Hypothalamic Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Hypothalamic Disease, also known as hypothalamic diseases, is related to precocious puberty and diabetes insipidus, neurohypophyseal. An important gene associated with Hypothalamic Disease is PRL (Prolactin), and among its related pathways/superpathways are TGF-Beta Pathway and GPCR downstream signalling. The drugs Exenatide and Oxytocin have been mentioned in the context of this disorder. Affiliated tissues include hypothalamus, pituitary and testes, and related phenotypes are nervous system and homeostasis/metabolism

Wikipedia: ⁷⁵ Hypothalamic disease is a disorder presenting primarily in the hypothalamus, which may be caused by... more...

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Related Diseases for Hypothalamic Disease

Diseases related to Hypothalamic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 387, show less)

#	Related Disease	Score	Top Affiliating Genes
1	precocious puberty	30.5	GNRH1 GH1
2	diabetes insipidus, neurohypophyseal	30.3	POMC AVP
3	premature ovarian failure 7	30.1	POMC GH1 CRH
4	hypothyroidism, congenital, nongoitrous, 1	30.0	TSHB GHRH
5	diabetes insipidus	29.7	PRL POMC INS GH1 CRH AVP
6	neurotic disorder	29.7	POMC INS CRH
7	galactorrhea	29.7	PRL IGF1
8	inappropriate adh syndrome	29.5	PRL POMC CRH AVP
9	pituitary tumors	29.4	PRL IGF1 GH1
10	hypogonadism	29.3	PRL POMC INS IGF1 GNRH1 GH1
11	panic disorder	29.3	TRH PRL POMC GHRH CRH
12	sleep apnea	29.2	INS IGF1 HCRT
13	prediabetes syndrome	29.2	INS IGF1 GH1
14	central diabetes insipidus	29.2	TRH PRL POMC IGF1 GNRH1 GH1
15	overnutrition	29.1	POMC INS IGF1
16	hypogonadotropic hypogonadism	29.1	PRL POMC INS IGF1 GNRH1
17	pituitary-dependent cushing's disease	29.1	TRH PRL POMC GHRH GH1 CRH
18	apnea, obstructive sleep	29.0	POMC INS IGF1 HCRT
19	amenorrhea	28.9	TRH PRL POMC INS IGF1 GNRH1
20	mccune-albright syndrome	28.9	PRL POMC IGF1 GHRH GH1
21	anovulation	28.9	PRL INS IGF1 GNRH1 CRH
22	craniopharyngioma	28.9	TRH PRL INS IGF1 GNRH1 GH1
23	polycystic ovary syndrome	28.8	PRL POMC INS IGF1 GNRH1 GH1
24	ovarian disease	28.8	PRL POMC INS IGF1 GNRH1
25	insulin-like growth factor i	28.8	PRL INS IGF1 GHRH GH1
26	hyperandrogenism	28.6	PRL POMC INS IGF1 GNRH1 GH1
27	leptin deficiency or dysfunction	28.5	TRH POMC INS IGF1 HCRT GNRH1
28	sleep disorder	28.5	POMC INS IGF1 HCRT CRH
29	major depressive disorder	28.4	TRH PRL POMC INS HCRT CRH
30	anorexia nervosa	28.4	PRL POMC INS IGF1 HCRT GHRH
31	empty sella syndrome	28.3	TRH PRL POMC INS IGF1 GNRH1
32	hypopituitarism	28.3	TRH PRL POMC INS IGF1 GNRH1
33	hypothyroidism	28.2	TSHB TRH PRL POMC INS IGF1
34	hypoglycemia	28.2	TRH PRL POMC INS IGF1 GHRH
35	adenoma	28.0	TSHB TRH PRL POMC IGF1 GHRH
36	hyperprolactinemia	27.9	TRH PRL POMC INS IGF1 GNRH1
37	pituitary hormone deficiency, combined, 2	27.8	TSHB TRH PRL POMC IGF1 GNRH1
38	pituitary adenoma	27.7	TSHB TRH PRL POMC IGF1 GNRH1
39	acromegaly	27.7	TRH PRL POMC INS IGF1 GNRH1
40	pituitary gland disease	27.7	TSHB TRH PRL POMC INS IGF1
41	conn's syndrome	27.5	TRH PRL POMC INS IGF1 GNRH1
42	prader-willi syndrome	27.4	TRH PRL POMC INS IGF1 HCRT
43	body mass index quantitative trait locus 11	27.2	TRH PRL POMC INS IGF1 HCRT
44	rohhad	11.6
45	rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome	11.6
46	fryns microphthalmia syndrome	11.1
47	froelich syndrome	10.9
48	leydig cell hypoplasia type ii	10.3	PRL GNRH1
49	pyometritis	10.3	PRL GNRH1
50	chiasmal syndrome	10.3	PRL POMC
51	polyp of corpus uteri	10.3	PRL GNRH1
52	rete ovarii adenoma	10.3	PRL GNRH1
53	rete ovarii benign neoplasm	10.3	PRL GNRH1
54	waterhouse-friderichsen syndrome	10.3	POMC CRH
55	mediastinal lipomatosis	10.3	POMC CRH
56	submucous uterine fibroid	10.3	PRL GNRH1
57	premenstrual tension	10.2	POMC GNRH1
58	abducens palsy	10.2	PRL POMC
59	estrogen excess	10.2	PRL GNRH1
60	melanotic neurilemmoma	10.2	PRL POMC
61	somatization disorder	10.2	POMC CRH
62	salpingitis isthmica nodosa	10.2	PRL GNRH1
63	sexual health disorder	10.2	PRL GNRH1
64	acute stress disorder	10.2	POMC CRH
65	atypical depressive disorder	10.2	POMC CRH
66	retrograde amnesia	10.2	POMC CRH
67	hypothalamic adipsic hypernatraemia syndrome	10.2
68	sphenoid sinusitis	10.2	POMC AVP
69	hypothyroidism, congenital, nongoitrous, 2	10.2
70	hypothyroidism, congenital, nongoitrous, 3	10.2
71	congenital central hypoventilation syndrome	10.2
72	gaba aminotransferase deficiency	10.2	POMC AVP
73	protein-deficiency anemia	10.2	INS GH1
74	tuberculous epididymitis	10.1	POMC AVP
75	ectopic cushing syndrome	10.1	PRL POMC CRH
76	nelson syndrome	10.1	PRL POMC CRH
77	sexual sadism	10.1	PRL POMC CRH
78	lung oat cell carcinoma	10.1	POMC AVP
79	precocious puberty, male-limited	10.1	POMC GNRH1
80	postpartum depression	10.1	PRL POMC CRH
81	acth-secreting pituitary adenoma	10.1	PRL POMC CRH
82	social phobia	10.1	PRL POMC CRH
83	primary pigmented nodular adrenocortical disease	10.1	PRL POMC CRH
84	euthyroid sick syndrome	10.1	TRH POMC
85	cocaine dependence	10.1	PRL POMC CRH
86	diencephalic astrocytoma	10.1	INS GH1
87	cavernous sinus thrombosis	10.1	POMC INS
88	partial third-nerve palsy	10.1	PRL POMC GH1
89	scleredema adultorum	10.1	POMC INS
90	factitious disorder	10.1	POMC INS
91	malignant olfactory nerve neoplasm	10.1	POMC AVP
92	thyrotropin-releasing hormone deficiency	10.1
93	hirata disease	10.1	POMC INS
94	gynecomastia	10.1	PRL POMC GNRH1
95	hypoglycemic coma	10.1	POMC INS
96	17-beta hydroxysteroid dehydrogenase iii deficiency	10.1	POMC GNRH1 GH1
97	kluver-bucy syndrome	10.1	HCRT CRH
98	cranial nerve malignant neoplasm	10.1	POMC AVP
99	acth-independent macronodular adrenal hyperplasia	10.1	POMC CRH
100	thyroid hormone resistance, selective pituitary	10.1	TSHB TRH
101	phobic disorder	10.1	POMC CRH
102	tuberculum sellae meningioma	10.1	PRL POMC GHRH
103	sella turcica neoplasm	10.1	PRL POMC GHRH
104	endemic goiter	10.1	TSHB TRH
105	pseudohypoparathyroidism, type ia	10.1	POMC GHRH
106	autoimmune polyendocrine syndrome, type ii	10.1	POMC INS
107	barbiturate abuse	10.1	POMC HCRT
108	hydrocephalus	10.1
109	lactocele	10.1	TRH PRL GHRH
110	pancreatic endocrine carcinoma	10.1	POMC INS
111	ovarian cyst	10.1	PRL GNRH1
112	obsessive-compulsive disorder	10.1	PRL POMC CRH
113	isolated growth hormone deficiency, type ib	10.1	GHRH GH1
114	cranial nerve palsy	10.1	PRL POMC AVP
115	paralytic ileus	10.0	INS AVP
116	intracranial hypertension	10.0	PRL POMC AVP
117	tsh producing pituitary tumor	10.0	TSHB PRL POMC
118	supine hypotensive syndrome	10.0	INS AVP
119	dipsogenic diabetes insipidus	10.0	HCRT AVP
120	allan-herndon-dudley syndrome	10.0	TSHB TRH
121	alzheimer disease, familial, 1	10.0
122	central hypoventilation syndrome, congenital, 1	10.0
123	neuroendocrine tumor	10.0
124	ganglioneuroma	10.0
125	growth hormone deficiency	10.0
126	idiopathic hypersomnia	10.0
127	neural crest tumor	10.0
128	hypersomnia	10.0
129	hypothyroidism, central, with testicular enlargement	10.0	TSHB TRH PRL
130	adrenal cortical hypofunction	10.0	POMC INS CRH
131	pain agnosia	10.0	POMC INS CRH
132	agnosia	10.0	POMC INS CRH
133	aspiration pneumonia	10.0	POMC INS
134	cystinosis	10.0	INS GNRH1 GH1
135	thyroid hormone resistance, generalized, autosomal dominant	10.0	TSHB TRH
136	telogen effluvium	10.0	PRL IGF1
137	mental depression	10.0	POMC INS CRH
138	mixed cerebral palsy	10.0	TRH PRL GNRH1 CRH
139	adrenal hypoplasia, congenital	10.0	POMC GNRH1
140	inguinal hernia	10.0	POMC INS GNRH1
141	adrenal carcinoma	10.0	POMC INS CRH
142	van maldergem syndrome 1	10.0	PRL POMC GNRH1 GH1
143	functionless pituitary adenoma	10.0	POMC IGF1
144	graves disease 1	10.0	TRH POMC INS
145	melancholia	10.0	TRH PRL POMC CRH
146	acth deficiency, isolated	10.0	TRH PRL POMC CRH
147	adjustment disorder	10.0	POMC HCRT CRH
148	opiate dependence	10.0	POMC HCRT CRH
149	withdrawal disorder	10.0	POMC HCRT CRH
150	chromophobe adenoma	9.9	TRH PRL POMC GH1
151	gangliocytoma	9.9	PRL POMC GHRH CRH
152	post-traumatic stress disorder	9.9	POMC HCRT CRH
153	carcinoid syndrome	9.9	IGF1 GHRH
154	central pontine myelinolysis	9.9	POMC INS AVP
155	cleft palate, isolated	9.9
156	hypogonadotropic hypogonadism 7 with or without anosmia	9.9
157	pallister-hall syndrome	9.9
158	kleine-levin hibernation syndrome	9.9
159	contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a	9.9
160	hemochromatosis, type 1	9.9
161	pallister-hall-like syndrome	9.9
162	abdominal obesity-metabolic syndrome 1	9.9
163	cranioectodermal dysplasia	9.9
164	congenital generalized lipodystrophy	9.9
165	respiratory failure	9.9
166	familial hyperlipidemia	9.9
167	ganglioneuroblastoma	9.9
168	neuroblastoma	9.9
169	neuromyelitis optica	9.9
170	amyloidosis	9.9
171	diencephalic syndrome	9.9
172	somatostatinoma	9.9	INS GHRH
173	mineral metabolism disease	9.9	POMC INS AVP
174	thyroiditis	9.9	TSHB PRL INS
175	intracranial hypertension, idiopathic	9.9	POMC IGF1
176	retroperitoneal hemangiopericytoma	9.9	INS IGF1
177	pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	9.9	INS IGF1
178	adrenal cortex disease	9.9	PRL POMC INS CRH
179	pituitary adenoma 1, multiple types	9.9	PRL IGF1 GH1
180	steroid inherited metabolic disorder	9.9	PRL POMC INS GNRH1
181	ulcer of lower limbs	9.9	INS IGF1
182	prolactin producing pituitary tumor	9.9	PRL POMC IGF1
183	hypothalamic obesity	9.9
184	potter's syndrome	9.9	INS IGF1
185	central precocious puberty	9.8	POMC IGF1 GNRH1
186	fetal macrosomia	9.8	INS IGF1
187	diffuse idiopathic skeletal hyperostosis	9.8	INS IGF1
188	pseudohypoparathyroidism	9.8	TRH PRL IGF1
189	lissencephaly, x-linked, 2	9.8	PRL IGF1 GHRH
190	kwashiorkor	9.8	INS IGF1
191	multiple endocrine neoplasia, type i	9.8	PRL POMC INS GHRH
192	acquired immunodeficiency syndrome	9.8	POMC IGF1 CRH
193	postpoliomyelitis syndrome	9.8	IGF1 HCRT
194	prostatic hypertrophy	9.8	INS IGF1
195	isolated growth hormone deficiency, type ii	9.8	IGF1 GHRH GH1
196	isolated growth hormone deficiency	9.8	IGF1 GHRH GH1
197	diabetic polyneuropathy	9.8	INS IGF1
198	donohue syndrome	9.8	INS IGF1
199	vipoma	9.8	GHRH GH1
200	substance dependence	9.8	POMC INS CRH AVP
201	alcohol use disorder	9.8	POMC INS CRH AVP
202	hypokalemia	9.8	POMC INS CRH AVP
203	isolated growth hormone deficiency, type ia	9.8	IGF1 GHRH GH1
204	skin atrophy	9.8	POMC IGF1
205	skin tag	9.8	PRL INS IGF1
206	androgenic alopecia	9.8	PRL INS IGF1
207	decubitus ulcer	9.8	INS IGF1
208	angelman syndrome	9.8	POMC INS GNRH1 GHRH
209	cerebral cavernous malformations	9.8
210	optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy	9.8
211	type 2 diabetes mellitus	9.8
212	multiple sclerosis	9.8
213	glioma susceptibility 1	9.8
214	guillain-barre syndrome, familial	9.8
215	huntington disease	9.8
216	hypertriglyceridemia 1	9.8
217	multiple system atrophy 1	9.8
218	lipodystrophy, familial partial, type 2	9.8
219	narcolepsy 1	9.8
220	optic atrophy 1	9.8
221	optic nerve hypoplasia, bilateral	9.8
222	polydactyly, postaxial, type a1	9.8
223	retinoblastoma	9.8
224	strabismus	9.8
225	celiac disease 1	9.8
226	papillon-lefevre syndrome	9.8
227	3-methylglutaconic aciduria, type iii	9.8
228	lipodystrophy, congenital generalized, type 2	9.8
229	mismatch repair cancer syndrome 1	9.8
230	werner syndrome	9.8
231	toe syndactyly, telecanthus, and anogenital and renal malformations	9.8
232	polydactyly	9.8
233	meningioma, familial	9.8
234	lipodystrophy, congenital generalized, type 1	9.8
235	aplastic anemia	9.8
236	myelodysplastic syndrome	9.8
237	leptin receptor deficiency	9.8
238	diffuse large b-cell lymphoma	9.8
239	hyperekplexia	9.8
240	non-alcoholic fatty liver disease	9.8
241	mixed sleep apnea	9.8
242	japanese encephalitis	9.8
243	st. louis encephalitis	9.8
244	pulmonary edema	9.8
245	heart disease	9.8
246	autonomic nervous system disease	9.8
247	visual epilepsy	9.8
248	conjugate gaze palsy	9.8
249	pancytopenia	9.8
250	guillain-barre syndrome	9.8
251	dementia	9.8
252	basilar artery occlusion	9.8
253	toxic shock syndrome	9.8
254	normal pressure hydrocephalus	9.8
255	duodenal ulcer	9.8
256	hyperuricemia	9.8
257	testicular disease	9.8
258	anuria	9.8
259	germinoma	9.8
260	chordoid glioma	9.8
261	hyperglycemia	9.8
262	myopathy	9.8
263	bartter disease	9.8
264	parasagittal meningioma	9.8
265	b-cell lymphoma	9.8
266	peptic ulcer disease	9.8
267	vascular dementia	9.8
268	narcolepsy	9.8
269	central sleep apnea	9.8
270	cleft lip	9.8
271	meningitis	9.8
272	encephalitis	9.8
273	alk-related neuroblastic tumor susceptibility	9.8
274	bap1 tumor predisposition syndrome	9.8
275	isolated gonadotropin-releasing hormone deficiency	9.8
276	autoimmune encephalitis	9.8
277	encephalocele	9.8
278	glioma	9.8
279	primary agammaglobulinemia	9.8
280	pure autonomic failure	9.8
281	tuberculous meningitis	9.8
282	cerebral atrophy	9.8
283	dysautonomia	9.8
284	traumatic brain injury	9.8
285	glial tumor	9.8
286	basal encephalocele	9.8
287	syndromic obesity	9.8
288	genetic obesity	9.8
289	overgrowth syndrome	9.8
290	metabolic myopathy	9.8
291	parathyroid gland disease	9.8	PRL INS IGF1
292	mood disorder	9.8	TRH POMC HCRT CRH
293	fetal alcohol spectrum disorder	9.8	POMC IGF1 AVP
294	mixed cell adenoma	9.8	PRL IGF1 GNRH1 CRH
295	marasmus	9.8	INS IGF1 GH1
296	gilles de la tourette syndrome	9.8
297	oculocerebrocutaneous syndrome	9.8
298	cleft lip/palate	9.8
299	west syndrome	9.8	TRH POMC CRH
300	suprasellar meningioma	9.8	TSHB TRH POMC AVP
301	teeth hard tissue disease	9.7	INS IGF1 GNRH1
302	adermatoglyphia	9.7	INS IGF1 GH1
303	alcohol dependence	9.7	POMC INS CRH AVP
304	acanthosis nigricans	9.7	INS IGF1 GH1
305	pigmentation disease	9.7	POMC INS IGF1
306	restless legs syndrome	9.7	PRL POMC HCRT AVP
307	turner syndrome	9.7	INS IGF1 GH1
308	hair disease	9.7	POMC INS IGF1
309	autoimmune disease of endocrine system	9.7	POMC INS IGF1
310	gestational diabetes	9.7	PRL INS IGF1
311	sarcoidosis 1	9.7
312	arachnoid cysts, intracranial	9.7
313	hydrocephalus due to congenital stenosis of aqueduct of sylvius	9.7
314	body mass index quantitative trait locus 9	9.7
315	body mass index quantitative trait locus 8	9.7
316	body mass index quantitative trait locus 4	9.7
317	body mass index quantitative trait locus 10	9.7
318	body mass index quantitative trait locus 7	9.7
319	body mass index quantitative trait locus 12	9.7
320	sarcoidosis 2	9.7
321	body mass index quantitative trait locus 14	9.7
322	body mass index quantitative trait locus 18	9.7
323	body mass index quantitative trait locus 19	9.7
324	body mass index quantitative trait locus 20	9.7
325	galactorrhoea-hyperprolactinaemia	9.7
326	shapiro syndrome	9.7
327	dysthymic disorder	9.7	POMC INS HCRT CRH
328	nerve compression syndrome	9.7	INS IGF1 GHRH
329	disease of mental health	9.7	POMC INS HCRT CRH
330	fibrous dysplasia	9.7	PRL IGF1 GHRH GH1
331	pituitary hypoplasia	9.7	PRL POMC IGF1 GHRH
332	hormone producing pituitary cancer	9.7	PRL POMC IGF1 GHRH
333	pituitary cancer	9.7	PRL POMC IGF1 GHRH
334	myxedema	9.7	TSHB POMC INS AVP
335	attention deficit-hyperactivity disorder	9.7	POMC INS HCRT CRH
336	pheochromocytoma	9.6	PRL POMC IGF1 CRH
337	uterine benign neoplasm	9.6	PRL INS IGF1 GNRH1
338	reproductive organ benign neoplasm	9.6	PRL INS IGF1 GNRH1
339	amelogenesis imperfecta, type ig	9.6	PRL INS IGF1 GNRH1
340	amelogenesis imperfecta	9.6	PRL INS IGF1 GNRH1
341	persistent fetal circulation syndrome	9.6	POMC INS IGF1 CRH
342	adult syndrome	9.6	POMC INS IGF1 CRH
343	fibromyalgia	9.6	POMC INS IGF1 CRH
344	rasopathy	9.6	INS IGF1 GH1
345	aromatase excess syndrome	9.6	POMC INS IGF1 GNRH1
346	cell type benign neoplasm	9.6	PRL POMC INS IGF1
347	acquired metabolic disease	9.6	PRL POMC INS IGF1
348	goiter	9.6	TRH PRL INS IGF1
349	hyperinsulinism	9.6	INS IGF1 GNRH1 GH1
350	adrenal cortical carcinoma	9.6	POMC INS IGF1 CRH
351	migraine with or without aura 1	9.6	PRL POMC INS HCRT CRH
352	endogenous depression	9.6	TRH PRL POMC INS GNRH1 CRH
353	islet cell tumor	9.5	POMC INS IGF1 GHRH
354	carney complex variant	9.5	PRL POMC IGF1 GHRH CRH
355	growth hormone secreting pituitary adenoma	9.5	PRL POMC IGF1 GHRH GH1
356	deficiency anemia	9.5	INS IGF1 GH1 AVP
357	acne	9.5	PRL POMC INS IGF1 CRH
358	cryptorchidism, unilateral or bilateral	9.5	PRL POMC INS IGF1 GNRH1
359	hypothyroidism, congenital, nongoitrous, 4	9.5	TSHB PRL POMC IGF1 GH1
360	glucose intolerance	9.4	PRL POMC INS IGF1 GH1
361	chronic fatigue syndrome	9.4	POMC INS IGF1 GH1 CRH
362	premature menopause	9.4	PRL POMC INS IGF1 GNRH1
363	acidophil adenoma	9.4	TRH PRL POMC INS IGF1
364	osteoporosis	9.4	PRL INS IGF1 GNRH1 GH1
365	substance abuse	9.3	PRL POMC INS HCRT CRH AVP
366	endocrine organ benign neoplasm	9.3	TRH PRL POMC IGF1 GHRH CRH
367	sebaceous gland disease	9.3	PRL POMC INS IGF1 GNRH1 CRH
368	lipoid congenital adrenal hyperplasia	9.3	PRL POMC INS IGF1 GNRH1 CRH
369	disorder of sexual development	9.3	PRL POMC INS IGF1 GNRH1 GH1
370	eating disorder	9.3	POMC INS IGF1 HCRT CRH
371	specific developmental disorder	9.3	POMC INS IGF1 HCRT CRH
372	hyperthyroidism	9.3	TRH PRL POMC INS IGF1 GH1
373	congenital hypothyroidism	9.2	TSHB TRH PRL IGF1 GHRH GH1
374	thyroid gland disease	9.2	TSHB TRH PRL POMC INS IGF1
375	anxiety	9.2	PRL POMC INS IGF1 HCRT CRH
376	prolactinoma	9.1	TRH PRL POMC INS IGF1 GNRH1
377	schizophrenia	9.1	PRL POMC INS IGF1 HCRT CRH
378	adrenal gland disease	9.1	PRL POMC INS IGF1 GNRH1 CRH
379	diabetes mellitus	9.1	PRL POMC INS IGF1 GH1 CRH
380	hyperpituitarism	8.9	TRH PRL POMC INS IGF1 GHRH
381	functioning pituitary adenoma	8.9	TSHB TRH PRL POMC IGF1 GHRH
382	hypertension, essential	8.9	PRL POMC INS IGF1 HCRT CRH
383	nervous system disease	8.9	PRL POMC INS IGF1 HCRT CRH
384	sheehan syndrome	8.9	TRH PRL POMC INS IGF1 GH1
385	pituitary apoplexy	8.9	TRH PRL POMC INS IGF1 GNRH1
386	pituitary infarct	8.8	TRH PRL POMC INS IGF1 GHRH
387	septooptic dysplasia	8.7	TSHB TRH PRL POMC IGF1 GNRH1

Graphical network of the top 20 diseases related to Hypothalamic Disease:

Sources

Symptoms & Phenotypes for Hypothalamic Disease

MGI Mouse Phenotypes related to Hypothalamic Disease:

⁴⁵ (showing 9, show less)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	10.2	AVP CRH GH1 GHRH GNRH1 HCRT
2	homeostasis/metabolism	MP:0005376	10.06	AVP CRH GH1 GHRH GNRH1 HCRT
3	renal/urinary system	MP:0005367	10.03	AVP CRH GH1 GNRH1 IGF1 INS
4	growth/size/body region	MP:0005378	9.96	CRH GH1 GHRH GNRH1 HCRT IGF1
5	liver/biliary system	MP:0005370	9.95	CRH GH1 GHRH GNRH1 INS POMC
6	adipose tissue	MP:0005375	9.85	CRH GH1 GHRH IGF1 INS POMC
7	endocrine/exocrine gland	MP:0005379	9.81	CRH GH1 GHRH GNRH1 IGF1 INS
8	behavior/neurological	MP:0005386	9.61	AVP CRH GH1 GHRH HCRT INS
9	immune system	MP:0005387	9.28	AVP CRH GH1 GHRH GNRH1 IGF1

Sources

Drugs & Therapeutics for Hypothalamic Disease

Drugs for Hypothalamic Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 25, show less)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Exenatide

Approved, Investigational

Phase 4

141758-74-9

45588096

2

Oxytocin

Approved, Vet_approved

Phase 4

50-56-6

439302 53477758

3

Hydrocortisone succinate

Approved

Phase 4

2203-97-6

3643

4

Hydrocortisone acetate

Approved, Vet_approved

Phase 4

50-03-3

5

Hydrocortisone

Approved, Vet_approved

Phase 4

50-23-7

3640 5754

Synonyms:

(11ALPHA,14BETA)-11,17,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE

(11b)-11,17,21-Trihydroxypregn-4-ene-3,20-dione

(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione

(11Β)-11,17,21-trihydroxypregn-4-ene-3,20-dione

(1S,2R,10S,11S,14S,15S,17S)-14,17-DIHYDROXY-14-(2-HYDROXYACETYL)-2,15-DIMETHYLTETRACYCLO[8.7.0.0^{2,7}.0^{11,15}]HEPTADEC-6-EN-5-ONE

11 Epicortisol

11a-Hydroxycorticosterone

11alpha-Hydroxycorticosterone

11b,17,21-Trihydroxyprogesterone

11b,17a,21-Trihydroxy-4-pregnene-3,20-dione

11beta,17,21-Trihydroxyprogesterone

11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione

11beta-Hydrocortisone

11-beta-Hydrocortisone

11beta-Hydroxycortisone

11-beta-Hydroxycortisone

11b-Hydrocortisone

11b-Hydroxycortisone

11-Epicortisol

11-Hydrocortisone

11Β,17α,21-trihydroxy-4-pregnene-3,20-dione

11Β-hydrocortisone

17a-Hydroxycorticosterone

17alpha-Hydroxycorticosterone

17-Hydroxycorticosterone

4-Pregnen-11b,17a,21-triol-3,20-dione

4-Pregnen-11beta,17alpha,21-triol-3,20-dione

4-Pregnen-11β,17α,21-triol-3,20-dione

4-Pregnene-11alpha,21-triol 3,20-dione

4-Pregnene-11b,17a,21-triol-3,20-dione

ACETASOL HC

ACTICO МИХАИЛRT

Acticort

Acticort®|Efmody®|Plenadren®

Aeroseb HC

Aeroseb-HC

Alacort

Ala-cort

Ala-scalp

Algicirtis

Alphaderm

Amberin

Anflam

Anti-inflammatory hormone

Anucort-HC

ANUGESIC HC

Anusol HC

ANUSOL PLUS HC

ANUSOL SOOTHING RELIEF

Anusol-HC

Aquacort

Aquanil HC

Balneol-HC

Barseb HC

Basan-corti

Beta-HC

b-HC

CaldeCORT spray

CALMURID HC

CANESTEN HC

Cetacort

Chronocort

CIPRO HC

Clear aid

Cleiton

Cobadex

Colocort

Compound F

CORLAN

Cor-oticin

Cortanal

Cor-tar-quin

Cort-dome

Cortef

CORTENEM

Cortenema

Cortesal

Corticreme

Cortifair

Cortifan

Cortifoam

Cortiment

Cortisol

Cortisol alcohol

Cortisolonum

Cortisporin

Cortisporin otico

Cortispray

Cortizol

Cortolotion

Cortonema

Cortoxide

Cort-quin

CORTRIL

Cremesone

Cremicort-H

Cutisol

DAKTACORT

DAKTACORT HYDROCORT

Delacort

DERMA CARE HYDROCORT

Dermacort

Derm-aid

DERMASPRAY DEMANG

Dermil

Dermolate

Dihydrocostisone

Dioderm

Dome-cort

Domolene-HC

Drotic

ECONACORT

Ef corlin

Efcorbin

Efcortelan

EFCORTELAN P

Efcortelin

Eldecort

Eldercort

Epicort

Epicortisol

Epiderm H

Esiderm H

EURAX-HC

EURAX-HYDROCORT

Evacort

EXE-CORT

Ficortril

Fiocortril

Flexicort

Foille insetti

Genacort

GERMOLOIDS HC

Glycort

GREGODERM

gyno-Cortisone

HC

HC #1

HC #4

HC (HYDROCORTISONE)

HC45

H-Cort

Heb cort

Heb-cort

Hi-cor

Hidalone

hidro-Colisona

Hidrocortisona

Hycort

Hycortol

Hycortole

Hydracort

Hydrasson

hydro-Adreson

hydro-Colisona

Hydrocort

HYDROCORT IN CALAMINE OILY

HYDROCORT IN CETOMACROGOL FOR A

HYDROCORT IN WTE SOFT PARAF

Hydrocortal

Hydrocorticosterone

Hydrocortisone

Hydrocortisone acetate

Hydrocortisone alcohol

Hydrocortisone base

Hydrocortisone butyrate

Hydrocortisone free alcohol

Hydrocortisone in absorbase

Hydrocortisone sodium phosphate

Hydrocortisone valerate

Hydrocortisone, (11 alpha)-isomer

Hydrocortisone, (9 beta,10 alpha,11 alpha)-isomer

Hydrocortisonum

Hydrocortistab

Hydrocortisyl

HYDROCORTONE

HYDRODERM

HYDRODERM HC

hydro-RX

Hydroskin

Hydroxycortisone

Hysone

Hytisone

Hytone

Hytone lotion

Idrocortisone

Incortin-H

Incortin-hydrogen

JUNGLE FOR

Kendall's compound F

Komed HC

Kyypakkaus

Lacticare HC

Lacticare-HC

Lactisona

Locoid

Lubricort

Maintasone

Medicort

Meusicort

Micort-HC

Mildison

MILDISON LIPOCREAM

Milliderm

neo-Cort-dome

neo-Cortef

Neosporin-H ear

Nogenic HC

NSC-10483

Nutracort

NYBADEX

Nystaform-HC

Ophthocort

Optef

Otalgine

Otic-neo-cort-dome

Otobiotic

Otocort

OTOSEPTIL

Otosone-F

OTOSPORIN

Pediotic suspension

Penecort

PERINAL

Permicort

Plenadren

Polcort H

Preparation H hydrocortisone cream

Prepcort

Prestwick_265

Prevex HC

Proctocort

PROCTOCREAM HC

Proctofoam

PROCTOFOAM HC

PROCTOSEDYL

Protocort

QUINOCORT

Racet

Rectoid

Reichstein's substance m

Remederm HC

Sanatison

Scalpicin capilar

Schericur

Scheroson F

SENTIAL HC

Sigmacort

Signef

Stie-cort

Stiefcorcil

Synacort

Systral hydrocort

Tarcortin

Terra-cortril

TERRA-CORTRIL NYSTATIN

Texacort

Timocort

TIMODINE

Topicort

TOPISONE

Transderma H

Traumaide

TRI-CICATRIN

U-cort

Uniderm

UNIROID

UNIROID HC

Vioform-hydrocortisone

VoSol HC

Vytone

XYLOPROCT

Zenoxone

β-HC

6

Arginine Vasopressin

Phase 4

7

Hormones

Phase 4

8

Hormone Antagonists

Phase 4

9

Hypoglycemic Agents

Phase 4

10

Glucagon-Like Peptide 1

Phase 4

11

Incretins

Phase 4

12

Anti-Obesity Agents

Phase 4

13

Corticotropin-Releasing Hormone

Phase 4

14

Hydrocortisone 17-butyrate 21-propionate

Phase 4

15

Estradiol

Approved, Investigational, Vet_approved

50-28-2

5757

Synonyms:

(+)-3,17B-ESTRADIOL

(17b)-Estra-1,3,5(10)-triene-3,17-diol

(17BETA)-ESTRA-1,3,5(10)-TRIENE-3,17-DIOL

(17Β)-ESTRA-1,3,5(10)-TRIENE-3,17-DIOL

(1S,10R,11S,14S,15S)-15-METHYLTETRACYCLO[8.7.0.0^{2,7}.0^{11,15}]HEPTADECA-2,4,6-TRIENE-5,14-DIOL

(8R,9S,13S,14S,17S)-13-METHYL-6,7,8,9,11,12,14,15,16,17-DECAHYDROCYCLOPENTA[A]PHENANTHRENE-3,17-DIOL

[3H]-estradiol|[3H]-estrogen|[3H]E2|[3H]estradiol

13B-METHYL-1,3,5(10)-GONATRIENE-3,17B-OL

17 beta Estradiol

17 beta Oestradiol

17 beta-Estradiol

17 beta-Oestradiol

17b Oestradiol

17b-Estra-1,3,5(10)-triene-3,17-diol

17B-ESTRADIOL

17BETA OESTRADIOL

17BETA-ESTRA-1,3,5(10)-TRIENE-3,17-DIOL

17BETA-ESTRADIOL

17BETA-OESTRADIOL

17B-OESTRADIOL

17Β oestradiol

17Β-ESTRA-1,3,5(10)-TRIENE-3,17-DIOL

17β-estradiol

17Β-OESTRADIOL

3,17B-DIHYDROXYESTRA-1,3,5(10)-TRIENE

3,17B-ESTRADIOL

3,17-EPIDIHYDROXYESTRATRIENE

ADGYN ESTRO

AERODIOL

AGOFOLLIN

ALFATRADIOL

ALORA

ALTRAD

AMNESTROGEN

AQUADIOL

AQUAGEN

BARDIOL

BEDOL

B-ESTRADIOL

BETA-ESTRADIOL

CIS-ESTRADIOL

CLIMADERM

CLIMARA

CLIMARA PRO

COMPUDOSE

CORPAGEN

Delestrogen

DELTA-ESTRADIOL

DELTA-OESTRADIOL

DEPO-ESTRADIOL

DERMESTRIL

DERMESTRIL 100

DERMESTRIL 25

DERMESTRIL 50

DERMESTRIL SEPTEM 25

DERMESTRIL SEPTEM 50

DERMESTRIL SEPTEM 75

DESTRADIOL

D-ESTRADIOL

DIHYDROFOLLICULAR HORMONE

DIHYDROFOLLICULIN

DIHYDROMENFORMON

DIHYDROTHEELIN

DIHYDRO-THEELIN

DIHYDROXYESTRIN

DIMENFORMON

DIOGYN

DIOGYNETS

DIVIGEL

D-OESTRADIOL

E2

E2|estrogen|oestrodiol|oestrogen

E-CYPIONATE

ELESTRIM

ELESTRIN

ELLESTE SOLO

ELLESTE SOLO MX 40

ELLESTE SOLO MX 80

ENCORE

EPIESTRIOL 50

ESCLIM

ESTRA-1,3,5(10)-TRIENE-3,17B-DIOL

ESTRACE

ESTRADERM

ESTRADERM MX 100

ESTRADERM MX 25

ESTRADERM MX 50

ESTRADERM MX 75

ESTRADERM TTS

ESTRADERM TTS 100

ESTRADERM TTS 25

ESTRADERM TTS 50

ESTRADIOL

Estradiol 17 alpha

Estradiol 17 beta

Estradiol 17beta

Estradiol anhydrous

ESTRADIOL HEMIHYDRATE

Estradiol hemihydrate, (17 alpha)-isomer

Estradiol monohydrate

Estradiol orion brand

Estradiol valerate

Estradiol valeriante

Estradiol, (-)-isomer

Estradiol, (+-)-isomer

Estradiol, (16 alpha,17 alpha)-isomer

Estradiol, (16 alpha,17 beta)-isomer

Estradiol, (17-alpha)-isomer

Estradiol, (8 alpha,17 beta)-(+-)-isomer

Estradiol, (8 alpha,17 beta)-isomer

Estradiol, (9 beta,17 alpha)-isomer

Estradiol, (9 beta,17 beta)-isomer

Estradiol, monosodium salt

Estradiol, sodium salt

Estradiol-17 alpha

Estradiol-17 beta

Estradiol-17b

ESTRADIOL-17BETA

ESTRADIOL-17-BETA

Estradiol-17β

ESTRADIOLUM

ESTRADOT

ESTRALDINE

ESTRASORB

ESTRING

ESTRING VAGINAL RING

ESTROCLIM

ESTROCLIM 50

ESTROGEL

ESTROGEL HBF

ESTROGEN

ESTROVITE

EVAMIST

EVOREL

EVOREL 100

EVOREL 25

EVOREL 50

EVOREL 75

FEMATRIX 40

FEMATRIX 80

FEMESTRAL

FEMOGEN

FEMPATCH

FEMSEVEN 100

FEMSEVEN 50

FEMSEVEN 75

FOLLICYCLIN

GELESTRA

GINOSEDOL

GVNODIOL

GYNERGON

GYNODIOL

GYNOESTRYL

GYNOGEN

IMVEXXY

INNOFEM

LAMDIOL

MACRODIOL

MENOREST

MENOREST 37.5

MENOREST 50

MENOREST 75

MENORING 50

MENOSTAR

MINIVELLE

NORDICOL

Novartis pharmaceuticals brand OF estradiol

NSC-20293

NSC-9895

OESCLIM

OESTERGON

OESTRA-1,3,5(10)-TRIENE-3,17B-DIOL

OESTRADIOL

OESTRODIOL

OESTROGEL

OESTROGEN

OESTROGLANDOL

Orion brand OF estradiol

OVAHORMON

OVASTEROL

OVASTEVOL

OVOCYCLIN

OVOCYLIN

PERLATANOL

PRIMOFOL

PROFOLIOL

PROFOLIOL B

PROGYNON

Progynon depot

PROGYNON DH

Progynon-depot

Progynova

PROGYNOVA TS

SANDRENA

SANDRENA 1

SYNDIOL

SYSTEN

VAGIFEM

VAGIFEM 18

VAGIFEM 8

VIVELLE

VIVELLE-DOT

WC3011

WC-3011

ZUMENON

Β-estradiol

16

Polyestradiol phosphate

Approved

28014-46-2

17

Lenograstim

Approved, Investigational

135968-09-1

18

Cyclophosphamide

Approved, Investigational

50-18-0, 6055-19-2

2907

19

Estradiol 3-benzoate

20

Estradiol 17 beta-cypionate

21

Alkylating Agents

22

Antirheumatic Agents

23

Antineoplastic Agents, Alkylating

24

Immunosuppressive Agents

25

Immunologic Factors

Interventional clinical trials:

(showing 5, show less)

#	Name	Status	NCT ID	Phase	Drugs
1	Identification and Clinical Relevance of an Oxytocin Deficient State: a Randomized, Crossover, Placebo-controlled, Proof-of-concept, Physiopathological Study (GLP1 Study)	Recruiting	NCT04897802	Phase 4	Experimental: GLP1-RA (exenatide) administration;Control: Placebo administration
2	Identification and Clinical Relevance of an Oxytocin Deficient State: a Randomized, Crossover, Placebo-controlled, Proof-of-concept Physiopathological Study (CRH Study)	Recruiting	NCT04902235	Phase 4	Experimental: CRH administration;Control: Placebo administration
3	The Physiological Changes in Reproductive Hormones During Sustained Administration of Kisspeptin in Humans.	Unknown status	NCT02081924
4	International Rapid-onset Obesity With Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD) REDCap Registry	Recruiting	NCT03135730
5	High-dose Cyclophosphamide for the Treatment of ROHHAD (Rapid Onset Obesity, Hypoventilation, Hypothalamic Dysfunction, and Autonomic Dysregulation) Syndrome	Active, not recruiting	NCT02441491		Cyclophosphamide

Search NIH Clinical Center for Hypothalamic Disease

Cochrane evidence based reviews: hypothalamic diseases

Sources

Genetic Tests for Hypothalamic Disease

Sources

Anatomical Context for Hypothalamic Disease

Organs/tissues related to Hypothalamic Disease:

MalaCards : Hypothalamus, Pituitary, Testes, Thyroid, Occipital Lobe, Brain, Ovary

Sources

Publications for Hypothalamic Disease

Articles related to Hypothalamic Disease:

(showing 172, show less)

#	Title	Authors	PMID	Year
1	Growth hormone replacement inhibits renal and hepatic 11 beta-hydroxysteroid dehydrogenases in ACTH-deficient patients. ⁵³ ⁶²	Walker BR...Padfield PL	9828916	1998
2	Dynamics of prolactin secretion in patients with hypopituitarism and pituitary macroadenomas. ⁵³ ⁶²	Arafah BM...Selman WR	8530591	1995
3	[Disturbance of hypothalamic-pituitary hormone secretion in familial chorea-acanthocytosis]. ⁵³ ⁶²	Terao S...Sakakibara T	7669403	1995
4	Pathogenesis of pituitary Cushing's syndrome. Pituitary versus hypothalamic. ⁵³ ⁶²	Biller BM	7805653	1994
5	An apparent cluster of congenital hypopituitarism in central Massachusetts: magnetic resonance imaging and hormonal studies. ⁵³ ⁶²	Brown RS...Hayes E	1846002	1991
6	CRH and lysine-vasopressin stimulation tests in the diagnosis of hypoadrenalism secondary to hypothalamic or pituitary disorders. ⁵³ ⁶²	Cantalamessa L...Peracchi G	2169450	1990
7	What Works for One May Not Work for Another: A New Warning for Modafinil. ⁶²	Kim H...Scharf SM	36043022	2022
8	Autoimmunity Related to Adipsic Hypernatremia and ROHHAD Syndrome. ⁶²	Nakamura-Utsunomiya A	35805903	2022
9	A new perspective of hypothalamic disease: Shapiro's syndrome. ⁶²	Ren L...Wang G	35968294	2022
10	Bexarotene-induced central hypothyroidism assessed by TRH stimulation test in cutaneous T-cell lymphoma patients. ⁶²	Toi N...Emoto M	34433736	2022
11	European guideline and expert statements on the management of narcolepsy in adults and children. ⁶²	Bassetti CLA...Lammers GJ	34173288	2021
12	European guideline and expert statements on the management of narcolepsy in adults and children. ⁶²	Bassetti CLA...Lammers GJ	34173695	2021
13	Effects of Childhood Multidisciplinary Care and Growth Hormone Treatment on Health Problems in Adults with Prader-Willi Syndrome. ⁶²	Pellikaan K...de Graaff LCG	34362034	2021
14	Biochemical transition during triphasic postpartum thyroiditis: confusion with central hypothyroidism. ⁶²	Oyibo SO...Sagi SV	34280894	2021
15	Multidisciplinary Approach for Hypothalamic Obesity in Children and Adolescents: A Preliminary Study. ⁶²	Tessaris D...de Sanctis L	34206290	2021
16	Case Report: A Rare Case of Coexisting of Autoimmune Polyglandular Syndrome Type 3 and Isolated Gonadotropin-Releasing Hormone Deficiency. ⁶²	Jiang Q...Li X	34594339	2021
17	"Non-Classical" Indication for Provocative Testing of Growth Hormone: A Retrospective Cohort Study in Adult Patients Under Replacement Therapy. ⁶²	Mancini A...Pontecorvi A	32990548	2021
18	Missed Diagnoses and Health Problems in Adults With Prader-Willi Syndrome: Recommendations for Screening and Treatment. ⁶²	Pellikaan K...de Graaff LCG	32877518	2020
19	Conventional autoantibodies against brain antigens are not routinely detectable in serum and CSF of narcolepsy type 1 and 2 patients. ⁶²	Dietmann A...Bassetti CLA	32858359	2020
20	Testosterone Supplementation Rescues Spermatogenesis and In Vitro Fertilizing Ability of Sperm in Kiss1 Knockout Mice. ⁶²	Goto T...Uenoyama Y	32514526	2020
21	Sarcoidosis and the Nervous System. ⁶²	Pawate S	32487903	2020
22	Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment. ⁶²	Bassetti CLA...Dauvilliers Y	31324898	2019
23	Management of hypothalamic disease in patients with craniopharyngioma. ⁶²	Thompson CJ...Crowley RK	30614015	2019
24	Adipsic Diabetes Insipidus-The Challenging Combination of Polyuria and Adipsia: A Case Report and Review of Literature. ⁶²	Dalan R...Chua KS	31620086	2019
25	A hotspots analysis-relation discovery representation model for revealing diabetes mellitus and obesity. ⁶²	He G...Guan R	30547805	2018
26	Reference intervals for thyrotropin in an area of Northern Italy: the Pordenone thyroid study (TRIPP). ⁶²	Tozzoli R...Bagnasco M	29340973	2018
27	Hypothermia in Multiple Sclerosis: Beyond the Hypothalamus? A Case Report and Review of the Literature. ⁶²	Berti F...Gran B	29755800	2018
28	Pediatric Adrenal Insufficiency: Diagnosis, Management, and New Therapies. ⁶²	Bowden SA...Henry R	30515225	2018
29	[The hypothalamus in Huntington's disease]. ⁶²	Bellosta-Diago E...Lopez Del Val LJ	29071701	2017
30	Diabetes insipidus and hypopituitarism in HIV: an unexpected cause. ⁶²	Tavares Bello C...Vasconcelos C	28620498	2017
31	Central hypothyroidism and its role for cardiovascular risk factors in hypopituitary patients. ⁶²	Feldt-Rasmussen U...Klose M	27481361	2016
32	[Addison's disease : Primary adrenal insufficiency]. ⁶²	Pulzer A...Hahner S	27129928	2016
33	The Evaluation of Adrenal Function in Two Cases of Hypocortisolism Accompanied by Liver Cirrhosis. ⁶²	Yamashita M...Daimon M	27041161	2016
34	Paraneoplastic limbic encephalitis with associated hypothalamitis mimicking a hyperdense hypothalamic tumor: a case report. ⁶²	Bataduwaarachchi VR...Tissera N	26782815	2016
35	Management of Craniopharyngioma - Perspectives beyond Surgery and Endocrinology. ⁶²	Crowley RK...Thompson CJ	29632577	2015
36	Oral manifestations of hypothyroidism: a case report. ⁶²	Gupta R...Gupta S	24995258	2014
37	Psychotropic-induced hyperprolactinemia: a clinical review. ⁶²	Ajmal A...Nachtigall LB	24140188	2014
38	Comparison of body composition, basal metabolic rate and metabolic outcomes of adults with Prader Willi syndrome or lesional hypothalamic disease, with primary obesity. ⁶²	Lloret-Linares C...Poitou C	23318724	2013
39	GLP-1 analogues as a new treatment option for hypothalamic obesity in adults: report of nine cases. ⁶²	Zoicas F...Schofl C	23392214	2013
40	Hypothalamic germinoma masquerading as superior mesenteric artery (SMA) syndrome. ⁶²	Vethakkan SR...Choong K	23186972	2013
41	Development and validation of a new questionnaire assessing quality of life in adults with hypopituitarism: Adult Hypopituitarism Questionnaire (AHQ). ⁶²	Ishii H...Chihara K	22984490	2012
42	Management of subclinical hyperthyroidism. ⁶²	Santos Palacios S...Galofre JC	23843809	2012
43	Partial hypopituitarism and Langerhans cell histiocytosis. ⁶²	Balaguruswamy S...Chattington PD	22715201	2011
44	Disorder in the serotonergic system due to tryptophan hydroxylation impairment: a cause of hypothalamic syndrome? ⁶²	Schott DA...Gerver WJ	20190542	2010
45	Slow-growing craniopharyngioma masquarading as early-onset eating disorder: two cases. ⁶²	Vad Winkler L...Stoving RK	19115368	2009
46	[Visual pathway and pituitary stalk protection in pituitary tumor surgery and the clinical outcome]. ⁶²	Gong SP...Yang QY	19246307	2009
47	Clinical perspectives on the genetics of schizophrenia: a bottom-up orientation. ⁶²	Verhoeven WM...Tuinier S	19073422	2008
48	Androgens may mediate a relative preservation of IGF-I levels in overweight and obese women despite reduced growth hormone secretion. ⁶²	Utz AL...Miller KK	18647804	2008
49	Diagnostic usefulness of the growth hormone-releasing peptide-2 test as a substitute for the insulin tolerance test in hypopituitarism. ⁶²	Kageyama K...Suda T	18493103	2008
50	Growth hormone deficiency by growth hormone releasing hormone-arginine testing criteria predicts increased cardiovascular risk markers in normal young overweight and obese women. ⁶²	Utz AL...Miller KK	18445664	2008
51	Use of somatostatin analogues in obesity. ⁶²	Tzotzas T...Krassas GE	18778119	2008
52	Prader-Willi syndrome: atypical psychoses and motor dysfunctions. ⁶²	Verhoeven WM...Tuinier S	16697294	2006
53	Hypopituitarism. ⁶²	Ascoli P...Cavagnini F	17077946	2006
54	Neurocognitive function in adults with growth hormone deficiency. ⁶²	van Dam PS	16439853	2005
55	Effects of medications on regulation of body temperature of patients with Tourette syndrome. ⁶²	Kessler AR	15119484	2004
56	Is the thyrotropin-releasing hormone test necessary in the diagnosis of central hypothyroidism in children. ⁶²	Mehta A...Dattani MT	14671155	2003
57	Tourette syndrome associated with body temperature dysregulation: possible involvement of an idiopathic hypothalamic disorder. ⁶²	Kessler AR	12546427	2002
58	Osteopenic mice: animal models of the aging skeleton. ⁶²	Priemel M...Amling M	15758436	2002
59	Diagnosis and management of growth hormone deficiency in adults. ⁶²	Stavrou S...Kleinberg DL	11571930	2001
60	Serum thyroid-stimulating hormone measurement for assessment of thyroid function and disease. ⁶²	Ross DS	11444162	2001
61	Basal, pulsatile, entropic, and 24-hour rhythmic features of secondary hyperprolactinemia due to functional pituitary stalk disconnection mimic tumoral (primary) hyperprolactinemia. ⁶²	Veldman RG...Roelfsema F	11297584	2001
62	Central control of bone formation. ⁶²	Takeda S...Karsenty G	11368306	2001
63	Pituitary-thyroid feedback hypersensitivity as a novel cause of hypothyroidism in children. ⁶²	Frankton S...Williams GR	11072946	2000
64	Experience with cyproterone acetate in the treatment of precocious puberty. ⁶²	Laron Z...Kauli R	10969925	2000
65	Clinical diagnosis of hyper- and hypocortisolism. ⁶²	Oelkers W	12689470	2000
66	An 11-year-old girl with syndrome of inappropriate antidiuretic hormone secretion. ⁶²	Breningstall GN	10522340	1999
67	Kleine-Levin and Munchausen syndromes in a patient with recurrent acromegaly. ⁶²	Jungheim K...Usadel KH	10069657	1999
68	Pulsatile GnRH or human chorionic gonadotropin/human menopausal gonadotropin as effective treatment for men with hypogonadotropic hypogonadism: a review of 42 cases. ⁵³	Buchter D...Nieschlag E	9758439	1998
69	One century after the description of the "sign": Joseph Babinski and his contribution to neurosurgery. ⁶²	Lanzino G...Laws ER	9092856	1997
70	Clinical review 86: Euthyroid sick syndrome: is it a misnomer? ⁶²	Chopra IJ	9024211	1997
71	Obese (ob) gene defects are rare in human obesity. ⁶²	Carlsson B...Carlsson LM	9061713	1997
72	Hypothalamic disease: neurosecretory dysfunction and parasellar lesions. ⁶²	Bercu BB	9174692	1997
73	Hyperprolactinemia. ⁶²	Kaye TB	29224529	1996
74	A comparison between short ACTH and insulin stress tests for assessing hypothalamo-pituitary-adrenal function. ⁶²	Ammari F...Scanion MF	8706316	1996
75	Endocrine abnormalities in hemodialysis patients with iron overload: reversal with iron depletion. ⁶²	el-Reshaid K...Kamel H	8748213	1995
76	Primary Amenorrhea and Persistent Stress Fracture. ⁶²	Roberts WO	29272181	1995
77	High efficacy of gonadotropin or pulsatile gonadotropin-releasing hormone treatment in hypogonadotropic hypogonadal men. ⁵³	Kliesch S...Nieschlag E	7921222	1994
78	[A case of dural type of histiocytosis X presenting as a mass lesion in the tentorium cerebelli]. ⁶²	Baba T...Hashi K	8196835	1994
79	Brain tumors and anorexia nervosa syndrome. ⁶²	Chipkevitch E	7943600	1994
80	Anophthalmia, cleft lip/palate, facial anomalies, and CNS anomalies and hypothalamic disorder in a newborn: a midline developmental field defect. ⁶²	Leichtman LG...Rohn R	8160751	1994
81	Chronic hypothermia and water intoxication associated with a neurodegenerative disease. ⁶²	Corbett EL...Sarkar D	8121871	1993
82	Plasma levels of corticotropin-releasing hormone in hypothalamic-pituitary-adrenal disorders and chronic renal failure. ⁵³	Hashimoto K...Suemaru S	8393256	1993
83	The neuropsychiatry of chronic fatigue syndrome. ⁶²	Wessely S	8491099	1993
84	[Metabolic effects of obesity in men]. ⁶²	Vermeulen A	8128779	1993
85	Corticotropin-releasing hormone and adrenocorticotropic hormone concentrations in cerebrospinal fluid of dogs with pituitary-dependent hyperadrenocorticism. ⁶²	Van Wijk PA...Mol JA	1332844	1992
86	Diencephalic idiopathic gliosis: an unusual hypothalamic syndrome of dermopathy, diarrhea and growth arrest. ⁶²	Espiner E...Bergeron C	1430843	1992
87	Hypothalamic failure as a sequela of heterozygous protein C deficiency? ⁶²	Schmitt S...Kiess W	1628670	1992
88	Neurologic manifestations of hypothalamic disease. ⁶²	Martin JB...Riskind PN	1480755	1992
89	Variable hormonogenesis in Cushing's syndrome. ⁶²	Shapiro MS...Shenkman L	1649480	1991
90	Hypogonadism of male prolactinomas: relation to pulsatile secretion of LH. ⁶²	Saitoh Y...Mogami H	2099670	1990
91	Dopamine-mediated effects induced by metoclopramide simultaneously on adrenocorticotropic hormone and prolactin in patients with pituitary and/or hypothalamic disorders. ⁵³	Nishida S...Ishii R	2174755	1990
92	Very-low-calorie diet-induced weight reduction reverses impaired growth hormone secretion response to growth hormone-releasing hormone, arginine, and L-dopa in obesity. ⁶²	Tanaka K...Takamura Y	2118219	1990
93	Induction of ovulation with pulsatile gonadotropin releasing hormone (GnRH) in anovulatory women. ⁵³	Cignitti M...Romanini C	2132474	1990
94	The use and limitations of a chemiluminescent thyrotropin assay as a single thyroid function test in an out-patient endocrine clinic. ⁶²	Ross DS...Gouveia D	2394778	1990
95	[A case of recessive dystrophic epidermolysis bullosa associated with dwarfism with special reference to pathophysiological role of growth hormone]. ⁶²	Nakamura F...Yoshikawa K	2332081	1990
96	[Prader-Willi-Labhart syndrome: relations with the hypothalamus and chromosome 15]. ⁶²	Touraine P...Chretien M	2130760	1990
97	[Acute hemorrhage and ischemic necroses in hypophyseal tumors: hypophyseal apoplexy]. ⁶²	Seyer H...Fahlbusch R	2599499	1989
98	[Kleine-Levin syndrome. The provocation of manic symptoms by an antidepressant and a therapeutic trial of carbamazepine]. ⁶²	Wurthmann C...Gerhardt P	2791906	1989
99	Volume homeostasis and osmoregulation in human pregnancy. ⁶²	Davison JM...Lindheimer MD	2698144	1989
100	Hypothalamic disease in association with dysgenesis of the corpus callosum. ⁶²	Page SR...Johnson DA	2813236	1989
101	Hypothalamic-pituitary dysfunction in polycystic ovarian disease. ⁶²	Adashi EY	3143565	1988
102	Altered pulsatile pattern of luteinizing hormone in men with idiopathic normogonadotropic oligospermia. ⁶²	Levalle OA...Guitelman A	3135207	1988
103	Primary histiocytosis X of the parieto-occipital lobe. ⁶²	Eriksen B...DalCanto MC	3259535	1988
104	Hypercortisolism in patients with functional hypothalamic-amenorrhea. ⁶²	Suh BY...Yen SS	3346352	1988
105	Epidemiology of infertility and polycystic ovarian disease: endocrinological and demographic studies. ⁶²	Hull MG	3140583	1987
106	Symptomatic hypothalamic-pituitary dysfunction in nasopharyngeal carcinoma patients following radiation therapy: a retrospective study. ⁶²	Lam KS...Yeung RT	3624043	1987
107	Neuroendocrine syndromes of the hypothalamus. ⁶²	Abrams GM...Schipper HM	3540584	1986
108	Hypothalamic dysfunction following whole-brain irradiation. ⁶²	Mechanick JI...LaRocque A	3760958	1986
109	Late recurrence of surgically removed prolactinomas. ⁶²	Parl FF...Aleshire SL	3697940	1986
110	Growth hormone response to low dose intravenous injections of growth hormone releasing factor in obese and normal weight women. ⁶²	Kopelman PG...Noonan K	2871950	1986
111	Hypothalamic disease presenting as amenorrhoea: value of computed tomography. ⁶²	Ferrari C...Crosignani PG	4084469	1985
112	Comparison of insulin hypoglycemia and short metyrapone tests in patients with pituitary disease. ⁶²	Achenbach K...Oelkers W	3900556	1985
113	Impaired growth hormone response to growth hormone releasing factor and insulin-hypoglycaemia in obesity. ⁶²	Kopelman PG...Forrest AJ	2863016	1985
114	Plasma growth hormone response to synthetic GH-RH1-44 in 52 children and adults with growth hormone deficiency of various etiologies. ⁶²	Pertzelan A...Laron Z	3928474	1985
115	Isolated follicle-stimulating hormone deficiency in men: successful long-term gonadotropin therapy. ⁶²	Al-Ansari AA...Mortimer CH	6436064	1984
116	[Psychological characteristics of women with postpartum hypothalamic disorder]. ⁶²	Motyka M	6500400	1984
117	Effects of human pancreatic tumour growth hormone releasing factor on growth hormone and somatomedin C levels in patients with idiopathic growth hormone deficiency. ⁶²	Borges JL...Thorner MO	6134978	1983
118	Primary empty sella, hyperprolactinemia, and isolated ACTH deficiency after postpartum hemorrhage. ⁶²	Stacpoole PW...Fisher WR	6301277	1983
119	The Prader-Willi syndrome: neuroendocrine study of identical twins. ⁶²	Trevisan C...Mantero F	6683267	1983
120	Response to TRH in suspected hypopituitarism. ⁶²	Milner RD...Herber SM	6404226	1983
121	Prolactin response to the dopamine antagonists sulpiride and domperidone. Further evidence for pituitary dopamine deficiency in hyperprolactinemic disorders of different etiology. ⁶²	Ferrari C...Crosignani PG	6642291	1983
122	A comparison of pituitary cells from lean and obese Zucker Rats. ⁶²	Martin RJ...Hymer W	6828456	1983
123	Functional characterization of hypothalamic hyperprolactinemia. ⁶²	Ferrari C...Crosignani PG	6811605	1982
124	[Pharmacological studies in hypothalamic disorder-induced obesity in mice. Effect of anti-inflammatory and analgesic agents on hypothalamic disorder-induced obesity in mice]. ⁶²	Ishii N	6821303	1982
125	Gonadotropin responsiveness to luteinizing hormone releasing hormone in prepubertal and pubertal patients with growth hormone deficiency. ⁶²	Frisch H...Schernthaner G	6814178	1982
126	The response of prolactin to chlorpromazine stimulation in men with hypogonadotrophic hypogonadism and early pubertal boys: relationship to sex steroid exposure. ⁶²	Winters SJ...Sherins RJ	6807580	1982
127	Postcraniotomy diabetes insipidus. Who's at risk? ⁶²	Balestrieri FJ...Rainey TG	7060374	1982
128	Plasma prolactin and gonadotrophins in anorexia nervosa and amenorrhoea due to weight loss. ⁶²	Skrabanek P...Powell D	6791425	1981
129	Evidence for the hypothalamic origin of the polycystic ovary syndrome. ⁶²	Wortsman J...Murphy J	6454866	1981
130	Studies of hypothalamic function in Huntington's chorea. ⁶²	Lavin PJ...Sheridan P	6455503	1981
131	Sexual and hypothalamic dysfunction in the postconcussional syndrome. ⁶²	Kosteljanetz M...Johnsen SG	6782821	1981
132	Hypernatraemia, diabetes mellitus, hyperprolactinaemia, retarded growth and delayed puberty in a 14 year old girl. Effect of bromocriptine treatment. ⁶²	Christensen NC...Petersen S	7006294	1981
133	Hyperprolactinemia in chronic renal failure: impaired responsiveness to stimulation and suppression. Normalization after transplantation. ⁶²	Peces R...Hernando L	6791043	1981
134	Synthesis of DNA in oestrogen-induced pituitary tumurs in rats: effect of bromocriptine. ⁶²	Kalbermann LE...Burdman JA	7430920	1980
135	Increased slow wave sleep in a hypopituitary dwarf. ⁶²	Tormey WP...Darragh AS	7393788	1980
136	Repetitive infusion of gonadotropin-releasing hormone distinguishes hypothalamic from pituitary hypogonadism. ⁶²	Snyder PJ...Rothman JG	372209	1979
137	Prolactin levels and bromocriptine treatment of short luteal phase. ⁶²	Lehtovirta P...Seppala M	37181	1979
138	[Hypothalamic control of TSH secretion. Current methods of exploration and perspectives for the future]. ⁶²	Mornex R...Jordan D	159769	1979
139	Epileptic laughter with precocious puberty. ⁶²	Williams M...Savage D	747405	1978
140	Endocrine evaluation of the infertile male. ⁶²	Snyder PJ	734814	1978
141	Plasma TSH and prolactin response to insulin induced hypoglycemia in patients with hypothalamic pituitary disorders. ⁶²	Demura R...Shizume K	710372	1978
142	[The neurophysins (author's transl)]. ⁶²	Legros JJ	736518	1978
143	The secretion of thyrotrophin with impaired biological activity in patients with hypothalamic-pituitary disease. ⁶²	Petersen VB...Hall R	647990	1978
144	Sexual precocity in association with septo-optic dysplasia and hypothalamic hypopituitarism. ⁶²	Huseman CA...Zipf WB	205644	1978
145	Hypothalamic hypothyroidism causing spastic paraplegia: recovery following thyroid medication. ⁶²	Jackson IM...Kassirer M	727728	1978
146	Cushing's syndrome associated with galactorrhea, amenorrhea, and hypothyroidism: a primary hypothalamic disorder. ⁶²	Berlinger FG...Wilber JF	591615	1977
147	Radiological aspects of pituitary--hypothalamic disease. ⁶²	Doyle F...McLachlan M	330035	1977
148	Correlation between integrated LH and FSH levels and the response to luteinizing hormone relasing factor (LRF). ⁶²	Mortimer RH...Freeman RG	794076	1976
149	Adrenal function in the diabetic mutant mouse (gene symbol dbm). ⁶²	Naeser P	998290	1976
150	Diagnosis of radiosensitive hypothalamic tumors without craniotomy: endocrine and neuroradiologic studies of intracranial atypical teratomas. ⁶²	Spiegel AM...Pomeroy TC	786092	1976
151	The effects of clomiphene citrate on the hypothalamic-pituitary-gonadal axis in anorexia nervosa. ⁶²	Wakeling A...Russell GF	996198	1976
152	Pregnancy following 2-bromo-alpha-ergocryptine (CB-154)-induced ovulation in an acromegalic patient with galactorrhea and amenorrhea. ⁶²	Aono T...Kurachi K	943332	1976
153	FSH and LH response to LHRF in Kallman's syndrome. ⁶²	Oettinger M...Greenblatt RB	765905	1976
154	Some aspects of hypothalamic-pituitary function in patients with anorexia nervosa. ⁶²	Travaglini P...Faglia G	813472	1976
155	Periodic apnea, exercise hypoventilation, and hypothalamic dysfunction. ⁶²	Moskowitz MA...Strieder DJ	1252044	1976
156	Hyperprolactinemia in sarcoidosis: incidence and utility in predicting hypothalamic involvement. ⁶²	Munt PW...Underwood LE	1171648	1975
157	Effect of synthetic gonadotropin-releasing hormone (GnRH) in a patient with the "fertile eunuch" syndrome. ⁶²	Williams C...Hallberg MC	1097462	1975
158	The pituitary-adrenal system of the genetically obese (ob/ob) mouse. ⁶²	Edwardson JA...Hough CA	167093	1975
159	In vitro testing of thyroid function: a review. ⁶²	Pain RW	806877	1975
160	Evidence that acromegaly is not a hypothalamic disease. ⁶²	Allen JP...Castro A	4363384	1973
161	[Clinico-neuroendocrinological study of diencephalon-hypophysis diseases. 3. Patterns and endocrinological findings in hypothalamic disorder]. ⁶²	Sakota M...Oishi H	5466327	1970
162	A comparative study of endocrine tests in hypothalamic disease. Circadian periodicity of plasma 11-OHCS levels, plama 11-OHCS and growth hormone response to insulin hypoglycemia and metyrapone responsiveness. ⁶²	Krieger DT...Krieger HP	5697039	1968
163	[Paroxysmal atrial tachycardia in the course of chronic multisymptomatic hypothalamic disease]. ⁶²	Petelenz T...Buczkowski M	6063355	1967
164	Evaluation of ACTH reserve in pituitary-hypothalamic disease. ⁶²	De Witt GF...Selby R	4288690	1966
165	Probable Hypothalamic Disorder Requiring Corticoid Therapy in Patients with Pituitary Adenoma or Craniopharyngioma. ⁶²	Morse WI	20327312	1962
166	Dysrhythmia associated with proved hypothalamic disease. Fourteen- and six-per-second dysrhythmia. ⁶²	LITTLE SC...BEVILACQUA AR	14465902	1962
167	[Clinical data on hypothalamic disease]. ⁶²	SZOBOR A	13774634	1960
168	[Testicular insufficiency in the adult caused by hypothalamic disorder; report on 2 clinical cases]. ⁶²	PITIS M...TEODORESCU E	13538018	1958
169	Premature pubarche; a hypothalamic disorder? Report of 17 cases. ⁶²	THAMDRUP E	14375676	1955
170	Endocrine and other clinical manifestations of hypothalamic disease; a survey of 60 cases, with autopsies. ⁶²	BAUER HG	13130650	1954
171	Homicide as a manifestation of thalamic or hypothalamic disorder with abnormal electroencephalographic findings. ⁶²	SCHWADE ED...OTTO O	13039293	1953
172	Matricide with electroencephalographic evidence of thalamic or hypothalamic disorder. ⁶²	SCHWADE ED...GEIGER SG	13020966	1953

Sources

Genes for Hypothalamic Disease

Genes related to Hypothalamic Disease (0 elite genes):

(showing 12, show less)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	PRL	Prolactin	Protein Coding	13.25	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	8530591 2174755 7669403 (more) 1846002
2	CRH	Corticotropin Releasing Hormone	Protein Coding	13.06	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	8393256 7805653 2169450
3	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	11.68	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	9758439 7921222 2132474
4	GH1	Growth Hormone 1	Protein Coding	11.44	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	9828916
5	POMC	Proopiomelanocortin	Protein Coding	6.59	DISEASES inferred ¹⁴
6	TRH	Thyrotropin Releasing Hormone	Protein Coding	6.54	DISEASES inferred ¹⁴
7	GHRH	Growth Hormone Releasing Hormone	Protein Coding	6.17	DISEASES inferred ¹⁴
8	AVP	Arginine Vasopressin	Protein Coding	5.58	DISEASES inferred ¹⁴
9	INS	Insulin	Protein Coding	5.56	DISEASES inferred ¹⁴
10	HCRT	Hypocretin Neuropeptide Precursor	Protein Coding	5.28	DISEASES inferred ¹⁴
11	IGF1	Insulin Like Growth Factor 1	Protein Coding	5.23	DISEASES inferred ¹⁴
12	TSHB	Thyroid Stimulating Hormone Subunit Beta	Protein Coding	5.1	DISEASES inferred ¹⁴

Sources

Variations for Hypothalamic Disease

Sources

Expression for Hypothalamic Disease

Search GEO for disease gene expression data for Hypothalamic Disease.

Sources

Pathways for Hypothalamic Disease

Pathways related to Hypothalamic Disease according to GeneCards Suite gene sharing:

(showing 21, show less)

#	Super pathways	Score	Top Affiliating Genes
1	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.28	PRL INS IGF1 GNRH1 GHRH GH1
2	GPCR downstream signalling ⁶⁶ Show member pathways G alpha (i) signalling events ⁶⁶ G alpha (q) signalling events ⁶⁶ Signaling by GPCR ⁶⁶	13.28	TSHB TRH POMC HCRT GNRH1 GHRH
3	Class A/1 (Rhodopsin-like receptors) ⁶⁶ Show member pathways GPCR ligand binding ⁶⁶ GPCRs, class A rhodopsin-like ⁷⁴ Peptide GPCRs ⁷⁴ Peptide ligand-binding receptors ⁶⁶	12.99	AVP CRH GHRH GNRH1 HCRT POMC
4	p70S6K Signaling ⁶⁴ Show member pathways mTOR Pathway ⁶⁴ Renin-Angiotensin Pathway ⁶⁴	12.78	INS IGF1 GNRH1 GHRH GH1
5	Signal Transduction ⁶⁶	12.74	TSHB TRH POMC INS IGF1 HCRT
6	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.46	IGF1 GNRH1 GHRH GH1
7	G-Beta Gamma Signaling ⁶⁴ Show member pathways CRHR Pathway ⁶⁴ GHRH Signaling ⁶⁴	12.41	POMC GHRH GH1 CRH
8	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.4	IGF1 GNRH1 GHRH GH1
9	G-protein signaling RAC1 in cellular process ²² Show member pathways CDC42 signaling events ⁶¹ Cytoskeleton remodeling CDC42 in cellular processes ²² RAC1 signaling pathway ⁶¹	12.14	IGF1 GNRH1 GHRH GH1
10	Adipogenesis ⁷⁴	11.84	GH1 IGF1 INS
11	Peptide hormone metabolism ⁶⁶ Show member pathways Glycoprotein hormones ⁶⁶ Metabolism of Angiotensinogen to Angiotensins ⁶⁶ Metabolism of Angiotensinogen to Angiotensins ⁷⁴ Peptide hormone biosynthesis ⁶⁶ Synthesis, secretion, and deacylation of Ghrelin ⁶⁶ thyroid hormone biosynthesis ⁶¹	11.78	TSHB POMC INS IGF1 GH1
12	G alpha (s) signalling events ⁶⁶ Show member pathways Defective ACTH causes obesity and POMCD ⁶⁶	11.56	TSHB POMC GHRH CRH AVP
13	Thyroid hormones production and peripheral downstream signaling effects ⁷⁴	11.55	POMC TRH TSHB
14	G-protein signaling_RhoA regulation pathway ²²	11.47	IGF1 GNRH1 GHRH GH1
15	Prader-Willi and Angelman syndrome ⁷⁴	11.4	POMC INS GNRH1 GHRH
16	Development_Leptin signaling via JAK/STAT and MAPK cascades ²² Show member pathways phospho-PLA2 pathway ⁶⁶	11.07	TRH POMC
17	Serotonin and anxiety ⁷⁴ Show member pathways Serotonin and anxiety-related events ⁷⁴	11.05	POMC CRH
18	Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics ⁶⁰	10.85	PRL POMC INS
19	G-protein signaling_Rap2B regulation pathway ²²	10.78	IGF1 GNRH1 GHRH GH1
20	Hormone ligand-binding receptors ⁶⁶	10.59	TSHB GNRH1
21	Glucocorticoid Pathway (HPA Axis), Pharmacodynamics ⁶⁰	10.28	POMC CRH

Sources

GO Terms for Hypothalamic Disease

Cellular components related to Hypothalamic Disease according to GeneCards Suite gene sharing:

(showing 4, show less)

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.96	AVP CRH GH1 GHRH GNRH1 IGF1
2	secretory granule	GO:0030141	9.86	TRH POMC HCRT AVP
3	extracellular region	GO:0005576	9.7	TSHB TRH PRL POMC INS IGF1
4	endosome lumen	GO:0031904	9.63	PRL INS GH1

Biological processes related to Hypothalamic Disease according to GeneCards Suite gene sharing:

(showing 7, show less)

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	10.03	AVP CRH GH1 GNRH1 IGF1 INS
2	positive regulation of cell population proliferation	GO:0008284	10.02	PRL INS IGF1 GHRH AVP
3	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	9.85	INS IGF1 GH1
4	positive regulation of glycogen biosynthetic process	GO:0045725	9.71	INS IGF1
5	negative regulation of transmission of nerve impulse	GO:0051970	9.56	HCRT AVP
6	cell-cell signaling	GO:0007267	9.47	TSHB TRH POMC INS GNRH1 GHRH
7	positive regulation of insulin-like growth factor receptor signaling pathway	GO:0043568	9.43	IGF1 GHRH GH1

Molecular functions related to Hypothalamic Disease according to GeneCards Suite gene sharing:

(showing 4, show less)

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:0005179	9.6	TSHB TRH PRL POMC INS IGF1
2	insulin-like growth factor receptor binding	GO:0005159	9.56	INS IGF1
3	neuropeptide hormone activity	GO:0005184	9.56	HCRT GHRH CRH AVP
4	prolactin receptor binding	GO:0005148	9.46	PRL GH1

Sources

Sources for Hypothalamic Disease

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

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¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: HYP085 MIFTS: 40	Hypothalamic Disease Categories: Endocrine diseases, Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
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