Hypoplastic Left Heart Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HYP055 MIFTS: 62	Hypoplastic Left Heart Syndrome Categories: Rare diseases, Cardiovascular diseases, Fetal diseases, Genetic diseases
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Aliases & Classifications for Hypoplastic Left Heart Syndrome

MalaCards integrated aliases for Hypoplastic Left Heart Syndrome:

Name: Hypoplastic Left Heart Syndrome ³⁸ ¹² ⁷⁶ ⁵³ ⁵⁹ ³⁷ ²⁹ ⁶ ⁴⁴ ¹⁵ ⁷³

Hlhs ⁵³ ⁵⁹

Heart, Hypoplastic Left, Syndrome ⁴⁰

Characteristics:

Orphanet epidemiological data:

⁵⁹

hypoplastic left heart syndrome
Prevalence: 1-5/10000 (Europe),1-5/10000 (Austria),1-5/10000 (Belgium),1-5/10000 (Croatia),1-5/10000 (Denmark),1-5/10000 (France),1-5/10000 (Germany),1-5/10000 (Hungary),1-5/10000 (Ireland),1-9/100000 (Italy),1-5/10000 (Malta),1-9/100000 (Netherlands),1-5/10000 (Norway),1-9/100000 (Poland),1-9/100000 (Portugal),1-5/10000 (Switzerland),1-5/10000 (United Kingdom),1-5/10000 (Ukraine),1-9/100000 (Spain); Age of onset: Antenatal,Neonatal;

Classifications:

MalaCards categories:
Global: Rare diseases Fetal diseases Genetic diseases
Anatomical: Cardiovascular diseases

See all MalaCards categories (disease lists)

ICD10: ³³ ³⁴

Congenital malformations, deformations and chromosomal abnormalities

Congenital malformations of the circulatory system

Congenital malformations of aortic and mitral valves

Hypoplastic left heart syndrome

Orphanet: ⁵⁹

Rare cardiac malformations

Developmental anomalies during embryogenesis

External Ids:

Disease Ontology ¹² DOID:9955

ICD10 ³³ Q23.4

ICD9CM ³⁵ 746.7

MeSH ⁴⁴ D018636

NCIt ⁵⁰ C98894

SNOMED-CT ⁶⁸ 62067003

Orphanet ⁵⁹ ORPHA2248

MESH via Orphanet ⁴⁵ D018636

UMLS via Orphanet ⁷⁴ C0152101

ICD10 via Orphanet ³⁴ Q23.4

KEGG ³⁷ H01272

SNOMED-CT via HPO ⁶⁹ 253366007 405752007 70142008 more

UMLS ⁷³ C0152101

Sources

Summaries for Hypoplastic Left Heart Syndrome

NIH Rare Diseases : ⁵³ The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 2248Disease definitionHypoplastic left heart syndrome (HLHS) refers to the abnormal development of the left-sided cardiac structures, resulting in obstruction to blood flow from the left ventricular outflow tract. In addition, the syndrome includes underdevelopment of the left ventricle, aorta, and aortic arch, as well as mitral atresia or stenosis.EpidemiologyHLHS has been reported to occur in 1-2 in 6250 live births.Clinical descriptionNewborn infants with the condition are generally born at full term and initially appear healthy. As the arterial duct closes, systemic perfusion decreases, resulting in hypoxemia, acidosis, and cardiogenic shock. Usually, no heart murmur (or a non-specific heart murmur) is detected. The second heart sound is loud and single because of aortic atresia. Often the liver is enlarged secondary to congestive heart failure.EtiologyThe embryologic cause of the disease, as in the case of most congenital cardiac defects, is not fully known.Diagnostic methodsThe most useful diagnostic modality is the echocardiogram.Differential diagnosisDifferential diagnosis includes other left-sided obstructive lesions where the systemic circulation is dependent on ductal flow (critical aortic stenosis, coarctation of the aorta, interrupted aortic arch: see these terms).Antenatal diagnosisThe syndrome can be diagnosed by fetal echocardiography between 18 and 22 weeks of gestation.Management and treatmentChildren with the syndrome require neonatal surgery, as they have duct-dependent systemic circulation. Currently, there are two major modalities, primary cardiac transplantation or a series of staged functionally univentricular palliations. The treatment chosen is dependent on the preference of the institution and its experience.PrognosisAlthough survival following initial surgical intervention has improved significantly over the last 20 years, significant mortality and morbidity are associated with both surgical strategies. As a result, pediatric cardiologists continue to be challenged by discussions with families regarding the initial decision relative to the treatment and long-term prognosis, particularly as information on long-term survival and quality of life for those born with the syndrome is limited.Visit the Orphanet disease page for more resources.

MalaCards based summary : Hypoplastic Left Heart Syndrome, also known as hlhs, is related to hypoplastic left heart syndrome 1 and aortic valve disease 1. An important gene associated with Hypoplastic Left Heart Syndrome is TBX20 (T-Box 20), and among its related pathways/superpathways are Gap junction and Mesodermal Commitment Pathway. The drugs Bosentan and Citric Acid have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and endothelial, and related phenotypes are patent ductus arteriosus and mitral stenosis

Disease Ontology : ¹² A congenital heart disease characterized by abnormal development of the left-sided structures of the heart.

Wikipedia : ⁷⁶ Hypoplastic left heart syndrome (HLHS) is a rare congenital heart defect in which the left side of the... more...

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Related Diseases for Hypoplastic Left Heart Syndrome

Diseases in the Hypoplastic Left Heart Syndrome family:

Hypoplastic Left Heart Syndrome 1

Hypoplastic Left Heart Syndrome 2

Diseases related to Hypoplastic Left Heart Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)

#	Related Disease	Score	Top Affiliating Genes
1	hypoplastic left heart syndrome 1	35.1	FOXP1 GJA1 HAND1
2	aortic valve disease 1	30.8	NKX2-6 NOTCH1 NPPB TNNI3
3	atrial standstill 1	30.2	MYH6 NPPB TNNI3
4	kleefstra syndrome	30.0	EHMT1 NOTCH1
5	aortic valve disease 2	30.0	NKX2-6 NOTCH1 NPPA NPPB SMAD6 TNNI3
6	patent foramen ovale	29.7	MYH6 NKX2-5 TBX20
7	arteries, anomalies of	29.6	LEP NPPB TNNI3
8	tricuspid atresia	29.5	NKX2-5 NKX2-6
9	coronary artery anomaly	29.3	GJA1 NPPA NPPB TNNI3
10	ebstein anomaly	29.3	NKX2-5 NKX2-6 NPPB
11	atrial heart septal defect	28.7	MYH6 NKX2-5 NKX2-6 TBX20
12	double outlet right ventricle	28.5	HAND1 NKX2-5 NKX2-6 TBX20
13	heart disease	25.5	GATA5 GJA1 HAND1 MYH6 NKX2-5 NKX2-6
14	hypoplastic left heart syndrome 2	12.6
15	hemophagocytic lymphohistiocytosis	12.0
16	griscelli syndrome, type 2	11.3
17	ritscher-schinzel syndrome 1	11.0
18	cardiomyopathy, infantile histiocytoid	11.0
19	ventricular septal defect 3	11.0
20	hypoplastic right heart syndrome	11.0
21	heart, malformation of	10.6	MYH6 NOTCH1
22	lymphedema-distichiasis syndrome	10.6	FOXC2 FOXL1
23	distichiasis	10.5	FOXC2 FOXL1
24	hereditary lymphedema	10.5	FOXC2 FOXL1
25	cardiomyopathy, dilated, 1e	10.5	CDH2 GJA1 NKX2-5
26	familial bicuspid aortic valve	10.4	GATA5 NKX2-5 NOTCH1 SMAD6
27	deafness, autosomal recessive 79	10.4	EHMT1 NOTCH1
28	cerebritis	10.3
29	aging	10.2
30	aneurysm	10.2
31	transposition of the great arteries	10.2
32	right aortic arch	10.2
33	diaphragmatic hernia, congenital	10.1
34	endocardial fibroelastosis	10.1
35	enterocolitis	10.1
36	cor triatriatum	10.1
37	interatrial communication	10.1
38	myocarditis	10.1	MYH6 NPPB TNNI3
39	kabuki syndrome 1	10.0
40	perinatal necrotizing enterocolitis	10.0
41	atrial septal defect 4	10.0	MYH6 NKX2-5 TBX20
42	holt-oram syndrome	10.0
43	pagod syndrome	10.0
44	omphalocele	10.0
45	microcephaly	10.0
46	turner syndrome	10.0
47	pulmonary valve stenosis	10.0
48	aortic coarctation	10.0
49	cor triatriatum sinister	10.0
50	pentalogy of cantrell	10.0

Graphical network of the top 20 diseases related to Hypoplastic Left Heart Syndrome:

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Symptoms & Phenotypes for Hypoplastic Left Heart Syndrome

Human phenotypes related to Hypoplastic Left Heart Syndrome:

⁵⁹ ³² (show all 8)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	patent ductus arteriosus ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0001643
2	mitral stenosis ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0001718
3	maternal diabetes ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0009800
4	hypoplastic aortic arch ⁵⁹ ³²	frequent (33%)	Frequent (79-30%)	HP:0012304
5	atrial septal defect ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0001631
6	abnormality of chromosome segregation ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0002916
7	hypoplastic left heart ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0004383
8	mitral atresia ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0011560

MGI Mouse Phenotypes related to Hypoplastic Left Heart Syndrome:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.35	HAND1 FOXC2 TBX20 NKX2-6 LEP TNNI3
2	cellular	MP:0005384	10.23	NKX2-5 HAND1 TBX20 FOXL1 NKX2-6 LEP
3	homeostasis/metabolism	MP:0005376	10.2	SMAD6 HAND1 FOXC2 TBX20 NKX2-6 LEP
4	mortality/aging	MP:0010768	10.16	SMAD6 HAND1 FOXC2 TBX20 NKX2-6 FOXL1
5	growth/size/body region	MP:0005378	10.15	NKX2-5 FOXC2 HAND1 TBX20 FOXL1 NKX2-6
6	embryo	MP:0005380	10.1	HAND1 FOXC2 TBX20 NKX2-6 LEP NOTCH1
7	muscle	MP:0005369	10	TBX20 LEP TNNI3 GATA5 NOTCH1 CDH2
8	digestive/alimentary	MP:0005381	9.98	NKX2-5 FOXC2 HAND1 FOXL1 GATA5 LEP
9	normal	MP:0002873	9.56	NKX2-5 FOXC2 HAND1 TBX20 NKX2-6 NOTCH1
10	respiratory system	MP:0005388	9.28	NKX2-5 HAND1 FOXC2 NKX2-6 LEP NOTCH1

Sources

Drugs & Therapeutics for Hypoplastic Left Heart Syndrome

Drugs for Hypoplastic Left Heart Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Bosentan

Approved, Investigational

Phase 2

147536-97-8

104865

Synonyms:

147536-97-8

174227-18-0

4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide

4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulphornamide

4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide

4-t-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide

4-t-Butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide

4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide

4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide

-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide

AC-148

AC1L2XN2

Actelion

bosentan

Bosentan

bosentán

Bosentan (INN)

Bosentan [USAN:INN:BAN]

bosentan anhydrous

Bosentan anhydrous

Bosentan hydrate

Bosentan monohydrate

bosentanum

Bosentanum

C27H29N5O6S

CHEBI:51450

CHEMBL957

CID104865

D07538

DB00559

EN002863

HMS2090N14

I06-1873

KS-5062

L001086

LS-31532

MolPort-003-845-300

NCGC00167440-01

PDSP1_001731

PDSP2_001714

p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide

P-Tert-butyl-N-(6-(2-hydroxyethoxy)-5-(O-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide

P-Tert-butyl-N-(6-(2-hydroxyethoxy)-5-(O-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulphonamide

p-tert-Butyl-N-[6-(2-hydroxyethoxy)

Ro 47-0203

Ro 47-0203/039

Ro-47-0203

Ro-47-0203/029

Ro-47-0203/039

TL8001039

Tracleer

UNII-XUL93R30K2

Citric Acid

Approved, Nutraceutical, Vet_approved

Phase 2,Phase 1

77-92-9

311

Synonyms:

2-Hydroxy-1,2,3-propanetricarboxylate

2-Hydroxy-1,2,3-propanetricarboxylic acid

2-Hydroxytricarballylate

2-Hydroxytricarballylic acid

3-Carboxy-3-hydroxypentane-1,5-dioate

3-Carboxy-3-hydroxypentane-1,5-dioic acid

Acid monohydrate, citric

Aciletten

Anhydrous citrate

Anhydrous citric acid

beta-Hydroxytricarballylate

beta-Hydroxytricarballylic acid

Chemfill

Citraclean

Citrate

Citretten

Citric acid monohydrate

Citric acid, anhydrous

Citric Acid, Anhydrous

Citro

Citronensaeure

Citronensäure

e 330

e330

H3Cit

Hydrocerol a

Kyselina citronova

Monohydrate, citric acid

Suby g

Uralyt u

uro-Trainer

Phosphodiesterase 5 Inhibitors

Phase 2,Phase 1

Phosphodiesterase Inhibitors

Phase 2,Phase 1

Sildenafil Citrate

Phase 2,Phase 1

171599-83-0

Vasodilator Agents

Phase 2,Phase 1

Antihypertensive Agents

Phase 2

Endothelin Receptor Antagonists

Phase 2

Adrenergic Agents

Phase 2,Phase 1

Anesthetics

Phase 2

Neurotransmitter Agents

Phase 2,Phase 1

Epoetin alfa

Phase 1, Phase 2

113427-24-0

Hematinics

Phase 1, Phase 2

Citrate

Nutraceutical

Phase 2,Phase 1

Dexmedetomidine

Approved, Vet_approved

Phase 1

113775-47-6

68602 5311068

Synonyms:

(+)-4-((S)-a,2,3-Trimethylbenzyl)imidazole

(+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole

(+)-4-((S)-α,2,3-trimethylbenzyl)imidazole

(+)-medetomidine

(S)-medetomidine

113775-47-6

4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole

5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole

AC1NSJXT

C07450

CHEBI:4466

CHEMBL778

CID5311068

D00514

Dexmedetomidin

Dexmedetomidina

DEXMEDETOMIDINE

Dexmédétomidine

Dexmedetomidine (USAN/INN)

Dexmedetomidine hydrochloride

Dexmedetomidinum

Hospira brand OF dexmedetomidine hydrochloride

Hydrochloride, dexmedetomidine

Medetomidina [Spanish]

Medetomidine

Medetomidinum [Latin]

MPV 1440

MPV-1440

NCGC00025347-01

Precedex

PRECEDEX

Precedex (TN)

Tocris-2023

ZINC04632106

Adrenergic Agonists

Phase 1

Adrenergic alpha-2 Receptor Agonists

Phase 1

Adrenergic alpha-Agonists

Phase 1

Analgesics

Phase 1

Analgesics, Non-Narcotic

Phase 1

Central Nervous System Depressants

Phase 1

Hypnotics and Sedatives

Phase 1

Peripheral Nervous System Agents

Phase 1

Bupropion

Approved

34841-39-9, 34911-55-2

444

Synonyms:

( -)-2-(tert-Butylamino)-3'-chloropropiophenone

( -)-2-(tert-Butylamino)-3'-chlorpropiophenon

(+-)-1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone

(+-)-1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone

(+-)-Bupropion

.alpha.-(tert-Butylamino)-m-chloropropiophenone

1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]propan-1-one

2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one

2-(Tert-Butylamino)-3'-chloropropiophenone

34841-36-6 (hydrochloride)

34841-39-9

34911-55-2

AB00053756

AC-197

AC1L198Y

alpha-(tert-butylamino)-m-chloropropiophenone

Amfebutamon

Amfebutamona

Amfebutamona [INN-Spanish]

Amfebutamone

AMFEBUTAMONE HCl

amfebutamonum

Amfebutamonum

Amfebutamonum [INN-Latin]

BPBio1_000042

BRD-A05186015-003-05-7

BRN 2101062

BSPBio_000038

BSPBio_002247

bupropion

Bupropion (INN)

Bupropion (Old RN)

Bupropion (USAN)

Bupropion [INN:BAN]

Bupropion Hcl

Bupropion hydrochloride

Bupropion hydrochloride, (+-)-isomer

Bupropion hydrocloride

Bupropion SR

Bupropion, (+-)-isomer

C06860

CHEBI:3219

CHEMBL894

CID444

CPD000472526

D07591

DB01156

DivK1c_007050

Elont

Esteve brand OF bupropion hydrochloride

glaxo Wellcome brand 1 OF bupropion hydrochloride

glaxo Wellcome brand 2 OF bupropion hydrochloride

glaxo Wellcome brand 3 OF bupropion hydrochloride

GlaxoSmithKline brand 1 OF bupropion hydrochloride

GlaxoSmithKline brand 2 OF bupropion hydrochloride

HMS2051G10

HMS2089G14

Jsp006301

KBio1_001994

KBio2_002143

KBio2_004711

KBio2_007279

KBio3_001467

KBioGR_001168

KBioSS_002143

L000725

Lopac0_000166

LS-122817

MLS001424015

MolPort-003-845-432

NCGC00015122-06

NCGC00089751-02

NCI60_002714

NSC315851

Prestwick0_000249

Prestwick1_000249

Prestwick2_000249

Prestwick3_000249

Quomen

SAM001246699

SMR000472526

SPBio_001817

SPBio_002257

SpecPlus_000954

Spectrum_001663

Spectrum2_001659

Spectrum3_000644

Spectrum4_000614

Spectrum5_001406

TL8002604

UNII-01ZG3TPX31

Wellbatrin

Wellbutrin

Wellbutrin SR

Wellbutrin XL

Zyban

Zyban (anti-smoking)

Zyntabac

Dopamine

Approved

51-61-6, 62-31-7

681

Synonyms:

(3H)-Dopamine

.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane

.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride

1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)

1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride

1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium

153C5321-5FEE-4B0B-8925-F388F0EEEBD1

2-(3,4-dihydroxyphenyl)ethylamine

2-(3,4-Dihydroxyphenyl)ethylamine

2-benzenediol

3,4 Dihydroxyphenethylamine

3,4-dihydroxyphenethylamine

3,4-Dihydroxyphenethylamine

3,4-Dihydroxyphenethylamine hydrochloride

3,4-Dihydroxyphenylethylamine

3-Hydroxtyramine

3-Hydroxytyramine

3-Hydroxytyramine Hydrobromide

3-Hydroxytyramine hydrochloride

4-(2-Aminoethyl)-1,

4-(2-aminoethyl)-1,2-benzenediol

4-(2-Aminoethyl)-1,2-benzenediol

4-(2-Aminoethyl)-1,2-bezenediol

4-(2-Aminoethyl)benzene-1,2-diol

4-(2-aminoethyl)catechol

4-(2-Aminoethyl)catechol

4-(2-aminoethyl)pyrocatechol

4-(2-aminoethyl)-pyrocatechol

4-(2-Aminoethyl)pyrocatechol

4-(2-Aminoethyl)-pyrocatechol

4-(2-Aminoethyl)pyrocatechol hydrochloride

50444-17-2

51-61-6

62-31-7 (HYDROCHLORIDE)

a-(3,4-Dihydroxyphenyl)-b-aminoethane

AC1L19S5

AC1Q54AX

AC1Q54AY

AKOS003790978

alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane

ASL 279

BIDD:ER0506

Biomol-NT_000001

BPBio1_001123

BSPBio_001932

C03758

CHEBI:18243

CHEMBL59

CID681

cMAP_000036

cMAP_000065

D07870

DB00988

Deoxyepinephrine

DivK1c_000780

Dopamin

Dopamina

Dopamina [INN-Spanish]

dopamine

Dopamine

Dopamine (INN)

Dopamine (USAN)(*hydrochloride*)

Dopamine [INN:BAN]

Dopamine hydrochloride

Dopaminum

Dopaminum [INN-Latin]

Dopastat

Dophamine

Dynatra

EINECS 200-110-0

HSDB 3068

Hydrochloride, dopamine

Hydroxytyramin

hydroxytyramine

Hydroxytyramine

IDI1_000780

intropin

Intropin

Intropin [*hydrochloride*]

IP 498

KBio1_000780

KBio2_001492

KBio2_002388

KBio2_002484

KBio2_004060

KBio2_004956

KBio2_005052

KBio2_006628

KBio2_007524

KBio2_007620

KBio3_001152

KBio3_002867

KBio3_002962

KBioGR_001129

KBioGR_002388

KBioGR_002484

KBioSS_001492

KBioSS_002393

KBioSS_002491

KW-3-060

L000232

L-DOPAMINE

LDP

Lopac0_000586

Lopac-H-8502

LS-159

Medopa (TN)

m-Hydroxytyramine hydrochloride

MolPort-001-641-000

NCGC00015519-01

NCGC00015519-08

NCGC00096050-01

NCGC00096050-02

NCGC00096050-03

NCGC00096050-04

NCGC00096050-05

nchembio.105-comp9

nchembio.107-comp4

nchembio.284-comp1

nchembio.78-comp16

nchembio.89-comp3

nchembio705-8

nchembio801-comp8

NINDS_000780

NSC 173182

NSC169105

NSC173182

Oprea1_088821

Oxytyramine

Pyrocatechol, 4-(2-aminoethyl)- (8CI)

Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride

Revimine

Revivan

SPBio_001205

Spectrum_001012

SPECTRUM1505155

Spectrum2_001023

Spectrum3_000406

Spectrum4_000525

Spectrum5_000945

ST048774

STK301601

UNII-VTD58H1Z2X

UPCMLD0ENAT5885989:001

Ethanol

Approved

64-17-5

702

Synonyms:

(C6-C9)Alkyl alcohol

[CH2Me(OH)]

[OEtH]

02483_FLUKA

02851_FLUKA

02853_FLUKA

02854_FLUKA

02855_FLUKA

02856_FLUKA

02856_SIAL

02857_FLUKA

02857_SIAL

02858_FLUKA

02858_SIAL

02860_FLUKA

02865_FLUKA

02865_SIAL

02870_FLUKA

02870_SIAL

02875_FLUKA

02877_FLUKA

02878_FLUKA

02882_FLUKA

02882_SIAL

02883_FLUKA

02884_FLUKA

02890_FLUKA

02890_SIAL

02891_FLUKA

02891_SIAL

100C.NPA

121182-78-3

187380_ALDRICH

187380_SIAL

1-Hydroxyethane

24102_RIEDEL

24102_SIAL

24103_RIEDEL

24103_SIAL

24105_RIEDEL

24105_SIAL

24106_RIEDEL

24106_SIAL

24194_RIEDEL

24194_SIAL

245119_ALDRICH

245119_SIAL

270741_ALDRICH

270741_SIAL

277649_ALDRICH

277649_SIAL

2858_SIGMA

29221_FLUKA

32205_RIEDEL

32205_SIAL

32221_RIEDEL

32221_SIAL

32294_RIEDEL

32294_SIAL

34870_SIAL

34963_RIEDEL

39278_FLUKA

40210_ALDRICH

40210_RIEDEL

41322_FLUKA

458600_ALDRICH

458600_SIAL

459828_ALDRICH

459828_SIAL

459836_ALDRICH

459836_SIAL

459844_SIAL

48075_SUPELCO

493511_SIAL

493538_ALDRICH

493538_SIAL

493546_ALDRICH

493546_SIAL

64-17-5

676829_SIAL

68475-56-9

71076-86-3

71329-38-9

8000-16-6

8024-45-1

absolute alcohol

Absolute alcohol

Absolute Alcohol

Absolute ethanol

Absolute Ethanol

Absolute ethyl alcohol

AC1L19TW

AC1Q31MM

Aethanol

Aethanol [German]

Aethylalkohol

AHD 2000

AI3-01706

Alcare hand degermer

Alcare Hand Degermer

alcohol

Alcohol

Alcohol (ethyl)

Alcohol (USP)

Alcohol [USP]

ALCOHOL 5% IN D5-W

Alcohol anhydrous

Alcohol Anhydrous

Alcohol dehydrated

Alcohol denatured

alcohol etilico

Alcohol etilico

Alcohol etílico

Alcohol, absolute

Alcohol, Absolute

Alcohol, anhydrous

Alcohol, dehydrated

Alcohol, Dehydrated

Alcohol, denatured

Alcohol, diluted

Alcohol, Diluted

Alcohol, ethyl

Alcohol, grain

Alcohol, Grain

Alcohols

Alcohols, C1-3

Alcohols, C30

Alcohols, C6-9

Alcool ethylique

Alcool Ethylique

Alcool éthylique

Alcool etilico

Alcool Etilico

Algrain

Alkohol

Alkohol [German]

Alkoholu etylowego

Alkoholu Etylowego

Aminoethanol

Anhydrol

Anhydrol PM 4085

Anhydrous alcohol

Anhydrous ethanol

Äthanol

Äthylalkohol

Beta-Aminoethanol

Beta-Aminoethyl Alcohol

Beta-Ethanolamine

Beta-Hydroxyethylamine

bmse000297

C00469

C2H5OH

C2H6O

Caswell No. 426

Caswell No. 430

CCRIS 945

CDA 19

CDA 19-200

CHEBI:16236

CHEMBL545

CID702

Colamine

Cologne spirit

Cologne Spirit

Cologne spirits

D000431

D00068

DB00898

Dehydrated alcohol

Dehydrated ethanol

Dehydrated Ethanol

Denatured alcohol

Denatured Alcohol

Denatured Alcohol Cd-10

Denatured Alcohol Cd-5

Denatured Alcohol Cd-5a

Denatured Alcohol Sd-1

Denatured Alcohol Sd-13a

Denatured Alcohol Sd-17

Denatured Alcohol Sd-23a

Denatured Alcohol Sd-28

Denatured Alcohol Sd-30

Denatured Alcohol Sd-39b

Denatured Alcohol Sd-39c

Denatured Alcohol Sd-3a

Denatured Alcohol Sd-40m

Denatured ethanol

Denatured Ethanol

Desinfektol el

Desinfektol EL

Diluted alcohol

Distilled spirits

E2385_SIGMA

E7023_ALDRICH

E7023_SIAL

E7148_ALDRICH

E7148_SIAL

E7517_SIGMA

EINECS 200-578-6

EINECS 270-649-4

Envision Conditioner Pdd 9020

EOH

EOX

Esumiru WK 88

ETA

etanol

Etanol

Etanolo

Etanolo [Italian]

ethanol

éthanol

Ethanol (9CI)

Ethanol [JAN]

Ethanol 200 proof

Ethanol 200 Proof

Ethanol Absolute

Ethanol Absolute Bp

Ethanol Anhydrous

Ethanol Extra Pure

Ethanol solution

Ethanol Vapor

Ethanol, Silent Spirit

Ethanol, undenatured

Ethanolum anhydricum

Ethicap

Ethyl alc

ethyl alcohol

Ethyl alcohol

Ethyl Alcohol

Ethyl Alcohol & Water, 10%

Ethyl Alcohol & Water, 20%

Ethyl Alcohol & Water, 30%

Ethyl Alcohol & Water, 40%

Ethyl Alcohol & Water, 5%

Ethyl Alcohol & Water, 50%

Ethyl Alcohol & Water, 60%

Ethyl Alcohol & Water, 70%

Ethyl Alcohol & Water, 80%

Ethyl Alcohol & Water, 95%

Ethyl Alcohol & Water, 96%

Ethyl alcohol anhydrous

Ethyl Alcohol Anhydrous

Ethyl alcohol in alcoholic beverages

Ethyl alcohol usp

Ethyl Alcohol, Anhydrous

Ethyl Alcohol, Denatured

Ethyl hydrate

Ethyl Hydrate

Ethyl hydroxide

Ethyl Hydroxide

Ethylalcohol

Ethylalcohol [Dutch]

Ethylol

Ethylolamine

Ethyloxy Group

EtOH

Etylowy alkohol

FEMA No. 2419

FEMA Number 2419

Fermentation alcohol

Glycinol

grain alcohol

Grain alcohol

Hinetoless

HSDB 531

HSDB 82

Hydroxyethane

HYDROXYETHYL GROUP

I14-12648

IMS 99

Infinity pure

Infinity Pure

Jaysol

Jaysol S

LS-1539

LTBB002977

Lux

Methylated spirit

Methylated Spirit Mineralised

Methylcarbinol

Molasses alcohol

MolPort-001-785-844

NCGC00091458-01

nchem.651-comp3c

nchembio.552-comp10

nchembio.94-comp20

NCI-C03134

NSC 85228

NSC85228

Oxydimethylene Group

potato Alcohol

Potato alcohol

Punctilious ethyl alcohol

Pyro

QMHAIh@

Reagent Alcohol

Ru-Tuss Expectorant

SDA 3A

SDA 40-2

SDM No. 37

Sekundasprit

Silent spirit

Spirit

Spirits of wine

Spirits OF wine

spiritus vini

Spiritus vini

Spirt

SY Fresh M

Synasol

Tecsol

Tecsol C

Thanol

Thiofaco M-50

Undenatured ethanol

UNII-3K9958V90M

USAF EK-1597

WLN: Q2

Kava

Approved, Investigational, Nutraceutical

9000-38-8

Caffeine

Approved, Nutraceutical

58-08-2

2519

Synonyms:

07E4FB58-FD79-4175-8E3D-05BF96954522

1,3,7-trimethyl-2,6-dioxopurine

1,3,7-Trimethyl-2,6-dioxopurine

1,3,7-Trimethyl-3,7-dihydro-1H-purine-2,6-dione

1,3,7-trimethylpurine-2,6-dione

1,3,7-Trimethylpurine-2,6-dione

1,3,7-trimethylxanthine

1,3,7-Trimethylxanthine

1-3-7-TRIMETHYLXANTHINE

137X

1gfz

1l5q

1l7x

1-methyltheobromine

1-Methyltheobromine

1-Methyl-theobromine

27602_FLUKA

2a3b

3,7-dihydro-1,3,7-Trimethyl-1H-purin-2,6-dion

3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion

3,7-dihydro-1,3,7-trimethyl-1H-purine

3,7-dihydro-1,3,7-Trimethyl-1H-purine-2,6-dione

5-26-13-00558 (Beilstein)

58-08-2

71701-02-5

75035_FLUKA

7-Methyl theophylline

7-methyltheophylline

7-Methyltheophylline

95789-13-2

A.S.A. and Codeine Compound

AC-12774

AC1L1DV2

AC1Q3Z23

ACon1_000085

AI3-20154

AKOS000121334

Alert-pep

Alert-Pep

Anacin Maximum Strength

Anhydrous caffeine

Anhydrous caffeine (JP15)

Anhydrous caffeine (TN)

Anoquan

Berlin-chemie brand OF caffeine

Berlin-Chemie Brand of Caffeine

BIDD:ER0554

BIDD:GT0632

BIDD:PXR0172

BIM-0050216.0001

Bio-0579

Bio1_000473

Bio1_000962

Bio1_001451

bmse000206

BRD-K02404261-001-02-7

BRD-K02404261-001-03-5

Bristol-myers squibb brand OF caffeine

Bristol-Myers Squibb Brand of Caffeine

BRN 0017705

BSPBio_001921

C 0750

C07481

C0750_SIAL

C1778_SIAL

C2042

C6035_FLUKA

C6035_SIGMA

C7731_SIAL

C8960_SIAL

Cafamil

Cafcit

Cafecon

Cafeina

Cafeína

cafeine

Cafeine

Caféine

Cafergot

Caffedrine

Caffedrine Caplets

Caffein

Caffeina

Caffeina [Italian]

caffeine

Caffeine (natural)

Caffeine (USP)

Caffeine [BAN:JAN]

Caffeine Pure

Caffeine solution

Caffeine, anhydrous

Caffeine, Anhydrous

Caffeine, Monohydrate

Caffeine, synthetic

Caffeine, Synthetic

Caffeinum

caffenium

Caffine

Cafipel

CCRIS 1314

CFF

CHEBI:27732

CHEMBL113

CID2519

Coffein

Coffein [German]

Coffeine

Coffeinum

Coffeinum N

Coffeinum purrum

Coffeinum Purrum

component of Cafergot

Compound 65

CU-01000012617-3

D002110

D00528

Darvon Compound

Darvon Compound-65

Dasin

DB00201

Dexitac

Dexitac Stay Alert Stimulant

Dhc Plus

DHC Plus

DHCplus

Diurex

DivK1c_000730

Durvitan

EINECS 200-362-1

Eldiatric C

Enerjets

Ercatab

Esgic

Esgic-Plus

EU-0100228

FEMA No. 2224

Femcet

Fioricet

Fiorinal

GlaxoSmithKline brand OF caffeine

GlaxoSmithKline Brand of Caffeine

Guaranine

HMS1920I09

HMS2091O11

HMS502E12

HSDB 36

Hycomine

Hycomine Compound

I14-4386

IDI1_000730

Invagesic

Invagesic Forte

KBio1_000730

KBio2_001781

KBio2_004349

KBio2_006917

KBio3_001141

KBioGR_002325

KBioSS_001781

Keep Alert

Kofein

Kofein [Czech]

Koffein

Koffein [German]

L000155

Lanorinal

Lopac0_000228

Lopac-C-0750

LS-237

Mateina

Mateína

Maximum Strength Snapback Stimulant Powders

Medigesic Plus

MEGxp0_001350

Merck dura brand OF caffeine

Merck dura Brand of Caffeine

Methyltheobromide

Methyltheobromine

Methylxanthine theophylline

Midol Maximum Strength

Migergot

Miudol

MLS001055341

MLS001056714

MLS001066409

MolMap_000054

MolPort-000-730-850

Monohydrate caffeine

Monomethyl derivative of Theophylline

Monomethyl Derivative of Theophylline

Natural Caffeinum

NCGC00015208-01

NCGC00015208-02

NCGC00015208-04

NCGC00015208-14

NCGC00090699-01

NCGC00090699-02

NCGC00090699-03

NCGC00090699-04

NCGC00090699-05

NCGC00090699-06

NCGC00090699-07

NCGC00090699-08

NCGC00090699-09

NCGC00168808-01

NCGC00168808-02

nchembio.243-comp7

nchembio.63-comp5

nchembio774-comp2

NCI-C02733

NCIOpen2_008255

NINDS_000730

Nix Nap

no Doz

No Doz

Nodaca

No-Doz

Nodoz Maximum Strength Caplets

Norgesic

Norgesic Forte

NSC 5036

NSC5036

Organex

Orphengesic

Orphengesic Forte

P-A-C Analgesic Tablets

Passauer brand OF caffeine

Passauer Brand of Caffeine

PDSP1_001016

PDSP1_001235

PDSP2_001000

PDSP2_001219

Pep-Back

Percoffedrinol N

Percutafeine

Percutaféine

Phensal

Pierre fabre brand OF caffeine

Pierre Fabre Brand of Caffeine

Probes1_000150

Probes2_000128

Propoxyphene

Propoxyphene Compound 65

Propoxyphene Compound-65

Quick Pep

Quick-pep

Quick-Pep

Refresh'n

Republic drug brand OF caffeine

Republic Drug Brand of Caffeine

SDCCGMLS-0064595.P001

SDCCGMLS-0064595.P002

Seid brand OF caffeine

Seid Brand of Caffeine

SK 65 Compound

SK-65 Compound

SMR000326667

SPBio_001222

Spectrum_001301

SPECTRUM1500155

Spectrum2_001261

Spectrum3_000321

Spectrum4_001782

Spectrum5_000423

Stim

STK177283

Synalgos-Dc

teina

Teina

teína

Thein

Theine

Theobromine Me

Theobromine ME

Theophylline Me

Theophylline ME

Theophylline, 7-methyl

Thompson brand 1 OF caffeine

Thompson Brand 1 of Caffeine

Thompson brand 2 OF caffeine

Thompson Brand 2 of Caffeine

Tirend

TNP00310

Triad

Tri-Aqua

Ultra Pep-Back

UNII-3G6A5W338E

Vivarin

W222402_ALDRICH

Wake-Up

Wigraine

WLN: T56 BN DN FNVNVJ B1 F1 H1

Xanthine, 1,3,7-trimethyl

ZINC00001084

Vitamin C

Approved, Nutraceutical

Not Applicable

50-81-7

5785 54670067

Synonyms:

(+)-Ascorbate

(+)-Ascorbic acid

(+)-Sodium L-ascorbate

(2R)-2-[(1S)-1,2-dihydroxyethyl]-4,5-dihydroxyfuran-3-one

(2R)-2-[(1S)-1,2-Dihydroxyethyl]-4,5-dihydroxy-furan-3-one

(5R)-5-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one

129940-97-2

134-03-2 (monosodium salt)

14536-17-5

154170-90-8

2-(1,2-Dihydroxyethyl)-4,5-dihydroxyfuran-3-one

255564_SIAL

259133-78-3

30208-61-8

33034_RIEDEL

33034_SIAL

3-keto-L-Gulofuranolactone

3-Keto-L-gulofuranolactone

3-oxo-L-Gulofuranolactone

3-Oxo-L-gulofuranolactone

3-Oxo-L-gulofuranolactone (enol form)

47863_SUPELCO

47A605F0-4187-47A8-B0CE-F9E7DA1B0076

50-81-7

50976-75-5

56172-55-5

56533-05-2

57304-74-2

57606-40-3

623158-95-2

6730-29-6

882690-91-7

884381-69-5

885512-24-3

88845-26-5

89924-69-6

95209_FLUKA

95209_SIGMA

95210_FLUKA

95210_SIAL

95212_FLUKA

A0278_SIGMA

A0537

A2174_SIGMA

A2218_SIGMA

A2343_SIGMA

A4403_SIGMA

A4544_SIGMA

A5960_SIGMA

A7506_SIGMA

A92902_ALDRICH

A92902_SIAL

AB00376923

AB1002440

AC1L1L4T

AC1Q77S6

Acid Ascorbic

Acid, ascorbic

Acid, L-ascorbic

acide ascorbique

Acide ascorbique

Acide ascorbique [INN-French]

acido Ascorbico

Acido ascorbico

ácido ascórbico

Acido ascorbico [INN-Spanish]

acidum ascorbicum

Acidum ascorbicum

Acidum ascorbicum [INN-Latin]

acidum ascorbinicum

Acidum ascorbinicum

Adenex

Allercorb

Ambap36431-82-0

antiscorbic vita min

Antiscorbic vitamin

Antiscorbutic factor

Antiscorbutic vitamin

AR-1J3435

arco-Cee

Arco-cee

Ascoltin

Ascoltin (TN)

Ascorb

ascor-b.i.d

Ascor-b.i.d.

Ascor-B.I.D.

Ascorbajen

ascorbate

Ascorbate

Ascorbate, ferrous

Ascorbate, magnesium

Ascorbate, sodium

ascorbic acid

Ascorbic Acid

Ascorbic acid (JP15/USP/INN)

Ascorbic acid [BAN:INN:JAN]

Ascorbic acid [INN:BAN:JAN]

Ascorbic acid, monosodium salt

Ascorbic Acid, Monosodium Salt

Ascorbicab

Ascorbicap

Ascorbicap (TN)

Ascorbicin

Ascorbin

Ascorbinsaeure

Ascorbinsäure

Ascorbutina

Ascorbyl radical

Ascorin

Ascorteal

Ascorvit

bmse000182

BPBio1_000363

BSPBio_000329

C00072

C6H8O6

Cantan

Cantaxin

Caswell No. 061B

Catavin C

CCRIS 57

Ce lent

Cebicure

Cebid

Cebion

Cebione

Cecon

cee-caps td

Cee-caps TD

Cee-Caps TD

Cee-vite

Cee-Vite

Cegiolan

Ceglion

Ceklin

Celaskon

Celin

Cell C

Cemagyl

Ce-mi-lin

Ce-Mi-Lin

Cemill

Cenetone

Cenolate

Cereon

Cergona

Cescorbat

Cetamid

Cetane

Cetane-caps TC

Cetane-Caps TC

Cetane-caps TD

Cetane-Caps TD

Cetebe

Cetemican

Cevalin

Cevatine

Cevex

cevibid

Cevi-bid

Cevi-Bid

Cevimin

Ce-vi-sol

CE-VI-Sol

Cevital

Cevitamate

Cevitamic acid

Cevitamin

Cevitan

Cevitex

Cewin

CHEBI:29073

CHEMBL196

Chewcee

Ciamin

CID5785

Cipca

Citriscorb

Citrovit

C-Level

C-Long

Colascor

component of Cortalex

component of E and C-Level

component of Endoglobin Forte

component of Ferancee

Concemin

Cortalex

C-Quin

C-Span

C-Vimin

D00018

Davitamon C

DB00126

Di-L-ascorbate, magnesium

Dora-C-500

Duoscorb

e 300

e300

e-300

EINECS 200-066-2

FEMA No. 2109

Ferancee

Ferrous ascorbate

gamma-Lactone L-threo-hex-2-enonate

gamma-Lactone L-threo-hex-2-enonic acid

Hicee

HiCee

HSDB 818

Hybrin

ido-C

IDO-C

Iron(II) ascorbate

Iron-ascorbic acid complexes

Juvamine

Kangbingfeng

Kyselina askorbova

Kyselina askorbova [Czech]

L Ascorbic acid

L(+)-Ascorbate

L-(+)-Ascorbate

L-(+)-ascorbic acid

L(+)-Ascorbic acid

L-(+)-Ascorbic acid

L-(+)-Ascorbic Acid

L-3-ketothreohexuronic acid

L-3-Ketothreohexuronic acid lactone

Laroscorbine

L-ascorbate

L-Ascorbate

l-ascorbic acid

L-Ascorbic acid

L-Ascorbic Acid

L-Ascorbic acid, free radical form

Lemascorb

Liqui-cee

Liqui-Cee

L-Lyxoascorbate

L-Lyxoascorbic acid

LS-145

L-threo-ascorbic acid

L-threo-Ascorbic acid

L-Threoascorbic acid

l-threo-hex-1-eofuranos-3-ulose

L-threo-Hex-2-enonic acid, gamma-lactone

L-threo-hex-2-enono-1,4-lactone

L-Xyloascorbate

L-Xyloascorbic acid

Magnesium ascorbate

Magnesium ascorbicum

Magnesium Ascorbicum

Magnesium di L ascorbate

Magnesium di-L-ascorbate

Magnorbin

Meri-c

Meri-C

MLS002153776

MolPort-001-792-501

Monodehydroascorbic acid

Natrascorb

Natrascorb injectable

NCGC00091517-01

NCGC00091517-02

NCGC00164357-01

nchembio.174-comp5

nchembio.89-comp1

nchembio.92-comp2

nchembio821-comp9

NCI-C54808

NSC 33832

Oral Vitamin C

Planavit C

Prestwick3_000325

Proscorbin

Redoxon

Ribena

Ronotec 100

Rontex 100

roscorbi c

Roscorbic

Rovimix C

Scorbacid

Scorbu C

Scorbu-C

Secorbate

Semidehydroascorbate

SMR001233160

Sodascorbate

Sodium ascorbate

Sodium Ascorbate (Ascorbic Acid)

Stuartinic

Suncoat VC 40

Sunkist

Testascorbic

Tolfrinic

UNII-PQ6CK8PD0R

VASC

Vicelat

Vicin

Vicomin C

Viforcit

Viscorin

Viscorin 100m

Vitace

Vitacee

Vitacimin

Vitacin

vitamin C

Vitamin C

Vitamin- C

Vitamin-?C

Vitamisin

Vitascorbol

W210901_ALDRICH

Xitix

Antibodies

Immunoglobulins

Antidepressive Agents

Antidepressive Agents, Second-Generation

Antidepressive Agents, Tricyclic

Cytochrome P-450 CYP2D6 Inhibitors

Cytochrome P-450 Enzyme Inhibitors

Dopamine Agents

Dopamine Uptake Inhibitors

Neurotransmitter Uptake Inhibitors

Psychotropic Drugs

Vitamins

,Not Applicable

Antioxidants

Not Applicable

Micronutrients

Not Applicable

Protective Agents

Not Applicable

Trace Elements

Not Applicable

Calamus

Nutraceutical

Not Applicable

Interventional clinical trials:

(show top 50) (show all 60)

#	Name	Status	NCT ID	Phase	Drugs
1	Prophylactic Peritoneal Dialysis Decreases Time to Achieve a Negative Fluid Balance After the Norwood Procedure	Completed	NCT01215240	Phase 3
2	Study of Triostat in Infants During Heart Surgery	Completed	NCT00027417	Phase 3	Liothyronine sodium/triiodothyronine
3	Cardiac Stem/Progenitor Cell Infusion in Univentricular Physiology (APOLLON Trial)	Recruiting	NCT02781922	Phase 3
4	Sildenafil After the Fontan Operation	Completed	NCT00507819	Phase 2	Sildenafil;Placebo
5	Cardiac Progenitor Cell Infusion to Treat Univentricular Heart Disease (PERSEUS)	Completed	NCT01829750	Phase 2
6	Study of Placebo or Bosentan to Treat Patients With Single Ventricle Physiology.	Completed	NCT01292551	Phase 2	Bosentan;Placebo
7	Longeveron Mesenchymal Stem Cells (LMSCs) Delivered During Stage II Surgery for Hypoplastic Left Heart Syndrome (ELPIS)	Recruiting	NCT03525418	Phase 1, Phase 2
8	Mesoblast Stem Cell Therapy for Patients With Single Ventricle and Borderline Left Ventricle	Recruiting	NCT03079401	Phase 1, Phase 2
9	Maternal Hyperoxygenation in Congenital Heart Disease	Recruiting	NCT03136835	Phase 1, Phase 2	Maternal Hyperoxygenation
10	Ambrisentan in Single Ventricle	Active, not recruiting	NCT02080637	Phase 2	Ambrisentan
11	Erythropoetin Neuroprotection for Neonatal Cardiac Surgery	Active, not recruiting	NCT00513240	Phase 1, Phase 2	Erythropoetin;Normal saline
12	Autologous Umbilical Cord Blood Treatment of Neonate With CHD	Not yet recruiting	NCT03558269	Phase 1, Phase 2
13	Parenteral Phenoxybenzamine During Congenital Heart Disease Surgery	Withdrawn	NCT00770705	Phase 2	Phenoxybenzamine
14	Transcoronary Infusion of Cardiac Progenitor Cells in Patients With Single Ventricle Physiology	Completed	NCT01273857	Phase 1
15	Understanding Dexmedetomidine in Neonates After Open Heart Surgery	Completed	NCT00576381	Phase 1	Dexmedetomidine
16	Understanding Dexmedetomidine In Infants Post-Operative From Cardiac Surgery	Completed	NCT00573066	Phase 1	Dexmedetomidine
17	Sildenafil in Single Ventricle Patients	Completed	NCT01169519	Phase 1	Sildenafil by injection;Sildenafil by injection;Sildenafil by injection;Sildenafil by injection
18	Allogeneic hMSC Injection in Patients With Hypoplastic Left Heart Syndrome	Recruiting	NCT02398604	Phase 1	Allo-hMSCs;Placebo
19	Safety Study of Autologous Umbilical Cord Blood Cells for Treatment of Hypoplastic Left Heart Syndrome	Recruiting	NCT01883076	Phase 1
20	Safety of Autologous Cord Blood Cells in HLHS Patients During Norwood Heart Surgery	Recruiting	NCT03431480	Phase 1
21	Autologous Cardiac Stem Cell Injection in Patients With Hypoplastic Left Heart Syndrome: An Open Label Pilot Study.	Not yet recruiting	NCT03406884	Phase 1	c-kit+ cells;Placebo
22	Safety and Feasibility Study of Umbilical Cord Blood Cells for Infants With Hypoplastic Left Heart Syndrome	Suspended	NCT01445041	Phase 1
23	A Prospective Study of Patients With Hypoplastic Left Heart Syndrome (HLHS) Following Stage II Surgical Palliation	Unknown status	NCT01708863
24	Near-infrared Spectroscopy (NIRS) Neurodevelopmental Outcomes	Unknown status	NCT00464100
25	Global and Regional Myocardial Strain and Power Output In Patients With Single Ventricles Using Novel MRI Techniques	Unknown status	NCT01107990
26	Comparison of Feeding Strategies for Hypoplastic Left Heart Syndrome Infants	Completed	NCT02657629	Not Applicable
27	Neurodevelopmental Outcomes in Hypoplastic Left Heart Syndrome	Completed	NCT00399555
28	Evaluation of Panel Reactive Antibody in Children Following Stage I Palliation for Hypoplastic Left Heart Syndrome	Completed	NCT01135485
29	Single Ventricle Outcome	Completed	NCT00308217
30	Fluid Balance in Children Undergoing Fontan Surgery	Completed	NCT02306057
31	Bupropion & Cardio Birth Defect (Slone)	Completed	NCT01597661		Exposure to any bupropion during the first trimester;Exposure to bupropion alone during the first trimester
32	NIRS in Neonatal Cardiac Surgery	Completed	NCT00166101
33	Biomarker Study for Heart Failure in Children With Single Ventricle Physiology	Completed	NCT00571233
34	Impact of Vitamin C on Endothelial Function and Exercise Capacity in Fontan-Palliated Patients	Completed	NCT00974025	Not Applicable
35	Cerebral Perfusion During Neonatal Cardiac Surgery	Completed	NCT01032876	Not Applicable
36	Impact of Early Intervention on Maternal Stress in Mothers of Fetuses Diagnosed With Single Ventricle Physiology	Completed	NCT02462434	Not Applicable
37	Quality of Life Among Children With Congenital Heart Disease	Completed	NCT01202916
38	Association Between a Mother's Exposure to "Strep Throat" and Her Baby's Developing Heart Disease	Completed	NCT01603732
39	Prenatal Effects of Congenital Heart Disease (CHD) on Neurodevelopmental Outcome	Completed	NCT00713635
40	Cerebral Blood Flow in Single Ventricles Throughout Staged Surgical Reconstruction	Completed	NCT02135081
41	Umbilical Cord Blood Collection and Processing for Cardiac Regeneration in Hypoplastic Left Heart Syndrome Patients	Recruiting	NCT01856049	Not Applicable
42	Fetal Intervention for Aortic Stenosis and Evolving Hypoplastic Left Heart Syndrome	Recruiting	NCT01736956	Not Applicable
43	Cerebral Anatomy, Hemodynamics and Metabolism	Recruiting	NCT02919956
44	National Collaborative to Improve Care of Children With Complex Congenital Heart Disease	Recruiting	NCT02852031
45	Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study)	Recruiting	NCT02184169	Not Applicable
46	Genetic Determinants of Congenital Heart Disease Outcomes	Recruiting	NCT01656941
47	Splanchnic and Renal Tissue Oxygenation During Enteral Feedings in Neonates With Patent Ductus Arteriosus	Recruiting	NCT03551600
48	A Pilot Study- Monitoring Cerebral Blood Flow in Neonates With Congenital Heart Defects	Recruiting	NCT03512613
49	Family Adaptation Study Following the Diagnosis of Hypoplastic Left Heart Syndrome in a Newborn	Active, not recruiting	NCT00734643
50	SVRII Family Factors Study	Active, not recruiting	NCT01582529

Search NIH Clinical Center for Hypoplastic Left Heart Syndrome

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :

alprostadil

Cell-based therapeutics:

Data from LifeMap, the Embryonic Development and Stem Cells Database

Read about Hypoplastic Left Heart Syndrome cell therapies at LifeMap Discovery.

Stem-cell-based therapeutic approaches for Hypoplastic Left Heart Syndrome:

Cardiac progenitor cells for single-ventricle anomalies

Embryonic/Adult Cultured Cells Related to Hypoplastic Left Heart Syndrome:

	Cardiac progenitor cells PMIDs: 18754813 17502484 14530411
	Cardiac stem cells PMIDs: 18754813 17502484 14530411

Cochrane evidence based reviews: hypoplastic left heart syndrome

Sources

Genetic Tests for Hypoplastic Left Heart Syndrome

Genetic tests related to Hypoplastic Left Heart Syndrome:

#	Genetic test	Affiliating Genes
1	Hypoplastic Left Heart Syndrome ²⁹

Sources

Anatomical Context for Hypoplastic Left Heart Syndrome

MalaCards organs/tissues related to Hypoplastic Left Heart Syndrome:

⁴¹

Heart, Liver, Endothelial, Brain, Lung, Neutrophil, Kidney

Sources

Publications for Hypoplastic Left Heart Syndrome

Articles related to Hypoplastic Left Heart Syndrome:

(show top 50) (show all 750)

#	Title	Authors	Year
1	Improved Outcomes in Management of Hypoplastic Left Heart Syndrome Associated with Congenital Diaphragmatic Hernia: an Algorithmic Approach. ( 29448010 )	Balduf K....Knott-Craig C.J.	2018
2	Surgery for hypoplastic left heart syndrome. Taking the long view. ( 29248162 )	Shore D.	2018
3	Long term survival of hypoplastic left heart syndrome infants: Meta-analysis comparing outcomes from the modified Blalock-Taussig shunt and the right ventricle to pulmonary artery shunt. ( 29407078 )	Cao J.Y....Winlaw D.S.	2018
4	The grief and coping of parents whose child has a constant life-threatening disability, hypoplastic left heart syndrome with reference to the dual process model. ( 29338622 )	Cantwell-Bartl A.	2018
5	Right Ventricular Systolic Function Parameters in Hypoplastic Left Heart Syndrome. ( 29777281 )	Zaidi S.J....Roberson D.A.	2018
6	Longitudinal Deformation of the Right Ventricle in Hypoplastic Left Heart Syndrome: A Comparative Study of 2D-Feature Tracking Magnetic Resonance Imaging and 2D-Speckle Tracking Echocardiography. ( 29748699 )	Salehi Ravesh M....Logoteta J.	2018
7	Cerebral abscess in a young adult with hypoplastic left heart syndrome. ( 29803061 )	Greeneway G.P....Hsu W.	2018
8	Mortality in Children With Hypoplastic Left Heart Syndrome Undergoing Tracheostomy. ( 29685241 )	Mastropietro C.W.	2018
9	Hypoplastic left heart syndrome management. ( 29631801 )	Gaeta R....Fama' F.	2018
10	Prolonged PR Interval at Birth Predicting the High Occurrence of Fatal Atrioventricular Block in Hypoplastic Left Heart Syndrome. ( 29350247 )	Morihana E....Ohga S.	2018
11	The Genetic Landscape of Hypoplastic Left Heart Syndrome. ( 29569026 )	Yagi H....Lo C.W.	2018
12	Surgical Palliation for Hypoplastic Left Heart Syndrome: For Now, Just Keep Doing What You Do Best. ( 29784679 )	Fraser C.D.	2018
13	Necrotizing Enterocolitis in Infants with Hypoplastic Left Heart Syndrome Following Stage 1 Palliation or Heart Transplant. ( 29392349 )	ElHassan N.O....Prodhan P.	2018
14	Longitudinal Health Care Cost in Hypoplastic Left Heart Syndrome Palliation. ( 29774394 )	Hansen J.E....Anderson J.B.	2018
15	Early results of aortic arch reconstruction and bilateral pulmonary arteries banding: modification of the Norwood operation for treatment of hypoplastic left heart syndrome. ( 29350395 )	PajA8k J.W....Tomkiewicz-PajA8k L.	2018
16	Giessen Procedure as Comprehensive Stage II Palliation With Aortic Arch Reconstruction After Hybrid Bilateral Pulmonary Artery Banding and Ductal Stenting for Hypoplastic Left Heart Syndrome. ( 29425520 )	YAPrA1ker U....AkintA1rk H.	2018
17	Hypoplastic Left Heart Syndrome With a Hypoplastic Lung in Congenital Diaphragmatic Hernia: What Should Be Done First? ( 29702180 )	Huang S.C....Hsu W.M.	2018
18	Gastrostomy tube placement among infants with hypoplastic left heart syndrome undergoing stage 1 palliation. ( 29756326 )	Prodhan P....ElHassan N.O.	2018
19	Prognostic value of troponin in infants with hypoplastic left heart syndrome between Stage I and II of palliation. ( 29440831 )	Christmann M....Cavigelli-Brunner A.	2018
20	Interventional treatments and risk factors in patients born with hypoplastic left heart syndrome in England and Wales from 2000 to 2015. ( 29371373 )	Rogers L....Brown K.L.	2018
21	Hybrid strategies for high-risk non-hypoplastic left heart syndrome patients. ( 29896780 )	Rehman S.M....Viola N.	2018
22	Three-dimensional echocardiographic evaluation of Ebstein's anomaly of the tricuspid valve in a patient with hypoplastic left heart syndrome. ( 29679990 )	Cassidy C....Jone P.N.	2018
23	Outcomes and risk factors associated with tricuspid valve repair in children with hypoplastic left heart syndrome. ( 29788322 )	Alsoufi B....Kanter K.	2018
24	Stem Cell Therapy for Hypoplastic Left Heart Syndrome: Mechanism, Clinical Application, and Future Directions. ( 29976693 )	Bittle G.J....Kaushal S.	2018
25	Early Outcomes of Hypoplastic Left Heart Syndrome Infants: Meta-Analysis of Studies Comparing the Hybrid and Norwood Procedures. ( 29544421 )	Cao J.Y....Winlaw D.S.	2018
26	Congenital diaphragmatic hernia with heart defect has a high risk for hypoplastic left heart syndrome and major extra-cardiac malformations: 10-year national cohort from Finland. ( 29215158 )	Hautala J....Ojala T.	2018
27	Successful use of a ventricular assist device in a neonate with hypoplastic left heart syndrome with right ventricular dysfunction. ( 29970231 )	Maeda K....Almond C.S.	2018
28	Reduced Right Ventricular Fractional Area Change, Strain, and Strain Rate before Bidirectional Cavopulmonary Anastomosis is Associated with Medium-Term Mortality for Children with Hypoplastic Left Heart Syndrome. ( 29655509 )	Lin L.Q....Khoo N.S.	2018
29	Regional Differences in Cost and Length of Stay in Neonates with Hypoplastic Left Heart Syndrome. ( 29754202 )	Essaid L....Nelson J.S.	2018
30	Novel aortic arch reconstruction using a modified Norwood procedure based on hypoplastic left heart syndrome-specific anatomical malformations. ( 29546398 )	Konuma T....Shimpo H.	2018
31	The risk of overzealous application of hybrid strategies for patients with biventricular cardiac anomalies: Invited commentary regarding: &quot;Hybrid Strategies for High-Risk Non-Hypoplastic Left Heart Syndrome Patients&quot;. ( 29900667 )	Jonas R.A.	2018
32	A potentially curative fetal intervention for hypoplastic left heart syndrome. ( 29317056 )	Hattam A.T.	2018
33	Modified Hybrid Procedure in Hypoplastic Left Heart Syndrome: Initial Experience of a Center in Northeastern Brazil. ( 28832800 )	Faria R.M....Cascudo M.M.	2017
34	Hypoplastic Left Heart Syndrome Is Not a Predictor of Worse Intermediate Mortality Post Fontan. ( 29096870 )	Martin B.J....Ross D.B.	2017
35	NOTCH1-Dependent Nitric Oxide Signaling Deficiency in Hypoplastic Left Heart Syndrome Revealed Through Patient-Specific Phenotypes Detected in Bioengineered Cardiogenesis. ( 28142228 )	Hrstka S.C....Nelson T.J.	2017
36	Recoarctation After Norwood I Procedure for Hypoplastic Left Heart Syndrome: Impact of Patch Material. ( 28024650 )	Vitanova K....Lange R.	2017
37	Effect of acid-base balance on postoperative course in children with hypoplastic left heart syndrome after the modified Norwood procedure. ( 28834879 )	GA8adki M....Skalski J.H.	2017
38	Tricuspid Valve Hemangioma Associated with Hypoplastic Left Heart Syndrome Presenting as Sudden Infant Death Syndrome. ( 28272668 )	Gupta B....Kumar T.	2017
39	Hypoplastic Left Heart Syndrome Sequencing Reveals a Novel NOTCH1 Mutation in a Family with Single Ventricle Defects. ( 28608148 )	Durbin M.D....Hong C.C.	2017
40	Chromosomal Abnormalities Affect the Surgical Outcome in Infants with Hypoplastic Left Heart Syndrome: A Large Cohort Analysis. ( 28921168 )	Zakaria D....Prodhan P.	2017
41	Molecular cytogenetic characterization of Jacobsen syndrome (11q23.3-q25 deletion) in a fetus associated with double outlet right ventricle, hypoplastic left heart syndrome and ductus venosus agenesis on prenatal ultrasound. ( 28254208 )	Chen C.P....Wang W.	2017
42	Hypoplastic left heart syndrome and the allure of a valved conduit. ( 29370913 )	Burkhart H.M....Thompson J.L.	2017
43	Right ventricular systolic function in hypoplastic left heart syndrome: A comparison of manual and automated software to measure fractional area change. ( 28191731 )	Ruotsalainen H.K....Simpson J.M.	2017
44	Management of Tricuspid Regurgitation in Patients With Hypoplastic Left Heart Syndrome. ( 28684000 )	Pigula F.A....Mettler B.	2017
45	Relationship Between Cavum Septi Pellucidi Measurements and Fetal Hypoplastic Left Heart Syndrome or Dextro-Transposition of the Great Arteries. ( 29280178 )	Saadeh M....Abuhamad A.	2017
46	Hypoplastic Left Heart Syndrome with Congenital Complete Heart Block. ( 28512719 )	Al-Kubaisi M....Awad S.	2017
47	Acute kidney injury following first-stage palliation in hypoplastic left heart syndrome: hybrid versus Norwood palliation. ( 28889833 )	Garcia R.U....Aggarwal S.	2017
48	Effectiveness of interstage home monitoring on healthcare outcomes in infants with hypoplastic left heart syndrome: a systematic review protocol. ( 29035962 )	Andries C....Palokas M.	2017
49	Re-evaluation of hypoplastic left heart syndrome from a developmental and morphological perspective. ( 28793912 )	Crucean A....Chaudhry B.	2017
50	Hypoplastic Left Heart Syndrome with Intact or Restrictive Atrial Septum: A Report from the International Fetal Cardiac Intervention Registry. ( 28864444 )	Jantzen D.W....Gelehrter S.K.	2017

Sources

Genes for Hypoplastic Left Heart Syndrome

Genes related to Hypoplastic Left Heart Syndrome (3 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TBX20	T-Box 20	Protein Coding	400	Pathogenic ⁶
2	GJA1	Gap Junction Protein Alpha 1	Protein Coding	69.52	Susceptibility factor ⁵⁹ DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
3	NKX2-5	NK2 Homeobox 5	Protein Coding	68.54	Susceptibility factor ⁵⁹ DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
4	HAND1	Heart And Neural Crest Derivatives Expressed 1	Protein Coding	33.59	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)
5	NOTCH1	Notch 1	Protein Coding	32.9	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
6	FOXL1	Forkhead Box L1	Protein Coding	22.85	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	FOXP1	Forkhead Box P1	Protein Coding	22.19	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
8	FOXC2	Forkhead Box C2	Protein Coding	21.86	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	TNNI3	Troponin I3, Cardiac Type	Protein Coding	21.55	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	EHMT1	Euchromatic Histone Lysine Methyltransferase 1	Protein Coding	21.39	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	CDH2	Cadherin 2	Protein Coding	21.14	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	MYH6	Myosin Heavy Chain 6	Protein Coding	20.71	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	GATA5	GATA Binding Protein 5	Protein Coding	18.14	GeneCards inferred via : Disorders (show sections)
14	SMAD6	SMAD Family Member 6	Protein Coding	18.14	GeneCards inferred via : Disorders (show sections)
15	NKX2-6	NK2 Homeobox 6	Protein Coding	17.68	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
16	NPPB	Natriuretic Peptide B	Protein Coding	17.27	GeneCards inferred via : Publications (show sections)
17	NPPA	Natriuretic Peptide A	Protein Coding	17.27	GeneCards inferred via : Publications (show sections)
18	LEP	Leptin	Protein Coding	17.27	GeneCards inferred via : Publications (show sections)
19	XDH	Xanthine Dehydrogenase	Protein Coding	17.27	GeneCards inferred via : Publications (show sections)
20	PCDHA9	Protocadherin Alpha 9	Protein Coding	17.06	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

Sources

Variations for Hypoplastic Left Heart Syndrome

ClinVar genetic disease variations for Hypoplastic Left Heart Syndrome:

⁶

(show all 11)

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1		46;XY;inv(10)(q21.2q22.3)pat	inversion	Likely pathogenic
2	HAND1	NM_004821.2(HAND1): c.531G> C (p.Arg177=)	single nucleotide variant	Benign	rs34198899	GRCh37	Chromosome 5, 153857038: 153857038
3	HAND1	NM_004821.2(HAND1): c.531G> C (p.Arg177=)	single nucleotide variant	Benign	rs34198899	GRCh38	Chromosome 5, 154477478: 154477478
4	HAND1	NM_004821.2(HAND1): c.468T> G (p.Ser156=)	single nucleotide variant	Benign	rs34402828	GRCh37	Chromosome 5, 153857101: 153857101
5	HAND1	NM_004821.2(HAND1): c.468T> G (p.Ser156=)	single nucleotide variant	Benign	rs34402828	GRCh38	Chromosome 5, 154477541: 154477541
6	TBX20	NM_001077653.2(TBX20): c.995delC (p.Pro332Glnfs)	deletion	Pathogenic		GRCh37	Chromosome 7, 35244090: 35244090
7	TBX20	NM_001077653.2(TBX20): c.995delC (p.Pro332Glnfs)	deletion	Pathogenic		GRCh38	Chromosome 7, 35204478: 35204478
8	HAND1	NM_004821.2(HAND1): c.180G> A (p.Gly60=)	single nucleotide variant	Benign	rs369386099	GRCh37	Chromosome 5, 153857389: 153857389
9	HAND1	NM_004821.2(HAND1): c.180G> A (p.Gly60=)	single nucleotide variant	Benign	rs369386099	GRCh38	Chromosome 5, 154477829: 154477829
10	HAND1	NM_004821.2(HAND1): c.257A> T (p.Glu86Val)	single nucleotide variant	Uncertain significance		GRCh37	Chromosome 5, 153857312: 153857312
11	HAND1	NM_004821.2(HAND1): c.257A> T (p.Glu86Val)	single nucleotide variant	Uncertain significance		GRCh38	Chromosome 5, 154477752: 154477752

Copy number variations for Hypoplastic Left Heart Syndrome from CNVD:

⁷ (show all 21)

#	CNVD ID	Chromosom	Start	End	Type	CNVD Disease
1	14068	1	103830000	103950000	Deletion	Hypoplastic left heart syndrome
2	21589	1	159750000	159870000	Duplication	Hypoplastic left heart syndrome
3	25802	1	194970000	195150000	Deletion	Hypoplastic left heart syndrome
4	42872	10	41970000	42150000	Deletion	Hypoplastic left heart syndrome
5	43118	10	44550000	44670000	Duplication	Hypoplastic left heart syndrome
6	66481	12	29999	149999	Duplication	Hypoplastic left heart syndrome
7	67101	12	36330000	36690000	Duplication	Hypoplastic left heart syndrome
8	75411	13	19710000	19950000	Deletion	Hypoplastic left heart syndrome
9	86813	14	65790000	65910000	Deletion	Hypoplastic left heart syndrome
10	89821	15	19110000	20070000	Duplication	Hypoplastic left heart syndrome
11	90056	15	19890000	20010000	Duplication	Hypoplastic left heart syndrome
12	90977	15	26730000	26910000	Duplication	Hypoplastic left heart syndrome
13	105401	16	79469999	80189999	Duplication	Hypoplastic left heart syndrome
14	113091	17	41730000	41910000	Duplication	Hypoplastic left heart syndrome
15	135332	2	113909999	114089999	Deletion	Hypoplastic left heart syndrome
16	157162	21	13530000	13650000	Deletion	Hypoplastic left heart syndrome
17	157211	21	13949999	14129999	Deletion	Hypoplastic left heart syndrome
18	157986	21	28170000	28230000	Deletion	Hypoplastic left heart syndrome
19	160077	21	9750000	9870000	Deletion	Hypoplastic left heart syndrome
20	213658	6	49949999	50009999	Duplication	Hypoplastic left heart syndrome
21	217526	7	101789999	101909999	Duplication	Hypoplastic left heart syndrome

Sources

Expression for Hypoplastic Left Heart Syndrome

Search GEO for disease gene expression data for Hypoplastic Left Heart Syndrome.

Sources

Pathways for Hypoplastic Left Heart Syndrome

Pathways related to Hypoplastic Left Heart Syndrome according to KEGG:

³⁷

#	Name	Kegg Source Accession
1	Gap junction	hsa04540

Pathways related to Hypoplastic Left Heart Syndrome according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Mesodermal Commitment Pathway ¹ Show member pathways Endoderm Differentiation ¹	12.19	FOXC2 HAND1 NOTCH1 SMAD6
2	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.68	GJA1 NKX2-5 NOTCH1 TNNI3
3	Neural Crest Differentiation ¹	11.55	CDH2 HAND1 NOTCH1
4	Cardiac Progenitor Differentiation ¹	11.08	MYH6 NKX2-5 NOTCH1 TBX20 TNNI3
5	Heart Development ¹	10.68	FOXC2 HAND1 NKX2-5 NOTCH1 TBX20
6	Cardiomyocyte Differentiation through BMP Receptors ⁶⁴	10.67	NKX2-5 NPPA NPPB
7	HOP Signaling ⁶⁴	10.1	NKX2-5 NPPA

Sources

GO Terms for Hypoplastic Left Heart Syndrome

Cellular components related to Hypoplastic Left Heart Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein-containing complex	GO:0032991	9.35	GJA1 NKX2-5 NPPA NPPB SMAD6
2	contractile fiber	GO:0043292	9.16	GJA1 TNNI3
3	fascia adherens	GO:0005916	8.62	CDH2 GJA1

Biological processes related to Hypoplastic Left Heart Syndrome according to GeneCards Suite gene sharing:

(show all 48)

#	Name	GO ID	Score	Top Affiliating Genes
1	in utero embryonic development	GO:0001701	9.94	GJA1 HAND1 MYH6 NOTCH1
2	negative regulation of cell growth	GO:0030308	9.87	GJA1 NPPA NPPB
3	BMP signaling pathway	GO:0030509	9.85	MYH6 NKX2-5 SMAD6
4	muscle contraction	GO:0006936	9.83	GJA1 MYH6 TBX20 TNNI3
5	regulation of cardiac conduction	GO:1903779	9.8	NKX2-5 NPPA TNNI3
6	cardiac muscle contraction	GO:0060048	9.77	MYH6 NKX2-5 TNNI3
7	regulation of blood pressure	GO:0008217	9.73	LEP MYH6 NPPA NPPB
8	neuronal stem cell population maintenance	GO:0097150	9.7	CDH2 NOTCH1
9	negative regulation of ossification	GO:0030279	9.7	NOTCH1 SMAD6
10	pharyngeal system development	GO:0060037	9.69	NKX2-5 NKX2-6
11	glial cell differentiation	GO:0010001	9.69	CDH2 NOTCH1
12	negative regulation of myotube differentiation	GO:0010832	9.69	NKX2-5 NOTCH1
13	endocardial cushion morphogenesis	GO:0003203	9.68	NOTCH1 TBX20
14	ventricular trabecula myocardium morphogenesis	GO:0003222	9.68	NKX2-5 NOTCH1
15	cardiac muscle hypertrophy in response to stress	GO:0014898	9.68	MYH6 NPPA
16	atrial septum morphogenesis	GO:0060413	9.67	NKX2-5 TBX20
17	heart contraction	GO:0060047	9.67	NKX2-5 TNNI3
18	outflow tract septum morphogenesis	GO:0003148	9.67	NKX2-5 SMAD6 TBX20
19	ventricular cardiac muscle cell development	GO:0055015	9.66	NKX2-5 NKX2-6
20	cardiac septum morphogenesis	GO:0060411	9.66	HAND1 NOTCH1
21	pulmonary valve morphogenesis	GO:0003184	9.65	NOTCH1 SMAD6
22	cardiac ventricle morphogenesis	GO:0003208	9.65	NKX2-5 NOTCH1
23	receptor guanylyl cyclase signaling pathway	GO:0007168	9.65	NPPA NPPB
24	pericardium morphogenesis	GO:0003344	9.64	NOTCH1 TBX20
25	regulation of bone remodeling	GO:0046850	9.63	GJA1 LEP
26	regulation of blood vessel size	GO:0050880	9.63	FOXC2 NPPA NPPB
27	aortic valve morphogenesis	GO:0003180	9.62	NOTCH1 TBX20
28	negative regulation of SMAD protein complex assembly	GO:0010991	9.61	SMAD6 TBX20
29	heart development	GO:0007507	9.61	FOXC2 FOXL1 GATA5 GJA1 HAND1 NKX2-5
30	glomerular mesangial cell development	GO:0072144	9.58	FOXC2 NOTCH1
31	cardiac right ventricle formation	GO:0003219	9.58	HAND1 NOTCH1
32	cardiac muscle tissue morphogenesis	GO:0055008	9.58	NKX2-5 NOTCH1 TBX20
33	atrioventricular node development	GO:0003162	9.56	NKX2-5 NOTCH1
34	ventricular cardiac muscle tissue morphogenesis	GO:0055010	9.56	FOXC2 HAND1 MYH6 TNNI3
35	atrial cardiac muscle cell development	GO:0055014	9.55	NKX2-5 NKX2-6
36	heart looping	GO:0001947	9.55	GJA1 HAND1 NKX2-5 NOTCH1 TBX20
37	adult heart development	GO:0007512	9.54	GJA1 MYH6 NKX2-5
38	cardiac muscle cell proliferation	GO:0060038	9.5	FOXC2 NKX2-5 NOTCH1
39	cardiac chamber formation	GO:0003207	9.48	NOTCH1 TBX20
40	embryonic heart tube development	GO:0035050	9.1	FOXC2 GJA1 HAND1 NKX2-5 NKX2-6 TBX20
41	transcription, DNA-templated	GO:0006351	10.32	FOXC2 FOXL1 FOXP1 GATA5 HAND1 NKX2-6
42	regulation of transcription, DNA-templated	GO:0006355	10.32	FOXC2 FOXL1 FOXP1 GATA5 HAND1 NKX2-5
43	cell differentiation	GO:0030154	10.16	FOXC2 FOXL1 FOXP1 HAND1 NKX2-5 NKX2-6
44	multicellular organism development	GO:0007275	10.14	CDH2 FOXC2 FOXL1 HAND1 NKX2-5 NKX2-6
45	transcription by RNA polymerase II	GO:0006366	10.09	FOXC2 GATA5 HAND1 NKX2-5 TBX20
46	positive regulation of transcription, DNA-templated	GO:0045893	10.07	FOXC2 GATA5 HAND1 NKX2-5 NOTCH1 TBX20
47	negative regulation of transcription by RNA polymerase II	GO:0000122	10.05	EHMT1 FOXC2 HAND1 LEP NKX2-5 NOTCH1
48	negative regulation of transcription, DNA-templated	GO:0045892	10.04	EHMT1 FOXP1 HAND1 NKX2-5 NOTCH1 TBX20

Molecular functions related to Hypoplastic Left Heart Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	RNA polymerase II transcription factor activity, sequence-specific DNA binding	GO:0000981	9.81	FOXC2 FOXL1 FOXP1 GATA5 HAND1 NKX2-5
2	transcription regulatory region DNA binding	GO:0044212	9.65	FOXC2 GATA5 HAND1 NKX2-5 SMAD6
3	hormone activity	GO:0005179	9.63	LEP NPPA NPPB
4	DNA binding transcription factor activity	GO:0003700	9.61	FOXC2 FOXL1 FOXP1 GATA5 NKX2-5 NKX2-6
5	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	GO:0003705	9.54	FOXC2 GATA5 NKX2-5
6	transcriptional activator activity, RNA polymerase II transcription factor binding	GO:0001190	9.48	NKX2-5 NOTCH1
7	peptide hormone receptor binding	GO:0051428	9.43	LEP NPPA
8	hormone receptor binding	GO:0051427	9.32	NPPA NPPB
9	sequence-specific DNA binding	GO:0043565	9.23	FOXC2 FOXL1 FOXP1 GATA5 HAND1 NKX2-5
10	DNA binding	GO:0003677	10.06	FOXC2 FOXL1 FOXP1 GATA5 HAND1 NKX2-5

Sources

Sources for Hypoplastic Left Heart Syndrome

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

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Hypoplastic Left Heart Syndrome

Aliases & Classifications for Hypoplastic Left Heart Syndrome

MalaCards integrated aliases for Hypoplastic Left Heart Syndrome:

Characteristics:

Orphanet epidemiological data:

Classifications:

External Ids:

Summaries for Hypoplastic Left Heart Syndrome

Related Diseases for Hypoplastic Left Heart Syndrome

Diseases in the Hypoplastic Left Heart Syndrome family:

Diseases related to Hypoplastic Left Heart Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Hypoplastic Left Heart Syndrome:

Symptoms & Phenotypes for Hypoplastic Left Heart Syndrome

Human phenotypes related to Hypoplastic Left Heart Syndrome:

MGI Mouse Phenotypes related to Hypoplastic Left Heart Syndrome:

Drugs & Therapeutics for Hypoplastic Left Heart Syndrome

Drugs for Hypoplastic Left Heart Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Cell-based therapeutics:

Cochrane evidence based reviews: hypoplastic left heart syndrome

Genetic Tests for Hypoplastic Left Heart Syndrome

Genetic tests related to Hypoplastic Left Heart Syndrome:

Anatomical Context for Hypoplastic Left Heart Syndrome

MalaCards organs/tissues related to Hypoplastic Left Heart Syndrome:

Publications for Hypoplastic Left Heart Syndrome

Articles related to Hypoplastic Left Heart Syndrome:

Genes for Hypoplastic Left Heart Syndrome

Genes related to Hypoplastic Left Heart Syndrome (3 elite genes):

Variations for Hypoplastic Left Heart Syndrome

ClinVar genetic disease variations for Hypoplastic Left Heart Syndrome:

Copy number variations for Hypoplastic Left Heart Syndrome from CNVD:

Expression for Hypoplastic Left Heart Syndrome

Pathways for Hypoplastic Left Heart Syndrome

Pathways related to Hypoplastic Left Heart Syndrome according to KEGG:

Pathways related to Hypoplastic Left Heart Syndrome according to GeneCards Suite gene sharing:

GO Terms for Hypoplastic Left Heart Syndrome

Cellular components related to Hypoplastic Left Heart Syndrome according to GeneCards Suite gene sharing:

Biological processes related to Hypoplastic Left Heart Syndrome according to GeneCards Suite gene sharing:

Molecular functions related to Hypoplastic Left Heart Syndrome according to GeneCards Suite gene sharing:

Sources for Hypoplastic Left Heart Syndrome

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :