MCID: HYP064
MIFTS: 40

Hypogonadotropism

Categories: Endocrine diseases

Aliases & Classifications for Hypogonadotropism

MalaCards integrated aliases for Hypogonadotropism:

Name: Hypogonadotropism 12 55 15
Hypogonadism 73

Classifications:



External Ids:

Disease Ontology 12 DOID:7455

Summaries for Hypogonadotropism

MalaCards based summary : Hypogonadotropism, also known as hypogonadism, is related to hypogonadotropic hypogonadism 7 with or without anosmia and hypogonadotropic hypogonadism 23 without anosmia. An important gene associated with Hypogonadotropism is PRL (Prolactin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Hormone ligand-binding receptors. The drugs Zinc and Dihydrotachysterol have been mentioned in the context of this disorder. Affiliated tissues include bone, prostate and testes, and related phenotypes are endocrine/exocrine gland and digestive/alimentary

Related Diseases for Hypogonadotropism

Diseases related to Hypogonadotropism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 hypogonadotropic hypogonadism 7 with or without anosmia 33.3 GNRH1 GNRHR
2 hypogonadotropic hypogonadism 23 without anosmia 32.9 GNRH1 GNRHR
3 hypogonadotropic hypogonadism 30.9 GNRH1 GNRHR KISS1 KISS1R
4 normosmic congenital hypogonadotropic hypogonadism 30.6 GNRH1 GNRHR KISS1 KISS1R
5 kallmann syndrome 30.6 GNRH1 GNRHR KISS1 KISS1R
6 amenorrhea 30.0 GNRH1 PRL
7 hypothalamic disease 29.8 GNRH1 PRL
8 empty sella syndrome 29.8 GNRH1 PRL
9 hyperprolactinemia 29.8 GNRH1 PRL
10 anovulation 29.7 GNRH1 PRL
11 craniopharyngioma 29.5 GNRH1 PRL
12 hypopituitarism 29.4 GNRH1 PRL
13 premature ovarian failure 1 29.2 GNRH1 PRL
14 hypogonadism 29.2 GNRH1 GNRHR KISS1 KISS1R
15 precocious puberty 29.1 GNRH1 KISS1 KISS1R
16 ovarian disease 29.0 GNRH1 PRL
17 central precocious puberty 28.7 GNRH1 KISS1 KISS1R
18 hypogonadotropic hypogonadism 12 with or without anosmia 12.3
19 hypogonadotropic hypogonadism 1 with or without anosmia 12.3
20 hypogonadotropic hypogonadism 10 with or without anosmia 12.3
21 hypogonadotropic hypogonadism 21 with or without anosmia 12.3
22 hypogonadotropic hypogonadism 8 with or without anosmia 12.3
23 hypogonadotropic hypogonadism 11 with or without anosmia 12.3
24 hypogonadotropic hypogonadism 13 with or without anosmia 12.3
25 hypogonadotropic hypogonadism 15 with or without anosmia 12.3
26 hypogonadotropic hypogonadism 16 with or without anosmia 12.3
27 hypogonadotropic hypogonadism 20 with or without anosmia 12.3
28 hypogonadotropic hypogonadism 9 with or without anosmia 12.2
29 hypogonadotropic hypogonadism 14 with or without anosmia 12.2
30 hypogonadotropic hypogonadism 17 with or without anosmia 12.2
31 hypogonadotropic hypogonadism 19 with or without anosmia 12.2
32 hypogonadotropic hypogonadism 22 with or without anosmia 12.2
33 hypogonadotropic hypogonadism 3 with or without anosmia 12.2
34 hypogonadotropic hypogonadism 5 with or without anosmia 12.2
35 hypogonadotropic hypogonadism 18 with or without anosmia 12.2
36 hypogonadotropic hypogonadism 4 with or without anosmia 12.2
37 hypogonadotropic hypogonadism 6 with or without anosmia 12.2
38 hypogonadotropic hypogonadism 2 with or without anosmia 12.2
39 leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism 12.2
40 leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism 12.2
41 hypogonadotropic hypogonadism 24 without anosmia 12.1
42 gordon holmes syndrome 11.9
43 adrenal hypoplasia, congenital 11.8
44 hypogonadotropic hypogonadism-severe microcephaly-sensorineural hearing loss-dysmorphism syndrome 11.8
45 multicore myopathy with mental retardation, short stature, and hypogonadotropic hypogonadism 11.7
46 hypogonadotropic hypogonadism without anosmia, x-linked 11.7
47 hypogonadotropic hypogonadism-frontoparietal alopecia syndrome 11.7
48 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 11.7
49 moebius syndrome-axonal neuropathy-hypogonadotropic hypogonadism syndrome 11.7
50 ataxia - hypogonadism - choroidal dystrophy 11.7

Graphical network of the top 20 diseases related to Hypogonadotropism:



Diseases related to Hypogonadotropism

Symptoms & Phenotypes for Hypogonadotropism

MGI Mouse Phenotypes related to Hypogonadotropism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.72 KISS1 KISS1R PRL GNRH1 GNRHR
2 digestive/alimentary MP:0005381 9.67 GNRHR KISS1 KISS1R GNRH1
3 integument MP:0010771 9.65 KISS1 KISS1R PRL GNRH1 GNRHR
4 liver/biliary system MP:0005370 9.46 KISS1 KISS1R PRL GNRH1
5 renal/urinary system MP:0005367 9.26 KISS1 KISS1R GNRH1 GNRHR
6 reproductive system MP:0005389 9.1 KISS1 KISS1R PRL RNF216 GNRH1 GNRHR

Drugs & Therapeutics for Hypogonadotropism

Drugs for Hypogonadotropism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 202)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 7440-66-6 23994
2
Dihydrotachysterol Approved Phase 4,Phase 2,Phase 1 67-96-9 5281010 5311071
3 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable,Early Phase 1 979-32-8
4
Testosterone undecanoate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 5949-44-0
5
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable,Early Phase 1 50-28-2 5757
6
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-22-0 6013
7
Methyltestosterone Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-18-4 6010
8
Polyestradiol phosphate Approved Phase 4,Phase 3,Not Applicable,Early Phase 1 28014-46-2
9
Testosterone enanthate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 315-37-7 9416
10
Anastrozole Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1 120511-73-1 2187
11
Metformin Approved Phase 4,Phase 3,Phase 2 657-24-9 14219 4091
12
Progesterone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 57-83-0 5994
13
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
14
Dutasteride Approved, Investigational Phase 4,Phase 2,Phase 1 164656-23-9 152945 6918296
15
Menotropins Approved Phase 4,Not Applicable 61489-71-2, 9002-68-0 5360545
16
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 1406-16-2
17
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 3 67-97-0 6221 5280795
18
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3 50-14-6 5280793
19
N,N-dimethylarginine Experimental Phase 4 30315-93-6 123831
20 insulin Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
21 Fertility Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
22 Central Nervous System Depressants Phase 4,Phase 2,Phase 1
23 Follicle Stimulating Hormone Phase 4,Phase 3,Phase 2,Not Applicable
24 Chorionic Gonadotropin Phase 4,Phase 3,Phase 2,Not Applicable
25 Anabolic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
26 Contraceptive Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
27 Testosterone 17 beta-cypionate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
28 Androgens Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
29 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
30 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
31 Vardenafil Dihydrochloride Phase 4
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
33 Vasodilator Agents Phase 4,Early Phase 1
34 Hypoglycemic Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
35 Estradiol 17 beta-cypionate Phase 4,Phase 3,Not Applicable,Early Phase 1
36 Estradiol 3-benzoate Phase 4,Phase 3,Not Applicable,Early Phase 1
37 Estrogen Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
38 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Estrogens Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
40 Phosphodiesterase 5 Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1
41 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1
42 Insulin, Globin Zinc Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
43 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2
44 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
45 decanoic acid Phase 4
46 Triptorelin Pamoate Phase 4
47 5-alpha Reductase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
48 Fenugreek seed meal Phase 4,Not Applicable
49 Micronutrients Phase 4,Phase 3,Phase 2,Not Applicable
50 Mitogens Phase 4

Interventional clinical trials:

(show top 50) (show all 347)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Pulsatile Gonadotropin Releasing Hormone Pump Treatment in Patients With Idiopathic Hypogonadotropic Hypogonadism Unknown status NCT02310074 Phase 4 Pulsatile Gonadotropin Releasing Hormone;Human chorionic gonadotropin;Urinary Follicle-Stimulating Hormone
2 Comparison of Assisted Reproductive Technology (ART) Outcomes Between Two Protocols of Induction of Ovulation in Patients With Hypogonadotropic Hypogonadism Unknown status NCT02140515 Phase 4 Lutropin alfa;Follitropin alfa and Lutropin alfa
3 Effect of Testosterone on Endothelial Function and Microcirculation in Type 2 Diabetic Patients With Hypogonadism Unknown status NCT01084369 Phase 4 Testosterone
4 Effect of Androgel on Type 2 Diabetic Males With Hypogonadism Unknown status NCT00350701 Phase 4 androgel;androgel 10g;placebo
5 Odense Androgen Study - The Effect of Testim and Training in Hypogonadal Men Unknown status NCT00700024 Phase 4 Testim;placebo
6 Open-label, Follow-up Study of Oral Testosterone Undecanoate in Hypogonadal Men Unknown status NCT01699178 Phase 4 Oral testosterone undecanoate;Transdermal testosterone gel (AndroGel)
7 Testosterone for Peripheral Vascular Disease Unknown status NCT00504712 Phase 4 Testosterone;0.9% saline
8 Open-Label Study, Evaluating Patient Satisfaction and Symptom Improvement When Treating Male Hypogonadism With Natesto™ Completed NCT02937740 Phase 4 NATESTO Testosterone Nasal Gel
9 Effects of Medications in Patients With Hypogonadism Completed NCT01601327 Phase 4 Testosterone enanthate (Sustanon 250 mg);Human chorionic gonadotropin (hCG) (Pregnyl 5000 IU);Testosteron gel (Testojel 50 mg)
10 Testosterone Replacement Therapy Decreases Plasma Paraoxonase 1 Enzyme Activity In Male Patients With Hypogonadism Completed NCT01107067 Phase 4 Sustanon
11 Endothelial Dysfunction, Inflammation and Insulin Resistance in Congenital Hypogonadism and Effect of Testosteron Replacement Therapy Completed NCT02171390 Phase 4 Testosterone 250mg injection;Testosteron 50 mg transdermal gel
12 Metabolic Syndrome Criteria and the Effect of Testosterone Treatment in Young Men With Hypogonadism Completed NCT01160341 Phase 4 Testosteron
13 Visceral Adiposity Index and Triglyceride/High-density Lipoprotein Cholesterol Ratio in the Congenital Hypogonadotropic Hypogonadism and Effect of Testosteron Treatment Completed NCT02111434 Phase 4 Testosterone
14 Sequential Therapy for Hypogonadotropic Hypogonadism Completed NCT01403532 Phase 4 Traditional intervention for HH using HCG and FSH;Sequential intervention for HH using HCG and FSH;Sequential intervention for HH using HCG and FSH plus zinc
15 The Effect of Testosteron Replacement Treatment on the Fibroblast Growth Factor-23, Asymmetric Dimethylarginine and Vitamin D Levels in the Congenital Hypogonadotropic Hypogonadism Completed NCT02111473 Phase 4 Testosterone
16 The Effect of Testosterone Replacement on Endothelial Dysfunction, Inflammation and Insulin Resistance in Male Hypogonadotrophic Hypogonadism Completed NCT01533129 Phase 4 Testogel 50 mg transdermal gel;Testosterone 250mg injection
17 Vitamin D Treatment and Hypogonadism in Men Completed NCT01748370 Phase 4 Vitamin D supplementation in hypogonadal men;Vitamin D supplementation in eugonadal men;Placebo hypogonadal;Placebo eugonadal
18 Effects of Testosterone on Myocardial Repolarization Completed NCT03126656 Phase 4 Testosterone Undecanoate
19 The Effect of Testosterone Replacement on the High Density Lipoprotein Cholesterol Subgroups Completed NCT01454011 Phase 4 Testosteron 250mg injection;Testosterone 50mg transdermal application
20 Testosterone Replacement in Men With Diabetes and Obesity Completed NCT01127659 Phase 4 testosterone;placebo
21 MRI Substudy; Metabolic Changes Due to Iatrogenic Hypogonadism Completed NCT02102646 Phase 4 Triptorelin
22 The Therapy of Nebido as Mono or in Combination With PDE-5 Inhibitors in Hypogonadal Patients With Erectile Dysfunction Completed NCT00421460 Phase 4 Testosterone Undecanoate,1000mg
23 TRADE-Testosterone Replacement and Dutasteride Effectiveness Completed NCT00194675 Phase 4 Dutasteride;Testosterone gel;Placebo dutasteride
24 TRT on BPH Hypoganadal MetS Patients. Florence-PROTEST Completed NCT02366975 Phase 4 Testosterone gel 2%
25 Efficacy of Fenugreek Seed and Lespedeza Cuneata in TDS Completed NCT03057899 Phase 4 TFG capsules (200 mg /capsule);Placebo oral capsule
26 The Effect of Testosterone Topical Solution (LY900011) in Hypogonadal Men With Suboptimal Response to a Topical Testosterone Gel Completed NCT01893281 Phase 4 Topical Testosterone Solution
27 Efficacy Study for Use of Dutasteride (Avodart) With Testosterone Replacement Completed NCT00752869 Phase 4 dutasteride;placebo
28 Effect of Testosterone Replacement on Insulin Resistance Completed NCT00487734 Phase 4 Placebo for testosterone gel
29 Testosterone Replacement in Diabetes With Vascular Disease (Version 2) Completed NCT00355537 Phase 4 Testosterone;0.9% saline
30 Estrogen Dosing in Turner Syndrome: Pharmacology and Metabolism Completed NCT00837616 Phase 4 17 B estradiol orally;17 B estradiol
31 Testosterone for Men With Insulin Treated Type 2 Diabetes Completed NCT00349362 Phase 4 Testosterone;0.9% saline
32 Testosterone Replacement in Metabolic Syndrome and Inflammation Completed NCT01123278 Phase 4 Testosterone;Placebo
33 Aripiprazole and Prolactin Study Completed NCT01085383 Phase 4 Aripiprazole
34 Testosterone Replacement in Older Men and Atherosclerosis Progression Completed NCT00287586 Phase 4 Testosterone Gel (Androgel);Placebo
35 Subcutaneous vs. Intramuscular Testosterone Completed NCT03091348 Phase 4 Testosterone
36 Testosterone Therapy of Men With Type 2 Diabetes Mellitus (T2DM) Completed NCT01560546 Phase 4 Testosterone;Placebo
37 Severe LH Suppressed Patients After Administration of a GnRH Antagonist Completed NCT01936077 Phase 4 Recombinant LH (Luveris)
38 FSH/LH Ratio as a Predictor of IVF Outcome in Young and Older Women Completed NCT02674178 Phase 4
39 Neuroendocrine Dysfunction in Traumatic Brain Injury: Effects of Testosterone Therapy Completed NCT01201863 Phase 4 Androgel (Testosterone Gel);Androgel Placebo
40 Human Menopausal Gonadotropin Combining With Human Chorionic Gonadotropin Treat Congenital Hypogonadotropic Hypogonadism Recruiting NCT02880280 Phase 4 Human Menopausal Gonadotropin;Human Chorionic Gonadotropin
41 Aromatase Inhibitors and Weight Loss in Severely Obese Men With Hypogonadism Recruiting NCT03490513 Phase 4 anastrozole (1 mg/day);Placebo
42 Testosterone Therapy in Hypogonadal Men Treated With Opioids Recruiting NCT02433730 Phase 4 Testosterone;placebo
43 Aromatase Inhibitors and Weight Loss in Severely Obese Hypogonadal Male Veterans (Pilot) Recruiting NCT02959853 Phase 4 Anastrazole
44 Natesto Effects on Testosterone, Luteinizing Hormone, Follicle Stimulating Hormone and Semen Parameters Recruiting NCT03203681 Phase 4 NATESTO® (4.5% nasal testosterone) Nasal Gel
45 Periodontal Profile of Hypogonadic Men Recruiting NCT03176537 Phase 4 Testosterone gel;Placebos
46 A Study to Evaluate the Effect of Testosterone Replacement Therapy (TRT) on the Incidence of Major Adverse Cardiovascular Events (MACE) and Efficacy Measures in Hypogonadal Men ( TRAVERSE ) Recruiting NCT03518034 Phase 4 Testosterone;Placebo
47 TESTO: Testosterone Effects on Short-Term Outcomes in Infants With XXY Recruiting NCT03325647 Phase 4 Testosterone Cypionate 200 Milligram/Milliliter Injectable Solution;Placebo injectable saline
48 The Health Influences of Puberty (HIP) Study Active, not recruiting NCT01775813 Phase 4 Metformin
49 Body Composition in Infants With Klinefelter Syndrome and Effects of Testosterone Treatment Active, not recruiting NCT02408445 Phase 4 testosterone cypionate 200mg/ml
50 NEBIDO in Symptomatic Late Onset Hypogonadism (SLOH) Terminated NCT01092858 Phase 4 Testosterone Undeconate (Nebido, BAY86-5037);Placebo

Search NIH Clinical Center for Hypogonadotropism

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Hypogonadotropism

Anatomical Context for Hypogonadotropism

MalaCards organs/tissues related to Hypogonadotropism:

41
Bone, Prostate, Testes, Pituitary, Brain, Heart, Endothelial

Publications for Hypogonadotropism

Articles related to Hypogonadotropism:

(show top 50) (show all 442)
# Title Authors Year
1
Predictive factors for pituitary response to pulsatile GnRH therapy in patients with congenital hypogonadotropic hypogonadism. ( 29516878 )
2018
2
The effects of low-dose human chorionic gonadotropin combined with human menopausal gonadotropin protocol on women with hypogonadotropic hypogonadism undergoing ovarian stimulation for in vitro fertilization. ( 28960429 )
2018
3
FGFR1 disruption identified by whole genome sequencing in a male with a complex chromosomal rearrangement and hypogonadotropic hypogonadism. ( 29160040 )
2018
4
Health-related physical fitness and quality of life in men with congenital hypogonadotropic hypogonadism. ( 29430665 )
2018
5
MRI of ectopic posterior pituitary gland with dysgenesis of pituitary stalk in a patient with hypogonadotropic hypogonadism. ( 29887929 )
2018
6
Semen quality in patients with pituitary disease and adult-onset hypogonadotropic hypogonadism. ( 29514896 )
2018
7
Deficiency in GnRH receptor trafficking due to a novel homozygous mutation causes idiopathic hypogonadotropic hypogonadism in three prepubertal siblings. ( 29777911 )
2018
8
Infertility treatment strategy involving combined freeze-all embryos and single vitrified-warmed embryo transfer during hormonal replacement cycle for in vitro fertilization of women with hypogonadotropic hypogonadism. ( 29436143 )
2018
9
DCC/NTN1 complex mutations in patients with congenital hypogonadotropic hypogonadism impair GnRH neuron development. ( 29202173 )
2018
10
GENETICS IN ENDOCRINOLOGY: Genetic counseling for congenital hypogonadotropic hypogonadism and Kallmann syndrome: new challenges in the era of oligogenism and next-generation sequencing. ( 29330225 )
2018
11
Congenital Hypogonadotropic Hypogonadism and Constitutional Delay of Growth and Puberty Have Distinct Genetic Architectures. ( 29419413 )
2018
12
Transition of Care from Childhood to Adulthood: Congenital Hypogonadotropic Hypogonadism. ( 29886503 )
2018
13
Hypogonadotropic Hypogonadism in Men With Diabesity. ( 29934480 )
2018
14
Hypogonadotropic Hypogonadism in Males with Glycogen Storage Disease Type 1. ( 28160246 )
2017
15
SOX2 nonsense mutation in a patient clinically diagnosed with non-syndromic hypogonadotropic hypogonadism. ( 28659543 )
2017
16
Successful pregnancy and live birth from a hypogonadotropic hypogonadism woman with low serum estradiol concentrations despite numerous oocyte maturations: a case report. ( 28931393 )
2017
17
Developing and evaluating rare disease educational materials co-created by expert clinicians and patients: the paradigm of congenital hypogonadotropic hypogonadism. ( 28320476 )
2017
18
KLB, encoding I^-Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism. ( 28754744 )
2017
19
Beyond hormone replacement: quality of life in women with congenital hypogonadotropic hypogonadism. ( 28698240 )
2017
20
Clinical characteristics of 138 Chinese female patients with idiopathic hypogonadotropic hypogonadism. ( 29018155 )
2017
21
A patient with van Maldergem syndrome with endocrine abnormalities, hypogonadotropic hypogonadism, and breast aplasia/hypoplasia. ( 29046692 )
2017
22
Anti-MA1llerian Hormone and Ovarian Morphology in Women With Isolated Hypogonadotropic Hypogonadism/Kallmann Syndrome: Effects of Recombinant Human FSH. ( 28324034 )
2017
23
Controlled ovarian stimulation and IVF pregnancy in a trisomy X carrier with associated hypogonadotropic hypogonadism. ( 28485664 )
2017
24
Evaluating CHARGE syndrome in congenital hypogonadotropic hypogonadism patients harboring CHD7 variants. ( 29144511 )
2017
25
GNRHR biallelic and digenic mutations in patients with normosmic congenital hypogonadotropic hypogonadism. ( 28611058 )
2017
26
Characteristics of a nationwide cohort of patients presenting with Isolated Hypogonadotropic Hypogonadism (IHH). ( 28882981 )
2017
27
Hypogonadotropic hypogonadism in human immunodeficiency virus-infected men: uncommonly low testosterone levels. ( 28924485 )
2017
28
Split hand/foot malformation: a potential clue to underlying FGFR1 mutation in patients with isolated congenital hypogonadotropic hypogonadism. ( 29146774 )
2017
29
Genetic testing facilitates prepubertal diagnosis of congenital hypogonadotropic hypogonadism. ( 28195315 )
2017
30
Congenital hypogonadotropic hypogonadism, functional hypogonadotropism or constitutional delay of growth and puberty? An analysis of a large patient series from a single tertiary center. ( 27927844 )
2017
31
Reversal of hypogonadotropic hypogonadism with spontaneous pregnancy in beta-thalassaemia major with transfusional haemosiderosis. ( 28830631 )
2017
32
Kallmann syndrome: phenotype and genotype of hypogonadotropic hypogonadism. ( 29108899 )
2017
33
MicroRNA-7a2 suppression causes hypogonadotropism and uncovers signaling pathways in gonadotropes. ( 28218621 )
2017
34
Expanding the genetic spectrum of ANOS1 mutations in patients with congenital hypogonadotropic hypogonadism. ( 28122887 )
2017
35
A novel DAX-1 mutation in two male siblings presenting with precocious puberty and late-onset hypogonadotropic hypogonadism. ( 28284037 )
2017
36
Boucher NeuhAouser Syndrome - A rare cause of inherited hypogonadotropic hypogonadism. A case of two adult siblings with two novel mutations in PNPLA6. ( 27866050 )
2017
37
Oxytocin intranasal administration as a new hope for hypogonadotropic hypogonadism patients. ( 29150303 )
2017
38
FGFR1 Analyses in Four Patients with Hypogonadotropic Hypogonadism with Split-Hand/Foot Malformation: Implications for the Promoter Region. ( 28087897 )
2017
39
Idiopathic hypogonadotropic hypogonadism reversal after testosterone replacement in a 34-year-old male. ( 28583920 )
2017
40
Molecular genetic and clinical delineation of 22 patients with congenital hypogonadotropic hypogonadism. ( 28915117 )
2017
41
Bone mineral density in older patients with never-treated congenital hypogonadotropic hypogonadism. ( 28577250 )
2017
42
Hypogonadotropic hypogonadism in a female patient with congenital arhinia. ( 27941181 )
2017
43
Induction of puberty with human chorionic gonadotropin (hCG) followed by reversal of hypogonadotropic hypogonadism in Kallmann syndrome. ( 29022642 )
2017
44
Update on the Genetics of Idiopathic Hypogonadotropic Hypogonadism. ( 29280744 )
2017
45
Molecular and Genetic Aspects of Congenital Isolated Hypogonadotropic Hypogonadism. ( 28476224 )
2017
46
CCDC141 Mutations in Idiopathic Hypogonadotropic Hypogonadism. ( 28324054 )
2017
47
Clinical and genetic features of 64 young male paediatric patients with congenital hypogonadotropic hypogonadism. ( 28833369 )
2017
48
Hypogonadotropic hypogonadism in men with hereditary hemochromatosis. ( 28694969 )
2017
49
Similarity of female central (hypogonadotropic) hypogonadism and postmenopause. ( 28438051 )
2017
50
Circulating makorin ring-finger protein-3 (MKRN3) levels in healthy men and in men with hypogonadotropic hypogonadism. ( 26175221 )
2016

Variations for Hypogonadotropism

Expression for Hypogonadotropism

Search GEO for disease gene expression data for Hypogonadotropism.

Pathways for Hypogonadotropism

GO Terms for Hypogonadotropism

Biological processes related to Hypogonadotropism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 female pregnancy GO:0007565 8.96 GNRH1 PRL
2 G-protein coupled receptor signaling pathway GO:0007186 8.92 GNRH1 GNRHR KISS1 KISS1R

Molecular functions related to Hypogonadotropism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 GNRH1 PRL

Sources for Hypogonadotropism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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