MCID: HYP002
MIFTS: 20

Hypothalamic Neoplasm

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Hypothalamic Neoplasm

MalaCards integrated aliases for Hypothalamic Neoplasm:

Name: Hypothalamic Neoplasm 12 15 17
Hypothalamic Neoplasms 44 70
Neoplasm of the Hypothalamus 12
Tumor of Hypothalamus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3644
MeSH 44 D007029
NCIt 50 C3129
SNOMED-CT 67 254968009
UMLS 70 C0020659

Summaries for Hypothalamic Neoplasm

MalaCards based summary : Hypothalamic Neoplasm, also known as hypothalamic neoplasms, is related to diencephalic syndrome and syphilitic encephalitis. An important gene associated with Hypothalamic Neoplasm is TRPC6 (Transient Receptor Potential Cation Channel Subfamily C Member 6), and among its related pathways/superpathways is Neuroscience. The drugs Lidocaine and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include hypothalamus and pituitary, and related phenotype is behavior/neurological.

Related Diseases for Hypothalamic Neoplasm

Diseases related to Hypothalamic Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 diencephalic syndrome 9.8
2 syphilitic encephalitis 9.6 TGM1 FLNA
3 orthostatic intolerance 9.6 POMC FLNA
4 west syndrome 9.5 POMC FLNA
5 diencephalic neoplasm 9.0 TRPC6 TGM1 POMC FLNA

Graphical network of the top 20 diseases related to Hypothalamic Neoplasm:



Diseases related to Hypothalamic Neoplasm

Symptoms & Phenotypes for Hypothalamic Neoplasm

MGI Mouse Phenotypes related to Hypothalamic Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 8.92 FLNA POMC TGM1 TRPC6

Drugs & Therapeutics for Hypothalamic Neoplasm

Drugs for Hypothalamic Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved 137-58-6 3676
2 Pharmaceutical Solutions
3 Anesthetics, Local
4 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Observational Study of the Cardiovascular Response to Infiltration of Local Anaesthetic Into the Nasal Septum in Patients Undergoing Trans-sphenoidal Resection of a Pituitary Lesion Completed NCT03137615 local anaesthetic injection

Search NIH Clinical Center for Hypothalamic Neoplasm

Cochrane evidence based reviews: hypothalamic neoplasms

Genetic Tests for Hypothalamic Neoplasm

Anatomical Context for Hypothalamic Neoplasm

MalaCards organs/tissues related to Hypothalamic Neoplasm:

40
Hypothalamus, Pituitary

Publications for Hypothalamic Neoplasm

Articles related to Hypothalamic Neoplasm:

# Title Authors PMID Year
1
Reversal of preoperative catatonic state by surgical resection of an adult-onset craniopharyngioma: case report and review of the literature. 61
19372773 2009
2
Treatment of true precocious puberty with a potent luteinizing hormone-releasing factor agonist: effect on growth, sexual maturation, pelvic sonography, and the hypothalamic-pituitary-gonadal axis. 61
3923027 1985
3
Hyperphagia, rage, and dementia accompanying a ventromedial hypothalamic neoplasm. 61
5769839 1969
4
Diencephalic syndrome of emaciation associated with hypothalamic neoplasms. 61
5939927 1966
5
INANITION SYNDROME IN INFANTS WITH ANTERIOR HYPOTHALAMIC NEOPLASMS. 61
14079958 1963
6
THE INANITION SYNDROME IN INFANTS WITH ANTERIOR HYPOTHALAMIC NEOPLASMS. 61
14272251 1963

Variations for Hypothalamic Neoplasm

Expression for Hypothalamic Neoplasm

Search GEO for disease gene expression data for Hypothalamic Neoplasm.

Pathways for Hypothalamic Neoplasm

Pathways related to Hypothalamic Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.16 TRPC6 POMC

GO Terms for Hypothalamic Neoplasm

Biological processes related to Hypothalamic Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet activation GO:0030168 8.62 TRPC6 FLNA

Molecular functions related to Hypothalamic Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor binding GO:0001664 8.62 POMC FLNA

Sources for Hypothalamic Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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