Aliases & Classifications for Hypokalemia

MalaCards integrated aliases for Hypokalemia:

Name: Hypokalemia 12 76 29 55 6 44 15
Potassium Deficiency Disorder 12 73
Potassium Deficiency 76 73
Hypopotassemia 12
Potassium 43

Classifications:



External Ids:

Disease Ontology 12 DOID:4500
MeSH 44 D007008
NCIt 50 C34939
ICD10 33 E87.6

Summaries for Hypokalemia

MedlinePlus : 43 Potassium is a mineral that your body needs to work properly. It is a type of electrolyte. It helps your nerves to function and muscles to contract. It helps your heartbeat stay regular. It also helps move nutrients into cells and waste products out of cells. A diet rich in potassium helps to offset some of sodium's harmful effects on blood pressure. Many people get all the potassium they need from what they eat and drink. Sources of potassium in the diet include Leafy greens, such as spinach and collards Fruit from vines, such as grapes and blackberries Root vegetables, such as carrots and potatoes Citrus fruits, such as oranges and grapefruit Your kidneys help to keep the right amount of potassium in your body. If you have chronic kidney disease, your kidneys may not remove extra potassium from the blood. Some medicines also can raise your potassium level. You may need a special diet to lower the amount of potassium that you eat.

MalaCards based summary : Hypokalemia, also known as potassium deficiency disorder, is related to seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance and diabetes insipidus, nephrogenic, autosomal. An important gene associated with Hypokalemia is SLC12A3 (Solute Carrier Family 12 Member 3), and among its related pathways/superpathways are Peptide hormone metabolism and Renin secretion. The drugs Furosemide and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and lung, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 76 Hypokalemia, also spelled hypokalaemia, is a low level of potassium (K+) in the blood serum. Normal... more...

Related Diseases for Hypokalemia

Diseases related to Hypokalemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 239)
# Related Disease Score Top Affiliating Genes
1 seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance 32.3 AQP2 SLC12A3
2 diabetes insipidus, nephrogenic, autosomal 32.1 AQP2 CASR SLC12A1
3 liddle syndrome 31.9 HSD11B2 NR3C1 REN
4 apparent mineralocorticoid excess 30.9 CLCNKB HSD11B2 NR3C1 POMC REN
5 hyperaldosteronism, familial, type i 30.8 HSD11B2 NR3C1 POMC REN
6 gitelman syndrome 29.9 BSND CASR CLCNKB KCNJ1 REN SLC12A1
7 adenoma 29.9 CASR HSD11B2 POMC
8 hyporeninemic hypoaldosteronism 29.5 ACE REN
9 malignant hypertension 29.5 ACE REN
10 nephrocalcinosis 29.4 CLCNKB KCNJ1 SLC12A1
11 bartter disease 29.2 BSND CASR CLCNKB KCNJ1 REN SLC12A1
12 fibromuscular dysplasia 29.1 ACE REN
13 chronic kidney failure 29.1 ACE CASR REN
14 bartter syndrome, type 3 29.1 BSND CLCNKB KCNJ1 REN SLC12A1 SLC12A3
15 hypoaldosteronism 29.0 ACE POMC REN
16 diabetes insipidus 29.0 AQP2 POMC REN SLC12A1
17 congestive heart failure 29.0 ACE AQP2 REN
18 kidney disease 28.7 ACE AQP2 CASR REN
19 conn's syndrome 28.4 CLCNKB HSD11B2 NR3C1 POMC REN SLC12A3
20 hypertension, essential 26.8 ACE HSD11B2 NR3C1 POMC REN SLC12A1
21 myotonia, potassium-aggravated 12.5
22 hypertensive hypokalemia familial 11.9
23 sodium-potassium-atpase activity of red cell 11.9
24 vipoma 11.6
25 thyrotoxic periodic paralysis 11.4
26 renal tubular acidosis, distal 11.4
27 thyrotoxic periodic paralysis 1 11.3
28 wdha syndrome 11.2
29 hypokalemic periodic paralysis, type 1 11.1
30 hypocalcemia, autosomal dominant 1 11.1
31 thyrotoxic periodic paralysis 2 11.1
32 hypokalemic alkalosis, familial, with specific renal tubulopathy 11.1
33 hypomagnesemia 2, renal 11.0
34 hyperaldosteronism, familial, type iii 11.0
35 kindler syndrome 10.9
36 hyperaldosteronism, familial, type ii 10.9
37 arthrogryposis, distal, type 3 10.8 REN SLC12A3
38 adrenal hyperplasia, congenital, due to 17-alpha-hydroxylase deficiency 10.8
39 diarrhea 1, secretory chloride, congenital 10.8
40 bartter syndrome, type 5, antenatal, transient 10.8
41 diabetes insipidus, nephrogenic, x-linked 10.8
42 primary aldosteronism, seizures, and neurologic abnormalities 10.8
43 primary hypomagnesemia 10.8
44 hyper-reninism 10.8
45 slc4a1-associated distal renal tubular acidosis 10.8
46 impaired renal function disease 10.6 AQP2 SLC12A1
47 acute adrenal insufficiency 10.5 POMC REN
48 bartter syndrome, type 2, antenatal 10.5 CASR KCNJ1
49 hypercalciuria, absorptive, 2 10.4 CASR KCNJ1
50 adrenal cortical hypofunction 10.4 POMC REN

Graphical network of the top 20 diseases related to Hypokalemia:



Diseases related to Hypokalemia

Symptoms & Phenotypes for Hypokalemia

MGI Mouse Phenotypes related to Hypokalemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.2 HSD11B2 BSND CACNA1S KCNJ1 CASR ACE
2 cardiovascular system MP:0005385 10.17 HSD11B2 BSND KCNH2 CACNA1S KCNJ1 ACE
3 homeostasis/metabolism MP:0005376 10.17 HSD11B2 BSND KCNH2 CACNA1S KCNJ1 CASR
4 growth/size/body region MP:0005378 10.14 AQP2 KCNH2 BSND CACNA1S KCNJ1 CASR
5 hematopoietic system MP:0005397 10.02 AQP2 BSND KCNJ1 CASR ACE POMC
6 mortality/aging MP:0010768 9.93 AQP2 HSD11B2 KCNH2 BSND CACNA1S KCNJ1
7 integument MP:0010771 9.8 AQP2 CACNA1S CASR POMC KCNJ1 SLC12A1
8 muscle MP:0005369 9.43 HSD11B2 KCNH2 CACNA1S CASR REN NR3C1
9 renal/urinary system MP:0005367 9.4 HSD11B2 BSND KCNJ1 CASR ACE AQP2

Drugs & Therapeutics for Hypokalemia

Drugs for Hypokalemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 310)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Furosemide Approved, Vet_approved Phase 4,Phase 2,Phase 1,Early Phase 1 54-31-9 3440
2
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
3
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 7440-66-6 23994
4
Spironolactone Approved Phase 4,Phase 2,Phase 3,Not Applicable 1952-01-7, 52-01-7 5833
5
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-23-7 5754
6
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
7
Chlorthalidone Approved Phase 4,Phase 3,Phase 2,Not Applicable 77-36-1 2732
8
Amphotericin B Approved, Investigational Phase 4,Phase 2 1397-89-3 14956 5280965
9
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 58-93-5 3639
10
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
11
Progesterone Approved, Vet_approved Phase 4,Phase 2 57-83-0 5994
12
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
13
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 22916-47-8 4189
14
Mifepristone Approved, Investigational Phase 4 84371-65-3 55245
15
Procaterol Approved, Investigational Phase 4 72332-33-3 688561
16
Acetaminophen Approved Phase 4 103-90-2 1983
17
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
18
Entecavir Approved, Investigational Phase 4,Phase 3,Phase 2 142217-69-4 153941
19
Insulin Glargine Approved Phase 4 160337-95-1
20
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
21
Tolvaptan Approved Phase 4 150683-30-0 216237
22
Metolazone Approved Phase 4 17560-51-9 4170
23
Chlorothiazide Approved, Vet_approved Phase 4 58-94-6 2720
24 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
25 Licorice Approved, Nutraceutical Phase 4
26
Butyric Acid Experimental, Investigational Phase 4,Phase 2,Phase 3 107-92-6 264
27 insulin Phase 4,Phase 3,Phase 2,Not Applicable
28 diuretics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
29 Respiratory System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
30 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Adrenergic beta-2 Receptor Agonists Phase 4,Phase 1,Not Applicable
33 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 Albuterol Phase 4,Phase 2,Not Applicable
35 Natriuretic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
36 Sodium Potassium Chloride Symporter Inhibitors Phase 4,Phase 2,Phase 1,Early Phase 1
37 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
38 Tocolytic Agents Phase 4,Phase 1,Phase 2,Not Applicable
39 Dopamine Agents Phase 4
40 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
42 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Not Applicable
43 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Insulin, Globin Zinc Phase 4,Phase 3,Phase 2,Not Applicable
45 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1
46 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Bronchodilator Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 beta-endorphin Phase 4,Phase 3
49 Analgesics Phase 4,Phase 1,Phase 2,Not Applicable
50 calcium channel blockers Phase 4

Interventional clinical trials:

(show top 50) (show all 144)
# Name Status NCT ID Phase Drugs
1 Comparison of Enteral Versus Intravenous Potassium Supplementation Unknown status NCT02015962 Phase 4 Intravenous potassium chloride;Oral potassium chloride
2 Efficacy of KCl Plus 0.9%NaCl Compare With KCl Plus 0.45%NaCl Unknown status NCT02721095 Phase 4
3 The Effect of a Diet Based on Low Sodium and Slowly Absorbed Carbohydrates on the Incidence of Refeeding Syndrome in Patients With Head and Neck Cancer Unknown status NCT01845922 Phase 4
4 Dopamine in Acute Decompensated Heart Failure (DAD-HF) Trial Unknown status NCT00937092 Phase 4 Furosemide;low-dose dopamine + low-dose furosemide
5 Monocentric STUDY, Randomised Double Blinded (Healthy Subjects, or Transversal (Patients With Gitelman Syndrome) Completed NCT02297048 Phase 4
6 Effect of Licorice and Hydrochlorothiazide on Plasma Potassium Completed NCT00605202 Phase 4 Hydrochlorothiazide
7 Safety of Continuous Potassium Chloride Infusion in Critical Care Completed NCT00718068 Phase 4 Sterile Potassium Chloride Concentrate;Sterile Potassium Chloride Concentrate
8 Safety and Effectiveness of Short-course AmBisome in the Treatment of PKDL in Bangladesh Completed NCT03311607 Phase 4 AmBisome
9 Miralax (PEG 3350) vs. Golytely as Bowel Preparation for Screening Colonoscopy Completed NCT01170754 Phase 4 PEG-3350 and Gatorade;Golytely 4 liters
10 Early Diuresis Following Colorectal Surgery Completed NCT02351934 Phase 4 Furosemide;Celecoxib;Gabapentin
11 Comparative Study on the Efficacy and Safety of Procaterol Versus Salbutamol Given Via Metered Dose Inhaler With Spacer in the Management of Acute Asthma Attack in the Emergency Room Completed NCT01091337 Phase 4 Procaterol;Salbutamol
12 Blood Pressure Regulation - Role of Potassium Completed NCT02380157 Phase 4 Kaleorid, 750mg (trade name), Potassium chloride (active substance);Placebo
13 Efficacy of Sodium Polystyrene Sulfonate in the Treatment of Hyperkaliemia in Pre-dialysis Patients Completed NCT02065076 Phase 4 Sodium polystyrene sulfonate;Lactose with carob gum
14 Metabolism of Isotonic Versus Hypotonic Maintenance Solutions in Fasting Healthy Adults Completed NCT02822898 Phase 4 NaCl 0.9% in Glucose 5% with 40mEq Potassium;Glucion 5%
15 Diuretics for Postpartum High Blood Pressure in Preeclampsia Completed NCT02163655 Phase 4 FUROSEMIDE;Placebo
16 A Longitudinal 2-year Bone Marrow Study of Eltrombopag in Previously Treated Adults, With Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Completed NCT01098487 Phase 4 Eltrombopag olamine
17 Diuretics In the Management of Essential Hypertension (DIME) Study Completed NCT00131846 Phase 4 Thiazide diuretics;No diuretics
18 PROPHYSOME: Pilot Study on Safety of a Weekly Administration of 10mg/kg of AmBisome® in Antifungal Prophylaxis Treatment of Allogeneic Stem-cell Transplantation and Acute Leukaemia Completed NCT00362544 Phase 4 Ambisome
19 Effect of Entecavir in Blacks/African Americans and Hispanics With Chronic Hepatitis B Virus (HBV) Infection Completed NCT00371150 Phase 4 Entecavir
20 Insulin in Total Parenteral Nutrition Completed NCT02706119 Phase 4 Subcutaneous glargine insulin;Regular insulin added to TPN bag
21 Intravenous Fluids in Hospitalised Children Recruiting NCT02926989 Phase 4 Plasmalyte Glucos 50 mg/mL;0.45% saline in 5% dextrose
22 Potassium Infusion for Conversion of Atrial Fibrillation/-Flutter Recruiting NCT01818583 Phase 4 Potassium chloride;Glucose 50 MG/ML
23 The Impact of Neut During Potassium Chloride Replacement on Pain and Incidence of Phlebitis Enrolling by invitation NCT02082717 Phase 4 potassium chloride replacement;Experimental - 4% Sodium Bicarbonate
24 Comparison of Oral or Intravenous Thiazides vs Tolvaptan in Diuretic Resistant Decompensated Heart Failure Enrolling by invitation NCT02606253 Phase 4 tolvaptan;Chlorothiazide;Metolazone
25 Prospective Comparison of Metolazone Versus Chlorothiazide for Acute Decompensated Heart Failure With Diuretic Resistance Enrolling by invitation NCT03574857 Phase 4 Metolazone Oral Tablet;Chlorothiazide Injection
26 Use of Spironolactone for the Prevention of Electrolyte Abnormalities in Patients Treated With Amphotericin B Terminated NCT01843309 Phase 4 Spironolactone 100mg;Spironolactone 200mg;Placebo
27 Dopamine in Acute Decompensated Heart Failure II Terminated NCT01060293 Phase 4 High-dose furosemide;Low-dose furosemide;Low-dose furosemide combined with low-dose dopamine
28 Protocolized Diuretic Strategy in Cardiorenal Failure Terminated NCT01921829 Phase 4 Protocolized Diuretic Strategy
29 Tight Intra-Operative Glucose Control During Coronary Artery Bypass Surgery Terminated NCT00394303 Phase 4 Intraoperative continuous insulin infusion
30 ACTHAR GEL in Patients With Membranous (Class V) Lupus Nephritis Withdrawn NCT01926054 Phase 4 Acthar gel
31 The Management of Resistant Hypertension in Kidney Transplant Patients Using Chlorthalidone Withdrawn NCT02030314 Phase 4 Chlorthalidone
32 Preventing Acute Renal Failure After Cardiac Surgery in High Risk Patients Using Sodium Bicarbonate Therapy Unknown status NCT00522756 Phase 3 Sodium bicarbonate;Sodium chloride
33 Irbesartan/Hydrochlorothiazide (HCTZ) Combination Therapy for Patients With Moderate Hypertension Completed NCT00095550 Phase 3 Irbesartan/HCTZ;Irbesartan monotherapy;HCTZ monotherapy
34 Irbesartan/Hydrochlorothiazide (HCTZ) Combination Therapy as First Line Treatment for Severe Hypertension Completed NCT00095394 Phase 3 Irbesartan/HCTZ;Irbesartan monotherapy
35 Hypertension Prevention in Pre-Hypertensive Individuals Completed NCT00970931 Phase 3 Chlorthalidone plus amiloride;placebo
36 Diuretics and Angiotensin-Receptor Blocker Agents in Patients With Stage I Hypertension Completed NCT00971165 Phase 3 losartan;Chlorthalidone plus amiloride
37 SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan. Completed NCT01096654 Phase 3
38 Vitamin K2 Supplementation to Activate Matrix Gla Protein (MGP) as Endogenous Inhibitor of Vascular Calcification in Hemodialysis Patients Completed NCT01407601 Phase 3
39 Heart And Lung Failure - Pediatric INsulin Titration Trial Completed NCT01565941 Phase 3 Insulin;Insulin
40 Pazopanib Versus Placebo in Patients With Soft Tissue Sarcoma Whose Disease Has Progressed During or Following Prior Therapy Completed NCT00753688 Phase 3 PAZOPANIB;Placebo
41 Effect of Vitamin K on Age-Related Bone Loss and Vascular Calcification Completed NCT00183001 Phase 3 Vitamin K
42 Renin-angiotensin-aldosterone System (RAAS), Inflammation, and Post-Operative Atrial Fibrillation (AF) Completed NCT00141778 Phase 2, Phase 3 Placebo;Ramipril;Spironolactone
43 BMS-Reyataz Study in Treatment in Naive Subjects to Compare the Efficacy and Safety Between Boosted Reyataz and Kaletra When in Combination With Fixed Dose Truvada Completed NCT00272779 Phase 3 ATV;RTV;Tenofovi-Emtricitabine (TDF/FTC) tablet;LPV
44 Safety and Quality of Life Study of Aflibercept in Patients With Metastatic Colorectal Cancer Previously Treated With an Oxaliplatin-Based Regimen Completed NCT01571284 Phase 3 AFLIBERCEPT AVE0005;FOLFIRI
45 Extension Study to VEG105192 to Assess Pazopanib in Patients With Advanced/Metastatic Renal Cell Cancer Completed NCT00387764 Phase 3 pazopanib
46 Axitinib (AG 013736) As Second Line Therapy For Metastatic Renal Cell Cancer Completed NCT00678392 Phase 3 Axitinib (AG-013736);Sorafenib
47 A Clinical Trial Testing The Efficacy Of Crizotinib Versus Standard Chemotherapy Pemetrexed Plus Cisplatin Or Carboplatin In Patients With ALK Positive Non Squamous Cancer Of The Lung Completed NCT01154140 Phase 3 treatment;treatment
48 BIBW 2992 (Afatinib) vs Gemcitabine-cisplatin in 1st Line Non-small Cell Lung Cancer (NSCLC) Completed NCT01121393 Phase 3 Gemcitabine+Cisplatin;BIBW 2992
49 Entecavir Plus Adefovir Combination Therapy Versus Entecavir Monotherapy vs Therapy With Adefovir Plus Lamivudine for Chronic Hepatitis B Infected Subjects With Lamivudine-resistant Virus Completed NCT00410202 Phase 3 Entecavir;Tenofovir;Adefovir;Lamivudine
50 A Trial Comparing GSK1349572 50mg Plus Abacavir/Lamivudine Once Daily to Atripla (Also Called The SINGLE Trial) Completed NCT01263015 Phase 3 Dolutegravir;Atripla;Abacavir/Lamivudine;Abacavir/Lamivudine Placebo;Dolutegravir placebo;Atripla placebo

Search NIH Clinical Center for Hypokalemia

Cochrane evidence based reviews: hypokalemia

Genetic Tests for Hypokalemia

Genetic tests related to Hypokalemia:

# Genetic test Affiliating Genes
1 Hypokalemia 29

Anatomical Context for Hypokalemia

MalaCards organs/tissues related to Hypokalemia:

41
Heart, Kidney, Lung, Prostate, Liver, Myeloid, Bone

Publications for Hypokalemia

Articles related to Hypokalemia:

(show top 50) (show all 714)
# Title Authors Year
1
Genetic screening for Bartter syndrome and Gitelman syndrome pathogenic genes among individuals with hypertension and hypokalemia. ( 29953267 )
2018
2
Effects of antiarrhythmics and hypokalemia on the rate adaptation of cardiac repolarization. ( 29798684 )
2018
3
Potential Usefulness of Early Potassium Supplementation for Preventing Severe Hypokalemia Induced by Liposomal Amphotericin B in Hematologic Patients: A Retrospective Study. ( 29305017 )
2018
4
Hypokalemia: a clinical update. ( 29540487 )
2018
5
Nafcillin-Associated Hypokalemia. ( 29672332 )
2018
6
Regional anesthesia is safe and effective for lower limb orthopedic surgery in patient with renal tubular acidosis and hypokalemia. ( 29643635 )
2018
7
Chest pain as a manifestation of hypokalemia in a pediatric patient. ( 29126579 )
2018
8
Prognostic Impact of Mild Hypokalemia in Terms of Death and Stroke in the General Population-A Prospective Population Study. ( 29024624 )
2018
9
ECG Changes of Severe Hypokalemia. ( 29490087 )
2018
10
Refractory Hypokalemia from Syndrome of Apparent Mineralocorticoid Excess on Low-Dose Posaconazole. ( 29661880 )
2018
11
Clinical characterization and diagnosis of cystic fibrosis through exome sequencing in Chinese infants with Bartter-syndrome-like hypokalemia alkalosis. ( 29520692 )
2018
12
Hypokalemia in an end stage renal disease patient. ( 29842873 )
2018
13
Comments on the Prognostic Impact of Mild Hypokalemia. ( 29555045 )
2018
14
First-Episode Psychosis and Hypokalemia: A Case Report and Review of the Literature. ( 29944416 )
2018
15
Hypokalemia associated with pseudo-Cushing's syndrome and magnesium deficiency induced by chronic alcohol abuse. ( 29450857 )
2018
16
Itraconazole induced hypertension and hypokalemia: Mechanistic evaluation. ( 29385285 )
2018
17
A Young Patient with Leg Weakness and Hypokalemia-Case Report. ( 29514039 )
2018
18
A rare case of hypokalemia-induced rhabdomyolysis. ( 29915623 )
2018
19
Incident Hyperkalemia, Hypokalemia, and Clinical Outcomes During Spironolactone Treatment of Heart Failure With Preserved Ejection Fraction: Analysis of the TOPCAT Trial. ( 29572190 )
2018
20
Protection against severe hypokalemia but impaired cardiac repolarization after intense rowing exercise in healthy humans receiving salbutamol. ( 29745804 )
2018
21
Hypokalemia ( 29494072 )
2018
22
Hypokalemia due to excessive cola consumption. ( 28736066 )
2017
23
Hypokalemia Presenting as Acute Psychosis. ( 28782327 )
2017
24
Persistent severe hypokalemia: Gitelman syndrome and differential diagnosis. ( 29044344 )
2017
25
Incidence and determinants of hyperkalemia and hypokalemia in a large healthcare system. ( 28735756 )
2017
26
Torsade de Pointes Induced by Hypokalemia from Imipenem and Piperacillin. ( 28638664 )
2017
27
Diospyros rhodocalyx (Tako-Na), a Thai folk medicine, associated with hypokalemia and generalized muscle weakness: a case series. ( 28617146 )
2017
28
Central pontine myelinolysis associated with hypokalemia in a diabetic patient with sepsis. ( 28488657 )
2017
29
Reversible Hypokalemia and Bartter-Like Syndrome during Prolonged Systemic Therapy with Colistimethate Sodium in an Adult Patient. ( 28699114 )
2017
30
A Rare Cause of Severe Hypokalemia and Back Pain. ( 28881192 )
2017
31
Effect of Hypokalemia on Functional Outcome at 3 Months Post-Stroke Among First-Ever Acute Ischemic Stroke Patients. ( 28600907 )
2017
32
Analysis of Clinical and Metabolic Profile of Acute Neuromuscular Weakness Related to Hypokalemia. ( 29468618 )
2017
33
Persistent hypokalemia with renal losses in a 31-year-old pregnant woman. ( 28732701 )
2017
34
Hyperkalemia and Hypokalemia in CKD: Prevalence, Risk Factors, and Clinical Outcomes. ( 29031358 )
2017
35
Temporal Pattern and Prognostic Significance of Hypokalemia in Patients Undergoing Targeted Temperature Management Following Cardiac Arrest. ( 28803654 )
2017
36
Weakness, Hypokalemia, and Dengue. ( 29189559 )
2017
37
TETANY WITH HYPOMAGNESEMIA, HYPOKALEMIA, AND HYPOCALCEMIA AS INITIAL PRESENTATION OF CELIAC DISEASE. ( 28727665 )
2017
38
Dextrose, hypokalemia and Torsade de Pointes. ( 28062741 )
2017
39
Favorable surgical outcomes of aldosterone-producing adenoma based on lateralization by CT imaging and hypokalemia: a non-AVS-based strategy. ( 28918446 )
2017
40
Analysis of Hypokalemia as a Side Effect of Liposomal Amphotericin in Pediatric Patients. ( 28945677 )
2017
41
Tumour genesis syndrome: severe hypophosphatemia and hypokalemia may be ominous presenting findings in childhood acute myeloid leukaemia. ( 28474100 )
2017
42
Bowel preparation for colonoscopy and hypokalemia: at the heart of the problem! ( 28917345 )
2017
43
Quiz Page July 2017: An Unusual Cause of Hypokalemia. ( 28646983 )
2017
44
Meropenem Induced Hypokalemia. ( 28969183 )
2017
45
Hypokalemia during antibiotic treatment for bone and joint infections. ( 29018986 )
2017
46
An Overlooked Cause of Hypokalemia. ( 28687268 )
2017
47
Increased afterload following myocardial infarction promotes conduction-dependent arrhythmias that are unmasked by hypokalemia. ( 28798965 )
2017
48
Manifestation of hyperaldosteronism related hypokalemia in a case of anorexia nervosa. ( 28962826 )
2017
49
Recurrent Hypokalemia leading to Flaccid Quadriparesis: A Renal or Connective Tissue Disorder. ( 29220070 )
2017
50
Hypokalemia with Trifluoperazine at Therapeutic Dose. ( 28615774 )
2017

Variations for Hypokalemia

ClinVar genetic disease variations for Hypokalemia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SLC12A3 NM_000339.2(SLC12A3): c.2221G> A (p.Gly741Arg) single nucleotide variant Conflicting interpretations of pathogenicity rs138977195 GRCh37 Chromosome 16, 56921879: 56921879
2 SLC12A3 NM_000339.2(SLC12A3): c.2221G> A (p.Gly741Arg) single nucleotide variant Conflicting interpretations of pathogenicity rs138977195 GRCh38 Chromosome 16, 56887967: 56887967
3 SLC12A3 NM_000339.2(SLC12A3): c.457G> A (p.Val153Met) single nucleotide variant Uncertain significance rs779074538 GRCh37 Chromosome 16, 56902236: 56902236
4 SLC12A3 NM_000339.2(SLC12A3): c.457G> A (p.Val153Met) single nucleotide variant Uncertain significance rs779074538 GRCh38 Chromosome 16, 56868324: 56868324

Expression for Hypokalemia

Search GEO for disease gene expression data for Hypokalemia.

Pathways for Hypokalemia

Pathways related to Hypokalemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.59 ACE POMC REN
2 10.94 ACE CACNA1S REN
3 10.48 BSND CLCNKB KCNJ1 SLC12A1 SLC12A3

GO Terms for Hypokalemia

Cellular components related to Hypokalemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.8 AQP2 BSND CASR CLCNKB KCNH2 SLC12A3
2 integral component of membrane GO:0016021 9.7 ACE AQP2 BSND CACNA1S CASR CLCNKB
3 basolateral plasma membrane GO:0016323 9.54 AQP2 BSND CASR
4 apical plasma membrane GO:0016324 9.46 AQP2 CASR SLC12A1 SLC12A3
5 plasma membrane GO:0005886 9.36 ACE AQP2 BSND CACNA1S CASR CLCNKB
6 membrane GO:0016020 10.03 ACE AQP2 BSND CACNA1S CASR CLCNKB

Biological processes related to Hypokalemia according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.8 CACNA1S CLCNKB KCNH2 KCNJ1 SLC12A1 SLC12A3
2 potassium ion transport GO:0006813 9.73 KCNH2 KCNJ1 SLC12A1
3 regulation of ion transmembrane transport GO:0034765 9.73 CACNA1S CLCNKB KCNH2 KCNJ1
4 transmembrane transport GO:0055085 9.73 AQP2 CACNA1S CLCNKB KCNH2 SLC12A1 SLC12A3
5 potassium ion transmembrane transport GO:0071805 9.72 KCNH2 KCNJ1 SLC12A1
6 regulation of blood pressure GO:0008217 9.63 ACE POMC REN
7 membrane depolarization during action potential GO:0086010 9.58 CACNA1S KCNH2
8 potassium ion import GO:0010107 9.58 KCNJ1 SLC12A1 SLC12A3
9 calcium ion import GO:0070509 9.57 CACNA1S CASR
10 ion transmembrane transport GO:0034220 9.55 AQP2 BSND CLCNKB KCNJ1 SLC12A1
11 cell volume homeostasis GO:0006884 9.54 SLC12A1 SLC12A3
12 excretion GO:0007588 9.54 AQP2 CLCNKB KCNJ1
13 amyloid-beta metabolic process GO:0050435 9.52 ACE REN
14 sodium ion homeostasis GO:0055078 9.51 SLC12A1 SLC12A3
15 angiotensin maturation GO:0002003 9.49 ACE REN
16 chloride ion homeostasis GO:0055064 9.48 SLC12A1 SLC12A3
17 chloride transmembrane transport GO:1902476 9.26 BSND CLCNKB SLC12A1 SLC12A3
18 potassium ion homeostasis GO:0055075 8.8 KCNH2 SLC12A1 SLC12A3

Molecular functions related to Hypokalemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 9.46 HSD11B2 NR3C1
2 inward rectifier potassium channel activity GO:0005242 9.43 KCNH2 KCNJ1
3 voltage-gated chloride channel activity GO:0005247 9.4 BSND CLCNKB
4 potassium:chloride symporter activity GO:0015379 9.37 SLC12A1 SLC12A3
5 cation:chloride symporter activity GO:0015377 9.32 SLC12A1 SLC12A3
6 sodium ion transmembrane transporter activity GO:0015081 9.26 SLC12A1 SLC12A3
7 sodium:potassium:chloride symporter activity GO:0008511 9.16 SLC12A1 SLC12A3
8 sodium:chloride symporter activity GO:0015378 8.96 SLC12A1 SLC12A3
9 voltage-gated ion channel activity GO:0005244 8.92 CACNA1S CLCNKB KCNH2 KCNJ1

Sources for Hypokalemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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