MCID: HYP081
MIFTS: 48

Hypolipoproteinemia

Categories: Rare diseases, Metabolic diseases

Aliases & Classifications for Hypolipoproteinemia

MalaCards integrated aliases for Hypolipoproteinemia:

Name: Hypolipoproteinemia 12 76 53 15
Lipoprotein Deficiencies 12 55
Lipoprotein Disorder 55 73
Hypolipoproteinaemia 12
Hypolipoproteinemias 44

Classifications:



External Ids:

Disease Ontology 12 DOID:1387
ICD10 33 E78.6
ICD9CM 35 272.5
MeSH 44 D007009

Summaries for Hypolipoproteinemia

NIH Rare Diseases : 53 Hypolipoproteinemia refers to unusually low levels of fats (lipids) in the blood. Low lipid levels may be caused by rare genetic conditions, or be a sign of another disorder such as overactive thyroid, anemia, undernutrition, cancer, chronic infection, or impaired absorption of foods from the digestive tract. Associated genetic disorders includes abetalipoproteinemia, familial hypobetalipoproteinemia, and chylomicron retention disease. Signs and symptoms in the the genetic or familial form of hypolipoproteinemia vary. In hypobetalipoproteinemia the low density lipoprotein (LDL) cholesterol levels are very low, yet people with this syndrome typically have no symptoms nor require treatment. Other forms result in absent or near absent LDL levels and can cause serious symptoms in infancy and early childhood. Treatment for hypoproteinemia varies depending on the underlying cause and signs and symptoms present in each individual. 

MalaCards based summary : Hypolipoproteinemia, also known as lipoprotein deficiencies, is related to hypoalphalipoproteinemia, primary and fish-eye disease. An important gene associated with Hypolipoproteinemia is ABCA1 (ATP Binding Cassette Subfamily A Member 1), and among its related pathways/superpathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). The drugs Folic Acid and Niacin have been mentioned in the context of this disorder. Affiliated tissues include liver, thyroid and endothelial, and related phenotypes are Decreased free cholesterol and Increased LDL uptake

Wikipedia : 76 Hypolipoproteinemia, hypolipidemia, or hypolipidaemia (British English) is a form of dyslipidemia that... more...

Related Diseases for Hypolipoproteinemia

Diseases related to Hypolipoproteinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 hypoalphalipoproteinemia, primary 30.9 ABCA1 APOA1 APOA2 APOB LCAT LPL
2 fish-eye disease 30.3 APOA1 APOA2 LCAT
3 tangier disease 29.9 ABCA1 APOA1 APOA2 APOB APOE LCAT
4 abetalipoproteinemia 29.6 APOA1 APOB APOE LCAT LPL MTTP
5 hypobetalipoproteinemia, familial, 1 28.7 ANGPTL3 APOA1 APOB APOE LCAT MTTP
6 lecithin:cholesterol acyltransferase deficiency 28.0 APOA1 APOA2 APOB APOE LCAT LPA
7 wolman disease with hypolipoproteinemia and acanthocytosis 12.0
8 xanthoma disseminatum 10.5 APOB APOE
9 hyperlipidemia, combined, 1 10.5 APOB LPL
10 hypercholesterolemia, autosomal dominant, type b 10.5 APOB APOE
11 hyperlipoproteinemia, type v 10.5 APOE LPL
12 sea-blue histiocyte disease 10.4 APOE LCAT
13 recurrent acute pancreatitis 10.4 APOE LPL
14 apo a-i deficiency 10.3 APOA1 LCAT
15 choreoacanthocytosis 10.2
16 homozygous familial hypercholesterolemia 10.2 APOB APOE LPL
17 defective apolipoprotein b-100 10.2 APOB APOE LCAT
18 cerebral amyloid angiopathy, cst3-related 10.2 ABCA1 APOE
19 cerebral atherosclerosis 10.2 APOA1 APOE
20 dysbaric osteonecrosis 10.1 APOA1 APOB
21 aortic atherosclerosis 10.1 ABCA1 APOE LPA
22 vitamin e, familial isolated deficiency of 10.0 ABCA1 APOA1 APOB
23 smith-lemli-opitz syndrome 10.0 ABCA1 APOE
24 hypertriglyceridemia, familial 10.0 APOA1 APOB LPL
25 hepatic lipase deficiency 10.0 APOA1 APOE LPL
26 fetal macrosomia 10.0 APOA1 APOB LCAT
27 macular degeneration, age-related, 1 10.0 ABCA1 APOB APOE
28 coronary stenosis 9.9 APOA1 APOB APOE
29 brain injury 9.9
30 hepatitis 9.9
31 traumatic brain injury 9.9
32 gallbladder disease 9.9 APOA1 APOB APOE
33 schnyder corneal dystrophy 9.8 APOA2 APOB APOE
34 amyloidosis aa 9.8 APOA1 LCAT LPA
35 cerebrovascular disease 9.8 APOA1 APOB APOE
36 hereditary amyloidosis 9.8 APOA1 APOA2
37 peripheral vascular disease 9.8 APOA1 APOB LPA
38 xanthomatosis 9.7 APOB APOE LPA LPL
39 stroke, ischemic 9.7 APOB APOE LPA
40 ischemic heart disease 9.6 APOA1 APOB APOE LPL
41 bardet-biedl syndrome 2 9.6 APOA1 LPL
42 diabetes mellitus, insulin-dependent 9.5 APOA1 APOB LPA
43 amyloidosis, familial visceral 9.5 APOA1 APOA2 LPA
44 carotid artery disease 9.4 APOA1 APOB APOE LPA
45 hypertension, essential 9.4 APOA1 APOB LPA LPL
46 arteriosclerosis 9.4 APOA1 APOB APOE LPA
47 chylomicron retention disease 9.3 APOA1 APOB MTTP SAR1B
48 familial lcat deficiency 9.3 APOA1 APOA2 APOE LCAT
49 heart disease 9.2 ABCA1 APOA1 APOB APOE LPL
50 arteries, anomalies of 9.1 ABCA1 APOA1 APOB APOE LPA

Graphical network of the top 20 diseases related to Hypolipoproteinemia:



Diseases related to Hypolipoproteinemia

Symptoms & Phenotypes for Hypolipoproteinemia

GenomeRNAi Phenotypes related to Hypolipoproteinemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.43 ABCA1 APOA1 APOB APOE LPA LPL
2 Increased LDL uptake GR00340-A-1 8.8 APOA1 APOE LPL

MGI Mouse Phenotypes related to Hypolipoproteinemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 MTTP ABCA1 APOA1 APOB APOE LCAT
2 homeostasis/metabolism MP:0005376 9.65 MTTP SAR1B ABCA1 ANGPTL3 APOA1 APOA2
3 liver/biliary system MP:0005370 9.23 MTTP ABCA1 ANGPTL3 APOA1 APOB APOE

Drugs & Therapeutics for Hypolipoproteinemia

Drugs for Hypolipoproteinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 59-30-3 6037
2
Niacin Approved, Investigational, Nutraceutical Phase 4,Not Applicable 59-67-6 938
3
Nicotinamide Approved, Investigational, Nutraceutical Phase 4,Not Applicable 98-92-0 936
4 Antimetabolites Phase 4,Phase 2,Not Applicable
5 Hypolipidemic Agents Phase 4,Phase 2,Not Applicable
6 Lipid Regulating Agents Phase 4,Phase 2,Not Applicable
7 Micronutrients Phase 4,Phase 3,Not Applicable
8 Nicotinic Acids Phase 4,Not Applicable
9 Trace Elements Phase 4,Phase 3,Not Applicable
10 Vasodilator Agents Phase 4,Not Applicable
11 Vitamin B Complex Phase 4,Not Applicable
12 Vitamins Phase 4,Phase 3,Not Applicable
13 Folate Nutraceutical Phase 4,Not Applicable
14 Vitamin B3 Nutraceutical Phase 4,Not Applicable
15 Vitamin B9 Nutraceutical Phase 4,Not Applicable
16
Cosyntropin Approved Phase 3 16960-16-0 16129617
17
Epinephrine Approved, Vet_approved Phase 3 51-43-4 5816
18
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
19
Racepinephrine Approved Phase 3 329-65-7 838
20
Tocopherol Approved, Investigational, Nutraceutical Phase 3 1406-66-2 14986
21
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
22 Antioxidants Phase 3
23 Protective Agents Phase 3
24 Tocopherols Phase 3
25 Tocotrienols Phase 3
26 Adrenergic Agents Phase 3
27 Adrenergic Agonists Phase 3
28 Adrenergic alpha-Agonists Phase 3
29 Adrenergic beta-Agonists Phase 3
30 Anti-Asthmatic Agents Phase 3
31 Autonomic Agents Phase 3
32 Bronchodilator Agents Phase 3
33 Cortisol succinate Phase 3
34 Epinephryl borate Phase 3
35 Hormone Antagonists Phase 3
36 Hormones Phase 3
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
38 Hydrocortisone 17-butyrate 21-propionate Phase 3
39 Hydrocortisone acetate Phase 3
40 Mydriatics Phase 3
41 Neurotransmitter Agents Phase 3
42 Peripheral Nervous System Agents Phase 3
43 Respiratory System Agents Phase 3
44 Vasoconstrictor Agents Phase 3
45 Tocotrienol Investigational, Nutraceutical Phase 3 6829-55-6
46
Mipomersen Approved, Investigational Phase 2 1000120-98-8
47 Anticholesteremic Agents Phase 2,Not Applicable
48 Liver Extracts Phase 2
49
Fenofibrate Approved Not Applicable 49562-28-9 3339
50
Adenosine Approved, Investigational Not Applicable 58-61-7 60961

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Exercise Versus Niacin in Patients With Coronary Artery Disease (CAD) and Low High-Density Lipoproteins (HDL) Completed NCT00298909 Phase 4 niaspan (extended-release niacin);niacin
2 Short-term Effect of Extended-release Niacin on Endothelial Function. Completed NCT01942291 Phase 4 Niacin
3 Study of the Absorption of Vitamin E Water-soluble Form (Pegylated) in the Familial Hypocholesterolemia With Chylomicron Retention Completed NCT01457690 Phase 3 Tocofersolan;tocopherol alpha;Tocofersolan and tocopherol alpha
4 Effect of High Protein Diet on Adiponectin and Inflammation Among Overweight and Obese Children Completed NCT01886495 Phase 3
5 Effect of High Protein Diet on Cardiovascular Diseases Risk Factors Among Overweight and Obese Children Completed NCT01886482 Phase 3
6 High Protein Weight Loss Diet, High Sensitivity C-Reactive Protein and Cardiovascular Risks Among Obese Women Completed NCT01763528 Phase 3
7 CER-001 Therapy as a Novel Approach to Treat Genetic Orphan Diseases Recruiting NCT02697136 Phase 3 CER-001;Placebo
8 Is Adrenal Insufficiency Under-diagnosed in Hospitalized Cirrhosis Patients? Recruiting NCT03368066 Phase 3 Cosyntropin
9 Measure Liver Fat Content After ISIS 301012 (Mipomersen) Administration Completed NCT00362180 Phase 2 mipomersen;Placebo
10 High-Density Lipoprotein (HDL) Treatment Study Completed NCT00458055 Not Applicable Atorvastatin; Fenofibrate; Niacin
11 Prevalence Assessment and Characterization of Psychological Disorders Associated With Hypobetalipoproteinemia Completed NCT02889614
12 Tomato Consumption and High Density Lipoprotein-cholesterol Completed NCT01342666 Not Applicable
13 Mechanisms of Low Levels of Apolipoprotein B Completed NCT00005565
14 Vitamin Replacement in Abetalipoproteinemia Completed NCT00004574
15 Quantitative Genetic Analysis of Lipid Research Clinic Family Data Completed NCT00005188
16 Evaluation of Lipoproteins Recruiting NCT00001168
17 HYPOCHOL : A Genetically-based Strategy to Identify New Targets in Cholesterol Metabolism Recruiting NCT02354079 Not Applicable
18 Inherited Retinal Degenerative Disease Registry Recruiting NCT02435940
19 Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins Recruiting NCT00001154
20 Habitual Diet and Avocado Trial Not yet recruiting NCT03528031 Not Applicable
21 Prevalence of fAmilial hypobetalipopRoTeinemIa in psychiaTrIc pOpulatioN (PARTITION) Not yet recruiting NCT03549637 Not Applicable
22 Mendelian Reverse Cholesterol Transport Study Suspended NCT01782027 Not Applicable 3H-cholesterol bound to albumin

Search NIH Clinical Center for Hypolipoproteinemia

Cochrane evidence based reviews: hypolipoproteinemias

Genetic Tests for Hypolipoproteinemia

Anatomical Context for Hypolipoproteinemia

MalaCards organs/tissues related to Hypolipoproteinemia:

41
Liver, Thyroid, Endothelial, Heart, Eye, Brain

Publications for Hypolipoproteinemia

Articles related to Hypolipoproteinemia:

(show all 47)
# Title Authors Year
1
Significant association between hypolipoproteinemia(a) and lifetime risk of cancer: an autopsy study from a community-based Geriatric Hospital. ( 25164551 )
2014
2
A kindred with fish eye disease, corneal opacities, marked high-density lipoprotein deficiency, and statin therapy. ( 24636183 )
2014
3
Severe high-density lipoprotein deficiency associated with autoantibodies against lecithin:cholesterol acyltransferase in non-Hodgkin lymphoma. ( 22271127 )
2012
4
Marked high density lipoprotein deficiency due to apolipoprotein A-I Tomioka (codon 138 deletion). ( 19473658 )
2009
5
Hypolipoproteinemia and hyperinflammatory cytokines in serum of severe and moderate traumatic brain injury (TBI) patients. ( 17993453 )
2007
6
Differential diagnosis of familial high density lipoprotein deficiency syndromes. ( 16343506 )
2006
7
Paraoxonase 1 (PON1) is a more potent antioxidant and stimulant of macrophage cholesterol efflux, when present in HDL than in lipoprotein-deficient serum: relevance to diabetes. ( 16229851 )
2006
8
High-density lipoprotein deficiency and dyslipoproteinemia associated with venous thrombosis in men. ( 16087810 )
2005
9
Impaired platelet activation in familial high density lipoprotein deficiency (Tangier disease). ( 15163665 )
2004
10
A novel two nucleotide deletion in the apolipoprotein A-I gene, apoA-I Shinbashi, associated with high density lipoprotein deficiency, corneal opacities, planar xanthomas, and premature coronary artery disease. ( 14709355 )
2004
11
Expression and functional analyses of novel mutations of ATP-binding cassette transporter-1 in Japanese patients with high-density lipoprotein deficiency. ( 11785958 )
2002
12
Homogeneous assay based on 52 primer sets to scan for mutations of the ABCA1 gene and its application in genetic analysis of a new patient with familial high-density lipoprotein deficiency syndrome. ( 11476961 )
2001
13
Novel mutations in ABCA1 gene in Japanese patients with Tangier disease and familial high density lipoprotein deficiency with coronary heart disease. ( 11476965 )
2001
14
High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1. ( 10760292 )
2000
15
Cholesterol efflux regulatory protein, Tangier disease and familial high-density lipoprotein deficiency. ( 10787172 )
2000
16
Cholesterol efflux from normal and Tangier disease fibroblasts into normal, high-density lipoprotein-deficient, and apolipoprotein E-deficient plasmas. ( 10877205 )
2000
17
Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. ( 10431236 )
1999
18
Functional lecithin:cholesterol acyltransferase deficiency and high density lipoprotein deficiency in transgenic mice overexpressing human apolipoprotein A-II. ( 8636092 )
1996
19
Remodeling of HDL containing apoA-I but not apoA-II (LpA-I) by lipoprotein-deficient plasma and hepatic lipase: its effect on the structure and cellular cholesterol-reducing capacity of LpA-I. ( 8856043 )
1996
20
The pathology of cornea in Tangier disease (familial high density lipoprotein deficiency). ( 8707957 )
1996
21
The heparin-bound fraction of human lipoprotein-deficient serum inhibits endocytic uptake of oxidized low density lipoprotein by macrophages. ( 8645358 )
1996
22
A nonsense mutation in the apolipoprotein A-I gene is associated with high-density lipoprotein deficiency and periorbital xanthelasmas. ( 7981179 )
1994
23
Characterization of apolipoprotein A-I- and A-II-containing lipoproteins in a new case of high density lipoprotein deficiency resembling Tangier disease and their effects on intracellular cholesterol efflux. ( 8432861 )
1993
24
High density lipoprotein deficiency with xanthomas. A defect in reverse cholesterol transport caused by a point mutation in the apolipoprotein A-I gene. ( 7693760 )
1993
25
Elevated complement activities of sera from patients with high density lipoprotein deficiency (Tangier disease): the presence of normal level of clusterin and the possible implication in the atherosclerosis. ( 8348751 )
1993
26
Determination of lipid transfer inhibitor protein activity in human lipoprotein-deficient plasma. ( 8241106 )
1993
27
Familial high-density-lipoprotein deficiency causing corneal opacities (fish eye disease) in a family of Dutch descent. ( 1588268 )
1992
28
Acquired hypolipoproteinemia. ( 1582035 )
1992
29
A frameshift mutation in the human apolipoprotein A-I gene causes high density lipoprotein deficiency, partial lecithin: cholesterol-acyltransferase deficiency, and corneal opacities. ( 1898657 )
1991
30
Familial high-density lipoprotein deficiency (Tangier disease): the third Italian case. ( 3141697 )
1988
31
The degradation of platelet-activating factor in the plasma of a patient with familial high density lipoprotein deficiency (Tangier disease). ( 4063532 )
1985
32
Apolipoprotein AI and AII metabolism in patients with primary high-density lipoprotein deficiency associated with familial hypertriglyceridemia. ( 3927110 )
1985
33
Bile lipid composition and haemostatic variables in a case of high density lipoprotein deficiency (Tangier disease). ( 6421598 )
1984
34
[Genetic hypolipoproteinemias]. ( 6320428 )
1983
35
Tangier disease. High density lipoprotein deficiency due to defective metabolism of an abnormal apolipoprotein A-i (ApoA-ITangier). ( 7130397 )
1982
36
Coronary heart disease prevalence and other clinical features in familial high-density lipoprotein deficiency (Tangier disease). ( 7406376 )
1980
37
Ocular manifestations of familial high-density lipoprotein deficiency (Tangier disease). ( 226043 )
1979
38
Tangier disease (alpha-lipoprotein deficiency). ( 195100 )
1977
39
Autoantibodies with antilipoprotein specificity and hypolipoproteinemia in patients with cancer. ( 163682 )
1975
40
Acrodermatitis enteropathica associated with low density lipoproteins deficiency. ( 4369743 )
1974
41
Wolman's disease with hypolipoproteinemia and acanthocytosis: clinical and biochemical observations. ( 5504079 )
1970
42
Hepatitis secondary to pyrazinamide toxicity: accompaniments of transient hypolipoproteinemia, acanthocytosis, and changes in stomach and small bowel. ( 5411920 )
1970
43
Acanthocytosis with beta-lipoprotein deficiency in an Indian girl. ( 5491083 )
1970
44
Neuropathy in Tangier disease. Alpha-Lipoprotein deficiency manifesting as familial recurrent neuropathy and intestinal lipid storage. ( 4165386 )
1967
45
Familial alpha-lipoprotein deficiency (Tangier disease) with neurological abnormalities. ( 4165172 )
1967
46
Tangier disease (familial high density lipoprotein deficiency). Clinical and genetic features in two adults. ( 5831900 )
1965
47
THE INHERITANCE OF HIGH DENSITY LIPOPROTEIN DEFICIENCY (TANGIER DISEASE). ( 14162531 )
1964

Variations for Hypolipoproteinemia

Expression for Hypolipoproteinemia

Search GEO for disease gene expression data for Hypolipoproteinemia.

Pathways for Hypolipoproteinemia

Pathways related to Hypolipoproteinemia according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.63 ABCA1 ANGPTL3 APOA1 APOA2 APOB APOE
2
Show member pathways
12.6 ABCA1 APOA1 APOA2 LPL
3
Show member pathways
12.41 APOA1 APOA2 APOB APOE LPL
4
Show member pathways
12.23 ABCA1 ANGPTL3 APOA1 APOA2 APOB APOE
5
Show member pathways
12.07 ABCA1 APOA1 APOB APOE
6
Show member pathways
12.05 APOA1 APOA2 APOB APOE LPL
7
Show member pathways
11.67 APOA1 APOB APOE
8 11.49 APOA1 APOA2 LPL
9
Show member pathways
11.39 ABCA1 ANGPTL3 APOA1 APOA2 APOB APOE
10
Show member pathways
11.1 ABCA1 APOA1 APOB MTTP
11 10.93 APOA1 APOA2
12 10.87 APOA1 APOB
13 10.82 ABCA1 APOA1 APOA2

GO Terms for Hypolipoproteinemia

Cellular components related to Hypolipoproteinemia according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 Golgi apparatus GO:0005794 9.96 ABCA1 ANGPTL3 APOE MTTP SAR1B
2 cell surface GO:0009986 9.85 ABCA1 ANGPTL3 APOA1 LPL
3 endoplasmic reticulum lumen GO:0005788 9.83 APOA1 APOA2 APOB APOE MTTP
4 early endosome GO:0005769 9.8 ANGPTL3 APOA1 APOA2 APOB APOE
5 extracellular matrix GO:0031012 9.74 APOA1 APOE LPL
6 blood microparticle GO:0072562 9.7 APOA1 APOA2 APOE
7 high-density lipoprotein particle GO:0034364 9.55 ABCA1 APOA1 APOA2 APOE LCAT
8 clathrin-coated endocytic vesicle membrane GO:0030669 9.54 APOB APOE
9 endocytic vesicle lumen GO:0071682 9.54 APOA1 APOB APOE
10 spherical high-density lipoprotein particle GO:0034366 9.51 APOA1 APOA2
11 low-density lipoprotein particle GO:0034362 9.5 APOA1 APOB APOE
12 discoidal high-density lipoprotein particle GO:0034365 9.46 APOA1 APOE
13 intermediate-density lipoprotein particle GO:0034363 9.43 APOA1 APOB APOE
14 very-low-density lipoprotein particle GO:0034361 9.35 APOA1 APOA2 APOB APOE LPL
15 chylomicron GO:0042627 9.02 APOA1 APOA2 APOB APOE LPL
16 extracellular region GO:0005576 10.08 ANGPTL3 APOA1 APOA2 APOB APOE LCAT
17 extracellular space GO:0005615 10.04 ANGPTL3 APOA1 APOA2 APOB APOE LCAT

Biological processes related to Hypolipoproteinemia according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Name GO ID Score Top Affiliating Genes
1 steroid metabolic process GO:0008202 9.99 ABCA1 APOA1 APOB APOE LCAT
2 lipid transport GO:0006869 9.98 ABCA1 APOA1 APOA2 APOB APOE LPA
3 cellular protein metabolic process GO:0044267 9.97 APOA1 APOA2 APOB APOE
4 retinoid metabolic process GO:0001523 9.96 APOA1 APOA2 APOB APOE LPL
5 phospholipid metabolic process GO:0006644 9.93 ANGPTL3 APOA1 LCAT LPL
6 receptor-mediated endocytosis GO:0006898 9.9 APOA1 APOB APOE
7 triglyceride metabolic process GO:0006641 9.9 APOA2 APOE LPL MTTP
8 cholesterol transport GO:0030301 9.89 ABCA1 APOA1 APOA2 APOB LCAT
9 regulation of lipid metabolic process GO:0019216 9.88 ABCA1 APOA1 APOA2
10 triglyceride homeostasis GO:0070328 9.88 ANGPTL3 APOA1 APOE LPL
11 triglyceride catabolic process GO:0019433 9.88 APOA1 APOB APOE LPL
12 cholesterol efflux GO:0033344 9.88 ABCA1 APOA1 APOA2 APOB APOE
13 high-density lipoprotein particle remodeling GO:0034375 9.87 APOA1 APOA2 APOE LCAT
14 high-density lipoprotein particle assembly GO:0034380 9.85 ABCA1 APOA1 APOA2 APOE
15 reverse cholesterol transport GO:0043691 9.85 ABCA1 APOA1 APOA2 APOE LCAT
16 low-density lipoprotein particle remodeling GO:0034374 9.84 APOA2 APOB APOE LPA
17 phospholipid transport GO:0015914 9.83 ABCA1 APOA1 MTTP
18 phospholipid efflux GO:0033700 9.83 ABCA1 APOA1 APOA2 APOE
19 phosphatidylcholine biosynthetic process GO:0006656 9.82 APOA1 APOA2 LCAT
20 artery morphogenesis GO:0048844 9.81 ANGPTL3 APOB APOE
21 very-low-density lipoprotein particle remodeling GO:0034372 9.81 APOA1 APOE LCAT LPL
22 positive regulation of cholesterol esterification GO:0010873 9.8 APOA1 APOA2 APOE
23 cholesterol metabolic process GO:0008203 9.8 ABCA1 ANGPTL3 APOA1 APOA2 APOB APOE
24 high-density lipoprotein particle clearance GO:0034384 9.79 APOA1 APOA2 APOE
25 phospholipid homeostasis GO:0055091 9.79 ABCA1 ANGPTL3 APOA1
26 regulation of Cdc42 protein signal transduction GO:0032489 9.78 ABCA1 APOA1 APOE
27 chylomicron assembly GO:0034378 9.77 APOA1 APOA2 APOB APOE MTTP
28 animal organ regeneration GO:0031100 9.73 APOA1 APOA2
29 cholesterol biosynthetic process GO:0006695 9.73 APOA1 APOE
30 lipid homeostasis GO:0055088 9.73 ANGPTL3 APOE
31 lipid storage GO:0019915 9.72 ANGPTL3 APOA1
32 lipoprotein transport GO:0042953 9.72 APOB MTTP
33 phospholipid catabolic process GO:0009395 9.72 ANGPTL3 APOA2
34 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.72 APOB LPL
35 chylomicron remodeling GO:0034371 9.72 APOA1 APOA2 APOB APOE LPL
36 positive regulation of lipid biosynthetic process GO:0046889 9.71 APOA1 APOE
37 positive regulation of cholesterol efflux GO:0010875 9.71 ABCA1 APOE
38 phosphatidylcholine metabolic process GO:0046470 9.71 APOA1 LCAT
39 protein lipidation GO:0006497 9.71 ABCA1 MTTP
40 very-low-density lipoprotein particle assembly GO:0034379 9.7 APOB MTTP
41 regulation of lipoprotein lipase activity GO:0051004 9.7 ANGPTL3 LPL
42 neuron projection regeneration GO:0031102 9.69 APOA1 APOE
43 chylomicron remnant clearance GO:0034382 9.69 APOB APOE
44 regulation of cholesterol transport GO:0032374 9.69 APOA1 APOE
45 positive regulation of cholesterol storage GO:0010886 9.68 APOB LPL
46 peptidyl-methionine modification GO:0018206 9.68 APOA1 APOA2
47 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 APOA1 APOA2
48 positive regulation of lipid catabolic process GO:0050996 9.68 ANGPTL3 APOA2
49 very-low-density lipoprotein particle clearance GO:0034447 9.67 APOB APOE
50 regulation of intestinal cholesterol absorption GO:0030300 9.67 APOA1 APOA2

Molecular functions related to Hypolipoproteinemia according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 lipid binding GO:0008289 9.85 APOA1 APOA2 APOB APOE MTTP
2 heparin binding GO:0008201 9.8 ANGPTL3 APOB APOE LPA LPL
3 cholesterol binding GO:0015485 9.67 ABCA1 APOA1 APOA2 APOE
4 phospholipid binding GO:0005543 9.65 ABCA1 APOA1 APOA2 APOB APOE
5 phospholipid transporter activity GO:0005548 9.61 ABCA1 APOA1 MTTP
6 phosphatidylcholine binding GO:0031210 9.57 APOA1 APOA2
7 low-density lipoprotein particle receptor binding GO:0050750 9.56 APOB APOE
8 high-density lipoprotein particle binding GO:0008035 9.55 APOA1 APOA2
9 lipoprotein particle binding GO:0071813 9.54 APOA1 APOE
10 lipase inhibitor activity GO:0055102 9.52 APOA1 APOA2
11 apolipoprotein A-I binding GO:0034186 9.51 ABCA1 LCAT
12 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.5 APOA1 APOA2 APOE
13 high-density lipoprotein particle receptor binding GO:0070653 9.49 APOA1 APOA2
14 apolipoprotein receptor binding GO:0034190 9.48 APOA1 APOA2
15 apolipoprotein binding GO:0034185 9.46 ABCA1 LPA LPL MTTP
16 lipid transporter activity GO:0005319 9.35 APOA1 APOA2 APOB APOE MTTP
17 cholesterol transporter activity GO:0017127 9.02 ABCA1 APOA1 APOA2 APOB APOE

Sources for Hypolipoproteinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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