MCID: HYP086
MIFTS: 68

Hypothyroidism

Categories: Endocrine diseases, Fetal diseases, Immune diseases, Mental diseases, Metabolic diseases, Neuronal diseases, Rare diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Hypothyroidism

MalaCards integrated aliases for Hypothyroidism:

Name: Hypothyroidism 11 75 28 53 5 41 43 14 16 71 33
Thyroid Diseases 53 41 71
Thyroid Insufficiency 11
Dysfunction Thyroid 53
Thyroid Dysfunction 71
Thyroid Deficiency 11
Thyroid Disease 16

Classifications:



External Ids:

Disease Ontology 11 DOID:1459
ICD9CM 34 244.9
MeSH 43 D007037
NCIt 49 C26800
SNOMED-CT 68 267465007
UMLS 71 C0020676 C0040128 C0348024

Summaries for Hypothyroidism

MedlinePlus: 41 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. It is one of your endocrine glands, which make hormones. Thyroid hormones control the rate of many activities in your body. These include how fast you burn calories and how fast your heart beats. All of these activities are your body's metabolism. Thyroid problems include: Goiter - enlargement of the thyroid gland Hyperthyroidism - when your thyroid gland makes more thyroid hormones than your body needs Hypothyroidism - when your thyroid gland does not make enough thyroid hormones Thyroid cancer Thyroid nodules - lumps in the thyroid gland Thyroiditis - swelling of the thyroid To diagnose thyroid diseases, doctors use a medical history, physical exam, and thyroid tests. They sometimes also use a biopsy. Treatment depends on the problem, but may include medicines, radioiodine therapy, or thyroid surgery. Dept. of Health and Human Services Office on Women's Health

MalaCards based summary: Hypothyroidism, also known as thyroid diseases, is related to congenital hypothyroidism and hypothyroidism, congenital, nongoitrous, 1. An important gene associated with Hypothyroidism is RET (Ret Proto-Oncogene), and among its related pathways/superpathways are Thyroid stimulating hormone (TSH) signaling pathway and Thyroid hormones production and peripheral downstream signaling effects. The drugs Nitroprusside and Nitric Oxide have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and lymph node, and related phenotypes are Resistant to vaccinia virus (VACV-A4L) infection and homeostasis/metabolism

Disease Ontology: 11 A thyroid gland disease which involves an underproduction of thyroid hormone.

Wikipedia: 75 Hypothyroidism (also called underactive thyroid, low thyroid or hypothyreosis) is a disorder of the... more...

Related Diseases for Hypothyroidism

Diseases in the Hypothyroidism family:

Congenital Hypothyroidism Central Congenital Hypothyroidism
Hypothyroidism Due to Iodide Transport Defect Rare Adult Hypothyroidism
Transient Congenital Hypothyroidism Rare Hypothyroidism
Primary Congenital Hypothyroidism Hypothyroidism Due to Deficient Transcription Factors Involved in Pituitary Development or Function
Congenital Hypothyroidism Due to Maternal Intake of Antithyroid Drugs Transient Congenital Hypothyroidism Due to Maternal Factor
Transient Congenital Hypothyroidism Due to Neonatal Factor Congenital Hypothyroidism Due to Transplacental Passage of Tsh-Binding Inhibitory Antibodies
Congenital Hypothyroidism Due to Developmental Anomaly

Diseases related to Hypothyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2030)
# Related Disease Score Top Affiliating Genes
1 congenital hypothyroidism 33.7 TSHR TSHB TRHR TRH TPO TG
2 hypothyroidism, congenital, nongoitrous, 1 33.6 TSHR TSHB TG PAX8 IYD GLIS3
3 hypothyroidism, congenital, nongoitrous, 2 33.6 TSHR TG SLC26A4 PAX8 NKX2-1
4 hypothyroidism, central, with testicular enlargement 33.2 TSHB TRHR TRH
5 diabetes mellitus, neonatal, with congenital hypothyroidism 33.1 SLC5A5 IYD GLIS3
6 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 33.1 TSHR SLC26A4 PAX8 NKX2-1 IYD
7 hypothyroidism, congenital, nongoitrous, 4 33.1 TSHB TPO TG
8 pendred syndrome 33.0 TPO TG SLC5A5 SLC26A4 PAX8 IYD
9 hyperthyroidism 32.9 TSHR TRHR TRH TPO TG SERPINA7
10 postsurgical hypothyroidism 32.8 TSHR TPO TG
11 hashimoto thyroiditis 32.8 TSHR TPO TG SLC26A4 SERPINA7 RET
12 thyroid dyshormonogenesis 1 32.7 SLC5A5 PAX8
13 myxedema 32.7 TSHR TSHB TPO TG SERPINA7
14 iodine hypothyroidism 32.6 TSHR TPO TG
15 thyroid dyshormonogenesis 2a 32.6 TSHR TPO TG RET PAX8 NKX2-1
16 thyroid dyshormonogenesis 4 32.6 IYD DIO3
17 familial thyroid dyshormonogenesis 32.5 TPO TG SLC5A5 SERPINA7 IYD DIO3
18 graves disease 1 32.5 TSHR TRH TPO TG SLC5A5 SERPINA7
19 athyreosis 32.4 TSHR SLC26A4 PAX8 NKX2-5 NKX2-1
20 subacute thyroiditis 32.2 TSHR TPO TG SERPINA7
21 thyroid ectopia 32.2 PAX8 NKX2-5
22 goiter 32.1 TSHR TRH TPO TG SLC5A5 SLC26A4
23 thyroiditis 32.0 TSHR TSHB TPO TG SERPINA7 RET
24 graves' disease 32.0 TSHR TPO TG SERPINA7 PAX8
25 nontoxic goiter 31.4 TSHR TPO TG SERPINA7
26 adenoma 31.3 TSHR TSHB TRH TG RET
27 endemic goiter 31.2 TSHR TSHB TRH TPO TG SLC5A5
28 euthyroid sick syndrome 31.2 TRH TG SERPINA7 DIO3
29 turner syndrome 31.1 TPO TG SERPINA7
30 nodular goiter 31.1 TSHR TPO TG SLC5A5 RET
31 multinodular goiter 31.0 TSHR TRH TPO TG SLC5A5 SLC26A4
32 thyroid hormone resistance, generalized, autosomal dominant 31.0 TSHR TSHB TRH TG SERPINA7
33 differentiated thyroid carcinoma 31.0 RET PAX8 NKX2-1
34 celiac disease 1 30.9 TPO TG STAT1 IFNA1
35 graves ophthalmopathy 30.9 TSHR TG
36 plummer's disease 30.9 TSHR TPO TG SERPINA7
37 goiter, multinodular 1, with or without sertoli-leydig cell tumors 30.9 TPO TG
38 hyperthyroxinemia 30.8 TSHR TPO SERPINA7
39 thyroid crisis 30.8 TSHR TPO TG SERPINA7
40 neonatal thyrotoxicosis 30.7 TSHR TG DIO3
41 papillary carcinoma 30.6 TSHR TPO TG RET PAX8 NKX2-1
42 dyshormonogenic goiter 30.6 TG SLC5A5 SLC26A4 IYD
43 thyroid hormone resistance, selective pituitary 30.6 TSHB TRH TG SERPINA7
44 hypothalamic disease 30.6 TSHB TRH
45 autoimmune polyendocrine syndrome 30.6 TG STAT1 IFNA1
46 thyroid cancer, nonmedullary, 2 30.6 TSHR TG PAX8
47 suppurative thyroiditis 30.5 TSHR TPO TG SLC5A5
48 hypotropia 30.5 TSHR TPO
49 papillary thyroid microcarcinoma 30.4 TG NKX2-1
50 thyroid gland anaplastic carcinoma 30.4 TSHR TPO TG SLC5A5 SLC26A4 RET

Comorbidity relations with Hypothyroidism via Phenotypic Disease Network (PDN): (show top 50) (show all 152)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Allergic Rhinitis Alzheimer Disease, Familial, 1
Anxiety Aortic Valve Disease 1
Atypical Depressive Disorder Autonomic Nervous System Disease
Basilar Artery Insufficiency Benign Essential Hypertension
Bipolar Disorder Borderline Personality Disorder
Bronchiectasis Bronchitis
Bronchopneumonia Celiac Disease 1
Cerebral Atherosclerosis Cerebral Degeneration
Cerebrovascular Disease Chronic Kidney Disease
Chronic Pulmonary Heart Disease Communicating Hydrocephalus
Congenital Hypothyroidism Conjunctivitis
Conn's Syndrome Conversion Disorder
Cystitis Decubitus Ulcer
Deficiency Anemia Delusional Disorder
Dependent Personality Disorder Dermatomycosis
Diabetes Insipidus Diabetic Polyneuropathy
Dyshormonogenic Goiter Dyskinesia of Esophagus
Dysthymic Disorder Encephalopathy
Epilepsy, Focal, with Speech Disorder and with or Without Impaired Intellectual Development Esophagitis
Familial Atrial Fibrillation Female Breast Cancer
Female Stress Incontinence Femoral Vein Thrombophlebitis
First-Degree Atrioventricular Block Gastroesophageal Reflux
Generalized Anxiety Disorder Generalized Atherosclerosis

Graphical network of the top 20 diseases related to Hypothyroidism:



Diseases related to Hypothyroidism

Symptoms & Phenotypes for Hypothyroidism

GenomeRNAi Phenotypes related to Hypothyroidism according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Resistant to vaccinia virus (VACV-A4L) infection GR00351-A-1 9.17 GLIS3 GNB1 IFNA1 RET SERPINA7 SLC26A4

MGI Mouse Phenotypes related to Hypothyroidism:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.33 CHD7 DIO3 GLIS3 NKX2-1 NKX2-5 PAX8
2 growth/size/body region MP:0005378 10.31 CHD7 DIO3 GLIS3 GNB1 NKX2-1 NKX2-5
3 nervous system MP:0003631 10.27 CHD7 GNB1 NKX2-1 NKX2-5 PAX8 RET
4 endocrine/exocrine gland MP:0005379 10.21 CHD7 GLIS3 NKX2-1 NKX2-5 PAX8 RET
5 limbs/digits/tail MP:0005371 10.02 CHD7 PAX8 RET STAT1 TG TPO
6 cellular MP:0005384 10 CHD7 DIO3 GLIS3 GNB1 NKX2-1 NKX2-5
7 hearing/vestibular/ear MP:0005377 9.98 CHD7 PAX8 SLC26A4 SLC5A5 TG TPO
8 behavior/neurological MP:0005386 9.97 CHD7 GNB1 NKX2-1 PAX8 RET SLC26A4
9 digestive/alimentary MP:0005381 9.92 CHD7 NKX2-1 NKX2-5 RET SLC26A4 STAT1
10 reproductive system MP:0005389 9.65 CHD7 DIO3 NKX2-1 PAX8 RET SLC26A4
11 skeleton MP:0005390 9.36 CHD7 GNB1 NKX2-1 PAX8 SLC26A4 SLC5A5

Drugs & Therapeutics for Hypothyroidism

Drugs for Hypothyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 381)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitroprusside Approved, Investigational Phase 4 15078-28-1 11963622
2
Nitric Oxide Approved Phase 4 10102-43-9 145068
3
Hydroxocobalamin Approved Phase 4 13422-51-0 15589840 44475014
4
Levoleucovorin Approved, Experimental, Investigational Phase 4 68538-85-2, 58-05-9, 73951-54-9 149436 6006
5
Rabeprazole Approved, Investigational Phase 4 117976-89-3, 117976-90-6 5029
6
Pantoprazole Approved Phase 4 102625-70-7, 138786-67-1 4679
7
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6 9578005
8
Esomeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6, 119141-88-7 9568614 4594
9
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
10
Parathyroid hormone Approved, Investigational Phase 4 9002-64-6
11
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
12
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
13
Prednisolone Approved, Vet_approved Phase 4 50-24-8 4894 5755
14
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
15
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5 1875
16
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 4159 6741
17
Codeine Approved, Illicit Phase 4 76-57-3, 6854-40-6 5284371 5362471
18
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
19
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
20
Tramadol Approved, Investigational Phase 4 27203-92-5 33741 5523
21
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
22
Magnesium sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9
23
Metformin Approved Phase 4 1115-70-4, 657-24-9 4091
24
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
25
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
26
Leuprolide Approved, Investigational Phase 4 53714-56-0 657181
27
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
28
Tannic acid Approved Phase 4 1401-55-4 16129878 16129778
29
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
30
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 24892734 16212801 44176380
31
D-Tyrosine Approved, Experimental, Investigational, Nutraceutical Phase 4 133585-56-5, 60-18-4, 556-02-5 1153 6057
32
(3-Carboxy-2-(R)-Hydroxy-Propyl)-Trimethyl-Ammonium Experimental Phase 4 461-06-3
33
Cobalamin Experimental Phase 4 13408-78-1 6857388
34
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7 4897
35 Carboxymethylcellulose Sodium Phase 4
36 Vasodilator Agents Phase 4
37 Vitamin B12 Phase 4
38 Vitamin B 12 Phase 4
39 Anti-Ulcer Agents Phase 4
40 Antacids Phase 4
41 Proton Pump Inhibitors Phase 4
42 Gastrointestinal Agents Phase 4
43 Antineoplastic Agents, Hormonal Phase 4
44 Antiemetics Phase 4
45
Methylprednisolone Acetate Phase 4 584547
46 Antitussive Agents Phase 4
47 Methylene diphosphonate Phase 4
48 Diphosphonates Phase 4
49 Neuroprotective Agents Phase 4
50 Technetium Tc 99m Medronate Phase 4

Interventional clinical trials:

(show top 50) (show all 1014)
# Name Status NCT ID Phase Drugs
1 The Beneficial Effect of L-Thyroxine Long -Term Replacement on Lipid Profiles and Atherosclerosis in Subclinical Hypothyroidism: A Prospective Study Unknown status NCT01831869 Phase 4 L-thyroxine
2 Efficacy and Safety of Levothyroxine (L-T4) Replacement on Exercise Capability in Chronic Systolic Heart Failure Patients With Subclinical Hypothyroidism: A 24-week, Multi-center, Open Label, Randomized, Parallel Group Trial Unknown status NCT03096613 Phase 4 Levothyroxine
3 What is the Optimal Serum TSH Concentration During Thyroxine Treatment for Primary Hypothyroidism? Effects of Fine Titration of Thyroxine Dosage on Wellbeing, Quality of Life and Cognitive Function Unknown status NCT00111735 Phase 4 Thyroxine
4 Beneficial Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism Unknown status NCT02316743 Phase 4 Levothyroxine supplementation
5 Thyroid Hormone Replacement for Hypothyroidism and Acute Myocardial Infarction Unknown status NCT02512978 Phase 4 Levothyroxine
6 Randomized Crossover Trial for the Evaluation of the Possible Effects in the Intestine of Two Different Pharmaceutical Forms of L - Thyroxine in Patients With Primary Acquired Hypothyroidism Unknown status NCT02917863 Phase 4 L-Thyroxine (tablet, per os);L-Thyroxine (oral drops, solution)
7 Effects of Thyroid Hormone Treatment on Mitochondrial Function, Ectopic Fat Accumulation, Insulin Sensitivity and Brown Adipose Tissue in Type 2 Diabetes Mellitus Unknown status NCT01379170 Phase 4 Euthyrox (levothyroxine)
8 Does Sodium Nitroprusside Infusion Affect Thyroidal Function in Patients Undergoing Coronary Artery Bypass Grafting, a Prospective Randomized Clinical Trial. Unknown status NCT00636584 Phase 4 sodium nitroprusside;placebo
9 Total Thyroidectomy With Harmonic Scalpel® Versus Standard Surgery. Open Multicentric Randomized Controlled Trial Unknown status NCT00385983 Phase 4
10 The Use of Lu177 in the Treatment of Progressive and Unresectable Metastatic Medullary Thyroid Cancer Unknown status NCT01915485 Phase 4
11 Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General anesthesia---a Randomized Control Double-Blind Clinical Trial Unknown status NCT02613806 Phase 4 Dexmeditomidine;normal saline
12 Efficacy of Dexmedetomidine for Cough Suppression During Anesthetic Emergence in Patients Undergoing Thyroid Surgery: A Randomized, Double Blinded, Controlled Trial Unknown status NCT03312413 Phase 4 Dexmedetomidine Hydrochloride;Normal Saline
13 Open-Label, Multi-Center, Randomized, Active-Controlled, Phase 4 Study of rAd-p53 Gene Mono-Therapy, With Concurrent Radioactive Iodine , or Combination With Surgery in Subjects With Advanced Malignant Thyroid Tumors Unknown status NCT00902122 Phase 4 rAd-p53 gene;p53 gene therapy
14 Thyroid Hormone Replacement for Subclinical Hypothyroidism (TRUST) - Subanalysis on Subclinical Hypothyroidism and Depression Completed NCT01853579 Phase 4 Levothyroxine;Placebo
15 Evaluation of Long-term Benefit-risk Profile of Levothyroxine Treatment in Children With Congenital Hypothyroidism: Influence of Initial Levothyroxine Dose on Neurodevelopmental, Growth, Cardiovascular and Skeletal Outcomes Completed NCT05371262 Phase 4 Levothyroxin
16 The Effect of Thyroid Hormone Therapy on Muscle Mass and Function in Older Adults With Subclinical Hypothyroidism - a Substudy of TRUST and IEMO Trials Completed NCT04354896 Phase 4 Levothyroxin;Placebo
17 Effect of T4-T3 Combination Therapy Versus T4 Monotherapy in Patients With Hypothyroidism,a Double Blind Randomized Cross-Over Study. Completed NCT00531713 Phase 4 Triiodothyronine
18 Assessing Quality of Life Changes Using Calcitonin in Patients With Hypothyroidism on Biochemical Replacement With Levothyroxine Completed NCT03342001 Phase 4 Calcitonin
19 Effect of Thyroid Hormone Replacement on Fatigability in Untreated Older Adults With Subclinical Hypothyroidism Completed NCT02500342 Phase 4 Levothyroxine;Placebo
20 Neurocognitive and Metabolic Effects of Mild Hypothyroidism Completed NCT00565864 Phase 4 L-thyroxine (L-T4)
21 A Randomised, Controlled, Crossover Study: Treatment With Thyroxin Compared to Thyroxin + Triiodothyronin in Patients With Secondary Hypothyroidism Completed NCT00360074 Phase 4 Thyroxin, Triiodothyronine
22 Multi-modal Effects of Thyroid Hormone Replacement for Untreated Older Adults With Subclinical Hypothyroidism; a Randomised Placebo-controlled Trial Completed NCT01660126 Phase 4 Levothyroxine;Placebo
23 Impact of Thyroid Hormone Replacement on Progression of Atherosclerosis : a Randomized Placebo-Controlled Trial in Older Adults With Subclinical Hypothyroidism. Completed NCT02832934 Phase 4 Levothyroxine;Placebo
24 Single-center, Randomized, Double-Blinded, Comparative Study of the Effectiveness of L-carnitine in Patients'Fatigue Degree Changing With Hypothyroidism Who Take Levothyroxine Completed NCT01769157 Phase 4 L-carnitine;Placebo
25 Impact of Thyroid Hormone Replacement on Cardiac Function: a Randomized Placebo-Controlled Trial in Older Adults With Subclinical Hypothyroidism Completed NCT02832960 Phase 4 Levothyroxine;Placebo
26 A Single-center Interventional Study to Verify Clinical Utility of the Quantitative and the Qualitative POC TSH Test Kits Compared With the Third Generation TSH Test Kit Completed NCT01921452 Phase 4
27 Iodine Intake & Status of Preschoolers Given Micronutrient Powder for 6 Months Completed NCT02280330 Phase 4
28 An Open-label Therapeutic Efficacy Study of Tirosint (Levothyroxine Sodium) Capsules in Thyroidectomized Patients Taking Proton Pump Inhibitors Completed NCT03094416 Phase 4 levothyroxine sodium capsule;Proton pump inhibitor (PPI);Levothyroxine Sodium (LT4) Tablets
29 A Dosimetry Study of Radioiodine (131-I) Uptake Following the Administration of Thyrogen and Hypothyroid States During Thyroid Hormone Withdrawal Completed NCT00001730 Phase 4 Thyrogen
30 Study of Optimal Replacement of Thyroxine in the Elderly (SORTED) SORTED 1 - a Randomised Controlled Trial (Pilot Study), SORTED 2 - Qualitative Interviews, SORTED 3 - Retrospective Cohort Completed NCT01647750 Phase 4 Levothyroxine
31 Bioequivalence of Two Levothyroxine Tablet Formulations in Healthy Indian Volunteers: A Single-dose, Randomized, Open-label, Crossover Study Completed NCT01536678 Phase 4 Levothyroxine
32 Randomized Controlled Trial of Preoperative Steroids in Autoimmune Thyroid Disease Completed NCT04542278 Phase 4 Prednisone
33 Minimizing Narcotic Analgesics After Thyroid or Parathyroid Surgery Completed NCT03469310 Phase 4 Acetaminophen 500Mg Cap;Tylenol #3 Oral Tablet;Tramadol
34 Multicentric Randomized Controlled Study of Percutaneous Laser Ablation Versus Follow Up in Benign Thyroid Nodules. Long Term Results Completed NCT00858104 Phase 4
35 Is the Routine Pressure Dressing After Thyroidectomy Necessary? A Prospective Randomized Controlled Study Completed NCT00400465 Phase 4
36 Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction: a Prospective Evaluation and Impact of Treatment Completed NCT02491008 Phase 4 Levothyroxine;Placebo
37 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
38 Is it Possible to Increase Quality of Life, Using Recombinant TSH Instead of Withdrawal of Thyroid Hormone Treatment, Before Iodine Uptake in Patients With Thyroid Cancer? Completed NCT00604318 Phase 4 rhTSH
39 Diagnostic Accuracy Study of Indocyanine Green for Parathyroid Perfusion Assessment Completed NCT03969108 Phase 4 Indocyanine Green
40 A Double-masked, Methylprednisolone-control, Efficacy and Safety Study of 99Tc-MDP for Thyroid Associated Ophthalmopathy. Completed NCT03948191 Phase 4 Methylprednisolone;99Tc-MDP(99Technetium-Methylenediphosphonate Injection)
41 A Randomized Comparative Study Between Liquid (Tirosint®-SOL) and Tablet Formulations of Levothyroxine in Neonates and Infants With Congenital Hypothyroidism Recruiting NCT05228184 Phase 4 Tirosint®-SOL;Levothyroxine Sodium
42 Type 2 Deiodinase Gene Polymorphism and the Treatment of Hypothyroidism Caused Recruiting NCT05247476 Phase 4 L-T4;L-T4+T3 (thyroid tablet)
43 Effect of Thyroid Replacement Therapy on Thyroid Structure in Patients With Subclinical Hypothyroidism Recruiting NCT04953195 Phase 4 Levothyroxine Sodium Tablets
44 A Prospective, Multicenter Observational Study to Evaluate Thyroid Function of Pediatric Subjects From Birth to 3 Years Exposed to ISOVUE® (Iopamidol Injection) Recruiting NCT03779906 Phase 4 Isovue
45 Comparison of Levothyroxine Formulation in Hypothyroid Patients With Enteral Feeding Recruiting NCT04878614 Phase 4 Levothyroxine Tablet;Levothyroxine Sodium
46 Intravenous Or Topical Lidocaine And Neuromonitoring in Thyroid Surgery (IOLANT Study) Recruiting NCT04574947 Phase 4 Intravenous lidocaine;Intravenous placebo
47 Effect of Tramadol on Postoperative Sore Throat in Thyroid Surgery Under General Anesthesia With Endotracheal Intubation: A Randomized Controlled Trial Recruiting NCT04991493 Phase 4 Tramadol hydrochloride
48 Discontinuation of Levothyroxine Therapy for Patients With Subclinical Hypothyroidism: a Pilot Randomized, Double-blinded, Placebo-controlled Study Active, not recruiting NCT04288115 Phase 4 Levothyroxine
49 Effects of Long-term L-thyroxine Replacement on Serum Lipid and Atherosclerosis in Patients With Hypothyroidism Active, not recruiting NCT01848171 Phase 4 L-thyroxine
50 A Phase 4, Randomized, Double-masked, Placebo-controlled, Multicenter Trial to Evaluate the Efficacy and Safety of TEPEZZA® in Treating Patients With Chronic (Inactive) Thyroid Eye Disease Active, not recruiting NCT04583735 Phase 4 Placebo

Search NIH Clinical Center for Hypothyroidism

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Kelp preparation

Cochrane evidence based reviews: hypothyroidism

Genetic Tests for Hypothyroidism

Genetic tests related to Hypothyroidism:

# Genetic test Affiliating Genes
1 Hypothyroidism 28

Anatomical Context for Hypothyroidism

Organs/tissues related to Hypothyroidism:

MalaCards : Thyroid, Heart, Lymph Node, Eye, Pituitary, Brain, Breast

Publications for Hypothyroidism

Articles related to Hypothyroidism:

(show top 50) (show all 43193)
# Title Authors PMID Year
1
Age-specific serum thyrotropin reference range for the diagnosis of subclinical hypothyroidism and its association with lipid profiles in the elderly population. 62 41
36463291 2022
2
Epworth sleepiness scale is associated with hypothyroidism in male patients with obstructive sleep apnea. 62 41
36465644 2022
3
Supplementation with myo-inositol and Selenium improves the clinical conditions and biochemical features of women with or at risk for subclinical hypothyroidism. 62 41
36465640 2022
4
Masked CKD in hyperthyroidism and reversible CKD status in hypothyroidism. 62 41
36425466 2022
5
Association of coal mine dust lung disease with Nodular thyroid disease in coal miners: A retrospective observational study in China. 62 41
36388340 2022
6
Whole-genome sequencing of patients with rare diseases in a national health system. 5
32581362 2020
7
Endocrine system after 2 years of COVID-19 vaccines: A narrative review of the literature. 41
36440218 2022
8
Genetics and phenomics of hypothyroidism and thyroid dys- and agenesis due to PAX8 and TTF1 mutations. 53 62
20302910 2010
9
Genetics and phenomics of hypothyroidism and goiter due to thyroglobulin mutations. 53 62
20093166 2010
10
Calcitonin screening and pentagastrin testing: predictive value for the diagnosis of medullary carcinoma in nodular thyroid disease. 53 62
20332126 2010
11
Runx2 deficiency in mice causes decreased thyroglobulin expression and hypothyroidism. 53 62
20375239 2010
12
Congenital hypothyroidism in a kitten resulting in decreased IGF-I concentration and abnormal liver function tests. 53 62
20223692 2010
13
Genetics and phenomics of hypothyroidism and goiter due to TPO mutations. 53 62
20153806 2010
14
Genetics and phenomics of hypothyroidism and goiter due to NIS mutations. 53 62
20153805 2010
15
Four patients with hypothyroid Graves' disease. 53 62
20421660 2010
16
Dual oxidase, hydrogen peroxide and thyroid diseases. 53 62
20407074 2010
17
Biallelic p.R2223H mutation in the thyroglobulin gene causes thyroglobulin retention and severe hypothyroidism with subsequent development of thyroid carcinoma. 53 62
20089614 2010
18
Turner syndrome and schizophrenia: a further hint for the role of the X-chromosome in the pathogenesis of schizophrenic disorders. 53 62
20218787 2010
19
Molecular analysis of congenital goitres with hypothyroidism caused by defective thyroglobulin synthesis. Identification of a novel c.7006C>T [p.R2317X] mutation and expression of minigenes containing nonsense mutations in exon 7. 53 62
19438905 2010
20
Environmental pollutants and the thyroid. 53 62
19942155 2009
21
Broad clinical involvement in a family affected by the fragile X premutation. 53 62
19996900 2009
22
Diagnosis and discrimination of autoimmune Graves' disease and Hashimoto's disease using thyroid-stimulating hormone receptor-containing recombinant proteoliposomes. 53 62
19914592 2009
23
Panhypopituitarism due to metastases to the hypothalamus and the pituitary resulting from primary breast cancer: a case report and review of the literature. 53 62
19933072 2009
24
Thyrotropin-stimulating hormone receptor gene analysis in pediatric patients with non-autoimmune subclinical hypothyroidism. 53 62
19820021 2009
25
Congenital leptin deficiency and thyroid function. 53 62
19889232 2009
26
GH replacement in adults: interactions with other pituitary hormone deficiencies and replacement therapies. 53 62
19684055 2009
27
[Clinical significance of apolipoprotein B-48 (apoB-48) in patients with thyroid disease]. 53 62
20030174 2009
28
Radioiodine ablation: when and how. 53 62
19910900 2009
29
More hypothyroidism and less hyperthyroidism with sufficient iodine nutrition compared to mild iodine deficiency--a comparative population-based study of older people. 53 62
19762181 2009
30
Subclinical hypothyroidism and autoimmune thyroiditis in pregnancy--a study in south Indian subjects. 53 62
20329425 2009
31
Final diagnosis in children with subclinical hypothyroidism and mutation analysis of the thyroid peroxidase gene (TPO). 53 62
19960894 2009
32
The p.A2215D thyroglobulin gene mutation leads to deficient synthesis and secretion of the mutated protein and congenital hypothyroidism with wide phenotype variation. 53 62
19509106 2009
33
Ovarian hyper-stimulation syndrome after spontaneous conception. 53 62
19499413 2009
34
Subclinical hypothyroidism in children and adolescents: a wide range of clinical, biochemical, and genetic factors involved. 53 62
19417038 2009
35
[Sarcoidosis associated with hypothyroidism due to thyrotropin-receptor blocking antibodies]. 53 62
18930567 2009
36
[An investigation of BRAF mutation in papillary thyroid carcinoma and its clinical value]. 53 62
19504446 2009
37
Growth hormone/insulin-like growth factor axis in patients with subclinical thyroid dysfunction. 53 62
19111490 2009
38
Type 2 iodothyronine deiodinase in skeletal muscle: effects of hypothyroidism and fasting. 53 62
19293265 2009
39
Effects of thyroxine replacement on serum creatinine and cystatin C in patients with primary and central hypothyroidism. 53 62
19529992 2009
40
TSH receptor - autoantibody interactions. 53 62
19530271 2009
41
[Sodium-iodine symporter in thyroid, normal and cancer tissues and its relation to nuclear medicine and to gene cloning treatment]. 53 62
19675882 2009
42
Serum leptin in overt and subclinical hypothyroidism: effect of levothyroxine treatment and relationship to menopausal status and body composition. 53 62
19415994 2009
43
Persistence of goitre in children post-salt iodization in Islamic Republic of Iran: autoimmune status. 53 62
19731774 2009
44
Evolution of sonographic appearance of the thyroid gland in children with Hashimoto's thyroiditis. 53 62
19554808 2009
45
Mainly the younger hypothyroid patients are referred to hospital--evidence for referral bias. 53 62
18945587 2009
46
Influence of iodide excess and interferon-gamma on human primary thyroid cell proliferation, thyroglobulin secretion, and intracellular adhesion molecule-1 and human leukocyte antigen-DR expression. 53 62
19265500 2009
47
Thyroid function and changes in ultrasound morphology during antiviral therapy with pegylated interferon and ribavirin in patients with chronic hepatitis C. 53 62
19175874 2009
48
Cardiac troponin T is not increased in patients with hypothyroidism. 53 62
19356187 2009
49
An inactivating mutation within the first extracellular loop of the thyrotropin receptor impedes normal posttranslational maturation of the extracellular domain. 53 62
18927215 2009
50
Effects of combined interferon alpha and ribavirin therapy on thyroid functions in patients with chronic hepatitis C. 53 62
19208310 2009

Variations for Hypothyroidism

ClinVar genetic disease variations for Hypothyroidism:

5 (show all 16)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 GNB1 NM_002074.5(GNB1):c.239T>C (p.Ile80Thr) SNV Pathogenic
208722 rs752746786 GRCh37: 1:1737942-1737942
GRCh38: 1:1806503-1806503
2 RET NM_020975.6(RET):c.2753T>C (p.Met918Thr) SNV Pathogenic
13919 rs74799832 GRCh37: 10:43617416-43617416
GRCh38: 10:43121968-43121968
3 CHD7 NM_017780.4(CHD7):c.6892C>T (p.Gln2298Ter) SNV Pathogenic
374090 rs1057518891 GRCh37: 8:61767038-61767038
GRCh38: 8:60854479-60854479
4 STAT1 NM_007315.4(STAT1):c.1154C>T (p.Thr385Met) SNV Pathogenic
Pathogenic
144006 rs587777630 GRCh37: 2:191851647-191851647
GRCh38: 2:190986921-190986921
5 ADNP NM_001282531.3(ADNP):c.2188C>T (p.Arg730Ter) SNV Likely Pathogenic
279598 rs886041116 GRCh37: 20:49509063-49509063
GRCh38: 20:50892526-50892526
6 POGZ NM_015100.4(POGZ):c.402_409dup (p.His137fs) DUP Likely Pathogenic
373957 rs1057518799 GRCh37: 1:151403191-151403192
GRCh38: 1:151430715-151430716
7 TG NM_003235.5(TG):c.5804del (p.Asn1935fs) DEL Likely Pathogenic
689597 rs1587618417 GRCh37: 8:133980155-133980155
GRCh38: 8:132967910-132967910
8 SLC33A1 NM_004733.4(SLC33A1):c.963+1G>A SNV Likely Pathogenic
812763 rs1266904735 GRCh37: 3:155560220-155560220
GRCh38: 3:155842431-155842431
9 SLC26A4 NM_000441.2(SLC26A4):c.1301C>A (p.Ala434Asp) SNV Uncertain Significance
591607 rs1035397261 GRCh37: 7:107334885-107334885
GRCh38: 7:107694440-107694440
10 overlap with 3 genes GRCh37/hg19 6q25.3(chr6:156772218-157870875)x3 CN GAIN Uncertain Significance
523303 GRCh37: 6:156772218-157870875
GRCh38:
11 HUWE1 NM_031407.7(HUWE1):c.6485G>C (p.Arg2162Pro) SNV Uncertain Significance
523539 rs1556948950 GRCh37: X:53596615-53596615
GRCh38: X:53569655-53569655
12 TSHR NM_000369.5(TSHR):c.202C>T (p.Pro68Ser) SNV Uncertain Significance
437071 rs142063461 GRCh37: 14:81528523-81528523
GRCh38: 14:81062179-81062179
13 SCNN1A NM_001038.6(SCNN1A):c.1427G>A (p.Arg476Gln) SNV Uncertain Significance
598965 rs72657556 GRCh37: 12:6458505-6458505
GRCh38: 12:6349339-6349339
14 PAX8 NM_003466.4(PAX8):c.1011del (p.Val339fs) DEL Uncertain Significance
598954 rs1558700308 GRCh37: 2:113993047-113993047
GRCh38: 2:113235470-113235470
15 TG NM_003235.5(TG):c.2549T>A (p.Leu850Gln) SNV Uncertain Significance
1708411 GRCh37: 8:133900601-133900601
GRCh38: 8:132888356-132888356
16 CR1 NM_000651.6(CR1):c.6283C>A (p.His2095Asn) SNV Uncertain Significance
812547 rs1571590802 GRCh37: 1:207783021-207783021
GRCh38: 1:207609676-207609676

Expression for Hypothyroidism

Search GEO for disease gene expression data for Hypothyroidism.

Pathways for Hypothyroidism

GO Terms for Hypothyroidism

Biological processes related to Hypothyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 retina development in camera-type eye GO:0060041 9.93 RET GNB1 CHD7
2 positive regulation of multicellular organism growth GO:0040018 9.8 TSHR DIO3 CHD7
3 thyroid hormone generation GO:0006590 9.8 TPO TG SLC5A5
4 cellular response to gonadotropin stimulus GO:0071371 9.73 SLC5A5 PAX8
5 hormone biosynthetic process GO:0042446 9.73 DIO3 TG TPO
6 thyroid-stimulating hormone signaling pathway GO:0038194 9.67 TSHR PAX8
7 thyroid gland development GO:0030878 9.56 TG PAX8 NKX2-5 NKX2-1
8 thyroid hormone metabolic process GO:0042403 9.55 TG IYD DIO3
9 iodide transport GO:0015705 9.1 TG SLC5A5 SLC26A4

Molecular functions related to Hypothyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.63 STAT1 PAX8 NKX2-5 NKX2-1 GLIS3
2 iodide transmembrane transporter activity GO:0015111 9.26 SLC5A5 SLC26A4
3 thyroid-stimulating hormone receptor activity GO:0004996 8.92 TSHR PAX8

Sources for Hypothyroidism

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....