Aliases & Classifications for Hypoglycemic Coma

MalaCards integrated aliases for Hypoglycemic Coma:

Name: Hypoglycemic Coma 12 54 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1607
ICD9CM 34 251.0
SNOMED-CT 67 267384006
ICD10 32 E15
UMLS 71 C0020617

Summaries for Hypoglycemic Coma

Disease Ontology : 12 A brain disease that is characterized by coma or unconsciousness, develops from a prolonged insufficient supply of glucose to the brain, has symptom decreased cognition, has symptom aberrant behavior, has symptom seizure, and has symptom coma.

MalaCards based summary : Hypoglycemic Coma is related to insulinoma and hirata disease, and has symptoms including coma, seizure and decreased cognition. An important gene associated with Hypoglycemic Coma is INS (Insulin), and among its related pathways/superpathways are Peptide hormone metabolism and Development_Leptin signaling via JAK/STAT and MAPK cascades. Affiliated tissues include brain, liver and kidney.

Related Diseases for Hypoglycemic Coma

Diseases related to Hypoglycemic Coma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 insulinoma 30.7 INS IGF2 GCG
2 hirata disease 30.5 SI INS
3 potter's syndrome 30.5 INS IGF2
4 islet cell tumor 30.2 INS IGF2 GCG
5 hyperinsulinemic hypoglycemia 30.2 INS IGF2 GCG
6 gestational diabetes 30.1 INS IGF2 GCG
7 anorexia nervosa 29.9 POMC INS GCG
8 sheehan syndrome 29.9 POMC INS
9 empty sella syndrome 29.8 POMC INS
10 hypoglycemia 29.7 VEGFA POMC INS IGF2 GCG DPP4
11 hyperinsulinism 29.6 INS IGF2 GCG DPP4
12 multiple endocrine neoplasia, type i 29.5 POMC INS GCG
13 diabetes mellitus, ketosis-prone 29.3 SI INS GCG DPP4
14 prader-willi syndrome 29.2 POMC INS IGF2 GCG
15 inherited metabolic disorder 28.9 SI POMC INS GCG
16 diabetes mellitus 28.0 VEGFA POMC INS IGF2 HBA1 GCG
17 diabetes mellitus, type i 27.0 VEGFA SI POMC INS IGF2 HBA2
18 acyl-coa dehydrogenase, medium-chain, deficiency of 11.4
19 ocular motor apraxia 11.2
20 retroperitoneal hemangiopericytoma 10.4 VEGFA INS
21 retinal microaneurysm 10.4 VEGFA INS
22 severe nonproliferative diabetic retinopathy 10.4 VEGFA INS
23 type 1 diabetes mellitus 2 10.4 INS IGF2
24 background diabetic retinopathy 10.3 VEGFA INS
25 acute insulin response 10.3 INS GCG
26 fetal macrosomia 10.3 INS IGF2
27 choline deficiency disease 10.3 INS IGF2
28 decubitus ulcer 10.3 VEGFA INS
29 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 10.3 HBA2 HBA1
30 maturity-onset diabetes of the young, type 2 10.3 INS GCG
31 glutathione peroxidase deficiency 10.3 HBA2 HBA1
32 methemoglobinemia, beta-globin type 10.2 HBA2 HBA1
33 erythrocytosis, familial, 7 10.2 HBA2 HBA1
34 alpha thalassemia-intellectual disability syndrome type 1 10.2 HBA2 HBA1
35 macular retinal edema 10.2 VEGFA INS
36 ulcer of lower limbs 10.2 INS DPP4
37 splenic flexure cancer 10.2 INS DPP4
38 hydrocele 10.2 VEGFA EPPIN
39 diabetes mellitus, insulin-dependent, 24 10.2 HBA2 HBA1
40 hydrops fetalis, nonimmune 10.2 HBA2 HBA1
41 adenosquamous bile duct carcinoma 10.2 GCG DPP4
42 hypopituitarism 10.2
43 placenta disease 10.2 VEGFA INS IGF2
44 erythrocytosis, familial, 8 10.2 HBA2 HBA1
45 colorectal adenoma 10.2 VEGFA INS IGF2
46 pancreatic colloid cystadenoma 10.2 GCG DPP4
47 apnea, obstructive sleep 10.2 VEGFA INS GCG
48 somatostatinoma 10.2 INS GCG
49 diabetic cataract 10.1 VEGFA INS
50 gastrointestinal system benign neoplasm 10.1 INS IGF2 GCG

Comorbidity relations with Hypoglycemic Coma via Phenotypic Disease Network (PDN): (show all 20)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Bronchitis
Decubitus Ulcer Deficiency Anemia
Diabetic Polyneuropathy Familial Atrial Fibrillation
Heart Disease Hypertension, Essential
Hypoglycemia Hypothyroidism
Iron Deficiency Anemia Kidney Disease
Microvascular Complications of Diabetes 1 Peripheral Vascular Disease
Protein-Energy Malnutrition Respiratory Failure
Schizophreniform Disorder Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Hypoglycemic Coma:



Diseases related to Hypoglycemic Coma

Symptoms & Phenotypes for Hypoglycemic Coma

Symptoms:

12
  • coma
  • seizure
  • decreased cognition
  • aberrant behavior

Drugs & Therapeutics for Hypoglycemic Coma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Islet Cell Transplantation in Patients With Type I Diabetes With Previous Kidney Transplantation Completed NCT00315588 Phase 2 Islet Transplantation

Search NIH Clinical Center for Hypoglycemic Coma

Genetic Tests for Hypoglycemic Coma

Anatomical Context for Hypoglycemic Coma

MalaCards organs/tissues related to Hypoglycemic Coma:

40
Brain, Liver, Kidney, Pancreas, Eye, Cortex, Heart

Publications for Hypoglycemic Coma

Articles related to Hypoglycemic Coma:

(show top 50) (show all 432)
# Title Authors PMID Year
1
Comparison of HbA1c in Chinese patients with type 1 or type 2 diabetes randomized to twice daily insulin lispro low mix 25 or twice daily human insulin mix 30/70. 61 54
19951567 2009
2
Hypoglycemic coma secondary to big insulin-like growth factor II secretion by a giant phyllodes tumor of the breast. 61 54
17319862 2007
3
Severe hypoglycemic coma due to insulin autoimmune syndrome. 61 54
15759820 2005
4
Epidemiological assessment of 160 cases of insulin overdose recorded in a regional poisons unit. 54 61
15176650 2004
5
Drug-induced hypoglycemic coma in 102 diabetic patients. 61 54
9989540 1999
6
Previous episodes of hypoglycemic coma are not associated with permanent cognitive brain dysfunction in IDDM patients on intensive insulin treatment. 61 54
9836523 1998
7
Abnormal electroencephalogram at diagnosis of insulin-dependent diabetes mellitus may predict severe symptoms of hypoglycemia in children. 54 61
9842047 1998
8
Acute pulmonary edema caused by accidental aspiration of sweetened water in two cases of diabetes mellitus. 61 54
9868963 1998
9
Hypoglycemic coma associated with brain infarcts. 61 54
17895073 1998
10
Drug interactions in diabetic patients. The risk of losing glycemic control. 54 61
8446523 1993
11
Reactive hypoglycemic coma due to insulin autoimmune syndrome: case report and literature review. 54 61
1605150 1992
12
Increasing incidence of hypoglycemic coma in children with IDDM. 61 54
1797479 1991
13
Temporal analysis of histopathology and cytokine expression in the rat cerebral cortex after insulin-induced hypoglycemia. 61
32080930 2020
14
Isolated Adrenocorticotropic Hormone Deficiency and Primary Hypothyroidism in a Patient Undergoing Long-Term Hemodialysis: A Case Report and Literature Review. 61
32343680 2020
15
Histopathological and immunohistochemical analysis of the cerebral white matter after transient hypoglycemia in rat. 61
31787662 2020
16
Deep coma in a child treated with propranolol for infantile hemangioma. 61
31266444 2019
17
Activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodents. 61
31263107 2019
18
Recurrent moderate hypoglycemia exacerbates oxidative damage and neuronal death leading to cognitive dysfunction after the hypoglycemic coma. 61
29047291 2019
19
Association of attention deficit hyperactivity disorder with recurrent hypoglycemia in type 1 diabetes mellitus. 61
29938875 2019
20
[Successful treatment of severe sulfonylurea-induced hypoglycemia by the subcutaneous administration of octreotide in an elderly patient with diabetes: A case report]. 61
31366755 2019
21
Magnetic resonance imaging changes in a 69-year old man with hypoglycemia induced brain injury: case report and literature review. 61
31223419 2019
22
Risk Factors for Hypoglycemic Coma: A Study of 33 Patients on Insulin Therapy Who Were Transported to the Hospital by Ambulance. 61
29780121 2018
23
Risk of recurrent severe hypoglycemia remains associated with a past history of severe hypoglycemia up to 4 years: Results from a large prospective contemporary pediatric cohort of the DPV initiative. 61
29218766 2018
24
Hypoglycemic Coma in a Hemodialysis Patient Receiving Blood Glucose-Lowering Therapy With the Single Agent Teneligliptin. 61
29581705 2018
25
Analysis of Risk Factors for Hypoglycemic Coma in 194 Patients with Type 2 Diabetes. 61
29180613 2017
26
Cognitive, neurophysiologic and metabolic sequelae of previous hypoglycemic coma revealed by hyperinsulinemic-hypoglycemic clamp in type 1 diabetic patients. 61
28589447 2017
27
ROS Production and ERK Activity Are Involved in the Effects of d-β-Hydroxybutyrate and Metformin in a Glucose Deficient Condition. 61
28335557 2017
28
Glycated hemoglobin A1c as a risk factor for severe hypoglycemia in pediatric type 1 diabetes. 61
26712064 2017
29
Hypoglycemic Coma Induced by the Use of Succinic Acid Cibenzoline in Frail Late-stage Elderly Subjects. 61
28626178 2017
30
[Hypoglycemic coma and co-trimoxazole in a nondiabetic patient]. 61
27039069 2016
31
Smartwatch's Application Algorithm to Prevent Sudden Death and Brain Damage in Hypoglycemic Coma. 61
26659660 2016
32
[Endocrine and Metabolic Emergencies; Points of Initial Management. Topics: VII. Hypoglycemic coma]. 61
27491262 2016
33
Capecitabine-induced leukoencephalopathy involving the bilateral corticospinal tracts. 61
27200161 2016
34
Chemical Composition and the Effect of Walnut Hydrosol on Glycemic Control of Patients With Type 1 Diabetes. 61
27335580 2016
35
Xiaoke Pill () and anti-diabetic drugs: A review on clinical evidence of possible herb-drug interactions. 61
26825080 2016
36
Variability of Basal Rate Profiles in Insulin Pump Therapy and Association with Complications in Type 1 Diabetes Mellitus. 61
26938444 2016
37
The availability and validity of safety information of over the counter herbal products for use in diabetes in Sri Lanka: A cross sectional study. 61
26649230 2015
38
Roving eye movements in a patient with hypoglycemic coma. 61
25984318 2015
39
Accuracy of blood glucose meters for self-monitoring affects glucose control and hypoglycemia rate in children and adolescents with type 1 diabetes. 61
25549283 2015
40
[Sulfonylurea]. 61
25812366 2015
41
Recurrent hypoglycemic coma as the initial and single clinical manifestation of advanced hepatocellular carcinoma. 61
25407746 2015
42
Reversible corona radiata diffusion restriction in hypoglycemic coma. 61
25553230 2015
43
Effects of Alda-1, an Aldehyde Dehydrogenase-2 Agonist, on Hypoglycemic Neuronal Death. 61
26083658 2015
44
Regional Assessment of Severe Hypoglycemic Coma Events in Finland. 61
27200578 2014
45
Hypoglycemic coma due to insulin autoimmune syndrome induced by methimazole: A rare case report. 61
25289063 2014
46
Hemoglobin A1c Levels and risk of severe hypoglycemia in children and young adults with type 1 diabetes from Germany and Austria: a trend analysis in a cohort of 37,539 patients between 1995 and 2012. 61
25289645 2014
47
Management of emergencies in general practice: role of general practitioners. 61
25657933 2014
48
[Endoscopic ultrasound-guided ethanol ablation: an alternative option for the treatment of pancreatic insulinoma]. 61
25282110 2014
49
Differential production of reactive oxygen species in distinct brain regions of hypoglycemic mice. 61
24590689 2014
50
[Diabetes emergencies]. 61
24820043 2014

Variations for Hypoglycemic Coma

Expression for Hypoglycemic Coma

Search GEO for disease gene expression data for Hypoglycemic Coma.

Pathways for Hypoglycemic Coma

GO Terms for Hypoglycemic Coma

Cellular components related to Hypoglycemic Coma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 VEGFA POMC INS IGF2 HBA2 HBA1
2 secretory granule lumen GO:0034774 9.5 POMC INS GCG
3 endocytic vesicle lumen GO:0071682 9.37 HBA2 HBA1
4 extracellular region GO:0005576 9.28 VEGFA POMC INS IGF2 HBA2 HBA1
5 hemoglobin complex GO:0005833 9.26 HBA2 HBA1
6 haptoglobin-hemoglobin complex GO:0031838 9.16 HBA2 HBA1

Biological processes related to Hypoglycemic Coma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.71 VEGFA INS IGF2 DPP4
2 hydrogen peroxide catabolic process GO:0042744 9.37 HBA2 HBA1
3 positive regulation of mitotic nuclear division GO:0045840 9.32 INS IGF2
4 positive regulation of insulin receptor signaling pathway GO:0046628 9.26 INS IGF2
5 positive regulation of protein autophosphorylation GO:0031954 9.16 VEGFA INS
6 positive regulation of glycogen biosynthetic process GO:0045725 8.96 INS IGF2
7 oxygen transport GO:0015671 8.62 HBA2 HBA1

Molecular functions related to Hypoglycemic Coma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxygen binding GO:0019825 9.4 HBA2 HBA1
2 insulin receptor binding GO:0005158 9.37 INS IGF2
3 insulin-like growth factor receptor binding GO:0005159 9.32 INS IGF2
4 oxygen carrier activity GO:0005344 9.26 HBA2 HBA1
5 organic acid binding GO:0043177 9.16 HBA2 HBA1
6 haptoglobin binding GO:0031720 8.96 HBA2 HBA1
7 hormone activity GO:0005179 8.92 POMC INS IGF2 GCG

Sources for Hypoglycemic Coma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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