Aliases & Classifications for Hypopyon

MalaCards integrated aliases for Hypopyon:

Name: Hypopyon 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10443
ICD10 33 H20.05
ICD9CM 35 364.05
NCIt 50 C50593
SNOMED-CT 68 87807004
UMLS 73 C0020641

Summaries for Hypopyon

MalaCards based summary : Hypopyon is related to corneal dystrophy, band-shaped and hypopyon ulcer. An important gene associated with Hypopyon is MRAP (Melanocortin 2 Receptor Accessory Protein), and among its related pathways/superpathways are Glycerophospholipid biosynthesis and Adipogenesis. The drugs Ethinyl Estradiol and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include eye, myeloid and t cells, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 Hypopyon is a medical condition involving inflammatory cells in the anterior chamber of the... more...

Related Diseases for Hypopyon

Diseases related to Hypopyon via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 corneal dystrophy, band-shaped 29.4 MRAP EPHA5
2 hypopyon ulcer 12.3
3 behcet syndrome 11.1
4 uveitis 10.6
5 leukemia 10.4
6 endophthalmitis 10.3
7 anterior uveitis 10.3
8 lymphoma 10.2
9 myeloid leukemia 10.2
10 lymphocytic leukemia 10.1
11 iritis 10.1
12 leukemia, acute myeloid 10.1
13 leukemia, acute lymphoblastic 10.1
14 relapsing polychondritis 10.1
15 acquired immunodeficiency syndrome 10.1
16 iridocyclitis 10.1
17 panuveitis 10.0
18 psoriasis 10.0
19 spondyloarthropathy 1 9.9
20 retinal detachment 9.9
21 acute leukemia 9.9
22 arthritis 9.9
23 klebsiella pneumonia 9.9
24 scleritis 9.9
25 acute closed-angle glaucoma 9.9
26 pneumonia 9.9
27 spondylitis 9.9
28 corneal ulcer 9.9
29 tuberculous uveitis 9.9
30 fungal keratitis 9.9
31 keratitis, hereditary 9.8
32 systemic lupus erythematosus 9.8
33 pemphigus vulgaris, familial 9.8
34 lymphoma, hodgkin, classic 9.8
35 mycosis fungoides 9.8
36 lymphoma, non-hodgkin, familial 9.8
37 psoriatic arthritis 9.8
38 myocardial infarction 9.8
39 acute lymphocytic leukemia 9.8
40 acute myocardial infarction 9.8
41 b-cell lymphomas 9.8
42 cataract 9.8
43 crohn's disease 9.8
44 intraocular lymphoma 9.8
45 keratopathy 9.8
46 pemphigus foliaceus 9.8
47 pemphigus vulgaris 9.8
48 ulcerative colitis 9.8
49 colitis 9.8
50 epithelial basement membrane dystrophy 9.8

Comorbidity relations with Hypopyon via Phenotypic Disease Network (PDN):


Acute Endophthalmitis Purulent Endophthalmitis

Graphical network of the top 20 diseases related to Hypopyon:



Diseases related to Hypopyon

Symptoms & Phenotypes for Hypopyon

GenomeRNAi Phenotypes related to Hypopyon according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.7 DHX9
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.7 EPHA5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.7 DHX9
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.7 EPHA5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.7 EPHA5
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.7 DHX9 EPHA5
7 Decreased viability after Maraba virus infection GR00252-A-1 9.5 EPHA5
8 Decreased viability after Maraba virus infection GR00252-A-2 9.5 CA8 EPHA5 LPIN2
9 Decreased viability after Maraba virus infection GR00252-A-3 9.5 CA8 EPHA5 LPIN2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.32 EPHA5
11 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.32 EPHA5
12 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.32 DHX9 EPHA5
13 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.32 DHX9
14 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.32 DHX9 EPHA5
15 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.32 EPHA5
16 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.32 DHX9
17 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.32 EPHA5

Drugs & Therapeutics for Hypopyon

Drugs for Hypopyon (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3 1177-87-3
3
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
4
Polyestradiol phosphate Approved Phase 4 28014-46-2
5
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
6
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3 50-02-2 5743
7
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
8 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
9 Hormones Phase 4,Phase 3
10 Estradiol 3-benzoate Phase 4
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
12 Antineoplastic Agents, Hormonal Phase 4,Phase 3
13 Anti-Bacterial Agents Phase 4,Phase 3
14 Anti-Infective Agents Phase 4,Phase 3
15 Estradiol 17 beta-cypionate Phase 4
16 HIV Protease Inhibitors Phase 4
17 Fluoroquinolones Phase 4
18 Pharmaceutical Solutions Phase 4,Phase 3
19 Nucleic Acid Synthesis Inhibitors Phase 4
20 Anti-Inflammatory Agents Phase 4,Phase 3
21 Norgestimate, ethinyl estradiol drug combination Phase 4
22 Topoisomerase Inhibitors Phase 4
23 glucocorticoids Phase 4,Phase 3
24 Contraceptives, Oral Phase 4
25 Hormone Antagonists Phase 4,Phase 3
26 Contraceptives, Oral, Combined Phase 4
27
protease inhibitors Phase 4
28 Antiemetics Phase 4,Phase 3
29 BB 1101 Phase 4,Phase 3
30 Peripheral Nervous System Agents Phase 4,Phase 3
31 Ophthalmic Solutions Phase 4,Phase 3
32 Autonomic Agents Phase 4,Phase 3
33 Contraceptive Agents Phase 4
34 Gastrointestinal Agents Phase 4,Phase 3
35
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
36
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
37
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
38
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
39
Fluprednisolone Approved Phase 3 53-34-9
40
Difluprednate Approved Phase 3 23674-86-4 443936
41
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
42
Iodine Approved, Investigational Phase 3 7553-56-2 807
43
Povidone-iodine Approved Phase 3 25655-41-8
44
Povidone Approved Phase 3 9003-39-8
45
Natamycin Approved Phase 3 7681-93-8 5281099
46
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
47 Prednisolone acetate Phase 3
48 Neuroprotective Agents Phase 3
49 Protective Agents Phase 3
50 Methylprednisolone acetate Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Efficacy and Safety of Vigadexa in Treating Inflammation and Infection Post-cataract Surgery Completed NCT00870103 Phase 4 Vigadexa (moxifloxacin 0.5% and dexamethasone 0.1%) eye drops
2 Aurolab Hydrophobic Foldable Intraocular Lens Study Completed NCT00449267 Phase 4
3 The Efficacy and Safety of IBI-10090 for the Treatment of Inflammation Associated With Cataract Surgery Completed NCT02006888 Phase 3 IBI-10090;Placebo
4 Difluprednate Pediatric Study for the Treatment of Inflammation Post-Cataract Surgery Completed NCT01124045 Phase 3 Difluprednate ophthalmic emulsion, 0.05%;Prednisolone acetate ophthalmic suspension, 1.0%
5 Safety and Efficacy of Difluprednate 0.05% for the Treatment of Anterior Uveitis Completed NCT01201798 Phase 3 Difluprednate 0.05% ophthalmic emulsion;Prednisolone acetate 1.0% ophthalmic suspension
6 Safety and Efficacy of Phenylephrine 2.5%-Tropicamide 1% Microdose Ophthalmic Solution for Pupil Dilation Recruiting NCT03751098 Phase 3 Phenylephrine 2.5%-tropicamide 1% ophthalmic solution;Placebo
7 Safety and Efficacy of Phenylephrine 2.5%-Tropicamide 1% Microdose Ophthalmic Solution for Pupil Dilation Active, not recruiting NCT03751631 Phase 3 Phenylephrine 2.5%-tropicamide 1% ophthalmic solution;Phenylephrine 2.5% ophthalmic solution;Tropicamide 1% ophthalmic solution
8 A Clinical Trial of the Treatment of Fungal Corneal Ulcers With Povidone-Iodine Terminated NCT00516399 Phase 3 povidone-iodine 1.25% ophthalmic solution;natamycin ophthalmic suspension, USP 5%
9 Effect of Tetracaine on Pain Management and Corneal Healing in Patients With Acute Corneal Abrasion Withdrawn NCT02483897 Phase 3 Tetracaine 0.5% ophthalmic drops;Normal Saline placebo drops
10 Treatment of the Bilateral Severe Uveitis by IVT of Regulator T-cells: Study of Tolerance of Dose Suspended NCT02494492 Phase 1, Phase 2

Search NIH Clinical Center for Hypopyon

Genetic Tests for Hypopyon

Anatomical Context for Hypopyon

MalaCards organs/tissues related to Hypopyon:

41
Eye, Myeloid, T Cells, Testes, B Cells, Neutrophil

Publications for Hypopyon

Articles related to Hypopyon:

(show top 50) (show all 203)
# Title Authors Year
1
A rare case of superior hypopyon with iris neovascularization. ( 29563712 )
2018
2
Presumably contaminated intravenous infusion-induced Aspergillus terreus endogenous endophthalmitis presenting with posterior hypopyon. ( 29582833 )
2018
3
Hypopyon pustules of Sneddon-Wilkenson disease. ( 30414189 )
2018
4
Unilateral bullous retinal detachment in a child with acute lymphoblastic leukaemia, and hypopyon as the first sign of leukaemic relapse. ( 30364122 )
2018
5
Presumed Tuberculous Sclerokeratitis Presenting with Hypopyon. ( 30148654 )
2018
6
Treatment of Epithelial Downgrowth Masquerading as Unilateral Hypopyon Uveitis in a HLA-B27+ Individual. ( 27598054 )
2018
7
Inverse hypopyon (hyperoleon) at the posterior segment in pathological myopia. ( 29183904 )
2017
8
In response to: &amp;quot;Ranjan, P, Joshi P, and Gupta M. Staphylococcus aureus induced endogenous endophthalmitis with pink hypopyon.&amp;quot; ( 28448724 )
2017
9
Hemorrhagic hypopyon as presenting feature of intravascular lymphoma, a case report. ( 29070018 )
2017
10
Inverse Hypopyon. ( 28219502 )
2017
11
Bilateral Severe Sterile Inflammation with Hypopyon after Simultaneous Intravitreal Triamcinolone Acetonide and Aflibercept Injection in a Patient with Bilateral Marked Rubeosis Associated with Ocular Ischemic Syndrome. ( 28386497 )
2017
12
Tuberculous uveitis presenting as pigmented hypopyon - A case report. ( 29260068 )
2017
13
Primary adrenal T-cell lymphoma in a young adult presented with pseudo-hypopyon: a case report and literature review. ( 29043242 )
2017
14
Bilateral Hypopyon Uveitis in Chronic Myeloid Leukemia. ( 29344492 )
2017
15
Child with hypopyon. ( 29054898 )
2017
16
Hypopyon complicating the course of anterior uveitis in a patient with Behcet's syndrome. ( 27648274 )
2016
17
Ochrobactrum anthropi Keratitis with Focal Descemet's Membrane Detachment and Intracorneal Hypopyon. ( 27777806 )
2016
18
IMAGES IN CLINICAL MEDICINE. Hypopyon and Klebsiella Sepsis. ( 27355556 )
2016
19
Staphylococcus aureus Induced Endogenous Endophthalmitis with Pink Hypopyon. ( 27937098 )
2016
20
Hypopyon uveitis following panretinal photocoagulation. ( 27381997 )
2016
21
Inverted hypopyon in the eye. ( 26887888 )
2016
22
Unusual presentation of subretinal cysticercosis with hypopyon uveitis. ( 25871533 )
2015
23
Medical image. Leukaemic hypopyon. ( 25899495 )
2015
24
Pink hypopyon in a patient with Serratia marcescens corneal ulceration. ( 25861400 )
2015
25
Intraocular Relapse with Hypopyon and Retinal Infiltrates after Chemotherapy and Peripheral Blood Stem Cell Transplantation for Extranodal NK/T-Cell Lymphoma. ( 26763364 )
2015
26
Cytomegalovirus Uveitis with Hypopyon Mimicking Bacterial Endophthalmitis. ( 26078897 )
2015
27
Severe staphylococcal marginal keratitis presenting with hypopyon. ( 26286911 )
2015
28
Alternaria keratitis and hypopyon after clear-cornea phacoemulsification. ( 24461506 )
2014
29
When the eye gives it all: diagnosis of relapsing acute myeloblastic leukemia with anterior chamber tap of a chronic hypopyon. ( 25165787 )
2014
30
A case of panuveitis with hypopyon due to presumed ocular leishmaniasis in a HIV patient. ( 26530344 )
2014
31
Pigmented hypopyon in association with Listeria monocytogenes endopthalmitis: an interesting case report following refractive surgery procedure with literature review. ( 24669144 )
2014
32
Minimal trephination penetrating keratoplasty for severe fungal keratitis complicated with hypopyon. ( 24314417 )
2013
33
Hypopyon as the first sign of relapse in acute lymphoblastic leukaemia. ( 23400411 )
2013
34
Hypopyon and pseudoendophthalmitis 1 month after vitrectomy for retinal detachment with subretinal hemorrhage. ( 23676232 )
2013
35
'Hypopyon' in the anterior chamber: unilateral ocular relapse of acute myeloid leukaemia in a 2-year-old girl. ( 23750915 )
2013
36
Leukemic hypopyon in acute myeloid leukemia. ( 23225088 )
2013
37
Hypopyon uveitis-a rare presentation of intraocular tuberculosis. ( 23617801 )
2013
38
Inverted hypopyon in the posterior pole. ( 23538580 )
2013
39
Bilateral Hypopyon Uveitis Secondary to Mycosis Fungoides with Sezary Syndrome. ( 24131357 )
2013
40
Hypopyon Uveitis Following Panretinal Photocoagulation in a Diabetic Patient. ( 23947383 )
2013
41
Recurrent anterior uveitis with hypopyon revealing relapsing polychondritis. ( 23154727 )
2012
42
Hypopyon-like features: new dermoscopic criteria in the differential diagnosis of cutaneous lymphangioma circumscriptum and haemangiomas? ( 21645121 )
2012
43
Rifabutin-associated hypopyon uveitis and retinal vasculitis with a history of acute myeloid leukemia. ( 22311604 )
2012
44
Hypopyon in the context of tuberculous uveitis. ( 22229955 )
2012
45
Hypopyon in patients with fungal keratitis. ( 22490405 )
2012
46
A case of congenital corneal anesthesia with hypopyon in china. ( 22678876 )
2012
47
Hypopyon uveitis following LASIK in a patient with ulcerative colitis. ( 22869236 )
2012
48
Hypopyon uveitis in ankylosing spondylitis. ( 23013851 )
2012
49
Relapsing acute myeloid leukemia presenting as hypopyon uveitis. ( 21836350 )
2011
50
Anterior segment intraocular metallic foreign body causing chronic hypopyon uveitis. ( 21484173 )
2011

Variations for Hypopyon

Expression for Hypopyon

Search GEO for disease gene expression data for Hypopyon.

Pathways for Hypopyon

GO Terms for Hypopyon

Cellular components related to Hypopyon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.46 LPIN1 LPIN2 MRAP PITPNM1
2 cytoplasmic ribonucleoprotein granule GO:0036464 8.96 DHX9 PITPNM1
3 endoplasmic reticulum membrane GO:0005789 8.92 LPIN1 LPIN2 MRAP PITPNM1

Biological processes related to Hypopyon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.54 LPIN1 LPIN2 PITPNM1
2 cellular response to insulin stimulus GO:0032869 9.32 LPIN1 LPIN2
3 phosphatidylcholine biosynthetic process GO:0006656 9.26 LPIN1 LPIN2
4 triglyceride biosynthetic process GO:0019432 9.16 LPIN1 LPIN2
5 fatty acid catabolic process GO:0009062 8.96 LPIN1 LPIN2
6 phosphatidylethanolamine biosynthetic process GO:0006646 8.62 LPIN1 LPIN2

Molecular functions related to Hypopyon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription coactivator activity GO:0003713 9.13 DHX9 LPIN1 LPIN2
2 phosphatidate phosphatase activity GO:0008195 8.62 LPIN1 LPIN2

Sources for Hypopyon

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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