MCID: HYP085
MIFTS: 40

Hypothalamic Disease

Categories: Endocrine diseases, Neuronal diseases
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Aliases & Classifications for Hypothalamic Disease

MalaCards integrated aliases for Hypothalamic Disease:

Name: Hypothalamic Disease 11 14 75
Hypothalamic Diseases 43 71
Hypothalamic Dysfunction Syndromes 71
Hypothalamic Dysfunction 75
Hypothalamic Disorder 53

Classifications:



External Ids:

Disease Ontology 11 DOID:1931
MeSH 43 D007027
SNOMED-CT 68 88108008
ICD10 31 E23.3
UMLS 71 C0020655 C0751230

Summaries for Hypothalamic Disease

MalaCards based summary: Hypothalamic Disease, also known as hypothalamic diseases, is related to precocious puberty and diabetes insipidus, neurohypophyseal. An important gene associated with Hypothalamic Disease is PRL (Prolactin), and among its related pathways/superpathways are TGF-Beta Pathway and GPCR downstream signalling. The drugs Exenatide and Oxytocin have been mentioned in the context of this disorder. Affiliated tissues include hypothalamus, pituitary and testes, and related phenotypes are nervous system and homeostasis/metabolism

Wikipedia: 75 Hypothalamic disease is a disorder presenting primarily in the hypothalamus, which may be caused by... more...

Related Diseases for Hypothalamic Disease

Diseases related to Hypothalamic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 387, show less)
# Related Disease Score Top Affiliating Genes
1 precocious puberty 30.5 GNRH1 GH1
2 diabetes insipidus, neurohypophyseal 30.3 POMC AVP
3 premature ovarian failure 7 30.1 POMC GH1 CRH
4 hypothyroidism, congenital, nongoitrous, 1 30.0 TSHB GHRH
5 diabetes insipidus 29.7 PRL POMC INS GH1 CRH AVP
6 neurotic disorder 29.7 POMC INS CRH
7 galactorrhea 29.7 PRL IGF1
8 inappropriate adh syndrome 29.5 PRL POMC CRH AVP
9 pituitary tumors 29.4 PRL IGF1 GH1
10 hypogonadism 29.3 PRL POMC INS IGF1 GNRH1 GH1
11 panic disorder 29.3 TRH PRL POMC GHRH CRH
12 sleep apnea 29.2 INS IGF1 HCRT
13 prediabetes syndrome 29.2 INS IGF1 GH1
14 central diabetes insipidus 29.2 TRH PRL POMC IGF1 GNRH1 GH1
15 overnutrition 29.1 POMC INS IGF1
16 hypogonadotropic hypogonadism 29.1 PRL POMC INS IGF1 GNRH1
17 pituitary-dependent cushing's disease 29.1 TRH PRL POMC GHRH GH1 CRH
18 apnea, obstructive sleep 29.0 POMC INS IGF1 HCRT
19 amenorrhea 28.9 TRH PRL POMC INS IGF1 GNRH1
20 mccune-albright syndrome 28.9 PRL POMC IGF1 GHRH GH1
21 anovulation 28.9 PRL INS IGF1 GNRH1 CRH
22 craniopharyngioma 28.9 TRH PRL INS IGF1 GNRH1 GH1
23 polycystic ovary syndrome 28.8 PRL POMC INS IGF1 GNRH1 GH1
24 ovarian disease 28.8 PRL POMC INS IGF1 GNRH1
25 insulin-like growth factor i 28.8 PRL INS IGF1 GHRH GH1
26 hyperandrogenism 28.6 PRL POMC INS IGF1 GNRH1 GH1
27 leptin deficiency or dysfunction 28.5 TRH POMC INS IGF1 HCRT GNRH1
28 sleep disorder 28.5 POMC INS IGF1 HCRT CRH
29 major depressive disorder 28.4 TRH PRL POMC INS HCRT CRH
30 anorexia nervosa 28.4 PRL POMC INS IGF1 HCRT GHRH
31 empty sella syndrome 28.3 TRH PRL POMC INS IGF1 GNRH1
32 hypopituitarism 28.3 TRH PRL POMC INS IGF1 GNRH1
33 hypothyroidism 28.2 TSHB TRH PRL POMC INS IGF1
34 hypoglycemia 28.2 TRH PRL POMC INS IGF1 GHRH
35 adenoma 28.0 TSHB TRH PRL POMC IGF1 GHRH
36 hyperprolactinemia 27.9 TRH PRL POMC INS IGF1 GNRH1
37 pituitary hormone deficiency, combined, 2 27.8 TSHB TRH PRL POMC IGF1 GNRH1
38 pituitary adenoma 27.7 TSHB TRH PRL POMC IGF1 GNRH1
39 acromegaly 27.7 TRH PRL POMC INS IGF1 GNRH1
40 pituitary gland disease 27.7 TSHB TRH PRL POMC INS IGF1
41 conn's syndrome 27.5 TRH PRL POMC INS IGF1 GNRH1
42 prader-willi syndrome 27.4 TRH PRL POMC INS IGF1 HCRT
43 body mass index quantitative trait locus 11 27.2 TRH PRL POMC INS IGF1 HCRT
44 rohhad 11.6
45 rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome 11.6
46 fryns microphthalmia syndrome 11.1
47 froelich syndrome 10.9
48 leydig cell hypoplasia type ii 10.3 PRL GNRH1
49 pyometritis 10.3 PRL GNRH1
50 chiasmal syndrome 10.3 PRL POMC
51 polyp of corpus uteri 10.3 PRL GNRH1
52 rete ovarii adenoma 10.3 PRL GNRH1
53 rete ovarii benign neoplasm 10.3 PRL GNRH1
54 waterhouse-friderichsen syndrome 10.3 POMC CRH
55 mediastinal lipomatosis 10.3 POMC CRH
56 submucous uterine fibroid 10.3 PRL GNRH1
57 premenstrual tension 10.2 POMC GNRH1
58 abducens palsy 10.2 PRL POMC
59 estrogen excess 10.2 PRL GNRH1
60 melanotic neurilemmoma 10.2 PRL POMC
61 somatization disorder 10.2 POMC CRH
62 salpingitis isthmica nodosa 10.2 PRL GNRH1
63 sexual health disorder 10.2 PRL GNRH1
64 acute stress disorder 10.2 POMC CRH
65 atypical depressive disorder 10.2 POMC CRH
66 retrograde amnesia 10.2 POMC CRH
67 hypothalamic adipsic hypernatraemia syndrome 10.2
68 sphenoid sinusitis 10.2 POMC AVP
69 hypothyroidism, congenital, nongoitrous, 2 10.2
70 hypothyroidism, congenital, nongoitrous, 3 10.2
71 congenital central hypoventilation syndrome 10.2
72 gaba aminotransferase deficiency 10.2 POMC AVP
73 protein-deficiency anemia 10.2 INS GH1
74 tuberculous epididymitis 10.1 POMC AVP
75 ectopic cushing syndrome 10.1 PRL POMC CRH
76 nelson syndrome 10.1 PRL POMC CRH
77 sexual sadism 10.1 PRL POMC CRH
78 lung oat cell carcinoma 10.1 POMC AVP
79 precocious puberty, male-limited 10.1 POMC GNRH1
80 postpartum depression 10.1 PRL POMC CRH
81 acth-secreting pituitary adenoma 10.1 PRL POMC CRH
82 social phobia 10.1 PRL POMC CRH
83 primary pigmented nodular adrenocortical disease 10.1 PRL POMC CRH
84 euthyroid sick syndrome 10.1 TRH POMC
85 cocaine dependence 10.1 PRL POMC CRH
86 diencephalic astrocytoma 10.1 INS GH1
87 cavernous sinus thrombosis 10.1 POMC INS
88 partial third-nerve palsy 10.1 PRL POMC GH1
89 scleredema adultorum 10.1 POMC INS
90 factitious disorder 10.1 POMC INS
91 malignant olfactory nerve neoplasm 10.1 POMC AVP
92 thyrotropin-releasing hormone deficiency 10.1
93 hirata disease 10.1 POMC INS
94 gynecomastia 10.1 PRL POMC GNRH1
95 hypoglycemic coma 10.1 POMC INS
96 17-beta hydroxysteroid dehydrogenase iii deficiency 10.1 POMC GNRH1 GH1
97 kluver-bucy syndrome 10.1 HCRT CRH
98 cranial nerve malignant neoplasm 10.1 POMC AVP
99 acth-independent macronodular adrenal hyperplasia 10.1 POMC CRH
100 thyroid hormone resistance, selective pituitary 10.1 TSHB TRH
101 phobic disorder 10.1 POMC CRH
102 tuberculum sellae meningioma 10.1 PRL POMC GHRH
103 sella turcica neoplasm 10.1 PRL POMC GHRH
104 endemic goiter 10.1 TSHB TRH
105 pseudohypoparathyroidism, type ia 10.1 POMC GHRH
106 autoimmune polyendocrine syndrome, type ii 10.1 POMC INS
107 barbiturate abuse 10.1 POMC HCRT
108 hydrocephalus 10.1
109 lactocele 10.1 TRH PRL GHRH
110 pancreatic endocrine carcinoma 10.1 POMC INS
111 ovarian cyst 10.1 PRL GNRH1
112 obsessive-compulsive disorder 10.1 PRL POMC CRH
113 isolated growth hormone deficiency, type ib 10.1 GHRH GH1
114 cranial nerve palsy 10.1 PRL POMC AVP
115 paralytic ileus 10.0 INS AVP
116 intracranial hypertension 10.0 PRL POMC AVP
117 tsh producing pituitary tumor 10.0 TSHB PRL POMC
118 supine hypotensive syndrome 10.0 INS AVP
119 dipsogenic diabetes insipidus 10.0 HCRT AVP
120 allan-herndon-dudley syndrome 10.0 TSHB TRH
121 alzheimer disease, familial, 1 10.0
122 central hypoventilation syndrome, congenital, 1 10.0
123 neuroendocrine tumor 10.0
124 ganglioneuroma 10.0
125 growth hormone deficiency 10.0
126 idiopathic hypersomnia 10.0
127 neural crest tumor 10.0
128 hypersomnia 10.0
129 hypothyroidism, central, with testicular enlargement 10.0 TSHB TRH PRL
130 adrenal cortical hypofunction 10.0 POMC INS CRH
131 pain agnosia 10.0 POMC INS CRH
132 agnosia 10.0 POMC INS CRH
133 aspiration pneumonia 10.0 POMC INS
134 cystinosis 10.0 INS GNRH1 GH1
135 thyroid hormone resistance, generalized, autosomal dominant 10.0 TSHB TRH
136 telogen effluvium 10.0 PRL IGF1
137 mental depression 10.0 POMC INS CRH
138 mixed cerebral palsy 10.0 TRH PRL GNRH1 CRH
139 adrenal hypoplasia, congenital 10.0 POMC GNRH1
140 inguinal hernia 10.0 POMC INS GNRH1
141 adrenal carcinoma 10.0 POMC INS CRH
142 van maldergem syndrome 1 10.0 PRL POMC GNRH1 GH1
143 functionless pituitary adenoma 10.0 POMC IGF1
144 graves disease 1 10.0 TRH POMC INS
145 melancholia 10.0 TRH PRL POMC CRH
146 acth deficiency, isolated 10.0 TRH PRL POMC CRH
147 adjustment disorder 10.0 POMC HCRT CRH
148 opiate dependence 10.0 POMC HCRT CRH
149 withdrawal disorder 10.0 POMC HCRT CRH
150 chromophobe adenoma 9.9 TRH PRL POMC GH1
151 gangliocytoma 9.9 PRL POMC GHRH CRH
152 post-traumatic stress disorder 9.9 POMC HCRT CRH
153 carcinoid syndrome 9.9 IGF1 GHRH
154 central pontine myelinolysis 9.9 POMC INS AVP
155 cleft palate, isolated 9.9
156 hypogonadotropic hypogonadism 7 with or without anosmia 9.9
157 pallister-hall syndrome 9.9
158 kleine-levin hibernation syndrome 9.9
159 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 9.9
160 hemochromatosis, type 1 9.9
161 pallister-hall-like syndrome 9.9
162 abdominal obesity-metabolic syndrome 1 9.9
163 cranioectodermal dysplasia 9.9
164 congenital generalized lipodystrophy 9.9
165 respiratory failure 9.9
166 familial hyperlipidemia 9.9
167 ganglioneuroblastoma 9.9
168 neuroblastoma 9.9
169 neuromyelitis optica 9.9
170 amyloidosis 9.9
171 diencephalic syndrome 9.9
172 somatostatinoma 9.9 INS GHRH
173 mineral metabolism disease 9.9 POMC INS AVP
174 thyroiditis 9.9 TSHB PRL INS
175 intracranial hypertension, idiopathic 9.9 POMC IGF1
176 retroperitoneal hemangiopericytoma 9.9 INS IGF1
177 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 9.9 INS IGF1
178 adrenal cortex disease 9.9 PRL POMC INS CRH
179 pituitary adenoma 1, multiple types 9.9 PRL IGF1 GH1
180 steroid inherited metabolic disorder 9.9 PRL POMC INS GNRH1
181 ulcer of lower limbs 9.9 INS IGF1
182 prolactin producing pituitary tumor 9.9 PRL POMC IGF1
183 hypothalamic obesity 9.9
184 potter's syndrome 9.9 INS IGF1
185 central precocious puberty 9.8 POMC IGF1 GNRH1
186 fetal macrosomia 9.8 INS IGF1
187 diffuse idiopathic skeletal hyperostosis 9.8 INS IGF1
188 pseudohypoparathyroidism 9.8 TRH PRL IGF1
189 lissencephaly, x-linked, 2 9.8 PRL IGF1 GHRH
190 kwashiorkor 9.8 INS IGF1
191 multiple endocrine neoplasia, type i 9.8 PRL POMC INS GHRH
192 acquired immunodeficiency syndrome 9.8 POMC IGF1 CRH
193 postpoliomyelitis syndrome 9.8 IGF1 HCRT
194 prostatic hypertrophy 9.8 INS IGF1
195 isolated growth hormone deficiency, type ii 9.8 IGF1 GHRH GH1
196 isolated growth hormone deficiency 9.8 IGF1 GHRH GH1
197 diabetic polyneuropathy 9.8 INS IGF1
198 donohue syndrome 9.8 INS IGF1
199 vipoma 9.8 GHRH GH1
200 substance dependence 9.8 POMC INS CRH AVP
201 alcohol use disorder 9.8 POMC INS CRH AVP
202 hypokalemia 9.8 POMC INS CRH AVP
203 isolated growth hormone deficiency, type ia 9.8 IGF1 GHRH GH1
204 skin atrophy 9.8 POMC IGF1
205 skin tag 9.8 PRL INS IGF1
206 androgenic alopecia 9.8 PRL INS IGF1
207 decubitus ulcer 9.8 INS IGF1
208 angelman syndrome 9.8 POMC INS GNRH1 GHRH
209 cerebral cavernous malformations 9.8
210 optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy 9.8
211 type 2 diabetes mellitus 9.8
212 multiple sclerosis 9.8
213 glioma susceptibility 1 9.8
214 guillain-barre syndrome, familial 9.8
215 huntington disease 9.8
216 hypertriglyceridemia 1 9.8
217 multiple system atrophy 1 9.8
218 lipodystrophy, familial partial, type 2 9.8
219 narcolepsy 1 9.8
220 optic atrophy 1 9.8
221 optic nerve hypoplasia, bilateral 9.8
222 polydactyly, postaxial, type a1 9.8
223 retinoblastoma 9.8
224 strabismus 9.8
225 celiac disease 1 9.8
226 papillon-lefevre syndrome 9.8
227 3-methylglutaconic aciduria, type iii 9.8
228 lipodystrophy, congenital generalized, type 2 9.8
229 mismatch repair cancer syndrome 1 9.8
230 werner syndrome 9.8
231 toe syndactyly, telecanthus, and anogenital and renal malformations 9.8
232 polydactyly 9.8
233 meningioma, familial 9.8
234 lipodystrophy, congenital generalized, type 1 9.8
235 aplastic anemia 9.8
236 myelodysplastic syndrome 9.8
237 leptin receptor deficiency 9.8
238 diffuse large b-cell lymphoma 9.8
239 hyperekplexia 9.8
240 non-alcoholic fatty liver disease 9.8
241 mixed sleep apnea 9.8
242 japanese encephalitis 9.8
243 st. louis encephalitis 9.8
244 pulmonary edema 9.8
245 heart disease 9.8
246 autonomic nervous system disease 9.8
247 visual epilepsy 9.8
248 conjugate gaze palsy 9.8
249 pancytopenia 9.8
250 guillain-barre syndrome 9.8
251 dementia 9.8
252 basilar artery occlusion 9.8
253 toxic shock syndrome 9.8
254 normal pressure hydrocephalus 9.8
255 duodenal ulcer 9.8
256 hyperuricemia 9.8
257 testicular disease 9.8
258 anuria 9.8
259 germinoma 9.8
260 chordoid glioma 9.8
261 hyperglycemia 9.8
262 myopathy 9.8
263 bartter disease 9.8
264 parasagittal meningioma 9.8
265 b-cell lymphoma 9.8
266 peptic ulcer disease 9.8
267 vascular dementia 9.8
268 narcolepsy 9.8
269 central sleep apnea 9.8
270 cleft lip 9.8
271 meningitis 9.8
272 encephalitis 9.8
273 alk-related neuroblastic tumor susceptibility 9.8
274 bap1 tumor predisposition syndrome 9.8
275 isolated gonadotropin-releasing hormone deficiency 9.8
276 autoimmune encephalitis 9.8
277 encephalocele 9.8
278 glioma 9.8
279 primary agammaglobulinemia 9.8
280 pure autonomic failure 9.8
281 tuberculous meningitis 9.8
282 cerebral atrophy 9.8
283 dysautonomia 9.8
284 traumatic brain injury 9.8
285 glial tumor 9.8
286 basal encephalocele 9.8
287 syndromic obesity 9.8
288 genetic obesity 9.8
289 overgrowth syndrome 9.8
290 metabolic myopathy 9.8
291 parathyroid gland disease 9.8 PRL INS IGF1
292 mood disorder 9.8 TRH POMC HCRT CRH
293 fetal alcohol spectrum disorder 9.8 POMC IGF1 AVP
294 mixed cell adenoma 9.8 PRL IGF1 GNRH1 CRH
295 marasmus 9.8 INS IGF1 GH1
296 gilles de la tourette syndrome 9.8
297 oculocerebrocutaneous syndrome 9.8
298 cleft lip/palate 9.8
299 west syndrome 9.8 TRH POMC CRH
300 suprasellar meningioma 9.8 TSHB TRH POMC AVP
301 teeth hard tissue disease 9.7 INS IGF1 GNRH1
302 adermatoglyphia 9.7 INS IGF1 GH1
303 alcohol dependence 9.7 POMC INS CRH AVP
304 acanthosis nigricans 9.7 INS IGF1 GH1
305 pigmentation disease 9.7 POMC INS IGF1
306 restless legs syndrome 9.7 PRL POMC HCRT AVP
307 turner syndrome 9.7 INS IGF1 GH1
308 hair disease 9.7 POMC INS IGF1
309 autoimmune disease of endocrine system 9.7 POMC INS IGF1
310 gestational diabetes 9.7 PRL INS IGF1
311 sarcoidosis 1 9.7
312 arachnoid cysts, intracranial 9.7
313 hydrocephalus due to congenital stenosis of aqueduct of sylvius 9.7
314 body mass index quantitative trait locus 9 9.7
315 body mass index quantitative trait locus 8 9.7
316 body mass index quantitative trait locus 4 9.7
317 body mass index quantitative trait locus 10 9.7
318 body mass index quantitative trait locus 7 9.7
319 body mass index quantitative trait locus 12 9.7
320 sarcoidosis 2 9.7
321 body mass index quantitative trait locus 14 9.7
322 body mass index quantitative trait locus 18 9.7
323 body mass index quantitative trait locus 19 9.7
324 body mass index quantitative trait locus 20 9.7
325 galactorrhoea-hyperprolactinaemia 9.7
326 shapiro syndrome 9.7
327 dysthymic disorder 9.7 POMC INS HCRT CRH
328 nerve compression syndrome 9.7 INS IGF1 GHRH
329 disease of mental health 9.7 POMC INS HCRT CRH
330 fibrous dysplasia 9.7 PRL IGF1 GHRH GH1
331 pituitary hypoplasia 9.7 PRL POMC IGF1 GHRH
332 hormone producing pituitary cancer 9.7 PRL POMC IGF1 GHRH
333 pituitary cancer 9.7 PRL POMC IGF1 GHRH
334 myxedema 9.7 TSHB POMC INS AVP
335 attention deficit-hyperactivity disorder 9.7 POMC INS HCRT CRH
336 pheochromocytoma 9.6 PRL POMC IGF1 CRH
337 uterine benign neoplasm 9.6 PRL INS IGF1 GNRH1
338 reproductive organ benign neoplasm 9.6 PRL INS IGF1 GNRH1
339 amelogenesis imperfecta, type ig 9.6 PRL INS IGF1 GNRH1
340 amelogenesis imperfecta 9.6 PRL INS IGF1 GNRH1
341 persistent fetal circulation syndrome 9.6 POMC INS IGF1 CRH
342 adult syndrome 9.6 POMC INS IGF1 CRH
343 fibromyalgia 9.6 POMC INS IGF1 CRH
344 rasopathy 9.6 INS IGF1 GH1
345 aromatase excess syndrome 9.6 POMC INS IGF1 GNRH1
346 cell type benign neoplasm 9.6 PRL POMC INS IGF1
347 acquired metabolic disease 9.6 PRL POMC INS IGF1
348 goiter 9.6 TRH PRL INS IGF1
349 hyperinsulinism 9.6 INS IGF1 GNRH1 GH1
350 adrenal cortical carcinoma 9.6 POMC INS IGF1 CRH
351 migraine with or without aura 1 9.6 PRL POMC INS HCRT CRH
352 endogenous depression 9.6 TRH PRL POMC INS GNRH1 CRH
353 islet cell tumor 9.5 POMC INS IGF1 GHRH
354 carney complex variant 9.5 PRL POMC IGF1 GHRH CRH
355 growth hormone secreting pituitary adenoma 9.5 PRL POMC IGF1 GHRH GH1
356 deficiency anemia 9.5 INS IGF1 GH1 AVP
357 acne 9.5 PRL POMC INS IGF1 CRH
358 cryptorchidism, unilateral or bilateral 9.5 PRL POMC INS IGF1 GNRH1
359 hypothyroidism, congenital, nongoitrous, 4 9.5 TSHB PRL POMC IGF1 GH1
360 glucose intolerance 9.4 PRL POMC INS IGF1 GH1
361 chronic fatigue syndrome 9.4 POMC INS IGF1 GH1 CRH
362 premature menopause 9.4 PRL POMC INS IGF1 GNRH1
363 acidophil adenoma 9.4 TRH PRL POMC INS IGF1
364 osteoporosis 9.4 PRL INS IGF1 GNRH1 GH1
365 substance abuse 9.3 PRL POMC INS HCRT CRH AVP
366 endocrine organ benign neoplasm 9.3 TRH PRL POMC IGF1 GHRH CRH
367 sebaceous gland disease 9.3 PRL POMC INS IGF1 GNRH1 CRH
368 lipoid congenital adrenal hyperplasia 9.3 PRL POMC INS IGF1 GNRH1 CRH
369 disorder of sexual development 9.3 PRL POMC INS IGF1 GNRH1 GH1
370 eating disorder 9.3 POMC INS IGF1 HCRT CRH
371 specific developmental disorder 9.3 POMC INS IGF1 HCRT CRH
372 hyperthyroidism 9.3 TRH PRL POMC INS IGF1 GH1
373 congenital hypothyroidism 9.2 TSHB TRH PRL IGF1 GHRH GH1
374 thyroid gland disease 9.2 TSHB TRH PRL POMC INS IGF1
375 anxiety 9.2 PRL POMC INS IGF1 HCRT CRH
376 prolactinoma 9.1 TRH PRL POMC INS IGF1 GNRH1
377 schizophrenia 9.1 PRL POMC INS IGF1 HCRT CRH
378 adrenal gland disease 9.1 PRL POMC INS IGF1 GNRH1 CRH
379 diabetes mellitus 9.1 PRL POMC INS IGF1 GH1 CRH
380 hyperpituitarism 8.9 TRH PRL POMC INS IGF1 GHRH
381 functioning pituitary adenoma 8.9 TSHB TRH PRL POMC IGF1 GHRH
382 hypertension, essential 8.9 PRL POMC INS IGF1 HCRT CRH
383 nervous system disease 8.9 PRL POMC INS IGF1 HCRT CRH
384 sheehan syndrome 8.9 TRH PRL POMC INS IGF1 GH1
385 pituitary apoplexy 8.9 TRH PRL POMC INS IGF1 GNRH1
386 pituitary infarct 8.8 TRH PRL POMC INS IGF1 GHRH
387 septooptic dysplasia 8.7 TSHB TRH PRL POMC IGF1 GNRH1

Graphical network of the top 20 diseases related to Hypothalamic Disease:



Diseases related to Hypothalamic Disease

Symptoms & Phenotypes for Hypothalamic Disease

MGI Mouse Phenotypes related to Hypothalamic Disease:

45 (showing 9, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.2 AVP CRH GH1 GHRH GNRH1 HCRT
2 homeostasis/metabolism MP:0005376 10.06 AVP CRH GH1 GHRH GNRH1 HCRT
3 renal/urinary system MP:0005367 10.03 AVP CRH GH1 GNRH1 IGF1 INS
4 growth/size/body region MP:0005378 9.96 CRH GH1 GHRH GNRH1 HCRT IGF1
5 liver/biliary system MP:0005370 9.95 CRH GH1 GHRH GNRH1 INS POMC
6 adipose tissue MP:0005375 9.85 CRH GH1 GHRH IGF1 INS POMC
7 endocrine/exocrine gland MP:0005379 9.81 CRH GH1 GHRH GNRH1 IGF1 INS
8 behavior/neurological MP:0005386 9.61 AVP CRH GH1 GHRH HCRT INS
9 immune system MP:0005387 9.28 AVP CRH GH1 GHRH GNRH1 IGF1

Drugs & Therapeutics for Hypothalamic Disease

Drugs for Hypothalamic Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 25, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Exenatide Approved, Investigational Phase 4 141758-74-9 45588096
2
Oxytocin Approved, Vet_approved Phase 4 50-56-6 439302 53477758
3
Hydrocortisone succinate Approved Phase 4 2203-97-6 3643
4
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
5
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 3640 5754
6 Arginine Vasopressin Phase 4
7 Hormones Phase 4
8 Hormone Antagonists Phase 4
9 Hypoglycemic Agents Phase 4
10 Glucagon-Like Peptide 1 Phase 4
11 Incretins Phase 4
12 Anti-Obesity Agents Phase 4
13 Corticotropin-Releasing Hormone Phase 4
14 Hydrocortisone 17-butyrate 21-propionate Phase 4
15
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
16
Polyestradiol phosphate Approved 28014-46-2
17
Lenograstim Approved, Investigational 135968-09-1
18
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
19 Estradiol 3-benzoate
20 Estradiol 17 beta-cypionate
21 Alkylating Agents
22 Antirheumatic Agents
23 Antineoplastic Agents, Alkylating
24 Immunosuppressive Agents
25 Immunologic Factors

Interventional clinical trials:

(showing 5, show less)
# Name Status NCT ID Phase Drugs
1 Identification and Clinical Relevance of an Oxytocin Deficient State: a Randomized, Crossover, Placebo-controlled, Proof-of-concept, Physiopathological Study (GLP1 Study) Recruiting NCT04897802 Phase 4 Experimental: GLP1-RA (exenatide) administration;Control: Placebo administration
2 Identification and Clinical Relevance of an Oxytocin Deficient State: a Randomized, Crossover, Placebo-controlled, Proof-of-concept Physiopathological Study (CRH Study) Recruiting NCT04902235 Phase 4 Experimental: CRH administration;Control: Placebo administration
3 The Physiological Changes in Reproductive Hormones During Sustained Administration of Kisspeptin in Humans. Unknown status NCT02081924
4 International Rapid-onset Obesity With Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD) REDCap Registry Recruiting NCT03135730
5 High-dose Cyclophosphamide for the Treatment of ROHHAD (Rapid Onset Obesity, Hypoventilation, Hypothalamic Dysfunction, and Autonomic Dysregulation) Syndrome Active, not recruiting NCT02441491 Cyclophosphamide

Search NIH Clinical Center for Hypothalamic Disease

Cochrane evidence based reviews: hypothalamic diseases

Genetic Tests for Hypothalamic Disease

Anatomical Context for Hypothalamic Disease

Organs/tissues related to Hypothalamic Disease:

MalaCards : Hypothalamus, Pituitary, Testes, Thyroid, Occipital Lobe, Brain, Ovary

Publications for Hypothalamic Disease

Articles related to Hypothalamic Disease:

(showing 172, show less)
# Title Authors PMID Year
1
Growth hormone replacement inhibits renal and hepatic 11 beta-hydroxysteroid dehydrogenases in ACTH-deficient patients. 53 62
9828916 1998
2
Dynamics of prolactin secretion in patients with hypopituitarism and pituitary macroadenomas. 53 62
8530591 1995
3
[Disturbance of hypothalamic-pituitary hormone secretion in familial chorea-acanthocytosis]. 53 62
7669403 1995
4
Pathogenesis of pituitary Cushing's syndrome. Pituitary versus hypothalamic. 53 62
7805653 1994
5
An apparent cluster of congenital hypopituitarism in central Massachusetts: magnetic resonance imaging and hormonal studies. 53 62
1846002 1991
6
CRH and lysine-vasopressin stimulation tests in the diagnosis of hypoadrenalism secondary to hypothalamic or pituitary disorders. 53 62
2169450 1990
7
What Works for One May Not Work for Another: A New Warning for Modafinil. 62
36043022 2022
8
Autoimmunity Related to Adipsic Hypernatremia and ROHHAD Syndrome. 62
35805903 2022
9
A new perspective of hypothalamic disease: Shapiro's syndrome. 62
35968294 2022
10
Bexarotene-induced central hypothyroidism assessed by TRH stimulation test in cutaneous T-cell lymphoma patients. 62
34433736 2022
11
European guideline and expert statements on the management of narcolepsy in adults and children. 62
34173288 2021
12
European guideline and expert statements on the management of narcolepsy in adults and children. 62
34173695 2021
13
Effects of Childhood Multidisciplinary Care and Growth Hormone Treatment on Health Problems in Adults with Prader-Willi Syndrome. 62
34362034 2021
14
Biochemical transition during triphasic postpartum thyroiditis: confusion with central hypothyroidism. 62
34280894 2021
15
Multidisciplinary Approach for Hypothalamic Obesity in Children and Adolescents: A Preliminary Study. 62
34206290 2021
16
Case Report: A Rare Case of Coexisting of Autoimmune Polyglandular Syndrome Type 3 and Isolated Gonadotropin-Releasing Hormone Deficiency. 62
34594339 2021
17
"Non-Classical" Indication for Provocative Testing of Growth Hormone: A Retrospective Cohort Study in Adult Patients Under Replacement Therapy. 62
32990548 2021
18
Missed Diagnoses and Health Problems in Adults With Prader-Willi Syndrome: Recommendations for Screening and Treatment. 62
32877518 2020
19
Conventional autoantibodies against brain antigens are not routinely detectable in serum and CSF of narcolepsy type 1 and 2 patients. 62
32858359 2020
20
Testosterone Supplementation Rescues Spermatogenesis and In Vitro Fertilizing Ability of Sperm in Kiss1 Knockout Mice. 62
32514526 2020
21
Sarcoidosis and the Nervous System. 62
32487903 2020
22
Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment. 62
31324898 2019
23
Management of hypothalamic disease in patients with craniopharyngioma. 62
30614015 2019
24
Adipsic Diabetes Insipidus-The Challenging Combination of Polyuria and Adipsia: A Case Report and Review of Literature. 62
31620086 2019
25
A hotspots analysis-relation discovery representation model for revealing diabetes mellitus and obesity. 62
30547805 2018
26
Reference intervals for thyrotropin in an area of Northern Italy: the Pordenone thyroid study (TRIPP). 62
29340973 2018
27
Hypothermia in Multiple Sclerosis: Beyond the Hypothalamus? A Case Report and Review of the Literature. 62
29755800 2018
28
Pediatric Adrenal Insufficiency: Diagnosis, Management, and New Therapies. 62
30515225 2018
29
[The hypothalamus in Huntington's disease]. 62
29071701 2017
30
Diabetes insipidus and hypopituitarism in HIV: an unexpected cause. 62
28620498 2017
31
Central hypothyroidism and its role for cardiovascular risk factors in hypopituitary patients. 62
27481361 2016
32
[Addison's disease : Primary adrenal insufficiency]. 62
27129928 2016
33
The Evaluation of Adrenal Function in Two Cases of Hypocortisolism Accompanied by Liver Cirrhosis. 62
27041161 2016
34
Paraneoplastic limbic encephalitis with associated hypothalamitis mimicking a hyperdense hypothalamic tumor: a case report. 62
26782815 2016
35
Management of Craniopharyngioma - Perspectives beyond Surgery and Endocrinology. 62
29632577 2015
36
Oral manifestations of hypothyroidism: a case report. 62
24995258 2014
37
Psychotropic-induced hyperprolactinemia: a clinical review. 62
24140188 2014
38
Comparison of body composition, basal metabolic rate and metabolic outcomes of adults with Prader Willi syndrome or lesional hypothalamic disease, with primary obesity. 62
23318724 2013
39
GLP-1 analogues as a new treatment option for hypothalamic obesity in adults: report of nine cases. 62
23392214 2013
40
Hypothalamic germinoma masquerading as superior mesenteric artery (SMA) syndrome. 62
23186972 2013
41
Development and validation of a new questionnaire assessing quality of life in adults with hypopituitarism: Adult Hypopituitarism Questionnaire (AHQ). 62
22984490 2012
42
Management of subclinical hyperthyroidism. 62
23843809 2012
43
Partial hypopituitarism and Langerhans cell histiocytosis. 62
22715201 2011
44
Disorder in the serotonergic system due to tryptophan hydroxylation impairment: a cause of hypothalamic syndrome? 62
20190542 2010
45
Slow-growing craniopharyngioma masquarading as early-onset eating disorder: two cases. 62
19115368 2009
46
[Visual pathway and pituitary stalk protection in pituitary tumor surgery and the clinical outcome]. 62
19246307 2009
47
Clinical perspectives on the genetics of schizophrenia: a bottom-up orientation. 62
19073422 2008
48
Androgens may mediate a relative preservation of IGF-I levels in overweight and obese women despite reduced growth hormone secretion. 62
18647804 2008
49
Diagnostic usefulness of the growth hormone-releasing peptide-2 test as a substitute for the insulin tolerance test in hypopituitarism. 62
18493103 2008
50
Growth hormone deficiency by growth hormone releasing hormone-arginine testing criteria predicts increased cardiovascular risk markers in normal young overweight and obese women. 62
18445664 2008
51
Use of somatostatin analogues in obesity. 62
18778119 2008
52
Prader-Willi syndrome: atypical psychoses and motor dysfunctions. 62
16697294 2006
53
Hypopituitarism. 62
17077946 2006
54
Neurocognitive function in adults with growth hormone deficiency. 62
16439853 2005
55
Effects of medications on regulation of body temperature of patients with Tourette syndrome. 62
15119484 2004
56
Is the thyrotropin-releasing hormone test necessary in the diagnosis of central hypothyroidism in children. 62
14671155 2003
57
Tourette syndrome associated with body temperature dysregulation: possible involvement of an idiopathic hypothalamic disorder. 62
12546427 2002
58
Osteopenic mice: animal models of the aging skeleton. 62
15758436 2002
59
Diagnosis and management of growth hormone deficiency in adults. 62
11571930 2001
60
Serum thyroid-stimulating hormone measurement for assessment of thyroid function and disease. 62
11444162 2001
61
Basal, pulsatile, entropic, and 24-hour rhythmic features of secondary hyperprolactinemia due to functional pituitary stalk disconnection mimic tumoral (primary) hyperprolactinemia. 62
11297584 2001
62
Central control of bone formation. 62
11368306 2001
63
Pituitary-thyroid feedback hypersensitivity as a novel cause of hypothyroidism in children. 62
11072946 2000
64
Experience with cyproterone acetate in the treatment of precocious puberty. 62
10969925 2000
65
Clinical diagnosis of hyper- and hypocortisolism. 62
12689470 2000
66
An 11-year-old girl with syndrome of inappropriate antidiuretic hormone secretion. 62
10522340 1999
67
Kleine-Levin and Munchausen syndromes in a patient with recurrent acromegaly. 62
10069657 1999
68
Pulsatile GnRH or human chorionic gonadotropin/human menopausal gonadotropin as effective treatment for men with hypogonadotropic hypogonadism: a review of 42 cases. 53
9758439 1998
69
One century after the description of the "sign": Joseph Babinski and his contribution to neurosurgery. 62
9092856 1997
70
Clinical review 86: Euthyroid sick syndrome: is it a misnomer? 62
9024211 1997
71
Obese (ob) gene defects are rare in human obesity. 62
9061713 1997
72
Hypothalamic disease: neurosecretory dysfunction and parasellar lesions. 62
9174692 1997
73
Hyperprolactinemia. 62
29224529 1996
74
A comparison between short ACTH and insulin stress tests for assessing hypothalamo-pituitary-adrenal function. 62
8706316 1996
75
Endocrine abnormalities in hemodialysis patients with iron overload: reversal with iron depletion. 62
8748213 1995
76
Primary Amenorrhea and Persistent Stress Fracture. 62
29272181 1995
77
High efficacy of gonadotropin or pulsatile gonadotropin-releasing hormone treatment in hypogonadotropic hypogonadal men. 53
7921222 1994
78
[A case of dural type of histiocytosis X presenting as a mass lesion in the tentorium cerebelli]. 62
8196835 1994
79
Brain tumors and anorexia nervosa syndrome. 62
7943600 1994
80
Anophthalmia, cleft lip/palate, facial anomalies, and CNS anomalies and hypothalamic disorder in a newborn: a midline developmental field defect. 62
8160751 1994
81
Chronic hypothermia and water intoxication associated with a neurodegenerative disease. 62
8121871 1993
82
Plasma levels of corticotropin-releasing hormone in hypothalamic-pituitary-adrenal disorders and chronic renal failure. 53
8393256 1993
83
The neuropsychiatry of chronic fatigue syndrome. 62
8491099 1993
84
[Metabolic effects of obesity in men]. 62
8128779 1993
85
Corticotropin-releasing hormone and adrenocorticotropic hormone concentrations in cerebrospinal fluid of dogs with pituitary-dependent hyperadrenocorticism. 62
1332844 1992
86
Diencephalic idiopathic gliosis: an unusual hypothalamic syndrome of dermopathy, diarrhea and growth arrest. 62
1430843 1992
87
Hypothalamic failure as a sequela of heterozygous protein C deficiency? 62
1628670 1992
88
Neurologic manifestations of hypothalamic disease. 62
1480755 1992
89
Variable hormonogenesis in Cushing's syndrome. 62
1649480 1991
90
Hypogonadism of male prolactinomas: relation to pulsatile secretion of LH. 62
2099670 1990
91
Dopamine-mediated effects induced by metoclopramide simultaneously on adrenocorticotropic hormone and prolactin in patients with pituitary and/or hypothalamic disorders. 53
2174755 1990
92
Very-low-calorie diet-induced weight reduction reverses impaired growth hormone secretion response to growth hormone-releasing hormone, arginine, and L-dopa in obesity. 62
2118219 1990
93
Induction of ovulation with pulsatile gonadotropin releasing hormone (GnRH) in anovulatory women. 53
2132474 1990
94
The use and limitations of a chemiluminescent thyrotropin assay as a single thyroid function test in an out-patient endocrine clinic. 62
2394778 1990
95
[A case of recessive dystrophic epidermolysis bullosa associated with dwarfism with special reference to pathophysiological role of growth hormone]. 62
2332081 1990
96
[Prader-Willi-Labhart syndrome: relations with the hypothalamus and chromosome 15]. 62
2130760 1990
97
[Acute hemorrhage and ischemic necroses in hypophyseal tumors: hypophyseal apoplexy]. 62
2599499 1989
98
[Kleine-Levin syndrome. The provocation of manic symptoms by an antidepressant and a therapeutic trial of carbamazepine]. 62
2791906 1989
99
Volume homeostasis and osmoregulation in human pregnancy. 62
2698144 1989
100
Hypothalamic disease in association with dysgenesis of the corpus callosum. 62
2813236 1989
101
Hypothalamic-pituitary dysfunction in polycystic ovarian disease. 62
3143565 1988
102
Altered pulsatile pattern of luteinizing hormone in men with idiopathic normogonadotropic oligospermia. 62
3135207 1988
103
Primary histiocytosis X of the parieto-occipital lobe. 62
3259535 1988
104
Hypercortisolism in patients with functional hypothalamic-amenorrhea. 62
3346352 1988
105
Epidemiology of infertility and polycystic ovarian disease: endocrinological and demographic studies. 62
3140583 1987
106
Symptomatic hypothalamic-pituitary dysfunction in nasopharyngeal carcinoma patients following radiation therapy: a retrospective study. 62
3624043 1987
107
Neuroendocrine syndromes of the hypothalamus. 62
3540584 1986
108
Hypothalamic dysfunction following whole-brain irradiation. 62
3760958 1986
109
Late recurrence of surgically removed prolactinomas. 62
3697940 1986
110
Growth hormone response to low dose intravenous injections of growth hormone releasing factor in obese and normal weight women. 62
2871950 1986
111
Hypothalamic disease presenting as amenorrhoea: value of computed tomography. 62
4084469 1985
112
Comparison of insulin hypoglycemia and short metyrapone tests in patients with pituitary disease. 62
3900556 1985
113
Impaired growth hormone response to growth hormone releasing factor and insulin-hypoglycaemia in obesity. 62
2863016 1985
114
Plasma growth hormone response to synthetic GH-RH1-44 in 52 children and adults with growth hormone deficiency of various etiologies. 62
3928474 1985
115
Isolated follicle-stimulating hormone deficiency in men: successful long-term gonadotropin therapy. 62
6436064 1984
116
[Psychological characteristics of women with postpartum hypothalamic disorder]. 62
6500400 1984
117
Effects of human pancreatic tumour growth hormone releasing factor on growth hormone and somatomedin C levels in patients with idiopathic growth hormone deficiency. 62
6134978 1983
118
Primary empty sella, hyperprolactinemia, and isolated ACTH deficiency after postpartum hemorrhage. 62
6301277 1983
119
The Prader-Willi syndrome: neuroendocrine study of identical twins. 62
6683267 1983
120
Response to TRH in suspected hypopituitarism. 62
6404226 1983
121
Prolactin response to the dopamine antagonists sulpiride and domperidone. Further evidence for pituitary dopamine deficiency in hyperprolactinemic disorders of different etiology. 62
6642291 1983
122
A comparison of pituitary cells from lean and obese Zucker Rats. 62
6828456 1983
123
Functional characterization of hypothalamic hyperprolactinemia. 62
6811605 1982
124
[Pharmacological studies in hypothalamic disorder-induced obesity in mice. Effect of anti-inflammatory and analgesic agents on hypothalamic disorder-induced obesity in mice]. 62
6821303 1982
125
Gonadotropin responsiveness to luteinizing hormone releasing hormone in prepubertal and pubertal patients with growth hormone deficiency. 62
6814178 1982
126
The response of prolactin to chlorpromazine stimulation in men with hypogonadotrophic hypogonadism and early pubertal boys: relationship to sex steroid exposure. 62
6807580 1982
127
Postcraniotomy diabetes insipidus. Who's at risk? 62
7060374 1982
128
Plasma prolactin and gonadotrophins in anorexia nervosa and amenorrhoea due to weight loss. 62
6791425 1981
129
Evidence for the hypothalamic origin of the polycystic ovary syndrome. 62
6454866 1981
130
Studies of hypothalamic function in Huntington's chorea. 62
6455503 1981
131
Sexual and hypothalamic dysfunction in the postconcussional syndrome. 62
6782821 1981
132
Hypernatraemia, diabetes mellitus, hyperprolactinaemia, retarded growth and delayed puberty in a 14 year old girl. Effect of bromocriptine treatment. 62
7006294 1981
133
Hyperprolactinemia in chronic renal failure: impaired responsiveness to stimulation and suppression. Normalization after transplantation. 62
6791043 1981
134
Synthesis of DNA in oestrogen-induced pituitary tumurs in rats: effect of bromocriptine. 62
7430920 1980
135
Increased slow wave sleep in a hypopituitary dwarf. 62
7393788 1980
136
Repetitive infusion of gonadotropin-releasing hormone distinguishes hypothalamic from pituitary hypogonadism. 62
372209 1979
137
Prolactin levels and bromocriptine treatment of short luteal phase. 62
37181 1979
138
[Hypothalamic control of TSH secretion. Current methods of exploration and perspectives for the future]. 62
159769 1979
139
Epileptic laughter with precocious puberty. 62
747405 1978
140
Endocrine evaluation of the infertile male. 62
734814 1978
141
Plasma TSH and prolactin response to insulin induced hypoglycemia in patients with hypothalamic pituitary disorders. 62
710372 1978
142
[The neurophysins (author's transl)]. 62
736518 1978
143
The secretion of thyrotrophin with impaired biological activity in patients with hypothalamic-pituitary disease. 62
647990 1978
144
Sexual precocity in association with septo-optic dysplasia and hypothalamic hypopituitarism. 62
205644 1978
145
Hypothalamic hypothyroidism causing spastic paraplegia: recovery following thyroid medication. 62
727728 1978
146
Cushing's syndrome associated with galactorrhea, amenorrhea, and hypothyroidism: a primary hypothalamic disorder. 62
591615 1977
147
Radiological aspects of pituitary--hypothalamic disease. 62
330035 1977
148
Correlation between integrated LH and FSH levels and the response to luteinizing hormone relasing factor (LRF). 62
794076 1976
149
Adrenal function in the diabetic mutant mouse (gene symbol dbm). 62
998290 1976
150
Diagnosis of radiosensitive hypothalamic tumors without craniotomy: endocrine and neuroradiologic studies of intracranial atypical teratomas. 62
786092 1976
151
The effects of clomiphene citrate on the hypothalamic-pituitary-gonadal axis in anorexia nervosa. 62
996198 1976
152
Pregnancy following 2-bromo-alpha-ergocryptine (CB-154)-induced ovulation in an acromegalic patient with galactorrhea and amenorrhea. 62
943332 1976
153
FSH and LH response to LHRF in Kallman's syndrome. 62
765905 1976
154
Some aspects of hypothalamic-pituitary function in patients with anorexia nervosa. 62
813472 1976
155
Periodic apnea, exercise hypoventilation, and hypothalamic dysfunction. 62
1252044 1976
156
Hyperprolactinemia in sarcoidosis: incidence and utility in predicting hypothalamic involvement. 62
1171648 1975
157
Effect of synthetic gonadotropin-releasing hormone (GnRH) in a patient with the "fertile eunuch" syndrome. 62
1097462 1975
158
The pituitary-adrenal system of the genetically obese (ob/ob) mouse. 62
167093 1975
159
In vitro testing of thyroid function: a review. 62
806877 1975
160
Evidence that acromegaly is not a hypothalamic disease. 62
4363384 1973
161
[Clinico-neuroendocrinological study of diencephalon-hypophysis diseases. 3. Patterns and endocrinological findings in hypothalamic disorder]. 62
5466327 1970
162
A comparative study of endocrine tests in hypothalamic disease. Circadian periodicity of plasma 11-OHCS levels, plama 11-OHCS and growth hormone response to insulin hypoglycemia and metyrapone responsiveness. 62
5697039 1968
163
[Paroxysmal atrial tachycardia in the course of chronic multisymptomatic hypothalamic disease]. 62
6063355 1967
164
Evaluation of ACTH reserve in pituitary-hypothalamic disease. 62
4288690 1966
165
Probable Hypothalamic Disorder Requiring Corticoid Therapy in Patients with Pituitary Adenoma or Craniopharyngioma. 62
20327312 1962
166
Dysrhythmia associated with proved hypothalamic disease. Fourteen- and six-per-second dysrhythmia. 62
14465902 1962
167
[Clinical data on hypothalamic disease]. 62
13774634 1960
168
[Testicular insufficiency in the adult caused by hypothalamic disorder; report on 2 clinical cases]. 62
13538018 1958
169
Premature pubarche; a hypothalamic disorder? Report of 17 cases. 62
14375676 1955
170
Endocrine and other clinical manifestations of hypothalamic disease; a survey of 60 cases, with autopsies. 62
13130650 1954
171
Homicide as a manifestation of thalamic or hypothalamic disorder with abnormal electroencephalographic findings. 62
13039293 1953
172
Matricide with electroencephalographic evidence of thalamic or hypothalamic disorder. 62
13020966 1953

Variations for Hypothalamic Disease

Expression for Hypothalamic Disease

Search GEO for disease gene expression data for Hypothalamic Disease.

Pathways for Hypothalamic Disease

Pathways related to Hypothalamic Disease according to GeneCards Suite gene sharing:

(showing 21, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.28 PRL INS IGF1 GNRH1 GHRH GH1
2
Show member pathways
13.28 TSHB TRH POMC HCRT GNRH1 GHRH
3
Show member pathways
12.99 AVP CRH GHRH GNRH1 HCRT POMC
4
Show member pathways
12.78 INS IGF1 GNRH1 GHRH GH1
5 12.74 TSHB TRH POMC INS IGF1 HCRT
6
Show member pathways
12.46 IGF1 GNRH1 GHRH GH1
7
Show member pathways
12.41 POMC GHRH GH1 CRH
8
Show member pathways
12.4 IGF1 GNRH1 GHRH GH1
9
Show member pathways
12.14 IGF1 GNRH1 GHRH GH1
10 11.84 GH1 IGF1 INS
11
Show member pathways
11.78 TSHB POMC INS IGF1 GH1
12
Show member pathways
11.56 TSHB POMC GHRH CRH AVP
13 11.55 POMC TRH TSHB
14 11.47 IGF1 GNRH1 GHRH GH1
15 11.4 POMC INS GNRH1 GHRH
16
Show member pathways
11.07 TRH POMC
17
Show member pathways
11.05 POMC CRH
18 10.85 PRL POMC INS
19 10.78 IGF1 GNRH1 GHRH GH1
20 10.59 TSHB GNRH1
21 10.28 POMC CRH

GO Terms for Hypothalamic Disease

Cellular components related to Hypothalamic Disease according to GeneCards Suite gene sharing:

(showing 4, show less)
# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.96 AVP CRH GH1 GHRH GNRH1 IGF1
2 secretory granule GO:0030141 9.86 TRH POMC HCRT AVP
3 extracellular region GO:0005576 9.7 TSHB TRH PRL POMC INS IGF1
4 endosome lumen GO:0031904 9.63 PRL INS GH1

Biological processes related to Hypothalamic Disease according to GeneCards Suite gene sharing:

(showing 7, show less)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.03 AVP CRH GH1 GNRH1 IGF1 INS
2 positive regulation of cell population proliferation GO:0008284 10.02 PRL INS IGF1 GHRH AVP
3 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.85 INS IGF1 GH1
4 positive regulation of glycogen biosynthetic process GO:0045725 9.71 INS IGF1
5 negative regulation of transmission of nerve impulse GO:0051970 9.56 HCRT AVP
6 cell-cell signaling GO:0007267 9.47 TSHB TRH POMC INS GNRH1 GHRH
7 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.43 IGF1 GHRH GH1

Molecular functions related to Hypothalamic Disease according to GeneCards Suite gene sharing:

(showing 4, show less)
# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.6 TSHB TRH PRL POMC INS IGF1
2 insulin-like growth factor receptor binding GO:0005159 9.56 INS IGF1
3 neuropeptide hormone activity GO:0005184 9.56 HCRT GHRH CRH AVP
4 prolactin receptor binding GO:0005148 9.46 PRL GH1

Sources for Hypothalamic Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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