secondary to big insulin-like growth factor II secretion by a giant phyllodes tumor of the breast. ( 17319862 )
2007
31
Bilateral basal ganglia lesions after hypoglycemic coma in a 6-year-old child. ( 17621490 )
2007
32
Central pontine myelinolysis associated with a hypoglycemic coma in anorexia nervosa. ( 16168799 )
2005
33
Severe hypoglycemic coma due to insulin autoimmune syndrome. ( 15759820 )
2005
34
[Hypoglycemic coma revealing a solitary fibrous tumor of the pleura]. ( 16292188 )
2005
35
Unexpected recovery from prolonged hypoglycemic coma: a protective role of metformin? ( 15678315 )
2005
36
Malignant solitary fibrous tumor of the thigh accompanied by hypoglycemic coma. A case report. ( 16080476 )
2005
37
Magnetic resonance imaging and diffusion-weighted imaging changes after hypoglycemic coma. ( 15746233 )
2005
38
Hypoglycemic coma in a diabetic patient on peritoneal dialysis due to interference of icodextrin metabolites with capillary blood glucose measurements. ( 15333503 )
2004
39
Hypoglycemic coma in a pregnant woman in association with hepatitis B virus carrier state and hepatocellular carcinoma. ( 14745290 )
2004
40
Reversible hyperintensity lesion on diffusion-weighted MRI in hypoglycemic coma. ( 15277649 )
2004
41
Solitary fibrous tumor of the liver with presenting symptoms of hypoglycemic coma. ( 15098777 )
2004
42
Sulfonylurea-induced prolonged hypoglycemic coma: experience with dexamethasone. ( 12974447 )
2003
43
Olanzapine and hypoglycemic coma in a frail elderly woman. A case report. ( 12971357 )
2003
44
Reversible hypoglycemic coma despite bilateral absence of the median nerve N20 evoked potential. ( 12771284 )
2003
45
Bispectral index monitoring during hypoglycemic coma. ( 12088817 )
2002
46
Diffusion-weighted MR in hypoglycemic coma. ( 11552039 )
2001
47
Protein ubiquitination in rat brain following hypoglycemic coma. ( 11165431 )
2001
48
MK801 decreases glutamate release and oxidative metabolism during hypoglycemic coma in piglets. ( 11412899 )
2001
49
Response to training in blood glucose awareness is related to absence of previous hypoglycemic coma. ( 10937524 )
2000
50
Is neuronal injury caused by hypoglycemic coma of the necrotic or apoptotic type? ( 10905628 )
2000

Variations for Hypoglycemic Coma

Expression for Hypoglycemic Coma

Search GEO for disease gene expression data for Hypoglycemic Coma.

Pathways for Hypoglycemic Coma

GO Terms for Hypoglycemic Coma

Cellular components related to Hypoglycemic Coma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 HBA1 HBA2 IGF2 INS NTF3 VEGFA
2 platelet alpha granule lumen GO:0031093 9.4 IGF2 VEGFA
3 cytosolic small ribosomal subunit GO:0022627 9.37 HBA1 HBA2
4 endocytic vesicle lumen GO:0071682 9.32 HBA1 HBA2
5 hemoglobin complex GO:0005833 9.26 HBA1 HBA2
6 haptoglobin-hemoglobin complex GO:0031838 9.16 HBA1 HBA2
7 extracellular space GO:0005615 9.1 HBA1 HBA2 IGF2 INS NTF3 VEGFA

Biological processes related to Hypoglycemic Coma according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.65 INS NTF3 VEGFA
2 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.62 NTF3 VEGFA
3 cellular oxidant detoxification GO:0098869 9.61 HBA1 HBA2
4 insulin receptor signaling pathway GO:0008286 9.61 IGF2 INS
5 protein heterooligomerization GO:0051291 9.6 HBA1 HBA2
6 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.59 INS NTF3
7 glucose metabolic process GO:0006006 9.58 IGF2 INS
8 response to hydrogen peroxide GO:0042542 9.58 HBA1 HBA2
9 positive regulation of cell death GO:0010942 9.57 HBA1 HBA2
10 positive chemotaxis GO:0050918 9.56 NTF3 VEGFA
11 positive regulation of cell division GO:0051781 9.55 IGF2 VEGFA
12 bicarbonate transport GO:0015701 9.54 HBA1 HBA2
13 activation of protein kinase B activity GO:0032148 9.52 INS NTF3
14 hydrogen peroxide catabolic process GO:0042744 9.51 HBA1 HBA2
15 positive regulation of mitotic nuclear division GO:0045840 9.49 IGF2 INS
16 positive regulation of protein autophosphorylation GO:0031954 9.46 INS VEGFA
17 positive regulation of cell proliferation GO:0008284 9.46 IGF2 INS NTF3 VEGFA
18 positive regulation of receptor internalization GO:0002092 9.43 NTF3 VEGFA
19 positive regulation of glycogen biosynthetic process GO:0045725 9.4 IGF2 INS
20 positive regulation of insulin receptor signaling pathway GO:0046628 9.37 IGF2 INS
21 oxygen transport GO:0015671 9.32 HBA1 HBA2
22 induction of positive chemotaxis GO:0050930 9.26 NTF3 VEGFA
23 regulation of signaling receptor activity GO:0010469 9.26 IGF2 INS NTF3 VEGFA
24 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 8.8 IGF2 NTF3 VEGFA

Molecular functions related to Hypoglycemic Coma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 9.48 NTF3 VEGFA
2 oxygen binding GO:0019825 9.46 HBA1 HBA2
3 peroxidase activity GO:0004601 9.43 HBA1 HBA2
4 growth factor activity GO:0008083 9.43 IGF2 NTF3 VEGFA
5 receptor ligand activity GO:0048018 9.4 IGF2 VEGFA
6 insulin receptor binding GO:0005158 9.37 IGF2 INS
7 insulin-like growth factor receptor binding GO:0005159 9.32 IGF2 INS
8 oxygen carrier activity GO:0005344 9.16 HBA1 HBA2
9 organic acid binding GO:0043177 8.96 HBA1 HBA2
10 haptoglobin binding GO:0031720 8.62 HBA1 HBA2

Sources for Hypoglycemic Coma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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