Aliases & Classifications for Hypopyon

MalaCards integrated aliases for Hypopyon:

Name: Hypopyon 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10443
ICD10 33 H20.05
ICD9CM 35 364.05
NCIt 50 C50593
SNOMED-CT 68 87807004
UMLS 73 C0020641

Summaries for Hypopyon

MalaCards based summary : Hypopyon is related to corneal dystrophy, band-shaped and hypopyon ulcer. An important gene associated with Hypopyon is MRAP (Melanocortin 2 Receptor Accessory Protein), and among its related pathways/superpathways are Glycerophospholipid biosynthesis and Adipogenesis. The drugs Dexamethasone and Ephedrine have been mentioned in the context of this disorder. Affiliated tissues include eye, myeloid and t cells, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 Hypopyon is a medical condition involving inflammatory cells in the anterior chamber of the... more...

Related Diseases for Hypopyon

Diseases related to Hypopyon via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 corneal dystrophy, band-shaped 29.4 EPHA5 MRAP
2 hypopyon ulcer 12.1
3 behcet syndrome 11.0
4 uveitis 10.4
5 leukemia 10.2
6 endophthalmitis 10.2
7 anterior uveitis 10.1
8 lymphoma 10.1
9 myeloid leukemia 10.0
10 iritis 10.0
11 corneal ulcer 10.0
12 leukemia, acute myeloid 9.9
13 leukemia, acute lymphoblastic 9.9
14 lymphoblastic leukemia 9.9
15 relapsing polychondritis 9.9
16 acquired immunodeficiency syndrome 9.9
17 iridocyclitis 9.9
18 panuveitis 9.9
19 retinitis 9.9
20 pneumonia 9.9
21 psoriasis 9.9
22 spondyloarthropathy 1 9.8
23 acute leukemia 9.8
24 arthritis 9.8
25 scleritis 9.8
26 acute closed-angle glaucoma 9.8
27 spondylitis 9.8
28 tuberculous uveitis 9.8
29 systemic lupus erythematosus 9.6
30 pemphigus vulgaris, familial 9.6
31 retinal detachment 9.6
32 lymphoma, hodgkin, classic 9.6
33 mycosis fungoides 9.6
34 astigmatism 9.6
35 lymphoma, non-hodgkin, familial 9.6
36 psoriatic arthritis 9.6
37 myocardial infarction 9.6
38 acute lymphocytic leukemia 9.6
39 acute myocardial infarction 9.6
40 b-cell lymphomas 9.6
41 cataract 9.6
42 crohn's disease 9.6
43 intraocular lymphoma 9.6
44 keratopathy 9.6
45 pemphigus foliaceus 9.6
46 pemphigus vulgaris 9.6
47 ulcerative colitis 9.6
48 colitis 9.6
49 epithelial basement membrane dystrophy 9.6
50 cysticercosis 9.6

Comorbidity relations with Hypopyon via Phenotypic Disease Network (PDN):


Acute Endophthalmitis Purulent Endophthalmitis

Graphical network of the top 20 diseases related to Hypopyon:



Diseases related to Hypopyon

Symptoms & Phenotypes for Hypopyon

GenomeRNAi Phenotypes related to Hypopyon according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.17 DHX9
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.17 EPHA5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.17 DHX9
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.17 EPHA5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.17 EPHA5
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.17 DHX9 EPHA5

Drugs & Therapeutics for Hypopyon

Drugs for Hypopyon (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
2
Ephedrine Approved Phase 4 299-42-3 9294
3
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
4 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
5
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
6
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
7
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
8
Polyestradiol phosphate Approved Phase 4 28014-46-2
9
Pseudoephedrine Approved Phase 4 90-82-4 7028
10 Anti-Bacterial Agents Phase 4,Phase 3
11 Antiemetics Phase 4,Phase 3
12 Anti-Infective Agents Phase 4,Phase 3
13 Anti-Inflammatory Agents Phase 4,Phase 3
14 Antineoplastic Agents, Hormonal Phase 4,Phase 3
15 Autonomic Agents Phase 4,Phase 3
16 BB 1101 Phase 4
17 Contraceptive Agents Phase 4
18 Contraceptives, Oral Phase 4
19 Contraceptives, Oral, Combined Phase 4
20 Dexamethasone acetate Phase 4 1177-87-3
21 Estradiol 17 beta-cypionate Phase 4
22 Estradiol 3-benzoate Phase 4
23 Fluoroquinolones Phase 4
24 Gastrointestinal Agents Phase 4,Phase 3
25 glucocorticoids Phase 4,Phase 3
26 HIV Protease Inhibitors Phase 4
27 Hormone Antagonists Phase 4,Phase 3
28 Hormones Phase 4,Phase 3
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
30 Nasal Decongestants Phase 4
31 Norgestimate, ethinyl estradiol drug combination Phase 4
32 Nucleic Acid Synthesis Inhibitors Phase 4
33 Ophthalmic Solutions Phase 4,Phase 3
34 Peripheral Nervous System Agents Phase 4,Phase 3
35 Pharmaceutical Solutions Phase 4,Phase 3
36
protease inhibitors Phase 4
37 Respiratory System Agents Phase 4
38 Tetrahydrozoline Phase 4
39 Topoisomerase Inhibitors Phase 4
40 Vasoconstrictor Agents Phase 4
41
Difluprednate Approved Phase 3 23674-86-4 443936
42
Fluprednisolone Approved Phase 3 53-34-9
43
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
44
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
45
Iodine Approved, Investigational Phase 3 7553-56-2 807
46
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
47
Natamycin Approved Phase 3 7681-93-8 5281099
48
Povidone Approved Phase 3 9003-39-8
49
Povidone-iodine Approved Phase 3 25655-41-8
50 Methylprednisolone acetate Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Efficacy and Safety of Vigadexa in Treating Inflammation and Infection Post-cataract Surgery Completed NCT00870103 Phase 4 Vigadexa (moxifloxacin 0.5% and dexamethasone 0.1%) eye drops
2 Aurolab Hydrophobic Foldable Intraocular Lens Study Completed NCT00449267 Phase 4
3 The Efficacy and Safety of IBI-10090 for the Treatment of Inflammation Associated With Cataract Surgery Completed NCT02006888 Phase 3 IBI-10090;Placebo
4 Difluprednate Pediatric Study for the Treatment of Inflammation Post-Cataract Surgery Completed NCT01124045 Phase 3 Difluprednate ophthalmic emulsion, 0.05%;Prednisolone acetate ophthalmic suspension, 1.0%
5 Safety and Efficacy of Difluprednate 0.05% for the Treatment of Anterior Uveitis Completed NCT01201798 Phase 3 Difluprednate 0.05% ophthalmic emulsion;Prednisolone acetate 1.0% ophthalmic suspension
6 A Clinical Trial of the Treatment of Fungal Corneal Ulcers With Povidone-Iodine Terminated NCT00516399 Phase 3 povidone-iodine 1.25% ophthalmic solution;natamycin ophthalmic suspension, USP 5%
7 Effect of Tetracaine on Pain Management and Corneal Healing in Patients With Acute Corneal Abrasion Withdrawn NCT02483897 Phase 3 Tetracaine 0.5% ophthalmic drops;Normal Saline placebo drops
8 Treatment of the Bilateral Severe Uveitis by IVT of Regulator T-cells: Study of Tolerance of Dose Suspended NCT02494492 Phase 1, Phase 2

Search NIH Clinical Center for Hypopyon

Genetic Tests for Hypopyon

Anatomical Context for Hypopyon

MalaCards organs/tissues related to Hypopyon:

41
Eye, Myeloid, T Cells, Testes, B Cells, Neutrophil

Publications for Hypopyon

Articles related to Hypopyon:

(show top 50) (show all 199)
# Title Authors Year
1
A rare case of superior hypopyon with iris neovascularization. ( 29563712 )
2018
2
Presumably contaminated intravenous infusion-induced <i>Aspergillus terreus</i> endogenous endophthalmitis presenting with posterior hypopyon. ( 29582833 )
2018
3
Inverse hypopyon (hyperoleon) at the posterior segment in pathological myopia. ( 29183904 )
2017
4
In response to: &amp;quot;Ranjan, P, Joshi P, and Gupta M. Staphylococcus aureus induced endogenous endophthalmitis with pink hypopyon.&amp;quot; ( 28448724 )
2017
5
Hemorrhagic hypopyon as presenting feature of intravascular lymphoma, a case report. ( 29070018 )
2017
6
Inverse Hypopyon. ( 28219502 )
2017
7
Bilateral Severe Sterile Inflammation with Hypopyon after Simultaneous Intravitreal Triamcinolone Acetonide and Aflibercept Injection in a Patient with Bilateral Marked Rubeosis Associated with Ocular Ischemic Syndrome. ( 28386497 )
2017
8
Tuberculous uveitis presenting as pigmented hypopyon - A case report. ( 29260068 )
2017
9
Primary adrenal T-cell lymphoma in a young adult presented with pseudo-hypopyon: a case report and literature review. ( 29043242 )
2017
10
Bilateral Hypopyon Uveitis in Chronic Myeloid Leukemia. ( 29344492 )
2017
11
Child with hypopyon. ( 29054898 )
2017
12
Hypopyon complicating the course of anterior uveitis in a patient with Behcet's syndrome. ( 27648274 )
2016
13
Ochrobactrum anthropi Keratitis with Focal Descemet's Membrane Detachment and Intracorneal Hypopyon. ( 27777806 )
2016
14
IMAGES IN CLINICAL MEDICINE. Hypopyon and Klebsiella Sepsis. ( 27355556 )
2016
15
Staphylococcus aureus Induced Endogenous Endophthalmitis with Pink Hypopyon. ( 27937098 )
2016
16
Hypopyon uveitis following panretinal photocoagulation. ( 27381997 )
2016
17
Inverted hypopyon in the eye. ( 26887888 )
2016
18
Treatment of Epithelial Downgrowth Masquerading as Unilateral Hypopyon Uveitis in a HLA-B27+ Individual. ( 27598054 )
2016
19
Unusual presentation of subretinal cysticercosis with hypopyon uveitis. ( 25871533 )
2015
20
Medical image. Leukaemic hypopyon. ( 25899495 )
2015
21
Pink hypopyon in a patient with Serratia marcescens corneal ulceration. ( 25861400 )
2015
22
Intraocular Relapse with Hypopyon and Retinal Infiltrates after Chemotherapy and Peripheral Blood Stem Cell Transplantation for Extranodal NK/T-Cell Lymphoma. ( 26763364 )
2015
23
Cytomegalovirus Uveitis with Hypopyon Mimicking Bacterial Endophthalmitis. ( 26078897 )
2015
24
Severe staphylococcal marginal keratitis presenting with hypopyon. ( 26286911 )
2015
25
Alternaria keratitis and hypopyon after clear-cornea phacoemulsification. ( 24461506 )
2014
26
When the eye gives it all: diagnosis of relapsing acute myeloblastic leukemia with anterior chamber tap of a chronic hypopyon. ( 25165787 )
2014
27
A case of panuveitis with hypopyon due to presumed ocular leishmaniasis in a HIV patient. ( 26530344 )
2014
28
Pigmented hypopyon in association with Listeria monocytogenes endopthalmitis: an interesting case report following refractive surgery procedure with literature review. ( 24669144 )
2014
29
Minimal trephination penetrating keratoplasty for severe fungal keratitis complicated with hypopyon. ( 24314417 )
2013
30
Hypopyon as the first sign of relapse in acute lymphoblastic leukaemia. ( 23400411 )
2013
31
Hypopyon and pseudoendophthalmitis 1 month after vitrectomy for retinal detachment with subretinal hemorrhage. ( 23676232 )
2013
32
'Hypopyon' in the anterior chamber: unilateral ocular relapse of acute myeloid leukaemia in a 2-year-old girl. ( 23750915 )
2013
33
Leukemic hypopyon in acute myeloid leukemia. ( 23225088 )
2013
34
Hypopyon uveitis-a rare presentation of intraocular tuberculosis. ( 23617801 )
2013
35
Inverted hypopyon in the posterior pole. ( 23538580 )
2013
36
Bilateral Hypopyon Uveitis Secondary to Mycosis Fungoides with Sezary Syndrome. ( 24131357 )
2013
37
Hypopyon Uveitis Following Panretinal Photocoagulation in a Diabetic Patient. ( 23947383 )
2013
38
Recurrent anterior uveitis with hypopyon revealing relapsing polychondritis. ( 23154727 )
2012
39
Hypopyon-like features: new dermoscopic criteria in the differential diagnosis of cutaneous lymphangioma circumscriptum and haemangiomas? ( 21645121 )
2012
40
Rifabutin-associated hypopyon uveitis and retinal vasculitis with a history of acute myeloid leukemia. ( 22311604 )
2012
41
Hypopyon in the context of tuberculous uveitis. ( 22229955 )
2012
42
Hypopyon in patients with fungal keratitis. ( 22490405 )
2012
43
A case of congenital corneal anesthesia with hypopyon in china. ( 22678876 )
2012
44
Hypopyon uveitis following LASIK in a patient with ulcerative colitis. ( 22869236 )
2012
45
Hypopyon uveitis in ankylosing spondylitis. ( 23013851 )
2012
46
Relapsing acute myeloid leukemia presenting as hypopyon uveitis. ( 21836350 )
2011
47
Anterior segment intraocular metallic foreign body causing chronic hypopyon uveitis. ( 21484173 )
2011
48
Hypopyon caused by septic embolisation from valvular endocarditis. ( 21134764 )
2011
49
Topiramate-induced bilateral anterior uveitis associated with hypopyon formation. ( 21034312 )
2011
50
Dark hypopyon in Streptococcus bovis endogenous endophthalmitis: clinicopathologic correlations. ( 21475652 )
2011

Variations for Hypopyon

Expression for Hypopyon

Search GEO for disease gene expression data for Hypopyon.

Pathways for Hypopyon

GO Terms for Hypopyon

Cellular components related to Hypopyon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.8 DHX9 EPHA5 LPIN1 LPIN2 MRAP NCAM1
2 endoplasmic reticulum GO:0005783 9.46 LPIN1 LPIN2 MRAP PITPNM1
3 cytoplasmic ribonucleoprotein granule GO:0036464 8.96 DHX9 PITPNM1
4 endoplasmic reticulum membrane GO:0005789 8.92 LPIN1 LPIN2 MRAP PITPNM1

Biological processes related to Hypopyon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.5 LPIN1 LPIN2 PITPNM1
2 phosphatidylcholine biosynthetic process GO:0006656 9.26 LPIN1 LPIN2
3 triglyceride biosynthetic process GO:0019432 9.16 LPIN1 LPIN2
4 phosphatidylethanolamine biosynthetic process GO:0006646 8.96 LPIN1 LPIN2
5 fatty acid catabolic process GO:0009062 8.62 LPIN1 LPIN2

Molecular functions related to Hypopyon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidate phosphatase activity GO:0008195 8.62 LPIN1 LPIN2

Sources for Hypopyon

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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