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MCID: HYP005
MIFTS: 56

Hypokalemia

Categories: Blood diseases, Metabolic diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Hypokalemia

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MalaCards integrated aliases for Hypokalemia:

Name: Hypokalemia 12 77 30 56 6 15
Potassium Deficiency 77 17 74
Potassium Deficiency Disorder 12 74
Hypopotassemia 12
Potassium 44

Classifications:

MalaCards categories:
Global: Metabolic diseases
Anatomical: Blood diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:4500
NCIt 51 C34939
ICD10 34 E87.6
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Summaries for Hypokalemia

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MedlinePlus : 44 Potassium is a mineral that your body needs to work properly. It is a type of electrolyte. It helps your nerves to function and muscles to contract. It helps your heartbeat stay regular. It also helps move nutrients into cells and waste products out of cells. A diet rich in potassium helps to offset some of sodium's harmful effects on blood pressure. Many people get all the potassium they need from what they eat and drink. Sources of potassium in the diet include Leafy greens, such as spinach and collards Fruit from vines, such as grapes and blackberries Root vegetables, such as carrots and potatoes Citrus fruits, such as oranges and grapefruit Your kidneys help to keep the right amount of potassium in your body. If you have chronic kidney disease, your kidneys may not remove extra potassium from the blood. Some medicines also can raise your potassium level. You may need a special diet to lower the amount of potassium that you eat.

MalaCards based summary : Hypokalemia, also known as potassium deficiency, is related to apparent mineralocorticoid excess and diabetes insipidus, nephrogenic, autosomal. An important gene associated with Hypokalemia is SLC12A3 (Solute Carrier Family 12 Member 3), and among its related pathways/superpathways are Peptide hormone metabolism and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The drugs Dopamine and Furosemide have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and lung, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 77 Hypokalemia is a low level of potassium (K+) in the blood serum. Mildly low levels do not typically... more...

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Related Diseases for Hypokalemia

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Diseases related to Hypokalemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 915)
# Related Disease Score Top Affiliating Genes
1 apparent mineralocorticoid excess 32.5 HSD11B2 NR3C2 REN
2 diabetes insipidus, nephrogenic, autosomal 32.1 AQP2 CASR SLC12A1
3 liddle syndrome 1 31.9 HSD11B2 NR3C2 REN
4 seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance 31.8 AQP2 KCNJ1 SLC12A3
5 gitelman syndrome 31.4 BSND CASR CLCNKB KCNJ1 REN SLC12A1
6 bartter syndrome, type 2, antenatal 31.2 CASR KCNJ1 NR3C2
7 pseudohyperkalemia, familial, 2, due to red cell leak 31.2 ACE KCNJ1 NR3C2 REN
8 hyperaldosteronism, familial, type i 31.2 HSD11B2 NR3C2 POMC REN
9 bartter disease 30.7 BSND CASR CLCNKB KCNJ1 REN SLC12A1
10 adenoma 30.4 CASR HSD11B2 POMC
11 bartter syndrome, type 3 30.2 BSND CLCNKB KCNJ1 REN SLC12A1 SLC12A3
12 conn's syndrome 30.2 HSD11B2 NR3C2 POMC REN
13 renal hypertension 30.0 ACE REN SLC12A3
14 hypoaldosteronism 29.8 ACE POMC REN
15 inappropriate adh syndrome 29.7 AQP2 POMC REN
16 chondrocalcinosis 29.7 CASR SLC12A3
17 fibromuscular dysplasia 29.7 ACE REN
18 chronic kidney failure 29.7 ACE CASR REN
19 premenstrual tension 29.6 POMC REN
20 renovascular hypertension 29.6 ACE REN
21 congestive heart failure 29.5 ACE NR3C2 REN
22 anuria 29.5 ACE HSD11B2 NR3C2 REN
23 polycystic kidney disease 29.5 ACE AQP2 REN
24 hypertension, diastolic 29.4 ACE REN
25 syndrome of inappropriate antidiuretic hormone 29.4 ACE AQP2 POMC
26 diabetes insipidus 29.4 AQP2 POMC REN SLC12A1
27 autosomal dominant polycystic kidney disease 29.4 ACE AQP2 REN
28 familial hypertension 29.3 HSD11B2 NR3C2 REN
29 kidney disease 29.3 ACE AQP2 CASR NR3C2 REN
30 pseudohypoaldosteronism 29.3 KCNJ1 NR3C2 REN SLC12A3
31 aortic valve disease 1 29.1 ACE POMC REN
32 systolic heart failure 29.0 ACE NR3C2
33 hypertension, essential 29.0 ACE HSD11B2 NR3C2 REN SLC12A1 SLC12A3
34 nephrocalcinosis 28.9 CASR CLCNKB HSD11B2 KCNJ1 SLC12A1 SLC12A3
35 body mass index quantitative trait locus 11 28.7 HSD11B2 KCNH2 NR3C2 POMC
36 nephrolithiasis 28.7 BSND CASR CLCNKB KCNJ1 SLC12A1
37 myotonia, potassium-aggravated 12.7
38 potassium dichromate allergic contact dermatitis 12.3
39 hypertensive hypokalemia familial 12.1
40 sodium-potassium-atpase activity of red cell 12.1
41 hyperkalemic periodic paralysis 12.0
42 normokalemic periodic paralysis 12.0
43 andersen cardiodysrhythmic periodic paralysis 12.0
44 vipoma 11.9
45 wdha syndrome 11.9
46 overhydrated hereditary stomatocytosis 11.6
47 thyrotoxic periodic paralysis 11.6
48 renal tubular acidosis, distal 11.6
49 thyrotoxic periodic paralysis 1 11.5
50 pancreatic cholera 11.4

Graphical network of the top 20 diseases related to Hypokalemia:



Diseases related to Hypokalemia
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Symptoms & Phenotypes for Hypokalemia

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MGI Mouse Phenotypes related to Hypokalemia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.17 ACE AQP2 BSND CACNA1S CASR HSD11B2
2 cardiovascular system MP:0005385 10.14 ACE BSND CACNA1S HSD11B2 KCNH2 KCNJ1
3 growth/size/body region MP:0005378 10.11 ACE AQP2 BSND CACNA1S CASR KCNH2
4 homeostasis/metabolism MP:0005376 10.1 ACE AQP2 BSND CACNA1S CASR CLCNKB
5 hematopoietic system MP:0005397 9.97 ACE AQP2 BSND CASR KCNJ1 NR3C2
6 mortality/aging MP:0010768 9.93 ACE AQP2 BSND CACNA1S CASR HSD11B2
7 muscle MP:0005369 9.43 CACNA1S CASR HSD11B2 KCNH2 NR3C2 REN
8 renal/urinary system MP:0005367 9.4 ACE AQP2 BSND CASR CLCNKB HSD11B2
Sources

Drugs & Therapeutics for Hypokalemia

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Drugs for Hypokalemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 402)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
2
Furosemide Approved, Vet_approved Phase 4,Phase 2,Phase 1,Early Phase 1 54-31-9 3440
3
Progesterone Approved, Vet_approved Phase 4,Phase 2 57-83-0 5994
4
Mifepristone Approved, Investigational Phase 4 84371-65-3 55245
5
Licorice Approved Phase 4
6
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 58-93-5 3639
7
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 22916-47-8 4189
8
Amphotericin B Approved, Investigational Phase 4,Phase 2 1397-89-3 14956 5280965
9
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
10
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
11
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
12
Acetaminophen Approved Phase 4 103-90-2 1983
13
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-03-3
14
Procaterol Approved, Investigational Phase 4 72332-33-3 688561
15
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-23-7 5754
16
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
17
Chlorothiazide Approved, Vet_approved Phase 4 58-94-6 2720
18
Metolazone Approved Phase 4 17560-51-9 4170
19
Tolvaptan Approved Phase 4 150683-30-0 216237
20
Entecavir Approved, Investigational Phase 4,Phase 3,Phase 2 142217-69-4 153941
21
Insulin glargine Approved Phase 4 160337-95-1
22
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 7440-66-6 32051
23
Spironolactone Approved Phase 4,Phase 2,Phase 3,Not Applicable 52-01-7, 1952-01-7 5833
24
tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1401-55-4
25
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
26
Chlorthalidone Approved Phase 4,Phase 3,Phase 2,Not Applicable 77-36-1 2732
27 Dopamine Agents Phase 4
28 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
29 Natriuretic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
30 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Sodium Potassium Chloride Symporter Inhibitors Phase 4,Phase 2,Phase 1,Early Phase 1
33 Sympathomimetics Phase 4,Phase 3,Phase 2
34 Cardiotonic Agents Phase 4,Phase 2
35 diuretics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
36 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1
37 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
38 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Adrenergic beta-2 Receptor Agonists Phase 4,Phase 1,Not Applicable
40 Albuterol Phase 4,Phase 2,Not Applicable
41 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Tocolytic Agents Phase 4,Phase 1,Phase 2,Not Applicable
44 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Respiratory System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
46 Bronchodilator Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Not Applicable
48 insulin Phase 4,Phase 3,Phase 2,Not Applicable
49 Insulin, Globin Zinc Phase 4,Phase 3,Phase 2,Not Applicable
50 Sodium Chloride Symporter Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 171)
# Name Status NCT ID Phase Drugs
1 Comparison of Enteral Versus Intravenous Potassium Supplementation Unknown status NCT02015962 Phase 4 Intravenous potassium chloride;Oral potassium chloride
2 Efficacy of KCl Plus 0.9%NaCl Compare With KCl Plus 0.45%NaCl Unknown status NCT02721095 Phase 4
3 The Effect of a Diet Based on Low Sodium and Slowly Absorbed Carbohydrates on the Incidence of Refeeding Syndrome in Patients With Head and Neck Cancer Unknown status NCT01845922 Phase 4
4 Dopamine in Acute Decompensated Heart Failure (DAD-HF) Trial Unknown status NCT00937092 Phase 4 Furosemide;low-dose dopamine + low-dose furosemide
5 Monocentric STUDY, Randomised Double Blinded (Healthy Subjects, or Transversal (Patients With Gitelman Syndrome) Completed NCT02297048 Phase 4
6 Effect of Licorice and Hydrochlorothiazide on Plasma Potassium Completed NCT00605202 Phase 4 Hydrochlorothiazide
7 Safety of Continuous Potassium Chloride Infusion in Critical Care Completed NCT00718068 Phase 4 Sterile Potassium Chloride Concentrate;Sterile Potassium Chloride Concentrate
8 Safety and Effectiveness of Short-course AmBisome in the Treatment of PKDL in Bangladesh Completed NCT03311607 Phase 4 AmBisome
9 Miralax (PEG 3350) vs. Golytely as Bowel Preparation for Screening Colonoscopy Completed NCT01170754 Phase 4 PEG-3350 and Gatorade;Golytely 4 liters
10 Early Diuresis Following Colorectal Surgery Completed NCT02351934 Phase 4 Furosemide;Celecoxib;Gabapentin
11 Comparative Study on the Efficacy and Safety of Procaterol Versus Salbutamol Given Via Metered Dose Inhaler With Spacer in the Management of Acute Asthma Attack in the Emergency Room Completed NCT01091337 Phase 4 Procaterol;Salbutamol
12 Potassium Infusion for Conversion of Atrial Fibrillation/-Flutter Completed NCT01818583 Phase 4 Potassium chloride;Glucose 50 MG/ML
13 Blood Pressure Regulation - Role of Potassium Completed NCT02380157 Phase 4 Kaleorid, 750mg (trade name), Potassium chloride (active substance);Placebo
14 Efficacy of Sodium Polystyrene Sulfonate in the Treatment of Hyperkaliemia in Pre-dialysis Patients Completed NCT02065076 Phase 4 Sodium polystyrene sulfonate;Lactose with carob gum
15 Metabolism of Isotonic Versus Hypotonic Maintenance Solutions in Fasting Healthy Adults Completed NCT02822898 Phase 4 NaCl 0.9% in Glucose 5% with 40mEq Potassium;Glucion 5%
16 Diuretics for Postpartum High Blood Pressure in Preeclampsia Completed NCT02163655 Phase 4 FUROSEMIDE;Placebo
17 A Longitudinal 2-year Bone Marrow Study of Eltrombopag in Previously Treated Adults, With Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Completed NCT01098487 Phase 4 Eltrombopag olamine
18 Comparison of Oral or Intravenous Thiazides vs Tolvaptan in Diuretic Resistant Decompensated Heart Failure Completed NCT02606253 Phase 4 tolvaptan;Chlorothiazide;Metolazone
19 Diuretics In the Management of Essential Hypertension (DIME) Study Completed NCT00131846 Phase 4 Thiazide diuretics;No diuretics
20 PROPHYSOME: Pilot Study on Safety of a Weekly Administration of 10mg/kg of AmBisome® in Antifungal Prophylaxis Treatment of Allogeneic Stem-cell Transplantation and Acute Leukaemia Completed NCT00362544 Phase 4 Ambisome
21 Effect of Entecavir in Blacks/African Americans and Hispanics With Chronic Hepatitis B Virus (HBV) Infection Completed NCT00371150 Phase 4 Entecavir
22 Insulin in Total Parenteral Nutrition Completed NCT02706119 Phase 4 Subcutaneous glargine insulin;Regular insulin added to TPN bag
23 Intravenous Fluids in Hospitalised Children Recruiting NCT02926989 Phase 4 Plasmalyte Glucos 50 mg/mL;0.45% saline in 5% dextrose
24 Diuretic Effect of Metolazone Pre-dosing Versus Concurrent Dosing Recruiting NCT03746002 Phase 4 Metolazone 60 minutes prior to furosemide;Metolazone concurrently with furosemide
25 The Impact of Neut During Potassium Chloride Replacement on Pain and Incidence of Phlebitis Enrolling by invitation NCT02082717 Phase 4 potassium chloride replacement;Experimental - 4% Sodium Bicarbonate
26 Prospective Comparison of Metolazone Versus Chlorothiazide for Acute Decompensated Heart Failure With Diuretic Resistance Enrolling by invitation NCT03574857 Phase 4 Metolazone Oral Tablet;Chlorothiazide Injection
27 Targeted Potassium Levels for Prevention of ICD Therapy Not yet recruiting NCT03833089 Phase 4
28 Protocol of Diuretics Use in Congestive Therapy in Heart Failure Not yet recruiting NCT03892148 Phase 4 Furosemide;Hydrochlorothiazide
29 Use of Spironolactone for the Prevention of Electrolyte Abnormalities in Patients Treated With Amphotericin B Terminated NCT01843309 Phase 4 Spironolactone 100mg;Spironolactone 200mg;Placebo
30 Dopamine in Acute Decompensated Heart Failure II Terminated NCT01060293 Phase 4 High-dose furosemide;Low-dose furosemide;Low-dose furosemide combined with low-dose dopamine
31 Protocolized Diuretic Strategy in Cardiorenal Failure Terminated NCT01921829 Phase 4 Protocolized Diuretic Strategy
32 Tight Intra-Operative Glucose Control During Coronary Artery Bypass Surgery Terminated NCT00394303 Phase 4 Intraoperative continuous insulin infusion
33 ACTHAR GEL in Patients With Membranous (Class V) Lupus Nephritis Withdrawn NCT01926054 Phase 4 Acthar gel
34 The Management of Resistant Hypertension in Kidney Transplant Patients Using Chlorthalidone Withdrawn NCT02030314 Phase 4 Chlorthalidone
35 Preventing Acute Renal Failure After Cardiac Surgery in High Risk Patients Using Sodium Bicarbonate Therapy Unknown status NCT00522756 Phase 3 Sodium bicarbonate;Sodium chloride
36 Irbesartan/Hydrochlorothiazide (HCTZ) Combination Therapy for Patients With Moderate Hypertension Completed NCT00095550 Phase 3 Irbesartan/HCTZ;Irbesartan monotherapy;HCTZ monotherapy
37 Irbesartan/Hydrochlorothiazide (HCTZ) Combination Therapy as First Line Treatment for Severe Hypertension Completed NCT00095394 Phase 3 Irbesartan/HCTZ;Irbesartan monotherapy
38 Hypertension Prevention in Pre-Hypertensive Individuals Completed NCT00970931 Phase 3 Chlorthalidone plus amiloride;placebo
39 Diuretics and Angiotensin-Receptor Blocker Agents in Patients With Stage I Hypertension Completed NCT00971165 Phase 3 losartan;Chlorthalidone plus amiloride
40 SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan. Completed NCT01096654 Phase 3
41 Vitamin K2 Supplementation to Activate Matrix Gla Protein (MGP) as Endogenous Inhibitor of Vascular Calcification in Hemodialysis Patients Completed NCT01407601 Phase 3
42 Heart And Lung Failure - Pediatric INsulin Titration Trial Completed NCT01565941 Phase 3 Insulin;Insulin
43 Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Primary Central Nervous System (CNS) Germ Cell Tumor Completed NCT00085098 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
44 Pazopanib Versus Placebo in Patients With Soft Tissue Sarcoma Whose Disease Has Progressed During or Following Prior Therapy Completed NCT00753688 Phase 3 PAZOPANIB;Placebo
45 Effect of Vitamin K on Age-Related Bone Loss and Vascular Calcification Completed NCT00183001 Phase 3 Vitamin K
46 Renin-angiotensin-aldosterone System (RAAS), Inflammation, and Post-Operative Atrial Fibrillation (AF) Completed NCT00141778 Phase 2, Phase 3 Placebo;Ramipril;Spironolactone
47 BMS-Reyataz Study in Treatment in Naive Subjects to Compare the Efficacy and Safety Between Boosted Reyataz and Kaletra When in Combination With Fixed Dose Truvada Completed NCT00272779 Phase 3 ATV;RTV;Tenofovi-Emtricitabine (TDF/FTC) tablet;LPV
48 Safety and Quality of Life Study of Aflibercept in Patients With Metastatic Colorectal Cancer Previously Treated With an Oxaliplatin-Based Regimen Completed NCT01571284 Phase 3 AFLIBERCEPT AVE0005;FOLFIRI
49 Extension Study to VEG105192 to Assess Pazopanib in Patients With Advanced/Metastatic Renal Cell Cancer Completed NCT00387764 Phase 3 pazopanib
50 Axitinib (AG 013736) As Second Line Therapy For Metastatic Renal Cell Cancer Completed NCT00678392 Phase 3 Axitinib (AG-013736);Sorafenib

Search NIH Clinical Center for Hypokalemia

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Genetic Tests for Hypokalemia

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Genetic tests related to Hypokalemia:

# Genetic test Affiliating Genes
1 Hypokalemia 30
Sources

Anatomical Context for Hypokalemia

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MalaCards organs/tissues related to Hypokalemia:

42
Heart, Kidney, Lung, Prostate, Liver, Myeloid, Breast
Sources

Publications for Hypokalemia

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Articles related to Hypokalemia:

(show top 50) (show all 1550)
# Title Authors Year
1
Hyperglycemia and Hypokalemia in a 16-Year-Old Overweight Female Patient Misdiagnosed with Cushing Syndrome at First and Ultimately Diagnosed with Carney Complex Proven by PRKAR1A Gene Test: a Case Report and Literature Review. ( 30868845 )
2019
2
Association between hypokalemia and small bowel capsule endoscopy completion rates in patients in South China: A prospective single-center study. ( 30479322 )
2019
3
Patients with hypokalemia develop WNK bodies in the distal convoluted tubule of the kidney. ( 30484345 )
2019
4
Recurrent seizure-triggered Takotsubo associated with hypokalemia and hypomagnesemia. ( 30581151 )
2019
5
One more reason to avoid purgatives before capsule endoscopy examinations: Hypokalemia and low completion rates. ( 30638188 )
2019
6
Intractable Hypokalemia: a Red Herring for Rapidly Evolving Ectopic Cushing's Syndrome. ( 30685911 )
2019
7
Development and validation of a dynamic inpatient risk prediction model for clinically significant hypokalemia using electronic health record data. ( 30698650 )
2019
8
Atg7-dependent canonical autophagy regulates the degradation of aquaporin 2 in prolonged hypokalemia. ( 30816234 )
2019
9
TRPV4 deletion protects against hypokalemia during systemic K+ deficiency. ( 30838874 )
2019
10
Physiological Analysis and Proteome Quantification of Alligator Weed Stems in Response to Potassium Deficiency Stress. ( 30626112 )
2019
11
The Cotton High-affinity K+ Transporter, GhHAK5a, is Essential for Shoot Regulation of K+ Uptake in Root under Potassium Deficiency. ( 30649443 )
2019
12
Genetic screening for Bartter syndrome and Gitelman syndrome pathogenic genes among individuals with hypertension and hypokalemia. ( 29953267 )
2018
13
Effects of antiarrhythmics and hypokalemia on the rate adaptation of cardiac repolarization. ( 29798684 )
2018
14
Potential Usefulness of Early Potassium Supplementation for Preventing Severe Hypokalemia Induced by Liposomal Amphotericin B in Hematologic Patients: A Retrospective Study. ( 29305017 )
2018
15
Hypokalemia: a clinical update. ( 29540487 )
2018
16
Nafcillin-Associated Hypokalemia. ( 29672332 )
2018
17
Regional anesthesia is safe and effective for lower limb orthopedic surgery in patient with renal tubular acidosis and hypokalemia. ( 29643635 )
2018
18
Chest pain as a manifestation of hypokalemia in a pediatric patient. ( 29126579 )
2018
19
Prognostic Impact of Mild Hypokalemia in Terms of Death and Stroke in the General Population-A Prospective Population Study. ( 29024624 )
2018
20
ECG Changes of Severe Hypokalemia. ( 29490087 )
2018
21
Refractory Hypokalemia from Syndrome of Apparent Mineralocorticoid Excess on Low-Dose Posaconazole. ( 29661880 )
2018
22
Clinical characterization and diagnosis of cystic fibrosis through exome sequencing in Chinese infants with Bartter-syndrome-like hypokalemia alkalosis. ( 29520692 )
2018
23
Hypokalemia in an end stage renal disease patient. ( 29842873 )
2018
24
Comments on the Prognostic Impact of Mild Hypokalemia. ( 29555045 )
2018
25
First-Episode Psychosis and Hypokalemia: A Case Report and Review of the Literature. ( 29944416 )
2018
26
Hypokalemia associated with pseudo-Cushing's syndrome and magnesium deficiency induced by chronic alcohol abuse. ( 29450857 )
2018
27
Itraconazole induced hypertension and hypokalemia: Mechanistic evaluation. ( 29385285 )
2018
28
A Young Patient with Leg Weakness and Hypokalemia-Case Report. ( 29514039 )
2018
29
A rare case of hypokalemia-induced rhabdomyolysis. ( 29915623 )
2018
30
Incident Hyperkalemia, Hypokalemia, and Clinical Outcomes During Spironolactone Treatment of Heart Failure With Preserved Ejection Fraction: Analysis of the TOPCAT Trial. ( 29572190 )
2018
31
Protection against severe hypokalemia but impaired cardiac repolarization after intense rowing exercise in healthy humans receiving salbutamol. ( 29745804 )
2018
32
Hypokalemia ( 29494072 )
2018
33
An initial evaluation of hypokalemia turned out distal renal tubular acidosis secondary to parathyroid adenoma. ( 30381523 )
2018
34
Severe hypokalemia with cardiac arrest as an unusual manifestation of alcoholism. ( 30357049 )
2018
35
The Case | Severe hypokalemia and metabolic acidosis. ( 29680030 )
2018
36
The Case | Severe hypokalemia complicated by a syncope. ( 29933854 )
2018
37
Prolonged attacks of weakness with hypokalemia in SCN4A-related paramyotonia congenita. ( 30028520 )
2018
38
Refractory hypokalemia while weaning off bypass. ( 30052224 )
2018
39
Ibuprofen Abuse-A Case of Rhabdomyolysis, Hypokalemia, and Hypophosphatemia With Drug-Induced Mixed Renal Tubular Acidosis. ( 30197993 )
2018
40
Posaconazole-induced hypertension and hypokalemia due to inhibition of the 11β-hydroxylase enzyme. ( 30289132 )
2018
41
Severe Hypokalemia Mimicking Brain Death. ( 30294136 )
2018
42
Serious Hypokalemia Associated with Abiraterone Acetate in Patients with Castration-Resistant Prostate Cancer. ( 30305978 )
2018
43
Prevalence and risk factors for hypokalemia in patients scheduled for laparoscopic colorectal resection and its association with post-operative recovery. ( 30340534 )
2018
44
A case of hypokalemia and proteinuria with a new mutation in the SLC12A3 Gene. ( 30340552 )
2018
45
Prognostic Utility of Hypokalemia in Cirrhotic Patients. ( 30350528 )
2018
46
Oral acyclovir induced hypokalemia and acute tubular necrosis a case report. ( 30428841 )
2018
47
Hypokalemia-Induced Arrhythmias and Heart Failure: New Insights and Implications for Therapy. ( 30464746 )
2018
48
Hypokalemia Associated With a Claudin 10 Mutation: A Case Report. ( 30482581 )
2018
49
Primary biliary cirrhosis with refractory hypokalemia: A case report. ( 30508897 )
2018
50
Electrocardiographic manifestations in severe hypokalemia. ( 30509119 )
2018
Sources

Variations for Hypokalemia

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ClinVar genetic disease variations for Hypokalemia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SLC12A3 NM_000339.2(SLC12A3): c.2221G> A (p.Gly741Arg) single nucleotide variant Conflicting interpretations of pathogenicity rs138977195 GRCh37 Chromosome 16, 56921879: 56921879
2 SLC12A3 NM_000339.2(SLC12A3): c.2221G> A (p.Gly741Arg) single nucleotide variant Conflicting interpretations of pathogenicity rs138977195 GRCh38 Chromosome 16, 56887967: 56887967
3 SLC12A3 NM_000339.2(SLC12A3): c.457G> A (p.Val153Met) single nucleotide variant Uncertain significance rs779074538 GRCh37 Chromosome 16, 56902236: 56902236
4 SLC12A3 NM_000339.2(SLC12A3): c.457G> A (p.Val153Met) single nucleotide variant Uncertain significance rs779074538 GRCh38 Chromosome 16, 56868324: 56868324
Sources

Expression for Hypokalemia

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Search GEO for disease gene expression data for Hypokalemia.
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Pathways for Hypokalemia

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Pathways related to Hypokalemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Peptide hormone metabolism 67
Show member pathways
 11.76 ACE POMC REN
2
Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics 62
Show member pathways
 11.34 ACE NR3C2 REN
3
Renin secretion 38
11.17 ACE CACNA1S REN
4
Aldosterone-regulated sodium reabsorption 38
10.7 HSD11B2 KCNJ1 NR3C2
5
Diuretics Pathway, Pharmacodynamics 62
10.48 BSND CLCNKB KCNJ1 SLC12A1 SLC12A3
Sources

GO Terms for Hypokalemia

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Cellular components related to Hypokalemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.9 ACE AQP2 BSND CACNA1S CASR CLCNKB
2 plasma membrane GO:0005886 9.7 ACE AQP2 BSND CACNA1S CASR CLCNKB
3 apical plasma membrane GO:0016324 9.56 AQP2 CASR SLC12A1 SLC12A3
4 basolateral plasma membrane GO:0016323 9.5 AQP2 BSND CASR
5 membrane GO:0016020 9.44 ACE AQP2 BSND CACNA1S CASR CLCNKB

Biological processes related to Hypokalemia according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 ion transmembrane transport GO:0034220 9.76 BSND CLCNKB KCNJ1 SLC12A1
2 ion transport GO:0006811 9.73 CACNA1S CLCNKB KCNH2 KCNJ1 SLC12A1 SLC12A3
3 potassium ion transport GO:0006813 9.7 KCNH2 KCNJ1 SLC12A1
4 regulation of ion transmembrane transport GO:0034765 9.67 CACNA1S CLCNKB KCNH2 KCNJ1
5 transmembrane transport GO:0055085 9.63 AQP2 CACNA1S CLCNKB KCNH2 SLC12A1 SLC12A3
6 regulation of blood pressure GO:0008217 9.61 ACE POMC REN
7 potassium ion import across plasma membrane GO:1990573 9.58 KCNJ1 SLC12A1 SLC12A3
8 calcium ion import GO:0070509 9.55 CACNA1S CASR
9 cell volume homeostasis GO:0006884 9.54 SLC12A1 SLC12A3
10 amyloid-beta metabolic process GO:0050435 9.51 ACE REN
11 excretion GO:0007588 9.5 AQP2 CLCNKB KCNJ1
12 angiotensin maturation GO:0002003 9.49 ACE REN
13 chloride ion homeostasis GO:0055064 9.48 SLC12A1 SLC12A3
14 potassium ion homeostasis GO:0055075 9.13 KCNH2 SLC12A1 SLC12A3
15 chloride transmembrane transport GO:1902476 9.02 BSND CASR CLCNKB SLC12A1 SLC12A3

Molecular functions related to Hypokalemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.58 CACNA1S KCNH2 KCNJ1
2 steroid binding GO:0005496 9.46 HSD11B2 NR3C2
3 inward rectifier potassium channel activity GO:0005242 9.43 KCNH2 KCNJ1
4 potassium:chloride symporter activity GO:0015379 9.32 SLC12A1 SLC12A3
5 cation:chloride symporter activity GO:0015377 9.26 SLC12A1 SLC12A3
6 sodium ion transmembrane transporter activity GO:0015081 9.16 SLC12A1 SLC12A3
7 voltage-gated chloride channel activity GO:0005247 9.07 CLCNKB
8 sodium:chloride symporter activity GO:0015378 8.96 SLC12A1 SLC12A3
9 sodium:potassium:chloride symporter activity GO:0008511 8.62 SLC12A1 SLC12A3
Sources

Sources for Hypokalemia

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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