Hypothalamic Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Hypothalamic Disease, also known as hypothalamic diseases, is related to precocious puberty and diabetes insipidus, neurohypophyseal. An important gene associated with Hypothalamic Disease is PRL (Prolactin), and among its related pathways/superpathways are TGF-Beta Pathway and GPCR downstream signalling. The drugs Exenatide and Oxytocin have been mentioned in the context of this disorder. Affiliated tissues include hypothalamus, pituitary and testes, and related phenotypes are nervous system and homeostasis/metabolism

Wikipedia: ⁷⁵ Hypothalamic disease is a disorder presenting primarily in the hypothalamus, which may be caused by... more...

Sources

Related Diseases for Hypothalamic Disease

Diseases related to Hypothalamic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 387)

#	Related Disease	Score	Top Affiliating Genes
1	precocious puberty	30.5	GNRH1 GH1
2	diabetes insipidus, neurohypophyseal	30.3	POMC AVP
3	premature ovarian failure 7	30.1	POMC GH1 CRH
4	hypothyroidism, congenital, nongoitrous, 1	30.0	TSHB GHRH
5	diabetes insipidus	29.7	PRL POMC INS GH1 CRH AVP
6	neurotic disorder	29.7	POMC INS CRH
7	galactorrhea	29.7	PRL IGF1
8	inappropriate adh syndrome	29.5	PRL POMC CRH AVP
9	pituitary tumors	29.4	PRL IGF1 GH1
10	hypogonadism	29.3	PRL POMC INS IGF1 GNRH1 GH1
11	panic disorder	29.3	TRH PRL POMC GHRH CRH
12	sleep apnea	29.2	INS IGF1 HCRT
13	prediabetes syndrome	29.2	INS IGF1 GH1
14	central diabetes insipidus	29.2	TRH PRL POMC IGF1 GNRH1 GH1
15	overnutrition	29.1	POMC INS IGF1
16	hypogonadotropic hypogonadism	29.1	PRL POMC INS IGF1 GNRH1
17	pituitary-dependent cushing's disease	29.1	TRH PRL POMC GHRH GH1 CRH
18	apnea, obstructive sleep	29.0	POMC INS IGF1 HCRT
19	amenorrhea	28.9	TRH PRL POMC INS IGF1 GNRH1
20	mccune-albright syndrome	28.9	PRL POMC IGF1 GHRH GH1
21	anovulation	28.9	PRL INS IGF1 GNRH1 CRH
22	craniopharyngioma	28.9	TRH PRL INS IGF1 GNRH1 GH1
23	polycystic ovary syndrome	28.8	PRL POMC INS IGF1 GNRH1 GH1
24	ovarian disease	28.8	PRL POMC INS IGF1 GNRH1
25	insulin-like growth factor i	28.8	PRL INS IGF1 GHRH GH1
26	hyperandrogenism	28.6	PRL POMC INS IGF1 GNRH1 GH1
27	leptin deficiency or dysfunction	28.5	TRH POMC INS IGF1 HCRT GNRH1
28	sleep disorder	28.5	POMC INS IGF1 HCRT CRH
29	major depressive disorder	28.4	TRH PRL POMC INS HCRT CRH
30	anorexia nervosa	28.4	PRL POMC INS IGF1 HCRT GHRH
31	empty sella syndrome	28.3	TRH PRL POMC INS IGF1 GNRH1
32	hypopituitarism	28.3	TRH PRL POMC INS IGF1 GNRH1
33	hypothyroidism	28.2	TSHB TRH PRL POMC INS IGF1
34	hypoglycemia	28.2	TRH PRL POMC INS IGF1 GHRH
35	adenoma	28.0	TSHB TRH PRL POMC IGF1 GHRH
36	hyperprolactinemia	27.9	TRH PRL POMC INS IGF1 GNRH1
37	pituitary hormone deficiency, combined, 2	27.8	TSHB TRH PRL POMC IGF1 GNRH1
38	pituitary adenoma	27.7	TSHB TRH PRL POMC IGF1 GNRH1
39	acromegaly	27.7	TRH PRL POMC INS IGF1 GNRH1
40	pituitary gland disease	27.7	TSHB TRH PRL POMC INS IGF1
41	conn's syndrome	27.5	TRH PRL POMC INS IGF1 GNRH1
42	prader-willi syndrome	27.4	TRH PRL POMC INS IGF1 HCRT
43	body mass index quantitative trait locus 11	27.2	TRH PRL POMC INS IGF1 HCRT
44	rohhad	11.6
45	rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome	11.6
46	fryns microphthalmia syndrome	11.1
47	froelich syndrome	10.9
48	leydig cell hypoplasia type ii	10.3	PRL GNRH1
49	pyometritis	10.3	PRL GNRH1
50	chiasmal syndrome	10.3	PRL POMC

Graphical network of the top 20 diseases related to Hypothalamic Disease:

Sources

Symptoms & Phenotypes for Hypothalamic Disease

MGI Mouse Phenotypes related to Hypothalamic Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	10.2	AVP CRH GH1 GHRH GNRH1 HCRT
2	homeostasis/metabolism	MP:0005376	10.06	AVP CRH GH1 GHRH GNRH1 HCRT
3	renal/urinary system	MP:0005367	10.03	AVP CRH GH1 GNRH1 IGF1 INS
4	growth/size/body region	MP:0005378	9.96	CRH GH1 GHRH GNRH1 HCRT IGF1
5	liver/biliary system	MP:0005370	9.95	CRH GH1 GHRH GNRH1 INS POMC
6	adipose tissue	MP:0005375	9.85	CRH GH1 GHRH IGF1 INS POMC
7	endocrine/exocrine gland	MP:0005379	9.81	CRH GH1 GHRH GNRH1 IGF1 INS
8	behavior/neurological	MP:0005386	9.61	AVP CRH GH1 GHRH HCRT INS
9	immune system	MP:0005387	9.28	AVP CRH GH1 GHRH GNRH1 IGF1

Sources

Drugs & Therapeutics for Hypothalamic Disease

Drugs for Hypothalamic Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Exenatide

Approved, Investigational

Phase 4

141758-74-9

45588096

2

Oxytocin

Approved, Vet_approved

Phase 4

50-56-6

439302 53477758

3

Hydrocortisone succinate

Approved

Phase 4

2203-97-6

3643

4

Hydrocortisone acetate

Approved, Vet_approved

Phase 4

50-03-3

5

Hydrocortisone

Approved, Vet_approved

Phase 4

50-23-7

3640 5754

Synonyms:

(11ALPHA,14BETA)-11,17,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE

(11b)-11,17,21-Trihydroxypregn-4-ene-3,20-dione

(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione

(11Β)-11,17,21-trihydroxypregn-4-ene-3,20-dione

(1S,2R,10S,11S,14S,15S,17S)-14,17-DIHYDROXY-14-(2-HYDROXYACETYL)-2,15-DIMETHYLTETRACYCLO[8.7.0.0^{2,7}.0^{11,15}]HEPTADEC-6-EN-5-ONE

11 Epicortisol

11a-Hydroxycorticosterone

11alpha-Hydroxycorticosterone

11b,17,21-Trihydroxyprogesterone

11b,17a,21-Trihydroxy-4-pregnene-3,20-dione

11beta,17,21-Trihydroxyprogesterone

11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione

11beta-Hydrocortisone

11-beta-Hydrocortisone

11beta-Hydroxycortisone

11-beta-Hydroxycortisone

11b-Hydrocortisone

11b-Hydroxycortisone

11-Epicortisol

11-Hydrocortisone

11Β,17α,21-trihydroxy-4-pregnene-3,20-dione

11Β-hydrocortisone

17a-Hydroxycorticosterone

17alpha-Hydroxycorticosterone

17-Hydroxycorticosterone

4-Pregnen-11b,17a,21-triol-3,20-dione

4-Pregnen-11beta,17alpha,21-triol-3,20-dione

4-Pregnen-11β,17α,21-triol-3,20-dione

4-Pregnene-11alpha,21-triol 3,20-dione

4-Pregnene-11b,17a,21-triol-3,20-dione

ACETASOL HC

ACTICO МИХАИЛRT

Acticort

Acticort®|Efmody®|Plenadren®

Aeroseb HC

Aeroseb-HC

Alacort

Ala-cort

Ala-scalp

Algicirtis

Alphaderm

Amberin

Anflam

Anti-inflammatory hormone

Anucort-HC

ANUGESIC HC

Anusol HC

ANUSOL PLUS HC

ANUSOL SOOTHING RELIEF

Anusol-HC

Aquacort

Aquanil HC

Balneol-HC

Barseb HC

Basan-corti

Beta-HC

b-HC

CaldeCORT spray

CALMURID HC

CANESTEN HC

Cetacort

Chronocort

CIPRO HC

Clear aid

Cleiton

Cobadex

Colocort

Compound F

CORLAN

Cor-oticin

Cortanal

Cor-tar-quin

Cort-dome

Cortef

CORTENEM

Cortenema

Cortesal

Corticreme

Cortifair

Cortifan

Cortifoam

Cortiment

Cortisol

Cortisol alcohol

Cortisolonum

Cortisporin

Cortisporin otico

Cortispray

Cortizol

Cortolotion

Cortonema

Cortoxide

Cort-quin

CORTRIL

Cremesone

Cremicort-H

Cutisol

DAKTACORT

DAKTACORT HYDROCORT

Delacort

DERMA CARE HYDROCORT

Dermacort

Derm-aid

DERMASPRAY DEMANG

Dermil

Dermolate

Dihydrocostisone

Dioderm

Dome-cort

Domolene-HC

Drotic

ECONACORT

Ef corlin

Efcorbin

Efcortelan

EFCORTELAN P

Efcortelin

Eldecort

Eldercort

Epicort

Epicortisol

Epiderm H

Esiderm H

EURAX-HC

EURAX-HYDROCORT

Evacort

EXE-CORT

Ficortril

Fiocortril

Flexicort

Foille insetti

Genacort

GERMOLOIDS HC

Glycort

GREGODERM

gyno-Cortisone

HC

HC #1

HC #4

HC (HYDROCORTISONE)

HC45

H-Cort

Heb cort

Heb-cort

Hi-cor

Hidalone

hidro-Colisona

Hidrocortisona

Hycort

Hycortol

Hycortole

Hydracort

Hydrasson

hydro-Adreson

hydro-Colisona

Hydrocort

HYDROCORT IN CALAMINE OILY

HYDROCORT IN CETOMACROGOL FOR A

HYDROCORT IN WTE SOFT PARAF

Hydrocortal

Hydrocorticosterone

Hydrocortisone

Hydrocortisone acetate

Hydrocortisone alcohol

Hydrocortisone base

Hydrocortisone butyrate

Hydrocortisone free alcohol

Hydrocortisone in absorbase

Hydrocortisone sodium phosphate

Hydrocortisone valerate

Hydrocortisone, (11 alpha)-isomer

Hydrocortisone, (9 beta,10 alpha,11 alpha)-isomer

Hydrocortisonum

Hydrocortistab

Hydrocortisyl

HYDROCORTONE

HYDRODERM

HYDRODERM HC

hydro-RX

Hydroskin

Hydroxycortisone

Hysone

Hytisone

Hytone

Hytone lotion

Idrocortisone

Incortin-H

Incortin-hydrogen

JUNGLE FOR

Kendall's compound F

Komed HC

Kyypakkaus

Lacticare HC

Lacticare-HC

Lactisona

Locoid

Lubricort

Maintasone

Medicort

Meusicort

Micort-HC

Mildison

MILDISON LIPOCREAM

Milliderm

neo-Cort-dome

neo-Cortef

Neosporin-H ear

Nogenic HC

NSC-10483

Nutracort

NYBADEX

Nystaform-HC

Ophthocort

Optef

Otalgine

Otic-neo-cort-dome

Otobiotic

Otocort

OTOSEPTIL

Otosone-F

OTOSPORIN

Pediotic suspension

Penecort

PERINAL

Permicort

Plenadren

Polcort H

Preparation H hydrocortisone cream

Prepcort

Prestwick_265

Prevex HC

Proctocort

PROCTOCREAM HC

Proctofoam

PROCTOFOAM HC

PROCTOSEDYL

Protocort

QUINOCORT

Racet

Rectoid

Reichstein's substance m

Remederm HC

Sanatison

Scalpicin capilar

Schericur

Scheroson F

SENTIAL HC

Sigmacort

Signef

Stie-cort

Stiefcorcil

Synacort

Systral hydrocort

Tarcortin

Terra-cortril

TERRA-CORTRIL NYSTATIN

Texacort

Timocort

TIMODINE

Topicort

TOPISONE

Transderma H

Traumaide

TRI-CICATRIN

U-cort

Uniderm

UNIROID

UNIROID HC

Vioform-hydrocortisone

VoSol HC

Vytone

XYLOPROCT

Zenoxone

β-HC

6

Arginine Vasopressin

Phase 4

7

Hormones

Phase 4

8

Hormone Antagonists

Phase 4

9

Hypoglycemic Agents

Phase 4

10

Glucagon-Like Peptide 1

Phase 4

11

Incretins

Phase 4

12

Anti-Obesity Agents

Phase 4

13

Corticotropin-Releasing Hormone

Phase 4

14

Hydrocortisone 17-butyrate 21-propionate

Phase 4

15

Estradiol

Approved, Investigational, Vet_approved

50-28-2

5757

Synonyms:

(+)-3,17B-ESTRADIOL

(17b)-Estra-1,3,5(10)-triene-3,17-diol

(17BETA)-ESTRA-1,3,5(10)-TRIENE-3,17-DIOL

(17Β)-ESTRA-1,3,5(10)-TRIENE-3,17-DIOL

(1S,10R,11S,14S,15S)-15-METHYLTETRACYCLO[8.7.0.0^{2,7}.0^{11,15}]HEPTADECA-2,4,6-TRIENE-5,14-DIOL

(8R,9S,13S,14S,17S)-13-METHYL-6,7,8,9,11,12,14,15,16,17-DECAHYDROCYCLOPENTA[A]PHENANTHRENE-3,17-DIOL

[3H]-estradiol|[3H]-estrogen|[3H]E2|[3H]estradiol

13B-METHYL-1,3,5(10)-GONATRIENE-3,17B-OL

17 beta Estradiol

17 beta Oestradiol

17 beta-Estradiol

17 beta-Oestradiol

17b Oestradiol

17b-Estra-1,3,5(10)-triene-3,17-diol

17B-ESTRADIOL

17BETA OESTRADIOL

17BETA-ESTRA-1,3,5(10)-TRIENE-3,17-DIOL

17BETA-ESTRADIOL

17BETA-OESTRADIOL

17B-OESTRADIOL

17Β oestradiol

17Β-ESTRA-1,3,5(10)-TRIENE-3,17-DIOL

17β-estradiol

17Β-OESTRADIOL

3,17B-DIHYDROXYESTRA-1,3,5(10)-TRIENE

3,17B-ESTRADIOL

3,17-EPIDIHYDROXYESTRATRIENE

ADGYN ESTRO

AERODIOL

AGOFOLLIN

ALFATRADIOL

ALORA

ALTRAD

AMNESTROGEN

AQUADIOL

AQUAGEN

BARDIOL

BEDOL

B-ESTRADIOL

BETA-ESTRADIOL

CIS-ESTRADIOL

CLIMADERM

CLIMARA

CLIMARA PRO

COMPUDOSE

CORPAGEN

Delestrogen

DELTA-ESTRADIOL

DELTA-OESTRADIOL

DEPO-ESTRADIOL

DERMESTRIL

DERMESTRIL 100

DERMESTRIL 25

DERMESTRIL 50

DERMESTRIL SEPTEM 25

DERMESTRIL SEPTEM 50

DERMESTRIL SEPTEM 75

DESTRADIOL

D-ESTRADIOL

DIHYDROFOLLICULAR HORMONE

DIHYDROFOLLICULIN

DIHYDROMENFORMON

DIHYDROTHEELIN

DIHYDRO-THEELIN

DIHYDROXYESTRIN

DIMENFORMON

DIOGYN

DIOGYNETS

DIVIGEL

D-OESTRADIOL

E2

E2|estrogen|oestrodiol|oestrogen

E-CYPIONATE

ELESTRIM

ELESTRIN

ELLESTE SOLO

ELLESTE SOLO MX 40

ELLESTE SOLO MX 80

ENCORE

EPIESTRIOL 50

ESCLIM

ESTRA-1,3,5(10)-TRIENE-3,17B-DIOL

ESTRACE

ESTRADERM

ESTRADERM MX 100

ESTRADERM MX 25

ESTRADERM MX 50

ESTRADERM MX 75

ESTRADERM TTS

ESTRADERM TTS 100

ESTRADERM TTS 25

ESTRADERM TTS 50

ESTRADIOL

Estradiol 17 alpha

Estradiol 17 beta

Estradiol 17beta

Estradiol anhydrous

ESTRADIOL HEMIHYDRATE

Estradiol hemihydrate, (17 alpha)-isomer

Estradiol monohydrate

Estradiol orion brand

Estradiol valerate

Estradiol valeriante

Estradiol, (-)-isomer

Estradiol, (+-)-isomer

Estradiol, (16 alpha,17 alpha)-isomer

Estradiol, (16 alpha,17 beta)-isomer

Estradiol, (17-alpha)-isomer

Estradiol, (8 alpha,17 beta)-(+-)-isomer

Estradiol, (8 alpha,17 beta)-isomer

Estradiol, (9 beta,17 alpha)-isomer

Estradiol, (9 beta,17 beta)-isomer

Estradiol, monosodium salt

Estradiol, sodium salt

Estradiol-17 alpha

Estradiol-17 beta

Estradiol-17b

ESTRADIOL-17BETA

ESTRADIOL-17-BETA

Estradiol-17β

ESTRADIOLUM

ESTRADOT

ESTRALDINE

ESTRASORB

ESTRING

ESTRING VAGINAL RING

ESTROCLIM

ESTROCLIM 50

ESTROGEL

ESTROGEL HBF

ESTROGEN

ESTROVITE

EVAMIST

EVOREL

EVOREL 100

EVOREL 25

EVOREL 50

EVOREL 75

FEMATRIX 40

FEMATRIX 80

FEMESTRAL

FEMOGEN

FEMPATCH

FEMSEVEN 100

FEMSEVEN 50

FEMSEVEN 75

FOLLICYCLIN

GELESTRA

GINOSEDOL

GVNODIOL

GYNERGON

GYNODIOL

GYNOESTRYL

GYNOGEN

IMVEXXY

INNOFEM

LAMDIOL

MACRODIOL

MENOREST

MENOREST 37.5

MENOREST 50

MENOREST 75

MENORING 50

MENOSTAR

MINIVELLE

NORDICOL

Novartis pharmaceuticals brand OF estradiol

NSC-20293

NSC-9895

OESCLIM

OESTERGON

OESTRA-1,3,5(10)-TRIENE-3,17B-DIOL

OESTRADIOL

OESTRODIOL

OESTROGEL

OESTROGEN

OESTROGLANDOL

Orion brand OF estradiol

OVAHORMON

OVASTEROL

OVASTEVOL

OVOCYCLIN

OVOCYLIN

PERLATANOL

PRIMOFOL

PROFOLIOL

PROFOLIOL B

PROGYNON

Progynon depot

PROGYNON DH

Progynon-depot

Progynova

PROGYNOVA TS

SANDRENA

SANDRENA 1

SYNDIOL

SYSTEN

VAGIFEM

VAGIFEM 18

VAGIFEM 8

VIVELLE

VIVELLE-DOT

WC3011

WC-3011

ZUMENON

Β-estradiol

16

Polyestradiol phosphate

Approved

28014-46-2

17

Lenograstim

Approved, Investigational

135968-09-1

18

Cyclophosphamide

Approved, Investigational

50-18-0, 6055-19-2

2907

19

Estradiol 3-benzoate

20

Estradiol 17 beta-cypionate

21

Alkylating Agents

22

Antirheumatic Agents

23

Antineoplastic Agents, Alkylating

24

Immunosuppressive Agents

25

Immunologic Factors

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Identification and Clinical Relevance of an Oxytocin Deficient State: a Randomized, Crossover, Placebo-controlled, Proof-of-concept, Physiopathological Study (GLP1 Study)	Recruiting	NCT04897802	Phase 4	Experimental: GLP1-RA (exenatide) administration;Control: Placebo administration
2	Identification and Clinical Relevance of an Oxytocin Deficient State: a Randomized, Crossover, Placebo-controlled, Proof-of-concept Physiopathological Study (CRH Study)	Recruiting	NCT04902235	Phase 4	Experimental: CRH administration;Control: Placebo administration
3	The Physiological Changes in Reproductive Hormones During Sustained Administration of Kisspeptin in Humans.	Unknown status	NCT02081924
4	International Rapid-onset Obesity With Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD) REDCap Registry	Recruiting	NCT03135730
5	High-dose Cyclophosphamide for the Treatment of ROHHAD (Rapid Onset Obesity, Hypoventilation, Hypothalamic Dysfunction, and Autonomic Dysregulation) Syndrome	Active, not recruiting	NCT02441491		Cyclophosphamide

Search NIH Clinical Center for Hypothalamic Disease

Cochrane evidence based reviews: hypothalamic diseases

Sources

Genetic Tests for Hypothalamic Disease

Sources

Anatomical Context for Hypothalamic Disease

Organs/tissues related to Hypothalamic Disease:

MalaCards : Hypothalamus, Pituitary, Testes, Thyroid, Occipital Lobe, Brain, Ovary

Sources

Publications for Hypothalamic Disease

Articles related to Hypothalamic Disease:

(show top 50) (show all 172)

#	Title	Authors	PMID	Year
1	Growth hormone replacement inhibits renal and hepatic 11 beta-hydroxysteroid dehydrogenases in ACTH-deficient patients. ⁵³ ⁶²	Walker BR...Padfield PL	9828916	1998
2	Dynamics of prolactin secretion in patients with hypopituitarism and pituitary macroadenomas. ⁵³ ⁶²	Arafah BM...Selman WR	8530591	1995
3	[Disturbance of hypothalamic-pituitary hormone secretion in familial chorea-acanthocytosis]. ⁵³ ⁶²	Terao S...Sakakibara T	7669403	1995
4	Pathogenesis of pituitary Cushing's syndrome. Pituitary versus hypothalamic. ⁵³ ⁶²	Biller BM	7805653	1994
5	An apparent cluster of congenital hypopituitarism in central Massachusetts: magnetic resonance imaging and hormonal studies. ⁵³ ⁶²	Brown RS...Hayes E	1846002	1991
6	CRH and lysine-vasopressin stimulation tests in the diagnosis of hypoadrenalism secondary to hypothalamic or pituitary disorders. ⁵³ ⁶²	Cantalamessa L...Peracchi G	2169450	1990
7	What Works for One May Not Work for Another: A New Warning for Modafinil. ⁶²	Kim H...Scharf SM	36043022	2022
8	Autoimmunity Related to Adipsic Hypernatremia and ROHHAD Syndrome. ⁶²	Nakamura-Utsunomiya A	35805903	2022
9	A new perspective of hypothalamic disease: Shapiro's syndrome. ⁶²	Ren L...Wang G	35968294	2022
10	Bexarotene-induced central hypothyroidism assessed by TRH stimulation test in cutaneous T-cell lymphoma patients. ⁶²	Toi N...Emoto M	34433736	2022
11	European guideline and expert statements on the management of narcolepsy in adults and children. ⁶²	Bassetti CLA...Lammers GJ	34173288	2021
12	European guideline and expert statements on the management of narcolepsy in adults and children. ⁶²	Bassetti CLA...Lammers GJ	34173695	2021
13	Effects of Childhood Multidisciplinary Care and Growth Hormone Treatment on Health Problems in Adults with Prader-Willi Syndrome. ⁶²	Pellikaan K...de Graaff LCG	34362034	2021
14	Biochemical transition during triphasic postpartum thyroiditis: confusion with central hypothyroidism. ⁶²	Oyibo SO...Sagi SV	34280894	2021
15	Multidisciplinary Approach for Hypothalamic Obesity in Children and Adolescents: A Preliminary Study. ⁶²	Tessaris D...de Sanctis L	34206290	2021
16	Case Report: A Rare Case of Coexisting of Autoimmune Polyglandular Syndrome Type 3 and Isolated Gonadotropin-Releasing Hormone Deficiency. ⁶²	Jiang Q...Li X	34594339	2021
17	"Non-Classical" Indication for Provocative Testing of Growth Hormone: A Retrospective Cohort Study in Adult Patients Under Replacement Therapy. ⁶²	Mancini A...Pontecorvi A	32990548	2021
18	Missed Diagnoses and Health Problems in Adults With Prader-Willi Syndrome: Recommendations for Screening and Treatment. ⁶²	Pellikaan K...de Graaff LCG	32877518	2020
19	Conventional autoantibodies against brain antigens are not routinely detectable in serum and CSF of narcolepsy type 1 and 2 patients. ⁶²	Dietmann A...Bassetti CLA	32858359	2020
20	Testosterone Supplementation Rescues Spermatogenesis and In Vitro Fertilizing Ability of Sperm in Kiss1 Knockout Mice. ⁶²	Goto T...Uenoyama Y	32514526	2020
21	Sarcoidosis and the Nervous System. ⁶²	Pawate S	32487903	2020
22	Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment. ⁶²	Bassetti CLA...Dauvilliers Y	31324898	2019
23	Management of hypothalamic disease in patients with craniopharyngioma. ⁶²	Thompson CJ...Crowley RK	30614015	2019
24	Adipsic Diabetes Insipidus-The Challenging Combination of Polyuria and Adipsia: A Case Report and Review of Literature. ⁶²	Dalan R...Chua KS	31620086	2019
25	A hotspots analysis-relation discovery representation model for revealing diabetes mellitus and obesity. ⁶²	He G...Guan R	30547805	2018
26	Reference intervals for thyrotropin in an area of Northern Italy: the Pordenone thyroid study (TRIPP). ⁶²	Tozzoli R...Bagnasco M	29340973	2018
27	Hypothermia in Multiple Sclerosis: Beyond the Hypothalamus? A Case Report and Review of the Literature. ⁶²	Berti F...Gran B	29755800	2018
28	Pediatric Adrenal Insufficiency: Diagnosis, Management, and New Therapies. ⁶²	Bowden SA...Henry R	30515225	2018
29	[The hypothalamus in Huntington's disease]. ⁶²	Bellosta-Diago E...Lopez Del Val LJ	29071701	2017
30	Diabetes insipidus and hypopituitarism in HIV: an unexpected cause. ⁶²	Tavares Bello C...Vasconcelos C	28620498	2017
31	Central hypothyroidism and its role for cardiovascular risk factors in hypopituitary patients. ⁶²	Feldt-Rasmussen U...Klose M	27481361	2016
32	[Addison's disease : Primary adrenal insufficiency]. ⁶²	Pulzer A...Hahner S	27129928	2016
33	The Evaluation of Adrenal Function in Two Cases of Hypocortisolism Accompanied by Liver Cirrhosis. ⁶²	Yamashita M...Daimon M	27041161	2016
34	Paraneoplastic limbic encephalitis with associated hypothalamitis mimicking a hyperdense hypothalamic tumor: a case report. ⁶²	Bataduwaarachchi VR...Tissera N	26782815	2016
35	Management of Craniopharyngioma - Perspectives beyond Surgery and Endocrinology. ⁶²	Crowley RK...Thompson CJ	29632577	2015
36	Oral manifestations of hypothyroidism: a case report. ⁶²	Gupta R...Gupta S	24995258	2014
37	Psychotropic-induced hyperprolactinemia: a clinical review. ⁶²	Ajmal A...Nachtigall LB	24140188	2014
38	Comparison of body composition, basal metabolic rate and metabolic outcomes of adults with Prader Willi syndrome or lesional hypothalamic disease, with primary obesity. ⁶²	Lloret-Linares C...Poitou C	23318724	2013
39	GLP-1 analogues as a new treatment option for hypothalamic obesity in adults: report of nine cases. ⁶²	Zoicas F...Schofl C	23392214	2013
40	Hypothalamic germinoma masquerading as superior mesenteric artery (SMA) syndrome. ⁶²	Vethakkan SR...Choong K	23186972	2013
41	Development and validation of a new questionnaire assessing quality of life in adults with hypopituitarism: Adult Hypopituitarism Questionnaire (AHQ). ⁶²	Ishii H...Chihara K	22984490	2012
42	Management of subclinical hyperthyroidism. ⁶²	Santos Palacios S...Galofre JC	23843809	2012
43	Partial hypopituitarism and Langerhans cell histiocytosis. ⁶²	Balaguruswamy S...Chattington PD	22715201	2011
44	Disorder in the serotonergic system due to tryptophan hydroxylation impairment: a cause of hypothalamic syndrome? ⁶²	Schott DA...Gerver WJ	20190542	2010
45	Slow-growing craniopharyngioma masquarading as early-onset eating disorder: two cases. ⁶²	Vad Winkler L...Stoving RK	19115368	2009
46	[Visual pathway and pituitary stalk protection in pituitary tumor surgery and the clinical outcome]. ⁶²	Gong SP...Yang QY	19246307	2009
47	Clinical perspectives on the genetics of schizophrenia: a bottom-up orientation. ⁶²	Verhoeven WM...Tuinier S	19073422	2008
48	Androgens may mediate a relative preservation of IGF-I levels in overweight and obese women despite reduced growth hormone secretion. ⁶²	Utz AL...Miller KK	18647804	2008
49	Diagnostic usefulness of the growth hormone-releasing peptide-2 test as a substitute for the insulin tolerance test in hypopituitarism. ⁶²	Kageyama K...Suda T	18493103	2008
50	Growth hormone deficiency by growth hormone releasing hormone-arginine testing criteria predicts increased cardiovascular risk markers in normal young overweight and obese women. ⁶²	Utz AL...Miller KK	18445664	2008

Sources

Genes for Hypothalamic Disease

Genes related to Hypothalamic Disease (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	PRL	Prolactin	Protein Coding	13.25	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	8530591 2174755 7669403 (more) 1846002
2	CRH	Corticotropin Releasing Hormone	Protein Coding	13.06	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	8393256 7805653 2169450
3	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	11.68	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	9758439 7921222 2132474
4	GH1	Growth Hormone 1	Protein Coding	11.44	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	9828916
5	POMC	Proopiomelanocortin	Protein Coding	6.59	DISEASES inferred ¹⁴
6	TRH	Thyrotropin Releasing Hormone	Protein Coding	6.54	DISEASES inferred ¹⁴
7	GHRH	Growth Hormone Releasing Hormone	Protein Coding	6.17	DISEASES inferred ¹⁴
8	AVP	Arginine Vasopressin	Protein Coding	5.58	DISEASES inferred ¹⁴
9	INS	Insulin	Protein Coding	5.56	DISEASES inferred ¹⁴
10	HCRT	Hypocretin Neuropeptide Precursor	Protein Coding	5.28	DISEASES inferred ¹⁴
11	IGF1	Insulin Like Growth Factor 1	Protein Coding	5.23	DISEASES inferred ¹⁴
12	TSHB	Thyroid Stimulating Hormone Subunit Beta	Protein Coding	5.1	DISEASES inferred ¹⁴

Sources

Variations for Hypothalamic Disease

Sources

Expression for Hypothalamic Disease

Search GEO for disease gene expression data for Hypothalamic Disease.

Sources

Pathways for Hypothalamic Disease

Pathways related to Hypothalamic Disease according to GeneCards Suite gene sharing:

(show all 21)

#	Super pathways	Score	Top Affiliating Genes
1	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.28	PRL INS IGF1 GNRH1 GHRH GH1
2	GPCR downstream signalling ⁶⁶ Show member pathways G alpha (i) signalling events ⁶⁶ G alpha (q) signalling events ⁶⁶ Signaling by GPCR ⁶⁶	13.28	TSHB TRH POMC HCRT GNRH1 GHRH
3	Class A/1 (Rhodopsin-like receptors) ⁶⁶ Show member pathways GPCR ligand binding ⁶⁶ GPCRs, class A rhodopsin-like ⁷⁴ Peptide GPCRs ⁷⁴ Peptide ligand-binding receptors ⁶⁶	12.99	AVP CRH GHRH GNRH1 HCRT POMC
4	p70S6K Signaling ⁶⁴ Show member pathways mTOR Pathway ⁶⁴ Renin-Angiotensin Pathway ⁶⁴	12.78	INS IGF1 GNRH1 GHRH GH1
5	Signal Transduction ⁶⁶	12.74	TSHB TRH POMC INS IGF1 HCRT
6	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.46	IGF1 GNRH1 GHRH GH1
7	G-Beta Gamma Signaling ⁶⁴ Show member pathways CRHR Pathway ⁶⁴ GHRH Signaling ⁶⁴	12.41	POMC GHRH GH1 CRH
8	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.4	IGF1 GNRH1 GHRH GH1
9	G-protein signaling RAC1 in cellular process ²² Show member pathways CDC42 signaling events ⁶¹ Cytoskeleton remodeling CDC42 in cellular processes ²² RAC1 signaling pathway ⁶¹	12.14	IGF1 GNRH1 GHRH GH1
10	Adipogenesis ⁷⁴	11.84	GH1 IGF1 INS
11	Peptide hormone metabolism ⁶⁶ Show member pathways Glycoprotein hormones ⁶⁶ Metabolism of Angiotensinogen to Angiotensins ⁶⁶ Metabolism of Angiotensinogen to Angiotensins ⁷⁴ Peptide hormone biosynthesis ⁶⁶ Synthesis, secretion, and deacylation of Ghrelin ⁶⁶ thyroid hormone biosynthesis ⁶¹	11.78	TSHB POMC INS IGF1 GH1
12	G alpha (s) signalling events ⁶⁶ Show member pathways Defective ACTH causes obesity and POMCD ⁶⁶	11.56	TSHB POMC GHRH CRH AVP
13	Thyroid hormones production and peripheral downstream signaling effects ⁷⁴	11.55	POMC TRH TSHB
14	G-protein signaling_RhoA regulation pathway ²²	11.47	IGF1 GNRH1 GHRH GH1
15	Prader-Willi and Angelman syndrome ⁷⁴	11.4	POMC INS GNRH1 GHRH
16	Development_Leptin signaling via JAK/STAT and MAPK cascades ²² Show member pathways phospho-PLA2 pathway ⁶⁶	11.07	TRH POMC
17	Serotonin and anxiety ⁷⁴ Show member pathways Serotonin and anxiety-related events ⁷⁴	11.05	POMC CRH
18	Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics ⁶⁰	10.85	PRL POMC INS
19	G-protein signaling_Rap2B regulation pathway ²²	10.78	IGF1 GNRH1 GHRH GH1
20	Hormone ligand-binding receptors ⁶⁶	10.59	TSHB GNRH1
21	Glucocorticoid Pathway (HPA Axis), Pharmacodynamics ⁶⁰	10.28	POMC CRH

Sources

GO Terms for Hypothalamic Disease

Cellular components related to Hypothalamic Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.96	AVP CRH GH1 GHRH GNRH1 IGF1
2	secretory granule	GO:0030141	9.86	TRH POMC HCRT AVP
3	extracellular region	GO:0005576	9.7	TSHB TRH PRL POMC INS IGF1
4	endosome lumen	GO:0031904	9.63	PRL INS GH1

Biological processes related to Hypothalamic Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	10.03	AVP CRH GH1 GNRH1 IGF1 INS
2	positive regulation of cell population proliferation	GO:0008284	10.02	PRL INS IGF1 GHRH AVP
3	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	9.85	INS IGF1 GH1
4	positive regulation of glycogen biosynthetic process	GO:0045725	9.71	INS IGF1
5	negative regulation of transmission of nerve impulse	GO:0051970	9.56	HCRT AVP
6	cell-cell signaling	GO:0007267	9.47	TSHB TRH POMC INS GNRH1 GHRH
7	positive regulation of insulin-like growth factor receptor signaling pathway	GO:0043568	9.43	IGF1 GHRH GH1

Molecular functions related to Hypothalamic Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:0005179	9.6	TSHB TRH PRL POMC INS IGF1
2	insulin-like growth factor receptor binding	GO:0005159	9.56	INS IGF1
3	neuropeptide hormone activity	GO:0005184	9.56	HCRT GHRH CRH AVP
4	prolactin receptor binding	GO:0005148	9.46	PRL GH1

Sources

Sources for Hypothalamic Disease

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: HYP085 MIFTS: 40	Hypothalamic Disease Categories: Endocrine diseases, Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Drugs Expand all tables