MCID: HYP080
MIFTS: 51

Hypogonadism

Categories: Endocrine diseases

Aliases & Classifications for Hypogonadism

MalaCards integrated aliases for Hypogonadism:

Name: Hypogonadism 12 75 29 55 44 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:1924
MeSH 44 D007006
NCIt 50 C9227
SNOMED-CT 68 48130008
UMLS 72 C0020619

Summaries for Hypogonadism

Disease Ontology : 12 A gonadal disease that is characterized by diminished functional activity of the gonads.

MalaCards based summary : Hypogonadism is related to hypogonadotropic hypogonadism 23 without anosmia and hypogonadotropic hypogonadism 7 with or without anosmia. An important gene associated with Hypogonadism is GNRH1 (Gonadotropin Releasing Hormone 1), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Liraglutide and Dihydrotachysterol have been mentioned in the context of this disorder. Affiliated tissues include pituitary, bone and prostate, and related phenotypes are endocrine/exocrine gland and cellular

Wikipedia : 75 Hypogonadism means diminished functional activity of the gonads-the testes or the ovaries-that may... more...

Related Diseases for Hypogonadism

Diseases related to Hypogonadism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 907)
# Related Disease Score Top Affiliating Genes
1 hypogonadotropic hypogonadism 23 without anosmia 34.0 LHB GNRHR GNRH1
2 hypogonadotropic hypogonadism 7 with or without anosmia 33.4 TAC3 SPRY4 GNRHR GNRH1 FGFR1 FGF17
3 hypogonadotropism 32.4 KISS1R KISS1 GNRHR GNRH1
4 charge syndrome 31.9 PROKR2 PROK2 FGFR1 CHD7 ANOS1
5 pseudovaginal perineoscrotal hypospadias 30.9 LHCGR GNRH1
6 cryptorchidism, unilateral or bilateral 30.7 PROKR2 PROK2 GNRHR GNRH1 FGFR1 ANOS1
7 amenorrhea 30.4 LHCGR LHB GNRH1 FSHB
8 infertility 30.4 LHCGR LHB GNRH1 FSHB
9 precocious puberty 29.7 LHCGR KISS1R KISS1 GNRH1
10 normosmic congenital hypogonadotropic hypogonadism 29.4 TACR3 TAC3 SPRY4 PROKR2 PROK2 NSMF
11 central precocious puberty 29.2 KISS1R KISS1 GNRH1
12 kallmann syndrome 29.0 TACR3 TAC3 SPRY4 PROKR2 PROK2 NSMF
13 hypogonadotropic hypogonadism 28.7 TACR3 TAC3 SPRY4 PROKR2 PROK2 NSMF
14 gonadal disease 28.1 PROKR2 NR0B1 LHCGR KISS1R KISS1 GNRHR
15 hypogonadotropic hypogonadism 1 with or without anosmia 12.6
16 hypogonadotropic hypogonadism 21 with or without anosmia 12.6
17 hypogonadotropic hypogonadism 10 with or without anosmia 12.6
18 hypogonadotropic hypogonadism 8 with or without anosmia 12.6
19 hypogonadotropic hypogonadism 12 with or without anosmia 12.6
20 hypogonadotropic hypogonadism 20 with or without anosmia 12.6
21 hypogonadotropic hypogonadism 15 with or without anosmia 12.6
22 hypogonadotropic hypogonadism 11 with or without anosmia 12.6
23 hypogonadotropic hypogonadism 13 with or without anosmia 12.6
24 hypogonadotropic hypogonadism 16 with or without anosmia 12.6
25 hypogonadotropic hypogonadism 9 with or without anosmia 12.6
26 hypogonadotropic hypogonadism 14 with or without anosmia 12.6
27 hypogonadotropic hypogonadism 4 with or without anosmia 12.6
28 hypogonadotropic hypogonadism 17 with or without anosmia 12.6
29 hypogonadotropic hypogonadism 19 with or without anosmia 12.6
30 hypogonadotropic hypogonadism 22 with or without anosmia 12.6
31 hypogonadotropic hypogonadism 5 with or without anosmia 12.6
32 hypogonadotropic hypogonadism 18 with or without anosmia 12.6
33 hypogonadotropic hypogonadism 3 with or without anosmia 12.6
34 hypogonadotropic hypogonadism 2 with or without anosmia 12.6
35 hypogonadotropic hypogonadism 6 with or without anosmia 12.6
36 cardiomyopathy, dilated, with hypergonadotropic hypogonadism 12.6
37 leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism 12.5
38 hypogonadism, male 12.5
39 leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism 12.5
40 hypogonadotropic hypogonadism 24 without anosmia 12.5
41 deafness-hypogonadism syndrome 12.4
42 hydrocephalus obesity hypogonadism 12.4
43 moyamoya disease 4 with short stature, hypergonadotropic hypogonadism, and facial dysmorphism 12.3
44 boucher-neuhauser syndrome 12.3
45 woodhouse-sakati syndrome 12.2
46 gordon holmes syndrome 12.2
47 intellectual disability-dysmorphism-hypogonadism-diabetes mellitus syndrome 12.2
48 retinitis pigmentosa-intellectual disability-deafness-hypogonadism syndrome 12.2
49 hypergonadotropic hypogonadism and partial alopecia 12.2
50 retinitis pigmentosa, deafness, mental retardation, and hypogonadism 12.2

Graphical network of the top 20 diseases related to Hypogonadism:



Diseases related to Hypogonadism

Symptoms & Phenotypes for Hypogonadism

MGI Mouse Phenotypes related to Hypogonadism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.17 CHD7 FGFR1 FSHB GNRH1 GNRHR KISS1
2 cellular MP:0005384 10.1 CHD7 DCAF17 DUSP6 FGFR1 FSHB GNRHR
3 growth/size/body region MP:0005378 10.03 CHD7 DUSP6 FGFR1 GNRH1 GNRHR KISS1
4 homeostasis/metabolism MP:0005376 10 CHD7 DUSP6 FGFR1 FSHB GNRH1 GNRHR
5 digestive/alimentary MP:0005381 9.97 CHD7 FGFR1 GNRH1 GNRHR KISS1 KISS1R
6 nervous system MP:0003631 9.7 CHD7 FGF17 FGFR1 GNRH1 KISS1 KISS1R
7 reproductive system MP:0005389 9.5 CHD7 DCAF17 FGFR1 FSHB GNRH1 GNRHR

Drugs & Therapeutics for Hypogonadism

Drugs for Hypogonadism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 209)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Liraglutide Approved Phase 4 204656-20-2 44147092
2
Dihydrotachysterol Approved Phase 4 67-96-9 5311071 5281010
3
Metformin Approved Phase 4 657-24-9 4091 14219
4
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
5 Nutmeg Approved Phase 4
6
Menotropins Approved Phase 4 61489-71-2, 9002-68-0 5360545
7
N,N-dimethylarginine Experimental Phase 4 30315-93-6 123831
8 Deslorelin Investigational, Vet_approved Phase 4 57773-65-6
9 Incretins Phase 4
10 Hypoglycemic Agents Phase 4
11 Triptorelin Pamoate Phase 4
12 Luteolytic Agents Phase 4
13 Fenugreek Phase 4
14 Fenugreek seed meal Phase 4
15 Tranquilizing Agents Phase 4
16 Serotonin 5-HT2 Receptor Antagonists Phase 4
17 Serotonin Receptor Agonists Phase 4
18 Serotonin 5-HT1 Receptor Agonists Phase 4
19 Serotonin Antagonists Phase 4
20 Serotonin Agents Phase 4
21 Antipsychotic Agents Phase 4
22 Psychotropic Drugs Phase 4
23 Dopamine agonists Phase 4
24 Dopamine D2 Receptor Antagonists Phase 4
25 Dopamine Antagonists Phase 4
26 Antidepressive Agents Phase 4
27 Lipid Regulating Agents Phase 4
28 Rosuvastatin Calcium Phase 4 147098-20-2
29 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
30 Hypolipidemic Agents Phase 4
31 Anticholesteremic Agents Phase 4
32 Antimetabolites Phase 4
33 Mace Phase 4
34 Chorionic Gonadotropin Phase 4
35 Follicle Stimulating Hormone Phase 4
36 Pharmaceutical Solutions Phase 4
37 Phosphodiesterase Inhibitors Phase 4
38 Phosphodiesterase 5 Inhibitors Phase 4
39 Vasodilator Agents Phase 4
40 Vardenafil Dihydrochloride Phase 4
41
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
42
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
43
Bromocriptine Approved, Investigational Phase 3 25614-03-3 31101
44
Mirtazapine Approved Phase 3 61337-67-5, 85650-52-8 4205
45
Histamine Approved, Investigational Phase 3 51-45-6 774
46
Amphetamine Approved, Illicit, Investigational Phase 3 300-62-9 5826 3007
47
Alendronate Approved Phase 3 66376-36-1, 121268-17-5 2088
48
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
49
Tadalafil Approved, Investigational Phase 3 171596-29-5 110635
50
Zoledronic Acid Approved Phase 3 118072-93-8 68740

Interventional clinical trials:

(show top 50) (show all 392)
# Name Status NCT ID Phase Drugs
1 Human Menopausal Gonadotropin Combining With Human Chorionic Gonadotropin is Superior to Human Chorionic Gonadotropin in Therapeutic Efficacy in Adolescent Boys With Congenital Hypogonadotropic Hypogonadism Unknown status NCT02880280 Phase 4 Human Menopausal Gonadotropin;Human Chorionic Gonadotropin
2 The Effect of Testim and Training in a Population Based, Randomized, Placebo-controlled, Double-blinded Study of Hypogonadal Men Unknown status NCT00700024 Phase 4 Testim;placebo
3 Effect of Androgel on Inflammatory Mediators and Oxidative Stress in Type 2 Diabetic Males With Hypogonadism Unknown status NCT00350701 Phase 4 androgel;androgel 10g;placebo
4 Aromatase Inhibitors and Weight Loss in Severely Obese Hypogonadal Male Veterans (Pilot) Unknown status NCT02959853 Phase 4 Anastrazole
5 Study on the Efficacy and Safety of Pulsatile Gonadotropin Releasing Hormone Pump Treatment in Patients With Idiopathic Hypogonadotropic Hypogonadism Unknown status NCT02310074 Phase 4 Pulsatile Gonadotropin Releasing Hormone;Human chorionic gonadotropin;Urinary Follicle-Stimulating Hormone
6 Comparison of Assisted Reproductive Technology (ART) Outcomes Between Two Protocols of Induction of Ovulation by Using Recombinant Luteinizing Hormone (rLH) and Recombinant Follicle Stimulating Hormone (rFSH) in Patients With Hypogonadotropic Hypogonadism Unknown status NCT02140515 Phase 4 Lutropin alfa;Follitropin alfa and Lutropin alfa
7 Phase IV Study to Investigate the Effect of Testosterone Treatment on Paraoxonase Level in Male Patients With Hypogonadotrophic Hypogonadism Completed NCT01107067 Phase 4 Sustanon
8 Phase 4 Study of About the Effect of Testosterone Treatment on the Components of Metabolic Syndrome Completed NCT01160341 Phase 4 Testosteron
9 Effects of Three Different Medications on Metabolic Parameters and Testicular Volume in Patients With Hypogonadotropic Hypogonadism-Last Three Years Experience Completed NCT01601327 Phase 4 Testosterone enanthate (Sustanon 250 mg);Human chorionic gonadotropin (hCG) (Pregnyl 5000 IU);Testosteron gel (Testojel 50 mg)
10 Effects of Liraglutide and Testosterone Replacement Therapy on Features of Hypogonadism and Weight Loss in Obese Men With Persistent Features of Hypogonadism. Completed NCT03619330 Phase 4 liraglutide;Testosterone
11 Phase 4 Study of Effect of Testosteron Treatment on the Visceral Adiposity Index and Triglyceride/High-density Lipoprotein Cholesterol Ratio in the Congenital Hypogonadotropic Hypogonadism Completed NCT02111434 Phase 4 Testosterone
12 Phase 4 Study That Evaluates the Presence of Endothelial Dysfunction, Inflammation and Insulin Resistance in Male Subjects With Hypogonadotrophic Hypogonadism and Effects of Two Different Testosterone Replacement Regiments on These Parameters. Completed NCT02171390 Phase 4 Testosterone 250mg injection;Testosteron 50 mg transdermal gel
13 Phase 4 Study That Evaluates the Effects of Two Different Testosterone Replacement Regiments on Endothelial Dysfunction, Inflammation and Insulin Resistance in Male Subjects With Hypogonadotrophic Hypogonadism. Completed NCT01533129 Phase 4 Testogel 50 mg transdermal gel;Testosterone 250mg injection
14 The Effect of Testosterone Topical Solution (LY900011) in Hypogonadal Men With Suboptimal Response to a Topical Testosterone Gel Completed NCT01893281 Phase 4 Topical Testosterone Solution
15 Phase 4 Study That Compares the High Density Lipoprotein Cholesterol (HDL) Cholesterol Subgroups of the Patients With Congenital Hypogonadotrophic Hypogonadism With That of the Healthy Control Subjects, and Investigates the Effect of Testosterone Treatment on HDL Subgroups. Completed NCT01454011 Phase 4 Testosteron 250mg injection;Testosterone 50mg transdermal application
16 Study on Effects of Testosterone Replacement Therapy in Hypogonadal Type 2 Completed NCT03792321 Phase 4 Testosterone Undecanoate;Placebo
17 Efficacy and Safety of Human Chorionic Gonadotropin (HCG) and Follicle Stimulating Hormone (FSH) in the Treatment of Hypogonadotropic Hypogonadism Completed NCT01403532 Phase 4 Traditional intervention for HH using HCG and FSH;Sequential intervention for HH using HCG and FSH;Sequential intervention for HH using HCG and FSH plus zinc
18 Phase 4 Study of Effect of Testosteron Replacement Treatment on the Fibroblast Growth Factor-23, Asymmetric Dimethylarginine and Vitamin D Levels in the Congenital Hypogonadotropic Hypogonadism Completed NCT02111473 Phase 4 Testosterone
19 MRI Substudy; Metabolic Changes Due to Iatrogenic Hypogonadism in Patients With Prostate Cancer: Orchiectomy vs. Triptorelin Completed NCT02102646 Phase 4 Triptorelin
20 A Randomised, Double Blind, Placebo-controlled Parallel Study to Test the Effect of Testosterone Treatment on Peripheral Vascular Disease in Hypogonadal Men With Type 2 Diabetes Mellitus Completed NCT00355537 Phase 4 Testosterone;0.9% saline
21 A Randomised, Double Blind, Placebo Controlled, Parallel Pilot Study to Test the Effect of Testosterone Treatment on Peripheral Vascular Disease in Hypogonadal Men With Type 2 Diabetes Mellitus Completed NCT00504712 Phase 4 Testosterone;saline
22 Testosterone Replacement and Dutasteride Effectiveness (TRADE) Completed NCT00194675 Phase 4 Dutasteride;Testosterone gel;Placebo dutasteride
23 Effect of Testosterone Replacement on Insulin Resistance in Hypogonadal, Non-obese Men With Metabolic Syndrome Completed NCT00487734 Phase 4 Placebo for testosterone gel
24 A Randomized, Double-blind, Placebo Controlled Trial to Evaluate the Effects of Vitamin D Supplementation on Androgen Levels in Hypogonadal Men Completed NCT01748370 Phase 4 Vitamin D supplementation in hypogonadal men;Vitamin D supplementation in eugonadal men;Placebo hypogonadal;Placebo eugonadal
25 Phase IV Study of The Therapy of Long-acting Testosterone Undecanoate,1000mg in 4 ml Oily Solution for i.m.Injection(Nebido) as Mono or in Combination With PDE-5 Inhibitors in Hypogonadal Patients With Erectile Dysfunction Completed NCT00421460 Phase 4 Testosterone Undecanoate,1000mg
26 Testosterone Replacement in Metabolic Syndrome and Inflammation of Fat Tissue Completed NCT01123278 Phase 4 Testosterone;Placebo
27 A Randomised Double Blind Placebo Controlled, Parallel Pilot Study to Test the Effect of Testosterone Replacement on Glycaemic Control and Arterial Wall Properties of Hypogonadal Men With Type 2 Diabetes Treated With Insulin Completed NCT00349362 Phase 4 Testosterone;0.9% saline
28 Effect of Hypogonadotrophic Hypogonadism and Treatment With Testosterone on Insulin Sensitivity, Inflammation, Body Composition and Sexual Function in Obese and Type 2 Diabetic Men Completed NCT01127659 Phase 4 testosterone;placebo
29 Aripiprazole Treatment for Antipsychotic Induced Hyperprolactinaemia in Patients With Severe Mental Illness and Learning Disabilities Completed NCT01085383 Phase 4 Aripiprazole
30 Subcutaneous Testosterone Therapy in Men Compared to Intramuscular Testosterone Therapy in Men Completed NCT03091348 Phase 4 Testosterone
31 Testosterone Therapy of Men With Type 2 Diabetes Mellitus (T2DM) - a Randomised, Doubleblinded and Placebocontrolled Trial of Men With Subnormal Testosterone Levels and T2DM. Completed NCT01560546 Phase 4 Testosterone;Placebo
32 A 150-Day, Prospective, Phase 4, Open-Label Study, Evaluating Patient Satisfaction and Symptom Improvement When Treating Male Hypogonadism With Testosterone Nasal Gel (Natesto™) Completed NCT02937740 Phase 4 NATESTO Testosterone Nasal Gel
33 Dutasteride in Men Receiving Testosterone Therapy: Impact on Serum PSA, Testosterone, DHT Levels and Prostate Volume: "Implications for Prostate Safety" Completed NCT00752869 Phase 4 dutasteride;placebo
34 Effects of Testosterone on Myocardial Repolarization in Patients With Hypogonadism With/Without Chronic Heat Failure (NYHA Class I-II) Completed NCT03126656 Phase 4 Testosterone Undecanoate
35 Effectiveness of Testosterone Replacement Therapy (TRT) on Prostatic Gland in Hypogonadal Patients Affected by Benign Prostatic Hyperplasia (BPH) and Metabolic Syndrome (MetS). Florence-PROTEST Completed NCT02366975 Phase 4 Testosterone gel 2%
36 Statin Therapy is Associated With Low Testosterone and Sexual Function in Men With Type 2 Diabetes Completed NCT02612714 Phase 4 Rosuvastatin
37 To Define the Individual Need of Exogenous LH During Ovarian Stimulation for Severe LH Suppressed Patients After Administration of a GnRH Antagonist Completed NCT01936077 Phase 4 Recombinant LH (Luveris)
38 Estrogen Dosing in Turner Syndrome:Pharmacology & Metabolism Completed NCT00837616 Phase 4 17 B estradiol orally;17 B estradiol
39 Neuroendocrine Dysfunction in Traumatic Brain Injury: Effects of Testosterone Therapy Completed NCT01201863 Phase 4 Androgel (Testosterone Gel);Androgel Placebo
40 Efficacy and Safety of a Mixed Extract of Fenugreek Seed and Lespedeza Cuneata in the Treatment of Testosterone Deficiency Syndrome: A Randomized, Double-blind, Placebo-Controlled Clinical Trial Completed NCT03057899 Phase 4 TFG capsules (200 mg /capsule);Placebo oral capsule
41 Combined Influence of Puberty and Obesity on Insulin Resistance in Adolescents Completed NCT01775813 Phase 4 Metformin
42 Final Oocyte Maturation Via Administration of GnRH Agonists Followed By Luteal Support With hCG Completed NCT01638026 Phase 4 TRIPTORELIN ACETATE, hCG
43 Effects of Testosterone Replacement on Atherosclerosis Progression in Older Men With Low Testosterone Levels Completed NCT00287586 Phase 4 Testosterone Gel (Androgel);Placebo
44 FSH/LH Ratio as a Predictor of IVF Outcome in Young and Older Women Completed NCT02674178 Phase 4
45 An Integrated Approach With Vardenafil Orodispersible and Cognitive-behavioral Sex Therapy for the Treatment of Erectile Dysfunction (STEDOV) Completed NCT02450188 Phase 4 Vardenafil
46 Testosterone Replacement Therapy for Assessment of Long-term Vascular Events and Efficacy ResponSE in Hypogonadal Men (TRAVERSE) Study Recruiting NCT03518034 Phase 4 Testosterone;Placebo
47 The Effect of Testosterone Replacement in Patients With Hypogonadotrophic Hypogonadism Due to Opioid Treatment for Non-malignant Disease Recruiting NCT02433730 Phase 4 Testosterone;placebo
48 Natesto Effects on Testosterone, Luteinizing Hormone, Follicle Stimulating Hormone and Semen Parameters Recruiting NCT03203681 Phase 4 NATESTO® (4.5% nasal testosterone) Nasal Gel
49 Aromatase Inhibitors and Weight Loss in Severely Obese Men With Hypogonadism Recruiting NCT03490513 Phase 4 anastrozole (1 mg/day);Placebo
50 Clinical, Microbiologic and Immunologic Profile of the Periodontal Condition in Hypogonadic Men Recruiting NCT03176537 Phase 4 Testosterone gel;Placebos

Search NIH Clinical Center for Hypogonadism

Inferred drug relations via UMLS 72 / NDF-RT 51 :


2-Bromoergocryptine Mesylate
Black Cohosh Extract
Bromocriptine
Chlorotrianisene
Estradiol
Estradiol acetate
estradiol cypionate
ESTRADIOL PWDR
estradiol valerate
Estrogens
Estrogens, Conjugated (USP)
Estrogens, esterified
Estrogens, Esterified (USP)
Estrone
estropipate
Ethinyl Estradiol
Ethynodiol Diacetate
Fluoxymesterone
Lutropin alfa
Methyltestosterone
METHYLTESTOSTERONE PWDR
Norethindrone
norethindrone acetate
polyestradiol
polyestradiol phosphate
Sodium estrone sulfate
synthetic conjugated estrogens, A
synthetic conjugated estrogens, B
Testosterone
testosterone cypionate
testosterone enanthate
Testosterone Propionate
TESTOSTERONE PROPIONATE PWDR
TESTOSTERONE PWDR
testosterone undecanoate

Cochrane evidence based reviews: hypogonadism

Genetic Tests for Hypogonadism

Genetic tests related to Hypogonadism:

# Genetic test Affiliating Genes
1 Hypogonadism 29

Anatomical Context for Hypogonadism

MalaCards organs/tissues related to Hypogonadism:

41
Pituitary, Bone, Prostate, Testes, Brain, Liver, Testis

Publications for Hypogonadism

Articles related to Hypogonadism:

(showing 10009, show less)
# Title Authors PMID Year
1
Novel insights in FGFR1 regulation: lessons from Kallmann syndrome. 9 38
20117945 2010
2
Emotional disorders in testicular cancer survivors in relation to hypogonadism, androgen receptor polymorphism and treatment modality. 9 38
19656574 2010
3
[Case of progressive prostatic carcinoma in a patient with acquired hypogonadism]. 9 38
20448451 2010
4
A new FSHbeta mutation in a 29-year-old woman with primary amenorrhea and isolated FSH deficiency: functional characterization and ovarian response to human recombinant FSH. 9 38
19966036 2010
5
Management of erectile dysfunction. 9 38
20112889 2010
6
Recombinant follitropin alfa/lutropin alfa in fertility treatment. 9 38
20161981 2010
7
The relationship of testosterone to prostate-specific antigen in men with sexual dysfunction. 9 38
19912506 2010
8
Narrative review: the role of leptin in human physiology: emerging clinical applications. 9 38
20083828 2010
9
Hypogonadism, ED, metabolic syndrome and obesity: a pathological link supporting cardiovascular diseases. 9 38
19226407 2009
10
Prostate cancer and acromegaly. 9 38
20126848 2009
11
Relationship between insulin and hypogonadism in men with metabolic syndrome. 9 38
20126854 2009
12
Adiponectin and testosterone in patients with symptoms of late-onset hypogonadism: is there a link? 9 38
19719531 2009
13
Effects of rhIGF-1 administration on surrogate markers of bone turnover in adolescents with anorexia nervosa. 9 38
19523548 2009
14
Preservation of GHRH and GH-releasing peptide-2 efficacy in young men with experimentally induced hypogonadism. 9 38
19458139 2009
15
Dimeric PROP1 binding to diverse palindromic TAAT sequences promotes its transcriptional activity. 9 38
19524124 2009
16
Bone mineral density and disorders of mineral metabolism in chronic liver disease. 9 38
19630107 2009
17
The emerging link between hypogonadism and metabolic syndrome. 9 38
18772486 2009
18
Peptide YY in adolescent athletes with amenorrhea, eumenorrheic athletes and non-athletic controls. 9 38
19344792 2009
19
Prostate-specific antigen changes and prostate cancer in hypogonadal men treated with testosterone replacement therapy. 9 38
19154450 2009
20
Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout mice. 9 38
19176467 2009
21
Leptin: a pivotal regulator of human energy homeostasis. 9 38
19211814 2009
22
Gonadal function in male patients after treatment for malignant lymphomas, with emphasis on chemotherapy. 9 38
19156143 2009
23
Non-functioning pituitary adenomas: clinical feature, laboratorial and imaging assessment, therapeutic management and outcome. 9 38
19347183 2009
24
Inactivating mutations of luteinizing hormone beta-subunit or luteinizing hormone receptor cause oligo-amenorrhea and infertility in women. 9 38
19129711 2009
25
Has prolactin a role in the hypogonadal status of HIV-infected patients? 9 38
19171915 2009
26
FSHbeta gene mutation in a female with delayed puberty and hypogonadism: response to recombinant human FSH. 9 38
20067895 2009
27
Laboratory diagnosis of late-onset male hypogonadism andropause. 9 38
19197450 2008
28
Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients. 9 38
18854428 2008
29
Testosterone and erectile dysfunction. 9 38
18641415 2008
30
Endocrine and metabolic disorders in young adult survivors of childhood acute lymphoblastic leukaemia (ALL) or non-Hodgkin lymphoma (NHL). 9 38
18429947 2008
31
Relationship of prostate-specific antigen to age and testosterone in men with type 2 diabetes mellitus. 9 38
19095599 2008
32
[Long-term steroid therapy in children: is adjunct therapy relevant in nephrotic syndrome?]. 9 38
18951767 2008
33
Left ventricular dysfunction in Klinefelter syndrome is associated to insulin resistance, abdominal adiposity and hypogonadism. 9 38
18248650 2008
34
Acylated ghrelin and leptin in adolescent athletes with amenorrhea, eumenorrheic athletes and controls: a cross-sectional study. 9 38
18331605 2008
35
[Testosterone replacement in hypogonadotropic hypogonadal young male improves insulin sensitivity]. 9 38
19080648 2008
36
Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor. 9 38
18449947 2008
37
Bone density in the adolescent athlete. 9 38
18409004 2008
38
Kisspeptin and GPR54: discovery of a novel pathway in reproduction. 9 38
18601695 2008
39
Prevalence of metabolic syndrome in long-term survivors of hematopoietic stem cell transplantation. 9 38
18195686 2008
40
The ratio of serum testosterone-to-prostate specific antigen predicts prostate cancer in hypogonadal men. 9 38
18343420 2008
41
Prevalence of androgen deficiency in men with erectile dysfunction. 9 38
18313109 2008
42
[Phenotype of patients with gynecomastia]. 9 38
18465688 2008
43
Secondary hypothyroidism in hereditary hemochromatosis: recovery after iron depletion. 9 38
18205549 2008
44
The role of cyclase activating (CAP) and cyclase inhibiting (CIP) parathormone fractions in the assessment of bone metabolism disturbances in women with hyperprolactinemia of various origin. 9 38
18283239 2008
45
Seminiferous tubule function in delayed-onset X-linked adrenal hypoplasia congenita associated with incomplete hypogonadotrophic hypogonadism. 9 38
17803711 2008
46
The complex genetics of Kallmann syndrome: KAL1, FGFR1, FGF8, PROKR2, PROK2, et al. 9 38
18987492 2008
47
Cholestasis and metabolic bone disease - a clinical review. 9 38
18998071 2008
48
[Pathogenetically complicated case of osteoporosis in a young man]. 9 38
19097362 2008
49
Androgen deficiency as a predictor of metabolic syndrome in aging men: an opportunity for intervention? 9 38
18447401 2008
50
Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system. 9 38
19554077 2008
51
Metabolic syndrome and reproduction: I. testicular function. 9 38
18224542 2008
52
Bicycle riding, perineal trauma, and erectile dysfunction: data and solutions. 9 38
18042330 2007
53
Acute sex steroid withdrawal reduces insulin sensitivity in healthy men with idiopathic hypogonadotropic hypogonadism. 9 38
17726076 2007
54
Testosterone deficiency and the metabolic syndrome. 9 38
17558968 2007
55
Skeletal effects of long-term estrogen and testosterone replacement treatment in a man with congenital aromatase deficiency: evidences of a priming effect of estrogen for sex steroids action on bone. 9 38
17400043 2007
56
Therapeutic uses of aromatase inhibitors in men. 9 38
17940445 2007
57
Martsolf syndrome in Japanese siblings. 9 38
17394201 2007
58
Effects of testosterone on erectile function: implications for the therapy of erectile dysfunction. 9 38
17309554 2007
59
[Insulin-like growth factor I (IGF-I) and liver cirrhosis]. 9 38
17516829 2007
60
Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor. 9 38
17236139 2007
61
Clinical assessment and molecular analysis of GnRHR and KAL1 genes in males with idiopathic hypogonadotrophic hypogonadism. 9 38
17223984 2007
62
Growth hormone reserve in adult beta thalassemia patients. 9 38
17709895 2007
63
Role of endogenous androgen against insulin resistance and athero- sclerosis in men with type 2 diabetes. 9 38
18220653 2007
64
Testosterone replacement for hypogonadism after treatment of early prostate cancer with brachytherapy. 9 38
17183557 2007
65
Hypoandrogen-metabolic syndrome: a potentially common and underdiagnosed condition in men. 9 38
17263722 2007
66
Autosomal-recessive syndrome with alopecia, hypogonadism, progressive extra-pyramidal disorder, white matter disease, sensory neural deafness, diabetes mellitus, and low IGF1. 9 38
17167799 2007
67
Clinical effects of treatment for hypogonadism in male adolescents with Prader-Labhart-Willi syndrome. 9 38
17374959 2007
68
Hypogonadism and reduced bone mineral density in heterozygous H63D mutation in the HFE gene: an unusual presentation of hereditary hemochromatosis. 9 38
16988327 2007
69
Use of cognitive behavior therapy for functional hypothalamic amenorrhea. 9 38
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70
PROP1 gene analysis in Portuguese patients with combined pituitary hormone deficiency. 9 38
16984240 2006
71
Treatment-related osteoporosis in men with prostate cancer. 9 38
17062721 2006
72
Hormonal control of inhibin B in men. 9 38
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73
The evolving role of testosterone in the treatment of erectile dysfunction. 9 38
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74
The impact of genotype on endocrine complications in thalassaemia major. 9 38
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75
[Hypogonadism may cause insulin resistance in young males]. 9 38
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76
Prostate-specific antigen testing in hypogonadism: implications for the safety of testosterone-replacement therapy. 9 38
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77
[Gene as a cause of adrenal hypoplasia, hypogonadism and short height novel mutation of DAX-1 gene (pGly168fsX17)]. 9 38
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78
Hypogonadism in male patients with cancer. 9 38
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Prostatic cancer, hypogonadism, and insulin resistance: A case report. 9 38
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Characteristic features of 20 patients with Sheehan's syndrome. 9 38
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81
Hypothalamic and gonadal components of hypogonadism in boys with Prader-Labhart- Willi syndrome. 9 38
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82
Hyperglycemia and insulin resistance in men with prostate carcinoma who receive androgen-deprivation therapy. 9 38
16388523 2006
83
A rational approach to androgen therapy for hypogonadal men with prostate cancer. 9 38
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84
Therapy Insight: osteoporosis during hormone therapy for prostate cancer. 9 38
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85
Testosterone therapy in erectile dysfunction and hypogonadism. 9 38
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[The application of gonadotropin in treatment of male central hypogonadism]. 9 38
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Ovulation induction: a mini review. 9 38
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[GnRH resistance and the GPR54 gene]. 9 38
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89
Regulation of expression of mammalian gonadotrophin-releasing hormone receptor genes. 9 38
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Hyperprolactinaemia in 271 women: up to three decades of clinical follow-up. 9 38
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91
Hypogonadism and metabolic syndrome: implications for testosterone therapy. 9 38
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92
Effect of gender and gonadal status on the long-term response to somatostatin analogue treatment in acromegaly. 9 38
16117824 2005
93
Oxytocin mediates the estrogen-dependent contractile activity of endothelin-1 in human and rabbit epididymis. 9 38
15860558 2005
94
Effect of gonadotropin-releasing-hormone-induced hypogonadism on insulin action as assessed by euglycemic clamp studies in men. 9 38
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95
Sex steroids and sexual desire in a man with a novel mutation of aromatase gene and hypogonadism. 9 38
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96
Increasing insulin resistance is associated with a decrease in Leydig cell testosterone secretion in men. 9 38
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97
Hypogonadism in hereditary hemochromatosis. 9 38
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98
A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation. 9 38
15625238 2005
99
Prostatic specific antigen in patients with hypogonadism: effect of testosterone replacement. 9 38
16422891 2005
100
Antipsychotic drugs: a new risk factor for osteoporosis in young women with schizophrenia? 9 38
15643097 2005
101
Effect of aromatase inhibition on lipids and inflammatory markers of cardiovascular disease in elderly men with low testosterone levels. 9 38
15670201 2005
102
Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. 9 38
15665093 2005
103
Dominant transmission of prepubertal gynecomastia due to serum estrone excess: hormonal, biochemical, and genetic analysis in a large kindred. 9 38
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104
Kallmann syndrome: 14 novel mutations in KAL1 and FGFR1 (KAL2). 9 38
15605412 2005
105
Selective estrogen receptor modulators to prevent treatment-related osteoporosis. 9 38
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106
Prevalence of osteopenia in men with prolactinoma. 9 38
15816365 2005
107
Endocrine alterations in critically ill patients with stroke during the early recovery period. 9 38
16377833 2005
108
The effect of testosterone supplement on insulin sensitivity, glucose effectiveness, and acute insulin response after glucose load in male type 2 diabetics. 9 38
16353672 2005
109
Human chorionic gonadotropin therapy in adolescent boys with constitutional delayed puberty vs those with beta-thalassemia major. 9 38
15562375 2005
110
Acromegaly: effects on bone metabolism and mass. 9 38
16550720 2005
111
High incidence of neuroendocrine dysfunction in long-term survivors of aneurysmal subarachnoid hemorrhage. 9 38
15499033 2004
112
A novel polymerase gamma mutation in a family with ophthalmoplegia, neuropathy, and Parkinsonism. 9 38
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113
Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetes. 9 38
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114
[Hormone therapy in the aging male. Estrogen, DHEA, melatonin, somatotropin]. 9 38
15309306 2004
115
Impaired insulin secretion in the Turner metabolic syndrome. 9 38
15240640 2004
116
Endocrine aspects of sexual dysfunction in men. 9 38
16422986 2004
117
Occurrence of pituitary dysfunction following traumatic brain injury. 9 38
15253797 2004
118
The formation of an intrachain disulfide bond in the leptin protein is necessary for efficient leptin secretion. 9 38
15358050 2004
119
Effect of gonadotropin-releasing hormone hypogonadism on insulin action as assessed by hyperglycemic clamp studies in men. 9 38
15066469 2004
120
[Three patients with gynaecomastia]. 9 38
15141644 2004
121
Elevated leptin fragments in renal failure correlate with BMI and haematopoiesis and are normalized by haemodialysis. 9 38
15049957 2004
122
Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. 9 38
15070752 2004
123
Misrouted cell surface GnRH receptors as a disease aetiology for congenital isolated hypogonadotrophic hypogonadism. 9 38
15073146 2004
124
Effects of aromatase inhibition in elderly men with low or borderline-low serum testosterone levels. 9 38
15001605 2004
125
Clinical and molecular analysis of human reproductive disorders in Brazilian patients. 9 38
14689055 2004
126
Pulsatile gonadotrophin releasing hormone for ovulation induction in subfertility associated with polycystic ovary syndrome. 9 38
14973957 2004
127
Antipsychotic-induced hyperprolactinaemia: mechanisms, clinical features and management. 9 38
15456328 2004
128
Clinical-biochemical correlations in acromegaly at diagnosis and the real prevalence of biochemically discordant disease. 9 38
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129
Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. 9 38
14617756 2003
130
Hypothyroidism associated with anti-human chorionic gonadotropin antibodies secondarily produced by gonadotropin therapy in a case of idiopathic hypothalamic hypogonadism. 9 38
15008254 2003
131
Clinical and molecular genetics of the human GnRH receptor. 9 38
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132
Endocrine effects of nasal continuous positive airway pressure in male patients with obstructive sleep apnoea. 9 38
14535966 2003
133
Risk factors for male osteoporosis. 9 38
14670549 2003
134
Leptin concentrations in semen are correlated with serum leptin and elevated in hypergonadotrophic hypogonadism. 9 38
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135
Growth retardation, developmental delay, distinctive face, multiple endocrine abnormalities, and adenylyl cyclase dysfunction: a new syndrome? 9 38
12838561 2003
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Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome: time to review diagnostic criteria? 9 38
12843157 2003
137
Molecular pathogenesis of lipoid adrenal hyperplasia and adrenal hypoplasia congenita. 9 38
12943739 2003
138
Steroids in adult men with type 1 diabetes: a tendency to hypogonadism. 9 38
12766115 2003
139
Changes in serum leptin levels during GnRH agonist therapy. 9 38
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140
Mono-ovulatory cycles: a key goal in profertility programmes. 9 38
12859047 2003
141
Prostate cancer in patients with Hansen's disease. 9 38
12622716 2003
142
Analysis of the Cys82Arg mutation in follicle-stimulating hormone beta (FSHbeta) using a novel FSH expression vector. 9 38
12568849 2003
143
A novel loss of function mutation in exon 10 of the FSH receptor gene causing hypergonadotrophic hypogonadism: clinical and molecular characteristics. 9 38
12571157 2003
144
Pituitary tumor endocrinopathies and their endocrine evaluation. 9 38
12690978 2003
145
The pleiotropic expression of the myotonic dystrophy protein kinase gene illustrates the complex relationships between genetic, biological and clinical covariates of male aging. 9 38
12630069 2002
146
Maintenance of spermatogenesis in hypogonadotropic hypogonadal men with human chorionic gonadotropin alone. 9 38
12444893 2002
147
Prostate-specific antigen changes in hypogonadal men treated with testosterone replacement. 9 38
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148
The effects of gender and gonadal steroids on the neuroendocrine and temperature response to m-chlorophenylpiperazine in leuprolide-induced hypogonadism in women and men. 9 38
12431854 2002
149
The novel use of very high doses of cabergoline and a combination of testosterone and an aromatase inhibitor in the treatment of a giant prolactinoma. 9 38
12364416 2002
150
Progressive onset of adrenal insufficiency and hypogonadism of pituitary origin caused by a complex genetic rearrangement within DAX-1. 9 38
12213854 2002
151
Hypoparathyroidism in transfusion-dependent patients with beta-thalassemia. 9 38
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152
GnRH neuronal development: insights into hypogonadotrophic hypogonadism. 9 38
11893524 2002
153
Endocrine and metabolic abnormalities involved in obesity associated with typical antipsychotic drug administration. 9 38
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154
Depression: a major, unrecognized risk factor for osteoporosis? 9 38
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155
Neurophysiological regulation and target-tissue impact of the pulsatile mode of growth hormone secretion in the human. 9 38
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156
Pituitary prolactin-secreting macroadenoma combined with bilateral breast cancer in a 45-year-old male. 9 38
11434671 2001
157
Recombinant human growth hormone and recombinant human insulin-like growth factor I diminish the catabolic effects of hypogonadism in man: metabolic and molecular effects. 9 38
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158
A novel homozygous mutation in the second transmembrane domain of the gonadotrophin releasing hormone receptor gene. 9 38
11318785 2001
159
The 'hook effect' on serum prolactin estimation in a patient with macroprolactinoma. 9 38
11303248 2001
160
Hypogonadism in patients with acromegaly: data from the multi-centre acromegaly registry pilot study. 9 38
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161
Central control of bone formation. 9 38
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162
Use of the dopamine agonists bromocriptine and cabergoline in the management of risperidone-induced hyperprolactinemia in patients with psychotic disorders. 9 38
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163
Reproductive hormones after pancreas transplantation. 9 38
11063337 2000
164
Adipocyte insulin action in hypogonadotrophic hypogonadism. 9 38
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X-linked congenital adrenal hypoplasia: new mutations and long-term follow-up in three patients. 9 38
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166
Prolonged activation of the hypothalamus-pituitary-gonadal axis in a child with X-linked adrenal hypoplasia congenita. 9 38
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167
Testosterone modulates serum leptin concentrations in a male patient with hypothalamic hypogonadism. 9 38
10853711 2000
168
Multiple endocrine abnormalities in a child with Blackfan-Diamond anemia and hemochromatosis. Significant improvement of growth velocity and predicted adult height following growth hormone treatment despite liver damage. 9 38
10714760 2000
169
Endocrine status in elderly men with lower urinary tract symptoms: correlation of age, hormonal status, and lower urinary tract function. The Prostate Study Group of the Austrian Society of Urology. 9 38
10699620 2000
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Testosterone treatment in hypogonadal men: prostate-specific antigen level and risk of prostate cancer. 9 38
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Pulsatile luteinising hormone releasing hormone for ovulation induction in subfertility associated with polycystic ovary syndrome. 9 38
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[The significance of the androgen-estrogen ratios in the clinical picture of sexual disorders in men]. 9 38
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[Pathologic manifestations of hormonal receptor mutations]. 9 38
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Prevalence of endocrine dysfunction in HIV-infected men. 9 38
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Fasting hyperinsulinemia in human immunodeficiency virus-infected men: relationship to body composition, gonadal function, and protease inhibitor use. 9 38
10634360 2000
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Obesity in the Prader-Labhart-Willi syndrome is not due to leptin deficiency but is accentuated by hypogonadism in male patients. 9 38
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177
Combined pituitary hormone deficiency: role of Pit-1 and Prop-1. 9 38
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Male pseudohermaphroditism due to inactivating luteinizing hormone receptor mutations. 9 38
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The effects of treatment and the individual responsiveness to growth hormone (GH) replacement therapy in 665 GH-deficient adults. KIMS Study Group and the KIMS International Board. 9 38
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Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. 9 38
10523015 1999
181
Combined hypothalamic-pituitary-gonadal defect in a hypogonadic man with a novel mutation in the DAX-1 gene. 9 38
10522996 1999
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Physiologic and genetic insights into the pathophysiology and management of hypogonadotropic hypogonadism. 9 38
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183
GH/IGF-I axis in azoospermia in primary and secondary hypogonadism: a study before and during replacement therapy. 9 38
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184
A microdeletion within DAX-1 in X-linked adrenal hypoplasia congenita and hypogonadotrophic hypogonadism. 9 38
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185
Relationship between hormone levels and testicular biopsies of azoospermic men. 9 38
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186
Clinical endocrinology of human leptin. 9 38
10193859 1999
187
The same molecular defects of the gonadotropin-releasing hormone receptor determine a variable degree of hypogonadism in affected kindred. 9 38
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188
Novel DAX1 mutations in X-linked adrenal hypoplasia congenita and hypogonadotrophic hypogonadism. 9 38
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189
Intracerebral Whipple's disease diagnosed by stereotactic biopsy: a case report and review of the literature. 9 38
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190
Effects of androgen administration on the growth hormone-insulin-like growth factor I axis in men with acquired immunodeficiency syndrome wasting. 9 38
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Effect of testosterone replacement on whole body glucose utilisation and other cardiovascular risk factors in males with idiopathic hypogonadotrophic hypogonadism. 9 38
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192
Pulsatile GnRH or human chorionic gonadotropin/human menopausal gonadotropin as effective treatment for men with hypogonadotropic hypogonadism: a review of 42 cases. 9 38
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193
Proteinuria, hypertension and chronic renal failure in X-linked Kallmann's syndrome, a defined genetic cause of solitary functioning kidney. 9 38
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Gonadotropin-releasing hormone receptor gene mutation: a new cause of hereditary hypogonadism and another mutated G-protein-coupled receptor. 9 38
9678526 1998
195
Hyperleptinaemia is associated with impaired gonadotrophin response to GnRH during late puberty in obese girls, not boys. 9 38
9678532 1998
196
Mid-follicular phase pulses of inhibin B are absent in polycystic ovarian syndrome and are initiated by successful laparoscopic ovarian diathermy: a possible mechanism regulating emergence of the dominant follicle. 9 38
9589683 1998
197
Hypothalamic amenorrhea and cardiovascular hormones: changes of plasma calcitonin gene-related peptide and atrial natriuretic peptide levels. 9 38
9624600 1998
198
A leptin missense mutation associated with hypogonadism and morbid obesity. 9 38
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199
Endocrine secretions under abnormal light-dark cycles and in the blind. 9 38
9550117 1998
200
[Disorders of gonadal function in hypothalamic-pituitary diseases]. 9 38
9396297 1997
201
Short stature and failure of pubertal development in thalassaemia major: evidence for hypothalamic neurosecretory dysfunction of growth hormone secretion and defective pituitary gonadotropin secretion. 9 38
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202
Effects of leuprolide-induced hypogonadism and testosterone replacement on sleep, melatonin, and prolactin secretion in men. 9 38
9329339 1997
203
Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene. 9 38
9271483 1997
204
Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. 9 38
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Subcutaneous self-administration of highly purified follicle stimulating hormone and human chorionic gonadotrophin for the treatment of male hypogonadotrophic hypogonadism. Spanish Collaborative Group on Male Hypogonadotropic Hypogonadism. 9 38
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A functional determinant in human luteinizing hormone and chorionic gonadotropin: differential effect of mutations about beta-GLN-54. 9 38
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Adult-onset idiopathic hypogonadotropic hypogonadism--a treatable form of male infertility. 9 38
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The pituitary-gonadal axis and health in elderly men: a study of men born in 1913. 9 38
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[Endocrinologic problems of the male adolescent]. 9 38
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Autoimmune polyglandular syndrome and primary biliary cirrhosis. 9 38
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Testosterone-induced increase of insulin-like growth factor I levels depends upon normal levels of growth hormone. 9 38
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212
Endocrine screening for sexual dysfunction using free testosterone determinations. 9 38
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213
Serum levels of insulin-like growth factor I and insulin-like growth factor-binding protein 1 correlate with serum free testosterone and sex hormone binding globulin levels in healthy young and middle-aged men. 9 38
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Severe ovarian hyperstimulation syndrome despite low plasma oestrogen concentrations in a hypogonadotrophic, hypogonadal patient. 9 38
8671418 1996
215
Neuroendocrine mechanisms mediating awakening of the human gonadotropic axis in puberty. 9 38
8792395 1996
216
A family with an unusual myotonic and myopathic phenotype and no CTG expansion (proximal myotonic myopathy syndrome): a challenge for future molecular studies. 9 38
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Evidence for the Bauman variant in Kallmann's syndrome. 9 38
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[Delayed puberty and hypogonadotrophic hypogonadism: differential diagnosis with prolactin stimulation probe with chlorpromazine]. 9 38
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219
Alcoholic hypogonadism: hormonal response to clomiphene. 9 38
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220
Evaluation of human chorionic gonadotropin stimulation tests in prepubertal and early pubertal boys. 9 38
8582400 1995
221
Primary hypogonadism in females with infantile onset spinocerebellar ataxia. 9 38
8552218 1995
222
Identification of a putative steroidogenic factor-1 response element in the DAX-1 promoter. 9 38
7677767 1995
223
Isolated combined growth hormone and gonadotrophin deficiency due to hypothalamic dysfunction, associated with insulin resistance. 9 38
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224
Variable penetrance of hypogonadism in a sibship with Kallmann syndrome due to a deletion of the KAL gene. 9 38
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Turner's syndrome and hypogonadotrophic hypogonadism: thalassemia major and hemochromatosis. 9 38
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Hormonal substitution in older men. 9 38
7721255 1995
227
Changes in anterior pituitary response in patients with idiopathic hypothalamic hypogonadism caused by pulsatile GnRH therapy and testosterone replacement. 9 38
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228
Hormonal therapy of male hypogonadism. 9 38
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Parathyroid hormone for the prevention of bone loss induced by estrogen deficiency. 9 38
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[Endocrinological problems in male adolescents]. 9 38
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Diurnal rhythm of testosterone induced by human chorionic gonadotrophin (hCG) therapy in isolated hypogonadotrophic hypogonadism: a comparison between subcutaneous and intramuscular hCG administration. 9 38
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232
Gonadal function and response to human chorionic and menopausal gonadotrophin therapy in male patients with idiopathic hypogonadotrophic hypogonadism. 9 38
7914153 1994
233
Gene deletion causing adrenal hypoplasia congenita and hypogonadotrophic hypogonadism. 9 38
8033374 1994
234
Male hypogonadism in myotonic dystrophy is related to (CTG)n triplet mutation. 9 38
8077624 1994
235
Hyposomatomedinemia and hypogonadism in hemiplegic men who live in nursing homes. 9 38
8185456 1994
236
Endogenous opioids and hypogonadism in human obesity. 9 38
7922600 1994
237
Isolation and characterization of the gene responsible for the X chromosome-linked Kallmann syndrome. 9 38
7999985 1994
238
The direct pituitary effect of testosterone to inhibit gonadotropin secretion in men is partially mediated by aromatization to estradiol. 9 38
8188534 1994
239
Pulsatile administration of gonadotrophin releasing hormone as a diagnostic tool to distinguish hypothalamic from pituitary hypogonadism following neurosurgery. 9 38
8276962 1993
240
Pulsatile gonadotrophin releasing hormone versus gonadotrophin treatment of hypothalamic hypogonadism in males. 9 38
8276954 1993
241
Pulsatile GnRH treatment in boys and girls with idiopathic hypogonadotrophic hypogonadism. 9 38
8276956 1993
242
Environment, human reproduction, menopause, and andropause. 9 38
8243411 1993
243
Anterior pituitary function after adrenalectomy in patients with Cushing's syndrome. 9 38
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244
Familial insulin resistant diabetes associated with acanthosis nigricans, polycystic ovaries, hypogonadism, pigmentary retinopathy, labyrinthine deafness, and mental retardation. 9 38
8456839 1993
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Regional obesity and NIDDM. 9 38
8249691 1993
246
[Heterogeneity of immunoreactive prolactin in hyperprolactinemia of various origin]. 9 38
1302839 1992
247
Excessive L-thyroxine therapy decreases femoral bone mineral densities in the male rat: effect of hypogonadism and calcitonin. 9 38
1456090 1992
248
Risk of osteoporosis in men with chronic bronchitis. 9 38
1392267 1992
249
Physiologic testosterone levels in normal men suppress high-density lipoprotein cholesterol levels. 9 38
1586105 1992
250
The role of treatment with growth hormone in infertile patients. 9 38
1424324 1992
251
Progressive high frequency hearing loss: an additional feature in the syndrome of congenital adrenal hypoplasia and gonadotrophin deficiency. 9 38
1601004 1992
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Circadian rhythm of plasma testosterone in men with idiopathic hypogonadotrophic hypogonadism before and during pulsatile administration of gonadotrophin-releasing hormone. 9 38
1559297 1992
253
Pathophysiology of cancer: hormonal and metabolic abnormalities. 9 38
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254
Comparison of gonadotropin-releasing hormone and gonadotropin therapy in male patients with idiopathic hypothalamic hypogonadism. 9 38
1743335 1991
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Subcutaneous gonadotropin therapy in male patients with hypogonadotropic hypogonadism. 9 38
1906410 1991
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Simultaneous occurrence of SIADH, secondary hypogonadism and alopecia universalis in a woman with IDDM. 9 38
1666359 1991
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Cushing's disease and hyperprolactinemia due to a mixed ACTH- and prolactin-secreting pituitary macroadenoma. 9 38
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[Metabolic cirrhosis (hemochromatosis, Wilson's disease, erythropoietic protoporphyria)]. 9 38
2063117 1991
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Migratory arrest of gonadotropin-releasing hormone neurons in transgenic mice. 9 38
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260
Hypogonadism of male prolactinomas: relation to pulsatile secretion of LH. 9 38
2099670 1990
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Sex hormone binding globulin: origin, function and clinical significance. 9 38
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Induction of ovulation with pulsatile GnRH. 9 38
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Congenital cerebellar hypoplasia and hypogonadotropic hypogonadism. 9 38
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[The effect of acute ACTH1-24 loading on the steroid hormone and prolactin content of the blood serum in women with hyperprolactinemia and hyperandrogenism]. 9 38
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[Pulsatile administration of gonadotropin releasing hormone in the female. Diagnostic and therapeutic indications]. 9 38
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Serum inhibin concentrations before and during gonadotropin treatment in men with hypogonadotropic hypogonadism: physiological and clinical implications. 9 38
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Investigation and management of subfertility. 38
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Impact of genetic subtypes of Prader-Willi syndrome with growth hormone therapy on intelligence and body mass index. 38
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Neural Crest Cell Failure as Embryogenesis for Fusiform Aneurysm of the Anterior Communicating Artery: Case Report and Review of the Literature. 38
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Ciliochoroidal effusion syndrome with central serous-like chorioretinopathy and secondary angle closure following exogenous testosterone use. 38
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Melatonin appears to protect against steroidogenic collapse in both mice fed with high-fat diet and H2 O2 -treated TM3 cells. 38
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Gonadal hormone-dependent vs. -independent effects of kisspeptin signaling in the control of body weight and metabolic homeostasis. 38
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Exome Sequencing of a Primary Ovarian Insufficiency Cohort Reveals Common Molecular Etiologies for a Spectrum of Disease. 38
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Addressing gaps in care of people with conditions affecting sex development and maturation. 38
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Laboratory evaluation of secondary causes of bone loss in Veterans with spinal cord injury and disorders. 38
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31392573 2019
305
Autoimmune phenomena involving the pituitary gland in children: New developing data about diagnosis and treatment. 38
31401342 2019
306
A 10-year longitudinal study of evaluation of ovarian reserve in women with transfusion-dependent beta thalassaemia major. 38
31082742 2019
307
Oocyte quality in women with thalassaemia major: insights from IVF cycles. 38
31404374 2019
308
Combined Pituitary Hormone Deficiency Caused by a Synonymous HESX1 Gene Mutation. 38
30888394 2019
309
Identification of ROBO1/2 and SCEL as candidate genes in Kallmann syndrome with emerging bioinformatic analysis. 38
31325086 2019
310
45,X/46,X,i(Yp): Importance of Assessment and Support during Puberty and Adolescence. 38
31266049 2019
311
Kisspeptin recombinant oral vaccine: A master gene vaccine inhibiting the reproductive physiology and behavior of ram lambs. 38
29097006 2019
312
Testosterone undecanoate supplementation together with human chorionic gonadotropin does not impair spermatogenesis in males with isolated hypogonadotropic hypogonadism: a retrospective study. 38
30604694 2019
313
Woodhouse-Sakati Syndrome: First report of a Portuguese case. 38
31347785 2019
314
Pheochromocytoma, paragangliomas, and pituitary adenoma: An unusual association in a patient with an SDHD mutation. Case report. 38
31348302 2019
315
Possibility of early diagnosis in a fetus affected by Prader‑Willi syndrome with maternal hetero‑UPD15: A lesson to be learned. 38
31115529 2019
316
Challenges in the Diagnosis of Medulloblastoma Recurrence at an Unusual Site in a Patient With Prader-Willi Syndrome. 38
31306337 2019
317
Association of bifid epiglottis and laryngeal web with Bardet-Biedl syndrome: A case report. 38
31022684 2019
318
Prader-Willi Syndrome - Clinical Genetics, Diagnosis and Treatment Approaches: An Update. 38
31333129 2019
319
Male hypogonadism: 14-year prospective outcome in 550 men with type 2 diabetes. 38
31294081 2019
320
Dietary vs. pharmacological doses of zinc: A clinical review. 38
31303527 2019
321
Monitoring testosterone replacement therapy with transdermal gel: when and how? 38
31267510 2019
322
CRISPR/dCas9-mediated activation of multiple endogenous target genes directly converts human foreskin fibroblasts into Leydig-like cells. 38
31264792 2019
323
Pubertal and Adult Testicular Functions in Nonclassic Lipoid Congenital Adrenal Hyperplasia: A Case Series and Review. 38
31286101 2019
324
46,XX Testicular Disorder of Sex Development (DSD): A Case Report and Systematic Review. 38
31336995 2019
325
Replacement of Male Mini-Puberty. 38
31240270 2019
326
Genotypic and phenotypic spectra of hemojuvelin mutations in primary hemochromatosis patients: a systematic review. 38
31286966 2019
327
Testicular ultrasound inhomogeneity is an informative parameter for fertility evaluation. 38
31274478 2019
328
An industry update in therapeutics: what is the latest news? 38
31232184 2019
329
Ovotesticular Disorder of Sex Development: A Rare Case of Lateral Subtype 45X/46XY kariotype Diagnosed in Adulthood. 38
31005658 2019
330
Why Do Normal Children Have Acromegalic Levels of IGF-I During Puberty? 38
30840065 2019
331
Effects of Bariatric Surgery in Male Obesity-Associated Hypogonadism. 38
31065918 2019
332
Severe hypoglycemia and hyponatremia caused by hypopituitarism in a female patient with type 1 diabetes: A case report. 38
31305453 2019
333
Lack of Improvement of Sperm Characteristics in Obese Males After Obesity Surgery Despite the Beneficial Changes Observed in Reproductive Hormones. 38
30806913 2019
334
Perrault syndrome with amenorrhea, infertility, Tarlov cyst, and degenerative disc. 38
31274036 2019
335
Defective AMH signaling disrupts GnRH neuron development and function and contributes to hypogonadotropic hypogonadism. 38
31291191 2019
336
Isolated Hypogonadotropic Hypogonadism Secondary to Anti-Programmed Death Ligand 1 Inhibitor. 38
31235040 2019
337
Pituitary magnetic resonance imaging abnormalities in young female patients with hypogonadotropic hypogonadism. 38
31338342 2019
338
RF9: May it be a new therapeutic option for hypogonadotropic hypogonadism? 38
31203909 2019
339
Reversible male hypogonadotropic hypogonadism due to energy deficit. 38
30903626 2019
340
S100a4-Cre-mediated deletion of Patched1 causes hypogonadotropic hypogonadism: role of pituitary hematopoietic cells in endocrine regulation. 38
31265437 2019
341
Contribution of Liver Fat to Weight Loss-Induced Changes in Serum Hepatokines: A Randomized Controlled Trial. 38
30753672 2019
342
[Reflexions on 50 Years of Sexual Medicine in Urology Focusing on Male Sexual Dysfunctions]. 38
31342492 2019
343
Symptoms of sexual dysfunction among men from infertile couples: prevalence and association with testosterone deficiency. 38
31325248 2019
344
Androgen deficiency in older men. 38
31256511 2019
345
Late-onset hypogonadism (LOH), masculinity and relationship and sexual satisfaction: are sexual symptoms of LOH mediators of traditional masculinity on relationship and sexual satisfaction? 38
31287968 2019
346
Human Chorionic Gonadotropin monotherapy for the treatment of hypogonadal symptoms in men with total testosterone > 300 ng/dL. 38
31408289 2019
347
ENDOCRINOLOGY AND ADOLESCENCE: Dealing with transition in young patients with pituitary disorders. 38
31370006 2019
348
Growth hormone secretion, fatigue and quality of life after childhood traumatic brain injury. 38
31319378 2019
349
Bone Densitometry in Transgender and Gender Nonconforming (TGNC) Individuals: The 2019 ISCD Official Positions. 38
31327665 2019
350
Mayer-Rokitansky-Küster-Hauser syndrome with a uterine cervix and normal vagina associated with gonadal dysgenesis in a 46,XX female. 38
30912224 2019
351
Adjuvant carboplatin therapy in patients with clinical stage 1 testicular seminoma: is long-term morbidity increased? 38
31286241 2019
352
Comparison of Anthropometric Measures for Evaluating the Association Between Hypogonadism and Hypothalamic-Pituitary-Gonadal Hormones in a Taiwanese Population. 38
31084407 2019
353
Effects of SHBG rs1799941 Polymorphism on Free Testosterone Levels and Hypogonadism Risk in Young Non-Diabetic Obese Males. 38
31370189 2019
354
Neuropsychiatric and Behavioral Involvement in AAS Abusers. A Literature Review. 38
31336641 2019
355
Metabolic Effects of Testosterone Therapy in Men with Type 2 Diabetes and Metabolic Syndrome. 38
30803918 2019
356
Insulin-like factor 3, luteinizing hormone and testosterone in testicular cancer patients: effects of β-hCG and cancer treatment. 38
30609309 2019
357
Klinefelter Syndrome and Diabetes. 38
31367971 2019
358
The impact of childhood cancer and its treatment on puberty and subsequent hypothalamic pituitary and gonadal function, in both boys and girls. 38
31327697 2019
359
Measuring testosterone in women and men. 38
31133215 2019
360
Chronic high-dose testosterone treatment: impact on rat cardiac contractile biology. 38
31353833 2019
361
Leydig cell failure with testicular radiation doses <20Gy: The clinical effects of total body irradiation conditioned haematopoietic stem cell transplantation for childhood leukaemia during long-term follow-up. 38
31295360 2019
362
Oncological safety of testosterone replacement therapy in prostate cancer survivors after definitive local therapy: A systematic literature review and meta-analysis. 38
31296421 2019
363
Acute myeloid leukaemia presenting with diabetes insipidus. 38
31185522 2019
364
Insights into the molecular regulatory network of pathomechanisms in osteochondroma. 38
31211456 2019
365
Re: Trends in Testosterone Prescribing for Age-Related Hypogonadism in Men with and without Heart Disease. 38
30888894 2019
366
An analysis of online content related to testosterone supplementation. 38
29921150 2019
367
Improvements in semen parameters in men treated with clomiphene citrate-A retrospective analysis. 38
30779195 2019
368
Extensive Phenotyping for Potential Weight-Inducing Factors in an Outpatient Population with Obesity. 38
31216558 2019
369
A comprehensive diagnostic approach to detect underlying causes of obesity in adults. 38
30821060 2019
370
Prader- Willi syndrome: An uptodate on endocrine and metabolic complications. 38
31065942 2019
371
Testosterone levels in men with chronic migraine. 38
31281602 2019
372
Deletion of the Homeodomain Protein Six6 from GnRH Neurons Decreases GnRH Gene Expression Resulting in Infertility. 38
31211355 2019
373
Nonstop mutation in the Kisspeptin 1 receptor (KISS1R) gene causes normosmic congenital hypogonadotropic hypogonadism. 38
31073722 2019
374
Prospective evaluation of hypogonadism in male metastatic renal cell carcinoma patients treated with targeted therapies. 38
29774795 2019
375
Chronic tyrosine kinase inhibitor (TKI) use in metastatic renal cell carcinoma (mRCC): can this lead to the adverse effect of hypogonadism? 38
30995130 2019
376
Severe Fanconi Anemia phenotypes in Fancd2 depletion mice. 38
31078270 2019
377
A case of premature ovarian insufficiency in Nijmegen breakage syndrome patient and review of literature. From gene mutation to clinical management. 38
31187634 2019
378
BBS5 and INPP5E mutations associated with ciliopathy disorders in families from Pakistan. 38
31173343 2019
379
The changing burden of long-term health outcomes in survivors of childhood acute lymphoblastic leukaemia: a retrospective analysis of the St Jude Lifetime Cohort Study. 38
31078468 2019
380
Association between duration of obesity and severity of ovarian dysfunction in rat-cafeteria diet approach. 38
31349120 2019
381
Detailed retinal phenotype of Boucher-Neuhäuser syndrome associated with mutations in PNPLA6 mimicking choroideremia. 38
31135245 2019
382
Isolated hypoaldosteronism as first sign of X-linked adrenal hypoplasia congenita caused by a novel mutation in NR0B1/DAX-1 gene: a case report. 38
31164167 2019
383
Germ cell arrest associated with aSETX mutation in ataxia oculomotor apraxia type 2. 38
30642639 2019
384
[Manifestation of Graves' disease, resulting from radiosurgical treatment of acromegaly, in a patient with panhypopituitarism]. 38
31271712 2019
385
Prevalence and Course of Endocrinopathy in POEMS Syndrome. 38
30239770 2019
386
Functional analysis of SOX10 mutations identified in Chinese patients with Kallmann syndrome. 38
30914325 2019
387
Testosterone levels after treatment with urofollitropin in infertile patients with idiopathic mild reduction of testicular volume. 38
31240459 2019
388
Prevalence of endocrine disorders and their associated factors in transfusion-dependent thalassemia patients: a historical cohort study in Southern Iran. 38
31228105 2019
389
PITUITARY IMAGING BY MRI AND ITS CORRELATION WITH BIOCHEMICAL PARAMETERS IN THE EVALUATION OF MEN WITH HYPOGONADOTROPIC HYPOGONADISM. 38
31170366 2019
390
Characteristic dynamics of height and weight in preschool boys with constitutional delay of growth and puberty or hypogonadotropic hypogonadism. 38
31211864 2019
391
NAFLD in Some Common Endocrine Diseases: Prevalence, Pathophysiology, and Principles of Diagnosis and Management. 38
31212642 2019
392
Effect of Testosterone on FGF2, MRF4, and Myostatin in Hypogonadotropic Hypogonadism: Relevance to Muscle Growth. 38
30629183 2019
393
A rare case in literature: Isochromosome Xq in Klinefelter syndrome. 38
30746732 2019
394
Undiagnosed prediabetes is highly prevalent in primary infertile men - results from a cross-sectional study. 38
30328251 2019
395
Turner syndrome: mechanisms and management. 38
31213699 2019
396
Indications and outcomes of varicocele repair. 38
30990285 2019
397
Pituitary pathology in traumatic brain injury: a review. 38
30927184 2019
398
Risk factors for hypogonadism in young men with erectile dysfunction. 38
30932936 2019
399
A toddler with a novel LEPR mutation. 38
30778850 2019
400
A critical assessment of case reports describing absent uterus in subjects with oestrogen deficiency. 38
30820975 2019
401
Are hypothyroidism and hypogonadism clinically relevant in patients with malignant gliomas? A longitudinal trial in patients with glioma. 38
30712840 2019
402
Current stepwise recommendations for hypogonadism screening in erectile dysfunction are not cost-effective. 38
31243352 2019
403
Trends in erectile dysfunction research from 2008 to 2018: a bibliometric analysis. 38
31235897 2019
404
Long-Term Safety and Efficacy of Clomiphene Citrate for the Treatment of Hypogonadism. 38
31216250 2019
405
Testosterone Therapy in Men With Hypogonadism Prevents Progression From Prediabetes to Type 2 Diabetes: Eight-Year Data From a Registry Study. 38
30862651 2019
406
[Prevalence of anabolic androgenic steroid use, its effect on the male pituitary-gonadal axis, and the possibility of reproductive rehabilitation]. 38
31271715 2019
407
Longitudinal changes in bone density in adolescents and young adults with cerebral palsy: A case for early intervention. 38
31246317 2019
408
Early puberty in end stage renal failure and renal transplant recipients. 38
31141486 2019
409
Mutation profile of BBS genes in patients with Bardet-Biedl syndrome: an Italian study. 38
31196119 2019
410
Benefits and risks of testosterone therapy in older men. 38
30700083 2019
411
ENDOCRINE HISTORY: The history of discovery, synthesis and development of testosterone for clinical use. 38
30959485 2019
412
Effect of treatment with testosterone on endothelial function in hypogonadal men: a systematic review and meta-analysis. 38
31235898 2019
413
Adverse events during testosterone replacement therapy in 95 young hypogonadal thalassemic men. 38
31125000 2019
414
Luteinizing hormone signaling is involved in synchronization of Leydig cell's clock and is crucial for rhythm robustness of testosterone production†. 38
30722003 2019
415
Defective DNA Polymerase α-Primase Leads to X-Linked Intellectual Disability Associated with Severe Growth Retardation, Microcephaly, and Hypogonadism. 38
31006512 2019
416
Adverse Health Outcomes in Relationship to Hypogonadism After Chemotherapy: A Multicenter Study of Testicular Cancer Survivors. 38
31085753 2019
417
Pathogenesis of Thalassemia Major-associated Osteoporosis: A Review with Insights from Clinical Experience 38
29991466 2019
418
Small cell lung cancer with panhypopituitarism due to ectopic adrenocorticotropic hormone syndrome: A case report. 38
31183350 2019
419
Testosterone Replacement Therapy and the Risk of Prostate Cancer in Men with Late-Onset Hypogonadism. 38
31145457 2019
420
Enclomiphene citrate: A treatment that maintains fertility in men with secondary hypogonadism. 38
31063005 2019
421
MECHANISMS IN ENDOCRINOLOGY: Estradiol as a male hormone. 38
31096185 2019
422
Obesity and Hypogonadism-A Narrative Review Highlighting the Need for High-Quality Data in Adolescents. 38
31052376 2019
423
Substance Abuse and Male Hypogonadism. 38
31121993 2019
424
Paediatric and adult-onset male hypogonadism. 38
31147553 2019
425
Paediatric and adult-onset male hypogonadism. 38
31147556 2019
426
Clinical and genetic analysis in males with 46,XX disorders of sex development: A reproductive centre experience of 144 cases. 38
30623467 2019
427
Treatment of gonadotropin deficiency during the first year of life: long-term observation and outcome in five boys. 38
31067328 2019
428
Mechanism and chain-specificity of RNF216/TRIAD3, the ubiquitin ligase mutated in Gordon-Holmes Syndrome. 38
31087003 2019
429
[A four-generation pedigree affected with X-linked adrenal hypoplasia congenita due to a novel missense DAX1 mutation]. 38
31030432 2019
430
Growth hormone deficiency and neurocognitive function in adult survivors of childhood acute lymphoblastic leukemia. 38
30690723 2019
431
Comparing the role of anti-Müllerian hormone as a marker of FSH action in male and female fertility. 38
30880521 2019
432
Prostate Cancer, Gender Identity, and Testosterone Replacement Therapy in Klinefelter Syndrome: A Case Report and Literature Review. 38
31312556 2019
433
The association between body mass index and testosterone deficiency in aging Chinese men with benign prostatic hyperplasia: results from a cross-sectional study. 38
31058560 2019
434
Evaluation of gonadotropin-replacement therapy in male patients with hypogonadotropic hypogonadism. 38
31062720 2019
435
Testosterone replacement in congenital hypogonadotropic hypogonadism maintains bone density but has only limited osteoanabolic effects. 38
30851011 2019
436
Screening for mutations in selected miRNA genes in hypogonadotropic hypogonadism patients. 38
30999277 2019
437
Familial GATA6 mutation causing variably expressed diabetes mellitus and cardiac and renal abnormalities. 38
31051468 2019
438
A Clinical Perspective of Sleep and Andrological Health: Assessment, Treatment Considerations and Future Research. 38
31042277 2019
439
Tribulus terrestris versus placebo in the treatment of erectile dysfunction and lower urinary tract symptoms in patients with late-onset hypogonadism: A placebo-controlled study. 38
30253697 2019
440
High rates of ovarian function preservation after hematopoietic cell transplantation with melphalan-based reduced intensity conditioning for pediatric acute leukemia: an analysis from the Japan Association of Childhood Leukemia Study (JACLS). 38
30864117 2019
441
Metabolic Syndrome Is an Independent Risk Factor for Acquired Premature Ejaculation. 38
30588783 2019
442
Testosterone Replacement Therapy for Patients with Hypogonadism after High Dose-Rate Brachytherapy for High-Risk Prostate Cancer: A Report of Six Cases and Literature Review. 38
31081296 2019
443
Experimental hypogonadism: insulin resistance, biochemical changes and effect of testosterone substitution. 38
31054251 2019
444
Review of Hormone Replacement Therapy in Girls and Adolescents with Hypogonadism. 38
31059821 2019
445
Re: Clomiphene Citrate and Human Chorionic Gonadotropin are Both Effective in Restoring Testosterone in Hypogonadism: A Short-Course Randomized Study. 38
30747887 2019
446
A new compound heterozygous mutation in a female with 17α-hydroxylase/17,20-lyase deficiency, slipped capital femoral epiphysis, and adrenal myelolipoma. 38
30614301 2019
447
Endocrine implications of bariatric surgery: a review on the intersection between incretins, bone, and sex hormones. 38
31134746 2019
448
The PROK2/PROKR2 signaling pathway is required for the migration of most olfactory bulb interneurons. 38
31132148 2019
449
Low testosterone is associated with frailty, muscle wasting and physical dysfunction among men receiving hemodialysis: a longitudinal analysis. 38
30085235 2019
450
Increasing hypothalamic nucleobindin 2 levels and decreasing hypothalamic inflammation in obese male mice via diet and exercise alleviate obesity-associated hypogonadism. 38
30503692 2019
451
Clomiphene Citrate for the Treatment of Hypogonadism. 38
30522888 2019
452
Male infertility in renal failure and transplantation. 38
31080778 2019
453
An update on heart disease risk associated with testosterone boosting medications. 38
30998433 2019
454
Hyperprolactinemia associated with macroprolactinoma in a 17-year-old: A case report. 38
31016137 2019
455
Jaundice and anaemia as presenting features of an incomplete autoimmune polyglandular syndrome type II. 38
30962212 2019
456
Testosterone Profiles After Brachytherapy for Localized Prostate Cancer. 38
30716344 2019
457
DIAGNOSIS OF ENDOCRINE DISEASE: Evaluation of bone fragility in endocrine disorders. 38
31042675 2019
458
Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective. 38
30550360 2019
459
Duplication of 10q24 locus: broadening the clinical and radiological spectrum. 38
30622331 2019
460
The ability of an LC-MS/MS-based erythrocyte GALT enzyme assay to predict the phenotype in subjects with GALT deficiency. 38
30718057 2019
461
Testosterone and Benign Prostatic Hyperplasia. 38
30803920 2019
462
How much does obesity affect the male reproductive function? 38
31391924 2019
463
Observational study of clinical outcomes for testosterone treatment of pubertal delay in Duchenne muscular dystrophy. 38
31023296 2019
464
Impact of pituitary dysfunction on cognitive and global outcome after traumatic brain injury and aneurysmal subarachnoid haemorrhage. 38
30761404 2019
465
A New Case of PCSK1 Pathogenic Variant With Congenital Proprotein Convertase 1/3 Deficiency and Literature Review. 38
30383237 2019
466
The Health Threat Posed by the Hidden Epidemic of Anabolic Steroid Use and Body Image Disorders Among Young Men. 38
30239802 2019
467
Clinical Management of Congenital Hypogonadotropic Hypogonadism. 38
30698671 2019
468
Relationships between eating disorder psychopathology, sexual hormones and sexual behaviours. 38
31026479 2019
469
The prevalence of low serum free testosterone and the short-term effect of anti-retroviral therapy in male Japanese treatment-naïve HIV patients. 38
30292767 2019
470
Vitamin D, bone mineral density and risk of fracture in people with intellectual disabilities. 38
30569589 2019
471
Cardiovascular and Cerebrovascular Safety of Testosterone Replacement Therapy Among Aging Men with Low Testosterone Levels: A Cohort Study. 38
30953635 2019
472
Changes in total sperm count after gastric bypass and sleeve gastrectomy: the BARIASPERM prospective study. 38
31147284 2019
473
Association of total and calculated free testosterone with androgen deficiency symptoms in patients with type 2 diabetes. 38
31000814 2019
474
Trends in Testosterone Prescribing for Age-related Hypogonadism in Men With and Without Heart Disease. 38
30592484 2019
475
Ablating astrocyte insulin receptors leads to delayed puberty and hypogonadism in mice. 38
30893295 2019
476
Pituitary-testicular Axis Dysfunction in Methimazole-induced Hypothyroidism in Rats. 38
30989148 2019
477
AMH and INSL3 in testicular and extragonadal pathophysiology: what do we know? 38
30793542 2019
478
Sertoli Cell Function in Young Males with Metabolic Syndrome. 38
31161113 2019
479
Cryptozoospermia after treatment with clomiphene citrate following long-term use of intramuscular testosterone undecanoate depot injection (Nebido®). 38
30870141 2019
480
Bardet-Biedl syndrome: Antenatal presentation of forty-five fetuses with biallelic pathogenic variants in known Bardet-Biedl syndrome genes. 38
30614526 2019
481
Regulation of anti-Müllerian hormone (AMH) in males and the associations of serum AMH with the disorders of male fertility. 38
30381580 2019
482
Abaloparatide, a novel osteoanabolic PTHrP analog, increases cortical and trabecular bone mass and architecture in orchiectomized rats by increasing bone formation without increasing bone resorption. 38
30343166 2019
483
Endocrine Manifestations in POEMS Syndrome: a case report and literature review. 38
30902082 2019
484
Nivolumab-induced hypophysitis leading to hypopituitarism and secondary empty sella syndrome in a patient with non-small cell lung cancer. 38
30850565 2019
485
PROKR2 mutations in idiopathic hypogonadotropic hypogonadism: selective disruption of the binding to a Gα-protein leads to biased signaling. 38
30576231 2019
486
Three Siblings with Idiopathic Hypogonadotropic Hypogonadism in a Nonconsanguineous Family: A Novel KISS1R/GPR54 Loss-of-Function Mutation 38
30905142 2019
487
Thyroid function in Klinefelter syndrome: a multicentre study from KING group. 38
30912057 2019
488
Nonalcoholic Fatty Liver Disease, Male Sexual Dysfunction, and Infertility: Common Links, Common Problems. 38
30898592 2019
489
Klinefelter Syndrome: Clinical Spectrum Based on 44 Consecutive Cases from a South Indian Tertiary Care Center. 38
31161115 2019
490
Gordon Holmes syndrome due to compound heterozygosity of two new PNPLA6 variants - A diagnostic challenge. 38
30555943 2019
491
Differentiation of human induced pluripotent stem cells into Leydig-like cells with molecular compounds. 38
30833541 2019
492
Vitamin D3 supplementation improves testicular function in diabetic rats through peroxisome proliferator-activated receptor-γ/transforming growth factor-beta 1/nuclear factor-kappa B. 38
29953732 2019
493
Risk of Erythrocytosis During Concomitant Testosterone and SGLT2-Inhibitor Treatment: A Warning From Two Clinical Cases. 38
30395251 2019
494
Primary amenorrhoea secondary to two different syndromes: a case study. 38
30878957 2019
495
Re: Effects of Clomiphene Citrate on Male Obesity-Associated Hypogonadism: . 38
30759646 2019
496
Effects of liraglutide on obesity-associated functional hypogonadism in men. 38
30707677 2019
497
Osteoprotective Effects of Tribulus terrestris L.: Relationship Between Dehydroepiandrosterone Levels and Ca2+-Sparing Effect. 38
30888914 2019
498
Prevalence of Low Bone Density and Comorbid Hypogonadism in Patients With Chronic Pancreatitis. 38
30768576 2019
499
[Monitoring of the treatment of hypogonadotropic hypogonadism in the infant]. 38
29891229 2019
500
Management of ovulation induction and intrauterine insemination in infertile patients with hypogonadotropic hypogonadism. 38
30930300 2019
501
Physical activity counteracts metabolic syndrome-induced hypogonadotropic hypogonadism and erectile dysfunction in the rabbit. 38
30645174 2019
502
Renal Damaging Effect Elicited by Bicalutamide Therapy Uncovered Multiple Action Mechanisms As Evidenced by the Cell Model. 38
30833616 2019
503
Sexual Dysfunction in Men with Prediabetes. 38
30852183 2019
504
Prospective Study on Sexual Dysfunction in Male Chinese Liver Transplant Recipients. 38
30836839 2019
505
Cardiometabolic health in Turner syndrome. 38
30775849 2019
506
Sex hormone replacement therapy for individuals with Turner syndrome. 38
30809949 2019
507
Clinical Characteristics and Postoperative Recovery of Hypopituitarism in Patients with Nonfunctional Pituitary Adenoma. 38
30880207 2019
508
Quality of life and chronic health conditions in childhood acute leukaemia survivors. 38
30017209 2019
509
Xyosted--a testosterone auto-injector for hypogonadism. 38
30845097 2019
510
Clarifying the link between ibuprofen and hypogonadism. 38
30664744 2019
511
Management of Anabolic Steroid-Induced Infertility: Novel Strategies for Fertility Maintenance and Recovery. 38
30929329 2019
512
Late-onset Hypogonadism and Testosterone Therapy - A Summary of Guidelines from the American Urological Association and the European Association of Urology. 38
30858073 2019
513
Testosterone replacement therapy is associated with an increased risk of urolithiasis. 38
30903351 2019
514
Long-term testosterone therapy in type 2 diabetes is associated with reduced mortality without improvement in conventional cardiovascular risk factors. 38
30216622 2019
515
Successful in vitro maturation of oocytes in a woman with gonadotropin-resistant ovary syndrome associated with a novel combination of FSH receptor gene variants: a case report. 38
30610662 2019
516
A 52-Week Study of Dose Adjusted Subcutaneous Testosterone Enanthate in Oil Self-Administered via Disposable Auto-Injector. 38
30296416 2019
517
Bone accrual in oligo-amenorrheic athletes, eumenorrheic athletes and non-athletes. 38
29758361 2019
518
Delayed hypopituitarism following Russell's viper envenomation: a case series and literature review. 38
30317419 2019
519
Glu2.53(90) of the GnRH receptor is part of the conserved G protein-coupled receptor structure and does not form a salt-bridge with Lys3.32(121). 38
30476558 2019
520
Role of Relative Malnutrition in Exercise Hypogonadal Male Condition. 38
30212398 2019
521
Dopamine agonist-responsive Cushing's disease. 38
30765454 2019
522
Endocrine and metabolic complications in children and adolescents with Sickle Cell Disease: an Italian cohort study. 38
30744584 2019
523
High frequency of CHD7 mutations in congenital hypogonadotropic hypogonadism. 38
30733481 2019
524
Prevalence and associated phenotypes of PLXNA1 variants in normosmic and anosmic idiopathic hypogonadotropic hypogonadism. 38
30467832 2019
525
Thyroid function in patients with Prader-Willi syndrome: an Italian multicenter study of 339 patients. 38
30703060 2019
526
MY-T study: Symptom-based titration decisions when using testosterone nasal gel, Natesto®. 38
31364978 2019
527
Implementation of a Pilot Pharmacist Testosterone Therapy Management Service. 38
30791810 2019
528
The protective effects of Crocin on testopathy in fat-fed and streptozotocin-treated diabetic rats: An experimental study. 38
31435592 2019
529
Use of medicinal doses of zinc as a safe and efficient coadjutant in the treatment of male hypogonadism. 38
30767598 2019
530
Endocrine complications of celiac disease: a case report and review of the literature. 38
30198791 2019
531
Bifocal germinoma in a patient with 16p11.2 microdeletion syndrome. 38
30738016 2019
532
Rarity of Laurence Moon Bardet Biedl Syndrome and its Poor Management in the Pakistani Population. 38
31058008 2019
533
[Implication in Paediatrics of the First International Consensus Statement for the Diagnosis and management of pseudohypoparathyroidism and related disorders]. 38
30591400 2019
534
[Infertility Due to Hyperprolactinemia in Empty Sella : A Case Report]. 38
31067844 2019
535
Galactocele of adult male breast: A cytopathologist's perspective. 38
30461216 2019
536
Long-term treatment with testosterone undecanoate injections in men with hypogonadism alleviates erectile dysfunction and reduces risk of major adverse cardiovascular events, prostate cancer, and mortality. 38
30782054 2019
537
Hypogonadism in Men With Hepatitis C: What Is a Clinician to Do? 38
30715228 2019
538
Endocrine aspects of Klinefelter syndrome. 38
30507702 2019
539
Medical Treatments for Hypogonadism do not Significantly Increase the Risk of Deep Vein Thrombosis Over General Population Risk. 38
30447269 2019
540
The Optimal Indication for Testosterone Replacement Therapy in Late Onset Hypogonadism. 38
30736442 2019
541
An Internet-Based Survey to Assess Clinicians' Knowledge and Attitudes Towards Opioid-Induced Hypogonadism. 38
30269435 2019
542
The My-T study: Patient satisfaction and preference comparing topical and nasal testosterone therapies. 38
30817284 2019
543
Exploring the spectrum of late effects following radical orchidectomy for stage I testicular seminoma: a systematic review of the literature. 38
30350189 2019
544
Can the positive association of osteocalcin with testosterone be unmasked when the preeminent hypothalamic-pituitary regulation of testosterone production is impaired? The model of spinal cord injury. 38
29729005 2019
545
Aggressiveness of Localized Prostate Cancer: the Key Value of Testosterone Deficiency Evaluated by Both Total and Bioavailable Testosterone: AndroCan Study Results. 38
30293206 2019
546
Sexual Identity Disorder and Psychosis in Klinefelter Syndrome: A Synthesis of Literature and a Case Report. 38
30672880 2019
547
Similarities and differences in the reproductive phenotypes of women with congenital hypogonadotrophic hypogonadism caused by GNRHR mutations and women with polycystic ovary syndrome. 38
30476149 2019
548
Sex hormones, obesity and type 2 diabetes: is there a link? 38
30533003 2019
549
Association Between Extra-Genital Congenital Anomalies and Hypospadias Outcome. 38
30913557 2019
550
The experience of a tertiary unit on the clinical phenotype and management of hypogonadism in female adolescents and young adults with transfusion dependent thalassemia. 38
30889170 2019
551
The Genetic Basis of Delayed Puberty. 38
31293522 2019
552
Hypothalamic-Pituitary-Ovarian Axis Disorders Impacting Female Fertility. 38
30621143 2019
553
Kisspeptin and its Effect on Mammalian Spermatogensis. 38
29380696 2019
554
Novel DNA variation of GPR54 gene in familial central precocious puberty. 38
30635063 2019
555
TET1 regulates fibroblast growth factor 8 transcription in gonadotropin releasing hormone neurons. 38
31361780 2019
556
GnRH-1 Neural Migration From the Nose to the Brain Is Independent From Slit2, Robo3 and NELL2 Signaling. 38
30881290 2019
557
Clinical Use of FSH in Male Infertility. 38
31178827 2019
558
Functional and Phenotypic Characteristics of Human Leptin Receptor Mutations. 38
30560226 2019
559
The influence of the rs1137101 genotypes of leptin receptor gene on the demographic and metabolic profile of normal Saudi females and those suffering from polycystic ovarian syndrome. 38
30635060 2019
560
Endocrine and Metabolic Outcomes After Transcranial and Endoscopic Endonasal Approaches for Primary Resection of Craniopharyngiomas. 38
30266691 2019
561
Case series of infertility amongst young women with perinatally acquired HIV: data from a London cohort. 38
30800426 2019
562
Genetics of ncHH: from a peculiar inheritance of a novel GNRHR mutation to a comprehensive review of the literature. 38
30575316 2019
563
WDR11 is another causative gene for coloboma, cardiac anomaly and growth retardation in 10q26 deletion syndrome. 38
30711679 2019
564
Neuropsychiatric Aspects in Men with Klinefelter Syndrome. 38
29972105 2019
565
Evidence for long noncoding RNA GAS5 up-regulationin patients with Klinefelter syndrome. 38
30612561 2019
566
The combination of acromegaly and Klinefelter syndrome in one patient. 38
30823838 2019
567
The Pulsatile Gonadorelin Pump Induces Earlier Spermatogenesis Than Cyclical Gonadotropin Therapy in Congenital Hypogonadotropic Hypogonadism Men. 38
30569789 2019
568
Type 1 Diabetes Mellitus and Klinefelter Syndrome. 38
30146555 2019
569
Hormone Replacement Therapy in Cancer Survivors - Review of the Literature. 38
30617760 2019
570
Gonadal function and testicular histology in males with Prader-Willi syndrome. 38
30815576 2019
571
Bone Health in Patients With Liver Diseases. 38
30744928 2019
572
Identification and Characterization of Known Biallelic Mutations in the IFT27 (BBS19) Gene in a Novel Family With Bardet-Biedl Syndrome. 38
30761183 2019
573
A novel compound heterozygous mutation in TTC8 identified in a Japanese patient. 38
30886724 2019
574
Clinical, Histochemical, and Molecular Study of Three Turkish Siblings Diagnosed with H Syndrome, and Literature Review. 38
30625464 2019
575
Testosterone, testosterone therapy and prostate cancer. 38
30614347 2019
576
Prokineticins and their G protein-coupled receptors in health and disease. 38
30711026 2019
577
RNF216 Regulates the Migration of Immortalized GnRH Neurons by Suppressing Beclin1-Mediated Autophagy. 38
30733708 2019
578
Nivolumab-induced thyroid dysfunction in patients with lung cancer. 38
29910159 2019
579
Testicular Preservation in 46 XY Denys-Drash Syndrome: A Report of Two Cases. 38
29975959 2019
580
Two cases of male patients followed for a classical form of congenital adrenal hyperplasia (CAH), presenting an azoospermia: analysis and review of the literature. 38
31143447 2019
581
Causes Of Primary Amenorrhea At Tertiary Level Hospital. 38
30868785 2019
582
Postnatal Testicular Activity in Healthy Boys and Boys With Cryptorchidism. 38
31396156 2019
583
Identification and Functional Analysis of Six DAX1 Mutations in Patients With X-Linked Adrenal Hypoplasia Congenita. 38
30620004 2019
584
Juvenile hemochromatosis with multi-organ involvement diagnosed at autopsy. 38
30583831 2019
585
Clinical manifestations, evaluation and management of hyperprolactinemia in adolescent and young girls: a brief review. 38
30889169 2019
586
Pitfalls in the Diagnostic Evaluation of Hyperprolactinemia. 38
30889571 2019
587
Hypogonadism and Sexual Dysfunction in Testicular Tumor Survivors: A Systematic Review. 38
31133982 2019
588
Clomiphene for hypogonadism complicated by polycythemia. 38
30956589 2019
589
Clinical practice update on testosterone therapy for male hypogonadism: Contrasting perspectives to optimize care. 38
30358898 2019
590
The effects of testosterone replacement therapy on the prostate: a clinical perspective. 38
30828436 2019
591
Loss of Enzyme Activity in Mutated B4GALNT1 Gene Products in Patients with Hereditary Spastic Paraplegia Results in Relatively Mild Neurological Disorders: Similarity with Phenotypes of B4galnt1 Knockout Mice. 38
30521973 2019
592
Ginsenoside Rg3 protects mouse leydig cells against triptolide by downregulation of miR-26a. 38
31296984 2019
593
Werner's Syndrome: Understanding the Phenotype of Premature Aging-First Case Described in Colombia. 38
30891318 2019
594
A Follow-Up from Infancy to Puberty in a Japanese Male with SRY-Negative 46,XX Testicular Disorder of Sex Development Carrying a p.Arg92Trp Mutation in NR5A1. 38
30739115 2019
595
Osteogenesis Imperfecta Due to Combined Heterozygous Mutations in Both COL1A1 and COL1A2, Coexisting With Pituitary Stalk Interruption Syndrome. 38
30984112 2019
596
Elevated Body Mass Index Is Associated with Secondary Hypogonadism Among Men Presenting to a Tertiary Academic Medical Center. 38
30350484 2019
597
Final Height and Endocrine Complications in Patients with β-Thalassemia Intermedia: Our Experience in Non-Transfused Versus Infrequently Transfused Patients and Correlations with Liver Iron Content. 38
31205630 2019
598
Remission of type 2 diabetes and pleiotropic effects of long-term testosterone treatment for "late-onset" hypogonadism: A case report. 38
30719309 2019
599
Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications. 38
30503797 2019
600
Androgen Deficiency and Phosphodiesterase Type 5 Expression Changes in Aging Male: Therapeutic Implications. 38
31110491 2019
601
Correlation between serum P450arom and sex hormones in males with late-onset hypogonadism: a pilot study. 38
30657548 2019
602
The paradox of marrow adipose tissue in anorexia nervosa. 38
29458121 2019
603
Glucose Abnormalities Associated to Prolactin Secreting Pituitary Adenomas. 38
31191454 2019
604
Are hypothyroidism and hypogonadism clinically relevant in patients with malignant gliomas? A longitudinal trial in patients with glioma. 38
30389240 2019
605
Corrigendum: Hypogonadism and Sexual Dysfunction in Testicular Tumor Survivors: A Systematic Review. 38
31258516 2019
606
Investigating the basis of sexual dysfunction during late-onset hypogonadism. 38
30984376 2019
607
[Relation between sexual dysfunction and metabolic syndrome]. 38
30640528 2019
608
Obstructive Sleep Apnea and Testosterone Deficiency. 38
29774669 2019
609
Patients presenting to a Men's Health clinic are at higher risk for depression, insomnia, and sleep apnea. 38
30171191 2019
610
Long-Term Follow Up of the Erectile Function of Testicular Cancer Survivors. 38
31001201 2019
611
Investigation of treatment for azoospermia due to male hypogonadotropic hypogonadism in Japan. 38
30302833 2019
612
Metabolic Disorders and Male Hypogonadotropic Hypogonadism. 38
31402895 2019
613
Psychological Aspects of Congenital Hypogonadotropic Hypogonadism. 38
31333578 2019
614
Whole Exome Sequencing Revealed a Novel Nonsense Variant in the GNRHR Gene Causing Normosmic Hypogonadotropic Hypogonadism in a Pakistani Family. 38
30947225 2019
615
Evidence for a Common Genetic Origin of Classic and Milder Adult-Onset Forms of Isolated Hypogonadotropic Hypogonadism. 38
30669598 2019
616
Gonadotropin replacement in male thalassemia major patients with arrested puberty and acquired hypogonadotropic hypogonadism (AAH): preliminary results and potential factors affecting induction of spermatogenesis. 38
30298384 2019
617
Managing congenital hypogonadotrophic hypogonadism: a contemporary approach directed at optimizing fertility and long-term outcomes in males. 38
30800268 2019
618
Testosterone Is a Contraceptive and Should Not Be Used in Men Who Desire Fertility. 38
30350483 2019
619
Late-Onset Hypogonadism as Primary Testicular Failure. 38
31244778 2019
620
Congenital Hypogonadotrophic Hypogonadism: Minipuberty and the Case for Neonatal Diagnosis. 38
30846970 2019
621
Re: Testosterone Therapy in Men with Hypogonadism: An Endocrine Society Clinical Practice Guideline. 38
30577344 2019
622
Age Induced Nitroso-Redox Imbalance Leads to Subclinical Hypogonadism in Male Mice. 38
30984111 2019
623
A study on hypogonadism in male HIV patients in northeastern part of India. 38
31143855 2019
624
Hypogonadism in Children with a Previous History of Cancer: Endocrine Management and Follow-Up. 38
30703774 2019
625
Rutin ameliorates carbon tetrachloride (CCl4)-induced hepatorenal toxicity and hypogonadism in male rats. 38
31179192 2019
626
Effect of Korean Herbal Formula (Modified Ojayeonjonghwan) on Androgen Receptor Expression in an Aging Rat Model of Late Onset Hypogonadism. 38
30584994 2019
627
The severity of hypogonadism symptoms and its risk factors among male employees of Tehran University of Medical Sciences. 38
30651006 2019
628
Important lessons about testosterone therapy- weight loss vs. testosterone therapy for symptom resolution, classical vs. functional hypogonadism, and shortterm vs. lifelong testosterone therapy. 38
30651008 2019
629
[Reproductive disorders and preservation of fertility in males with benign and malignant brain tumors]. 38
31166318 2019
630
Association of low testosterone with changes in non-cardiovascular biomarkers in adult men. 38
30670838 2019
631
Testosterone replacement therapy and the risk of adverse cardiovascular outcomes and mortality. 38
30976419 2019
632
Type 2 Diabetes and Testosterone Therapy. 38
30079639 2019
633
Nasal Placode Development, GnRH Neuronal Migration and Kallmann Syndrome. 38
31355196 2019
634
Impact of Sleep Deprivation on the Hypothalamic-Pituitary-Gonadal Axis and Erectile Tissue. 38
30621925 2019
635
A new genetic variant of hereditary apolipoprotein A-I amyloidosis: a case-report followed by discussion of diagnostic challenges and therapeutic options. 38
30665372 2019
636
Opioid-mediated Sertoli cells apoptosis is involved in testicular homeostasis and/or reproductive dysfunction. 38
31023050 2019
637
Review: The role of zinc in the endocrine system. 38
30772815 2019
638
Vitamin D3 Activates Phosphatidylinositol-3-Kinase/Protein Kinase B via Insulin-Like Growth Factor-1 to Improve Testicular Function in Diabetic Rats. 38
31281852 2019
639
[Venous thromboembolism and urological cancer: Epidemiology and therapeutically management]. 38
30316671 2019
640
Complete Kisspeptin Receptor Inactivation Does Not Impede Exogenous GnRH-Induced LH Surge in Humans. 38
30124894 2018
641
Iron overload directly affecting the ovaries in a patient with Diamond-Blackfan anaemia: a case report. 38
28643569 2018
642
Brain MR Imaging Findings in Woodhouse-Sakati Syndrome. 38
30409855 2018
643
Gonadotropin- and Adrenocorticotropic Hormone-Independent Precocious Puberty of Gonadal Origin in a Patient with Adrenal Hypoplasia Congenita Due to DAX1 Gene Mutation - A Case Report and Review of the Literature: Implications for the Pathomechanism. 38
30537713 2018
644
Novel CNS malformations and skeletal anomalies in a patient with Beaulieu-boycott-Innes syndrome. 38
30238602 2018
645
Adverse effects of doping with anabolic androgenic steroids in competitive athletics, recreational sports and bodybuilding. 38
29463075 2018
646
Bi-allelic POLR3A Loss-of-Function Variants Cause Autosomal-Recessive Wiedemann-Rautenstrauch Syndrome. 38
30414627 2018
647
The role of ADAMTS4 and ADAMTS9 in cardiovascular disease in premature ovarian insufficiency and idiopathic hypogonadotropic hypogonadism. 38
30187439 2018
648
Special form of osteoporosis in a 53-year-old man. 38
30567240 2018
649
Noonan syndrome males display Sertoli cell-specific primary testicular insufficiency. 38
30325180 2018
650
Metastatic Prostate Cancer in a RAD51C Mutation Carrier. 38
30587560 2018
651
[Prostate Cancer Diagnosed during Androgen Replacement Therapy for Late-Onset Hypogonadism Treatment: A Case Report]. 38
30831666 2018
652
Hypogonadotropic hypogonadism and pituitary hypoplasia as recurrent features in Ulnar-Mammary syndrome. 38
30550377 2018
653
Ghrelin Receptor Agonist Rescues Excess Neonatal Mortality in a Prader-Willi Syndrome Mouse Model. 38
30380028 2018
654
Noncytotoxic-Related Primary Ovarian Insufficiency in Adolescents: Multicenter Case Series and Review. 38
29940314 2018
655
A homozygous G insertion in MPLKIP leads to TTDN1 with the hypergonadotropic hypogonadism symptom. 38
30598092 2018
656
Fertility induction in hypogonadotropic hypogonadal men. 38
30194850 2018
657
[Hypophysitis and retroperitoneal fibrosis associated with autoimmune polyglandular syndrome and IgG4-related disease. Report of one case]. 38
30848754 2018
658
The association of cardiorespiratory fitness, body mass index, and age with testosterone levels at screening of healthy men undergoing preventive medical examinations: The Cooper Center Longitudinal Study. 38
30415749 2018
659
Recombinant Human FSH Treatment Outcomes in Five Boys With Severe Congenital Hypogonadotropic Hypogonadism. 38
30519672 2018
660
Möbius syndrome associated with obesity and precocious puberty. 38
30567196 2018
661
A novel de novo frameshift mutation in NR0B1 and low prenatal estriol in adrenal hypoplasia congenita. 38
30129976 2018
662
Premature ovarian failure. 38
30650978 2018
663
Testicular morphology in hypogonadotropic hypogonadism after the abuse of anabolic steroids. 38
30175397 2018
664
Testosterone deficiency in non-cancer opioid-treated patients. 38
30343356 2018
665
Hypothalamic and pituitary dysfunction is common in tubercular meningitis: A prospective study from a tertiary care center in Northern India. 38
30321796 2018
666
Fertility and infertility: Definition and epidemiology. 38
29555319 2018
667
Prolactinomas: how to handle prior to and during pregnancy? 38
29265784 2018
668
Bone management in hematologic stem cell transplant recipients. 38
30178158 2018
669
Invasive pituitary adenomas with gross total resection: The wait-and-see policy during postoperative management. 38
30454695 2018
670
PITUITARY EVALUATION IN PATIENTS WITH LOW PROSTATE-SPECIFIC ANTIGEN. 38
30289304 2018
671
Structural modeling and mRNA expression of epididymal β-defensins in GnRH immunized boars: A model for secondary hypogonadism in man. 38
30307666 2018
672
A novel GNRHR gene mutation causing congenital hypogonadotrophic hypogonadism in a Brazilian kindred. 38
30415482 2018
673
Histomorphological changes in the common carotid artery of the male rat in induced hypogonadism. 38
30637163 2018
674
Testosterone therapy and venous thromboembolism: A systematic review and meta-analysis. 38
30396049 2018
675
Ibuprofen does not have an adverse impact on semen parameters. 38
30328572 2018
676
[Andrology in oncological diseases]. 38
30353297 2018
677
Obesity-related cellular stressors regulate gonadotropin releasing hormone gene expression via c-Fos/AP-1. 38
30063946 2018
678
Iron as a Therapeutic Target in HFE-Related Hemochromatosis: Usual and Novel Aspects. 38
30486249 2018
679
[Clinical and genetic features of Kallmann syndrome: an analysis of 5 cases]. 38
30477624 2018
680
Assessing Sex Steroid Influence on Kisspeptin Responsiveness in Idiopathic Hypogonadotropic Hypogonadism. 38
30430143 2018
681
[Hemochromatosis related Arthropathy]. 38
30468115 2018
682
Secondary male hypogonadism: A prevalent but overlooked comorbidity of obesity. 38
29974886 2018
683
Body composition changes with testosterone replacement therapy following spinal cord injury and aging: A mini review. 38
28770686 2018
684
Treating exercise-associated low testosterone and its related symptoms. 38
30063407 2018
685
Assisted reproductive techniques with congenital hypogonadotropic hypogonadism patients: a systematic review and meta-analysis. 38
30453944 2018
686
Xanthomatous hypophysitis causing hypogonadotropic hypogonadism resulting in delayed presentation of slipped capital femoral epiphysis. 38
30450996 2018
687
Evaluation of testicular function in prepubertal children. 38
29982874 2018
688
Testosterone-Associated Dietary Pattern Predicts Low Testosterone Levels and Hypogonadism. 38
30453566 2018
689
Depression in Nonclassical Hypogonadism in Young Men. 38
30430144 2018
690
The influence of metabolic profile of obese men on the severity of erectile dysfunction: are metabolically healthy obese individuals protected? 38
30201077 2018
691
Clomiphene citrate and human chorionic gonadotropin are both effective in restoring testosterone in hypogonadism: a short-course randomized study. 38
29772111 2018
692
Short-term effects of surgical weight loss after sleeve gastrectomy on sex steroids plasma levels and PSA concentration in men with severe obesity. 38
30449231 2018
693
Hypogonadal men with moderate-to-severe lower urinary tract symptoms have a more severe cardiometabolic risk profile and benefit more from testosterone therapy than men with mild lower urinary tract symptoms. 38
30402573 2018
694
Long-term follow-up of gonadal dysfunction in morbidly obese adolescent boys after bariatric surgery. 38
30352040 2018
695
Human in vivo metabolism study of LGD-4033. 38
30255601 2018
696
Sport, doping and male fertility. 38
30415644 2018
697
Intramuscular Testosterone Supplementation Ameliorates Depression in Hypogonadal Men: A Retrospective Study in an Outpatient Department. 38
29390199 2018
698
Klinefelter Syndrome. The Effects of Early Androgen Therapy on Competence and Behavioral Phenotype. 38
29680294 2018
699
[The 46,XX male; a chromosomal form of a disorder of sex development]. 38
30358369 2018
700
Male infertility problems of patients with strict sperm morphology between 5-14% may be missed with the current WHO guidelines. 38
30602328 2018
701
Clinical utility of endocrine markers predicting myocardial siderosis in transfusion dependent thalassemia major. 38
29893484 2018
702
Potential application of testosterone replacement therapy as treatment for obesity and type 2 diabetes in men. 38
30118780 2018
703
Skeletal Consequences of Nephropathic Cystinosis. 38
29905968 2018
704
Clinical relevance of low androgen to gastroesophageal reflux symptoms. 38
30068893 2018
705
Understanding the functions of kisspeptin and kisspeptin receptor (Kiss1R) from clinical case studies. 38
30339828 2018
706
Burden Testing of Rare Variants Identified through Exome Sequencing via Publicly Available Control Data. 38
30269813 2018
707
A rare variety of congenital adrenal hyperplasia with mosaic Klinefelter syndrome: a unique combination presenting with ambiguous genitalia and sexual precocity 38
30328339 2018
708
Downregulation of leptin receptor and kisspeptin/GPR54 in the murine hypothalamus contributes to male hypogonadism caused by high-fat diet-induced obesity. 38
29948931 2018
709
Hypogonadism is independently associated with varicocele repair in a contemporary cohort of men in the USA. 38
30381578 2018
710
Use of testosterone in men infected with human immunodeficiency virus in the veterans healthcare system. 38
29557189 2018
711
Aging-related compensated hypogonadism: Role of metabolomic analysis in physiopathological and therapeutic evaluation. 38
29920416 2018
712
THE RARE CASE OF MIXED GONADAL DYSGENESIS, MOSAIC KARYOTYPE, PETROCLIVAL MENINGIOMA AND IDIOPATHIC HYPERDEHYDROEPIANDROSTERONISM. 38
31149308 2018
713
A Search for Disorders of Sex Development among Infertile Men. 38
30372699 2018
714
Case of newly diagnosed bilateral anorchia in a 42-year-old male patient. 38
30317195 2018
715
Statin medications and the risk of gynecomastia. 38
29923212 2018
716
Management Strategies in Opioid Abuse and Sexual Dysfunction: A Review of Opioid-Induced Androgen Deficiency. 38
30057139 2018
717
Symptomatic androgen deficiency develops only when both total and free testosterone decline in obese men who may have incident biochemical secondary hypogonadism: Prospective results from the EMAS. 38
29855071 2018
718
The gonadotropin system, lessons from animal models and clinical cases. 38
30264954 2018
719
Metabolic Profile of Patients with Premature Ovarian Insufficiency. 38
30347864 2018
720
Extrapontine Myelinolysis and Reversible Parkinsonism After Hyponatremia Correction in a Case of Pituitary Adenoma: Hypopituitarism as a Predisposition for Osmotic Demyelination. 38
30055367 2018
721
Hiding in a plain sight: A high prevalence of androgen deficiency due to primary hypogonadism among acute medical inpatients with anaemia. 38
29992620 2018
722
Prevalence and treatment of central hypogonadism and hypoandrogenism in women with hypopituitarism. 38
29789996 2018
723
Clinical outcomes in male patients with lactotroph adenomas who required pituitary surgery: a retrospective single center study. 38
29936681 2018
724
Increased risk of reproductive dysfunction in women prescribed long-term opioids for musculoskeletal pain: A matched cohort study in the Clinical Practice Research Datalink. 38
29873872 2018
725
Establishing normal values of total testosterone in adult healthy men by the use of four immunometric methods and liquid chromatography-mass spectrometry. 38
29746252 2018
726
Variable workup calls for guideline development for type 2A hereditary haemochromatosis. 38
30362946 2018
727
MECHANISMS OF ENDOCRINOLOGY: Endocrinology of opioids 38
30299887 2018
728
A Case of Familial Male-Limited Precocious Puberty in a Child With Klinefelter Syndrome. 38
30283825 2018
729
Is there a difference in phenotype between males and females with non-transfusion-dependent thalassemia? A cross-sectional evaluation. 38
29303050 2018
730
The hypothalamus-pituitary-gonad axis: Tales of mice and men. 38
29223677 2018
731
HS6ST1 Insufficiency Causes Self-Limited Delayed Puberty in Contrast With Other GnRH Deficiency Genes. 38
29931354 2018
732
Gonadotropin-releasing hormone (GnRH) deficiency under treatment: psychological and sexual functioning impacts. 38
30168087 2018
733
Severe iodine deficiency from dietary restriction and subsequent iodine excess from seaweed snack overuse in an adolescent with disordered eating. 38
30189113 2018
734
The frequencies of Y chromosome microdeletions in infertile males. 38
29799410 2018
735
Klinefelter syndrome: more than hypogonadism. 38
29382506 2018
736
Natural history and clinical characteristics of 50 patients with Wolfram syndrome. 38
29728875 2018
737
Incomplete methylation of a germ cell tumor (Seminoma) in a Prader-Willi male. 38
30003711 2018
738
Kallmann syndrome: phenotype and genotype of hypogonadotropic hypogonadism. 38
29108899 2018
739
Targeted Gene Panel Sequencing for Molecular Diagnosis of Kallmann Syndrome and Normosmic Idiopathic Hypogonadotropic Hypogonadism. 38
30216942 2018
740
[Hormone Replacement Therapy in Males]. 38
30231287 2018
741
Interleukin 6 inhibits the differentiation of rat stem Leydig cells. 38
29180110 2018
742
Male Central Hypogonadism in Paediatrics - the Relevance of Follicle-stimulating Hormone and Sertoli Cell Markers. 38
30349597 2018
743
Testosterone replacement therapy: For whom, when and how? 38
29530796 2018
744
The complex association between metabolic syndrome and male hypogonadism. 38
29656047 2018
745
Testicular microlithiasis in a boy with X-linked adrenal hypoplasia congenita. 38
30286574 2018
746
Effects of combined growth hormone and testosterone treatments in a rat model of micropenis. 38
30352406 2018
747
Intermediate and long-term complications associated with adjuvant chemotherapy for stage I germ cell tumor patients. 38
30044319 2018
748
The Tip of the Iceberg in Maternally Inherited Diabetes and Deafness. 38
30210725 2018
749
Assessment of Pituitary Gonadal Axis and Sperm Parameters in Anemic Eugonadal Males Before and After Correction of Iron Deficiency Anemia. 38
31321929 2018
750
NASH in Nondiabetic Endocrine Disorders. 38
29873585 2018
751
IL-1 Antagonism in Men With Metabolic Syndrome and Low Testosterone: A Randomized Clinical Trial. 38
29939279 2018
752
Chronic estradiol exposure – harmful effects on behavior, cardiovascular and reproductive functions 38
30328341 2018
753
[Stimulation of spermatogenesis in men with hypogonadotropic hypogonadism]. 38
30240383 2018
754
Rare case of meningococcal sepsis-induced testicular failure, primary hypothyroidism and hypoadrenalism: Is there a link? 38
30219775 2018
755
Best practice in the diagnosis and treatment of varicocele in children and adolescents. 38
30116303 2018
756
Male and Female Hypogonadism. 38
30100005 2018
757
Cardiovascular impact of testosterone therapy for hypogonadism. 38
30099911 2018
758
The CATCH checklist to investigate adult-onset hypogonadism. 38
29888533 2018
759
Re: Ibuprofen Alters Human Testicular Physiology To Produce a State of Compensated Hypogonadism. 38
29680733 2018
760
Retro- and orthonasal olfactory function in relation to olfactory bulb volume in patients with hypogonadotrophic hypogonadism. 38
28870428 2018
761
Improved Lower Urinary Tract Symptoms Associated With Testosterone Replacement Therapy in Japanese Men With Late-Onset Hypogonadism. 38
27256990 2018
762
Androgen Receptor CAG Repeat Length as a Risk Factor of Late-Onset Hypogonadism in a Korean Male Population. 38
29706560 2018
763
Nasal delivery of nerve growth factor rescue hypogonadism by up-regulating GnRH and testosterone in aging male mice. 38
30131307 2018
764
Analysis of the association of EPHB6, EFNB1 and EFNB3 variants with hypertension risks in males with hypogonadism. 38
30262919 2018
765
Lycium chinense Mill improves hypogonadism via anti-oxidative stress and anti-apoptotic effect in old aged rat model. 38
30269620 2018
766
The efficacy and safety of short-acting testosterone ointment (Glowmin) for late-onset hypogonadism in accordance with testosterone circadian rhythm. 38
29734846 2018
767
Influence of testosterone substitution on glycemic control and endothelial markers in men with newly diagnosed functional hypogonadism and type 2 diabetes mellitus: a randomized controlled trial. 38
30235049 2018
768
Effect of Dose and 5α-Reductase Inhibition on the Circulating Testosterone Metabolite Profile of Men Administered Oral Testosterone. 38
29877607 2018
769
Two cases of Cushing's syndrome due to primary bilateral macronodular adrenal hyperplasia secondary to aberrant adrenal expression of hormone receptors. 38
29936051 2018
770
Efficacy of Testosterone Treatment in Hemodialysis Patients as Assessed by Aging Males' Symptoms Scores: A Pilot Study. 38
29720027 2018
771
Tramadol (opioid) abuse is associated with a dose- and time-dependent poor sperm quality and hyperprolactinaemia in young men. 38
29781510 2018
772
Effects of zinc deficiency on impaired spermatogenesis and male infertility: the role of oxidative stress, inflammation and apoptosis. 38
30129823 2018
773
Potential role of gender specific effect of leptin receptor deficiency in an extended consanguineous family with severe early-onset obesity. 38
29545012 2018
774
Diversity of Pubertal Development in Cartilage-Hair Hypoplasia; Two Illustrative Cases. 38
29462708 2018
775
Deficiency in GnRH receptor trafficking due to a novel homozygous mutation causes idiopathic hypogonadotropic hypogonadism in three prepubertal siblings. 38
29777911 2018
776
[Diagnosis and treatment of idiopathic hypogonadotropic hypogonadism in males]. 38
30173437 2018
777
Management of hypogonadism from birth to adolescence. 38
30086863 2018
778
Klinefelter's syndrome with lupus encephalitis and retroperitoneal teratoma. 38
29759049 2018
779
H syndrome: Clinical, histological and genetic investigation in Tunisian patients. 38
29808591 2018
780
Rhinencephalon changes in tuberous sclerosis complex. 38
29909560 2018
781
Generation of induced pluripotent stem cells, KCi001-A derived from a Bardet-Biedl syndrome patient compound heterozygous for the BBS1 variants c.1169T>G/c.1135G>C. 38
30142598 2018
782
Evaluating CHARGE syndrome in congenital hypogonadotropic hypogonadism patients harboring CHD7 variants. 38
29144511 2018
783
Rare cause of manic period trigger in bipolar mood disorder: testosterone replacement. 38
30076163 2018
784
Endocrinological aspects of HIV infection. 38
29313284 2018
785
Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement. 38
29959430 2018
786
Mutation profiles and clinical characteristics of Chinese males with isolated hypogonadotropic hypogonadism. 38
30098700 2018
787
MRI of ectopic posterior pituitary gland with dysgenesis of pituitary stalk in a patient with hypogonadotropic hypogonadism. 38
29887929 2018
788
Evaluation of Sexual Function in Women with Hypogonadotropic Hypogonadism Using the Female Sexual Function Index (FSFI) and the Beck Depression Inventory (BDI). 38
30099473 2018
789
Risk factors for late-onset hypogonadism. 38
29665142 2018
790
Spurious testosterone laboratory results in a patient taking synthetic alkaline phosphatase (asfotase alfa). 38
29709501 2018
791
Absenteeism and Indirect Economic Burden Associated With Primary and Secondary Hypogonadism: A Retrospective Matched Cohort Analysis of Employed, Commercially Insured Patients in the U.S. 38
29634610 2018
792
Sleeve Gastrectomy Reversed Obesity-Induced Hypogonadism in a Rat Model by Regulating Inflammatory Responses in the Hypothalamus and Testis. 38
29508270 2018
793
Testosterone treatment in older men: clinical implications and unresolved questions from the Testosterone Trials. 38
30017800 2018
794
Klinefelter syndrome, insulin resistance, metabolic syndrome, and diabetes: review of literature and clinical perspectives. 38
29572708 2018
795
Klinefelter Syndrome: Integrating Genetics, Neuropsychology, and Endocrinology. 38
29438472 2018
796
Neuro-radiological features can predict hypopituitarism in primary autoimmune hypophysitis. 38
29752700 2018
797
Estradiol Does Not Influence Lipid Measures and Inflammatory Markers in Testosterone-Clamped Healthy Men. 38
30057969 2018
798
Role of androgens for urethral homeostasis. 38
30211042 2018
799
Three new Brazilian cases of 17α-hydroxylase deficiency: clinical, molecular, hormonal, and treatment features. 38
29982238 2018
800
Reoperation for growth hormone-secreting pituitary adenomas: report on an endonasal endoscopic series with a systematic review and meta-analysis of the literature. 38
28862548 2018
801
Frontiers in hormone therapy for male infertility. 38
30159242 2018
802
An exceptional presentation of pituicytoma apoplexy: A case report. 38
29928451 2018
803
Late effects after hematopoietic stem cell transplantation for β-thalassemia major: the French national experience. 38
29599204 2018
804
A novel PNPLA6 compound heterozygous mutation identified in a Chinese patient with Boucher‑Neuhäuser syndrome. 38
29749493 2018
805
Low-dose gonadotropin induction of ovulation in anovulatory women: still needed in the age of IVF. 38
29459401 2018
806
Endocrine, Sexual Function, and Infertility Side Effects of Immune Checkpoint Inhibitor Therapy for Genitourinary Cancers. 38
29971696 2018
807
The effect of iron chelation therapy on overall survival in sickle cell disease and β-thalassemia: A systematic review. 38
29635754 2018
808
JAK/STAT signaling pathway gene expression is reduced following Nelf knockdown in GnRH neurons. 38
29050862 2018
809
Probabilistic cost-effectiveness analysis of controlled ovarian stimulation with recombinant FSH plus recombinant LH vs. human menopausal gonadotropin for women undergoing IVF. 38
30021630 2018
810
Comprehensive Endocrine-Metabolic Evaluation of Patients With Alström Syndrome Compared With BMI-Matched Controls. 38
29718281 2018
811
Cardiomyopathy induced by anabolic-androgenic steroid abuse. 38
30037963 2018
812
PRADER-WILLI SYNDROME: WHAT IS THE GENERAL PEDIATRICIAN SUPPOSED TO DO? - A REVIEW. 38
30365815 2018
813
Surgical Outcomes of Plaque Excision and Grafting and Supplemental Tunica Albuginea Plication for Treatment of Peyronie's Disease With Severe Compound Curvature. 38
29802005 2018
814
Dysregulation of the RANKL/RANK/OPG axis in thalassemia intermedia patients. 38
30064480 2018
815
Glucocorticoid-induced osteoporosis: an update. 38
29691807 2018
816
Identification of A Novel Compound Heterozygous Mutation in BBS12 in An Iranian Family with Bardet-Biedl Syndrome Using Targeted Next Generation Sequencing. 38
29633607 2018
817
Leukodystrophy with disorders of sex development due to WT1 mutations. 38
29801916 2018
818
Phenotypic analysis of hemochromatosis subtypes reveals variations in severity of iron overload and clinical disease. 38
29743178 2018
819
The Relationship Between Shift Work and Men's Health. 38
29371140 2018
820
Possible mechanisms underlying fatty liver in a rat model of male hypogonadism: A protective role for testosterone. 38