Aliases & Classifications for Hypopyon

MalaCards integrated aliases for Hypopyon:

Name: Hypopyon 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10443
ICD9CM 34 364.05
NCIt 49 C50593
SNOMED-CT 67 87807004
ICD10 32 H20.05
UMLS 71 C0020641

Summaries for Hypopyon

MalaCards based summary : Hypopyon is related to pars planitis and ocular tuberculosis. An important gene associated with Hypopyon is MRAP (Melanocortin 2 Receptor Accessory Protein), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Human cytomegalovirus infection. The drugs Voriconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include eye, myeloid and endothelial, and related phenotypes are digestive/alimentary and immune system

Wikipedia : 74 Hypopyon is a medical condition involving inflammatory cells in the anterior chamber of the... more...

Related Diseases for Hypopyon

Diseases related to Hypopyon via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 685)
# Related Disease Score Top Affiliating Genes
1 pars planitis 30.7 RBP3 MRAP HLA-B
2 ocular tuberculosis 30.6 MRAP CD4
3 chronic endophthalmitis 30.4 RBP3 MRAP ASPRV1
4 idiopathic anterior uveitis 30.3 TNF IL6
5 neuroretinitis 30.3 MRAP CRP CD4
6 macular retinal edema 30.2 VEGFA TNF MRAP IL6
7 sympathetic ophthalmia 30.1 TNF RBP3 IL10
8 pyomyositis 30.0 CRP CD4
9 keratitis, hereditary 30.0 VEGFA TNF IL6 IL17A CD4
10 miliary tuberculosis 30.0 TNF CRP CD4
11 retinal detachment 29.9 VEGFA TNF IL6 IL10
12 septic arthritis 29.8 TNF MRAP IL6 CRP
13 endophthalmitis 29.8 VEGFA TNF MRAP IL6 CRP CD4
14 osteomyelitis 29.7 TNF IL6 IL10
15 scleritis 29.7 TNFRSF1B TNF MRAP CRP
16 end stage renal disease 29.7 VEGFA TNF IL6 CRP
17 juvenile arthritis 29.7 IL6 IL10 CRP
18 visceral leishmaniasis 29.6 TNF IL10 CRP
19 nervous system disease 29.6 VEGFA TNF IL6 CD4
20 tonsillitis 29.6 TNF IL6 IL10
21 relapsing polychondritis 29.6 IL6 IL17A IL10 CRP
22 pericarditis 29.6 TNF IL6 CRP CD4
23 arthropathy 29.5 TNF IL6 HLA-B CRP
24 cysticercosis 29.5 IL6 IL10 CD4
25 pemphigus 29.5 TNF IL6 IL10
26 pulmonary tuberculosis 29.4 TNF IL6 IL10 CRP
27 listeriosis 29.2 TNF IL6 IL10 CD4
28 retinal vasculitis 29.2 TNFRSF1B TNF RBP3 MRAP CD4
29 eales disease 29.2 VEGFA TNF RBP3 IL6 IL10
30 migraine with or without aura 1 29.2 TNF IL6 IL10 CRP
31 colitis 29.2 TNF IL6 IL17A IL10
32 dermatitis 29.2 TNF IL6 IL17A IL10
33 conjunctivitis 29.2 TNF IL6 IL10 HLA-B
34 immune deficiency disease 29.1 TNF IL6 IL10 HLA-B CD4
35 graft-versus-host disease 29.1 TNF IL6 IL10 HLA-B
36 pustulosis of palm and sole 29.1 TNFRSF1B TNF MRAP IL17A CRP
37 bronchitis 29.0 VEGFA TNF IL6 IL10 CRP
38 intermediate uveitis 28.9 TNF MRAP IL6 IL10 HLA-B
39 optic papillitis 28.9 TNFRSF1B RBP3 MRAP CRP CD4
40 uveitis 28.8 TNFRSF1B TNF RBP3 IL6 IL17A IL10
41 sarcoidosis 1 28.8 TNFRSF1B TNF MRAP CRP CD4
42 leishmaniasis 28.8 TNF IL6 IL17A IL10 CRP
43 ulcerative colitis 28.8 TNF IL6 IL17A IL10 CRP
44 leprosy 3 28.7 TNF IL6 IL17A IL10 CD4
45 spondyloarthropathy 28.6 TNF IL6 IL17A IL10 HLA-B
46 sezary's disease 28.6 TNFRSF1B IL10 CD4
47 spondyloarthropathy 1 28.5 TNFRSF1B TNF MRAP IL17A HLA-B CRP
48 vascular disease 28.5 VEGFA TNF IL6 IL10 CRP CD4
49 juvenile rheumatoid arthritis 28.5 TNFRSF1B TNF IL6 IL10 CRP
50 behcet syndrome 28.3 VEGFA UBAC2 TNFRSF1B TNF RBP3 MRAP

Comorbidity relations with Hypopyon via Phenotypic Disease Network (PDN):


Acute Endophthalmitis Purulent Endophthalmitis

Graphical network of the top 20 diseases related to Hypopyon:



Diseases related to Hypopyon

Symptoms & Phenotypes for Hypopyon

MGI Mouse Phenotypes related to Hypopyon:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.86 B4GALNT2 CD4 IL10 IL17A IL6 TNF
2 immune system MP:0005387 9.85 B4GALNT2 CD4 CRP IL10 IL17A IL6
3 integument MP:0010771 9.56 ASPRV1 CD4 IL10 IL17A IL6 TNF
4 respiratory system MP:0005388 9.17 IL10 IL17A IL6 MRAP TNF TNFRSF1B

Drugs & Therapeutics for Hypopyon

Drugs for Hypopyon (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Voriconazole Approved Phase 2, Phase 3 137234-62-9 71616
2
Clotrimazole Approved, Vet_approved Phase 2, Phase 3 23593-75-1 2812
3
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
4
Natamycin Approved Phase 2, Phase 3 7681-93-8 5281099
5
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
6
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
7
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
8
Polyestradiol phosphate Approved Phase 3 28014-46-2
9
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
10 Anti-Infective Agents, Local Phase 2, Phase 3
11 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
12 Hormone Antagonists Phase 2, Phase 3
13 Hormones Phase 2, Phase 3
14 Pharmaceutical Solutions Phase 2, Phase 3
15 Ophthalmic Solutions Phase 2, Phase 3
16 Antifungal Agents Phase 2, Phase 3
17 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3
18 Anti-Infective Agents Phase 3
19 Estradiol 17 beta-cypionate Phase 3
20 Contraceptive Agents Phase 3
21 Estradiol 3-benzoate Phase 3
22 Contraceptives, Oral, Combined Phase 3
23 Contraceptives, Oral Phase 3
24 Anti-Bacterial Agents Phase 3
25 Norgestimate, ethinyl estradiol drug combination Phase 3
26
Iodine Approved, Investigational Phase 2 7553-56-2 807
27
Povidone Approved Phase 2 9003-39-8
28
Povidone-iodine Approved Phase 2 25655-41-8
29 Plasma Substitutes Phase 2
30 Blood Substitutes Phase 2
31 cadexomer iodine Phase 2
32 Polymethyl Methacrylate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Combination Treatment of 5% Natamycin and 1% Voriconazole in Fungal Keratitis: a Prospective Randomized Double Masked Clinical Trial Unknown status NCT03230058 Phase 2, Phase 3 Group 1 Natamycin 5% Suspension + voriconazole 1% eye drops; Group 2 Natamycin 5% Suspension + Vehicle eye drops
2 Use of Intracameral Moxifloxacin for the Prevention of Acute Endophthalmitis Following Cataract Surgery: a Controlled and Randomized Clinical Trial Terminated NCT02770729 Phase 3 Moxifloxacin;No injection of moxifloxacin
3 A Clinical Trial of Povidone-Iodine for the Treatment of Bacterial Corneal Ulcers Completed NCT00386958 Phase 2 Povidone-Iodine
4 EyeKon Medical, Inc. Capsular Tension Ring Clinical Study Unknown status NCT02332369
5 Early Vs Late Post Traumatic Cataract Surgery and Intraocular Lens Implantation Completed NCT02900365

Search NIH Clinical Center for Hypopyon

Genetic Tests for Hypopyon

Anatomical Context for Hypopyon

MalaCards organs/tissues related to Hypopyon:

40
Eye, Myeloid, Endothelial, T Cells, B Cells, Retina, Liver

Publications for Hypopyon

Articles related to Hypopyon:

(show top 50) (show all 988)
# Title Authors PMID Year
1
Hypopyon following selective laser trabeculoplasty. 61
32322746 2020
2
Quantitative Ocular Ultrasound Findings in Microbial Keratitis-Associated Endophthalmitis. 61
32147489 2020
3
A case report of fulminant endophthalmitis caused by Streptococcus dysgalactiae in a patient with traumatic corneal laceration. 61
32552664 2020
4
Posterior hypopyon in fungal endogenous endophthalmitis secondary to presumably contaminated dextrose infusion. 61
32373756 2020
5
Endogenous Endophthalmitis successfully treated with Intravitreal Povidone-iodine injection: a case report. 61
32503467 2020
6
Diabetes Mellitus-Associated Uveitis: Clinical Features in a Chilean Series. 61
30811256 2020
7
Lenticular fungal infection caused by Aspergillus in a patient with traumatic corneal laceration: a case report. 61
32357853 2020
8
Clinical features, management and outcomes of patients with sterile endophthalmitis associated with intravitreal injection of antivascular endothelial growth factor. 61
32156487 2020
9
Tuberculous corneal ulcer with hypopyon: A case report. 61
32317491 2020
10
Bristle Worm-Induced Keratouveitis: A Case Report. 61
31842040 2020
11
A Case Report of Sweet's Syndrome with Panuveitis and Rhegmatogenous Retinal Detachment. 61
32394773 2020
12
Acanthamoeba Keratitis Versus Mixed Acanthamoeba and Bacterial Keratitis: Comparison of Clinical and Microbiological Profiles. 61
32452992 2020
13
[A clinical analysis of 1 414 cases of fungal keratitis]. 61
32306621 2020
14
Niosomes: Do They Increase the Potency of Topical Natamycin Ketorolac Formula in Treating Aspergillus Keratitis? An Experimental Study. 61
32357092 2020
15
Open-source automatic segmentation of ocular structures and biomarkers of microbial keratitis on slit-lamp photography images using deep learning. 61
32248131 2020
16
Contact Lens-Associated Microbial Keratitis in a Tertiary Eye Care Center in Turkey. 61
31045617 2020
17
Rabbit Fungal Keratitis Model of Fusarium solani Tested Against Three Commercially Available Antifungal Drugs. 61
32134799 2020
18
Clinical Features and Outcomes of Kocuria Keratitis and Comparison With Coagulase-Negative Staphylococci Keratitis. 61
32243425 2020
19
An unusual vertical hypopyon. 61
32095657 2020
20
[Endophthalmitis after perforation of the conjunctiva by a glaucoma gel-stent implant]. 61
32112220 2020
21
Rifabutin-Cobicistat Drug Interaction Resulting in Severe Bilateral Panuveitis. 61
32399018 2020
22
Vitreous infiltration with pink hypopyon in lung cancer. 61
31812291 2020
23
Intraocular infiltration of Philadelphia chromosome-positive acute lymphoblastic leukemia diagnosed by polymerase chain reaction from the aqueous humor: A case report. 61
31977890 2020
24
Intrastromal voriconazole: An adjuvant approach for recalcitrant mycotic keratitis. 61
31856462 2020
25
Fungal keratitis: Pathogenesis, diagnosis and prevention. 61
31626916 2020
26
Herpes zoster keratouveitis with hypopyon and hyphema. 61
32309125 2020
27
Factors Associated With Positive Microbial Culture in Patients With Endophthalmitis Based on Clinical Presentation and Multimodal Intraocular Sampling. 61
31972748 2020
28
NOVEL CASE OF CLOSTRIDIUM PERFRINGENS ENDOPHTHALMITIS AFTER ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR INJECTION. 61
29176524 2020
29
Factors Associated With Positive Microbial Culture in Patients With Endophthalmitis Based on Clinical Presentation and Multimodal Intraocular Sampling. 61
31990738 2020
30
Intrastromal injection of voriconazole as a therapeutic of fungal hypopyon: a case report. 61
32537057 2020
31
Endogenous Serratia marcescens panophthalmitis: A case series. 61
31508534 2019
32
Management of infective corneal ulcers in a high-income developing country. 61
31860971 2019
33
Hypopyon sign in dermatoscopy of cutaneous angiosarcoma. 61
30982952 2019
34
Driving in Fog without Headlight: Management of a Challenging Case of Presumed Ocular Toxoplasmosis. 61
31577475 2019
35
Clinical analysis of microbiologically proven fungal keratitis according to prior topical steroid use: a retrospective study in South Korea. 61
31619199 2019
36
The Utility of Colistin in Multiple Drug-Resistant Pseudomonas aeruginosa Bacterial Keratitis in a Kaposi’s Sarcoma Patient 61
31486610 2019
37
Case Report: Corneal Ulceration from Bilateral Ectropion Due to Congenital Ichthyosis. 61
31479026 2019
38
Cluster endophthalmitis due to Stenotrophomonas maltophilia following intravitreal bevacizumab: outcomes of patients from North India. 61
30420442 2019
39
Aflibercept-Related Sterile Intraocular Inflammation Outcomes. 61
31153850 2019
40
A rare case of endophthalmitis after bleb needle revision for glaucoma Xen® gel stent. 61
31552771 2019
41
Neurological symptoms and mortality associated with Streptococcus gallolyticus subsp. pasteurianus in calves. 61
31500733 2019
42
Aspergillus Flavus Necrotising Scleritis following Pars Plana Vitrectomy. 61
31429609 2019
43
Pathobiology of Aspergillus Fumigatus Endophthalmitis in Immunocompetent and Immunocompromised Mice. 61
31466325 2019
44
CASE REPORT OF ABIOTROPHIA DEFECTIVA ENDOPHTHALMITIS AFTER REPEATED INJECTIONS OF DEXAMETHASONE INTRAVITREAL IMPLANT (OZURDEX). 61
31479011 2019
45
Phaco-antigenic glaucoma following uncomplicated cataract surgery. 61
31282196 2019
46
Diagnostic dilemma of ocular lymphoma. 61
31175115 2019
47
Inverted Hypopyon. 61
31194236 2019
48
Endophthalmitis after dropless (Tri-Moxi injection) cataract surgery. 61
31155929 2019
49
Natamycin niosomes as a promising ocular nanosized delivery system with ketorolac tromethamine for dual effects for treatment of candida rabbit keratitis; in vitro/in vivo and histopathological studies. 61
30744431 2019
50
RISK FACTORS, TREATMENT STRATEGIES, AND OUTCOMES OF ENDOPHTHALMITIS ASSOCIATED WITH SEVERE FUNGAL KERATITIS. 61
29474308 2019

Variations for Hypopyon

Expression for Hypopyon

Search GEO for disease gene expression data for Hypopyon.

Pathways for Hypopyon

Pathways related to Hypopyon according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.19 VEGFA TNFRSF1B TNF IL6 IL17A IL10
2
Show member pathways
12.82 VEGFA TNFRSF1B TNF IL6 HLA-B CD4
3
Show member pathways
12.54 VEGFA TNF IL6 IL17A IL10 HLA-B
4
Show member pathways
12.53 TNF IL6 IL17A IL10 CD4
5
Show member pathways
12.52 TNF IL6 IL17A IL10 CD4
6
Show member pathways
12.5 TNF IL6 IL17A IL10 CD4
7 12.26 TNF IL6 HLA-B CD4
8
Show member pathways
12.25 TNFRSF1B TNF IL6 IL10
9
Show member pathways
12.18 TNF IL6 IL17A IL10 HLA-B
10 12.11 VEGFA TNF IL6 IL10
11 11.86 TNF IL6 IL10 CD4
12 11.83 TNF IL6 IL10
13 11.82 VEGFA TNF IL6
14 11.81 TNF IL6 CD4
15
Show member pathways
11.77 IL6 IL17A CD4
16 11.73 VEGFA TNF IL6 IL17A
17 11.68 TNF IL6 IL10
18 11.61 TNF IL17A IL10 CD4
19
Show member pathways
11.59 VEGFA TNF IL6
20
Show member pathways
11.58 TNF IL6 IL17A IL10 CD4
21 11.54 TNF IL6 IL10 CD4
22 11.48 TNF IL6 IL10
23 11.31 TNFRSF1B TNF IL6 IL10
24 11.3 TNF IL6 IL10
25
Show member pathways
11.27 TNFRSF1B TNF IL10
26 11.24 TNF IL6 IL10
27 11.19 TNF IL6 IL17A
28 11.16 VEGFA TNFRSF1B TNF IL6 IL17A IL10
29 10.89 TNF IL6 CRP
30 10.72 TNF IL6 IL10 CD4

GO Terms for Hypopyon

Biological processes related to Hypopyon according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.8 TNFRSF1B TNF IL6 IL17A CRP
2 cellular response to lipopolysaccharide GO:0071222 9.76 TNFRSF1B TNF IL6 IL10
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.75 VEGFA IL6 CD4
4 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.73 VEGFA TNF IL6
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.7 VEGFA TNF IL6
6 response to glucocorticoid GO:0051384 9.67 TNF IL6 IL10
7 positive regulation of neuroinflammatory response GO:0150078 9.57 TNF IL6
8 regulation of neuroinflammatory response GO:0150077 9.55 TNFRSF1B IL6
9 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.54 TNF IL17A
10 endothelial cell apoptotic process GO:0072577 9.51 TNF IL10
11 positive regulation of JAK-STAT cascade GO:0046427 9.5 TNF IL6 IL10
12 immune response GO:0006955 9.5 TNFRSF1B TNF IL6 IL17A IL10 HLA-B
13 negative regulation of cytokine production involved in immune response GO:0002719 9.48 TNF IL10
14 negative regulation of cytokine secretion involved in immune response GO:0002740 9.43 TNF IL10
15 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.43 TNF IL6 IL17A
16 receptor biosynthetic process GO:0032800 9.37 TNF IL10
17 negative regulation of lipid storage GO:0010888 9.33 TNF IL6 CRP
18 cytokine-mediated signaling pathway GO:0019221 9.17 VEGFA TNFRSF1B TNF IL6 IL17A IL10

Molecular functions related to Hypopyon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 VEGFA TNF IL6 IL17A IL10

Sources for Hypopyon

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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