MCID: HYP024
MIFTS: 54

Hypoparathyroidism

Categories: Blood diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Hypoparathyroidism

MalaCards integrated aliases for Hypoparathyroidism:

Name: Hypoparathyroidism 12 76 53 37 29 55 44 15 73
Hypoparathyroidism, Idiopathic 53
Parathyroid, Underactivity of 53

Classifications:



External Ids:

Disease Ontology 12 DOID:11199
ICD10 33 E20 E20.9 E20.0
ICD9CM 35 252.1
MeSH 44 D007011
NCIt 50 C78350
SNOMED-CT 68 36976004
KEGG 37 H01862
UMLS 73 C0020626

Summaries for Hypoparathyroidism

NIH Rare Diseases : 53 Hypoparathyroidism is is an endocrine disorder in which the parathyroid glands in the neck do not produce enough parathyroid hormone (PTH). Common signs and symptoms include abdominal pain, brittle nails, cataracts, dry hair and skin, muscle cramps, tetany, pain in the face, legs, and feet, seizures, tingling sensation, and weakened tooth enamel (in children). It may be caused by injury to the parathyroid glands (e.g., during surgery). Other causes, include low blood magnesium levels, a side effect of radioactive iodine treatment for hyperthyroidism, metabolic alkalosis, DiGeorge syndrome, and type I polyglandular autoimmune syndrome. The goal of treatment is to restore the calcium and mineral balance in the body.

MalaCards based summary : Hypoparathyroidism, also known as hypoparathyroidism, idiopathic, is related to hypoparathyroidism, familial isolated and hypoparathyroidism-retardation-dysmorphism syndrome. An important gene associated with Hypoparathyroidism is GCM2 (Glial Cells Missing Homolog 2), and among its related pathways/superpathways are G alpha (s) signalling events and Endochondral Ossification. The drugs Betamethasone and Calcium Carbonate have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and kidney, and related phenotypes are endocrine/exocrine gland and digestive/alimentary

Disease Ontology : 12 A parathyroid gland disease characterized by decreased function of parathyroid glands with underproduction of parathyroid hormone (PTH), leading to abnormally low ionized calcium levels in the blood.

Wikipedia : 76 Hypoparathyroidism is decreased function of the parathyroid glands with underproduction of parathyroid... more...

Related Diseases for Hypoparathyroidism

Diseases in the Hypoparathyroidism family:

Secondary Hypoparathyroidism Due to Impaired Parathormon Secretion Autoimmune Hypoparathyroidism

Diseases related to Hypoparathyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 305)
# Related Disease Score Top Affiliating Genes
1 hypoparathyroidism, familial isolated 34.1 AIRE CASR GCM2 PTH
2 hypoparathyroidism-retardation-dysmorphism syndrome 34.1 FAM111A PTH TBCE
3 hypocalcemia, autosomal dominant 1 33.2 CASR FGF23 GCM2 PTH
4 autoimmune polyendocrine syndrome type 1 33.1 AIRE CASR
5 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 33.0 AIRE CASR
6 pseudohypoparathyroidism 31.9 BGLAP PTH PTH1R PTHLH
7 kenny-caffey syndrome 30.3 FAM111A TBCE
8 autoimmune polyendocrine syndrome 29.9 AIRE CASR
9 familial hypocalciuric hypercalcemia 29.8 CASR PTH SPG7
10 hyperphosphatemia 29.8 CASR FGF23 GCM2 PTH
11 hypophosphatemia 29.7 BGLAP FGF23 PTH
12 hyperparathyroidism 29.6 BGLAP CASR FGF23 GCM2 PTH PTHLH
13 osteomalacia 29.6 BGLAP CASR FGF23 PTH
14 calciphylaxis 29.5 CASR FGF23 PTH
15 pseudohypoparathyroidism, type ib 29.5 BGLAP PTH PTH1R PTHLH
16 secondary hyperparathyroidism of renal origin 29.4 BGLAP CASR FGF23 PTH
17 rickets 29.3 BGLAP FGF23 PTH
18 osteoporosis 28.7 ALPP BGLAP CASR FGF23 PTH PTH1R
19 bone disease 28.6 ALPP BGLAP CASR FGF23 PTH PTH1R
20 primary hyperparathyroidism 28.5 ALPP BGLAP CASR FGF23 GCM2 PTH
21 hypoparathyroidism, sensorineural deafness, and renal disease 12.7
22 hypoparathyroidism-intellectual disability-dysmorphism syndrome 12.5
23 autoimmune hypoparathyroidism 12.3
24 secondary hypoparathyroidism due to impaired parathormon secretion 12.1
25 familial isolated hypoparathyroidism due to agenesis of parathyroid gland 12.1
26 hypoparathyroidism, x-linked 12.1
27 lymphedema-hypoparathyroidism syndrome 12.1
28 dahlberg borer newcomer syndrome 11.8
29 pseudopseudohypoparathyroidism 11.3
30 kearns-sayre syndrome 11.3
31 digeorge syndrome 11.3
32 pseudohypoparathyroidism, type ic 11.3
33 kenny-caffey syndrome, type 2 11.3
34 basal ganglia calcification, idiopathic, childhood-onset 11.0
35 kenny-caffey syndrome, type 1 11.0
36 ossification of the posterior longitudinal ligament of spine 11.0
37 primary hypomagnesemia 11.0
38 renal dysplasia 10.4
39 basal ganglia calcification 10.3
40 hypothyroidism 10.3
41 chief cell adenoma 10.2 GCM2 PTH
42 hypocalciuric hypercalcemia, familial, type i 10.2 CASR PTH
43 hypocalciuric hypercalcemia, familial, type ii 10.2 CASR PTH
44 water-clear cell adenoma 10.2 GATA3 PTH
45 thalassemia 10.2
46 pseudopapilledema 10.2 GATA3 TBCE
47 thyroiditis 10.2
48 sclerosing hepatic carcinoma 10.2 PTH PTHLH
49 invasive malignant thymoma 10.2 PTH PTHLH
50 clear cell adenoma 10.2 PTH PTHLH

Comorbidity relations with Hypoparathyroidism via Phenotypic Disease Network (PDN):


Acute Cystitis Chronic Kidney Failure
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Hyperparathyroidism
Hypertension, Essential Hypothyroidism
Postsurgical Hypothyroidism

Graphical network of the top 20 diseases related to Hypoparathyroidism:



Diseases related to Hypoparathyroidism

Symptoms & Phenotypes for Hypoparathyroidism

MGI Mouse Phenotypes related to Hypoparathyroidism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.76 AIRE CASR FGF23 GATA3 GCM2 PTH
2 digestive/alimentary MP:0005381 9.73 AIRE CASR FGF23 GATA3 PTH1R PTHLH
3 craniofacial MP:0005382 9.72 GATA3 GCM2 PTH PTH1R PTHLH
4 mortality/aging MP:0010768 9.61 AIRE CASR FGF23 GATA3 GCM2 PTH
5 skeleton MP:0005390 9.23 CASR FGF23 GATA3 GCM2 PTH PTH1R

Drugs & Therapeutics for Hypoparathyroidism

Drugs for Hypoparathyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 156)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
2
Calcium Carbonate Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 471-34-1
3
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
4
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
5
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
6
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Not Applicable 50-14-6 5280793
7
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 3 67-97-0 5280795 6221
8
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 1406-16-2
9
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
10 Anti-Asthmatic Agents Phase 4
11 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
12 Betamethasone acetate Phase 4
13 Betamethasone benzoate Phase 4
14 Betamethasone Valerate Phase 4 2152-44-5
15 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
16 Anti-Inflammatory Agents Phase 4,Phase 1,Phase 2
17 glucocorticoids Phase 4,Phase 1,Phase 2
18 Respiratory System Agents Phase 4
19 Betamethasone-17,21-dipropionate Phase 4
20 Betamethasone sodium phosphate Phase 4
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
22 Trace Elements Phase 4,Phase 3,Phase 2,Not Applicable
23 Ergocalciferols Phase 4,Phase 3,Not Applicable
24 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
25 Micronutrients Phase 4,Phase 3,Phase 2,Not Applicable
26 Vitamin D2 Phase 4,Phase 3,Not Applicable
27 Calciferol Phase 4,Phase 3,Phase 2,Not Applicable
28 Vitamins Phase 4,Phase 2,Phase 3,Not Applicable
29 Calcium, Dietary Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
30 Anticoagulants Phase 4,Not Applicable
31 Calcium Supplement Phase 4,Phase 1,Phase 2
32 Chelating Agents Phase 4,Phase 2
33 Anti-Ulcer Agents Phase 4,Phase 1,Phase 2,Not Applicable
34 Citrate Phase 4
35 Antacids Phase 4,Phase 1,Phase 2,Not Applicable
36 Gastrointestinal Agents Phase 4,Phase 1,Phase 2,Not Applicable
37 Central Nervous System Stimulants Phase 4
38 Psychotropic Drugs Phase 4
39 Dopamine Agents Phase 4
40 Dopamine Antagonists Phase 4
41 Central Nervous System Depressants Phase 4,Phase 1,Phase 2
42 Antipsychotic Agents Phase 4
43 Serotonin Agents Phase 4
44 Neurotransmitter Agents Phase 4,Phase 1,Phase 2
45 Serotonin Antagonists Phase 4
46 Neurotransmitter Uptake Inhibitors Phase 4
47 Dopamine Uptake Inhibitors Phase 4
48 Tranquilizing Agents Phase 4
49
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
50
Tocopherol Approved, Investigational Phase 2, Phase 3 1406-66-2 14986

Interventional clinical trials:

(show top 50) (show all 115)
# Name Status NCT ID Phase Drugs
1 Steroids in the Postoperative Transient Hypoparathyroidism Total Thyroidectomy Unknown status NCT02652884 Phase 4 phosphate and betamethasone acetate, 2 mL.;saline 0.9% NaCl
2 Vitamin D Deficiency and Postoperative Hypocalcemia Unknown status NCT01632514 Phase 4 Cholecalciferol
3 Does Treatment of Hypovitaminosis D Increase Calcium Absorption? Completed NCT00581828 Phase 4 Vitamin D
4 Study of the Effect of Recombinant Human Parathyroid Hormone [rhPTH(1-84)] on Symptoms Improvement and Metabolic Control Among Adults With Hypoparathyroidism Recruiting NCT03324880 Phase 4
5 The Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome Recruiting NCT00768820 Phase 4 methylphenidate, fluoxetin, risperidone
6 A Study of Extended Use of Recombinant Human Parathyroid Hormone (rhPTH(1-84)) in Hypoparathyroidism Active, not recruiting NCT02910466 Phase 4 rhPTH(1-84)
7 Efficacy of Calcium Citrate Versus Calcium Carbonate in Maintaining Normal Serum Calcium Level and Changing Quality of Life in Patients With Chronic Hypoparathyroidism Not yet recruiting NCT03425747 Phase 4 Calcium Carbonate;Calcium Citrate
8 Medico-economic Evaluation Comparing the Use of Ultrasonic Scissors to the Conventional Techniques of Haemostasis in Thyroid Surgery by Cervicotomy Unknown status NCT01551914 Phase 3
9 Indicated Prevention With Long-chain Polyunsaturated Omega-3 Fatty Acids in Patients With 22q11 Microdeletion Syndrome. Unknown status NCT02070211 Phase 2, Phase 3
10 Study of Safety and Efficacy of a rhPTH[1-84] of Fixed Doses of 25 and 50 mcg in Adults With Hypoparathyroidism (RELAY) Completed NCT01268098 Phase 3 NPSP558
11 Use of NPSP558 in the Treatment of Hypoparathyroidism Completed NCT00732615 Phase 3 Placebo;NPSP558
12 A Study to Investigate the Safety and Tolerability of NPSP558, for the Treatment of Adults With Hypoparathyroidism - A Clinical Extension Study in Hungary Completed NCT01455181 Phase 3 NPSP558
13 A Open-label Study Investigating the Safety and Tolerability of NPSP558, a Recombinant Human Parathyroid Hormone (rhPTH [1-84]), for the Treatment of Adults With Hypoparathyroidism - A Clinical Extension Study (RACE) Completed NCT01297309 Phase 3 NPSP558
14 Bone Properties in Hypoparathyroidism: Effects of PTH Completed NCT00473265 Phase 2, Phase 3 PTH
15 Safety and Efficacy Study of rhPTH(1-84) in Subjects With Hypoparathyroidism Recruiting NCT03364738 Phase 3
16 ADD-ON Study to Existing Hypoparathyroidism Studies Active, not recruiting NCT00856401 Phase 3 PTH1-84 in parent study
17 HEXT (Hypo EXTended): Effect of PTH on Skeleton in Hypoparathyroidism Active, not recruiting NCT01199614 Phase 3 open-label PTH(1-84)
18 Randomized Controlled Trial of Neo-adjuvant Progesterone and Vitamin D3 in Women With Large Operable Breast Cancer and Locally Advanced Breast Cancer Active, not recruiting NCT01608451 Phase 3 Cholecalciferol;Inj. Progesterone
19 Effects of PTH Replacement on Bone in Hypoparathyroidism Terminated NCT00395538 Phase 3 PTH 1-34
20 A Study Comparing Amorphous Calcium Carbonate (ACC) Versus Crystalline Calcium CCS) in Hypoparathyroidism Patients Completed NCT01815021 Phase 1, Phase 2
21 Treatment of Hypoparathyroidism With Subcutaneous PTH (1-84) Injections: Effects on Muscle Function and Quality of Life Completed NCT00730210 Phase 2 a: PTH (1-84);b:placebo
22 A Pilot Study to Assess the Safety and Efficacy of Oral PTH (1-34) in the Treatment of Hypoparathyroidism Completed NCT02152228 Phase 2 EnteraBio's Oral Parathyroid Hormone (1-34)
23 Treatment of Hypoparathyroidism With Synthetic Human Parathyroid Hormone 1-34 Completed NCT00001304 Phase 2 Synthetic Human Parathyroid Hormone 1-34;Calcitriol & Calcium
24 Intra-operative Infra-red Fluorescent Imaging in Thyroid and Parathyroid Surgery Completed NCT02089542 Phase 1, Phase 2
25 A Study to Determine the Effects of NPSP795 on the Calcium-sensing Receptor in Subjects With Autosomal Dominant Hypocalcemia as Measured by PTH Levels and Blood Calcium Concentrations Completed NCT02204579 Phase 2 NPSP795
26 Recombinant Human rhPTH(1-34) VS Association Alfacalcidol/Hydrochlorothiazide in Severe Primary Hypoparathyroidism Recruiting NCT02824718 Phase 2 Teriparatide;Thiazide;Potassium sparing diuretic;Alfacalcidol
27 Central Neck Dissection in Patients With Clinical Node Negative Thyroid Cancer Recruiting NCT02138214 Phase 2
28 Immune Disorder HSCT Protocol Recruiting NCT01821781 Phase 2 Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan
29 Oral PTH(1-34) PK and PD Study in Patients With Hypoparathyroidism Active, not recruiting NCT03516773 Phase 2 EB612 (EBP05);NATPARA/NATPAR
30 Phase I/II Thymus Transplantation With Immunosuppression #950 Active, not recruiting NCT00579527 Phase 1, Phase 2 Rabbit anti-thymocyte globulin;Cyclosporine;Tacrolimus;Methylprednisolone or Prednisolone;Daclizumab;Mycophenolate mofetil
31 Thymus Transplantation Dose in DiGeorge #932 Active, not recruiting NCT00576836 Phase 2
32 Total Thyroidectomy With and Without Prophylactic Central Neck Lymph Node Dissection in People With Low-risk Papillary Thyroid Cancer Active, not recruiting NCT02408887 Phase 2
33 Thymus Transplantation in DiGeorge Syndrome #668 Active, not recruiting NCT00576407 Phase 2
34 Intralesional Sodium Thiosulfate for Ectopic Calcifications or Ossifications. A Pilot Study Not yet recruiting NCT03582800 Phase 2 STS
35 Teriparatide for Postsurgical Hypoparathyroidism Terminated NCT01171690 Phase 2 Teriparatide
36 Metyrosine (Demser®) for the Treatment of Psychotic Disorders in Patients With Velocardiofacial Syndrome Terminated NCT01127503 Phase 2 Metyrosine;Placebo
37 Study of rhPTH(1-84) in Japanese Healthy Subjects Compared With Matched Caucasian Healthy Adult Subjects Completed NCT03150108 Phase 1 rhPTH(1-84);rhPTH(1-84);rhPTH(1-84)
38 Safety and Efficacy Study of NFC-1 in Subjects Aged 12-17 Years With 22q11.2DS & Associated Neuropsychiatric Conditions Completed NCT02895906 Phase 1 NFC-1
39 Study to Assess the Blood Concentrations and Actions of Recombinant Human Parathyroid Hormone (rhPTH [1-84]) When Given Once and Twice Daily to Participants With Hypoparathyroidism Recruiting NCT02781844 Phase 1 25mcg rhPTH(1-84);50mcg rhPTH(1-84);100mcg rhPTH(1-84)
40 Fluorescence Imaging in Head and Neck Cancer Recruiting NCT03297957 Phase 1 IC-GREEN
41 Precision Thyroid Cancer Surgery With Molecular Fluorescent Guided Imaging Recruiting NCT03470259 Phase 1 IV adminstration of EMI-137
42 Parathyroid and Thymus Transplantation in DiGeorge #931 Active, not recruiting NCT00566488 Phase 1
43 Thymus Transplantation With Immunosuppression Active, not recruiting NCT00579709 Phase 1
44 Serum-Free Thymus Transplantation in DiGeorge Anomaly Terminated NCT00849888 Phase 1
45 Vitamin D Levels and Postoperative Hypocalcemia After Total Thyroidectomy Unknown status NCT01039714
46 Parathyroid Auto-transplantation: Prospective Randomized Trial of the Personalized Site Unknown status NCT02906748 Not Applicable
47 Comparative Analysis Between Bipolar Device and Conventional Tie & Suture Technique in Thyroidectomy Unknown status NCT02140476 Not Applicable
48 Prenatal Examination of Deletion 22q11 Syndrome : Thymic Dysgenesis THYMI Study Unknown status NCT02890472
49 Non-Invasive Chromosomal Evaluation of 22q11.2 Unknown status NCT02541058
50 Genetic Modifiers for 22q11.2 Syndrome Unknown status NCT00916955

Search NIH Clinical Center for Hypoparathyroidism

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: hypoparathyroidism

Genetic Tests for Hypoparathyroidism

Genetic tests related to Hypoparathyroidism:

# Genetic test Affiliating Genes
1 Hypoparathyroidism 29

Anatomical Context for Hypoparathyroidism

MalaCards organs/tissues related to Hypoparathyroidism:

41
Thyroid, Bone, Kidney, Testes, Skin, Thymus, Brain

Publications for Hypoparathyroidism

Articles related to Hypoparathyroidism:

(show top 50) (show all 1120)
# Title Authors Year
1
Teriparatide Replacement Therapy for Hypoparathyroidism During Treatment With Lenvatinib for Advanced Thyroid Cancer: A Case Report. ( 29867775 )
2018
2
Quality of life in hypoparathyroidism. ( 29181618 )
2018
3
Self-report of psychological symptoms in hypoparathyroidism patients on conventional therapy. ( 29791658 )
2018
4
Under-recognized Hypoparathyroidism in Thalassemia. ( 29726397 )
2018
5
Patients' views about parathyroid transplantation for post-thyroidectomy hypoparathyroidism. ( 29971614 )
2018
6
The Effects of Long-term Administration of rhPTH(1-84) in Hypoparathyroidism by Bone Histomorphometry. ( 29972871 )
2018
7
Primary hypoparathyroidism presenting as basal ganglia calcification secondary to extreme hypocalcemia. ( 29383229 )
2018
8
Isolated ligamentum flavum ossification in primary hypoparathyroidism. ( 29399376 )
2018
9
Dental Findings in Patients With Non-surgical Hypoparathyroidism and Pseudohypoparathyroidism: A Systematic Review. ( 29971010 )
2018
10
Hypocitraturia Is an Untoward Side Effect of Synthetic Human Parathyroid Hormone (hPTH) 1-34 Therapy in Hypoparathyroidism That May Increase Renal Morbidity. ( 29878514 )
2018
11
Successful pregnancies and reduced treatment requirement while breast feeding in a patient with congenital hypoparathyroidism due to homozygous c.68C>A null parathyroid hormone gene mutation. ( 29804071 )
2018
12
MILK-ALKALI SYNDROME (MAS) as a complication of the treatment of hypoparathyroidism. ( 29442351 )
2018
13
Screening and management of postoperative hypoparathyroidism-induced hypocalcemia in thyroidectomized patients in the endocrine ward compared with the surgical ward. ( 29940689 )
2018
14
Acute Onset of Quadriplegia Secondary to Hypoparathyroidism: Mimicker of AMAN Variant of GBS. ( 29482695 )
2018
15
An ICET- A survey on Hypoparathyroidism in Patients with Thalassaemia Major and Intermedia: A preliminary report. ( 29350657 )
2018
16
Hypoparathyroidism Causing Seizures: When Epilepsy Does Not Fit. ( 29808096 )
2018
17
Health-related quality of life in patients with nonsurgical hypoparathyroidism and pseudohypoparathyroidism. ( 29520810 )
2018
18
Hypothyroidism and Hypoparathyroidism in Thalassemia Major Patients: A Study in Sistan and Baluchestan Province, Iran. ( 29868126 )
2018
19
Hypoparathyroidism concomitant with macrothrombocytopenia in an elderly woman with 22q11.2 deletion syndrome. ( 29851532 )
2018
20
Development of a Novel Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist (CH5447240), a Potent and Orally Available Small Molecule for Treatment of Hypoparathyroidism. ( 29932656 )
2018
21
Does the number of parathyroid glands autotransplanted affect the incidence of hypoparathyroidism and recovery of parathyroid function? ( 29398031 )
2018
22
Homozygous calcium-sensing receptor polymorphism R544Q presents as hypocalcemic hypoparathyroidism. ( 29846619 )
2018
23
Effect of autotransplantation of a parathyroid gland on hypoparathyroidism after total thyroidectomy. ( 29301864 )
2018
24
Postoperative hypoparathyroidism after total thyroidectomy for thyroid cancer. ( 29747960 )
2018
25
Hypoparathyroidism: is it that easy to treat? ( 29876797 )
2018
26
Autoimmune-Related Primary Hypoparathyroidism Possibly Induced by the Administration of Pembrolizumab: A Case Report. ( 29906213 )
2018
27
Lung squamous cell carcinoma associated with hypoparathyroidism with sensorineural deafness and renal dysplasia syndrome: a case report. ( 29593425 )
2018
28
De novo a novel variant of CaSR gene in a neonate with congenital hypoparathyroidism. ( 29969884 )
2018
29
The hypoparathyroidism-deafness-renal dysplasia syndrome: A case report. ( 29398643 )
2018
30
Immunosuppressive therapy of autoimmune hypoparathyroidism in a patient with activating autoantibodies against the calcium-sensing receptor. ( 30358904 )
2018
31
Cardiovascular Autonomic Neuropathy as a New Complication of Postsurgical Chronic Hypoparathyroidism. ( 30395692 )
2018
32
Trabecular bone score and bone mineral density in patients with postsurgical hypoparathyroidism after total thyroidectomy for differentiated thyroid carcinoma. ( 30554726 )
2018
33
Presumptive Glucocorticoid-Induced Refractory Hypocalcemia in a Dog with Idiopathic Immune-Mediated Hypoparathyroidism, Thrombocytopenia, and Hemolytic Anemia. ( 30427709 )
2018
34
Intracranial Calcification Due to Hypoparathyroidism. ( 29355508 )
2018
35
Permanent Hypoparathyroidism After Total Thyroidectomy in Children: Results from a National Registry. ( 29470698 )
2018
36
Misdiagnosis of idiopathic hypoparathyroidism: A case report and literature review. ( 29489687 )
2018
37
HypoparaNet: A Database of Chronic Hypoparathyroidism Based on Expert Medical-Surgical Centers in Italy. ( 29511787 )
2018
38
Preventing hypoparathyroidism after total thyroidectomy. ( 29512348 )
2018
39
Prevalence of Chronic Hypoparathyroidism in a Mediterranean Region as Estimated by the Analysis of Anonymous Healthcare Database. ( 29516129 )
2018
40
Efficacy and safety of long-term management of patients with chronic post-surgical hypoparathyroidism. ( 29516386 )
2018
41
Iatrogenic hypoparathyroidism after surgery for retrosternal goitre. A single centre retrospective analysis. ( 29595868 )
2018
42
Current treatment of hypoparathyroidism: Theory versus reality waiting guidelines for children and adolescents. ( 29633734 )
2018
43
Comparison of functional outcomes after total thyroidectomy and completion thyroidectomy: Hypoparathyroidism and postoperative complications. ( 29636205 )
2018
44
Mortality in patients with permanent hypoparathyroidism after total thyroidectomy. ( 29663312 )
2018
45
Hypoparathyroidism in Total Thyroidectomy due to Benign Thyroid Diseases. ( 29685599 )
2018
46
Diagnosis and treatment of hypoparathyroidism: a position statement from the Brazilian Society of Endocrinology and Metabolism. ( 29694629 )
2018
47
SURGICAL PREVENTION AND TREATMENT OF POSTOPERATIVE HYPOPARATHYROIDISM IN PATIENTS OPERATED ON THYROID GLAND. ( 29697378 )
2018
48
American Thyroid Association Statement on Postoperative Hypoparathyroidism: Diagnosis, Prevention, and Management in Adults. ( 29848235 )
2018
49
Does PTH Replacement Therapy Improve Quality of Life in Patients With Chronic Hypoparathyroidism? ( 29897557 )
2018
50
Correction: Hypoparathyroidism in pregnancy. ( 30021727 )
2018

Variations for Hypoparathyroidism

Expression for Hypoparathyroidism

Search GEO for disease gene expression data for Hypoparathyroidism.

Pathways for Hypoparathyroidism

GO Terms for Hypoparathyroidism

Biological processes related to Hypoparathyroidism according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.71 BGLAP GATA3 PTH
2 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.7 PTH PTH1R PTHLH
3 ossification GO:0001503 9.69 BGLAP CASR PTH1R
4 skeletal system development GO:0001501 9.62 BGLAP PTH PTH1R PTHLH
5 cell maturation GO:0048469 9.58 GATA3 PTH1R
6 bone resorption GO:0045453 9.58 PTH PTH1R
7 regulation of bone mineralization GO:0030500 9.57 BGLAP FGF23
8 response to vitamin D GO:0033280 9.56 BGLAP PTH
9 cellular calcium ion homeostasis GO:0006874 9.56 CASR GCM2 PTH PTH1R
10 negative regulation of chondrocyte differentiation GO:0032331 9.55 PTH PTHLH
11 cellular phosphate ion homeostasis GO:0030643 9.49 FGF23 GCM2
12 positive regulation of inositol phosphate biosynthetic process GO:0060732 9.48 PTH PTH1R
13 parathyroid gland development GO:0060017 9.46 GATA3 GCM2
14 phosphate ion homeostasis GO:0055062 9.43 FGF23 PTH
15 response to fibroblast growth factor GO:0071774 9.4 CASR PTH
16 cAMP metabolic process GO:0046058 9.37 PTH PTHLH
17 osteoblast development GO:0002076 9.33 BGLAP PTH1R PTHLH
18 cellular response to vitamin D GO:0071305 9.13 BGLAP CASR FGF23
19 bone mineralization GO:0030282 8.92 BGLAP PTH PTH1R PTHLH

Molecular functions related to Hypoparathyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide hormone receptor binding GO:0051428 8.62 PTH PTHLH

Sources for Hypoparathyroidism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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