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MCID: HYP026
MIFTS: 37

Hypoglycemic Coma

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Hypoglycemic Coma

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MalaCards integrated aliases for Hypoglycemic Coma:

Name: Hypoglycemic Coma 12 54 15 71

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1607
ICD9CM 34 251.0
SNOMED-CT 67 267476006
ICD10 32 E15
UMLS 71 C0020617
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Summaries for Hypoglycemic Coma

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Disease Ontology : 12 A brain disease that is characterized by coma or unconsciousness, develops from a prolonged insufficient supply of glucose to the brain, has symptom decreased cognition, has symptom aberrant behavior, has symptom seizure, and has symptom coma.

MalaCards based summary : Hypoglycemic Coma is related to hirata disease and hypoglycemia, and has symptoms including coma, seizure and decreased cognition. An important gene associated with Hypoglycemic Coma is INS (Insulin), and among its related pathways/superpathways are Peptide hormone metabolism and African trypanosomiasis. Affiliated tissues include brain, pancreas and eye, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Hypoglycemic Coma

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Diseases related to Hypoglycemic Coma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
# Related Disease Score Top Affiliating Genes
1 hirata disease 30.5 SI INS
2 hypoglycemia 30.4 VEGFA INS IGF2 GCG DPP4
3 potter's syndrome 30.3 INS IGF2
4 islet cell tumor 30.0 INS IGF2 GCG
5 hyperinsulinemic hypoglycemia 30.0 INS IGF2 GCG
6 type 1 diabetes mellitus 29.8 VEGFA INS IGF2 HBA1 GCG
7 inherited metabolic disorder 29.8 SI INS GCG
8 hyperglycemia 29.4 INS GCG DPP4
9 hyperinsulinism 29.3 INS IGF2 GCG DPP4
10 diabetes mellitus, ketosis-prone 29.2 SI INS GCG DPP4
11 type 2 diabetes mellitus 28.7 VEGFA INS IGF2 HBA1 GCG DPP4
12 ocular motor apraxia 11.1
13 acyl-coa dehydrogenase, medium-chain, deficiency of 11.1
14 insulinoma 10.3
15 retroperitoneal hemangiopericytoma 10.3 VEGFA INS
16 rubeosis iridis 10.3 VEGFA INS
17 retinal microaneurysm 10.3 VEGFA INS
18 severe nonproliferative diabetic retinopathy 10.3 VEGFA INS
19 background diabetic retinopathy 10.3 VEGFA INS
20 type 1 diabetes mellitus 2 10.2 INS IGF2
21 decubitus ulcer 10.2 VEGFA INS
22 fetal macrosomia 10.2 INS IGF2
23 anorexia nervosa 10.2
24 hyperpituitarism 10.2 INS IGF2
25 acute insulin response 10.2 INS GCG
26 chronic ulcer of skin 10.2 VEGFA INS
27 pancreatic endocrine carcinoma 10.2 INS GCG
28 hydrocele 10.2 VEGFA EPPIN
29 dumping syndrome 10.2 INS GCG
30 macular retinal edema 10.2 VEGFA INS
31 hypopituitarism 10.2
32 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 10.2 HBA2 HBA1
33 glutathione peroxidase deficiency 10.1 HBA2 HBA1
34 immune hydrops fetalis 10.1 HBA2 HBA1
35 somatostatinoma 10.1 INS GCG
36 alpha thalassemia-intellectual disability syndrome type 1 10.1 HBA2 HBA1
37 erythrocytosis, familial, 7 10.1 HBA2 HBA1
38 persistent fetal circulation syndrome 10.1 VEGFA INS IGF2
39 methemoglobinemia, beta-globin type 10.1 HBA2 HBA1
40 sexual disorder 10.1 VEGFA INS EPPIN
41 placenta disease 10.1 VEGFA INS IGF2
42 vein disease 10.1 VEGFA INS EPPIN
43 type 1 diabetes mellitus 24 10.1 HBA2 HBA1
44 apnea, obstructive sleep 10.1 VEGFA INS GCG
45 adrenal cortex disease 10.1 INS IGF2 EPPIN
46 adrenal gland disease 10.1 INS IGF2 EPPIN
47 autonomic nervous system disease 10.1 INS GCG
48 alcohol dependence 10.1
49 benign mesothelioma 10.1
50 pancreatitis 10.1

Comorbidity relations with Hypoglycemic Coma via Phenotypic Disease Network (PDN): (show all 20)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Bronchitis
Decubitus Ulcer Deficiency Anemia
Diabetic Polyneuropathy Familial Atrial Fibrillation
Heart Disease Hypertension, Essential
Hypoglycemia Hypothyroidism
Iron Deficiency Anemia Kidney Disease
Microvascular Complications of Diabetes 1 Peripheral Vascular Disease
Protein-Energy Malnutrition Respiratory Failure
Schizophreniform Disorder Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Hypoglycemic Coma:



Diseases related to Hypoglycemic Coma
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Symptoms & Phenotypes for Hypoglycemic Coma

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Symptoms:

12
  • • coma
  • • seizure
  • • decreased cognition
  • • aberrant behavior

GenomeRNAi Phenotypes related to Hypoglycemic Coma according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-100 9.55 DPP4 EPPIN
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.55 EPPIN
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-132 9.55 IGF2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.55 EPPIN
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-168 9.55 IGF2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-24 9.55 DPP4
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-3 9.55 EPPIN
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-37 9.55 EPPIN
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.55 EPPIN
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.55 DPP4
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.55 EPPIN
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.55 IGF2
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-67 9.55 IGF2
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-74 9.55 IGF2
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-79 9.55 IGF2
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.55 IGF2
Sources

Drugs & Therapeutics for Hypoglycemic Coma

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Search Clinical Trials , NIH Clinical Center for Hypoglycemic Coma

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Genetic Tests for Hypoglycemic Coma

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Anatomical Context for Hypoglycemic Coma

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MalaCards organs/tissues related to Hypoglycemic Coma:

40
Brain, Pancreas, Eye, Cortex, Temporal Lobe, Kidney, Breast
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Publications for Hypoglycemic Coma

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Articles related to Hypoglycemic Coma:

(show top 50) (show all 439)
# Title Authors PMID Year
1
Comparison of HbA1c in Chinese patients with type 1 or type 2 diabetes randomized to twice daily insulin lispro low mix 25 or twice daily human insulin mix 30/70. 61 54
19951567 2009
2
Hypoglycemic coma secondary to big insulin-like growth factor II secretion by a giant phyllodes tumor of the breast. 61 54
17319862 2007
3
Severe hypoglycemic coma due to insulin autoimmune syndrome. 54 61
15759820 2005
4
Epidemiological assessment of 160 cases of insulin overdose recorded in a regional poisons unit. 54 61
15176650 2004
5
Drug-induced hypoglycemic coma in 102 diabetic patients. 61 54
9989540 1999
6
Hypoglycemic coma associated with brain infarcts. 61 54
17895073 1998
7
Drug interactions in diabetic patients. The risk of losing glycemic control. 61 54
8446523 1993
8
Reactive hypoglycemic coma due to insulin autoimmune syndrome: case report and literature review. 61 54
1605150 1992
9
Increasing incidence of hypoglycemic coma in children with IDDM. 54 61
1797479 1991
10
Temporal analysis of histopathology and cytokine expression in the rat cerebral cortex after insulin-induced hypoglycemia. 61
32080930 2020
11
Isolated Adrenocorticotropic Hormone Deficiency and Primary Hypothyroidism in a Patient Undergoing Long-Term Hemodialysis: A Case Report and Literature Review. 61
32343680 2020
12
Effect of β-Hydroxybutyrate on Autophagy Dynamics During Severe Hypoglycemia and the Hypoglycemic Coma. 61
33173467 2020
13
Histopathological and immunohistochemical analysis of the cerebral white matter after transient hypoglycemia in rat. 61
31787662 2020
14
Activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodents. 61
31263107 2019
15
Deep coma in a child treated with propranolol for infantile hemangioma. 61
31266444 2019
16
Recurrent moderate hypoglycemia exacerbates oxidative damage and neuronal death leading to cognitive dysfunction after the hypoglycemic coma. 61
29047291 2019
17
Association of attention deficit hyperactivity disorder with recurrent hypoglycemia in type 1 diabetes mellitus. 61
29938875 2019
18
[Successful treatment of severe sulfonylurea-induced hypoglycemia by the subcutaneous administration of octreotide in an elderly patient with diabetes: A case report]. 61
31366755 2019
19
Magnetic resonance imaging changes in a 69-year old man with hypoglycemia induced brain injury: case report and literature review. 61
31223419 2019
20
Risk Factors for Hypoglycemic Coma: A Study of 33 Patients on Insulin Therapy Who Were Transported to the Hospital by Ambulance. 61
29780121 2018
21
Risk of recurrent severe hypoglycemia remains associated with a past history of severe hypoglycemia up to 4 years: Results from a large prospective contemporary pediatric cohort of the DPV initiative. 61
29218766 2018
22
Hypoglycemic Coma in a Hemodialysis Patient Receiving Blood Glucose-Lowering Therapy With the Single Agent Teneligliptin. 61
29581705 2018
23
Analysis of Risk Factors for Hypoglycemic Coma in 194 Patients with Type 2 Diabetes. 61
29180613 2017
24
Cognitive, neurophysiologic and metabolic sequelae of previous hypoglycemic coma revealed by hyperinsulinemic-hypoglycemic clamp in type 1 diabetic patients. 61
28589447 2017
25
ROS Production and ERK Activity Are Involved in the Effects of d-β-Hydroxybutyrate and Metformin in a Glucose Deficient Condition. 61
28335557 2017
26
Glycated hemoglobin A1c as a risk factor for severe hypoglycemia in pediatric type 1 diabetes. 61
26712064 2017
27
Hypoglycemic Coma Induced by the Use of Succinic Acid Cibenzoline in Frail Late-stage Elderly Subjects. 61
28626178 2017
28
[Hypoglycemic coma and co-trimoxazole in a nondiabetic patient]. 61
27039069 2016
29
Smartwatch's Application Algorithm to Prevent Sudden Death and Brain Damage in Hypoglycemic Coma. 61
26659660 2016
30
[Endocrine and Metabolic Emergencies; Points of Initial Management. Topics: VII. Hypoglycemic coma]. 61
27491262 2016
31
Capecitabine-induced leukoencephalopathy involving the bilateral corticospinal tracts. 61
27200161 2016
32
Variability of Basal Rate Profiles in Insulin Pump Therapy and Association with Complications in Type 1 Diabetes Mellitus. 61
26938444 2016
33
Xiaoke Pill () and anti-diabetic drugs: A review on clinical evidence of possible herb-drug interactions. 61
26825080 2016
34
Chemical Composition and the Effect of Walnut Hydrosol on Glycemic Control of Patients With Type 1 Diabetes. 61
27335580 2016
35
The availability and validity of safety information of over the counter herbal products for use in diabetes in Sri Lanka: A cross sectional study. 61
26649230 2015
36
Roving eye movements in a patient with hypoglycemic coma. 61
25984318 2015
37
Accuracy of blood glucose meters for self-monitoring affects glucose control and hypoglycemia rate in children and adolescents with type 1 diabetes. 61
25549283 2015
38
[Sulfonylurea]. 61
25812366 2015
39
Recurrent hypoglycemic coma as the initial and single clinical manifestation of advanced hepatocellular carcinoma. 61
25407746 2015
40
Reversible corona radiata diffusion restriction in hypoglycemic coma. 61
25553230 2015
41
Effects of Alda-1, an Aldehyde Dehydrogenase-2 Agonist, on Hypoglycemic Neuronal Death. 61
26083658 2015
42
Hypoglycemic coma due to insulin autoimmune syndrome induced by methimazole: A rare case report. 61
25289063 2014
43
Regional Assessment of Severe Hypoglycemic Coma Events in Finland. 61
27200578 2014
44
Hemoglobin A1c Levels and risk of severe hypoglycemia in children and young adults with type 1 diabetes from Germany and Austria: a trend analysis in a cohort of 37,539 patients between 1995 and 2012. 61
25289645 2014
45
[Endoscopic ultrasound-guided ethanol ablation: an alternative option for the treatment of pancreatic insulinoma]. 61
25282110 2014
46
Management of emergencies in general practice: role of general practitioners. 61
25657933 2014
47
Differential production of reactive oxygen species in distinct brain regions of hypoglycemic mice. 61
24590689 2014
48
[Diabetes emergencies]. 61
24820043 2014
49
Reversible severe hepatitis in anorexia nervosa: a case report and overview. 61
24445725 2014
50
Evaluation of the incidence and risk of hypoglycemic coma associated with selection of basal insulin in the treatment of diabetes: a Finnish register linkage study. 61
24150837 2013
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Variations for Hypoglycemic Coma

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Expression for Hypoglycemic Coma

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Search GEO for disease gene expression data for Hypoglycemic Coma.
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Pathways for Hypoglycemic Coma

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Pathways related to Hypoglycemic Coma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Peptide hormone metabolism 65
Show member pathways
 11.06 INS GCG DPP4
2
African trypanosomiasis 36
10.72 HBA2 HBA1
3
Erythrocytes take up carbon dioxide and release oxygen 65
Show member pathways
 10.5 HBA2 HBA1
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GO Terms for Hypoglycemic Coma

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Cellular components related to Hypoglycemic Coma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 VEGFA INS IGF2 HBA2 HBA1 GCG
2 endocytic vesicle lumen GO:0071682 9.32 HBA2 HBA1
3 hemoglobin complex GO:0005833 9.26 HBA2 HBA1
4 extracellular region GO:0005576 9.23 VEGFA INS IGF2 HBA2 HBA1 GCG
5 haptoglobin-hemoglobin complex GO:0031838 9.16 HBA2 HBA1

Biological processes related to Hypoglycemic Coma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.71 VEGFA INS IGF2 DPP4
2 positive regulation of protein kinase B signaling GO:0051897 9.54 VEGFA INS IGF2
3 positive regulation of mitotic nuclear division GO:0045840 9.46 INS IGF2
4 hydrogen peroxide catabolic process GO:0042744 9.43 HBA2 HBA1
5 positive regulation of insulin receptor signaling pathway GO:0046628 9.32 INS IGF2
6 positive regulation of protein autophosphorylation GO:0031954 9.26 VEGFA INS
7 positive regulation of glycogen biosynthetic process GO:0045725 9.16 INS IGF2
8 oxygen transport GO:0015671 8.96 HBA2 HBA1
9 positive regulation of MAPK cascade GO:0043410 8.8 VEGFA INS IGF2

Molecular functions related to Hypoglycemic Coma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 9.43 HBA2 HBA1
2 oxygen binding GO:0019825 9.4 HBA2 HBA1
3 insulin receptor binding GO:0005158 9.37 INS IGF2
4 hormone activity GO:0005179 9.33 INS IGF2 GCG
5 insulin-like growth factor receptor binding GO:0005159 9.32 INS IGF2
6 oxygen carrier activity GO:0005344 9.26 HBA2 HBA1
7 organic acid binding GO:0043177 8.96 HBA2 HBA1
8 haptoglobin binding GO:0031720 8.62 HBA2 HBA1
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Sources for Hypoglycemic Coma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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