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MCID: HYP017
MIFTS: 46

Hypophosphatemia

Categories: Metabolic diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Hypophosphatemia

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MalaCards integrated aliases for Hypophosphatemia:

Name: Hypophosphatemia 12 29 55 15 73

Classifications:

MalaCards categories:
Global: Metabolic diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0050336
UMLS 73 C0085682
Sources

Summaries for Hypophosphatemia

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MalaCards based summary : Hypophosphatemia is related to hereditary hypophosphatemic rickets and hypophosphatemic rickets, autosomal dominant. An important gene associated with Hypophosphatemia is FGF23 (Fibroblast Growth Factor 23), and among its related pathways/superpathways are Parathyroid hormone synthesis, secretion and action and FGF signaling pathway. The drugs Insulin Glargine and Zinc have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and liver, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 76 Hypophosphatemia is an electrolyte disturbance in which there is an abnormally low level of phosphate in... more...

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Related Diseases for Hypophosphatemia

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Diseases related to Hypophosphatemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 180)
# Related Disease Score Top Affiliating Genes
1 hereditary hypophosphatemic rickets 33.5 SLC34A1 SLC34A3
2 hypophosphatemic rickets, autosomal dominant 32.4 FGF23 PHEX SFRP4 SLC34A3
3 metaphyseal chondrodysplasia, jansen type 31.4 FGF23 PTH
4 autosomal recessive hypophosphatemic rickets 31.1 DMP1 ENPP1 FGF23 PHEX
5 oncogenic osteomalacia 30.6 DMP1 FGF23 PHEX PTH SFRP4
6 hypophosphatemic rickets, x-linked dominant 30.5 DMP1 FGF23 PHEX PTH SFRP4 SLC34A1
7 enthesopathy 30.5 DMP1 FGF23 PHEX
8 fanconi syndrome 30.3 CLCN5 SLC34A1
9 nephrolithiasis 30.1 CLCN5 SLC34A1 SLC34A3
10 nephrolithiasis, calcium oxalate 29.9 CLCN5 SLC34A1
11 mccune-albright syndrome 29.8 BGLAP FGF23
12 arterial calcification of infancy 29.8 ENPP1 FGF23 PHEX
13 raine syndrome 29.6 DMP1 FAM20C FGF23
14 fibrous dysplasia 29.5 BGLAP FGF23
15 hyperphosphatemia 29.4 FGF23 PHEX PTH SLC34A1
16 hyperparathyroidism 29.2 BGLAP FGF23 PHEX PTH
17 secondary hyperparathyroidism of renal origin 29.1 BGLAP FGF23 PTH
18 osteomalacia 29.1 BGLAP DMP1 FGF23 PHEX SFRP4
19 hypoparathyroidism 29.1 BGLAP FGF23 PTH
20 primary hyperparathyroidism 29.0 BGLAP FGF23 PTH
21 hypophosphatasia 28.8 DSPP ENPP1 PHEX
22 osteoporosis 28.7 BGLAP FGF23 PTH SLC34A1
23 bone disease 28.7 BGLAP FGF23 PTH SLC34A3
24 hypophosphatemic rickets with hypercalciuria, hereditary 28.3 DMP1 ENPP1 FGF23 PHEX PTH SFRP4
25 hypophosphatemic rickets, x-linked recessive 27.8 CLCN5 DMP1 DSPP ENPP1 FGF23 PHEX
26 rickets 26.5 BGLAP CLCN5 DMP1 ENPP1 FGF23 PHEX
27 cutaneous-skeletal hypophosphatemia syndrome 12.2
28 hypophosphatemia, renal, with intracerebral calcifications 11.9
29 dominant hypophosphatemia with nephrolithiasis or osteoporosis 11.9
30 nephrolithiasis/osteoporosis, hypophosphatemic, 1 11.6
31 hypophosphatemic rickets, autosomal recessive, 1 11.6
32 hypophosphatemic rickets, autosomal recessive, 2 11.4
33 vitamin d hydroxylation-deficient rickets, type 1a 11.3
34 panostotic fibrous dysplasia 11.2
35 thyrotoxic periodic paralysis 11.1
36 exostoses, multiple, type i 10.8
37 fanconi renotubular syndrome 1 10.8
38 tumoral calcinosis, hyperphosphatemic, familial, 1 10.8
39 dent disease 1 10.8
40 lowe oculocerebrorenal syndrome 10.8
41 nephrolithiasis/osteoporosis, hypophosphatemic, 2 10.8
42 tumoral calcinosis, hyperphosphatemic, familial, 2 10.8
43 tumoral calcinosis, hyperphosphatemic, familial, 3 10.8
44 opsismodysplasia 10.7 FGF23 PHEX
45 familial tumoral calcinosis 10.7 FGF23 PHEX
46 hypercalciuria, absorptive, 2 10.5 CLCN5 SLC34A3
47 hypervitaminosis d 10.3 FGF23 PTH
48 aminoaciduria 10.3 CLCN5 SLC34A1
49 calciphylaxis 10.3 FGF23 PTH
50 calcinosis 10.3 ENPP1 FGF23 PHEX

Graphical network of the top 20 diseases related to Hypophosphatemia:



Diseases related to Hypophosphatemia
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Symptoms & Phenotypes for Hypophosphatemia

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MGI Mouse Phenotypes related to Hypophosphatemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.02 SLC34A1 FAM20C SLC34A3 FGF23 PHEX CLCN5
2 homeostasis/metabolism MP:0005376 9.96 SLC34A1 FAM20C SLC34A3 FGF23 PHEX CLCN5
3 craniofacial MP:0005382 9.77 FAM20C PHEX CLCN5 PTH DMP1
4 limbs/digits/tail MP:0005371 9.63 FAM20C FGF23 PHEX PTH DMP1 SFRP4
5 renal/urinary system MP:0005367 9.61 FAM20C SLC34A3 FGF23 PHEX CLCN5 DMP1
6 skeleton MP:0005390 9.32 SLC34A1 FAM20C SLC34A3 FGF23 PHEX CLCN5
Sources

Drugs & Therapeutics for Hypophosphatemia

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Drugs for Hypophosphatemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 155)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Insulin Glargine Approved Phase 4 160337-95-1
2
Zinc Approved, Investigational Phase 4 7440-66-6 23994
3
Iron Approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 7439-89-6 23925
4 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
5 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1,Not Applicable
6 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
7 Chelating Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
8 Locust bean gum Phase 4
9 Polystyrene sulfonic acid Phase 4
10 Hypoglycemic Agents Phase 4
11 insulin Phase 4
12 Insulin, Globin Zinc Phase 4
13 Ferric Compounds Phase 4,Phase 3,Phase 2
14 Hematinics Phase 4,Phase 3,Phase 2,Not Applicable
15 Brewer's Yeast Nutraceutical Phase 4
16
Sorafenib Approved, Investigational Phase 3,Phase 1 284461-73-0 216239 406563
17
Emtricitabine Approved, Investigational Phase 3 143491-57-0 60877
18
Lopinavir Approved Phase 3 192725-17-0 92727
19
Ritonavir Approved, Investigational Phase 3 155213-67-5 392622
20
Axitinib Approved, Investigational Phase 3 319460-85-0 6450551
21
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
22
Cisplatin Approved Phase 3,Phase 2 15663-27-1 84093 441203 2767
23
Crizotinib Approved Phase 3,Phase 1 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
24
Pemetrexed Approved, Investigational Phase 3,Phase 2 150399-23-8, 137281-23-3 446556 60843
25
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3,Not Applicable 1406-16-2
26
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
27
Ergocalciferol Approved, Nutraceutical Phase 3,Not Applicable 50-14-6 5280793
28
leucovorin Approved, Nutraceutical Phase 3,Phase 2 58-05-9 143 6006
29 Hormone Antagonists Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
30 Hormones Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
32 Vitamins Phase 3,Phase 1,Not Applicable
33 Calcimimetic Agents Phase 3,Phase 1,Not Applicable
34 Cinacalcet Hydrochloride Phase 3,Phase 1,Not Applicable
35 Protein Kinase Inhibitors Phase 3,Phase 2,Phase 1
36 Vitamin B Complex Phase 3,Phase 2,Phase 1
37 Mitogens Phase 3,Phase 2,Phase 1,Not Applicable
38 Bone Density Conservation Agents Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
39 Ergocalciferols Phase 3,Not Applicable
40 Calcium, Dietary Phase 3,Phase 2,Phase 1,Early Phase 1
41 Anti-HIV Agents Phase 3,Phase 2
42 Anti-Infective Agents Phase 3,Phase 2,Phase 1
43 Anti-Retroviral Agents Phase 3,Phase 2
44 Antiviral Agents Phase 3,Phase 2,Phase 1
45 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 3
46 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
47 Reverse Transcriptase Inhibitors Phase 3,Phase 2
48
Tenofovir Phase 3,Phase 2 147127-20-6 464205
49 Atazanavir Sulfate Phase 3
50 Cytochrome P-450 CYP3A Inhibitors Phase 3

Interventional clinical trials:

(show top 50) (show all 85)
# Name Status NCT ID Phase Drugs
1 The Effect of a Diet Based on Low Sodium and Slowly Absorbed Carbohydrates on the Incidence of Refeeding Syndrome in Patients With Head and Neck Cancer Unknown status NCT01845922 Phase 4
2 Efficacy of Sodium Polystyrene Sulfonate in the Treatment of Hyperkaliemia in Pre-dialysis Patients Completed NCT02065076 Phase 4 Sodium polystyrene sulfonate;Lactose with carob gum
3 Insulin in Total Parenteral Nutrition Completed NCT02706119 Phase 4 Subcutaneous glargine insulin;Regular insulin added to TPN bag
4 A Study Comparing the Iron Substitution With the Medicinal Products Ferinject or Monofer Recruiting NCT02905539 Phase 4 Iron Isomaltoside 1000;Ferric Carboxymaltose
5 A Trial Comparing the Incidence of Hypophosphatemia in Relation to Treatment With Iron Isomaltoside and Ferric Carboxymaltose in Subjects With Iron Deficiency Anaemia Due to Inflammatory Bowel Disease Not yet recruiting NCT03466983 Phase 4 Iron Isomaltoside;Ferric Carboxymaltose
6 Effectiveness of Paricalcitol in Reducing Parathyroid Hormone (PTH) Levels in X-linked Hypophosphatemic Rickets Completed NCT00417612 Phase 3 Paricalcitol
7 Treatment of Autonomous Hyperparathyroidism in Post Renal Transplant Recipients Completed NCT00975000 Phase 3 Cinacalcet;Placebo
8 Emtricitabine/Tenofovir Disoproxil Fumarate for HIV Prevention in Men Completed NCT00458393 Phase 3 daily TDF/FTC;Placebo
9 BMS-Reyataz Study in Treatment in Naive Subjects to Compare the Efficacy and Safety Between Boosted Reyataz and Kaletra When in Combination With Fixed Dose Truvada Completed NCT00272779 Phase 3 ATV;RTV;Tenofovi-Emtricitabine (TDF/FTC) tablet;LPV
10 Therapeutic Use of Oral Sodium Phosphate (Z-521) in Primary Hypophosphatemic Rickets Completed NCT01237288 Phase 3 Z-521
11 Axitinib (AG 013736) As Second Line Therapy For Metastatic Renal Cell Cancer Completed NCT00678392 Phase 3 Axitinib (AG-013736);Sorafenib
12 A Clinical Trial Testing The Efficacy Of Crizotinib Versus Standard Chemotherapy Pemetrexed Plus Cisplatin Or Carboplatin In Patients With ALK Positive Non Squamous Cancer Of The Lung Completed NCT01154140 Phase 3 treatment;treatment
13 A Trial Comparing the Incidence of Hypophosphatemia in Relation to Treatment With Iron Isomaltoside and Ferric Carboxymaltose in Subjects With Iron Deficiency Anaemia (IDA-05) Recruiting NCT03237065 Phase 3 Iron Isomaltoside (Monofer);Ferric carboxymaltose
14 A Trial Comparing the Incidence of Hypophosphatemia in Relation to Treatment With Iron Isomaltoside and Ferric Carboxymaltose in Subjects With Iron Deficiency Anaemia (IDA-04) Recruiting NCT03238911 Phase 3 Iron isomaltoside (Monofer);Ferric carboxymaltose
15 Open Label Trial Assessing Safety and Efficacy of Burosumab (KRN23), in a Patient With ENS and Hypophosphatemic Rickets Recruiting NCT03581591 Phase 3
16 Lanthanum Carbonate (Fosrenol®) to Reduce Oxalate Excretion in Patients With Secondary Hyperoxaluria and Nephrolithiasis Recruiting NCT03346369 Phase 3 Lanthanum Carbonate
17 Open Label Study of KRN23 on Osteomalacia in Adults With X-linked Hypophosphatemia (XLH) Active, not recruiting NCT02537431 Phase 3
18 Study of KRN23 in Adults With X-linked Hypophosphatemia (XLH) Active, not recruiting NCT02526160 Phase 3
19 Efficacy and Safety of KRN23 Versus Oral Phosphate and Active Vitamin D Treatment in Pediatric Patients With X Linked Hypophosphatemia (XLH) Active, not recruiting NCT02915705 Phase 3 oral phosphate;active vitamin D
20 A Study of KRN23 in Pediatric Patients With X-linked Hypophosphatemic Rickets/Osteomalacia Active, not recruiting NCT03233126 Phase 3 KRN23
21 Investigating a New Way of Giving Medicine to Newborn and Preterm Babies Unknown status NCT01676844 Phase 2 Oral thin film therapy (Potassium acid phosphate oral thin films);Standard therapy (Potassium acid phosphate oral solution)
22 An Extension Study of KRN23 in Adults With X-Linked Hypophosphatemia Completed NCT01571596 Phase 1, Phase 2 KRN23
23 A Repeated Study of KRN23 in Adults With X-Linked Hypophosphatemia Completed NCT01340482 Phase 1, Phase 2 KRN23
24 Hypophosphatemia With Ferric Carboxymaltose Vs. Iron Dextran in Iron Deficiency Secondary to Heavy Uterine Bleeding Completed NCT01307007 Phase 2 Ferric Carboxymaltose (FCM);Iron Dextran Injection
25 Extended Safety Study of Tenofovir Disoproxil Fumarate (TDF) Among HIV-1 Negative Men Completed NCT00131677 Phase 2 tenofovir disoproxil fumarate;placebo
26 The Effects of Sevelamer Carbonate on Diabetic Nephropathy Completed NCT01493050 Phase 2 Sevelamer Carbonate;calcium carbonate
27 Veliparib and Temozolomide in Treating Patients With Recurrent Glioblastoma Completed NCT01026493 Phase 1, Phase 2 temozolomide 60 mg x 21 days;temozolomide 75 mg x 21 days;ABT-888 20 mg x 21 days;ABT-888 40 mg x 21 days;Temozolomide 150 mg x 5 days;ABT-888 40 mg x 5 days
28 Cixutumumab and Temsirolimus in Treating Patients With Locally Recurrent or Metastatic Breast Cancer Completed NCT00699491 Phase 1, Phase 2 Temsirolimus
29 Cetuximab and Lenalidomide in Head and Neck Completed NCT01133665 Phase 2 Cetuximab and Lenalidomide
30 Growth Hormone Treatment in Children With Hypophosphatemic Rickets Completed NCT02720770 Phase 1, Phase 2 norditropine simplex
31 Study of AVE0005 (VEGF Trap) in Locally Advanced or Metastatic Platinum- and Erlotinib- Resistant Non-small-cell-lung Adenocarcinoma Completed NCT00284141 Phase 2 Aflibercept (ziv-aflibercept, AVE0005, VEGF trap, ZALTRAP®)
32 Washington Study of Hemofiltration After Out-of-Hospital Cardiac Arrest Completed NCT01509040 Phase 1, Phase 2
33 Role Of Phosphorus And FGF 23 In Patients With Dent Disease Recruiting NCT02016235 Phase 1, Phase 2 Phosphorus Supplement
34 Study of KRN23, a Recombinant Fully Human Monoclonal Antibody Against Fibroblast Growth Factor 23 (FGF23), in Pediatric Subjects With X-linked Hypophosphatemia (XLH) Active, not recruiting NCT02163577 Phase 2
35 Study of the Safety, Pharmacodynamics (PD) and Efficacy of KRN23 in Children From 1 to 4 Years Old With X-linked Hypophosphatemia (XLH) Active, not recruiting NCT02750618 Phase 2
36 Long-Term Extension Study of KRN23 in Adult Subjects With X-Linked Hypophosphatemia (XLH) Active, not recruiting NCT02312687 Phase 2
37 Phase 1/2 Study of TP-0903 (an Inhibitor of AXL Kinase) in Patients With Previously Treated CLL Not yet recruiting NCT03572634 Phase 1, Phase 2 TP-0903
38 BGJ398 for the Treatment of Tumor-Induced Osteomalacia Not yet recruiting NCT03510455 Phase 2 BGJ398
39 Study of Ixazomib With Pegylated IFN-alpha 2b (pIFN) in Metastatic Renal Cell Carcinoma (mRCC) Terminated NCT02447887 Phase 1, Phase 2 Ixazomib;Pegylated IFN-alpha 2b
40 Study of CCNU (Lomustine) Plus Dasatinib in Recurrent Glioblastoma (GBM) Terminated NCT00948389 Phase 1, Phase 2 Dasatinib;Lomustine
41 A Study to Evaluate Pazopanib in Comparison to Pemetrexed in Maintenance Setting in Non-progressing Subjects With Metastatic Stage IVA and IVB Non-squamous Non-small Cell Lung Cancer (NSCLC) Population Terminated NCT01313663 Phase 2 pazopanib;pemetrexed
42 Effects of GH on Body Proportions and Final Height in X-Linked Hypophosphatemic Rickets Unknown status NCT00473187 Phase 1 somatropin
43 Effect of Cinacalcet on Parathyroid Hormone Secretion in Children and Adolescents With Hypophosphatemic Rickets Unknown status NCT00195936 Phase 1 Cinacalcet
44 A Study of KRN23 in X-linked Hypophosphatemia Completed NCT00830674 Phase 1 Placebo;KRN23
45 Multiple Dose Study to Evaluate the Safety of Multiple Doses of Denosumab 120 mg in Adults With Severe Chronic Kidney Disease (CKD) and CKD on Dialysis Completed NCT01464931 Phase 1 Denosumab
46 A Study Of Combined C- MET Inhibitor And PAN-HER Inhibitor (PF-02341066 And PF-00299804) In Patients With Non- Small Cell Lung Cancer Completed NCT01121575 Phase 1 PF-02341066;PF-00299804;PF-02341066;PF-00299804
47 A Study of KRN23 in Subjects With X-linked Hypophosphatemic Rickets/Osteomalacia Completed NCT02181764 Phase 1 KRN23
48 A First In Patient, Study Of Investigational Drug PF-03446962 In Patients With Advanced Solid Tumors Completed NCT00557856 Phase 1 PF-03446962
49 Simvastatin With Topotecan and Cyclophosphamide in Relapsed and/or Refractory Pediatric Solid and CNS Tumors Recruiting NCT02390843 Phase 1 Simvastatin;Cyclophosphamide;Topotecan;Myeloid growth factor
50 Mechanistic Evaluation on Sorafenib Induced Hypophosphatemia. Terminated NCT00622479 Phase 1 Sorafenib (Nexavar, BAY43-9006)

Search NIH Clinical Center for Hypophosphatemia

Inferred drug relations via UMLS 73 / NDF-RT 51 :
Sources

Genetic Tests for Hypophosphatemia

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Genetic tests related to Hypophosphatemia:

# Genetic test Affiliating Genes
1 Hypophosphatemia 29
Sources

Anatomical Context for Hypophosphatemia

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MalaCards organs/tissues related to Hypophosphatemia:

41
Kidney, Bone, Liver, Lung, Myeloid, Skeletal Muscle, Testes
Sources

Publications for Hypophosphatemia

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Articles related to Hypophosphatemia:

(show top 50) (show all 651)
# Title Authors Year
1
Outcome of adult patients with X-linked hypophosphatemia caused by PHEX gene mutations. ( 29460029 )
2018
2
High-Dose Ferric Carboxymaltose in Patients With HFrEF Induces Significant Hypophosphatemia. ( 29747838 )
2018
3
Hypophosphatemia occurs with insulin administration during refeeding by total parenteral nutrition in rats. ( 29593193 )
2018
4
X-linked hypophosphatemia and FGF23-related hypophosphatemic diseases -Prospect for new treatment. ( 29381780 )
2018
5
Reply: Hypophosphatemia, Severe Bone Pain, Gait Disturbance, and Fatigue Fractures After Iron Substitution in Inflammatory Bowel Disease: A Case Report. ( 29314243 )
2018
6
Burosumab Therapy in Children with X-Linked Hypophosphatemia. ( 29791829 )
2018
7
Clinical and genetic characteristics of 15 families with hereditary hypophosphatemia: Novel Mutations in PHEX and SLC34A3. ( 29505567 )
2018
8
Fibroblast Growth Factor 23-Induced Hypophosphatemia in Acute Leukemia. ( 29696242 )
2018
9
Hypophosphatemia in a Malnourished Child: When Renal Fanconi Syndrome Does Not Stand for Refeeding Syndrome. ( 29746006 )
2018
10
Prevention of hypophosphatemia during continuous renal replacement therapy-An overlooked problem. ( 29405468 )
2018
11
Hypophosphatemia as a sign of malnutrition in older hospitalized patients. ( 29967545 )
2018
12
Respiratory failure in a diabetic ketoacidosis patient with severe hypophosphatemia. ( 29969883 )
2018
13
Impaired mineral quality in dentin in X-linked hypophosphatemia. ( 29745817 )
2018
14
Hypercalcemia and hypophosphatemia among preterm infants receiving aggressive parenteral nutrition. ( 29756708 )
2018
15
Three-Month Randomized Clinical Trial of Nasal Calcitonin in Adults with X-linked Hypophosphatemia. ( 29383408 )
2018
16
Association Between Iron-Deficiency Anemia and Hypophosphatemia. ( 29031590 )
2018
17
Early hypophosphatemia in very low birth weight preterm infants. ( 29790700 )
2018
18
Hypophosphatemia as a Predictor of Organ-Specific Complications Following Gastrointestinal Surgery: Analysis of 8034 Patients. ( 29955938 )
2018
19
Hypophosphatemia and duration of respiratory failure and mortality in critically ill patients. ( 29687440 )
2018
20
A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial Evaluating the Efficacy of Burosumab, an Anti-FGF23 Antibody, in Adults With X-Linked Hypophosphatemia: Week 24 Primary Analysis. ( 29947083 )
2018
21
Hypophosphatemia ( 29630224 )
2018
22
Suitability of oral administration of monosodium phosphate, disodium phosphate, and magnesium phosphate for the rapid correction of hypophosphatemia in cattle. ( 29572937 )
2018
23
Impact of Conventional Medical Therapy on Bone Mineral Density and Bone Turnover in Adult Patients with X-Linked Hypophosphatemia: A 6-Year Prospective Cohort Study. ( 29143140 )
2017
24
Dental management of patients with X-linked hypophosphatemia. ( 28503481 )
2017
25
Correction to: X-linked hypophosphatemia and growth. ( 29110236 )
2017
26
Therapeutic Effects of FGF23 c-tail Fc in a Murine Preclinical Model of X-Linked Hypophosphatemia Via the Selective Modulation of Phosphate Reabsorption. ( 28600887 )
2017
27
Post-Transplant Hypophosphatemia and the Risk of Death-Censored Graft Failure and Mortality after Kidney Transplantation. ( 28546442 )
2017
28
Cardiovascular consequences of hypophosphatemia. ( 28497938 )
2017
29
Hypophosphatemia associated risk factors in pediatric intensive care patients. ( 29168361 )
2017
30
Craniofacial and dental characteristics of patients with vitamin-D-dependent rickets type 1A compared to controls and patients with X-linked hypophosphatemia. ( 28608052 )
2017
31
Comparison of calcimimetic R568 and calcitriol in mineral homeostasis in the Hyp mouse, a murine homolog of X-linked hypophosphatemia. ( 28728941 )
2017
32
Hypophosphatemia after nontraumatic intracranial hemorrhage. ( 28497591 )
2017
33
Corn-Soy-Blend Fortified with Phosphorus to Prevent Refeeding Hypophosphatemia in Undernourished Piglets. ( 28081252 )
2017
34
Severe Hypophosphatemia Following Denosumab Administration in a Hemodialysis Patient with Progressive Prostate Cancer. ( 28462158 )
2017
35
The influence of hypophosphatemia on outcomes of low- and high-intensity continuous renal replacement therapy in critically ill patients with acute kidney injury. ( 28904875 )
2017
36
Letter: inconsistency in reporting of hypophosphatemia after intravenous iron. ( 28805320 )
2017
37
Re: Hypophosphatemia, Severe Bone Pain, Gait Disturbance, and Fatigue Fractures After Iron Substitution in Inflammatory Bowel Disease: A Case Report. ( 29281128 )
2017
38
Specific ablation of mouse Fam20C in cells expressing type I collagen leads to skeletal defects and hypophosphatemia. ( 28620244 )
2017
39
Tumour genesis syndrome: severe hypophosphatemia and hypokalemia may be ominous presenting findings in childhood acute myeloid leukaemia. ( 28474100 )
2017
40
Hypophosphatemia in Users of Cannabis. ( 27692442 )
2017
41
Evidence for a role of PDZ domain-containing proteins to mediate hypophosphatemia in calcium stone formers. ( 29126251 )
2017
42
Euglycemic Diabetic Ketoacidosis Accompanied by Severe Hypophosphatemia During Recovery in a Patient With Type 2 Diabetes Being Treated With Canagliflozin/Metformin Combination Therapy. ( 29109617 )
2017
43
Hypophosphatemia after Hepatectomy or Pancreatectomy: Role of the Nicotinamide Phosphoribosyltransferase. ( 28690207 )
2017
44
X-linked hypophosphatemia with enthesopathy. ( 28784895 )
2017
45
Hypophosphatemia in critically ill patients with acute kidney injury treated with hemodialysis is associated with adverse events. ( 28616212 )
2017
46
Osteopontin and the dento-osseous pathobiology of X-linked hypophosphatemia. ( 27884786 )
2017
47
Hypophosphatemia predicts a failure to recover from adefovir-related renal injury after dose reduction in lamivudine-resistant hepatitis B patients. ( 28079295 )
2017
48
Hormonal Regulation of Osteocyte Perilacunar and Canalicular Remodeling in the Hyp Mouse Model of X-Linked Hypophosphatemia. ( 29083055 )
2017
49
[Identification of a novel splicing mutation of PHEX gene in a pedigree affected with X-linked hypophosphatemia]. ( 28397222 )
2017
50
Aggressive Treatment of Life-Threatening Hypophosphatemia During Recovery From Fulminant Hepatic Failure: A Case Report. ( 29088996 )
2017
Sources

Variations for Hypophosphatemia

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Expression for Hypophosphatemia

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Search GEO for disease gene expression data for Hypophosphatemia.
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Pathways for Hypophosphatemia

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Pathways related to Hypophosphatemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Parathyroid hormone synthesis, secretion and action 37
11.05 BGLAP FGF23 PTH SLC34A1 SLC34A3
2
FGF signaling pathway 1
10.99 BGLAP FGF23
3
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
10.91 BGLAP PTH
4
Development_Hedgehog and PTH signaling pathways in bone and cartilage development 22
10.75 BGLAP PTH
5
Osteoblast Signaling 1
10.28 BGLAP FGF23 PTH
Sources

GO Terms for Hypophosphatemia

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Cellular components related to Hypophosphatemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 BGLAP ENPP1 FAM20C FGF23 PTH SFRP4
2 vesicle GO:0031982 9.33 BGLAP SLC34A1 SLC34A3
3 endoplasmic reticulum lumen GO:0005788 9.26 BGLAP DMP1 FAM20C FGF23
4 extracellular region GO:0005576 9.23 BGLAP DMP1 DSPP ENPP1 FAM20C FGF23

Biological processes related to Hypophosphatemia according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.83 DMP1 FAM20C FGF23 SLC34A1
2 ossification GO:0001503 9.71 BGLAP DMP1 DSPP SLC34A1
3 skeletal system development GO:0001501 9.65 BGLAP DSPP FAM20C PHEX PTH
4 regulation of bone mineralization GO:0030500 9.63 BGLAP ENPP1 FGF23
5 ATP metabolic process GO:0046034 9.61 ENPP1 FAM20C
6 bone mineralization GO:0030282 9.61 BGLAP PHEX
7 response to vitamin D GO:0033280 9.61 BGLAP PHEX PTH
8 positive regulation of bone mineralization GO:0030501 9.6 FAM20C PTH
9 response to cadmium ion GO:0046686 9.59 PTH SLC34A1
10 phosphate-containing compound metabolic process GO:0006796 9.58 ENPP1 FGF23
11 response to lead ion GO:0010288 9.58 PTH SLC34A1
12 response to growth hormone GO:0060416 9.57 PHEX SLC34A1
13 response to magnesium ion GO:0032026 9.56 FGF23 SLC34A1
14 phosphate ion transport GO:0006817 9.55 SLC34A1 SLC34A3
15 sodium-dependent phosphate transport GO:0044341 9.54 SLC34A1 SLC34A3
16 cellular response to vitamin D GO:0071305 9.54 BGLAP FGF23 PHEX
17 response to parathyroid hormone GO:0071107 9.51 PTH SLC34A1
18 cellular response to parathyroid hormone stimulus GO:0071374 9.5 FGF23 PHEX SLC34A1
19 dentinogenesis GO:0097187 9.49 FAM20C SLC34A1
20 response to sodium phosphate GO:1904383 9.48 FGF23 PHEX
21 phosphate ion homeostasis GO:0055062 9.33 FGF23 SFRP4 SLC34A1
22 cellular phosphate ion homeostasis GO:0030643 9.26 ENPP1 FGF23 SLC34A1 SLC34A3
23 biomineral tissue development GO:0031214 9.1 BGLAP DMP1 DSPP ENPP1 FAM20C PHEX

Molecular functions related to Hypophosphatemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.55 BGLAP DMP1 DSPP ENPP1 FAM20C
2 sodium:phosphate symporter activity GO:0005436 8.96 SLC34A1 SLC34A3
3 sodium-dependent phosphate transmembrane transporter activity GO:0015321 8.62 SLC34A1 SLC34A3
Sources

Sources for Hypophosphatemia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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