MCID: HYP022
MIFTS: 36

Hypohidrosis

Categories: Skin diseases

Aliases & Classifications for Hypohidrosis

MalaCards integrated aliases for Hypohidrosis:

Name: Hypohidrosis 12 29 55 44 15 73
Oligohidrosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11155
ICD10 33 L74.4
MeSH 44 D007007
NCIt 50 C34718
SNOMED-CT 68 45004005
UMLS 73 C0020620

Summaries for Hypohidrosis

MalaCards based summary : Hypohidrosis, also known as oligohidrosis, is related to ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant and ectodermal dysplasia. An important gene associated with Hypohidrosis is COG6 (Component Of Oligomeric Golgi Complex 6), and among its related pathways/superpathways is TNFs bind their physiological receptors. Affiliated tissues include skin, testes and brain, and related phenotypes are craniofacial and integument

Wikipedia : 76 Hypohidrosis is diminished sweating in response to appropriate stimuli. In contrast with hyperhidrosis... more...

Related Diseases for Hypohidrosis

Diseases related to Hypohidrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant 31.7 EDARADD EDAR
2 ectodermal dysplasia 31.3 TP63 EDARADD EDAR EDA
3 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 31.1 MSX1 EDARADD EDAR EDA
4 hypotrichosis 29.8 EDARADD EDAR EDA
5 hypohidrosis with abnormal palmar dermal ridges 12.2
6 shaheen syndrome 11.7
7 ichthyosis, congenital, autosomal recessive 11 11.5
8 anhidrosis 11.4
9 fabry disease 11.4
10 naegeli-franceschetti-jadassohn syndrome 11.4
11 bazex syndrome 11.4
12 witkop syndrome 11.3
13 helix syndrome 11.2
14 dermatopathia pigmentosa reticularis 11.1
15 lelis syndrome 11.1
16 ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant 11.1
17 ameloonychohypohidrotic syndrome 11.0
18 ankyloblepharon-ectodermal defects-cleft lip/palate 10.9
19 rapp-hodgkin syndrome 10.9
20 ectodermal dysplasia, hypohidrotic, with hypothyroidism and ciliary dyskinesia 10.9
21 pigmentary disorder, reticulate, with systemic manifestations, x-linked 10.9
22 ectodermal dysplasia 1, hypohidrotic, x-linked 10.9
23 limb-mammary syndrome 10.9
24 immunodeficiency 10 10.9
25 ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive 10.9
26 poikiloderma, hereditary fibrosing, with tendon contractures, myopathy, and pulmonary fibrosis 10.9
27 ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type 10.9
28 autosomal recessive congenital ichthyosis 10.9
29 ichthyosis follicularis atrichia photophobia syndrome 10.9
30 zlotogora syndrome 10.9
31 cholinergic urticaria 10.4
32 urticaria 10.4
33 alopecia 10.2
34 miliaria 10.2
35 hard palate cancer 10.1 MSX1 KRT14
36 mycosis fungoides 10.1
37 cleft lip and alveolus 10.1 TP63 MSX1
38 hypohidrotic ectodermal dysplasia autosomal recessive 10.1 EDARADD EDAR
39 isolated cleft lip 10.1 TP63 MSX1
40 ameloblastic carcinoma 10.0 TP63 KRT14
41 lipoadenoma 10.0 TP63 KRT14
42 limbal stem cell deficiency 10.0 TP63 KRT14
43 pinguecula 10.0 TP63 KRT14
44 ichthyosis 10.0
45 adenocarcinoma 10.0
46 spindle cell carcinoma 10.0 TP63 KRT14
47 myoepithelioma 10.0 TP63 KRT14
48 fibular aplasia or hypoplasia, femoral bowing and poly-, syn-, and oligodactyly 10.0 MSX1 EDARADD EDAR
49 pleomorphic adenoma 10.0 TP63 KRT14
50 cleft lip/palate 9.9 TP63 MSX1

Graphical network of the top 20 diseases related to Hypohidrosis:



Diseases related to Hypohidrosis

Symptoms & Phenotypes for Hypohidrosis

MGI Mouse Phenotypes related to Hypohidrosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.65 EDAR EDARADD KRT14 MSX1 TP63
2 integument MP:0010771 9.55 EDAR EDARADD KRT14 MSX1 TP63
3 limbs/digits/tail MP:0005371 9.26 EDAR EDARADD MSX1 TP63
4 vision/eye MP:0005391 9.1 EDAR EDARADD GLA KRT14 MSX1 TP63

Drugs & Therapeutics for Hypohidrosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dosing Study of Replagal in Patients With Fabry Disease Completed NCT00068107 Phase 2 Replagal
2 An Open-Label Clinical Trial of Replagal Enzyme Therapy in Children Ages 7-17 Years With Fabry Disease Completed NCT00071877 Phase 2 Replagal
3 A Study of Norepinephrine in Patients With Congenital Insensitivity to Pain and Anhidrosis Withdrawn NCT02624310 Phase 2 Droxidopa (L-DOPS);Placebo
4 Enzyme Replacement Therapy in Fabry Disease Terminated NCT00149318

Search NIH Clinical Center for Hypohidrosis

Cochrane evidence based reviews: hypohidrosis

Genetic Tests for Hypohidrosis

Genetic tests related to Hypohidrosis:

# Genetic test Affiliating Genes
1 Hypohidrosis 29

Anatomical Context for Hypohidrosis

MalaCards organs/tissues related to Hypohidrosis:

41
Skin, Testes, Brain, Bone, Pituitary

Publications for Hypohidrosis

Articles related to Hypohidrosis:

(show top 50) (show all 86)
# Title Authors Year
1
Serum carcinoembryonic antigen as a clinical marker in hypohidrosis. ( 30251254 )
2018
2
Serum carcinoembryonic antigen specifically increases among various serum markers of adenocarcinoma in hypohidrosis or conditions related to hypohidrosis. ( 28295553 )
2017
3
Hypothalamic-pituitary germinoma presenting as generalized hypohidrosis. ( 28202423 )
2017
4
Palmoplantar hyperhidrosis: A paradoxical presentation of acquired idiopathic generalized hypohidrosis. ( 28540873 )
2017
5
A case of cholinergic urticaria with localized hypohidrosis showing sweat gland eosinophilic infiltration. ( 28108244 )
2017
6
Skin Ultrastructural Findings in Acquired Generalized Hypohidrosis/Anhidrosis in a Patient with Subclinical SjAPgren Syndrome. ( 28448095 )
2017
7
Localized hypohidrosis is an unrecognized sequela of herpes zoster. ( 27986141 )
2017
8
Reticulate Hyperpigmentation in a Man With Hypohidrosis and Sinopulmonary Infections. ( 28273282 )
2017
9
Pansclerotic morphea associated with hypohidrosis and anti-M3 muscarinic acetylcholine receptor antibodies. ( 28977673 )
2017
10
Hypohidrosis and metal allergy: Trigger factors for unilateral lichen planus. ( 28342246 )
2017
11
Elevation of serum carcinoembryonic antigen in a case of cholinergic urticaria with failed detection of hypohidrosis by the conventional starch-iodine test. ( 27864842 )
2016
12
A Mutation in the Tubulin-Encoding TUBB3 Gene Causes Complex Cortical Malformations and Unilateral Hypohidrosis. ( 28503613 )
2016
13
Hypohidrosis in Individuals with Exertional Heat Injury: A Prospective Open Cohort Study. ( 26402230 )
2015
14
Application of iodinated starch powder using an atomizer spray gun - a new and effective tool to evaluate hypohidrosis. ( 26452436 )
2015
15
First case of congenital idiopathic hypohidrosis in China. ( 26560219 )
2015
16
Decreased expression of acetylcholine esterase in cholinergic urticaria with hypohidrosis or anhidrosis. ( 23748235 )
2014
17
Hypohidrosis: an early clue in the diagnosis of Fabry disease. ( 25546261 )
2014
18
Approach to hypohidrosis. ( 24629071 )
2014
19
Approach to hypohidrosis. ( 23094789 )
2013
20
Hypohidrosis induced by topiramate in an adult patient. ( 23773932 )
2013
21
Horner's syndrome with a sensation of warmth due to hypohidrosis. ( 23903517 )
2013
22
Detection of hypohidrosis in Japanese patients with pigmentary mosaicism. ( 24184501 )
2013
23
Successful treatment of syringotropic CD8+ mycosis fungoides accompanied by hypohidrosis with vorinostat and retinoids. ( 22963521 )
2013
24
A novel syndrome of hypohidrosis and intellectual disability is linked to COG6 deficiency. ( 23606727 )
2013
25
Hypohidrosis Plays a Crucial Role in the Vicious Circle of Bathing Suit Ichthyosis: A Case with Summer Exacerbation. ( 24158451 )
2013
26
Granulysin-Bearing Cells in the Skin Lesions of Acute Graft-versus-Host Disease: Possible Mechanisms for Hypohidrosis in Graft-versus-Host Disease. ( 23626547 )
2013
27
Evaluation of sweat production by pilocarpine iontophoresis: a noninvasive screening tool for hypohidrosis in ectodermal dysplasia. ( 24426251 )
2013
28
Poikiloderma, hyperpigmentation, alopecia, hypohidrosis, malformed bones, lymphedema of the legs and decreased cortisol level: a new entity? ( 23330946 )
2013
29
Hypohidrosis and hyperthermia during topiramate treatment in children. ( 23427516 )
2012
30
Efficacy of stellate ganglion block in cholinergic urticaria with acquired generalized hypohidrosis. ( 23091692 )
2012
31
Cholinergic urticaria associated with acquired hypohidrosis: an ultrastructural study. ( 21103837 )
2011
32
Epileptic seizures and cholinergic urticaria with generalized hypohidrosis or anhidrosis. ( 21233059 )
2011
33
A case of disseminated DLE complicated by atopic dermatitis and SjAPgren's syndrome: link between hypohidrosis and skin manifestations. ( 20824298 )
2011
34
A case of cholinergic urticaria associated with acquired generalized hypohidrosis and reduced acetylcholine receptors: cause and effect? ( 21392081 )
2011
35
Reversible hypohidrosis with topiramate therapy for chronic migraine. ( 20236344 )
2010
36
Hypohidrosis-related symptoms in pediatric epileptic patients with topiramate. ( 19549063 )
2010
37
A case of cholinergic urticaria associated with acquired generalized hypohidrosis and abnormal neurological findings: association with incomplete Ross syndrome? ( 20199537 )
2010
38
Granulomatous mycosis fungoides with hypohidrosis mimicking lepromatous leprosy. ( 21079314 )
2010
39
Early blistering, poikiloderma, hypohidrosis, alopecia and exocrine pancreatic hypofunction: a peculiar variant of Rothmund-Thomson syndrome? ( 18952524 )
2008
40
Drug-induced hyperhidrosis and hypohidrosis: incidence, prevention and management. ( 18217788 )
2008
41
Electrophysiological study in 2 children with transient hypohidrosis induced by topiramate. ( 19050411 )
2008
42
Topiramate associated hypohidrosis and hyperthermia. ( 18367774 )
2008
43
Hypohidrosis colocalized with Becker's naevus. ( 17263814 )
2007
44
Goosefleshlike lesions and hypohidrosis. ( 17938352 )
2007
45
Ectodermal dysplasia with alopecia, onychodysplasia, hypohidrosis, keratoderma, abnormal teeth and deafness. ( 18032861 )
2007
46
Successful steroid treatment of acquired idiopathic partial hypohidrosis. ( 16674791 )
2006
47
Hypohidrosis during topiramate treatment: a rare and reversible side effect. ( 16648001 )
2006
48
Harlequin sign (hemifacial flushing and contralateral hypohidrosis) in a 4-year-old girl with Horner syndrome. ( 16918633 )
2006
49
Cholinergic urticaria and hypohidrosis: a clinical reappraisal. ( 17135748 )
2006
50
A 52-year-old man with hypohidrosis. ( 17203598 )
2006

Variations for Hypohidrosis

Expression for Hypohidrosis

Search GEO for disease gene expression data for Hypohidrosis.

Pathways for Hypohidrosis

Pathways related to Hypohidrosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.28 EDA EDAR EDARADD

GO Terms for Hypohidrosis

Biological processes related to Hypohidrosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.81 EDA EDAR EDARADD TP63
2 multicellular organism development GO:0007275 9.72 EDA EDAR EDARADD MSX1 TP63
3 epithelial cell differentiation GO:0030855 9.52 KRT14 TP63
4 embryonic limb morphogenesis GO:0030326 9.49 MSX1 TP63
5 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.48 EDA EDAR
6 hair follicle development GO:0001942 9.46 EDAR TP63
7 pigmentation GO:0043473 9.43 EDA EDAR
8 epidermis development GO:0008544 9.43 EDAR KRT14 TP63
9 embryonic forelimb morphogenesis GO:0035115 9.4 MSX1 TP63
10 embryonic hindlimb morphogenesis GO:0035116 9.37 MSX1 TP63
11 tumor necrosis factor-mediated signaling pathway GO:0033209 9.33 EDA EDAR EDARADD
12 salivary gland cavitation GO:0060662 8.96 EDA EDAR
13 odontogenesis of dentin-containing tooth GO:0042475 8.92 EDA EDAR MSX1 TP63

Molecular functions related to Hypohidrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 p53 binding GO:0002039 8.62 MSX1 TP63

Sources for Hypohidrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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