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MCID: HYP086
MIFTS: 66

Hypothyroidism

Categories: Endocrine diseases, Immune diseases, Metabolic diseases, Neuronal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Hypothyroidism

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MalaCards integrated aliases for Hypothyroidism:

Name: Hypothyroidism 12 77 30 56 6 44 45 15 17 74
Thyroid Diseases 56 44 74
Thyroid Insufficiency 12
Dysfunction Thyroid 56
Thyroid Dysfunction 74
Thyroid Deficiency 12
Thyroid Disease 17

Classifications:

MalaCards categories:
Global: Metabolic diseases Rare diseases
Anatomical: Endocrine diseases Neuronal diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:1459
ICD9CM 36 244.9
MeSH 45 D007037
NCIt 51 C26800
SNOMED-CT 69 40930008
Sources

Summaries for Hypothyroidism

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MedlinePlus : 44 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. It is one of your endocrine glands, which make hormones. Thyroid hormones control the rate of many activities in your body. These include how fast you burn calories and how fast your heart beats. All of these activities are your body's metabolism. Thyroid problems include Goiter - enlargement of the thyroid gland Hyperthyroidism - when your thyroid gland makes more thyroid hormones than your body needs Hypothyroidism - when your thyroid gland does not make enough thyroid hormones Thyroid cancer Thyroid nodules - lumps in the thyroid gland Thyroiditis - swelling of the thyroid To diagnose thyroid diseases, doctors use a medical history, physical exam, and thyroid tests. They sometimes also use a biopsy. Treatment depends on the problem, but may include medicines, radioiodine therapy, or thyroid surgery. Dept. of Health and Human Services Office on Women's Health

MalaCards based summary : Hypothyroidism, also known as thyroid diseases, is related to hypothyroidism, congenital, nongoitrous, 2 and hypothyroidism, central, and testicular enlargement. An important gene associated with Hypothyroidism is RET (Ret Proto-Oncogene), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Allograft rejection. The drugs Selenium and Iodine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, breast and testes, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Disease Ontology : 12 A thyroid gland disease which involves an underproduction of thyroid hormone.

Wikipedia : 77 Hypothyroidism, also called underactive thyroid or low thyroid, is a disorder of the endocrine system in... more...

Sources

Related Diseases for Hypothyroidism

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Diseases in the Hypothyroidism family:

Congenital Hypothyroidism Central Congenital Hypothyroidism
Hypothyroidism Due to Iodide Transport Defect Hypothyroidism Due to Deficient Transcription Factors Involved in Pituitary Development or Function
Congenital Hypothyroidism Due to Maternal Intake of Antithyroid Drugs Congenital Hypothyroidism Due to Transplacental Passage of Tsh-Binding Inhibitory Antibodies

Diseases related to Hypothyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 940)
# Related Disease Score Top Affiliating Genes
1 hypothyroidism, congenital, nongoitrous, 2 34.7 NKX2-1 PAX8 SERPINA7 SLC26A4 TG TSHR
2 hypothyroidism, central, and testicular enlargement 34.5 DUOX2 DUOXA2 TRH TSHB
3 hypothyroidism, congenital, nongoitrous, 4 34.5 SERPINA7 TG TPO TRH TSHB
4 congenital hypothyroidism 34.3 DUOX2 DUOXA2 GLIS3 IYD NKX2-1 NKX2-5
5 postsurgical hypothyroidism 34.3 TG TRH TSHR
6 neonatal hypothyroidism 34.2 PAX8 SLC5A5 TG TPO TSHR
7 pendred syndrome 33.6 DUOX2 PAX8 SLC26A4 TG TPO
8 myxedema 33.4 TG TPO TSHR
9 hashimoto thyroiditis 33.3 RET SLC26A4 TG TPO TSHB TSHR
10 hyperthyroidism 32.9 SERPINA7 TG TPO TRH TSHR
11 graves' disease 32.7 SERPINA7 TG TPO TSHR
12 subacute thyroiditis 32.6 SERPINA7 TG TPO TSHR
13 thyroid crisis 32.1 SERPINA7 TG
14 thyroid gland disease 31.8 DUOXA2 NKX2-1 PAX8 RET SERPINA7 SLC26A4
15 familial thyroid dyshormonogenesis 31.8 DUOX2 DUOXA2 IYD SLC5A5 TG TPO
16 thyroid ectopia 31.8 NKX2-5 PAX8
17 athyreosis 31.7 NKX2-1 NKX2-5 PAX8 SLC26A4 TG TSHR
18 thyroiditis 31.4 RET SERPINA7 TG TPO TRH TSHB
19 graves disease 1 31.4 SERPINA7 TG TPO TRH TSHR
20 goiter 31.2 DUOXA2 IYD NKX2-1 PAX8 SERPINA7 SLC26A4
21 thyroid cancer 30.8 NKX2-1 PAX8 RET SLC26A4 SLC5A5 TG
22 differentiated thyroid carcinoma 30.6 NKX2-1 PAX8 RET TG TPO TSHR
23 endemic goiter 30.6 SERPINA7 TG TPO TSHB TSHR
24 thyroid carcinoma, familial medullary 30.5 NKX2-1 RET TG
25 thyroid hormone resistance, generalized, autosomal dominant 30.4 SERPINA7 TG TRH
26 hyperthyroxinemia 30.3 SERPINA7 TPO TRH TSHR
27 plummer's disease 30.3 TG TPO
28 neonatal thyrotoxicosis 30.3 PAX8 TSHR
29 nodular goiter 30.3 RET SLC5A5 TG TPO TSHR
30 struma ovarii 30.2 NKX2-1 RET TG TSHR
31 papillary thyroid microcarcinoma 30.2 NKX2-1 TG TSHR
32 multinodular goiter 30.2 NKX2-1 PAX8 SLC26A4 TG TPO TSHR
33 papillary carcinoma 30.2 NKX2-1 PAX8 RET TG TPO TSHR
34 goiter, multinodular 1, with or without sertoli-leydig cell tumors 30.0 TG TPO
35 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.0 TG TPO TSHR
36 toxic diffuse goiter 30.0 SERPINA7 TG TPO TRH TSHR
37 pernicious anemia 29.9 TG TPO
38 follicular adenoma 29.8 NKX2-1 PAX8 RET SLC26A4 TG TPO
39 hypothyroidism, congenital, nongoitrous, 1 12.7
40 choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction 12.6
41 central congenital hypothyroidism 12.5
42 hypothyroidism, congenital, nongoitrous, 5 12.5
43 hypothyroidism, congenital, nongoitrous, 6 12.4
44 diabetes mellitus, neonatal, with congenital hypothyroidism 12.4
45 hypothyroidism, congenital, nongoitrous, 3 12.4
46 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 12.4
47 ectodermal dysplasia, hypohidrotic, with hypothyroidism and ciliary dyskinesia 12.3
48 iodine hypothyroidism 12.2
49 autoimmune thyroid disease 1 12.1
50 autoimmune thyroid disease 2 12.1

Comorbidity relations with Hypothyroidism via Phenotypic Disease Network (PDN): (show top 50) (show all 156)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Allergic Rhinitis Alzheimer Disease
Anxiety Aortic Valve Disease 1
Atypical Depressive Disorder Autonomic Nervous System Disease
Basilar Artery Insufficiency Benign Essential Hypertension
Bipolar Disorder Borderline Personality Disorder
Bronchiectasis Bronchitis
Bronchopneumonia Celiac Disease 1
Cerebral Atherosclerosis Cerebral Degeneration
Cerebrovascular Disease Chronic Kidney Failure
Chronic Myocardial Ischemia Chronic Pulmonary Heart Disease
Communicating Hydrocephalus Conjunctivitis
Conn's Syndrome Conversion Disorder
Cystitis Decubitus Ulcer
Deficiency Anemia Delusional Disorder
Dependent Personality Disorder Dermatomycosis
Diabetes Insipidus Diabetic Polyneuropathy
Dyshormonogenic Goiter Dyskinesia of Esophagus
Dysthymic Disorder Encephalopathy
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Esophagitis
Exophthalmos Familial Atrial Fibrillation
Female Breast Cancer Female Stress Incontinence
Femoral Vein Thrombophlebitis First-Degree Atrioventricular Block
Gastroesophageal Reflux Generalized Anxiety Disorder

Graphical network of the top 20 diseases related to Hypothyroidism:



Diseases related to Hypothyroidism
Sources

Symptoms & Phenotypes for Hypothyroidism

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MGI Mouse Phenotypes related to Hypothyroidism:

47 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.3 CHD7 DUOX2 GLIS3 NKX2-1 NKX2-5 PAX8
2 growth/size/body region MP:0005378 10.25 CHD7 DUOX2 GLIS3 NKX2-1 NKX2-5 PAX8
3 homeostasis/metabolism MP:0005376 10.21 CHD7 DUOX2 GLIS3 NKX2-1 NKX2-5 PAX8
4 cellular MP:0005384 10.19 CHD7 GLIS3 GNB1 NKX2-1 NKX2-5 PAX8
5 mortality/aging MP:0010768 10.03 ADNP CHD7 DUOXA2 GLIS3 GNB1 NKX2-1
6 digestive/alimentary MP:0005381 10.02 CHD7 NKX2-1 NKX2-5 RET SLC26A4 STAT1
7 nervous system MP:0003631 9.97 ADNP CHD7 DUOX2 GNB1 NKX2-1 NKX2-5
8 limbs/digits/tail MP:0005371 9.92 CHD7 DUOXA2 PAX8 RET STAT1 TG
9 hearing/vestibular/ear MP:0005377 9.88 CHD7 DUOX2 PAX8 SLC26A4 TPO TSHR
10 reproductive system MP:0005389 9.56 CHD7 DUOX2 NKX2-1 PAX8 RET SLC26A4
11 skeleton MP:0005390 9.32 CHD7 DUOX2 DUOXA2 NKX2-1 PAX8 SLC26A4
Sources

Drugs & Therapeutics for Hypothyroidism

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Drugs for Hypothyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 898)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Selenium Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 7782-49-2
2
Iodine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 7553-56-2 807
3
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 68602 5311068
4
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
5
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
6
Methimazole Approved Phase 4,Phase 2,Phase 1,Not Applicable 60-56-0 1349907
7
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
8
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
9
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
10
Nitroprusside Approved, Investigational Phase 4 15078-28-1 11963622
11
Nitric Oxide Approved Phase 4,Not Applicable 10102-43-9 145068
12
Propylthiouracil Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 51-52-5 657298
13
Betamethasone Approved, Vet_approved Phase 4,Phase 3 378-44-9 9782
14
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
15
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 53-03-2 5865
16
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
17
Amiodarone Approved, Investigational Phase 4,Phase 3,Not Applicable 1951-25-3 2157
18
tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1401-55-4
19
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 94-09-7, 1994-09-7 2337
20
Somatostatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 38916-34-6, 51110-01-1 53481605
21
Pasireotide Approved Phase 4,Phase 3,Phase 2 396091-73-9 9941444
22
Octreotide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 83150-76-9 6400441 383414
23
lanreotide Approved Phase 4,Phase 2 108736-35-2
24
Sodium Citrate Approved, Investigational Phase 4,Phase 2,Phase 1,Early Phase 1 68-04-2
25
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 302-25-0
26
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-24-8 5755
27
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 2921-57-5
28
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 83-43-2 6741
29
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 6006 143
30
Iron Approved, Experimental Phase 4,Phase 2,Phase 1,Not Applicable 7439-89-6, 15438-31-0 23925 27284
31
Hydroxocobalamin Approved Phase 4,Phase 2,Not Applicable 13422-51-0 11953898 15589840
32
Bexarotene Approved, Investigational Phase 4,Phase 3,Phase 1,Early Phase 1 153559-49-0 82146
33
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 2,Phase 3 198153-51-4 5360545
34
Ribavirin Approved Phase 4,Phase 2,Phase 3 36791-04-5 37542
35
Triamcinolone Approved, Vet_approved Phase 4,Not Applicable 124-94-7 31307
36
Testosterone Approved, Experimental, Investigational Phase 4,Phase 1,Not Applicable,Early Phase 1 58-22-0, 481-30-1 6013 10204
37
Polyestradiol phosphate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 28014-46-2
38
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-28-2 5757
39
Dinoprost tromethamine Approved, Vet_approved Phase 4,Not Applicable 38562-01-5 5282415
40
Dinoprost Approved, Investigational Phase 4,Not Applicable 551-11-1 5283078
41
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 525-66-6 4946
42
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1177-87-3
43
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
44
Peginterferon alfa-2b Approved Phase 4,Phase 2,Phase 3 99210-65-8, 215647-85-1
45
Sunitinib Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 557795-19-4, 341031-54-7 5329102
46
Glucagon Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 16941-32-5
47
Liraglutide Approved Phase 4,Phase 3,Phase 2,Not Applicable 204656-20-2 44147092
48
Parathyroid hormone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9002-64-6
49
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Not Applicable 103-90-2 1983
50
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 64-17-5 702

Interventional clinical trials:

(show top 50) (show all 2019)
# Name Status NCT ID Phase Drugs
1 Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism Unknown status NCT02316743 Phase 4 Levothyroxine supplementation
2 Thyroxine Titration Study Unknown status NCT00111735 Phase 4 Thyroxine
3 Thyroid Study Type 2 Diabetes Mellitus (T2DM) Unknown status NCT01379170 Phase 4 Euthyrox (levothyroxine)
4 Selenium Supplementation in Youths With Autoimmune Thyroiditis Unknown status NCT02644707 Phase 4
5 rAd-p53 Gene Therapy for Advanced Malignant Thyroid Tumors Unknown status NCT00902122 Phase 4 rAd-p53 gene;p53 gene therapy
6 Radiolabeled Molecules for Medullary Thyroid Cancer Unknown status NCT01915485 Phase 4
7 Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General Anesthesia Unknown status NCT02613806 Phase 4 Dexmeditomidine;normal saline
8 Etoricoxib for Postoperative Pain After Thyroid Surgery Unknown status NCT00935116 Phase 4 etoricoxib
9 Cardiopulmonary Capacity in Elderly With Different Ranges of Serum Thyroid Stimulating Hormone Unknown status NCT01849861 Phase 4 Methimazole
10 Effect of Propofol on Remifentanil-induced Postoperative Hyperalgesia in Patients Undergoing Thyroid Surgery Unknown status NCT01189721 Phase 4 propofol, sevoflurane
11 Clinical Study Investigating the Effect of Sodium Nitroprusside Infusion on Thyroidal Function Unknown status NCT00636584 Phase 4 sodium nitroprusside;placebo
12 The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy Unknown status NCT01056419 Phase 4 Propylthiouracil
13 Total Thyroidectomy With Harmonic Scalpel® Unknown status NCT00385983 Phase 4
14 The Role of Levothyroxine on Goiter With Atypia of Undetermined Significance Unknown status NCT02329379 Phase 4 Levothyroxine
15 Steroids in the Postoperative Transient Hypoparathyroidism Total Thyroidectomy Unknown status NCT02652884 Phase 4 phosphate and betamethasone acetate, 2 mL.;saline 0.9% NaCl
16 Trial Evaluating Use of Arista in Total Thyroidectomy Unknown status NCT02568085 Phase 4
17 Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions Unknown status NCT02190994 Phase 4 Hydrocortisone;Prednisone
18 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
19 Cardiac Resynchronization in Atrial Fibrillation Trial - a Pilot Study Unknown status NCT01850277 Phase 4 Amiodarone;Pharmacotherapy to slow and control ventricular rate
20 Pasireotide LAR and Pegvisomant Study in Acromegaly Unknown status NCT02668172 Phase 4 Pasireotide LAR 60 mg;Pegvisomant
21 Sildenafil Activates Browning of White Adipose and Improves Insulin Sensitivity Unknown status NCT02524184 Phase 4 sildenafil;placebo
22 AMIOdarone vs. Catheter Ablation for Prevention of Recurrent Symptomatic Atrial Fibrillation Unknown status NCT02341105 Phase 4 Amiodarone
23 Effect of Erythropoietin in Refractory Autoimmune Encephalitis Patients Unknown status NCT03004209 Phase 4 Erythropoietin
24 A Prospective, Randomized Trial of Intravenous Pulse Versus Sequential Steroid Therapy for Patients With Graves' Orbitopathy Unknown status NCT01969019 Phase 4 methylprednisolone, prednisone
25 Effect of Higher Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy Unknown status NCT01761149 Phase 4 Remifentanil
26 Clinical Trial to Evaluate the Efficacy of FITOGYN Versus Placebo on the Vasomotor Symptomatology Associated With Menopause Unknown status NCT01116310 Phase 4 Soy isoflavones (Glycine max L) and red clover extract (Trifolium pretense L);Placebo
27 Thyroid Hormone Replacement for Subclinical Hypothyroidism Completed NCT01660126 Phase 4 Levothyroxine;Placebo
28 Growth Hormone and GnRH Agonist in Adolescents With Acquired Hypothyroidism Completed NCT00206375 Phase 4 Growth hormone;Growth hormone treatment and puberty
29 Neurocognitive and Metabolic Effects of Mild Hypothyroidism Completed NCT00565864 Phase 4 L-thyroxine (L-T4)
30 Effects of L-carnitine on Hypothyroidism Completed NCT01769157 Phase 4 L-carnitine;Placebo
31 Effect of T4-T3 Combination Therapy Versus T4 Monotherapy in Patients With Hypothyroidism Completed NCT00531713 Phase 4 Triiodothyronine
32 Phase 4 Study in Secondary Hypothyroidism: Body Weight Adapted Thyroxin Treatment and Triiodothyronine Supplementation Completed NCT00360074 Phase 4 Thyroxin, Triiodothyronine
33 Effect of Thyroid Hormone Replacement on Fatigability in Untreated Older Adults With Subclinical Hypothyroidism Completed NCT02500342 Phase 4 Levothyroxine;Placebo
34 Study of Radioiodine (131-I) Uptake Following Administration of Thyrogen and Hypothyroid States During Thyroid Hormone Withdrawal. Completed NCT00001730 Phase 4 Thyrogen
35 The TRUST Study - Depression Substudy Completed NCT01853579 Phase 4 Levothyroxine;Placebo
36 Study of Optimal Replacement of Thyroxine in the Elderly Completed NCT01647750 Phase 4 Levothyroxine;Levothyroxine
37 Bioequivalence of Two Levothyroxine Tablet Formulations in Healthy Indian Volunteers Completed NCT01536678 Phase 4 Levothyroxine;Levothyroxine
38 Study to Verify Clinical Utility of Point-of-Care (POC) Thyroid Stimulating Hormone (TSH) Test Kits as Compared to Third Generation TSH Test Kit Completed NCT01921452 Phase 4
39 The TRUST Trial - CardioVascular Imaging ECHO Completed NCT02832960 Phase 4 Levothyroxine;Placebo
40 The TRUST Study - CardioVascular Imaging IMT Completed NCT02832934 Phase 4 Levothyroxine;Placebo
41 Iodine Status of Preschoolers Given Micronutrient Powder for 6 Months Completed NCT02280330 Phase 4
42 Carbohydrate Metabolism Disorder Frequency in Hypertriglyceridemia Induced by Bexarotene of Cutaneous T Cell Lymphoma Completed NCT01569724 Phase 4
43 Short-term Prednisone to Treat STA Study(SPTSS) Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
44 Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction Completed NCT02491008 Phase 4 Levothyroxine;Placebo
45 Safety and Efficacy of Oral Mega Pulse Methylprednisolone in Severe Therapy Resistant Alopecia Areata Completed NCT01167946 Phase 4 methylprednisolone sodium succinate;methylprednisolone sodium succinate;methylprednisolone sodium succinate
46 Long-Term Growth and Skeletal Effects of Early Growth Hormone Treatment in Turner Syndrome Completed NCT00266656 Phase 4 Humatrope
47 A Triple Combination Therapy Study of Boceprevir, Pegasys and Copegus in Previously Untreated Patients With Genotype 1 Chronic Hepatitis C Completed NCT01591460 Phase 4 boceprevir;peginterferon alfa-2a [Pegasys];peginterferon alfa-2a [Pegasys];ribavirin (Copegus];ribavirin (Copegus]
48 Percutaneous Laser Ablation in Benign Thyroid Nodules.Long Term Results Completed NCT00858104 Phase 4
49 Quality of Life, Recombinant TSH (Thyrogen) and Thyroid Cancer Completed NCT00604318 Phase 4 rhTSH
50 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection

Search NIH Clinical Center for Hypothyroidism

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: hypothyroidism

Sources

Genetic Tests for Hypothyroidism

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Genetic tests related to Hypothyroidism:

# Genetic test Affiliating Genes
1 Hypothyroidism 30
Sources

Anatomical Context for Hypothyroidism

About this section

MalaCards organs/tissues related to Hypothyroidism:

42
Thyroid, Breast, Testes, Heart, Brain, Pituitary, Eye
Sources

Publications for Hypothyroidism

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Articles related to Hypothyroidism:

(show top 50) (show all 6683)
# Title Authors Year
1
Hypothyroidism in patients with hepatocellular carcinoma receiving cabozantinib: an unassessed issue. ( 30648889 )
2019
2
Hypothyroidism and the risk of breast cancer recurrence and all-cause mortality - a Danish population-based study. ( 30902106 )
2019
3
Molecular Insights Into the Relationship Between Autoimmune Thyroid Diseases and Breast Cancer: A Critical Perspective on Autoimmunity and ER Stress. ( 30881358 )
2019
4
Optimal Timing of Repeat Newborn Screening for Congenital Hypothyroidism in Preterm Infants to Detect Delayed Thyroid-Stimulating Hormone Elevation. ( 30529133 )
2019
5
The Evaluation of Etiological Distribution and the Rate of Congenital Hypothyroidism among the Cases Referred from National Screening Program. ( 30630811 )
2019
6
An exonic splicing enhancer mutation in DUOX2 causes aberrant alternative splicing and severe congenital hypothyroidism in Bama pigs. ( 30651277 )
2019
7
Determining the TSH reference range in national newborn screening program for congenital hypothyroidism. ( 30700177 )
2019
8
Zebrafish duox mutations provide a model for human congenital hypothyroidism. ( 30700401 )
2019
9
Supratherapeutic maternal iodine supplementation during pregnancy as a cause for congenital hypothyroidism. ( 30746884 )
2019
10
Novel non-synonymous mutations of PAX8 in a cohort of chinese with congenital hypothyroidism. ( 30888984 )
2019
11
Evaluation of the congenital hypothyroidism screening programme in Iran: a 3-year retrospective cohort study. ( 29540462 )
2019
12
Association between subclinical hypothyroidism and depression: an updated systematic review and meta-analysis. ( 30621645 )
2019
13
Relationship between Hypothyroidism and Endometrial Cancer. ( 30705778 )
2019
14
Re: "Association Between Primary Hypothyroidism and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis" by Mantovani et al. (Thyroid 2018;28:1270-1284). ( 30652529 )
2019
15
Are hypothyroidism and hypogonadism clinically relevant in patients with malignant gliomas? A longitudinal trial in patients with glioma. ( 30712840 )
2019
16
Are hypothyroidism and hypogonadism clinically relevant in patients with malignant gliomas? A longitudinal trial in patients with glioma. ( 30389240 )
2019
17
Combination therapy of propranolol, levothyroxine, and liothyronine was effective in a case of severe consumptive hypothyroidism associated with infantile hepatic hemangioma. ( 30745728 )
2019
18
Disruption of the pituitary circadian clock induced by hypothyroidism and hyperthyroidism: consequences on daily pituitary hormone expression profiles. ( 30747053 )
2019
19
Lithium can cause hyperthyroidism as well as hypothyroidism: A systematic review of an under-recognised association. ( 30841715 )
2019
20
Behavior in dogs with spontaneous hypothyroidism during treatment with levothyroxine. ( 30499213 )
2019
21
Trends, Determinants, and Associations of Treated Hypothyroidism in the United Kingdom, 2005-2014. ( 30501570 )
2019
22
The prevalence and correlation between subclinical hypothyroidism and gall stone disease in Baghdad teaching hospital. ( 30546871 )
2019
23
Relatively high rate of postpartum thyroiditis in the Straits of Messina area. Predictivity of both postpartum thyroiditis and permanent hypothyroidism by performing, in the first trimester of gestation, thyroid ultrasonography and measurement of serum thyroperoxidase and thyroglobulin autoantibodies. ( 30555788 )
2019
24
Evidence of hypothyroidism in a portrait by Lorenzo Lotto. ( 30577890 )
2019
25
Central Hypothyroidism and Novel Clinical Phenotypes in Hemizygous Truncation of TBL1X. ( 30591955 )
2019
26
Free thyroid transfer to anterolateral thigh for prevention of radiation induced hypothyroidism: An initial experience. ( 30594401 )
2019
27
Hypothyroidism in the Elderly: Who Should Be Treated and How? ( 30607373 )
2019
28
ER stress contributes to high-fat diet-induced decrease of thyroglobulin and hypothyroidism. ( 30620634 )
2019
29
The influence of subclinical hypothyroidism on serum lipid profile, PCSK9 levels and CD36 expression on monocytes. ( 30641718 )
2019
30
The diagnosis and management of central hypothyroidism in 2018. ( 30645189 )
2019
31
Therapeutic challenges in the application of serum thyroid stimulating hormone testing in the management of patients with hypothyroidism on replacement thyroid hormone therapy: a review. ( 30648440 )
2019
32
Exercise training-induced changes in metabolic syndrome parameters, carotid wall thickness, and thyroid function in middle-aged women with subclinical hypothyroidism. ( 30656407 )
2019
33
Prevalence of iatrogenic hypothyroidism in hyperthyroid cats treated with radioiodine using an individualised scoring system. ( 30667287 )
2019
34
Pregnancy outcomes of antibody negative and untreated subclinical hypothyroidism. ( 30672070 )
2019
35
Analysis of the protective effects of γ-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice. ( 30676163 )
2019
36
Linear and nonlinear analyses of heart rate variability following orthostatism in subclinical hypothyroidism. ( 30681577 )
2019
37
Protective effects of quercetin supplementation against short-term toxicity of cadmium-induced hematological impairment, hypothyroidism, and testicular disturbances in albino rats. ( 30697654 )
2019
38
Subclinical-Hypothyroidism: A Pathology in Evolution. ( 30700355 )
2019
39
Management for women with subclinical hypothyroidism in pregnancy. ( 30709859 )
2019
40
Role of irisin in Chinese patients with hypothyroidism: an interventional study. ( 30722716 )
2019
41
Hyperreactio luteinalis and hypothyroidism: A case report. ( 30723693 )
2019
42
Resolution of Hypothyroidism Restores Cold Induced Thermogenesis in Humans. ( 30724123 )
2019
43
Effect of acute aerobic exercise on arterial stiffness and thyroid-stimulating hormone in subclinical hypothyroidism. ( 30725214 )
2019
44
Pathogenesis of hypothyroidism-induced NAFLD: Evidence for a distinct disease entity? ( 30733187 )
2019
45
Evaluation and management of the child with hypothyroidism. ( 30734891 )
2019
46
The expression of sirtuins, superoxide dismutase, and lipid peroxidation status in peripheral blood from patients with diabetes and hypothyroidism. ( 30736780 )
2019
47
CASE FINDING FOR HYPOTHYROIDISM SHOULD INCLUDE TYPE 2 DIABETES AND METABOLIC SYNDROME PATIENTS: A LATIN AMERICAN THYROID SOCIETY (LATS) POSITION STATEMENT. ( 30742573 )
2019
48
Subclinical hypothyroidism: When to treat. ( 30742580 )
2019
49
Hypothyroidism and renal impairment: an easily missed diagnosis. ( 30754084 )
2019
50
Short-Term Time Trends in Prescribing Therapy for Hypothyroidism: Results of a Survey of American Thyroid Association Members. ( 30761091 )
2019