MCID: HYP084
MIFTS: 40

Hypopyon

Categories: Neuronal diseases
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Aliases & Classifications for Hypopyon

MalaCards integrated aliases for Hypopyon:

Name: Hypopyon 11 14 71 75

Classifications:



External Ids:

Disease Ontology 11 DOID:10443
ICD9CM 34 364.05
NCIt 49 C50593
SNOMED-CT 68 87807004
UMLS 71 C0020641

Summaries for Hypopyon

MalaCards based summary: Hypopyon is related to infectious anterior uveitis and endophthalmitis. An important gene associated with Hypopyon is RBP3 (Retinol Binding Protein 3), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include eye, myeloid and endothelial, and related phenotypes are growth/size/body region and no phenotypic analysis

Wikipedia: 75 Hypopyon is a medical condition involving inflammatory cells in the anterior chamber of the... more...

Related Diseases for Hypopyon

Diseases related to Hypopyon via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 954)
# Related Disease Score Top Affiliating Genes
1 infectious anterior uveitis 31.7 TNF IL17A
2 endophthalmitis 31.1 VEGFA TNF RBP3 IL6 IL1B CRP
3 keratopathy 30.4 VEGFA IL6 HEYL
4 macs syndrome 30.4 TNF IL10 CD4
5 corneal ulcer 30.3 VEGFA TNF IL6 IL1B HEYL
6 pars planitis 30.3 RBP3 HLA-B ACE
7 relapsing polychondritis 30.2 TNF IL6 CRP CD4
8 rubeosis iridis 30.2 VEGFA IL6
9 herpes zoster 30.2 IL10 HLA-B CD4
10 purulent endophthalmitis 30.2 VEGFA RBP3 CRP CD4
11 retinal detachment 30.1 VEGFA TNF IL6 IL10
12 sclerosing keratitis 30.1 RBP3 CRP
13 leukemia, acute monocytic 30.0 TNF IL6 IL1B
14 interstitial keratitis 30.0 TNF CRP
15 conjunctivitis 30.0 TNF IL6 IL10 HLA-B
16 haemophilus influenzae 30.0 TNF IL1B
17 pyomyositis 30.0 CRP CD4
18 monocytic leukemia 29.9 TNF IL6 IL1B
19 ocular tuberculosis 29.9 RBP3 CD4 ACE
20 keratitis, hereditary 29.8 VEGFA TNF IL6 IL1B IL17A IL10
21 aspergillosis 29.7 TNF IL6 IL1B IL10
22 arthropathy 29.7 TNF IL6 IL1B CRP
23 uveitis 29.7 VEGFA TNF RBP3 IL6 IL23R IL1B
24 leukemia, acute myeloid 29.6 VEGFA TNF IL6 IL1B IL10 CD4
25 pemphigus 29.6 TNF IL6 IL17A IL10
26 pemphigus foliaceus 29.6 IL6 IL1B IL10
27 acquired immunodeficiency syndrome 29.5 TNF IL6 IL1B IL10 HLA-B CRP
28 cytomegalovirus retinitis 29.5 TNF IL10 HLA-B CD4
29 sympathetic ophthalmia 29.5 TNF RBP3 IL17A IL10 CD4
30 macular retinal edema 29.4 VEGFA TNF IL6 IL1B ACE
31 juvenile rheumatoid arthritis 29.4 TNF IL6 IL1B CRP CD4
32 cataract 29.4 VEGFA TNF IL6 CRP ACE
33 macular dystrophy, dominant cystoid 29.4 VEGFA TNF RBP3 IL6 ACE
34 cysticercosis 29.4 IL6 IL1B IL10 CD4
35 dermatitis 29.4 TNF IL6 IL1B IL17A IL10
36 optic papillitis 29.4 TNF RBP3 CRP CD4 ACE
37 retinal vasculitis 29.4 VEGFA TNF RBP3 CD4 ACE
38 syphilis 29.3 TNF IL17A CRP CD4 ACE
39 osteomyelitis 29.3 TNF IL6 IL1B IL10 CRP
40 osteoarthritis 29.3 TNF IL6 IL1B IL17A CRP
41 rubella 29.3 TNF IL6 IL1B IL10 HLA-B
42 neuritis 29.3 VEGFA TNF IL6 IL1B IL10
43 neuroretinitis 29.3 VEGFA CRP CD4 ACE
44 orbital cellulitis 29.3 IL6 CRP CD4 ACE
45 immune deficiency disease 29.3 TNF IL6 IL1B IL17A IL10 HLA-B
46 listeriosis 29.2 TNF IL6 IL1B IL10 CD4
47 endocarditis 29.2 TNF IL6 IL17A IL10 CRP
48 reactive arthritis 29.2 TNF IL17A HLA-B ERAP1 CRP
49 vascular disease 29.2 VEGFA TNF IL6 CRP ACE
50 leishmaniasis 29.1 TNF IL6 IL1B IL17A IL10

Comorbidity relations with Hypopyon via Phenotypic Disease Network (PDN):


Acute Endophthalmitis Purulent Endophthalmitis

Graphical network of the top 20 diseases related to Hypopyon:



Diseases related to Hypopyon

Symptoms & Phenotypes for Hypopyon

MGI Mouse Phenotypes related to Hypopyon:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.1 ACE CD4 ERAP1 HEYL HLA-B IL10
2 no phenotypic analysis MP:0003012 10.06 CD4 ERAP1 HEYL HLA-B IL10 IL17A
3 neoplasm MP:0002006 9.98 ACE IL10 IL1B IL23R IL6 TNF
4 endocrine/exocrine gland MP:0005379 9.96 ACE CD4 ERAP1 HLA-B IL10 IL17A
5 liver/biliary system MP:0005370 9.91 ACE ERAP1 IL10 IL17A IL6 TNF
6 digestive/alimentary MP:0005381 9.76 CD4 HLA-B IL10 IL17A IL23R IL6
7 immune system MP:0005387 9.73 ACE CD4 CRP ERAP1 HLA-B IL10
8 hematopoietic system MP:0005397 9.36 ACE CD4 ERAP1 HLA-B IL10 IL17A

Drugs & Therapeutics for Hypopyon

Search Clinical Trials, NIH Clinical Center for Hypopyon

Genetic Tests for Hypopyon

Anatomical Context for Hypopyon

Organs/tissues related to Hypopyon:

MalaCards : Eye, Myeloid, Endothelial, Retina, Liver, Lung, Heart

Publications for Hypopyon

Articles related to Hypopyon:

(show top 50) (show all 1149)
# Title Authors PMID Year
1
Acute panuveitis after COVID-19 mRNA booster vaccination following cataract surgery. 62
36267387 2022
2
Moraxella nonliquefaciens superinfecting herpes simplex keratitis. 62
34015953 2022
3
Acremonium keratitis: Risk factors, clinical characteristics, management, and outcome in 65 cases. 62
36190039 2022
4
Nonsurgical Management of Severe Viral Keratitis with Hypopyon and Retrocorneal Plaques: A Case Series. 62
36269489 2022
5
Eye enucleation and exenteration in -cattle: a retrospective study of 38 cases (2013-2020). 62
36193779 2022
6
Cases of toxic anterior segment syndrome after primary pterygium surgery. 62
35567693 2022
7
Differential diagnosis of pseudohypopyon and discussion of Extranodal natural killer/T-cell lymphoma presenting as hypopyon panuveitis. 62
36203154 2022
8
Reply to: differential diagnosis of pseudohypopyon and discussion of extranodal natural killer/T-cell lymphoma presenting as hypopyon panuveitis. 62
36195840 2022
9
Subhyaloid hypopyon as a diagnostic cue in syphilitic necrotizing retinitis. 62
36131541 2022
10
Endophthalmitis: Epidemiology, Causing Agents, Therapy and Visual Outcome with Special Focus on Glaucoma Patients. 62
35803282 2022
11
Haemophilus Influenzae-Induced Corneal Ulcer and Endophthalmitis Triggered by Hair Dye. 62
35762600 2022
12
Fungal keratitis caused by Scedosporium apiospermum: a case report. 62
36068562 2022
13
Infectious keratitis caused by Klebsiella spp.: predisposing factors, presentation, and management. 62
36114910 2022
14
Fungal Keratitis: Clinical Features, Risk Factors, Treatment, and Outcomes. 62
36135687 2022
15
Risk factors and microbiological characteristics: from bacterial keratitis with hypopyon to keratitis-related endophthalmitis. 62
35441875 2022
16
Assessment of genotypes, endosymbionts and clinical characteristics of Acanthamoeba recovered from ocular infection. 62
36175838 2022
17
A 5-Year Retrospective Analysis of the Risk Factors, Treatment, and Prognosis of Patients With Fungal Keratitis in Heilongjiang, China. 62
35932821 2022
18
New onset of acute uveitis following COVID-19 vaccination. 62
35939122 2022
19
Management of an atypical case of post-operative endophthalmitis presenting as angle-closure glaucoma. 62
36007259 2022
20
Relapse of acute lymphoblastic leukemia presenting as masquerade uveitis with hypopyon in a child. 62
35791226 2022
21
Intraocular lymphoma masquerading as unilateral hypopyon anterior uveitis: a case report. 62
35900606 2022
22
Delayed-onset endophthalmitis associated with Achromobacter species developed in acute form several months after cataract surgery: Three case reports. 62
35979323 2022
23
Role of Immunotherapy in Pythium insidiosum Keratitis. 62
35895358 2022
24
Hypopyon after Periocular Corticosteroid Injection: A Case Series. 62
35852938 2022
25
Ophthalmic complications associated with methamphetamine use disorder. 62
35282603 2022
26
Microsporidial Endotheliitis Mimicking Graft Rejection After Deep Anterior Lamellar Keratoplasty. 62
34267060 2022
27
Anterior chamber tap cytology in acute postoperative endophthalmitis: a case-control study. 62
33574032 2022
28
Predictive Factors for Resolution of Dematiaceous Fungal Keratitis. 62
34369394 2022
29
Successful identification of Granulicatella adiacens in postoperative acute infectious endophthalmitis using a bacterial 16S ribosomal RNA gene-sequencing platform with MinION™: A case report. 62
35464681 2022
30
Cluster outbreak of Pseudomonas stutzeri acute endophthalmitis following phacoemulsification: A report of 14 cases from North India. 62
35647987 2022
31
[Unilateral recurrent elevation of intraocular pressure with hypopyon]. 62
34665314 2022
32
Acute Unilateral Hypopyon Uveitis and Secondary Glaucoma in an Adult With Relapsing Acute Lymphoblastic Leukemia. 62
35698696 2022
33
A case of endophthalmitis following needling procedure after PRESERFLO® Micro Shunt implantation. 62
34015943 2022
34
Clinical Investigation of the Safety and Efficacy of Low-temperature Plasma as an Adjuvant Treatment for Mild to Moderate Fungal Keratitis: A Pilot Study. 62
35522197 2022
35
Photo-activated chromophore for infectious keratitis cross-linking and its efficacy as a treatment modality in managing microbial keratitis. 62
35502028 2022
36
Panophthalmitis secondary to retained intraocular foreign body amidst a national lockdown during the COVID-19 pandemic: A case series and review of literature. 62
35638076 2022
37
Clinical Characteristics and Outcomes of Short-term Repeat Corneal Transplantation. 62
33555976 2022
38
The invasive Klebsiella pneumoniae syndrome: Case series. 62
35592799 2022
39
Pythium insidiosum keratitis - A review. 62
35325996 2022
40
Clinical profile and treatment outcomes of Fusarium keratitis. 62
35225530 2022
41
Recurrent Filamentous Fungal Keratitis Caused When the Primarily Selected Graft Diameter was Too Small. 62
35320860 2022
42
A rare case of infectious keratitis that developed 27-years after radial keratotomy. 62
34917857 2022
43
Postvitrectomy endophthalmitis caused by Morganella morganii: a case report and literature review. 62
35303817 2022
44
CASE REPORT OF ABIOTROPHIA DEFECTIVA ENDOPHTHALMITIS AFTER REPEATED INJECTIONS OF DEXAMETHASONE INTRAVITREAL IMPLANT (OZURDEX). 62
31479011 2022
45
Ophthalmologic manifestations as the initial presentation of chronic myeloid leukemia: A review. 62
34252423 2022
46
Voriconazole-impregnated multilayered AMT and intracorneal plus intracameral injection in recalcitrant fungal corneal ulcer. 62
35351742 2022
47
Hypopyon and White Cataract Due to an Intraocular Helminth. 62
35272562 2022
48
Toxic anterior segment syndrome following EyePCL implantation in a hyperopic patient. 62
35090761 2022
49
Fungal Endophthalmitis: Analysis of 730 Consecutive Eyes from 7 Tertiary Eye Care Centers in India. 62
34547530 2022
50
Successful Use of Intravitreal Bevacizumab and Methotrexate in a Case of Neovascularization of the Iris and Pseudohypopyon Secondary to Recurrent Diffuse Large B-Cell Lymphoma. 62
35371675 2022

Variations for Hypopyon

Expression for Hypopyon

Search GEO for disease gene expression data for Hypopyon.

Pathways for Hypopyon

Pathways related to Hypopyon according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 VEGFA TNF IL6 IL23R IL1B IL17A
2
Show member pathways
13.75 CD4 IL10 IL17A IL1B IL23R IL6
3
Show member pathways
13.56 CD4 IL10 IL17A IL1B IL23R IL6
4
Show member pathways
13.47 VEGFA TNF IL6 IL1B IL17A IL10
5
Show member pathways
13.35 TNF IL6 IL23R IL1B IL17A IL10
6
Show member pathways
13.25 TNF IL6 IL23R IL1B IL17A IL10
7
Show member pathways
13.24 VEGFA TNF IL6 IL23R IL1B IL17A
8
Show member pathways
12.6 HLA-B IL10 IL17A IL1B IL23R IL6
9 12.51 TNF IL1B IL17A IL10
10
Show member pathways
12.48 TNF IL6 IL23R IL1B IL17A IL10
11 12.17 VEGFA TNF IL6 IL1B IL10
12
Show member pathways
12.14 TNF IL23R IL17A IL10 CD4
13 12.08 TNF IL6 IL1B IL10
14 11.99 CD4 IL10 IL6 TNF
15 11.93 TNF IL6 IL1B
16 11.84 VEGFA IL6 IL10
17
Show member pathways
11.83 IL6 IL23R IL17A
18
Show member pathways
11.83 CD4 IL17A IL1B IL23R IL6
19 11.81 VEGFA TNF IL1B IL17A IL10 HLA-B
20 11.78 VEGFA TNF IL6 IL1B
21 11.75 CRP IL10 IL6 TNF
22
Show member pathways
11.74 IL6 CRP CD4
23 11.72 IL6 IL10 CD4
24 11.72 TNF IL6 IL1B IL10 CD4
25
Show member pathways
11.69 VEGFA TNF IL6 IL1B
26 11.68 TNF IL6 IL1B IL10
27 11.67 IL6 IL23R IL1B IL17A CD4
28
Show member pathways
11.65 TNF IL6 IL23R IL10
29 11.64 TNF IL6 IL1B
30 11.63 TNF IL6 IL10
31 11.54 TNF IL23R IL1B IL17A IL10 CD4
32 11.53 VEGFA TNF IL6 IL23R IL1B IL17A
33 11.51 TNF IL6 IL1B IL10
34 11.48 TNF IL6 IL1B
35 11.37 TNF IL6 IL1B IL10
36 11.3 TNF IL6 IL1B IL17A
37 11.29 TNF IL6 IL1B
38 11.18 CD4 IL10 IL1B IL6 TNF
39
Show member pathways
11.17 TNF IL6 IL23R IL1B IL17A IL10
40 11.12 IL6 IL1B IL10
41 11.1 VEGFA TNF IL6 IL1B IL17A
42 11.07 TNF IL6 CRP
43 10.97 TNF IL6 IL1B IL17A IL10
44 10.77 IL6 IL1B
45
Show member pathways
10.35 TNF IL6

GO Terms for Hypopyon

Cellular components related to Hypopyon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.96 VEGFA TNF RBP3 IL6 IL1B IL17A
2 extracellular space GO:0005615 9.62 VEGFA TNF RBP3 IL6 IL1B IL17A

Biological processes related to Hypopyon according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 10.33 CRP IL17A IL1B IL23R IL6 TNF
2 positive regulation of DNA-binding transcription factor activity GO:0051091 10.21 TNF IL6 IL1B IL10
3 cellular response to lipopolysaccharide GO:0071222 10.19 TNF IL6 IL1B IL10
4 positive regulation of MAPK cascade GO:0043410 10.19 VEGFA TNF IL6 CD4
5 positive regulation of interleukin-6 production GO:0032755 10.18 IL17A IL1B IL6 TNF
6 response to activity GO:0014823 10.11 IL10 IL6 TNF
7 regulation of insulin secretion GO:0050796 10.11 IL1B IL6 TNF
8 defense response to Gram-negative bacterium GO:0050829 10.1 CD4 IL17A IL23R IL6
9 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.09 IL10 IL6 TNF
10 liver regeneration GO:0097421 10.06 TNF IL6 IL10
11 immune response GO:0006955 10.06 TNF IL6 IL1B IL17A IL10 HLA-B
12 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.04 TNF IL6 IL17A
13 positive regulation of chemokine production GO:0032722 10.03 TNF IL6 IL1B
14 negative regulation of neurogenesis GO:0050768 10.03 TNF IL6 IL1B
15 response to lipopolysaccharide GO:0032496 10.01 ACE IL10 IL1B IL23R TNF
16 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 10 VEGFA TNF IL6 IL23R
17 positive regulation of osteoclast differentiation GO:0045672 9.99 TNF IL23R IL17A
18 positive regulation of glial cell proliferation GO:0060252 9.95 TNF IL6 IL1B
19 negative regulation of cytokine production involved in immune response GO:0002719 9.94 TNF IL10
20 positive regulation of fever generation GO:0031622 9.92 TNF IL1B
21 sequestering of triglyceride GO:0030730 9.92 TNF IL1B
22 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.91 TNF IL1B IL10
23 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.9 VEGFA ACE
24 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.89 TNF IL1B
25 negative regulation of gap junction assembly GO:1903597 9.84 IL1B ACE
26 chronic inflammatory response to antigenic stimulus GO:0002439 9.83 TNF IL10
27 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.77 HLA-B ERAP1 ACE
28 positive regulation of neuroinflammatory response GO:0150078 9.73 IL1B IL6 TNF
29 defense response to Gram-positive bacterium GO:0050830 9.65 TNF IL6 IL1B IL17A CRP
30 negative regulation of lipid storage GO:0010888 9.63 TNF IL6 CRP
31 vascular endothelial growth factor production GO:0010573 9.1 TNF IL6 IL1B

Molecular functions related to Hypopyon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.4 VEGFA TNF IL6 IL1B IL17A IL10
2 interleukin-6 receptor binding GO:0005138 9.26 IL6 ERAP1

Sources for Hypopyon

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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