Hypolipoproteinemia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HYP081 MIFTS: 43	Hypolipoproteinemia Categories: Blood diseases, Cancer diseases, Genetic diseases, Metabolic diseases, Rare diseases
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Aliases & Classifications for Hypolipoproteinemia

MalaCards integrated aliases for Hypolipoproteinemia:

Name: Hypolipoproteinemia ¹² ⁷⁶ ⁵³ ¹⁵

Lipoprotein Deficiencies ¹² ⁵⁵

Lipoprotein Disorder ⁵⁵ ⁷³

Hypolipoproteinaemia ¹²

Hypolipoproteinemias ⁴⁴

Classifications:

MalaCards categories:
Global: Rare diseases Metabolic diseases Cancer diseases Genetic diseases
Anatomical: Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Endocrine, nutritional and metabolic diseases

Metabolic disorders

Disorders of lipoprotein metabolism and other lipidaemias

Lipoprotein deficiency

External Ids:

Disease Ontology ¹² DOID:1387

ICD10 ³³ E78.6

ICD9CM ³⁵ 272.5

MeSH ⁴⁴ D007009

UMLS ⁷³ C0020623 C0596848

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Summaries for Hypolipoproteinemia

NIH Rare Diseases : ⁵³ Hypolipoproteinemia refers to unusually low levels of fats (lipids) in the blood. Low lipid levels may be caused by rare genetic conditions, or be a sign of another disorder such as overactive thyroid, anemia, undernutrition, cancer, chronic infection, or impaired absorption of foods from the digestive tract. Associated genetic disorders includes abetalipoproteinemia, familial hypobetalipoproteinemia, and chylomicron retention disease. Signs and symptoms in the the genetic or familial form of hypolipoproteinemia vary. In hypobetalipoproteinemia the low density lipoprotein (LDL) cholesterol levels are very low, yet people with this syndrome typically have no symptoms nor require treatment. Other forms result in absent or near absent LDL levels and can cause serious symptoms in infancy and early childhood. Treatment for hypoproteinemia varies depending on the underlying cause and signs and symptoms present in each individual.

MalaCards based summary : Hypolipoproteinemia, also known as lipoprotein deficiencies, is related to hypoalphalipoproteinemia, primary and tangier disease. An important gene associated with Hypolipoproteinemia is ABCA1 (ATP Binding Cassette Subfamily A Member 1), and among its related pathways/superpathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). The drugs Nicotinamide and Niacin have been mentioned in the context of this disorder. Affiliated tissues include liver, thyroid and brain, and related phenotypes are Decreased free cholesterol and Increased LDL uptake

Wikipedia : ⁷⁶ Hypolipoproteinemia, hypolipidemia, or hypolipidaemia (British English) is a form of dyslipidemia that... more...

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Related Diseases for Hypolipoproteinemia

Diseases related to Hypolipoproteinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)

#	Related Disease	Score	Top Affiliating Genes
1	hypoalphalipoproteinemia, primary	32.5	ABCA1 APOA1 APOA2 APOB LCAT LPL
2	tangier disease	32.5	ABCA1 APOA1 APOA2 APOB APOE LCAT
3	fish-eye disease	30.8	APOA1 APOA2 LCAT
4	abetalipoproteinemia	30.8	APOA1 APOB APOE LCAT LPL MTTP
5	lecithin:cholesterol acyltransferase deficiency	30.2	APOA1 APOA2 APOB APOE LCAT LPA
6	chylomicron retention disease	30.0	APOA1 APOB MTTP SAR1B
7	heart disease	29.4	ABCA1 APOA1 APOB APOE LPL
8	coronary artery anomaly	29.3	APOA1 APOB LPA LPL
9	arteries, anomalies of	29.1	ABCA1 APOA1 APOB APOE LPA
10	myocardial infarction	28.7	ABCA1 APOA1 APOA2 APOB APOE LPA
11	coronary heart disease 1	28.6	ABCA1 APOA1 APOA2 APOB APOE LCAT
12	wolman disease with hypolipoproteinemia and acanthocytosis	12.1
13	choreoacanthocytosis	10.2
14	hyperlipidemia, combined, 1	10.2	APOB LPL
15	xanthoma disseminatum	10.1	APOB APOE
16	hypercholesterolemia, autosomal dominant, type b	10.1	APOB APOE
17	recurrent acute pancreatitis	10.1	APOE LPL
18	apo a-i deficiency	10.1	APOA1 LCAT
19	brain injury	10.1
20	hepatitis	10.1
21	traumatic brain injury	10.1
22	defective apolipoprotein b-100	10.1	APOB APOE LCAT
23	cerebral atherosclerosis	10.1	APOA1 APOE
24	dysbaric osteonecrosis	10.1	APOA1 APOB
25	smith-lemli-opitz syndrome	10.0	ABCA1 APOE
26	sea-blue histiocyte disease	10.0	APOB APOE LCAT
27	pellagra	10.0	LPA MTTP
28	homozygous familial hypercholesterolemia	10.0	APOB APOE MTTP
29	aortic atherosclerosis	10.0	ABCA1 APOE LPA
30	huntington disease-like 1	10.0	APOB APOE LPA
31	vitamin e, familial isolated deficiency of	10.0	ABCA1 APOA1 APOB
32	hepatic lipase deficiency	10.0	APOA1 APOE LPL
33	macular degeneration, age-related, 1	10.0	ABCA1 APOB APOE
34	fetal macrosomia	10.0	APOA1 APOB LCAT
35	hyperlipoproteinemia, type iv	10.0	APOA2 APOB LPL
36	coronary stenosis	10.0	APOA1 APOB APOE
37	gallbladder disease	10.0	APOA1 APOB APOE
38	bardet-biedl syndrome 2	9.9	APOA1 LPL
39	hereditary amyloidosis	9.9	APOA1 APOA2
40	schnyder corneal dystrophy	9.9	APOA2 APOB APOE
41	amyloidosis aa	9.9	APOA1 LCAT LPA
42	cerebrovascular disease	9.9	APOA1 APOB APOE
43	peripheral vascular disease	9.9	APOA1 APOB LPA
44	xanthomatosis	9.9	APOB APOE LPA LPL
45	sitosterolemia	9.9	APOB MTTP
46	stroke, ischemic	9.9	APOB APOE LPA
47	hyperlipoproteinemia, type v	9.9	APOA1 APOB APOE LPL
48	ischemic heart disease	9.9	APOA1 APOB APOE LPL
49	hypertriglyceridemia, familial	9.9	APOA1 APOB APOE LPL
50	diabetes mellitus	9.9	APOA1 APOB LPA LPL

Graphical network of the top 20 diseases related to Hypolipoproteinemia:

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Symptoms & Phenotypes for Hypolipoproteinemia

GenomeRNAi Phenotypes related to Hypolipoproteinemia according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased free cholesterol	GR00340-A-2	9.43	ABCA1 APOA1 APOB APOE LPA LPL
2	Increased LDL uptake	GR00340-A-1	8.8	APOA1 APOE LPL

MGI Mouse Phenotypes related to Hypolipoproteinemia:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.7	ABCA1 APOA1 APOB APOE LCAT LPL
2	homeostasis/metabolism	MP:0005376	9.65	ABCA1 ANGPTL3 APOA1 APOA2 APOB APOE
3	liver/biliary system	MP:0005370	9.23	ABCA1 ANGPTL3 APOA1 APOB APOE LCAT

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Drugs & Therapeutics for Hypolipoproteinemia

Drugs for Hypolipoproteinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Nicotinamide

Approved, Investigational

Phase 4,Not Applicable

98-92-0

936

Niacin

Approved, Investigational, Nutraceutical

Phase 4,Not Applicable

59-67-6

938

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 4,Not Applicable

59-30-3

6037

Micronutrients

Phase 4,Phase 3,Not Applicable

Vasodilator Agents

Phase 4,Not Applicable

Hypolipidemic Agents

Phase 4,Phase 2,Not Applicable

Vitamin B9

Phase 4,Not Applicable

Nicotinic Acids

Phase 4,Not Applicable

Vitamins

Phase 4,Phase 3,Not Applicable

Trace Elements

Phase 4,Phase 3,Not Applicable

Antimetabolites

Phase 4,Phase 2,Not Applicable

Vitamin B3

Phase 4,Not Applicable

Folate

Phase 4,Not Applicable

Lipid Regulating Agents

Phase 4,Phase 2,Not Applicable

Vitamin B Complex

Phase 4,Not Applicable

Tocopherol

Approved, Investigational

Phase 3

1406-66-2

14986

Hydrocortisone acetate

Approved, Vet_approved

Phase 3

50-03-3

Epinephrine

Approved, Vet_approved

Phase 3

51-43-4

5816

Cosyntropin

Approved

Phase 3

16960-16-0

16129617

Racepinephrine

Approved

Phase 3

329-65-7

838

Hydrocortisone

Approved, Vet_approved

Phase 3

50-23-7

5754

Tacrolimus

Approved, Investigational

Phase 3

104987-11-3

445643 439492

Vitamin E

Approved, Nutraceutical, Vet_approved

Phase 3

59-02-9

14985

Tocotrienol

Investigational

Phase 3

6829-55-6

Antioxidants

Phase 3

Tocotrienols

Phase 3

Tocopherols

Phase 3

Protective Agents

Phase 3

Hydrocortisone 17-butyrate 21-propionate

Phase 3

Anti-Asthmatic Agents

Phase 3

Mydriatics

Phase 3

Adrenergic beta-Agonists

Phase 3

Adrenergic Agonists

Phase 3

Epinephryl borate

Phase 3

Neurotransmitter Agents

Phase 3

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 3

Respiratory System Agents

Phase 3

Adrenergic alpha-Agonists

Phase 3

Hormones

Phase 3

Peripheral Nervous System Agents

Phase 3

Hormone Antagonists

Phase 3

Autonomic Agents

Phase 3

Bronchodilator Agents

Phase 3

Adrenergic Agents

Phase 3

Sympathomimetics

Phase 3

Cortisol succinate

Phase 3

Vasoconstrictor Agents

Phase 3

Calcineurin Inhibitors

Phase 3

Immunosuppressive Agents

Phase 3

Immunologic Factors

Phase 3

Interventional clinical trials:

(show all 24)

#	Name	Status	NCT ID	Phase	Drugs
1	Exercise Versus Niacin in Patients With Coronary Artery Disease (CAD) and Low High-Density Lipoproteins (HDL)	Completed	NCT00298909	Phase 4	niaspan (extended-release niacin);niacin
2	Short-term Effect of Extended-release Niacin on Endothelial Function.	Completed	NCT01942291	Phase 4	Niacin
3	Study of the Absorption of Vitamin E Water-soluble Form (Pegylated) in the Familial Hypocholesterolemia With Chylomicron Retention	Completed	NCT01457690	Phase 3	Tocofersolan;tocopherol alpha;Tocofersolan and tocopherol alpha
4	Effect of High Protein Diet on Adiponectin and Inflammation Among Overweight and Obese Children	Completed	NCT01886495	Phase 3
5	Effect of High Protein Diet on Cardiovascular Diseases Risk Factors Among Overweight and Obese Children	Completed	NCT01886482	Phase 3
6	High Protein Weight Loss Diet, High Sensitivity C-Reactive Protein and Cardiovascular Risks Among Obese Women	Completed	NCT01763528	Phase 3
7	CER-001 Therapy as a Novel Approach to Treat Genetic Orphan Diseases	Recruiting	NCT02697136	Phase 3	CER-001;Placebo
8	Is Adrenal Insufficiency Under-diagnosed in Hospitalized Cirrhosis Patients?	Recruiting	NCT03368066	Phase 3	Cosyntropin
9	Slow and Low Start of a Tacrolimus Once Daily Immunosuppressive Regimen	Active, not recruiting	NCT03672110	Phase 3	Advagraf
10	Measure Liver Fat Content After ISIS 301012 (Mipomersen) Administration	Completed	NCT00362180	Phase 2	mipomersen;Placebo
11	High-Density Lipoprotein (HDL) Treatment Study	Completed	NCT00458055	Not Applicable	Atorvastatin; Fenofibrate; Niacin
12	Prevalence Assessment and Characterization of Psychological Disorders Associated With Hypobetalipoproteinemia	Completed	NCT02889614
13	Tomato Consumption and High Density Lipoprotein-cholesterol	Completed	NCT01342666	Not Applicable
14	Mechanisms of Low Levels of Apolipoprotein B	Completed	NCT00005565
15	Vitamin Replacement in Abetalipoproteinemia	Completed	NCT00004574
16	Quantitative Genetic Analysis of Lipid Research Clinic Family Data	Completed	NCT00005188
17	Evaluation of Lipoproteins	Recruiting	NCT00001168
18	Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins	Recruiting	NCT00001154
19	Habitual Diet and Avocado Trial	Recruiting	NCT03528031	Not Applicable
20	Prevalence of fAmilial hypobetalipopRoTeinemIa in psychiaTrIc pOpulatioN (PARTITION)	Recruiting	NCT03549637	Not Applicable
21	HYPOCHOL : A Genetically-based Strategy to Identify New Targets in Cholesterol Metabolism	Recruiting	NCT02354079	Not Applicable
22	Inherited Retinal Degenerative Disease Registry	Recruiting	NCT02435940
23	Intermittent Fasting in Dyslipidemia	Not yet recruiting	NCT03805776	Not Applicable
24	Mendelian Reverse Cholesterol Transport Study	Suspended	NCT01782027	Not Applicable	3H-cholesterol bound to albumin

Search NIH Clinical Center for Hypolipoproteinemia

Cochrane evidence based reviews: hypolipoproteinemias

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Genetic Tests for Hypolipoproteinemia

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Anatomical Context for Hypolipoproteinemia

MalaCards organs/tissues related to Hypolipoproteinemia:

⁴¹

Liver, Thyroid, Brain, Kidney, Heart, Eye

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Publications for Hypolipoproteinemia

Articles related to Hypolipoproteinemia:

#	Title	Authors	Year
1	Significant association between hypolipoproteinemia(a) and lifetime risk of cancer: an autopsy study from a community-based Geriatric Hospital. ( 25164551 )	Mieno M.N....Matsushita S.	2014
2	Hypolipoproteinemia and hyperinflammatory cytokines in serum of severe and moderate traumatic brain injury (TBI) patients. ( 17993453 )		2007
3	Hypolipidaemia is not always indicating liver dysfunction. A review of primary and secondary high density lipoprotein and low density lipoprotein deficiencies. ( 17213785 )	Andrikoula M...Avades T	2006
4	Acquired hypolipoproteinemia. ( 1582035 )	De Buyzere M...Rosseneu M	1992
5	Autoantibodies with antilipoprotein specificity and hypolipoproteinemia in patients with cancer. ( 163682 )		1975
6	Wolman's disease with hypolipoproteinemia and acanthocytosis: clinical and biochemical observations. ( 5504079 )	Eto Y....Kitagawa T.	1970
7	Hepatitis secondary to pyrazinamide toxicity: accompaniments of transient hypolipoproteinemia, acanthocytosis, and changes in stomach and small bowel. ( 5411920 )	Simpson A.J....O'Brien T.F.	1970

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Genes for Hypolipoproteinemia

Genes related to Hypolipoproteinemia (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	ABCA1	ATP Binding Cassette Subfamily A Member 1	Protein Coding	43.88	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	16702784 15019541 11785958 (more) 11476961 12706378 15177564 11558901 15209530
2	LPL	Lipoprotein Lipase	Protein Coding	30.42	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	9401010 15719845 1417963 (more) 9185775 11122693
3	APOB	Apolipoprotein B	Protein Coding	27.5	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	12545078 11861429
4	LCAT	Lecithin-Cholesterol Acyltransferase	Protein Coding	26.7	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	11122693
5	APOE	Apolipoprotein E	Protein Coding	23.7	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	12535745 1619388
6	MTTP	Microsomal Triglyceride Transfer Protein	Protein Coding	18.35	DISEASES inferred ¹⁵
7	LPA	Lipoprotein(A)	Protein Coding	18.19	DISEASES inferred ¹⁵
8	APOA1	Apolipoprotein A1	Protein Coding	17.86	DISEASES inferred ¹⁵
9	APOA2	Apolipoprotein A2	Protein Coding	17.42	DISEASES inferred ¹⁵
10	ANGPTL3	Angiopoietin Like 3	Protein Coding	17.42	DISEASES inferred ¹⁵
11	SAR1B	Secretion Associated Ras Related GTPase 1B	Protein Coding	16.84	DISEASES inferred ¹⁵

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Variations for Hypolipoproteinemia

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Expression for Hypolipoproteinemia

Search GEO for disease gene expression data for Hypolipoproteinemia.

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Pathways for Hypolipoproteinemia

Pathways related to Hypolipoproteinemia according to GeneCards Suite gene sharing:

(show all 14)

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism ⁶⁶ Show member pathways Metabolic pathways ³⁷ Metabolism of lipids and lipoproteins ⁶⁶	13.53	ABCA1 ANGPTL3 APOA1 APOA2 APOB APOE
2	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) ⁶⁶ Show member pathways Fatty acid, triacylglycerol, and ketone body metabolism ⁶⁶ PPARA activates gene expression ⁶⁶ Transcriptional regulation of white adipocyte differentiation ⁶⁶	12.6	ABCA1 APOA1 APOA2 LPL
3	Metabolism of water-soluble vitamins and cofactors ⁶⁶ Show member pathways [2Fe-2S] iron-sulfur cluster biosynthesis ¹ Biotin transport and metabolism ⁶⁶ biotin-carboxyl carrier protein assembly ¹ coenzyme A biosynthesis ¹ Coenzyme A biosynthesis ⁶⁶ flavin biosynthesis ¹ folate polyglutamylation ¹ glycine/serine biosynthesis ¹ Metabolism of folate and pterines ⁶⁶ Metabolism of vitamins and cofactors ⁶⁶ molybdenum cofactor biosynthesis ¹ Molybdenum cofactor biosynthesis ⁶⁶ thiamin salvage III ¹ thio-molybdenum cofactor biosynthesis ¹ Vitamin B1 (thiamin) metabolism ⁶⁶ Vitamin B2 (riboflavin) metabolism ⁶⁶ Vitamin B5 (pantothenate) metabolism ⁶⁶ Vitamin C (ascorbate) metabolism ⁶⁶ Vitamins B6 activation to pyridoxal phosphate ⁶⁶	12.41	APOA1 APOA2 APOB APOE LPL
4	Lipoprotein metabolism ⁶⁶ Show member pathways Chylomicron-mediated lipid transport ⁶⁶ Digestion of dietary lipid ⁶⁶ HDL-mediated lipid transport ⁶⁶ Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis ⁶⁶ LDL-mediated lipid transport ⁶⁶ Lipid digestion, mobilization, and transport ⁶⁶ Reelin signalling pathway ⁶⁶ VLDL biosynthesis ⁶⁶ VLDL interactions ⁶⁶ VLDLR internalisation and degradation ⁶⁶	12.23	ABCA1 ANGPTL3 APOA1 APOA2 APOB APOE
5	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁶ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.07	ABCA1 APOA1 APOB APOE
6	Metabolism of fat-soluble vitamins ⁶⁶ Show member pathways Metabolism of vitamin K ⁶⁶ Retinoid metabolism and transport ⁶⁶ The retinoid cycle in cones (daylight vision) ⁶⁶ Visual phototransduction ⁶⁶ Vitamin D (calciferol) metabolism ⁶⁶	12.05	APOA1 APOA2 APOB APOE LPL
7	Binding and Uptake of Ligands by Scavenger Receptors ⁶⁶ Show member pathways Scavenging by Class A Receptors ⁶⁶ Scavenging by Class B Receptors ⁶⁶ Scavenging by Class F Receptors ⁶⁶ Scavenging by Class H Receptors ⁶⁶ Scavenging of heme from plasma ⁶⁶	11.67	APOA1 APOB APOE
8	PPAR signaling pathway ³⁷	11.5	APOA1 APOA2 LPL
9	Statin Pathway ¹ Show member pathways Cholesterol metabolism ³⁷ Composition of Lipid Particles ¹ Statin Pathway, Pharmacodynamics ⁶¹	11.39	ABCA1 ANGPTL3 APOA1 APOA2 APOB APOE
10	amb2 Integrin signaling ¹	11.22	APOB LPA
11	Fat digestion and absorption ³⁷ Show member pathways Trafficking of dietary sterols ⁶⁶	11.2	ABCA1 APOA1 APOB MTTP
12	PPAR Alpha Pathway ¹	10.93	APOA1 APOA2
13	Vitamin digestion and absorption ³⁷	10.87	APOA1 APOB
14	Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF) ²²	10.82	ABCA1 APOA1 APOA2

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GO Terms for Hypolipoproteinemia

Cellular components related to Hypolipoproteinemia according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	Golgi apparatus	GO:0005794	9.97	ABCA1 ANGPTL3 APOE MTTP SAR1B
2	cell surface	GO:0009986	9.86	ABCA1 ANGPTL3 APOA1 LPL
3	endoplasmic reticulum lumen	GO:0005788	9.83	APOA1 APOA2 APOB APOE MTTP
4	early endosome	GO:0005769	9.8	ANGPTL3 APOA1 APOA2 APOB APOE
5	blood microparticle	GO:0072562	9.7	APOA1 APOA2 APOE
6	clathrin-coated endocytic vesicle membrane	GO:0030669	9.55	APOB APOE
7	endoplasmic reticulum exit site	GO:0070971	9.54	APOB SAR1B
8	endocytic vesicle lumen	GO:0071682	9.54	APOA1 APOB APOE
9	spherical high-density lipoprotein particle	GO:0034366	9.51	APOA1 APOA2
10	low-density lipoprotein particle	GO:0034362	9.5	APOA1 APOB APOE
11	discoidal high-density lipoprotein particle	GO:0034365	9.48	APOA1 APOE
12	high-density lipoprotein particle	GO:0034364	9.46	APOA1 APOA2 APOE LCAT
13	intermediate-density lipoprotein particle	GO:0034363	9.43	APOA1 APOB APOE
14	very-low-density lipoprotein particle	GO:0034361	9.35	APOA1 APOA2 APOB APOE LPL
15	chylomicron	GO:0042627	9.02	APOA1 APOA2 APOB APOE LPL
16	extracellular region	GO:0005576	10.06	ANGPTL3 APOA1 APOA2 APOB APOE LCAT
17	extracellular space	GO:0005615	10.04	ANGPTL3 APOA1 APOA2 APOB APOE LCAT

Biological processes related to Hypolipoproteinemia according to GeneCards Suite gene sharing:

(show top 50) (show all 59)

#	Name	GO ID	Score	Top Affiliating Genes
1	steroid metabolic process	GO:0008202	9.98	ABCA1 APOA1 APOB APOE LCAT
2	lipid transport	GO:0006869	9.98	ABCA1 APOA1 APOA2 APOB APOE LPA
3	cellular protein metabolic process	GO:0044267	9.97	APOA1 APOA2 APOB APOE
4	phospholipid metabolic process	GO:0006644	9.93	ANGPTL3 APOA1 LCAT LPL
5	retinoid metabolic process	GO:0001523	9.91	APOA1 APOA2 APOB APOE
6	receptor-mediated endocytosis	GO:0006898	9.9	APOA1 APOB APOE
7	triglyceride metabolic process	GO:0006641	9.89	APOA2 APOE LPL MTTP
8	cholesterol transport	GO:0030301	9.89	ABCA1 APOA1 APOA2 APOB LCAT
9	triglyceride homeostasis	GO:0070328	9.88	ANGPTL3 APOA1 APOE LPL
10	cholesterol efflux	GO:0033344	9.88	ABCA1 APOA1 APOA2 APOB APOE
11	regulation of lipid metabolic process	GO:0019216	9.87	ABCA1 APOA1 APOA2
12	triglyceride catabolic process	GO:0019433	9.87	APOA1 APOB APOE LPL
13	cholesterol metabolic process	GO:0008203	9.87	ABCA1 ANGPTL3 APOA1 APOA2 APOB APOE
14	high-density lipoprotein particle remodeling	GO:0034375	9.86	APOA1 APOA2 APOE LCAT
15	low-density lipoprotein particle remodeling	GO:0034374	9.85	APOA2 APOB APOE LPA
16	reverse cholesterol transport	GO:0043691	9.85	ABCA1 APOA1 APOA2 APOE LCAT
17	high-density lipoprotein particle assembly	GO:0034380	9.84	ABCA1 APOA1 APOA2 APOE
18	phospholipid transport	GO:0015914	9.83	ABCA1 APOA1 MTTP
19	phospholipid efflux	GO:0033700	9.83	ABCA1 APOA1 APOA2 APOE
20	phosphatidylcholine biosynthetic process	GO:0006656	9.81	APOA1 APOA2 LCAT
21	artery morphogenesis	GO:0048844	9.81	ANGPTL3 APOB APOE
22	very-low-density lipoprotein particle remodeling	GO:0034372	9.81	APOA1 APOE LCAT LPL
23	high-density lipoprotein particle clearance	GO:0034384	9.8	APOA1 APOA2 APOE
24	phospholipid homeostasis	GO:0055091	9.79	ABCA1 ANGPTL3 APOA1
25	positive regulation of cholesterol esterification	GO:0010873	9.78	APOA1 APOA2 APOE
26	regulation of Cdc42 protein signal transduction	GO:0032489	9.77	ABCA1 APOA1 APOE
27	chylomicron assembly	GO:0034378	9.77	APOA1 APOA2 APOB APOE MTTP
28	animal organ regeneration	GO:0031100	9.73	APOA1 APOA2
29	cholesterol biosynthetic process	GO:0006695	9.72	APOA1 APOE
30	lipid homeostasis	GO:0055088	9.72	ANGPTL3 APOE
31	lipoprotein transport	GO:0042953	9.72	APOB MTTP
32	lipid storage	GO:0019915	9.72	ANGPTL3 APOA1
33	positive regulation of lipid biosynthetic process	GO:0046889	9.71	APOA1 APOE
34	positive regulation of macrophage derived foam cell differentiation	GO:0010744	9.71	APOB LPL
35	phospholipid catabolic process	GO:0009395	9.71	ANGPTL3 APOA2
36	positive regulation of cholesterol efflux	GO:0010875	9.71	ABCA1 APOE
37	protein lipidation	GO:0006497	9.71	ABCA1 MTTP
38	very-low-density lipoprotein particle assembly	GO:0034379	9.7	APOB MTTP
39	regulation of lipoprotein lipase activity	GO:0051004	9.69	ANGPTL3 LPL
40	chylomicron remnant clearance	GO:0034382	9.69	APOB APOE
41	positive regulation of cholesterol storage	GO:0010886	9.69	APOB LPL
42	positive regulation of lipid catabolic process	GO:0050996	9.68	ANGPTL3 APOA2
43	regulation of cholesterol transport	GO:0032374	9.68	APOA1 APOE
44	negative regulation of cytokine secretion involved in immune response	GO:0002740	9.68	APOA1 APOA2
45	peptidyl-methionine modification	GO:0018206	9.68	APOA1 APOA2
46	very-low-density lipoprotein particle clearance	GO:0034447	9.67	APOB APOE
47	regulation of intestinal cholesterol absorption	GO:0030300	9.67	APOA1 APOA2
48	negative regulation of lipase activity	GO:0060192	9.66	APOA1 APOA2
49	protein oxidation	GO:0018158	9.66	APOA1 APOA2
50	lipoprotein catabolic process	GO:0042159	9.65	APOB APOE

Molecular functions related to Hypolipoproteinemia according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	lipid binding	GO:0008289	9.88	APOA1 APOA2 APOB APOE MTTP
2	heparin binding	GO:0008201	9.8	ANGPTL3 APOB APOE LPA LPL
3	cholesterol binding	GO:0015485	9.67	ABCA1 APOA1 APOA2 APOE
4	phospholipid binding	GO:0005543	9.65	ABCA1 APOA1 APOA2 APOB APOE
5	phospholipid transporter activity	GO:0005548	9.63	ABCA1 APOA1 MTTP
6	high-density lipoprotein particle binding	GO:0008035	9.61	ABCA1 APOA1 APOA2
7	low-density lipoprotein particle receptor binding	GO:0050750	9.56	APOB APOE
8	lipase inhibitor activity	GO:0055102	9.55	APOA1 APOA2
9	lipoprotein particle binding	GO:0071813	9.54	APOA1 APOE
10	apolipoprotein A-I binding	GO:0034186	9.52	ABCA1 LCAT
11	apolipoprotein receptor binding	GO:0034190	9.51	APOA1 APOA2
12	phosphatidylcholine-sterol O-acyltransferase activator activity	GO:0060228	9.5	APOA1 APOA2 APOE
13	high-density lipoprotein particle receptor binding	GO:0070653	9.49	APOA1 APOA2
14	apolipoprotein binding	GO:0034185	9.46	ABCA1 LPA LPL MTTP
15	cholesterol transporter activity	GO:0017127	9.35	ABCA1 APOA1 APOA2 APOB APOE
16	lipid transporter activity	GO:0005319	9.1	ABCA1 APOA1 APOA2 APOB APOE MTTP

Sources

Sources for Hypolipoproteinemia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia