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MCID: HYP086
MIFTS: 64

Hypothyroidism

Categories: Endocrine diseases, Rare diseases, Immune diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Hypothyroidism

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MalaCards integrated aliases for Hypothyroidism:

Name: Hypothyroidism 12 76 29 55 6 43 44 15 73
Thyroid Diseases 55 43 73
Thyroid Insufficiency 12
Dysfunction Thyroid 55
Thyroid Dysfunction 73
Thyroid Deficiency 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Endocrine diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 33


Sources

Summaries for Hypothyroidism

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MedlinePlus : 43 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. It is one of your endocrine glands, which make hormones. Thyroid hormones control the rate of many activities in your body. These include how fast you burn calories and how fast your heart beats. All of these activities are your body's metabolism. Thyroid problems include Goiter - enlargement of the thyroid gland Hyperthyroidism - when your thyroid gland makes more thyroid hormones than your body needs Hypothyroidism - when your thyroid gland does not make enough thyroid hormones Thyroid cancer Thyroid nodules - lumps in the thyroid gland Thyroiditis - swelling of the thyroid To diagnose thyroid diseases, doctors use a medical history, physical exam, and thyroid tests. They sometimes also use a biopsy. Treatment depends on the problem, but may include medicines, radioiodine therapy, or thyroid surgery. Dept. of Health and Human Services Office on Women's Health

MalaCards based summary : Hypothyroidism, also known as thyroid diseases, is related to hypothyroidism, congenital, nongoitrous, 2 and hypothyroidism, congenital, nongoitrous, 4. An important gene associated with Hypothyroidism is RET (Ret Proto-Oncogene), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Human Thyroid Stimulating Hormone (TSH) signaling pathway. The drugs Selenium and Iodine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and heart, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Disease Ontology : 12 A thyroid gland disease which involves an underproduction of thyroid hormone.

Wikipedia : 76 Hypothyroidism, also called underactive thyroid or low thyroid, is a disorder of the endocrine system in... more...

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Related Diseases for Hypothyroidism

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Diseases in the Hypothyroidism family:

Congenital Hypothyroidism Central Congenital Hypothyroidism
Hypothyroidism Due to Iodide Transport Defect Hypothyroidism Due to Deficient Transcription Factors Involved in Pituitary Development or Function
Congenital Hypothyroidism Due to Maternal Intake of Antithyroid Drugs Congenital Hypothyroidism Due to Transplacental Passage of Maternal Tsh-Binding Inhibitory Antibodies

Diseases related to Hypothyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 624)
# Related Disease Score Top Affiliating Genes
1 hypothyroidism, congenital, nongoitrous, 2 34.9 NKX2-1 PAX8 SERPINA7 SLC26A4 TG TSHR
2 hypothyroidism, congenital, nongoitrous, 4 34.6 TG TPO TSHB
3 neonatal hypothyroidism 34.6 PAX8 SLC5A5 TG TPO TSHR
4 congenital hypothyroidism 34.3 DUOX2 DUOXA2 GLIS3 IYD NKX2-1 NKX2-5
5 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 34.0 TG TPO
6 pendred syndrome 33.9 DUOX2 PAX8 SLC26A4 TG TPO
7 myxedema 33.8 TG TPO TSHR
8 hashimoto thyroiditis 33.4 RET SLC26A4 TG TPO TSHB TSHR
9 hyperthyroidism 33.2 SERPINA7 TG TPO TRH TSHR
10 subacute thyroiditis 33.1 SERPINA7 TG TPO TSHR
11 graves' disease 33.0 SERPINA7 TG TPO TSHR
12 thyroid ectopia 32.4 NKX2-5 PAX8
13 familial thyroid dyshormonogenesis 32.1 DUOX2 DUOXA2 IYD SLC5A5 TG TPO
14 athyreosis 32.0 NKX2-1 NKX2-5 PAX8 SLC26A4 TG TSHR
15 thyroiditis 31.8 RET SERPINA7 TG TPO TRH TSHB
16 neonatal thyrotoxicosis 31.0 PAX8 TSHR
17 endemic goiter 31.0 SERPINA7 TG TPO TSHB TSHR
18 hyperthyroxinemia 30.9 SERPINA7 TPO TRH TSHR
19 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.9 TG TPO TSHR
20 goiter 30.9 DUOXA2 IYD NKX2-1 PAX8 SERPINA7 SLC26A4
21 thyroid hormone resistance, generalized, autosomal dominant 30.8 SERPINA7 TG TRH
22 plummer's disease 30.7 TG TPO
23 struma ovarii 30.7 NKX2-1 RET TG TSHR
24 nodular goiter 30.7 RET TG TPO TSHR
25 differentiated thyroid carcinoma 30.6 NKX2-1 PAX8 RET TG TPO TSHR
26 multinodular goiter 30.6 NKX2-1 PAX8 SLC26A4 TG TPO TSHR
27 papillary carcinoma 30.4 NKX2-1 PAX8 RET TG TPO TSHR
28 toxic diffuse goiter 30.4 SERPINA7 TG TPO TRH TSHR
29 pernicious anemia 30.4 TG TPO
30 thyroid cancer 30.2 NKX2-1 PAX8 RET SLC26A4 SLC5A5 TG
31 thyroid cancer, nonmedullary, 1 30.2 NKX2-1 PAX8 RET TG
32 hypothyroidism, congenital, nongoitrous, 1 12.4
33 hypothyroidism, central, and testicular enlargement 12.4
34 choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction 12.4
35 central congenital hypothyroidism 12.3
36 diabetes mellitus, neonatal, with congenital hypothyroidism 12.2
37 ectodermal dysplasia, hypohidrotic, with hypothyroidism and ciliary dyskinesia 12.1
38 hypothyroidism, congenital, nongoitrous, 5 12.1
39 postsurgical hypothyroidism 12.1
40 hypothyroidism, congenital, nongoitrous, 6 12.1
41 hypothyroidism, congenital, nongoitrous, 3 12.0
42 muscular pseudohypertrophy-hypothyroidism syndrome 11.9
43 hypothyroidism due to deficient transcription factors involved in pituitary development or function 11.9
44 idiopathic congenital hypothyroidism 11.9
45 iodine hypothyroidism 11.8
46 ectodermal dysplasia, hypohidrotic, with hypothyroidism and agenesis of the corpus callosum 11.7
47 anterior chamber cleavage disorder, cerebellar hypoplasia, hypothyroidism, and tracheal stenosis 11.7
48 hypothyroidism due to iodide transport defect 11.7
49 genetic transient congenital hypothyroidism 11.7
50 congenital hypothyroidism due to maternal intake of antithyroid drugs 11.7

Comorbidity relations with Hypothyroidism via Phenotypic Disease Network (PDN): (show top 50) (show all 156)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Allergic Rhinitis Alzheimer Disease
Anxiety Aortic Valve Disease 1
Atypical Depressive Disorder Autonomic Nervous System Disease
Basilar Artery Insufficiency Benign Essential Hypertension
Bipolar Disorder Borderline Personality Disorder
Bronchiectasis Bronchitis
Bronchopneumonia Celiac Disease 1
Cerebral Atherosclerosis Cerebral Degeneration
Cerebrovascular Disease Chronic Kidney Failure
Chronic Myocardial Ischemia Chronic Pulmonary Heart Disease
Communicating Hydrocephalus Conjunctivitis
Conn's Syndrome Conversion Disorder
Cystitis Decubitus Ulcer
Deficiency Anemia Delusional Disorder
Dependent Personality Disorder Dermatomycosis
Diabetes Insipidus Diabetic Polyneuropathy
Dyshormonogenic Goiter Dyskinesia of Esophagus
Dysthymic Disorder Encephalopathy
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Esophagitis
Exophthalmos Familial Atrial Fibrillation
Female Breast Cancer Female Stress Incontinence
Femoral Vein Thrombophlebitis First-Degree Atrioventricular Block
Gastroesophageal Reflux Generalized Anxiety Disorder

Graphical network of the top 20 diseases related to Hypothyroidism:



Diseases related to Hypothyroidism
Sources

Symptoms & Phenotypes for Hypothyroidism

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MGI Mouse Phenotypes related to Hypothyroidism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.28 RET GLIS3 IGSF1 SLC26A4 NKX2-1 CHD7
2 growth/size/body region MP:0005378 10.22 PAX8 DUOX2 RET GLIS3 IGSF1 NKX2-1
3 homeostasis/metabolism MP:0005376 10.17 PAX8 DUOX2 RET GLIS3 IGSF1 SLC26A4
4 nervous system MP:0003631 9.97 RET GNB1 IGSF1 SLC26A4 NKX2-1 ADNP
5 hearing/vestibular/ear MP:0005377 9.85 PAX8 DUOX2 SLC26A4 CHD7 TSHR TPO
6 limbs/digits/tail MP:0005371 9.73 PAX8 DUOXA2 RET CHD7 TPO TSHR
7 reproductive system MP:0005389 9.61 PAX8 DUOX2 RET SLC26A4 IGSF1 NKX2-1
8 skeleton MP:0005390 9.23 DUOX2 PAX8 DUOXA2 NKX2-1 CHD7 TPO
Sources

Drugs & Therapeutics for Hypothyroidism

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Drugs for Hypothyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 808)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Selenium Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 7782-49-2
2
Iodine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 7553-56-2 807
3
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 9004-61-9 53477741
4
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 68602 5311068
5
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
6
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
7
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
8
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
9
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
10
Nitric Oxide Approved Phase 4,Not Applicable 10102-43-9 145068 160954
11
Nitroprusside Approved, Investigational Phase 4 15078-28-1 11963622
12
Propylthiouracil Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 51-52-5 657298
13
Betamethasone Approved, Vet_approved Phase 4,Phase 3 378-44-9 9782
14
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
15
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 53-03-2 5865
16
Amiodarone Approved, Investigational Phase 4,Phase 3 1951-25-3 2157
17
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
18
Menthol Approved Phase 4,Phase 3,Phase 2,Not Applicable 2216-51-5 16666
19
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 83-43-2 6741
20
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-24-8 5755
21
Hydroxocobalamin Approved Phase 4,Phase 2,Not Applicable 13422-51-0 11953898 44475014
22
Iron Approved Phase 4,Phase 2,Phase 1,Not Applicable 7439-89-6 23925
23
Bexarotene Approved, Investigational Phase 4,Phase 3,Phase 1,Early Phase 1 153559-49-0 82146
24
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 2,Phase 3 198153-51-4 5360545
25
Ribavirin Approved Phase 4,Phase 2,Phase 3 36791-04-5 37542
26
Triamcinolone Approved, Vet_approved Phase 4,Not Applicable 124-94-7 31307
27
Testosterone Approved, Investigational Phase 4,Phase 1,Early Phase 1,Not Applicable 58-22-0 6013
28
Dinoprost Tromethamine Approved, Vet_approved Phase 4,Not Applicable 38562-01-5 5282415
29
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 657-24-9 14219 4091
30
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 525-66-6 4946
31
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
32
Peginterferon alfa-2b Approved Phase 4,Phase 2,Phase 3 99210-65-8, 215647-85-1
33
Sunitinib Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 341031-54-7, 557795-19-4 5329102
34
Liraglutide Approved Phase 4,Phase 3,Phase 2,Not Applicable 204656-20-2 44147092
35
Salmon Calcitonin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 47931-85-1 16129616
36
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 64-17-5 702
37
Somatostatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 38916-34-6, 51110-01-1 53481605
38
Acetylcholine Approved Phase 4,Phase 2,Phase 3 51-84-3 187
39
Citalopram Approved Phase 4,Phase 3,Phase 2,Not Applicable 59729-33-8 2771
40
Leuprolide Approved, Investigational Phase 4,Phase 3 53714-56-0 3911 657181
41
Copper Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 7440-50-8 27099
42
Celecoxib Approved, Investigational Phase 4,Phase 2 169590-42-5 2662
43
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
44
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 1 439-14-5 3016
45
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 50-28-2 5757
46 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 979-32-8
47
Polyestradiol phosphate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 28014-46-2
48
Bimatoprost Approved, Investigational Phase 4,Phase 3 155206-00-1 5311027
49
Ephedrine Approved Phase 4,Phase 3,Phase 2 299-42-3 9294
50
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2 90-82-4 7028

Interventional clinical trials:

(show top 50) (show all 1822)
# Name Status NCT ID Phase Drugs
1 Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism Unknown status NCT02316743 Phase 4 Levothyroxine supplementation
2 Thyroxine Titration Study Unknown status NCT00111735 Phase 4 Thyroxine
3 Thyroid Study Type 2 Diabetes Mellitus (T2DM) Unknown status NCT01379170 Phase 4 Euthyrox (levothyroxine)
4 Selenium Supplementation in Youths With Autoimmune Thyroiditis Unknown status NCT02644707 Phase 4
5 rAd-p53 Gene Therapy for Advanced Malignant Thyroid Tumors Unknown status NCT00902122 Phase 4 rAd-p53 gene;p53 gene therapy
6 Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Unknown status NCT01738243 Phase 4 Hyaluronic Acid Gel injection;Saline injection
7 Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General Anesthesia Unknown status NCT02613806 Phase 4 Dexmeditomidine;normal saline
8 Etoricoxib for Postoperative Pain After Thyroid Surgery Unknown status NCT00935116 Phase 4 etoricoxib
9 Cardiopulmonary Capacity in Elderly With Different Ranges of Serum Thyroid Stimulating Hormone Unknown status NCT01849861 Phase 4 Methimazole
10 Effect of Propofol on Remifentanil-induced Postoperative Hyperalgesia in Patients Undergoing Thyroid Surgery Unknown status NCT01189721 Phase 4 propofol, sevoflurane
11 Clinical Study Investigating the Effect of Sodium Nitroprusside Infusion on Thyroidal Function Unknown status NCT00636584 Phase 4 sodium nitroprusside;placebo
12 The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy Unknown status NCT01056419 Phase 4 Propylthiouracil
13 Total Thyroidectomy With Harmonic Scalpel® Unknown status NCT00385983 Phase 4
14 The Role of Levothyroxine on Goiter With Atypia of Undetermined Significance Unknown status NCT02329379 Phase 4 Levothyroxine
15 Steroids in the Postoperative Transient Hypoparathyroidism Total Thyroidectomy Unknown status NCT02652884 Phase 4 phosphate and betamethasone acetate, 2 mL.;saline 0.9% NaCl
16 Trial Evaluating Use of Arista in Total Thyroidectomy Unknown status NCT02568085 Phase 4
17 Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions Unknown status NCT02190994 Phase 4 Hydrocortisone;Prednisone
18 Effect of Nasal CPAP on Lipid Profile in Patients With Dyslipidaemia and Sleep Apnea Unknown status NCT02557412 Phase 4
19 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
20 Cardiac Resynchronization in Atrial Fibrillation Trial - a Pilot Study Unknown status NCT01850277 Phase 4 Amiodarone;Pharmacotherapy to slow and control ventricular rate
21 Evaluation of the Efficacy and Safety of Levothyroxine in Brain Death Organ Donors: a Randomized Controled Trial Unknown status NCT02211053 Phase 4 Levothyroxine;placebo
22 A Prospective, Randomized Trial of Intravenous Pulse Versus Sequential Steroid Therapy for Patients With Graves' Orbitopathy Unknown status NCT01969019 Phase 4 methylprednisolone, prednisone
23 Effect of Higher Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy Unknown status NCT01761149 Phase 4 Remifentanil
24 Clinical Trial to Evaluate the Efficacy of FITOGYN Versus Placebo on the Vasomotor Symptomatology Associated With Menopause Unknown status NCT01116310 Phase 4 Soy isoflavones (Glycine max L) and red clover extract (Trifolium pretense L);Placebo
25 Thyroid Hormone Replacement for Subclinical Hypothyroidism Completed NCT01660126 Phase 4 Levothyroxine;Placebo
26 Growth Hormone and GnRH Agonist in Adolescents With Acquired Hypothyroidism Completed NCT00206375 Phase 4 Growth hormone;Growth hormone treatment and puberty
27 Effects of L-carnitine on Hypothyroidism Completed NCT01769157 Phase 4 L-carnitine;Placebo
28 Effect of T4-T3 Combination Therapy Versus T4 Monotherapy in Patients With Hypothyroidism Completed NCT00531713 Phase 4 Triiodothyronine
29 Phase 4 Study in Secondary Hypothyroidism: Body Weight Adapted Thyroxin Treatment and Triiodothyronine Supplementation Completed NCT00360074 Phase 4 Thyroxin, Triiodothyronine
30 Study of Radioiodine (131-I) Uptake Following Administration of Thyrogen and Hypothyroid States During Thyroid Hormone Withdrawal. Completed NCT00001730 Phase 4 Thyrogen
31 The TRUST Study - Depression Substudy Completed NCT01853579 Phase 4 Levothyroxine;Placebo
32 Study of Optimal Replacement of Thyroxine in the Elderly Completed NCT01647750 Phase 4 Levothyroxine;Levothyroxine
33 Bioequivalence of Two Levothyroxine Tablet Formulations in Healthy Indian Volunteers Completed NCT01536678 Phase 4 Levothyroxine;Levothyroxine
34 Study to Verify Clinical Utility of Point-of-Care (POC) Thyroid Stimulating Hormone (TSH) Test Kits as Compared to Third Generation TSH Test Kit Completed NCT01921452 Phase 4
35 The TRUST Trial - CardioVascular Imaging ECHO Completed NCT02832960 Phase 4 Levothyroxine;Placebo
36 The TRUST Study - CardioVascular Imaging IMT Completed NCT02832934 Phase 4 Levothyroxine;Placebo
37 Iodine Status of Preschoolers Given Micronutrient Powder for 6 Months Completed NCT02280330 Phase 4
38 Carbohydrate Metabolism Disorder Frequency in Hypertriglyceridemia Induced by Bexarotene of Cutaneous T Cell Lymphoma Completed NCT01569724 Phase 4
39 Short-term Prednisone to Treat STA Study(SPTSS) Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
40 Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction Completed NCT02491008 Phase 4 Levothyroxine;Placebo
41 Safety and Efficacy of Oral Mega Pulse Methylprednisolone in Severe Therapy Resistant Alopecia Areata Completed NCT01167946 Phase 4 methylprednisolone sodium succinate;methylprednisolone sodium succinate;methylprednisolone sodium succinate
42 Long-Term Growth and Skeletal Effects of Early Growth Hormone Treatment in Turner Syndrome Completed NCT00266656 Phase 4 Humatrope
43 A Triple Combination Therapy Study of Boceprevir, Pegasys and Copegus in Previously Untreated Patients With Genotype 1 Chronic Hepatitis C Completed NCT01591460 Phase 4 boceprevir;peginterferon alfa-2a [Pegasys];peginterferon alfa-2a [Pegasys];ribavirin (Copegus];ribavirin (Copegus]
44 Percutaneous Laser Ablation in Benign Thyroid Nodules.Long Term Results Completed NCT00858104 Phase 4
45 Quality of Life, Recombinant TSH (Thyrogen) and Thyroid Cancer Completed NCT00604318 Phase 4 rhTSH
46 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
47 A Comparison of Patch vs. Pill Estrogen Therapy on Testosterone Levels and Thyroid Tests in Menopausal Women Completed NCT00224094 Phase 4 Premarin® (oral) vs. Alora® (transdermal)
48 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
49 Thyroid Medication and Antidepressants for Treating Major Depression Completed NCT00208702 Phase 4 Triiodothyronine;Sertraline
50 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4 Methimazole

Search NIH Clinical Center for Hypothyroidism

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: hypothyroidism

Sources

Genetic Tests for Hypothyroidism

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Genetic tests related to Hypothyroidism:

# Genetic test Affiliating Genes
1 Hypothyroidism 29
Sources

Anatomical Context for Hypothyroidism

About this section

MalaCards organs/tissues related to Hypothyroidism:

41
Thyroid, Testes, Heart, Brain, Eye, Lung, Bone
Sources

Publications for Hypothyroidism

About this section

Articles related to Hypothyroidism:

(show top 50) (show all 3366)
# Title Authors Year
1
Increased Interleukin-23 in Hashimoto's Thyroiditis Disease Induces Autophagy Suppression and Reactive Oxygen Species Accumulation. ( 29434604 )
2018
2
Mean high dose L-thyroxine treatment is efficient and safe to achieve a normal IQ in young adult patients with congenital hypothyroidism. ( 29325045 )
2018
3
A Japanese patient with congenital central hypothyroidism caused by a novel IGSF1 mutation. ( 29425110 )
2018
4
Distal renal tubular acidosis in two children with acquired hypothyroidism. ( 29716758 )
2018
5
Congenital Hypothyroidism. ( 29405999 )
2018
6
Does hypothyroidism augment sun-induced skin damage? ( 29962323 )
2018
7
Prevalence of subclinical hypothyroidism in adults visiting primary health-care setting in Riyadh. ( 29441159 )
2018
8
Incidence of congenital hypothyroidism in China: data from the national newborn screening program, 2013-2015. ( 29715190 )
2018
9
Relation of Subclinical Hypothyroidism is Associated With Cardiovascular Events and All-Cause Mortality in Adults With High Cardiovascular Risk. ( 29980273 )
2018
10
Interaction of HLA-DRB1* alleles and CTLA4 (+49 AG) gene polymorphism in Autoimmune Thyroid Disease. ( 29174716 )
2018
11
Massive pleural and pericardial effusion due to hypothyroidism in a patient with a surgically treated thyroid-stimulating hormone-producing pituitary adenoma. ( 29757110 )
2018
12
The immunological disease continuum of inflammation against self as an explanation for the lack of association between hidradenitis suppurativa and autoimmune thyroid disease. ( 29327479 )
2018
13
Abnormal expression of ephrin-A5 affects brain development of congenital hypothyroidism rats. ( 29762250 )
2018
14
Prevalence of thyroid diseases in familial adenomatous polyposis: a systematic review and meta-analysis. ( 29663106 )
2018
15
Phosphate binders as a cause of hypothyroidism in dialysis patients: practical indications from a review of the literature. ( 29966512 )
2018
16
microRNA-124-3p inhibits the progression of congenital hypothyroidism via targeting programmed cell death protein 6. ( 29805523 )
2018
17
The Combined Effects of Levothyroxine and Low Level Laser Therapy on Wound Healing in Hypothyroidism Male Rat Model. ( 29399303 )
2018
18
Increased risk for inflammatory bowel disease in congenital hypothyroidism supports the existence of a shared susceptibility factor. ( 29977049 )
2018
19
Does initial dosing of levothyroxine in infants with congenital hypothyroidism lead to frequent dose adjustments secondary to iatrogenic hyperthyroidism on follow-up? ( 29715192 )
2018
20
Subclinical Hypothyroidism and the Risk of Cardiovascular Disease and All-Cause Mortality: a Meta-Analysis of Prospective Cohort Studies. ( 29978767 )
2018
21
Permanent Decompensated Congenital Hypothyroidism in Newborns with Whole-Blood Thyroid-Stimulating Hormone Concentrations between 8 and 10 mU/L: The Case for Lowering the Threshold. ( 29804122 )
2018
22
Evaluation of renal function in subclinical hypothyroidism. ( 29403205 )
2018
23
Association of Hypothyroidism with All-cause Mortality: A Cohort Study in an Older Adult Population. ( 29947768 )
2018
24
Two Cases of Transiently Elevated Serum CEA Levels in Severe Hypothyroidism without Goiter. ( 29709954 )
2018
25
Primary Hypothyroidism Presenting as Bilateral Ovarian Torsion. ( 29396948 )
2018
26
Anesthetic considerations in a parturient with renal tubular acidosis and hypothyroidism undergoing cesarean delivery. ( 29029882 )
2018
27
A Novel Missense Mutation in the SLC5A5 Gene in a Sudanese Family with Congenital Hypothyroidism. ( 29759035 )
2018
28
The Protective effect of P7C3 against DNA and neuron damage in rat pups with congenital hypothyroidism. ( 29665652 )
2018
29
Severely low serum magnesium is associated with increased risks of positive anti-thyroglobulin antibody and hypothyroidism: A cross-sectional study. ( 29967483 )
2018
30
Biofortification of Cereals With Foliar Selenium and Iodine Could Reduce Hypothyroidism. ( 29951072 )
2018
31
c-Fos downregulation positively regulates EphA5 expression in a congenital hypothyroidism rat model. ( 29330744 )
2018
32
A 7-year study on the prevalence of congenital hypothyroidism in northern Iran. ( 29881532 )
2018
33
Correlation Between Oral Lichen Planus and Thyroid Disease in China: A Case-Control Study. ( 29967591 )
2018
34
Pituitary 'pseudotumor': an under-recognised complication of undertreated primary hypothyroidism. ( 29950371 )
2018
35
Congenital Hypothyroidism Due to Dyshormonogenesis in 2 Siblings. ( 29450818 )
2018
36
The Effects of De-Whiskering and Congenital Hypothyroidism on The Development of Nitrergic Neurons in Rat Primary Somatosensory and Motor Cortices. ( 29633592 )
2018
37
Fetal goitrous hypothyroidism - easy to recognize, difficult to treat. Is a combined intraamniotic and intravenous L-thyroxine therapy an option? ( 29956299 )
2018
38
Short stature and hypothyroidism in a child with Nail-Patella Syndrome. A case report. ( 29664512 )
2018
39
The genetic characteristics of congenital hypothyroidism in China by comprehensive screening of 21 candidate genes. ( 29650690 )
2018
40
Growth Failure and Excessive Weight Gain in a 10 Year Old Male With Obesity: Approach to Diagnosis, Management, and Treatment of Acquired Hypothyroidism. ( 29971222 )
2018
41
Prevalence of hypothyroidism among patients with isthmus-preserved thyroid lobectomy. ( 29968481 )
2018
42
Massive pericardial effusion without cardiac tamponade due to subclinical hypothyroidism (Hashimoto's disease). ( 29778090 )
2018
43
Genetic and functional analysis of two missense<i>DUOX2</i>mutations in congenital hypothyroidism and goiter. ( 29435108 )
2018
44
Congenital Hypothyroidism Screening in Term Neonates using Umbilical Cord Blood TSH Values. ( 29911045 )
2018
45
Correction to: Metabolic Brain Network Analysis of Hypothyroidism Symptom Based on [<sup>18</sup>F]FDG-PET of Rats. ( 29931430 )
2018
46
Appraisal of clinical practice guidelines on the management of hypothyroidism in pregnancy using the Appraisal of Guidelines for Research and Evaluation II instrument. ( 29445919 )
2018
47
Circulating MiR-146a May be a Potential Biomarker of Coronary Heart Disease in Patients with Subclinical Hypothyroidism. ( 29357324 )
2018
48
The influence of thyroid diseases, diabetes mellitus, primary hyperparathyroidism, vitamin B12 deficiency and other comorbid autoimmune diseases on treatment outcome in patients with rheumatoid arthritis: An exploratory cohort study. ( 29794789 )
2018
49
Hypothyroidism and Hypoparathyroidism in Thalassemia Major Patients: A Study in Sistan and Baluchestan Province, Iran. ( 29868126 )
2018
50
Antidepressant-Resistant Depression in Patients With Comorbid Subclinical Hypothyroidism or High-Normal TSH Levels. ( 29961367 )
2018