MCID: HYP002
MIFTS: 18

Hypothalamic Neoplasm

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Hypothalamic Neoplasm

MalaCards integrated aliases for Hypothalamic Neoplasm:

Name: Hypothalamic Neoplasm 12 15
Hypothalamic Neoplasms 44 73
Neoplasm of the Hypothalamus 12
Tumor of Hypothalamus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3644
MeSH 44 D007029
NCIt 50 C3129
UMLS 73 C0020659

Summaries for Hypothalamic Neoplasm

MalaCards based summary : Hypothalamic Neoplasm, also known as hypothalamic neoplasms, is related to dementia and diencephalic syndrome. An important gene associated with Hypothalamic Neoplasm is TRPC6 (Transient Receptor Potential Cation Channel Subfamily C Member 6). The drugs Hydrocortisone and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include hypothalamus and pituitary.

Related Diseases for Hypothalamic Neoplasm

Diseases related to Hypothalamic Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 dementia 9.8
2 diencephalic syndrome 9.8

Symptoms & Phenotypes for Hypothalamic Neoplasm

Drugs & Therapeutics for Hypothalamic Neoplasm

Drugs for Hypothalamic Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 150)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone Approved, Vet_approved Phase 4,Not Applicable 50-23-7 5754
2
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
3
Hydrocortisone acetate Approved, Vet_approved Phase 4,Not Applicable 50-03-3
4
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
5
Octreotide Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 83150-76-9 383414 6400441
6
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
7
Ibuprofen Approved Phase 4 15687-27-1 3672
8
Morphine Approved, Investigational Phase 4 57-27-2 5288826
9
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
10
Acetaminophen Approved Phase 4 103-90-2 1983
11
Somatostatin Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 51110-01-1, 38916-34-6 53481605
12
Pasireotide Approved Phase 4,Phase 2,Phase 3 396091-73-9 9941444
13
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
14
Cefdinir Approved Phase 4 91832-40-5 6915944
15
leucovorin Approved Phase 4,Phase 1 58-05-9 6006 143
16
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
17
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
18
Cefazolin Approved Phase 4 25953-19-9 656510 33255
19
Sulfamethoxazole Approved Phase 4 723-46-6 5329
20
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1 59-30-3 6037
21
Lactitol Investigational Phase 4 585-86-4 3871
22 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Adrenergic alpha-Agonists Phase 4
24 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
25 Hydrocortisone-17-butyrate Phase 4,Not Applicable
26 Pharmaceutical Solutions Phase 4,Phase 3
27 Adrenergic Agents Phase 4
28 Hypnotics and Sedatives Phase 4,Phase 1,Not Applicable
29 Analgesics, Non-Narcotic Phase 4
30 Anti-Inflammatory Agents Phase 4,Phase 1,Not Applicable
31 Central Nervous System Depressants Phase 4,Phase 1,Not Applicable
32 Adrenergic alpha-2 Receptor Agonists Phase 4
33 Anesthetics Phase 4,Phase 1,Not Applicable
34 Adrenergic Agonists Phase 4
35 Analgesics Phase 4,Not Applicable
36 Hydrocortisone 17-butyrate 21-propionate Phase 4,Not Applicable
37 Cortisol succinate Phase 4,Not Applicable
38 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
39 glucocorticoids Phase 4,Phase 1,Not Applicable
40 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
41 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
42 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Anti-Inflammatory Agents, Non-Steroidal Phase 4
45 Antirheumatic Agents Phase 4
46 Narcotics Phase 4,Not Applicable
47 Cyclooxygenase Inhibitors Phase 4
48 Analgesics, Opioid Phase 4,Not Applicable
49 Anti-Bacterial Agents Phase 4,Not Applicable
50 Antibiotics, Antitubercular Phase 4,Not Applicable

Interventional clinical trials:

(show top 50) (show all 93)
# Name Status NCT ID Phase Drugs
1 Effect of Dexmedetomidine on Plasmatic Cortisol Response in Transsphenoidal Surgery Unknown status NCT02549768 Phase 4 Dexmedetomidine;Sodium Chloride 0.9%
2 Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions Unknown status NCT02190994 Phase 4 Hydrocortisone;Prednisone
3 Pediatric Hypothalamic Obesity Completed NCT00076362 Phase 4 Sandostatin LAR
4 Analgesia Regimens Following Trans-sphenoidal Surgery for Pituitary Tumors Completed NCT02351700 Phase 4 IV Caldolor (IV Ibuprofen);IV Ibuprofen placebo
5 Surgical Debulking of Pituitary Adenomas Completed NCT01371643 Phase 4 Octreotide LAR
6 Comparative Low and High Dose of Dexmedethomidine in Pituitary Tumor Removal by Transphenoid Approach Recruiting NCT03132259 Phase 4 high dose dexmedethomidine;low dose dexmedethomidine
7 Prophylactic Oral Antibiotics on Sinonasal Outcomes Following Endoscopic Transsphenoidal Surgery for Pituitary Lesions Recruiting NCT03014687 Phase 4 Placebo;Oral Antibiotics cefdinir or trimethoprim/sulfamethoxazole
8 Study to Allow Access to Pasireotide for Patients Benefiting From Pasireotide Treatment in a Novartis-sponsored Study. Recruiting NCT01794793 Phase 4 Pasireotide
9 Cabergoline in Nonfunctioning Pituitary Adenomas Completed NCT03271918 Phase 3 Cabergoline
10 Response to Cabergoline and Pasireotide in Non-functioning Pituitary Adenomas and Resistant Prolactinomas Completed NCT01620138 Phase 2, Phase 3 Pasireotide;cabergoline
11 Study of Cabergoline in Treatment of Corticotroph Pituitary Tumor Completed NCT00889525 Phase 3 Cabergoline
12 Energy Balance & Weight Loss in Craniopharyngioma-related or Other Hypothalamic Tumors in Hypothalamic Obesity Recruiting NCT02664441 Phase 3 Exenatide;placebo
13 Ga-68-DOTATOC -PET in the Management of Pituitary Tumours Recruiting NCT02419664 Phase 3
14 Dopamine Agonist Treatment of Non-functioning Pituitary Adenomas Recruiting NCT02288962 Phase 3 cabergoline
15 Multicenter Evaluation of the Effect of Upfront Radiosurgery on Residual Growth Hormone-secreting Pituitary Adenoma Not yet recruiting NCT03439709 Phase 3 Lanreotide 60Mg Solution for Injection
16 Safety and Efficacy of FolateScan (Technetium Tc 99m EC20) in Subjects With Pituitary Tumors Completed NCT01689727 Phase 2 Technetium Tc 99m EC20
17 Evaluate the Efficacy and Safety of Pasireotide LAR on the Treatment of Patients With Clinically Non-Functioning Pituitary Adenoma. Completed NCT01283542 Phase 2 Pasireotide LAR
18 Sandostatin LAR Depot vs. Surgery for Treating Acromegaly Completed NCT00001860 Phase 2 Sandostatin LAR Depot versus transsphenoidal surgery
19 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
20 Pasireotide LAR Therapy of Silent Corticotroph Pituitary Tumors Recruiting NCT02749227 Phase 2 Pasireotide LAR
21 Targeted Therapy With Lapatinib in Patients With Recurrent Pituitary Tumors Resistant to Standard Therapy Recruiting NCT00939523 Phase 2 Lapatinib
22 Study of Pasireotide in Patients With Rare Tumors of Neuroendocrine Origin Terminated NCT00958841 Phase 2 pasireotide LAR
23 Rosiglitazone in Treating Patients With Pituitary Tumors Terminated NCT00616642 Phase 2 rosiglitazone maleate
24 Exploratory Study of Farletuzumab to Treat Resectable, Non-functioning Pituitary Adenomas Withdrawn NCT01203618 Phase 2 Farletuzumab
25 Temozolomide in Treating Patients With Invasive Pituitary Tumors Withdrawn NCT00601289 Phase 2 temozolomide
26 Antineoplaston Therapy in Treating Patients With Neuroendocrine Tumor That Is Metastatic or Unlikely to Respond to Surgery or Radiation Therapy Withdrawn NCT00003514 Phase 2 antineoplaston A10;antineoplaston AS2-1
27 Detection of Functioning Pituitary Microadenoma: PET/MRI Versus PET/CT Recruiting NCT03404414 Phase 1 18F-FDG
28 A Phase 1, Single Dose, Open-Label Study to Investigate the Safety and Efficacy of OTL38 Injection (OTL38) for Intra-operative Imaging of Folate Receptor-alpha Positive Pituitary Adenoma Recruiting NCT02769533 Phase 1 OTL0038;Benadryl
29 Intraoperative Imaging of Pituitary Adenomas by OTL Active, not recruiting NCT02629549 Phase 1 OTL38
30 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
31 Comparison of The Effects of Sevoflurane, Desflurane and Total Intravenous Anaesthesia on Pulmonary Function Tests Unknown status NCT02709863 Not Applicable Sevoflurane;Desflurane;Propofol
32 Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education Tools Unknown status NCT01775332 Not Applicable
33 Prospective Study of Clinically Nonfunctioning Pituitary Adenomas Unknown status NCT01556230
34 Genome-wide Association Study of Pituitary Tumors Unknown status NCT01442220
35 The Predictive Factors of Vision Recovery in Patients With Pituitary Tumor Unknown status NCT01377701
36 The Observational Study of Growth Hormone-secreting Pituitary Tumors Unknown status NCT01368133
37 Characterization of Receptors in Non-functioning Pituitary Macroadenomas Unknown status NCT00852501
38 Pituitary Tumor Surveillance: Pathogenic Correlation Unknown status NCT00599092
39 Prevalence of Pituitary Incidentaloma in Relatives of Patients With Pituitary Adenoma Unknown status NCT00598949
40 The Cardiovascular Changes Associated With Septal Local Anaesthesia Completed NCT03137615 local anaesthetic injection
41 Visual Outcome After Transsphenoidal Surgery for Pituitary Macroadenoma Completed NCT03363126
42 Barrow Nasal Inventory Survey Completed NCT01322945
43 Predictive Factors of Recurrence of Non Functioning Pituitary Adenomas : a Retrospective Study of 220 Patients in the Reims University Hospital, France Completed NCT02803697
44 Mode of Ventilation and Bleeding During Transsphenoidal Surgery Completed NCT01891838 Not Applicable
45 Follow-up Evaluation of Photo-Dynamic Therapy for Pituitary Tumours Completed NCT02632084
46 Glycemic Fluctuations in Newly Diagnosed Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome Subjects Completed NCT02574793
47 Peri-Operative Steroid Management in Patients Completed NCT02084134 Not Applicable hydrocortisone;dexamethasone
48 Identification of GENEtic Markers of Aggressiveness and Malignancy by Array Comparative Genomic Hybrization Analysis (CGH) Completed NCT01903967
49 Comparison of Surgical Approach to Endoscopic Pituitary Adenoma Resection Completed NCT01689064 Not Applicable
50 Calcium Homeostasis in Acromegaly: Effect of Surgical/Medical Treatment and Comparison With Nonfunctioning Pituitary Tumors Completed NCT01568359

Search NIH Clinical Center for Hypothalamic Neoplasm

Cochrane evidence based reviews: hypothalamic neoplasms

Genetic Tests for Hypothalamic Neoplasm

Anatomical Context for Hypothalamic Neoplasm

MalaCards organs/tissues related to Hypothalamic Neoplasm:

41
Hypothalamus, Pituitary

Publications for Hypothalamic Neoplasm

Articles related to Hypothalamic Neoplasm:

# Title Authors Year
1
Hyperphagia, rage, and dementia accompanying a ventromedial hypothalamic neoplasm. ( 5769839 )
1969
2
Diencephalic syndrome of emaciation associated with hypothalamic neoplasms. ( 5939927 )
1966
3
INANITION SYNDROME IN INFANTS WITH ANTERIOR HYPOTHALAMIC NEOPLASMS. ( 14079958 )
1963
4
THE INANITION SYNDROME IN INFANTS WITH ANTERIOR HYPOTHALAMIC NEOPLASMS. ( 14272251 )
1963

Variations for Hypothalamic Neoplasm

Expression for Hypothalamic Neoplasm

Search GEO for disease gene expression data for Hypothalamic Neoplasm.

Pathways for Hypothalamic Neoplasm

GO Terms for Hypothalamic Neoplasm

Sources for Hypothalamic Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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