Aliases & Classifications for Hypopyon

MalaCards integrated aliases for Hypopyon:

Name: Hypopyon 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10443
ICD9CM 34 364.05
NCIt 49 C50593
SNOMED-CT 67 87807004
ICD10 32 H20.05
UMLS 71 C0020641

Summaries for Hypopyon

MalaCards based summary : Hypopyon is related to corneal dystrophy, band-shaped and retinal vasculitis. An important gene associated with Hypopyon is MRAP (Melanocortin 2 Receptor Accessory Protein), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Human cytomegalovirus infection. The drugs Miconazole and Natamycin have been mentioned in the context of this disorder. Affiliated tissues include eye, myeloid and lung.

Wikipedia : 74 Hypopyon is a medical condition involving inflammatory cells in the anterior chamber of the... more...

Related Diseases for Hypopyon

Diseases related to Hypopyon via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 476)
# Related Disease Score Top Affiliating Genes
1 corneal dystrophy, band-shaped 30.5 TNFRSF1B MRAP
2 retinal vasculitis 30.4 TNFRSF1B RBP3 MRAP
3 chronic endophthalmitis 30.4 RBP3 MRAP ASPRV1
4 orbital cellulitis 30.3 MPDU1 CRP
5 neuroretinitis 30.3 MRAP CRP CD4
6 pyomyositis 30.2 CRP CD4
7 uveitis 30.2 TNFRSF1B RBP3 IL6 IL17A HLA-B
8 klebsiella pneumonia 30.1 IL17A CRP
9 pars planitis 30.0 MRAP IL1RN HLA-B
10 relapsing polychondritis 30.0 IL6 IL17A CRP
11 keratitis, hereditary 30.0 VEGFA IL6 IL17A CD4
12 eales disease 29.9 VEGFA RBP3 IL6
13 miliary tuberculosis 29.9 TNFRSF1B CRP CD4
14 macular retinal edema 29.9 VEGFA TNFRSF1B MRAP IL6
15 endophthalmitis 29.9 VEGFA MRAP IL6 CRP CD4 ASPRV1
16 intermediate uveitis 29.8 MRAP IL6 HLA-B
17 choroiditis 29.8 VEGFA RBP3 MRAP CD4
18 bronchitis 29.7 VEGFA IL6 CRP
19 cellulitis 29.7 IL6 CRP CD4
20 rubella 29.6 TNFRSF1B IL6 HLA-B
21 scleritis 29.6 TNFRSF1B MRAP IL1RN CRP
22 acquired immunodeficiency syndrome 29.5 TNFRSF1B IL6 HLA-B CRP CD4
23 pulmonary tuberculosis 29.5 IL6 IL17A CRP
24 spondyloarthropathy 29.4 IL6 IL17A HLA-B
25 herpes zoster 29.4 TNFRSF1B HLA-B CRP CD4
26 optic papillitis 29.4 TNFRSF1B RBP3 MRAP CRP CD4
27 iritis 29.4 TNFRSF1B MRAP IL6 HLA-B CRP CD4
28 leprosy 3 29.3 IL6 IL17A CD4
29 pericarditis 29.2 IL6 IL1RN CRP
30 pustulosis of palm and sole 29.2 TNFRSF1B MRAP IL1RN IL17A
31 endocarditis 29.1 TNFRSF1B IL6 IL17A CRP
32 vasculitis 28.9 TNFRSF1B IL6 IL17A HLA-B CRP
33 juvenile rheumatoid arthritis 28.9 TNFRSF1B IL6 IL1RN CRP
34 arthropathy 28.9 IL6 IL1RN HLA-B CRP
35 psoriasis 28.7 TNFRSF1B IL6 IL17A HLA-B CD4
36 sarcoidosis 1 28.7 TNFRSF1B MRAP IL1RN CRP CD4
37 meningitis 28.7 VEGFA IL6 IL17A HLA-B CRP
38 crohn's disease 28.6 TNFRSF1B IL6 IL17A CRP CD4
39 ulcerative colitis 28.5 IL6 IL1RN IL17A CRP
40 behcet syndrome 28.4 UBAC2 TNFRSF1B RBP3 MRAP KLRC4 IL6
41 spondyloarthropathy 1 28.4 TNFRSF1B MRAP IL1RN IL17A HLA-B CRP
42 iridocyclitis 28.2 UBAC2 TNFRSF1B RBP3 MRAP IL6 IL17A
43 spondylitis 28.1 TNFRSF1B IL6 IL1RN IL17A HLA-B CRP
44 chorioretinitis 28.0 VEGFA TNFRSF1B RBP3 MRAP IL6 IL17A
45 pneumonia 28.0 VEGFA TNFRSF1B IL6 IL1RN IL17A CRP
46 psoriatic arthritis 27.6 VEGFA TNFRSF1B IL6 IL1RN IL17A HLA-B
47 eye disease 27.4 VEGFA RBP3 MRAP IL6 IL1RN IL17A
48 inflammatory bowel disease 27.3 VEGFA TNFRSF1B IL6 IL1RN IL17A HLA-B
49 systemic lupus erythematosus 27.2 VEGFA TNFRSF1B IL6 IL1RN IL17A CRP
50 panuveitis 26.6 VEGFA TNFRSF1B RBP3 MRAP IL6 IL1RN

Comorbidity relations with Hypopyon via Phenotypic Disease Network (PDN):


Acute Endophthalmitis Purulent Endophthalmitis

Graphical network of the top 20 diseases related to Hypopyon:



Diseases related to Hypopyon

Symptoms & Phenotypes for Hypopyon

Drugs & Therapeutics for Hypopyon

Drugs for Hypopyon (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
2
Natamycin Approved Phase 2, Phase 3 7681-93-8 5281099
3
Voriconazole Approved Phase 2, Phase 3 137234-62-9 71616
4
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
5
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
6
Moxifloxacin Approved, Investigational Phase 3 151096-09-2, 354812-41-2 152946
7
Polyestradiol phosphate Approved Phase 3 28014-46-2
8
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
9 Anti-Infective Agents, Local Phase 2, Phase 3
10 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
11 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3
12 Pharmaceutical Solutions Phase 2, Phase 3
13 Hormone Antagonists Phase 2, Phase 3
14 Ophthalmic Solutions Phase 2, Phase 3
15 Antifungal Agents Phase 2, Phase 3
16 Steroid Synthesis Inhibitors Phase 2, Phase 3
17 Hormones Phase 2, Phase 3
18 Anti-Infective Agents Phase 3
19 Contraceptive Agents Phase 3
20 Estradiol 17 beta-cypionate Phase 3
21 Norgestimate, ethinyl estradiol drug combination Phase 3
22 Anti-Bacterial Agents Phase 3
23 Topoisomerase Inhibitors Phase 3
24 Contraceptives, Oral, Combined Phase 3
25 Estradiol 3-benzoate Phase 3
26 Contraceptives, Oral Phase 3
27
Iodine Approved, Investigational Phase 2 7553-56-2 807
28
Povidone Approved Phase 2 9003-39-8
29
Povidone-iodine Approved Phase 2 25655-41-8
30 Micronutrients Phase 2
31 Trace Elements Phase 2
32 Plasma Substitutes Phase 2
33 Nutrients Phase 2
34 cadexomer iodine Phase 2
35 Blood Substitutes Phase 2
36 Polymethyl Methacrylate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Combination Treatment of 5% Natamycin and 1% Voriconazole in Fungal Keratitis: a Prospective Randomized Double Masked Clinical Trial Unknown status NCT03230058 Phase 2, Phase 3 Group 1 Natamycin 5% Suspension + voriconazole 1% eye drops; Group 2 Natamycin 5% Suspension + Vehicle eye drops
2 Use of Intracameral Moxifloxacin for the Prevention of Acute Endophthalmitis Following Cataract Surgery: a Controlled and Randomized Clinical Trial Terminated NCT02770729 Phase 3 Moxifloxacin;No injection of moxifloxacin
3 A Clinical Trial of Povidone-Iodine for the Treatment of Bacterial Corneal Ulcers Completed NCT00386958 Phase 2 Povidone-Iodine
4 EyeKon Medical, Inc. Capsular Tension Ring Clinical Study Unknown status NCT02332369
5 Early Vs Late Post Traumatic Cataract Surgery and Intraocular Lens Implantation Completed NCT02900365

Search NIH Clinical Center for Hypopyon

Genetic Tests for Hypopyon

Anatomical Context for Hypopyon

MalaCards organs/tissues related to Hypopyon:

40
Eye, Myeloid, Lung, Skin, Bone, Monocytes, B Cells

Publications for Hypopyon

Articles related to Hypopyon:

(show top 50) (show all 968)
# Title Authors PMID Year
1
Fungal keratitis: Pathogenesis, diagnosis and prevention. 61
31626916 2020
2
Intrastromal voriconazole: An adjuvant approach for recalcitrant mycotic keratitis. 61
31856462 2020
3
Vitreous infiltration with pink hypopyon in lung cancer. 61
31812291 2020
4
Intraocular infiltration of Philadelphia chromosome-positive acute lymphoblastic leukemia diagnosed by polymerase chain reaction from the aqueous humor: A case report. 61
31977890 2020
5
Factors Associated With Positive Microbial Culture in Patients With Endophthalmitis Based on Clinical Presentation and Multimodal Intraocular Sampling. 61
31972748 2020
6
Factors Associated With Positive Microbial Culture in Patients With Endophthalmitis Based on Clinical Presentation and Multimodal Intraocular Sampling. 61
31990738 2020
7
Endogenous Serratia marcescens panophthalmitis: A case series. 61
31508534 2019
8
Bristle Worm-Induced Keratouveitis: A Case Report. 61
31842040 2019
9
Management of infective corneal ulcers in a high-income developing country. 61
31860971 2019
10
Hypopyon sign in dermatoscopy of cutaneous angiosarcoma. 61
30982952 2019
11
Driving in Fog without Headlight: Management of a Challenging Case of Presumed Ocular Toxoplasmosis. 61
31577475 2019
12
Clinical analysis of microbiologically proven fungal keratitis according to prior topical steroid use: a retrospective study in South Korea. 61
31619199 2019
13
The Utility of Colistin in Multiple Drug-Resistant Pseudomonas aeruginosa Bacterial Keratitis in a Kaposi’s Sarcoma Patient 61
31486610 2019
14
Case Report: Corneal Ulceration from Bilateral Ectropion Due to Congenital Ichthyosis. 61
31479026 2019
15
Cluster endophthalmitis due to Stenotrophomonas maltophilia following intravitreal bevacizumab: outcomes of patients from North India. 61
30420442 2019
16
Aflibercept-Related Sterile Intraocular Inflammation Outcomes. 61
31153850 2019
17
A rare case of endophthalmitis after bleb needle revision for glaucoma Xen® gel stent. 61
31552771 2019
18
Neurological symptoms and mortality associated with Streptococcus gallolyticus subsp. pasteurianus in calves. 61
31500733 2019
19
Aspergillus Flavus Necrotising Scleritis following Pars Plana Vitrectomy. 61
31429609 2019
20
Pathobiology of Aspergillus Fumigatus Endophthalmitis in Immunocompetent and Immunocompromised Mice. 61
31466325 2019
21
CASE REPORT OF ABIOTROPHIA DEFECTIVA ENDOPHTHALMITIS AFTER REPEATED INJECTIONS OF DEXAMETHASONE INTRAVITREAL IMPLANT (OZURDEX). 61
31479011 2019
22
Phaco-antigenic glaucoma following uncomplicated cataract surgery. 61
31282196 2019
23
Endophthalmitis after dropless (Tri-Moxi injection) cataract surgery. 61
31155929 2019
24
Diagnostic dilemma of ocular lymphoma. 61
31175115 2019
25
Inverted Hypopyon. 61
31194236 2019
26
Natamycin niosomes as a promising ocular nanosized delivery system with ketorolac tromethamine for dual effects for treatment of candida rabbit keratitis; in vitro/in vivo and histopathological studies. 61
30744431 2019
27
RISK FACTORS, TREATMENT STRATEGIES, AND OUTCOMES OF ENDOPHTHALMITIS ASSOCIATED WITH SEVERE FUNGAL KERATITIS. 61
29474308 2019
28
Severe infectious keratitis in tropical environments: 118 cases collected over 10 years. 61
31379339 2019
29
Hypopyon pustules of Sneddon-Wilkenson disease. 61
30414189 2019
30
Contact Lens-Associated Microbial Keratitis in a Tertiary Eye Care Center in Turkey. 61
31045617 2019
31
Recalcitrant Paecilomyces keratitis. 61
31023737 2019
32
Etiological and Clinical Characteristics of HLA-B27-associated Uveitis in a Tertiary Referral Center 61
30829019 2019
33
Efficacy and Safety of Amphotericin B with Autologous Serum for Fungal Corneal Ulcer. 61
30700351 2019
34
Increased postoperative anterior chamber inflammation secondary to heat-resistant endotoxins. 61
30471849 2019
35
Diabetes Mellitus-Associated Uveitis: Clinical Features in a Chilean Series. 61
30811256 2019
36
Incidence, Risk Factors and Surgical Outcomes of Cataract among Patients with Uveitis in a University Referral Hospital in Riyadh, Saudi Arabia. 61
30142008 2019
37
Seasonal Hyperacute Panuveitis in Nepal: A Review over 40 Years of Surveillance. 61
29543556 2019
38
Prognostic Factors and Visual Outcomes of Pyogenic Liver Abscess-Related Endogenous Klebsiella pneumoniae Endophthalmitis: A 20-year retrospective review. 61
30705320 2019
39
Presumed Tuberculous Sclerokeratitis Presenting with Hypopyon. 61
30148654 2019
40
Behcet's Disease Presenting With Bilateral Hypopyon Masquerading Post Cataract Surgery Endophthalmitis. 61
31819669 2019
41
A cross-sectional study of sweat-induced dermatitis during a South Indian summer: a glimpse of sweat gland-mediated cutaneous inflammation. 61
29896898 2019
42
Clinical features of patients with diabetic anterior uveitis. 61
29563110 2019
43
Chronic annular pustular psoriasis resembling subcorneal pustular dermatosis: A case report. 61
31258906 2019
44
STENOTROPHOMONAS MALTOPHILIA ENDOPHTHALMITIS 1 MONTH AFTER INTRAVITREAL AFLIBERCEPT. 61
28358745 2019
45
The anti-inflammatory effect of minocycline on endotoxin-induced uveitis and retinal inflammation in rats. 61
31354229 2019
46
Long-term safety of posterior chamber implantable phakic contact lens for the correction of myopia. 61
30662257 2019
47
Understanding the Role of Pro-resolving Lipid Mediators in Infectious Keratitis. 61
31562617 2019
48
Outcomes of therapeutic keratoplasty for severe infectious keratitis in Chongqing, a 16-year experience. 61
31496763 2019
49
Acanthamoeba keratitis in Mexico: Report of a clinical case and importance of sensitivity assays for a better outcome. 61
30472333 2019
50
Successful treatment of Fusarium solani anterior chamber involvement secondary to contact lens associated corneal ulcer with intracameral Amphotericin B. 61
30828513 2019

Variations for Hypopyon

Expression for Hypopyon

Search GEO for disease gene expression data for Hypopyon.

Pathways for Hypopyon

GO Terms for Hypopyon

Cellular components related to Hypopyon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 VEGFA RBP3 IL6 IL1RN IL17A HLA-B

Biological processes related to Hypopyon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.58 VEGFA IL6 CD4
2 inflammatory response GO:0006954 9.55 TNFRSF1B IL6 IL1RN IL17A CRP
3 immune response GO:0006955 9.43 TNFRSF1B IL6 IL1RN IL17A HLA-B CD4
4 regulation of neuroinflammatory response GO:0150077 9.37 TNFRSF1B IL6
5 negative regulation of lipid storage GO:0010888 9.32 IL6 CRP
6 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.26 IL6 IL1RN
7 cytokine-mediated signaling pathway GO:0019221 9.1 VEGFA TNFRSF1B IL6 IL1RN IL17A CD4

Molecular functions related to Hypopyon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 VEGFA IL6 IL1RN IL17A

Sources for Hypopyon

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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