Hypothalamic Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HYP085 MIFTS: 38	Hypothalamic Disease Categories: Endocrine diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

Sources

Aliases & Classifications for Hypothalamic Disease

MalaCards integrated aliases for Hypothalamic Disease:

Name: Hypothalamic Disease ¹² ¹⁵

Hypothalamic Diseases ⁴⁴ ⁷⁰

Hypothalamic Dysfunction Syndromes ⁷⁰

Hypothalamic Dysfunction ⁷³

Hypothalamic Disorder ⁵⁴

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Endocrine, nutritional and metabolic diseases

Disorders of other endocrine glands

Hypofunction and other disorders of pituitary gland

Hypothalamic dysfunction, not elsewhere classified

External Ids:

Disease Ontology ¹² DOID:1931

MeSH ⁴⁴ D007027

SNOMED-CT ⁶⁷ 88108008

ICD10 ³² E23.3

UMLS ⁷⁰ C0020655 C0751230

Sources

Summaries for Hypothalamic Disease

MalaCards based summary : Hypothalamic Disease, also known as hypothalamic diseases, is related to precocious puberty and hypogonadism. An important gene associated with Hypothalamic Disease is PRL (Prolactin), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Cyclophosphamide and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and hypothalamus, and related phenotypes are endocrine/exocrine gland and liver/biliary system

Wikipedia : ⁷³ Hypopituitarism is the decreased (hypo) secretion of one or more of the eight hormones normally produced... more...

Sources

Related Diseases for Hypothalamic Disease

Diseases related to Hypothalamic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 299)

#	Related Disease	Score	Top Affiliating Genes
1	precocious puberty	30.5	GNRH1 GH1
2	hypogonadism	30.2	PRL INS GNRH1
3	hypothalamic obesity	30.0	INS GHRH
4	gangliocytoma	29.9	PRL POMC GHRH CRH
5	neurotic disorder	29.9	POMC INS
6	pituitary tumors	29.8	PRL POMC GH1
7	polycystic ovary syndrome	29.8	PRL INS GNRH1 GH1
8	mental depression	29.7	POMC INS CRH
9	amenorrhea	29.6	TRH PRL POMC INS GNRH1 CRH
10	hypogonadotropic hypogonadism	29.6	PRL INS GNRH1
11	anovulation	29.6	PRL INS GNRH1 CRH
12	diabetes insipidus	29.6	PRL POMC INS GH1 CRH AVP
13	craniopharyngioma	29.5	TRH PRL INS GNRH1 GH1
14	sexual disorder	29.5	PRL POMC INS GNRH1
15	hyperandrogenism	29.5	PRL POMC INS GNRH1
16	major depressive disorder	29.4	PRL POMC HCRT CRH
17	hypoglycemia	29.4	PRL POMC INS GH1 CRH
18	body mass index quantitative trait locus 11	29.2	TRH POMC INS HCRT GHRH GH1
19	ovarian disease	29.2	PRL POMC INS GNRH1 GH1
20	hyperprolactinemia	29.2	TRH PRL POMC INS GNRH1 GHRH
21	anxiety	29.1	PRL POMC INS HCRT CRH
22	anorexia nervosa	29.0	PRL POMC INS HCRT GHRH GH1
23	sleep disorder	29.0	PRL POMC INS HCRT CRH
24	adenoma	29.0	TRH PRL POMC GHRH GH1 CRH
25	hypothyroidism	28.7	TSHB TRH PRL POMC INS GNRH1
26	hypopituitarism	28.6	TRH PRL POMC INS GNRH1 GHRH
27	pituitary hormone deficiency, combined, 2	28.5	TSHB TRH PRL POMC GHRH GH1
28	prader-willi syndrome	28.5	TRH PRL POMC INS HCRT GNRH1
29	acromegaly	28.3	TRH PRL POMC INS GNRH1 GHRH
30	pituitary adenoma	28.2	TSHB TRH PRL POMC GNRH1 GHRH
31	pituitary gland disease	28.1	TSHB TRH PRL POMC INS GNRH1
32	rohhad	11.5
33	rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome	11.4
34	shapiro syndrome	11.1
35	fryns microphthalmia syndrome	11.1
36	froelich syndrome	10.9
37	sexual sadism	10.3	PRL CRH
38	fibrous dysplasia/mccune-albright syndrome	10.3	PRL GH1
39	pyometritis	10.3	PRL GNRH1
40	body mass index quantitative trait locus 9	10.3
41	body mass index quantitative trait locus 8	10.3
42	body mass index quantitative trait locus 4	10.3
43	body mass index quantitative trait locus 10	10.3
44	body mass index quantitative trait locus 7	10.3
45	body mass index quantitative trait locus 12	10.3
46	body mass index quantitative trait locus 14	10.3
47	body mass index quantitative trait locus 18	10.3
48	body mass index quantitative trait locus 19	10.3
49	generalized resistance to thyroid hormone	10.3	TRH PRL
50	partial third-nerve palsy	10.3	PRL GH1

Graphical network of the top 20 diseases related to Hypothalamic Disease:

Sources

Symptoms & Phenotypes for Hypothalamic Disease

MGI Mouse Phenotypes related to Hypothalamic Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	9.8	CRH GHRH GNRH1 INS POMC PRL
2	liver/biliary system	MP:0005370	9.63	CRH GHRH GNRH1 INS POMC PRL
3	nervous system	MP:0003631	9.61	AVP CRH GHRH GNRH1 HCRT INS
4	renal/urinary system	MP:0005367	9.1	AVP CRH GNRH1 INS POMC TRH

Sources

Drugs & Therapeutics for Hypothalamic Disease

Drugs for Hypothalamic Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Cyclophosphamide

Approved, Investigational

50-18-0, 6055-19-2

2907

Synonyms:

(-)-Cyclophosphamide

(+-)-Cyclophosphamide

(+,-)-2-(Bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate

(RS)-Cyclophosphamide

1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine

1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin

2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide

4-Hydroxy-cyclophosphan-mamophosphatide

50-18-0

60007-95-6

6055-19-2 (monohydrate)

75526-90-8

AC1L1EQQ

AI3-26198

Anhydrous cyclophosphamide

Anhydrous, cyclophosphamide

ASTA

Asta B 518

ASTA B518

B 518

B-518

bis(2-Chloroethyl)phosphami de cyclic propanolamide

bis(2-Chloroethyl)phosphamide cyclic propanolamide ester

Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester

BRN 0011744

BSPBio_002099

C 0768

C07888

C7H15Cl2N2O2P

CB 4564

CB-4564

CCRIS 188

CHEBI:4027

CHEMBL32520

CHEMBL88

Ciclofosfamida

Ciclofosfamida [INN-Spanish]

Ciclofosfamide

Ciclophosphamide

Ciclophosphamide [INN]

CID2907

Clafen

Claphene

CPA

CTX

Cycloblastin

Cyclophosphamid

cyclophosphamide

Cyclophosphamide

Cyclophosphamide (anhydrous form)

Cyclophosphamide (anhydrous)

Cyclophosphamide (INN)

Cyclophosphamide (TN)

Cyclophosphamide anhydrous

Cyclophosphamide monohydrate

Cyclophosphamide Monohydrate

Cyclophosphamide Sterile

Cyclophosphamide, (+-)-Isomer

Cyclophosphamide, (R)-isomer

Cyclophosphamide, (S)-isomer

Cyclophosphamides

Cyclophosphamidum

Cyclophosphamidum [INN-Latin]

Cyclophosphan

Cyclophosphane

Cyclophosphanum

Cyclophosphoramide

Cyclostin

Cyklofosfamid

Cyklofosfamid [Czech]

Cytophosphan

Cytophosphane

Cytoxan

Cytoxan (TN)

Cytoxan Lyoph

D,L-Cyclophosphamide

D07760

DB00531

DivK1c_000246

EINECS 200-015-4

Endoxan

Endoxan R

Endoxana

Endoxanal

Endoxan-Asta

Endoxane

Enduxan

EU-0100238

Genoxal

Hexadrin

HMS2090A12

HSDB 3047

IDI1_000246

KBio1_000246

KBio2_001338

KBio2_003906

KBio2_006474

KBio3_001319

KBioGR_000888

KBioSS_001338

Lopac0_000238

Lopac-C-0768

LS-1302

LS-99787

Lyophilized Cytoxan

Mitoxan

MolPort-001-783-420

Monohydrate, cyclophosphamide

N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide

N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

NCGC00015209-01

NCGC00015209-03

NCGC00015209-06

NCGC00091741-02

NCGC00091741-03

NCI60_002097

NCI-C04900

Neosar

NINDS_000246

NSC 26271

NSC26271

NSC-26271

NSC273033

NSC273034

Occupation, cyclophosphamide exposure

Procytox

RCRA waste no. U058

Rcra waste number U058

Rcra Waste Number U058

Revimmune

S1217_Selleck

Semdoxan

Sendoxan

Senduxan

SK 20501

SPBio_001071

Spectrum_000858

Spectrum2_001146

Spectrum3_000370

Spectrum4_000304

Spectrum5_000795

STK177249

STOCK2S-91217

UNII-6UXW23996M

WLN: T6MPOTJ BO BN2G2G

Zyklophosphamid

Zyklophosphamid [German]

Lenograstim

Approved, Investigational

135968-09-1

Immunologic Factors

Immunosuppressive Agents

Antirheumatic Agents

Alkylating Agents

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	International Rapid-onset Obesity With Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD) REDCap Registry	Recruiting	NCT03135730
2	High-dose Cyclophosphamide for the Treatment of ROHHAD (Rapid Onset Obesity, Hypoventilation, Hypothalamic Dysfunction, and Autonomic Dysregulation) Syndrome	Active, not recruiting	NCT02441491		Cyclophosphamide

Search NIH Clinical Center for Hypothalamic Disease

Cochrane evidence based reviews: hypothalamic diseases

Sources

Genetic Tests for Hypothalamic Disease

Sources

Anatomical Context for Hypothalamic Disease

MalaCards organs/tissues related to Hypothalamic Disease:

⁴⁰

Pituitary, Thyroid, Hypothalamus, Bone, Cerebellum, Occipital Lobe, Pineal

Sources

Publications for Hypothalamic Disease

Articles related to Hypothalamic Disease:

(show top 50) (show all 104)

#	Title	Authors	PMID	Year
1	Growth hormone replacement inhibits renal and hepatic 11 beta-hydroxysteroid dehydrogenases in ACTH-deficient patients. ⁵⁴ ⁶¹	Walker BR...Padfield PL	9828916	1998
2	Dynamics of prolactin secretion in patients with hypopituitarism and pituitary macroadenomas. ⁶¹ ⁵⁴	Arafah BM...Selman WR	8530591	1995
3	An apparent cluster of congenital hypopituitarism in central Massachusetts: magnetic resonance imaging and hormonal studies. ⁵⁴ ⁶¹	Brown RS...Hayes E	1846002	1991
4	Is HPV the Novel Target in Male Idiopathic Infertility? A Systematic Review of the Literature. ⁶¹	Muscianisi F...Garolla A	33763033	2021
5	"Non-classical" indication for provocative testing of growth hormone: a retrospective cohort study in adult patients under replacement therapy. ⁶¹	Mancini A...Pontecorvi A	32990548	2020
6	Sarcoidosis and the Nervous System. ⁶¹	Pawate S	32487903	2020
7	Is the Cerebellum Involved in the Nervous Control of the Immune System Function? ⁶¹	Rizzi A...Benagiano V	31729296	2020
8	Management of hypothalamic disease in patients with craniopharyngioma. ⁶¹	Thompson CJ...Crowley RK	30614015	2019
9	A hotspots analysis-relation discovery representation model for revealing diabetes mellitus and obesity. ⁶¹	He G...Guan R	30547805	2018
10	Reference intervals for thyrotropin in an area of Northern Italy: the Pordenone thyroid study (TRIPP). ⁶¹	Tozzoli R...Bagnasco M	29340973	2018
11	Pediatric Adrenal Insufficiency: Diagnosis, Management, and New Therapies. ⁶¹	Bowden SA...Henry R	30515225	2018
12	Hypothermia in Multiple Sclerosis: Beyond the Hypothalamus? A Case Report and Review of the Literature. ⁶¹	Berti F...Gran B	29755800	2018
13	Generation and Characterization of Functional Human Hypothalamic Neurons. ⁶¹	Kirwan P...Merkle FT	29064566	2017
14	Diabetes insipidus and hypopituitarism in HIV: an unexpected cause. ⁶¹	Tavares Bello C...Vasconcelos C	28620498	2017
15	Central hypothyroidism and its role for cardiovascular risk factors in hypopituitary patients. ⁶¹	Feldt-Rasmussen U...Klose M	27481361	2016
16	[Addison's disease : Primary adrenal insufficiency]. ⁶¹	Pulzer A...Hahner S	27129928	2016
17	Paraneoplastic limbic encephalitis with associated hypothalamitis mimicking a hyperdense hypothalamic tumor: a case report. ⁶¹	Bataduwaarachchi VR...Tissera N	26782815	2016
18	Management of Craniopharyngioma - Perspectives beyond Surgery and Endocrinology. ⁶¹	Crowley RK...Thompson CJ	29632577	2015
19	Oral manifestations of hypothyroidism: a case report. ⁶¹	Gupta R...Gupta S	24995258	2014
20	Psychotropic-induced hyperprolactinemia: a clinical review. ⁶¹	Ajmal A...Nachtigall LB	24140188	2014
21	Comparison of body composition, basal metabolic rate and metabolic outcomes of adults with Prader Willi syndrome or lesional hypothalamic disease, with primary obesity. ⁶¹	Lloret-Linares C...Poitou C	23318724	2013
22	GLP-1 analogues as a new treatment option for hypothalamic obesity in adults: report of nine cases. ⁶¹	Zoicas F...Schofl C	23392214	2013
23	Hypothalamic germinoma masquerading as superior mesenteric artery (SMA) syndrome. ⁶¹	Vethakkan SR...Choong K	23186972	2013
24	Management of subclinical hyperthyroidism. ⁶¹	Santos Palacios S...Galofre JC	23843809	2012
25	Partial hypopituitarism and Langerhans cell histiocytosis. ⁶¹	Balaguruswamy S...Chattington PD	22715201	2011
26	Androgens may mediate a relative preservation of IGF-I levels in overweight and obese women despite reduced growth hormone secretion. ⁶¹	Utz AL...Miller KK	18647804	2008
27	Growth hormone deficiency by growth hormone releasing hormone-arginine testing criteria predicts increased cardiovascular risk markers in normal young overweight and obese women. ⁶¹	Utz AL...Miller KK	18445664	2008
28	Hypopituitarism. ⁶¹	Ascoli P...Cavagnini F	17077946	2006
29	Gene-transfer technology: a preventive neurotherapy to curb obesity, ameliorate metabolic syndrome and extend life expectancy. ⁶¹	Kalra SP...Kalra PS	16125798	2005
30	Neurocognitive function in adults with growth hormone deficiency. ⁶¹	van Dam PS	16439853	2005
31	Is the thyrotropin-releasing hormone test necessary in the diagnosis of central hypothyroidism in children. ⁶¹	Mehta A...Dattani MT	14671155	2003
32	Osteopenic mice: animal models of the aging skeleton. ⁶¹	Priemel M...Amling M	15758436	2002
33	Diagnosis and management of growth hormone deficiency in adults. ⁶¹	Stavrou S...Kleinberg DL	11571930	2001
34	Serum thyroid-stimulating hormone measurement for assessment of thyroid function and disease. ⁶¹	Ross DS	11444162	2001
35	Basal, pulsatile, entropic, and 24-hour rhythmic features of secondary hyperprolactinemia due to functional pituitary stalk disconnection mimic tumoral (primary) hyperprolactinemia. ⁶¹	Veldman RG...Roelfsema F	11297584	2001
36	Central control of bone formation. ⁶¹	Takeda S...Karsenty G	11368306	2001
37	Pituitary-thyroid feedback hypersensitivity as a novel cause of hypothyroidism in children. ⁶¹	Frankton S...Williams GR	11072946	2000
38	Experience with cyproterone acetate in the treatment of precocious puberty. ⁶¹	Laron Z...Kauli R	10969925	2000
39	Kleine-Levin and Munchausen syndromes in a patient with recurrent acromegaly. ⁶¹	Jungheim K...Usadel KH	10069657	1999
40	Pulsatile GnRH or human chorionic gonadotropin/human menopausal gonadotropin as effective treatment for men with hypogonadotropic hypogonadism: a review of 42 cases. ⁵⁴	Buchter D...Nieschlag E	9758439	1998
41	Clinical review 86: Euthyroid sick syndrome: is it a misnomer? ⁶¹	Chopra IJ	9024211	1997
42	Obese (ob) gene defects are rare in human obesity. ⁶¹	Carlsson B...Carlsson LM	9061713	1997
43	Hypothalamic disease: neurosecretory dysfunction and parasellar lesions. ⁶¹	Bercu BB	9174692	1997
44	Hyperprolactinemia. ⁶¹	Kaye TB	29224529	1996
45	A comparison between short ACTH and insulin stress tests for assessing hypothalamo-pituitary-adrenal function. ⁶¹	Ammari F...Scanion MF	8706316	1996
46	Endocrine abnormalities in hemodialysis patients with iron overload: reversal with iron depletion. ⁶¹	el-Reshaid K...Kamel H	8748213	1995
47	[Disturbance of hypothalamic-pituitary hormone secretion in familial chorea-acanthocytosis]. ⁵⁴	Terao S...Sakakibara T	7669403	1995
48	High efficacy of gonadotropin or pulsatile gonadotropin-releasing hormone treatment in hypogonadotropic hypogonadal men. ⁵⁴	Kliesch S...Nieschlag E	7921222	1994
49	Pathogenesis of pituitary Cushing's syndrome. Pituitary versus hypothalamic. ⁵⁴	Biller BM	7805653	1994
50	Chronic hypothermia and water intoxication associated with a neurodegenerative disease. ⁶¹	Corbett EL...Sarkar D	8121871	1993

Sources

Genes for Hypothalamic Disease

Genes related to Hypothalamic Disease (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	PRL	Prolactin	Protein Coding	13.22	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	8530591 2174755 7669403 (more) 1846002
2	CRH	Corticotropin Releasing Hormone	Protein Coding	13.1	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	8393256 7805653 2169450
3	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	11.85	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	9758439 7921222 2132474
4	GH1	Growth Hormone 1	Protein Coding	11.4	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	9828916
5	TRH	Thyrotropin Releasing Hormone	Protein Coding	6.9	DISEASES inferred ¹⁵
6	POMC	Proopiomelanocortin	Protein Coding	6.8	DISEASES inferred ¹⁵
7	GHRH	Growth Hormone Releasing Hormone	Protein Coding	6.53	DISEASES inferred ¹⁵
8	INS	Insulin	Protein Coding	5.81	DISEASES inferred ¹⁵
9	AVP	Arginine Vasopressin	Protein Coding	5.71	DISEASES inferred ¹⁵
10	TSHB	Thyroid Stimulating Hormone Subunit Beta	Protein Coding	5.6	DISEASES inferred ¹⁵
11	PNMA1	PNMA Family Member 1	Protein Coding	5.53	DISEASES inferred ¹⁵
12	HCRT	Hypocretin Neuropeptide Precursor	Protein Coding	5.45	DISEASES inferred ¹⁵

Sources

Variations for Hypothalamic Disease

Sources

Expression for Hypothalamic Disease

Search GEO for disease gene expression data for Hypothalamic Disease.

Sources

Pathways for Hypothalamic Disease

Pathways related to Hypothalamic Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Signaling by GPCR ⁶⁵ Show member pathways GPCR downstream signaling ⁶⁵ Signal Transduction ⁶⁵	13.75	TSHB TRH POMC INS HCRT GNRH1
2	Peptide ligand-binding receptors ⁶⁵ Show member pathways Class A/1 (Rhodopsin-like receptors) ⁶⁵ Defective AVP causes neurohypophyseal diabetes insipidus (NDI) ⁶⁵ Formyl peptide receptors bind formyl peptides and many other ligands ⁶⁵ G alpha (i) signalling events ⁶⁵ GPCR ligand binding ⁶⁵ GPCRs, Class A Rhodopsin-like ¹ Neuroactive ligand-receptor interaction ³⁶ Orexin and neuropeptides FF and QRFP bind to their respective receptors ⁶⁵ Peptide GPCRs ¹ Tachykinin receptors bind tachykinins ⁶⁵ Vasopressin-like receptors ⁶⁵	12.6	TSHB TRH PRL POMC HCRT GNRH1
3	Aldosterone synthesis and secretion ³⁶ Show member pathways Ca2+ activated K+ channels ⁶⁵ Cortisol synthesis and secretion ³⁶ Cushing syndrome ³⁶ Insulin secretion ³⁶ Melanogenesis ³⁶ Thyroid hormone synthesis ³⁶	12.55	TSHB POMC INS CRH
4	Circadian rythm related genes ¹	11.95	GHRH CRH AVP
5	Peptide hormone metabolism ⁶⁵ Show member pathways Glycoprotein hormones ⁶⁵ Insulin processing ⁶⁵ Metabolism of Angiotensinogen to Angiotensins ⁶⁵ Peptide hormone biosynthesis ⁶⁵ Synthesis, secretion, and deacylation of Ghrelin ⁶⁵	11.82	TSHB POMC INS GH1
6	G alpha (s) signalling events ⁶⁵	11.52	TSHB POMC GHRH CRH AVP
7	Development_Leptin signaling via JAK/STAT and MAPK cascades ²³ Show member pathways phospho-PLA2 pathway ⁶⁵	10.91	TRH POMC
8	Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics ⁶⁰	10.63	PRL POMC INS
9	Hormone ligand-binding receptors ⁶⁵	10.48	TSHB GNRH1
10	Glucocorticoid Pathway (HPA Axis), Pharmacodynamics ⁶⁰	10.17	POMC CRH

Sources

GO Terms for Hypothalamic Disease

Cellular components related to Hypothalamic Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.61	TSHB PRL POMC INS GNRH1 GHRH
2	secretory granule	GO:0030141	9.56	TRH POMC HCRT AVP
3	perikaryon	GO:0043204	9.5	GNRH1 GHRH CRH
4	extracellular region	GO:0005576	9.36	TSHB TRH PRL POMC INS HCRT
5	endosome lumen	GO:0031904	9.33	PRL INS GH1

Biological processes related to Hypothalamic Disease according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	9.86	TRH PRL POMC INS GNRH1 GH1
2	positive regulation of cell proliferation	GO:0008284	9.77	PRL INS GHRH CRH AVP
3	response to organic cyclic compound	GO:0014070	9.67	TRH GNRH1 AVP
4	female pregnancy	GO:0007565	9.61	PRL GNRH1 CRH
5	G protein-coupled receptor signaling pathway	GO:0007186	9.61	TSHB TRH POMC INS HCRT GNRH1
6	response to testosterone	GO:0033574	9.56	GNRH1 AVP
7	positive regulation of JAK-STAT cascade	GO:0046427	9.55	PRL GH1
8	positive regulation of multicellular organism growth	GO:0040018	9.54	GHRH GH1
9	eating behavior	GO:0042755	9.52	TRH HCRT
10	response to corticosterone	GO:0051412	9.51	TRH CRH
11	JAK-STAT cascade involved in growth hormone signaling pathway	GO:0060397	9.48	PRL GH1
12	positive regulation of insulin-like growth factor receptor signaling pathway	GO:0043568	9.46	GHRH GH1
13	response to ethanol	GO:0045471	9.46	TRH GNRH1 CRH AVP
14	negative regulation of feeding behavior	GO:2000252	9.4	TRH INS
15	negative regulation of transmission of nerve impulse	GO:0051970	9.32	HCRT AVP
16	cell-cell signaling	GO:0007267	9.17	TSHB TRH POMC INS GNRH1 GHRH

Molecular functions related to Hypothalamic Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:0005179	9.32	TSHB TRH PRL POMC INS GNRH1
2	neuropeptide hormone activity	GO:0005184	9.26	HCRT GHRH CRH AVP
3	prolactin receptor binding	GO:0005148	9.16	PRL GH1

Sources

Sources for Hypothalamic Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia