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MCID: HYP005
MIFTS: 55

Hypokalemia

Categories: Blood diseases, Metabolic diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Hypokalemia

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MalaCards integrated aliases for Hypokalemia:

Name: Hypokalemia 12 76 29 55 6 15
Potassium Deficiency Disorder 12 73
Potassium Deficiency 76 73
Hypopotassemia 12
Potassium 43

Classifications:

MalaCards categories:
Global: Metabolic diseases
Anatomical: Blood diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:4500
NCIt 50 C34939
ICD10 33 E87.6
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Summaries for Hypokalemia

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MedlinePlus : 43 Potassium is a mineral that your body needs to work properly. It is a type of electrolyte. It helps your nerves to function and muscles to contract. It helps your heartbeat stay regular. It also helps move nutrients into cells and waste products out of cells. A diet rich in potassium helps to offset some of sodium's harmful effects on blood pressure. Many people get all the potassium they need from what they eat and drink. Sources of potassium in the diet include Leafy greens, such as spinach and collards Fruit from vines, such as grapes and blackberries Root vegetables, such as carrots and potatoes Citrus fruits, such as oranges and grapefruit Your kidneys help to keep the right amount of potassium in your body. If you have chronic kidney disease, your kidneys may not remove extra potassium from the blood. Some medicines also can raise your potassium level. You may need a special diet to lower the amount of potassium that you eat.

MalaCards based summary : Hypokalemia, also known as potassium deficiency disorder, is related to apparent mineralocorticoid excess and gitelman syndrome. An important gene associated with Hypokalemia is SLC12A3 (Solute Carrier Family 12 Member 3), and among its related pathways/superpathways are Peptide hormone metabolism and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The drugs Furosemide and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and liver, and related phenotypes are cardiovascular system and behavior/neurological

Wikipedia : 76 Hypokalemia, also spelled hypokalaemia, is a low level of potassium (K+) in the blood serum. Mildly low... more...

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Related Diseases for Hypokalemia

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Diseases related to Hypokalemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 819)
# Related Disease Score Top Affiliating Genes
1 apparent mineralocorticoid excess 32.3 HSD11B2 NR3C1 NR3C2 REN
2 gitelman syndrome 32.1 BSND CLCNKB KCNJ1 REN SLC12A1 SLC12A3
3 seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance 31.7 AQP2 KCNJ1 SLC12A3
4 liddle syndrome 1 31.6 HSD11B2 NR3C1 NR3C2 REN
5 pseudohyperkalemia, familial, 2, due to red cell leak 31.4 ACE KCNJ1 NR3C2 REN
6 bartter syndrome, type 2, antenatal 31.4 KCNJ1 NR3C2
7 bartter disease 31.4 BSND CLCNKB KCNJ1 REN SLC12A1 SLC12A3
8 hyperaldosteronism, familial, type i 31.0 HSD11B2 NR3C1 NR3C2 POMC REN
9 bartter syndrome, type 3 30.6 BSND CLCNKB KCNJ1 REN SLC12A1 SLC12A3
10 conn's syndrome 30.0 HSD11B2 NR3C1 NR3C2 POMC REN
11 renal hypertension 29.9 ACE REN SLC12A3
12 malignant hypertension 29.8 ACE REN
13 hypoaldosteronism 29.8 ACE POMC REN
14 hyporeninemic hypoaldosteronism 29.7 ACE REN
15 anuria 29.6 ACE HSD11B2 NR3C2 REN
16 inappropriate adh syndrome 29.6 AQP2 POMC REN
17 congestive heart failure 29.6 ACE NR3C2 REN
18 fibromuscular dysplasia 29.6 ACE REN
19 kidney disease 29.5 ACE AQP2 NR3C2 REN
20 syndrome of inappropriate antidiuretic hormone 29.5 ACE AQP2 POMC
21 polycystic kidney disease 29.5 ACE AQP2 REN
22 diabetes insipidus 29.4 AQP2 POMC REN SLC12A1
23 nephrocalcinosis 29.4 CLCNKB HSD11B2 KCNJ1 SLC12A1 SLC12A3
24 hypertension, diastolic 29.4 ACE REN
25 premenstrual tension 29.3 POMC REN
26 pseudohypoaldosteronism 29.3 KCNJ1 NR3C2 REN SLC12A3
27 familial hypertension 29.3 HSD11B2 NR3C2 REN
28 nephrolithiasis 29.2 BSND CLCNKB KCNJ1 SLC12A1
29 renovascular hypertension 29.2 ACE REN
30 autosomal dominant polycystic kidney disease 29.2 ACE AQP2 REN
31 systolic heart failure 29.1 ACE NR3C2
32 hypertension, essential 28.8 ACE HSD11B2 NR3C1 NR3C2 POMC REN
33 myotonia, potassium-aggravated 12.6
34 potassium dichromate allergic contact dermatitis 12.2
35 hypertensive hypokalemia familial 12.1
36 sodium-potassium-atpase activity of red cell 12.0
37 hyperkalemic periodic paralysis 12.0
38 normokalemic periodic paralysis 12.0
39 andersen cardiodysrhythmic periodic paralysis 12.0
40 vipoma 11.9
41 wdha syndrome 11.8
42 overhydrated hereditary stomatocytosis 11.6
43 thyrotoxic periodic paralysis 11.5
44 renal tubular acidosis, distal 11.5
45 thyrotoxic periodic paralysis 1 11.5
46 pancreatic cholera 11.4
47 episodic ataxia 11.3
48 epilepsy, progressive myoclonic 7 11.3
49 benign familial neonatal epilepsy 11.3
50 periodic paralyses 11.3

Graphical network of the top 20 diseases related to Hypokalemia:



Diseases related to Hypokalemia
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Symptoms & Phenotypes for Hypokalemia

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MGI Mouse Phenotypes related to Hypokalemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.18 ACE BSND CACNA1S HSD11B2 KCNH2 KCNJ1
2 behavior/neurological MP:0005386 10.17 ACE AQP2 BSND CACNA1S HSD11B2 KCNJ1
3 growth/size/body region MP:0005378 10.11 ACE AQP2 BSND CACNA1S KCNH2 KCNJ1
4 homeostasis/metabolism MP:0005376 10.1 ACE AQP2 BSND CACNA1S CLCNKB HSD11B2
5 hematopoietic system MP:0005397 9.97 ACE AQP2 BSND KCNJ1 NR3C1 NR3C2
6 mortality/aging MP:0010768 9.93 ACE AQP2 BSND CACNA1S HSD11B2 KCNH2
7 muscle MP:0005369 9.43 CACNA1S HSD11B2 KCNH2 NR3C1 NR3C2 REN
8 renal/urinary system MP:0005367 9.4 ACE AQP2 BSND CLCNKB HSD11B2 KCNJ1
Sources

Drugs & Therapeutics for Hypokalemia

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Drugs for Hypokalemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 349)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Furosemide Approved, Vet_approved Phase 4,Phase 2,Phase 1,Early Phase 1 54-31-9 3440
2
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
3
Progesterone Approved, Vet_approved Phase 4,Phase 2 57-83-0 5994
4
Mifepristone Approved, Investigational Phase 4 84371-65-3 55245
5
Licorice Approved Phase 4
6
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 58-93-5 3639
7
Amphotericin B Approved, Investigational Phase 4,Phase 2 1397-89-3 5280965 14956
8
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 22916-47-8 4189
9
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
10
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
11
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
12
Acetaminophen Approved Phase 4 103-90-2 1983
13
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-23-7 5754
14
Procaterol Approved, Investigational Phase 4 72332-33-3 688561
15
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-03-3
16
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
17
Chlorothiazide Approved, Vet_approved Phase 4 58-94-6 2720
18
Metolazone Approved Phase 4 17560-51-9 4170
19
Tolvaptan Approved Phase 4 150683-30-0 216237
20
Entecavir Approved, Investigational Phase 4,Phase 3,Phase 2 142217-69-4 153941
21
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 7440-66-6
22
Insulin Glargine Approved Phase 4 160337-95-1
23
Spironolactone Approved Phase 4,Phase 2,Phase 3,Not Applicable 52-01-7, 1952-01-7 5833
24 tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
26
Chlorthalidone Approved Phase 4,Phase 3,Phase 2,Not Applicable 77-36-1 2732
27 diuretics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
28 Sympathomimetics Phase 4,Phase 3,Phase 2
29 Sodium Potassium Chloride Symporter Inhibitors Phase 4,Phase 2,Phase 1,Early Phase 1
30 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
31 Dopamine Agents Phase 4
32 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 Cardiotonic Agents Phase 4,Phase 2
34 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1
35 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Natriuretic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
37 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
38 Albuterol Phase 4,Phase 2,Not Applicable
39 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
40 Tocolytic Agents Phase 4,Phase 1,Phase 2,Not Applicable
41 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Adrenergic beta-2 Receptor Agonists Phase 4,Phase 1,Not Applicable
43 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Bronchodilator Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Respiratory System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
47 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Not Applicable
48 insulin Phase 4,Phase 3,Phase 2,Not Applicable
49 Insulin, Globin Zinc Phase 4,Phase 3,Phase 2,Not Applicable
50 Sodium Chloride Symporter Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 160)
# Name Status NCT ID Phase Drugs
1 Comparison of Enteral Versus Intravenous Potassium Supplementation Unknown status NCT02015962 Phase 4 Intravenous potassium chloride;Oral potassium chloride
2 Efficacy of KCl Plus 0.9%NaCl Compare With KCl Plus 0.45%NaCl Unknown status NCT02721095 Phase 4
3 The Effect of a Diet Based on Low Sodium and Slowly Absorbed Carbohydrates on the Incidence of Refeeding Syndrome in Patients With Head and Neck Cancer Unknown status NCT01845922 Phase 4
4 Dopamine in Acute Decompensated Heart Failure (DAD-HF) Trial Unknown status NCT00937092 Phase 4 Furosemide;low-dose dopamine + low-dose furosemide
5 Monocentric STUDY, Randomised Double Blinded (Healthy Subjects, or Transversal (Patients With Gitelman Syndrome) Completed NCT02297048 Phase 4
6 Effect of Licorice and Hydrochlorothiazide on Plasma Potassium Completed NCT00605202 Phase 4 Hydrochlorothiazide
7 Safety of Continuous Potassium Chloride Infusion in Critical Care Completed NCT00718068 Phase 4 Sterile Potassium Chloride Concentrate;Sterile Potassium Chloride Concentrate
8 Safety and Effectiveness of Short-course AmBisome in the Treatment of PKDL in Bangladesh Completed NCT03311607 Phase 4 AmBisome
9 Miralax (PEG 3350) vs. Golytely as Bowel Preparation for Screening Colonoscopy Completed NCT01170754 Phase 4 PEG-3350 and Gatorade;Golytely 4 liters
10 Early Diuresis Following Colorectal Surgery Completed NCT02351934 Phase 4 Furosemide;Celecoxib;Gabapentin
11 Comparative Study on the Efficacy and Safety of Procaterol Versus Salbutamol Given Via Metered Dose Inhaler With Spacer in the Management of Acute Asthma Attack in the Emergency Room Completed NCT01091337 Phase 4 Procaterol;Salbutamol
12 Potassium Infusion for Conversion of Atrial Fibrillation/-Flutter Completed NCT01818583 Phase 4 Potassium chloride;Glucose 50 MG/ML
13 Blood Pressure Regulation - Role of Potassium Completed NCT02380157 Phase 4 Kaleorid, 750mg (trade name), Potassium chloride (active substance);Placebo
14 Efficacy of Sodium Polystyrene Sulfonate in the Treatment of Hyperkaliemia in Pre-dialysis Patients Completed NCT02065076 Phase 4 Sodium polystyrene sulfonate;Lactose with carob gum
15 Metabolism of Isotonic Versus Hypotonic Maintenance Solutions in Fasting Healthy Adults Completed NCT02822898 Phase 4 NaCl 0.9% in Glucose 5% with 40mEq Potassium;Glucion 5%
16 Diuretics for Postpartum High Blood Pressure in Preeclampsia Completed NCT02163655 Phase 4 FUROSEMIDE;Placebo
17 A Longitudinal 2-year Bone Marrow Study of Eltrombopag in Previously Treated Adults, With Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Completed NCT01098487 Phase 4 Eltrombopag olamine
18 Comparison of Oral or Intravenous Thiazides vs Tolvaptan in Diuretic Resistant Decompensated Heart Failure Completed NCT02606253 Phase 4 tolvaptan;Chlorothiazide;Metolazone
19 Diuretics In the Management of Essential Hypertension (DIME) Study Completed NCT00131846 Phase 4 Thiazide diuretics;No diuretics
20 PROPHYSOME: Pilot Study on Safety of a Weekly Administration of 10mg/kg of AmBisome® in Antifungal Prophylaxis Treatment of Allogeneic Stem-cell Transplantation and Acute Leukaemia Completed NCT00362544 Phase 4 Ambisome
21 Effect of Entecavir in Blacks/African Americans and Hispanics With Chronic Hepatitis B Virus (HBV) Infection Completed NCT00371150 Phase 4 Entecavir
22 Insulin in Total Parenteral Nutrition Completed NCT02706119 Phase 4 Subcutaneous glargine insulin;Regular insulin added to TPN bag
23 Intravenous Fluids in Hospitalised Children Recruiting NCT02926989 Phase 4 Plasmalyte Glucos 50 mg/mL;0.45% saline in 5% dextrose
24 The Impact of Neut During Potassium Chloride Replacement on Pain and Incidence of Phlebitis Enrolling by invitation NCT02082717 Phase 4 potassium chloride replacement;Experimental - 4% Sodium Bicarbonate
25 Prospective Comparison of Metolazone Versus Chlorothiazide for Acute Decompensated Heart Failure With Diuretic Resistance Enrolling by invitation NCT03574857 Phase 4 Metolazone Oral Tablet;Chlorothiazide Injection
26 Diuretic Effect of Metolazone Pre-dosing Versus Concurrent Dosing Not yet recruiting NCT03746002 Phase 4 Metolazone 60 minutes prior to furosemide;Metolazone concurrently with furosemide
27 Use of Spironolactone for the Prevention of Electrolyte Abnormalities in Patients Treated With Amphotericin B Terminated NCT01843309 Phase 4 Spironolactone 100mg;Spironolactone 200mg;Placebo
28 Dopamine in Acute Decompensated Heart Failure II Terminated NCT01060293 Phase 4 High-dose furosemide;Low-dose furosemide;Low-dose furosemide combined with low-dose dopamine
29 Protocolized Diuretic Strategy in Cardiorenal Failure Terminated NCT01921829 Phase 4 Protocolized Diuretic Strategy
30 Tight Intra-Operative Glucose Control During Coronary Artery Bypass Surgery Terminated NCT00394303 Phase 4 Intraoperative continuous insulin infusion
31 ACTHAR GEL in Patients With Membranous (Class V) Lupus Nephritis Withdrawn NCT01926054 Phase 4 Acthar gel
32 The Management of Resistant Hypertension in Kidney Transplant Patients Using Chlorthalidone Withdrawn NCT02030314 Phase 4 Chlorthalidone
33 Preventing Acute Renal Failure After Cardiac Surgery in High Risk Patients Using Sodium Bicarbonate Therapy Unknown status NCT00522756 Phase 3 Sodium bicarbonate;Sodium chloride
34 Irbesartan/Hydrochlorothiazide (HCTZ) Combination Therapy for Patients With Moderate Hypertension Completed NCT00095550 Phase 3 Irbesartan/HCTZ;Irbesartan monotherapy;HCTZ monotherapy
35 Irbesartan/Hydrochlorothiazide (HCTZ) Combination Therapy as First Line Treatment for Severe Hypertension Completed NCT00095394 Phase 3 Irbesartan/HCTZ;Irbesartan monotherapy
36 Hypertension Prevention in Pre-Hypertensive Individuals Completed NCT00970931 Phase 3 Chlorthalidone plus amiloride;placebo
37 Diuretics and Angiotensin-Receptor Blocker Agents in Patients With Stage I Hypertension Completed NCT00971165 Phase 3 losartan;Chlorthalidone plus amiloride
38 SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan. Completed NCT01096654 Phase 3
39 Vitamin K2 Supplementation to Activate Matrix Gla Protein (MGP) as Endogenous Inhibitor of Vascular Calcification in Hemodialysis Patients Completed NCT01407601 Phase 3
40 Heart And Lung Failure - Pediatric INsulin Titration Trial Completed NCT01565941 Phase 3 Insulin;Insulin
41 Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Primary Central Nervous System (CNS) Germ Cell Tumor Completed NCT00085098 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
42 Pazopanib Versus Placebo in Patients With Soft Tissue Sarcoma Whose Disease Has Progressed During or Following Prior Therapy Completed NCT00753688 Phase 3 PAZOPANIB;Placebo
43 Effect of Vitamin K on Age-Related Bone Loss and Vascular Calcification Completed NCT00183001 Phase 3 Vitamin K
44 Renin-angiotensin-aldosterone System (RAAS), Inflammation, and Post-Operative Atrial Fibrillation (AF) Completed NCT00141778 Phase 2, Phase 3 Placebo;Ramipril;Spironolactone
45 BMS-Reyataz Study in Treatment in Naive Subjects to Compare the Efficacy and Safety Between Boosted Reyataz and Kaletra When in Combination With Fixed Dose Truvada Completed NCT00272779 Phase 3 ATV;RTV;Tenofovi-Emtricitabine (TDF/FTC) tablet;LPV
46 Safety and Quality of Life Study of Aflibercept in Patients With Metastatic Colorectal Cancer Previously Treated With an Oxaliplatin-Based Regimen Completed NCT01571284 Phase 3 AFLIBERCEPT AVE0005;FOLFIRI
47 Extension Study to VEG105192 to Assess Pazopanib in Patients With Advanced/Metastatic Renal Cell Cancer Completed NCT00387764 Phase 3 pazopanib
48 BIBW 2992 (Afatinib) vs Gemcitabine-cisplatin in 1st Line Non-small Cell Lung Cancer (NSCLC) Completed NCT01121393 Phase 3 Gemcitabine+Cisplatin;BIBW 2992
49 Axitinib (AG 013736) As Second Line Therapy For Metastatic Renal Cell Cancer Completed NCT00678392 Phase 3 Axitinib (AG-013736);Sorafenib
50 A Clinical Trial Testing The Efficacy Of Crizotinib Versus Standard Chemotherapy Pemetrexed Plus Cisplatin Or Carboplatin In Patients With ALK Positive Non Squamous Cancer Of The Lung Completed NCT01154140 Phase 3 treatment;treatment

Search NIH Clinical Center for Hypokalemia

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Genetic Tests for Hypokalemia

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Genetic tests related to Hypokalemia:

# Genetic test Affiliating Genes
1 Hypokalemia 29
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Anatomical Context for Hypokalemia

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MalaCards organs/tissues related to Hypokalemia:

41
Heart, Kidney, Liver, Lung, Bone, Brain, Myeloid
Sources

Publications for Hypokalemia

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Articles related to Hypokalemia:

(show top 50) (show all 1057)
# Title Authors Year
1
Genetic screening for Bartter syndrome and Gitelman syndrome pathogenic genes among individuals with hypertension and hypokalemia. ( 29953267 )
2018
2
Effects of antiarrhythmics and hypokalemia on the rate adaptation of cardiac repolarization. ( 29798684 )
2018
3
Potential Usefulness of Early Potassium Supplementation for Preventing Severe Hypokalemia Induced by Liposomal Amphotericin B in Hematologic Patients: A Retrospective Study. ( 29305017 )
2018
4
Hypokalemia: a clinical update. ( 29540487 )
2018
5
Nafcillin-Associated Hypokalemia. ( 29672332 )
2018
6
Regional anesthesia is safe and effective for lower limb orthopedic surgery in patient with renal tubular acidosis and hypokalemia. ( 29643635 )
2018
7
Chest pain as a manifestation of hypokalemia in a pediatric patient. ( 29126579 )
2018
8
Prognostic Impact of Mild Hypokalemia in Terms of Death and Stroke in the General Population-A Prospective Population Study. ( 29024624 )
2018
9
ECG Changes of Severe Hypokalemia. ( 29490087 )
2018
10
Refractory Hypokalemia from Syndrome of Apparent Mineralocorticoid Excess on Low-Dose Posaconazole. ( 29661880 )
2018
11
Clinical characterization and diagnosis of cystic fibrosis through exome sequencing in Chinese infants with Bartter-syndrome-like hypokalemia alkalosis. ( 29520692 )
2018
12
Hypokalemia in an end stage renal disease patient. ( 29842873 )
2018
13
Comments on the Prognostic Impact of Mild Hypokalemia. ( 29555045 )
2018
14
First-Episode Psychosis and Hypokalemia: A Case Report and Review of the Literature. ( 29944416 )
2018
15
Hypokalemia associated with pseudo-Cushing's syndrome and magnesium deficiency induced by chronic alcohol abuse. ( 29450857 )
2018
16
Itraconazole induced hypertension and hypokalemia: Mechanistic evaluation. ( 29385285 )
2018
17
A Young Patient with Leg Weakness and Hypokalemia-Case Report. ( 29514039 )
2018
18
A rare case of hypokalemia-induced rhabdomyolysis. ( 29915623 )
2018
19
Incident Hyperkalemia, Hypokalemia, and Clinical Outcomes During Spironolactone Treatment of Heart Failure With Preserved Ejection Fraction: Analysis of the TOPCAT Trial. ( 29572190 )
2018
20
Protection against severe hypokalemia but impaired cardiac repolarization after intense rowing exercise in healthy humans receiving salbutamol. ( 29745804 )
2018
21
Hypokalemia ( 29494072 )
2018
22
An initial evaluation of hypokalemia turned out distal renal tubular acidosis secondary to parathyroid adenoma. ( 30381523 )
2018
23
Severe hypokalemia with cardiac arrest as an unusual manifestation of alcoholism. ( 30357049 )
2018
24
The Case | Severe hypokalemia and metabolic acidosis. ( 29680030 )
2018
25
The Case | Severe hypokalemia complicated by a syncope. ( 29933854 )
2018
26
Prolonged attacks of weakness with hypokalemia in SCN4A-related paramyotonia congenita. ( 30028520 )
2018
27
Refractory hypokalemia while weaning off bypass. ( 30052224 )
2018
28
Ibuprofen Abuse-A Case of Rhabdomyolysis, Hypokalemia, and Hypophosphatemia With Drug-Induced Mixed Renal Tubular Acidosis. ( 30197993 )
2018
29
Posaconazole-induced hypertension and hypokalemia due to inhibition of the 11β-hydroxylase enzyme. ( 30289132 )
2018
30
Severe Hypokalemia Mimicking Brain Death. ( 30294136 )
2018
31
Serious Hypokalemia Associated with Abiraterone Acetate in Patients with Castration-Resistant Prostate Cancer. ( 30305978 )
2018
32
Prevalence and risk factors for hypokalemia in patients scheduled for laparoscopic colorectal resection and its association with post-operative recovery. ( 30340534 )
2018
33
A case of hypokalemia and proteinuria with a new mutation in the SLC12A3 Gene. ( 30340552 )
2018
34
Prognostic Utility of Hypokalemia in Cirrhotic Patients. ( 30350528 )
2018
35
Oral acyclovir induced hypokalemia and acute tubular necrosis a case report. ( 30428841 )
2018
36
Hypokalemia-Induced Arrhythmias and Heart Failure: New Insights and Implications for Therapy. ( 30464746 )
2018
37
Association between hypokalemia and small bowel capsule endoscopy completion rates in patients in South China: A prospective single-center study. ( 30479322 )
2018
38
Hypokalemia Associated With a Claudin 10 Mutation: A Case Report. ( 30482581 )
2018
39
Patients with hypokalemia develop WNK bodies in the distal convoluted tubule of the kidney. ( 30484345 )
2018
40
Primary biliary cirrhosis with refractory hypokalemia: A case report. ( 30508897 )
2018
41
Electrocardiographic manifestations in severe hypokalemia. ( 30509119 )
2018
42
A Case of Hypokalemia Possibly Induced by Nafcillin. ( 30545049 )
2018
43
Chronic hypokalemia due to gastric exclusion after bariatric surgery. ( 30553575 )
2018
44
Effects of aristolochic acid I and/or hypokalemia on tubular damage in C57BL/6 rat with aristolochic acid nephropathy. ( 28192889 )
2018
45
Hypokalemia due to excessive cola consumption. ( 28736066 )
2017
46
Hypokalemia Presenting as Acute Psychosis. ( 28782327 )
2017
47
Persistent severe hypokalemia: Gitelman syndrome and differential diagnosis. ( 29044344 )
2017
48
Incidence and determinants of hyperkalemia and hypokalemia in a large healthcare system. ( 28735756 )
2017
49
Torsade de Pointes Induced by Hypokalemia from Imipenem and Piperacillin. ( 28638664 )
2017
50
Diospyros rhodocalyx (Tako-Na), a Thai folk medicine, associated with hypokalemia and generalized muscle weakness: a case series. ( 28617146 )
2017
Sources

Variations for Hypokalemia

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ClinVar genetic disease variations for Hypokalemia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SLC12A3 NM_000339.2(SLC12A3): c.2221G> A (p.Gly741Arg) single nucleotide variant Conflicting interpretations of pathogenicity rs138977195 GRCh37 Chromosome 16, 56921879: 56921879
2 SLC12A3 NM_000339.2(SLC12A3): c.2221G> A (p.Gly741Arg) single nucleotide variant Conflicting interpretations of pathogenicity rs138977195 GRCh38 Chromosome 16, 56887967: 56887967
3 SLC12A3 NM_000339.2(SLC12A3): c.457G> A (p.Val153Met) single nucleotide variant Uncertain significance rs779074538 GRCh37 Chromosome 16, 56902236: 56902236
4 SLC12A3 NM_000339.2(SLC12A3): c.457G> A (p.Val153Met) single nucleotide variant Uncertain significance rs779074538 GRCh38 Chromosome 16, 56868324: 56868324
Sources

Expression for Hypokalemia

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Search GEO for disease gene expression data for Hypokalemia.
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Pathways for Hypokalemia

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Pathways related to Hypokalemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Peptide hormone metabolism 66
Show member pathways
 11.76 ACE POMC REN
2
Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics 61
Show member pathways
 11.34 ACE NR3C2 REN
3
Renin secretion 37
11.14 ACE CACNA1S REN
4
Aldosterone-regulated sodium reabsorption 37
10.7 HSD11B2 KCNJ1 NR3C2
5
Diuretics Pathway, Pharmacodynamics 61
10.48 BSND CLCNKB KCNJ1 SLC12A1 SLC12A3
Sources

GO Terms for Hypokalemia

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Cellular components related to Hypokalemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.85 ACE AQP2 BSND CACNA1S CLCNKB HSD11B2
2 membrane GO:0016020 9.73 ACE AQP2 BSND CACNA1S CLCNKB HSD11B2
3 plasma membrane GO:0005886 9.32 ACE AQP2 BSND CACNA1S CLCNKB KCNH2

Biological processes related to Hypokalemia according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 ion transmembrane transport GO:0034220 9.78 BSND CLCNKB KCNJ1 SLC12A1
2 ion transport GO:0006811 9.73 CACNA1S CLCNKB KCNH2 KCNJ1 SLC12A1 SLC12A3
3 potassium ion transport GO:0006813 9.71 KCNH2 KCNJ1 SLC12A1
4 regulation of ion transmembrane transport GO:0034765 9.71 CACNA1S CLCNKB KCNH2 KCNJ1
5 regulation of blood pressure GO:0008217 9.63 ACE POMC REN
6 transmembrane transport GO:0055085 9.63 AQP2 CACNA1S CLCNKB KCNH2 SLC12A1 SLC12A3
7 potassium ion import across plasma membrane GO:1990573 9.61 KCNJ1 SLC12A1 SLC12A3
8 cell volume homeostasis GO:0006884 9.55 SLC12A1 SLC12A3
9 excretion GO:0007588 9.54 AQP2 CLCNKB KCNJ1
10 amyloid-beta metabolic process GO:0050435 9.52 ACE REN
11 angiotensin maturation GO:0002003 9.51 ACE REN
12 potassium ion import GO:0010107 9.5 KCNJ1 SLC12A1 SLC12A3
13 chloride ion homeostasis GO:0055064 9.49 SLC12A1 SLC12A3
14 chloride transmembrane transport GO:1902476 9.26 BSND CLCNKB SLC12A1 SLC12A3
15 potassium ion homeostasis GO:0055075 8.8 KCNH2 SLC12A1 SLC12A3

Molecular functions related to Hypokalemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.61 CACNA1S KCNH2 KCNJ1
2 inward rectifier potassium channel activity GO:0005242 9.46 KCNH2 KCNJ1
3 voltage-gated chloride channel activity GO:0005247 9.4 BSND CLCNKB
4 potassium:chloride symporter activity GO:0015379 9.37 SLC12A1 SLC12A3
5 cation:chloride symporter activity GO:0015377 9.32 SLC12A1 SLC12A3
6 sodium ion transmembrane transporter activity GO:0015081 9.26 SLC12A1 SLC12A3
7 sodium:chloride symporter activity GO:0015378 9.16 SLC12A1 SLC12A3
8 sodium:potassium:chloride symporter activity GO:0008511 8.96 SLC12A1 SLC12A3
9 steroid binding GO:0005496 8.8 HSD11B2 NR3C1 NR3C2
Sources

Sources for Hypokalemia

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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