Aliases & Classifications for Hypoglycemic Coma

MalaCards integrated aliases for Hypoglycemic Coma:

Name: Hypoglycemic Coma 12 54 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1607
ICD9CM 34 251.0
SNOMED-CT 67 71898001
ICD10 32 E15
UMLS 71 C0020617

Summaries for Hypoglycemic Coma

Disease Ontology : 12 A brain disease that is characterized by coma or unconsciousness, develops from a prolonged insufficient supply of glucose to the brain, has symptom decreased cognition, has symptom aberrant behavior, has symptom seizure, and has symptom coma.

MalaCards based summary : Hypoglycemic Coma is related to hirata disease and insulinoma, and has symptoms including coma, seizure and decreased cognition. An important gene associated with Hypoglycemic Coma is INS (Insulin), and among its related pathways/superpathways are Integration of energy metabolism and Ras signaling pathway. Affiliated tissues include brain, pancreas and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Hypoglycemic Coma

Diseases related to Hypoglycemic Coma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 hirata disease 30.8 INS GCG
2 insulinoma 30.6 INS IGF2 GCG
3 potter's syndrome 30.4 INS IGF2
4 hypoglycemia 30.4 VEGFA INS IGF2 GCG DPP4
5 islet cell tumor 30.1 INS IGF2 GCG
6 hyperinsulinemic hypoglycemia 30.1 INS IGF2 GCG
7 gestational diabetes 30.0 INS IGF2 GCG
8 diabetes mellitus, ketosis-prone 29.8 INS GCG DPP4
9 hyperglycemia 29.5 INS GCG DPP4
10 hyperinsulinism 29.4 INS IGF2 GCG DPP4
11 diabetes mellitus 28.8 VEGFA INS IGF2 HBA1 GCG DPP4
12 diabetes mellitus, insulin-dependent 28.2 VEGFA INS IGF2 HBA2 HBA1 GCG
13 acyl-coa dehydrogenase, medium-chain, deficiency of 11.4
14 ocular motor apraxia 11.2
15 retroperitoneal hemangiopericytoma 10.4 VEGFA INS
16 retinal microaneurysm 10.4 VEGFA INS
17 severe nonproliferative diabetic retinopathy 10.4 VEGFA INS
18 erythematosquamous dermatosis 10.3 INS GCG
19 background diabetic retinopathy 10.3 VEGFA INS
20 type 1 diabetes mellitus 2 10.3 INS IGF2
21 fetal macrosomia 10.3 INS IGF2
22 decubitus ulcer 10.3 VEGFA INS
23 postgastrectomy syndrome 10.3 INS GCG
24 macular retinal edema 10.3 VEGFA INS
25 acute insulin response 10.3 INS GCG
26 alzheimer disease 6 10.3 INS GCG
27 anorexia nervosa 10.3
28 pancreatic endocrine carcinoma 10.2 INS GCG
29 hyperinsulinemic hypoglycemia, familial, 6 10.2 INS GLUD2
30 diabetic polyneuropathy 10.2 VEGFA INS
31 diabetic autonomic neuropathy 10.2 INS GCG
32 chronic ulcer of skin 10.2 VEGFA INS
33 hydrocele 10.2 VEGFA EPPIN
34 dumping syndrome 10.2 INS GCG
35 somatostatinoma 10.2 INS GCG
36 hypopituitarism 10.2
37 persistent fetal circulation syndrome 10.2 VEGFA INS IGF2
38 functional gastric disease 10.1 INS GCG
39 colorectal adenoma 10.1 VEGFA INS IGF2
40 vein disease 10.1 VEGFA INS EPPIN
41 apnea, obstructive sleep 10.1 VEGFA INS GCG
42 adrenal cortex disease 10.1 INS IGF2 EPPIN
43 autonomic nervous system disease 10.1 INS GCG
44 adrenal gland disease 10.1 INS IGF2 EPPIN
45 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 10.1 HBA2 HBA1
46 alcohol dependence 10.1
47 benign mesothelioma 10.1
48 pancreatitis 10.1
49 benign pleural mesothelioma 10.1
50 adenoma 10.1

Comorbidity relations with Hypoglycemic Coma via Phenotypic Disease Network (PDN): (show all 20)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Bronchitis
Decubitus Ulcer Deficiency Anemia
Diabetic Polyneuropathy Familial Atrial Fibrillation
Heart Disease Hypertension, Essential
Hypoglycemia Hypothyroidism
Iron Deficiency Anemia Kidney Disease
Microvascular Complications of Diabetes 1 Peripheral Vascular Disease
Protein-Energy Malnutrition Respiratory Failure
Schizophreniform Disorder Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Hypoglycemic Coma:



Diseases related to Hypoglycemic Coma

Symptoms & Phenotypes for Hypoglycemic Coma

Symptoms:

12
  • coma
  • seizure
  • decreased cognition
  • aberrant behavior

GenomeRNAi Phenotypes related to Hypoglycemic Coma according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.6 DPP4
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.6 DPP4 EPPIN IGF2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.6 IGF2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.6 IGF2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.6 EPPIN
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-195 9.6 IGF2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.6 EPPIN
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.6 EPPIN
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.6 DPP4 EPPIN
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.6 IGF2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-79 9.6 IGF2
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.6 IGF2
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.6 DPP4 IGF2
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-94 9.6 EPPIN
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.6 DPP4

Drugs & Therapeutics for Hypoglycemic Coma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Islet Cell Transplantation in Patients With Type I Diabetes With Previous Kidney Transplantation Completed NCT00315588 Phase 2 Islet Transplantation

Search NIH Clinical Center for Hypoglycemic Coma

Genetic Tests for Hypoglycemic Coma

Anatomical Context for Hypoglycemic Coma

MalaCards organs/tissues related to Hypoglycemic Coma:

40
Brain, Pancreas, Liver, Kidney, Breast, Eye, Heart

Publications for Hypoglycemic Coma

Articles related to Hypoglycemic Coma:

(show top 50) (show all 430)
# Title Authors PMID Year
1
Comparison of HbA1c in Chinese patients with type 1 or type 2 diabetes randomized to twice daily insulin lispro low mix 25 or twice daily human insulin mix 30/70. 54 61
19951567 2009
2
Hypoglycemic coma secondary to big insulin-like growth factor II secretion by a giant phyllodes tumor of the breast. 54 61
17319862 2007
3
Severe hypoglycemic coma due to insulin autoimmune syndrome. 54 61
15759820 2005
4
Epidemiological assessment of 160 cases of insulin overdose recorded in a regional poisons unit. 54 61
15176650 2004
5
Drug-induced hypoglycemic coma in 102 diabetic patients. 54 61
9989540 1999
6
Previous episodes of hypoglycemic coma are not associated with permanent cognitive brain dysfunction in IDDM patients on intensive insulin treatment. 54 61
9836523 1998
7
Abnormal electroencephalogram at diagnosis of insulin-dependent diabetes mellitus may predict severe symptoms of hypoglycemia in children. 54 61
9842047 1998
8
Acute pulmonary edema caused by accidental aspiration of sweetened water in two cases of diabetes mellitus. 54 61
9868963 1998
9
Hypoglycemic coma associated with brain infarcts. 54 61
17895073 1998
10
Drug interactions in diabetic patients. The risk of losing glycemic control. 54 61
8446523 1993
11
Reactive hypoglycemic coma due to insulin autoimmune syndrome: case report and literature review. 54 61
1605150 1992
12
Increasing incidence of hypoglycemic coma in children with IDDM. 54 61
1797479 1991
13
Histopathological and immunohistochemical analysis of the cerebral white matter after transient hypoglycemia in rat. 61
31787662 2020
14
Activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodents. 61
31263107 2019
15
Deep coma in a child treated with propranolol for infantile hemangioma. 61
31266444 2019
16
Recurrent moderate hypoglycemia exacerbates oxidative damage and neuronal death leading to cognitive dysfunction after the hypoglycemic coma. 61
29047291 2019
17
Association of attention deficit hyperactivity disorder with recurrent hypoglycemia in type 1 diabetes mellitus. 61
29938875 2019
18
[Successful treatment of severe sulfonylurea-induced hypoglycemia by the subcutaneous administration of octreotide in an elderly patient with diabetes: A case report]. 61
31366755 2019
19
Magnetic resonance imaging changes in a 69-year old man with hypoglycemia induced brain injury: case report and literature review. 61
31223419 2019
20
Risk Factors for Hypoglycemic Coma: A Study of 33 Patients on Insulin Therapy Who Were Transported to the Hospital by Ambulance. 61
29780121 2018
21
Risk of recurrent severe hypoglycemia remains associated with a past history of severe hypoglycemia up to 4 years: Results from a large prospective contemporary pediatric cohort of the DPV initiative. 61
29218766 2018
22
Hypoglycemic Coma in a Hemodialysis Patient Receiving Blood Glucose-Lowering Therapy With the Single Agent Teneligliptin. 61
29581705 2018
23
Analysis of Risk Factors for Hypoglycemic Coma in 194 Patients with Type 2 Diabetes. 61
29180613 2017
24
Cognitive, neurophysiologic and metabolic sequelae of previous hypoglycemic coma revealed by hyperinsulinemic-hypoglycemic clamp in type 1 diabetic patients. 61
28589447 2017
25
ROS Production and ERK Activity Are Involved in the Effects of d-β-Hydroxybutyrate and Metformin in a Glucose Deficient Condition. 61
28335557 2017
26
Glycated hemoglobin A1c as a risk factor for severe hypoglycemia in pediatric type 1 diabetes. 61
26712064 2017
27
Hypoglycemic Coma Induced by the Use of Succinic Acid Cibenzoline in Frail Late-stage Elderly Subjects. 61
28626178 2017
28
[Hypoglycemic coma and co-trimoxazole in a nondiabetic patient]. 61
27039069 2016
29
Smartwatch's Application Algorithm to Prevent Sudden Death and Brain Damage in Hypoglycemic Coma. 61
26659660 2016
30
[Endocrine and Metabolic Emergencies; Points of Initial Management. Topics: VII. Hypoglycemic coma]. 61
27491262 2016
31
Capecitabine-induced leukoencephalopathy involving the bilateral corticospinal tracts. 61
27200161 2016
32
Chemical Composition and the Effect of Walnut Hydrosol on Glycemic Control of Patients With Type 1 Diabetes. 61
27335580 2016
33
Variability of Basal Rate Profiles in Insulin Pump Therapy and Association with Complications in Type 1 Diabetes Mellitus. 61
26938444 2016
34
Xiaoke Pill () and anti-diabetic drugs: A review on clinical evidence of possible herb-drug interactions. 61
26825080 2016
35
The availability and validity of safety information of over the counter herbal products for use in diabetes in Sri Lanka: A cross sectional study. 61
26649230 2015
36
Roving eye movements in a patient with hypoglycemic coma. 61
25984318 2015
37
Accuracy of blood glucose meters for self-monitoring affects glucose control and hypoglycemia rate in children and adolescents with type 1 diabetes. 61
25549283 2015
38
[Sulfonylurea]. 61
25812366 2015
39
Recurrent hypoglycemic coma as the initial and single clinical manifestation of advanced hepatocellular carcinoma. 61
25407746 2015
40
Reversible corona radiata diffusion restriction in hypoglycemic coma. 61
25553230 2015
41
Effects of Alda-1, an Aldehyde Dehydrogenase-2 Agonist, on Hypoglycemic Neuronal Death. 61
26083658 2015
42
Regional Assessment of Severe Hypoglycemic Coma Events in Finland. 61
27200578 2014
43
Hypoglycemic coma due to insulin autoimmune syndrome induced by methimazole: A rare case report. 61
25289063 2014
44
Hemoglobin A1c Levels and risk of severe hypoglycemia in children and young adults with type 1 diabetes from Germany and Austria: a trend analysis in a cohort of 37,539 patients between 1995 and 2012. 61
25289645 2014
45
Management of emergencies in general practice: role of general practitioners. 61
25657933 2014
46
[Endoscopic ultrasound-guided ethanol ablation: an alternative option for the treatment of pancreatic insulinoma]. 61
25282110 2014
47
Differential production of reactive oxygen species in distinct brain regions of hypoglycemic mice. 61
24590689 2014
48
[Diabetes emergencies]. 61
24820043 2014
49
Reversible severe hepatitis in anorexia nervosa: a case report and overview. 61
24445725 2014
50
Evaluation of the incidence and risk of hypoglycemic coma associated with selection of basal insulin in the treatment of diabetes: a Finnish register linkage study. 61
24150837 2013

Variations for Hypoglycemic Coma

Expression for Hypoglycemic Coma

Search GEO for disease gene expression data for Hypoglycemic Coma.

Pathways for Hypoglycemic Coma

GO Terms for Hypoglycemic Coma

Cellular components related to Hypoglycemic Coma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 VEGFA INS IGF2 HBA2 HBA1 GCG
2 endocytic vesicle lumen GO:0071682 9.32 HBA2 HBA1
3 hemoglobin complex GO:0005833 9.26 HBA2 HBA1
4 extracellular region GO:0005576 9.23 VEGFA INS IGF2 HBA2 HBA1 GCG
5 haptoglobin-hemoglobin complex GO:0031838 9.16 HBA2 HBA1

Biological processes related to Hypoglycemic Coma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.67 VEGFA INS IGF2 DPP4
2 hydrogen peroxide catabolic process GO:0042744 9.43 HBA2 HBA1
3 positive regulation of mitotic nuclear division GO:0045840 9.4 INS IGF2
4 positive regulation of insulin receptor signaling pathway GO:0046628 9.32 INS IGF2
5 positive regulation of protein autophosphorylation GO:0031954 9.26 VEGFA INS
6 positive regulation of glycogen biosynthetic process GO:0045725 9.16 INS IGF2
7 oxygen transport GO:0015671 8.96 HBA2 HBA1
8 regulation of insulin secretion GO:0050796 8.8 RAPGEF4 GCG DPP4

Molecular functions related to Hypoglycemic Coma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 9.46 HBA2 HBA1
2 receptor ligand activity GO:0048018 9.43 VEGFA IGF2
3 oxygen binding GO:0019825 9.4 HBA2 HBA1
4 insulin receptor binding GO:0005158 9.37 INS IGF2
5 hormone activity GO:0005179 9.33 INS IGF2 GCG
6 insulin-like growth factor receptor binding GO:0005159 9.32 INS IGF2
7 oxygen carrier activity GO:0005344 9.26 HBA2 HBA1
8 organic acid binding GO:0043177 8.96 HBA2 HBA1
9 haptoglobin binding GO:0031720 8.62 HBA2 HBA1

Sources for Hypoglycemic Coma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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