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MCID: HYP086
MIFTS: 69

Hypothyroidism

Categories: Endocrine diseases, Immune diseases, Metabolic diseases, Neuronal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Hypothyroidism

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MalaCards integrated aliases for Hypothyroidism:

Name: Hypothyroidism 12 73 29 54 6 42 44 15 17 70
Thyroid Diseases 54 42 70
Thyroid Insufficiency 12
Dysfunction Thyroid 54
Thyroid Abnormality 6
Thyroid Dysfunction 70
Thyroid Deficiency 12
Thyroid Disease 17

Classifications:

MalaCards categories:
Global: Rare diseases Metabolic diseases
Anatomical: Endocrine diseases Neuronal diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1459
ICD9CM 34 244.9
MeSH 44 D007037
NCIt 50 C26800
SNOMED-CT 67 267465007
UMLS 70 C0020676 C0040128 C0348024
Sources

Summaries for Hypothyroidism

About this section
MedlinePlus : 42 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. It is one of your endocrine glands, which make hormones. Thyroid hormones control the rate of many activities in your body. These include how fast you burn calories and how fast your heart beats. All of these activities are your body's metabolism. Thyroid problems include Goiter - enlargement of the thyroid gland Hyperthyroidism - when your thyroid gland makes more thyroid hormones than your body needs Hypothyroidism - when your thyroid gland does not make enough thyroid hormones Thyroid cancer Thyroid nodules - lumps in the thyroid gland Thyroiditis - swelling of the thyroid To diagnose thyroid diseases, doctors use a medical history, physical exam, and thyroid tests. They sometimes also use a biopsy. Treatment depends on the problem, but may include medicines, radioiodine therapy, or thyroid surgery. Dept. of Health and Human Services Office on Women's Health

MalaCards based summary : Hypothyroidism, also known as thyroid diseases, is related to congenital hypothyroidism and hypothyroidism, congenital, nongoitrous, 2. An important gene associated with Hypothyroidism is STAT1 (Signal Transducer And Activator Of Transcription 1), and among its related pathways/superpathways are Allograft rejection and Pathways in cancer. The drugs Hyaluronic acid and Nitroprusside have been mentioned in the context of this disorder. Affiliated tissues include thyroid, pituitary and eye, and related phenotypes are behavior/neurological and growth/size/body region

Disease Ontology : 12 A thyroid gland disease which involves an underproduction of thyroid hormone.

Wikipedia : 73 Hypothyroidism (also called underactive thyroid, low thyroid or hypothyreosis) is a disorder of the... more...

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Related Diseases for Hypothyroidism

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Diseases in the Hypothyroidism family:

Congenital Hypothyroidism Central Congenital Hypothyroidism
Hypothyroidism Due to Iodide Transport Defect Rare Adult Hypothyroidism
Transient Congenital Hypothyroidism Rare Hypothyroidism
Primary Congenital Hypothyroidism Hypothyroidism Due to Deficient Transcription Factors Involved in Pituitary Development or Function
Congenital Hypothyroidism Due to Maternal Intake of Antithyroid Drugs Transient Congenital Hypothyroidism Due to Maternal Factor
Transient Congenital Hypothyroidism Due to Neonatal Factor Congenital Hypothyroidism Due to Transplacental Passage of Tsh-Binding Inhibitory Antibodies
Congenital Hypothyroidism Due to Developmental Anomaly

Diseases related to Hypothyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1668)
# Related Disease Score Top Affiliating Genes
1 congenital hypothyroidism 33.6 TSHR TSHB TRHR TRH TPO TG
2 hypothyroidism, congenital, nongoitrous, 2 33.4 TSHR TG SLC26A4 PAX8 NKX2-1
3 hypothyroidism, congenital, nongoitrous, 1 33.4 TSHR TSHB TG PAX8 IYD DUOXA2
4 hypothyroidism, central, with testicular enlargement 33.3 TSHB TRHR TRH DUOXA2
5 central congenital hypothyroidism 33.2 TSHB TRHR
6 diabetes mellitus, neonatal, with congenital hypothyroidism 33.2 TSHR SLC5A5 SLC26A4 PAX8 NKX2-1 GLIS3
7 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 33.0 SLC26A4 PAX8 NKX2-1 IYD DUOXA2
8 pendred syndrome 32.9 TPO TG SLC5A5 SLC26A4 PAX8 IYD
9 hyperthyroidism 32.9 TSHR TRHR TRH TPO TG SERPINA7
10 hashimoto thyroiditis 32.8 TSHR TPO TG SLC26A4 SERPINA7 RET
11 postsurgical hypothyroidism 32.7 TPO TG
12 myxedema 32.6 TSHR TPO TG SERPINA7
13 iodine hypothyroidism 32.6 TSHR TPO TG
14 familial thyroid dyshormonogenesis 32.5 TPO TG SLC5A5 IYD DUOXA2
15 primary congenital hypothyroidism 32.5 TSHR PAX8 NKX2-1
16 graves' disease 32.4 TSHR TPO TG SERPINA7 PAX8
17 transient congenital hypothyroidism 32.3 TSHR TPO
18 subacute thyroiditis 32.2 TSHR TPO TG SERPINA7
19 thyroid crisis 32.1 TSHR TPO TG SERPINA7
20 thyroiditis 32.0 TSHR TSHB TPO TG SERPINA7 RET
21 goiter 32.0 TSHR TRH TPO TG SLC5A5 SLC26A4
22 graves disease 1 31.9 TSHR TRH TPO TG SLC5A5 SERPINA7
23 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 31.8 TSHR TPO TG
24 athyreosis 31.8 TSHR TG SLC26A4 PAX8 NKX2-5 NKX2-1
25 thyroid carcinoma 31.7 TSHR TPO TG SLC5A5 SLC26A4 RET
26 thyroid gland disease 31.4 TSHR TSHB TRH TPO TG SLC5A5
27 adenoma 31.4 TSHR TRH TG RET
28 multinodular goiter 31.2 TSHR TPO TG SLC26A4 PAX8 NKX2-1
29 endemic goiter 31.2 TSHR TSHB TPO TG SLC26A4 SERPINA7
30 exophthalmos 31.2 TSHR TPO TG
31 differentiated thyroid carcinoma 31.1 TSHR TPO TG RET PAX8 NKX2-1
32 nodular goiter 31.0 TSHR TPO TG SLC5A5 RET
33 hypoparathyroidism 30.9 TPO RET CHD7
34 euthyroid sick syndrome 30.9 TRH TG SERPINA7
35 plummer's disease 30.9 TSHR TPO TG SERPINA7
36 mechanical strabismus 30.9 TPO TG
37 hyperthyroxinemia 30.8 TSHR TRH TPO SERPINA7
38 turner syndrome 30.7 TPO TG SERPINA7
39 papillary carcinoma 30.7 TSHR TPO TG RET PAX8 NKX2-1
40 dyshormonogenic goiter 30.6 SLC26A4 IYD DUOXA2
41 suppurative thyroiditis 30.5 TSHR TRH TPO TG SLC5A5
42 papillary thyroid microcarcinoma 30.5 TSHR TG NKX2-1
43 hypotropia 30.5 TSHR TPO
44 struma ovarii 30.5 TSHR TG RET NKX2-1
45 hypothalamic disease 30.5 TSHB TRH
46 thyroid malformation 30.4 PAX8 NKX2-5 NKX2-1
47 thyroid hormone resistance, generalized, autosomal dominant 30.4 TSHR TSHB TRH TG SERPINA7
48 toxic diffuse goiter 30.4 TSHR TPO TG SERPINA7
49 acute thyroiditis 30.4 TPO TG SERPINA7 IYD
50 nontoxic goiter 30.4 TSHR TPO TG SERPINA7

Comorbidity relations with Hypothyroidism via Phenotypic Disease Network (PDN): (show top 50) (show all 153)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Allergic Rhinitis Alzheimer Disease
Anxiety Aortic Valve Disease 1
Atypical Depressive Disorder Autonomic Nervous System Disease
Basilar Artery Insufficiency Benign Essential Hypertension
Bipolar Disorder Borderline Personality Disorder
Bronchiectasis Bronchitis
Bronchopneumonia Celiac Disease 1
Cerebral Atherosclerosis Cerebral Degeneration
Cerebrovascular Disease Chronic Kidney Disease
Chronic Pulmonary Heart Disease Communicating Hydrocephalus
Congenital Hypothyroidism Conjunctivitis
Conn's Syndrome Conversion Disorder
Cystitis Decubitus Ulcer
Deficiency Anemia Delusional Disorder
Dependent Personality Disorder Dermatomycosis
Diabetes Insipidus Diabetic Polyneuropathy
Dyshormonogenic Goiter Dyskinesia of Esophagus
Dysthymic Disorder Encephalopathy
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Esophagitis
Exophthalmos Familial Atrial Fibrillation
Female Breast Cancer Female Stress Incontinence
Femoral Vein Thrombophlebitis First-Degree Atrioventricular Block
Gastroesophageal Reflux Generalized Anxiety Disorder

Graphical network of the top 20 diseases related to Hypothyroidism:



Diseases related to Hypothyroidism
Sources

Symptoms & Phenotypes for Hypothyroidism

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MGI Mouse Phenotypes related to Hypothyroidism:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.34 CHD7 DUOXA2 GNB1 NKX2-1 PAX8 RET
2 growth/size/body region MP:0005378 10.31 CHD7 DUOXA2 GLIS3 GNB1 NKX2-1 NKX2-5
3 endocrine/exocrine gland MP:0005379 10.28 CHD7 GLIS3 NKX2-1 NKX2-5 PAX8 RET
4 homeostasis/metabolism MP:0005376 10.2 CHD7 DUOXA2 GLIS3 NKX2-1 NKX2-5 PAX8
5 cardiovascular system MP:0005385 10.18 CHD7 DUOXA2 GNB1 NKX2-1 NKX2-5 PAX8
6 digestive/alimentary MP:0005381 10.06 CHD7 NKX2-1 NKX2-5 RET SLC26A4 STAT1
7 hearing/vestibular/ear MP:0005377 9.91 CHD7 DUOXA2 PAX8 SLC26A4 SLC5A5 TPO
8 limbs/digits/tail MP:0005371 9.91 CHD7 DUOXA2 GNB1 PAX8 RET STAT1
9 nervous system MP:0003631 9.9 CHD7 GNB1 NKX2-1 NKX2-5 PAX8 RET
10 reproductive system MP:0005389 9.61 CHD7 NKX2-1 PAX8 RET SLC26A4 TG
11 skeleton MP:0005390 9.4 CHD7 DUOXA2 GNB1 NKX2-1 PAX8 SLC26A4
Sources

Drugs & Therapeutics for Hypothyroidism

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Drugs for Hypothyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 367)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
2
Nitroprusside Approved, Investigational Phase 4 15078-28-1 11963622
3
Nitric Oxide Approved Phase 4 10102-43-9 145068
4
Iron Approved Phase 4 7439-89-6 23925 29936
5
Selenium Approved, Investigational, Vet_approved Phase 4 7782-49-2
6
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
7
Salmon calcitonin Approved, Investigational Phase 4 47931-85-1 16129616
8
Levoleucovorin Approved, Investigational Phase 4 68538-85-2 149436
9
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 15589840
10
Copper Approved, Investigational Phase 4 7440-50-8 27099
11
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
12
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
13
tannic acid Approved Phase 4 1401-55-4
14
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
15
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
16
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
17
Acetaminophen Approved Phase 4 103-90-2 1983
18
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
19
Phenylpropanolamine Approved, Vet_approved, Withdrawn Phase 4 14838-15-4 26934
20
Codeine Approved, Illicit Phase 4 76-57-3 5284371
21
Iodine Approved, Investigational Phase 4 7553-56-2 807
22
Metformin Approved Phase 4 657-24-9 4091 14219
23
Leuprolide Approved, Investigational Phase 4 53714-56-0 3911 657181
24
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
25
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
26
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
27
Tyrosine Approved, Investigational, Nutraceutical Phase 4 60-18-4 6057
28
Calcitonin gene-related peptide Investigational Phase 4 83652-28-2
29
Cobalamin Experimental Phase 4 13408-78-1 6857388
30
Cadexomer iodine Experimental Phase 4 94820-09-4
31 Hormones Phase 4
32 insulin Phase 4
33 Insulin, Globin Zinc Phase 4
34 Adjuvants, Immunologic Phase 4
35 Viscosupplements Phase 4
36 Proxymetacaine Phase 4
37 Carboxymethylcellulose Sodium Phase 4
38 Trace Elements Phase 4
39 Micronutrients Phase 4
40 Vitamins Phase 4
41 Calcium, Dietary Phase 4
42 Triamcinolone diacetate Phase 4
43 triamcinolone acetonide Phase 4
44 Triamcinolone hexacetonide Phase 4
45 Katacalcin Phase 4
46 calcitonin Phase 4
47 Methylene diphosphonate Phase 4
48 Diphosphonates Phase 4
49 Technetium Tc 99m Medronate Phase 4
50 Vitamin B9 Phase 4

Interventional clinical trials:

(show top 50) (show all 883)
# Name Status NCT ID Phase Drugs
1 Thyroid Hormone Replacement for Hypothyroidism and Acute Myocardial Infarction Unknown status NCT02512978 Phase 4 Levothyroxine
2 Beneficial Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism Unknown status NCT02316743 Phase 4 Levothyroxine supplementation
3 Total Thyroidectomy With Harmonic Scalpel® Versus Standard Surgery. Open Multicentric Randomized Controlled Trial Unknown status NCT00385983 Phase 4
4 Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General anesthesia---a Randomized Control Double-Blind Clinical Trial Unknown status NCT02613806 Phase 4 Dexmeditomidine;normal saline
5 Does Sodium Nitroprusside Infusion Affect Thyroidal Function in Patients Undergoing Coronary Artery Bypass Grafting, a Prospective Randomized Clinical Trial. Unknown status NCT00636584 Phase 4 sodium nitroprusside;placebo
6 Open-Label, Multi-Center, Randomized, Active-Controlled, Phase 4 Study of rAd-p53 Gene Mono-Therapy, With Concurrent Radioactive Iodine , or Combination With Surgery in Subjects With Advanced Malignant Thyroid Tumors Unknown status NCT00902122 Phase 4 rAd-p53 gene;p53 gene therapy
7 The Use of Lu177 in the Treatment of Progressive and Unresectable Metastatic Medullary Thyroid Cancer Unknown status NCT01915485 Phase 4
8 Efficacy of Dexmedetomidine for Cough Suppression During Anesthetic Emergence in Patients Undergoing Thyroid Surgery: A Randomized, Double Blinded, Controlled Trial Unknown status NCT03312413 Phase 4 Dexmedetomidine Hydrochloride;Normal Saline;Dexmedetomidine Hydrochloride;Dexmedetomidine Hydrochloride
9 Phase IV Study of Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Unknown status NCT01738243 Phase 4 Hyaluronic Acid Gel injection;Saline injection
10 What is the Optimal Serum TSH Concentration During Thyroxine Treatment for Primary Hypothyroidism? Effects of Fine Titration of Thyroxine Dosage on Wellbeing, Quality of Life and Cognitive Function Unknown status NCT00111735 Phase 4 Thyroxine
11 Efficacy and Safety of Levothyroxine (L-T4) Replacement on Exercise Capability in Chronic Systolic Heart Failure Patients With Subclinical Hypothyroidism: A 24-week, Multi-center, Open Label, Randomized, Parallel Group Trial Unknown status NCT03096613 Phase 4 Levothyroxine
12 Randomized Crossover Trial for the Evaluation of the Possible Effects in the Intestine of Two Different Pharmaceutical Forms of L - Thyroxine in Patients With Primary Acquired Hypothyroidism Unknown status NCT02917863 Phase 4 L-Thyroxine (tablet, per os);L-Thyroxine (oral drops, solution)
13 Effects of Thyroid Hormone Treatment on Mitochondrial Function, Ectopic Fat Accumulation, Insulin Sensitivity and Brown Adipose Tissue in Type 2 Diabetes Mellitus Unknown status NCT01379170 Phase 4 Euthyrox (levothyroxine)
14 Effect of Thyroid Hormone Replacement on Fatigability in Untreated Older Adults With Subclinical Hypothyroidism Completed NCT02500342 Phase 4 Levothyroxine;Placebo
15 Impact of Thyroid Hormone Replacement on Cardiac Function: a Randomized Placebo-Controlled Trial in Older Adults With Subclinical Hypothyroidism Completed NCT02832960 Phase 4 Levothyroxine;Placebo
16 Impact of Thyroid Hormone Replacement on Progression of Atherosclerosis : a Randomized Placebo-Controlled Trial in Older Adults With Subclinical Hypothyroidism. Completed NCT02832934 Phase 4 Levothyroxine;Placebo
17 Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction: a Prospective Evaluation and Impact of Treatment Completed NCT02491008 Phase 4 Levothyroxine;Placebo
18 A Dosimetry Study of Radioiodine (131-I) Uptake Following the Administration of Thyrogen and Hypothyroid States During Thyroid Hormone Withdrawal Completed NCT00001730 Phase 4 Thyrogen
19 Thyroid Hormone Replacement for Subclinical Hypothyroidism (TRUST) - Subanalysis on Subclinical Hypothyroidism and Depression Completed NCT01853579 Phase 4 Levothyroxine;Placebo
20 Is the Routine Pressure Dressing After Thyroidectomy Necessary? A Prospective Randomized Controlled Study Completed NCT00400465 Phase 4
21 A Double-masked, Methylprednisolone-control, Efficacy and Safety Study of 99Tc-MDP for Thyroid Associated Ophthalmopathy. Completed NCT03948191 Phase 4 Methylprednisolone;99Tc-MDP(99Technetium-Methylenediphosphonate Injection)
22 Diagnostic Accuracy Study of Indocyanine Green for Parathyroid Perfusion Assessment Completed NCT03969108 Phase 4 Indocyanine Green
23 Is it Possible to Increase Quality of Life, Using Recombinant TSH Instead of Withdrawal of Thyroid Hormone Treatment, Before Iodine Uptake in Patients With Thyroid Cancer? Completed NCT00604318 Phase 4 rhTSH
24 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
25 Multicentric Randomized Controlled Study of Percutaneous Laser Ablation Versus Follow Up in Benign Thyroid Nodules. Long Term Results Completed NCT00858104 Phase 4
26 A Randomised, Controlled, Crossover Study: Treatment With Thyroxin Compared to Thyroxin + Triiodothyronin in Patients With Secondary Hypothyroidism Completed NCT00360074 Phase 4 Thyroxin, Triiodothyronine
27 Single-center, Randomized, Double-Blinded, Comparative Study of the Effectiveness of L-carnitine in Patients'Fatigue Degree Changing With Hypothyroidism Who Take Levothyroxine Completed NCT01769157 Phase 4 L-carnitine;Placebo
28 Neurocognitive and Metabolic Effects of Mild Hypothyroidism Completed NCT00565864 Phase 4 L-thyroxine (L-T4)
29 The Effect of Thyroid Hormone Therapy on Muscle Mass and Function in Older Adults With Subclinical Hypothyroidism - a Substudy of TRUST and IEMO Trials Completed NCT04354896 Phase 4 Levothyroxin;Placebo
30 Multi-modal Effects of Thyroid Hormone Replacement for Untreated Older Adults With Subclinical Hypothyroidism; a Randomised Placebo-controlled Trial Completed NCT01660126 Phase 4 Levothyroxine;Placebo
31 Assessing Quality of Life Changes Using Calcitonin in Patients With Hypothyroidism on Biochemical Replacement With Levothyroxine Completed NCT03342001 Phase 4 Calcitonin
32 Effect of T4-T3 Combination Therapy Versus T4 Monotherapy in Patients With Hypothyroidism,a Double Blind Randomized Cross-Over Study. Completed NCT00531713 Phase 4 Triiodothyronine
33 A Single-center Interventional Study to Verify Clinical Utility of the Quantitative and the Qualitative POC TSH Test Kits Compared With the Third Generation TSH Test Kit Completed NCT01921452 Phase 4
34 An Open-label Therapeutic Efficacy Study of Tirosint (Levothyroxine Sodium) Capsules in Thyroidectomized Patients Taking Proton Pump Inhibitors Completed NCT03094416 Phase 4 levothyroxine sodium capsule
35 Study of Optimal Replacement of Thyroxine in the Elderly (SORTED) SORTED 1 - a Randomised Controlled Trial (Pilot Study), SORTED 2 - Qualitative Interviews, SORTED 3 - Retrospective Cohort Completed NCT01647750 Phase 4 Levothyroxine;Levothyroxine
36 Bioequivalence of Two Levothyroxine Tablet Formulations in Healthy Indian Volunteers: A Single-dose, Randomized, Open-label, Crossover Study Completed NCT01536678 Phase 4 Levothyroxine;Levothyroxine
37 Iodine Intake & Status of Preschoolers Given Micronutrient Powder for 6 Months Completed NCT02280330 Phase 4
38 A Prospective, Multicenter Observational Study to Evaluate Thyroid Function of Pediatric Subjects From Birth to 3 Years Exposed to ISOVUE® (Iopamidol Injection) Recruiting NCT03779906 Phase 4 Isovue
39 Randomized Controlled Trial of Preoperative Steroids in Autoimmune Thyroid Disease Recruiting NCT04542278 Phase 4 Prednisone
40 Intravenous Or Topical Lidocaine And Neuromonitoring in Thyroid Surgery (IOLANT Study) Recruiting NCT04574947 Phase 4 Intravenous lidocaine;Intravenous placebo
41 Discontinuation of Levothyroxine Therapy for Patients With Subclinical Hypothyroidism: a Pilot Randomized, Double-blinded, Placebo-controlled Study Recruiting NCT04288115 Phase 4 Levothyroxine
42 Use of Liquid Stable Levothyroxine in Trisomy 21 Pediatric Patients Recruiting NCT04747275 Phase 4 Oral tablet levothyroxine (L-T4);Liquid stable levothyroxine (L-T4) Tirosint-SOL
43 The Beneficial Effect of L-Thyroxine Long -Term Replacement on Lipid Profiles and Atherosclerosis in Subclinical Hypothyroidism: A Prospective Study Active, not recruiting NCT01831869 Phase 4 L-thyroxine
44 Effects of Long-term L-thyroxine Replacement on Serum Lipid and Atherosclerosis in Patients With Hypothyroidism Active, not recruiting NCT01848171 Phase 4 L-thyroxine
45 Prospective Single Arm Post Marketing Phase IV Study to Assess the Safety and Efficacy of Lenvatinib in Subjects With Locally Recurrent or Metastatic, Progressive, Radioiodine Refractory Differentiated Thyroid Cancer Active, not recruiting NCT03573960 Phase 4 Lenvatinib
46 A Randomized, Double-blind Study To Evaluate the Efficacy and Safety of Cabozantinib (XL184) at 60 mg/Day Compared to a 140 mg/Day in Progressive, Metastatic Medullary Thyroid Cancer Patients Active, not recruiting NCT01896479 Phase 4 Cabozantinib (XL184) 140 mg;Cabozantinib (XL184) 60 mg;Placebo tablet;Placebo capsule
47 An International, Randomised, Double-Blind, Two-Arm Study To Evaluate The Safety And Efficacy Of Vandetanib 150 And 300mg/Day In Patients With Unresectable Locally Advanced Or Metastatic Medullary Thyroid Carcinoma With Progressive Or Symptomatic Disease Active, not recruiting NCT01496313 Phase 4 300mg vandetanib;150mg vandetanib
48 Minimizing Narcotic Analgesics After Thyroid or Parathyroid Surgery Active, not recruiting NCT03469310 Phase 4 Acetaminophen 500Mg Cap;Tylenol #3 Oral Tablet;Tramadol
49 Distribution of Selenium in Patients With Differentiated Thyroid Carcinoma and Effect of Selenium Supplement on Prognosis of Patients With Differentiated Thyroid Carcinoma. Not yet recruiting NCT04683575 Phase 4 Selenium Yeast;Placebo
50 Efficacy of Metformin Versus Sitagliptin on Benign Thyroid Nodules Size in Type 2 Diabetes: a 2-years Prospective Multicentric Study Not yet recruiting NCT04298684 Phase 4 METFORMIN;Sitagliptin

Search NIH Clinical Center for Hypothyroidism

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Kelp preparation

Cochrane evidence based reviews: hypothyroidism

Sources

Genetic Tests for Hypothyroidism

About this section

Genetic tests related to Hypothyroidism:

# Genetic test Affiliating Genes
1 Hypothyroidism 29
Sources

Anatomical Context for Hypothyroidism

About this section

MalaCards organs/tissues related to Hypothyroidism:

40
Thyroid, Pituitary, Eye, Lymph Node, Endothelial, Cortex, Ovary
Sources

Publications for Hypothyroidism

About this section

Articles related to Hypothyroidism:

(show top 50) (show all 34303)
# Title Authors PMID Year
1
Efficacy and safety of thyroxine therapy on patients with heart failure and subclinical hypothyroidism: A protocol for systematic review and meta-analysis. 61 42
33545971 2021
2
Whole-genome sequencing of patients with rare diseases in a national health system. 6
32581362 2020
3
Adherence to levothyroxine prescription in patients with hypothyroidism. 42 61
33480371 2020
4
Treatment of hypothyroidism in special situations. 61 42
33481737 2020
5
Best Achievements in Clinical Thyroidology in 2020. 42
33677923 2021
6
Surgical management and outcome of patients with thyroid disease during the COVID-19 pandemic. 42
33640933 2021
7
Thyroid Function Abnormalities in COVID-19 Patients. 42
33679608 2020
8
Runx2 deficiency in mice causes decreased thyroglobulin expression and hypothyroidism. 54 61
20375239 2010
9
Genetics and phenomics of hypothyroidism and goiter due to thyroglobulin mutations. 61 54
20093166 2010
10
Genetics and phenomics of hypothyroidism and goiter due to NIS mutations. 54 61
20153805 2010
11
Genetics and phenomics of hypothyroidism and goiter due to TPO mutations. 54 61
20153806 2010
12
Genetics and phenomics of hypothyroidism and thyroid dys- and agenesis due to PAX8 and TTF1 mutations. 54 61
20302910 2010
13
Congenital hypothyroidism in a kitten resulting in decreased IGF-I concentration and abnormal liver function tests. 61 54
20223692 2010
14
Dual oxidase, hydrogen peroxide and thyroid diseases. 61 54
20407074 2010
15
Four patients with hypothyroid Graves' disease. 61 54
20421660 2010
16
Turner syndrome and schizophrenia: a further hint for the role of the X-chromosome in the pathogenesis of schizophrenic disorders. 61 54
20218787 2010
17
Biallelic p.R2223H mutation in the thyroglobulin gene causes thyroglobulin retention and severe hypothyroidism with subsequent development of thyroid carcinoma. 54 61
20089614 2010
18
Molecular analysis of congenital goitres with hypothyroidism caused by defective thyroglobulin synthesis. Identification of a novel c.7006C>T [p.R2317X] mutation and expression of minigenes containing nonsense mutations in exon 7. 54 61
19438905 2010
19
Broad clinical involvement in a family affected by the fragile X premutation. 61 54
19996900 2009
20
Diagnosis and discrimination of autoimmune Graves' disease and Hashimoto's disease using thyroid-stimulating hormone receptor-containing recombinant proteoliposomes. 61 54
19914592 2009
21
Environmental pollutants and the thyroid. 54 61
19942155 2009
22
GH replacement in adults: interactions with other pituitary hormone deficiencies and replacement therapies. 61 54
19684055 2009
23
Panhypopituitarism due to metastases to the hypothalamus and the pituitary resulting from primary breast cancer: a case report and review of the literature. 61 54
19933072 2009
24
[Clinical significance of apolipoprotein B-48 (apoB-48) in patients with thyroid disease]. 54 61
20030174 2009
25
Thyrotropin-stimulating hormone receptor gene analysis in pediatric patients with non-autoimmune subclinical hypothyroidism. 54 61
19820021 2009
26
Congenital leptin deficiency and thyroid function. 61 54
19889232 2009
27
More hypothyroidism and less hyperthyroidism with sufficient iodine nutrition compared to mild iodine deficiency--a comparative population-based study of older people. 54 61
19762181 2009
28
Subclinical hypothyroidism and autoimmune thyroiditis in pregnancy--a study in south Indian subjects. 61 54
20329425 2009
29
Radioiodine ablation: when and how. 61 54
19910900 2009
30
Final diagnosis in children with subclinical hypothyroidism and mutation analysis of the thyroid peroxidase gene (TPO). 54 61
19960894 2009
31
The p.A2215D thyroglobulin gene mutation leads to deficient synthesis and secretion of the mutated protein and congenital hypothyroidism with wide phenotype variation. 54 61
19509106 2009
32
Subclinical hypothyroidism in children and adolescents: a wide range of clinical, biochemical, and genetic factors involved. 54 61
19417038 2009
33
Ovarian hyper-stimulation syndrome after spontaneous conception. 61 54
19499413 2009
34
[Sarcoidosis associated with hypothyroidism due to thyrotropin-receptor blocking antibodies]. 61 54
18930567 2009
35
Persistent hyperprolactinemia following mammoplasty: a rare association. 54 61
19634649 2009
36
Effects of thyroxine replacement on serum creatinine and cystatin C in patients with primary and central hypothyroidism. 61 54
19529992 2009
37
Type 2 iodothyronine deiodinase in skeletal muscle: effects of hypothyroidism and fasting. 54 61
19293265 2009
38
TSH receptor - autoantibody interactions. 61 54
19530271 2009
39
Growth hormone/insulin-like growth factor axis in patients with subclinical thyroid dysfunction. 61 54
19111490 2009
40
[Sodium-iodine symporter in thyroid, normal and cancer tissues and its relation to nuclear medicine and to gene cloning treatment]. 61 54
19675882 2009
41
Serum leptin in overt and subclinical hypothyroidism: effect of levothyroxine treatment and relationship to menopausal status and body composition. 61 54
19415994 2009
42
Persistence of goitre in children post-salt iodization in Islamic Republic of Iran: autoimmune status. 61 54
19731774 2009
43
Mainly the younger hypothyroid patients are referred to hospital--evidence for referral bias. 54 61
18945587 2009
44
Evolution of sonographic appearance of the thyroid gland in children with Hashimoto's thyroiditis. 61 54
19554808 2009
45
Thyroid function and changes in ultrasound morphology during antiviral therapy with pegylated interferon and ribavirin in patients with chronic hepatitis C. 54 61
19175874 2009
46
Influence of iodide excess and interferon-gamma on human primary thyroid cell proliferation, thyroglobulin secretion, and intracellular adhesion molecule-1 and human leukocyte antigen-DR expression. 61 54
19265500 2009
47
Increased thrombin-activatable fibrinolysis inhibitor and decreased tissue factor pathway inhibitor in patients with hypothyroidism. 54 61
18958631 2009
48
Cardiac troponin T is not increased in patients with hypothyroidism. 54 61
19356187 2009
49
An inactivating mutation within the first extracellular loop of the thyrotropin receptor impedes normal posttranslational maturation of the extracellular domain. 61 54
18927215 2009
50
Non-functioning pituitary adenomas: clinical feature, laboratorial and imaging assessment, therapeutic management and outcome. 54 61
19347183 2009
Sources

Variations for Hypothyroidism

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ClinVar genetic disease variations for Hypothyroidism:

6 (show all 16)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 CHD7 NM_017780.4(CHD7):c.6892C>T (p.Gln2298Ter) SNV Pathogenic 374090 rs1057518891 GRCh37: 8:61767038-61767038
GRCh38: 8:60854479-60854479
2 GNB1 NM_002074.5(GNB1):c.239T>C (p.Ile80Thr) SNV Pathogenic 208722 rs752746786 GRCh37: 1:1737942-1737942
GRCh38: 1:1806503-1806503
3 RET NM_020975.6(RET):c.2753T>C (p.Met918Thr) SNV Pathogenic 13919 rs74799832 GRCh37: 10:43617416-43617416
GRCh38: 10:43121968-43121968
4 STAT1 NM_007315.3(STAT1):c.1154C>T (p.Thr385Met) SNV Pathogenic 144006 rs587777630 GRCh37: 2:191851647-191851647
GRCh38: 2:190986921-190986921
5 STAT1 NM_007315.3(STAT1):c.1154C>T (p.Thr385Met) SNV Pathogenic 144006 rs587777630 GRCh37: 2:191851647-191851647
GRCh38: 2:190986921-190986921
6 COL7A1 NM_000094.3(COL7A1):c.1442G>A (p.Arg481His) SNV Likely pathogenic 373954 rs147040026 GRCh37: 3:48629171-48629171
GRCh38: 3:48591738-48591738
7 POGZ NM_015100.4(POGZ):c.402_409dup (p.His137fs) Duplication Likely pathogenic 373957 rs1057518799 GRCh37: 1:151403191-151403192
GRCh38: 1:151430715-151430716
8 ADNP NM_001282531.3(ADNP):c.2188C>T (p.Arg730Ter) SNV Likely pathogenic 279598 rs886041116 GRCh37: 20:49509063-49509063
GRCh38: 20:50892526-50892526
9 TG NM_003235.5(TG):c.5804del (p.Asn1935fs) Deletion Likely pathogenic 689597 rs1587618417 GRCh37: 8:133980155-133980155
GRCh38: 8:132967910-132967910
10 SLC33A1 NM_004733.4(SLC33A1):c.963+1G>A SNV Likely pathogenic 812763 rs1266904735 GRCh37: 3:155560220-155560220
GRCh38: 3:155842431-155842431
11 TSHR NM_000369.5(TSHR):c.202C>T (p.Pro68Ser) SNV Uncertain significance 437071 rs142063461 GRCh37: 14:81528523-81528523
GRCh38: 14:81062179-81062179
12 SCNN1A NM_001038.6(SCNN1A):c.1427G>A (p.Arg476Gln) SNV Uncertain significance 598965 rs72657556 GRCh37: 12:6458505-6458505
GRCh38: 12:6349339-6349339
13 CR1 NM_000651.6(CR1):c.6283C>A (p.His2095Asn) SNV Uncertain significance 812547 rs1571590802 GRCh37: 1:207783021-207783021
GRCh38: 1:207609676-207609676
14 PAX8 NM_003466.4(PAX8):c.1011del (p.Val339fs) Deletion Uncertain significance 598954 rs1558700308 GRCh37: 2:113993047-113993047
GRCh38: 2:113235470-113235470
15 HUWE1 NM_031407.7(HUWE1):c.6485G>C (p.Arg2162Pro) SNV Uncertain significance 523539 rs1556948950 GRCh37: X:53596615-53596615
GRCh38: X:53569655-53569655
16 overlap with 3 genes GRCh37/hg19 6q25.3(chr6:156772218-157870875)x3 copy number gain Uncertain significance 523303 GRCh37: 6:156772218-157870875
GRCh38:
Sources

Expression for Hypothyroidism

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Search GEO for disease gene expression data for Hypothyroidism.
Sources

Pathways for Hypothyroidism

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Pathways related to Hypothyroidism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Allograft rejection 1 36
Show member pathways
 12.54 TSHR TSHB TPO TG STAT1 IFNA1
2
Pathways in cancer 36
12.49 STAT1 RET PAX8 IFNA1 GNB1
3
Aldosterone synthesis and secretion 36
Show member pathways
 12.42 TSHR TSHB TPO TG SLC5A5 SLC26A4
4
Human Thyroid Stimulating Hormone (TSH) signaling pathway 1
11.39 TSHR TSHB STAT1 PAX8 GNB1
5
Amine-derived hormones 65
Show member pathways
 11.16 TSHB TPO SLC5A5 IYD
6
Hormone ligand-binding receptors 65
10.52 TSHR TSHB
7
Thyroxine (Thyroid Hormone) Production 1
9.8 TSHR TRH TPO TG SLC5A5
Sources

GO Terms for Hypothyroidism

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Biological processes related to Hypothyroidism according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.1 TSHR TRHR TRH TG STAT1 RET
2 retina development in camera-type eye GO:0060041 9.58 RET GNB1 CHD7
3 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.52 RET IFNA1
4 innervation GO:0060384 9.51 RET CHD7
5 hormone-mediated signaling pathway GO:0009755 9.5 TSHR TSHB TRH
6 adult heart development GO:0007512 9.48 NKX2-5 CHD7
7 hormone biosynthetic process GO:0042446 9.46 TPO TG
8 thyroid hormone metabolic process GO:0042403 9.43 TG IYD
9 cellular response to gonadotropin stimulus GO:0071371 9.37 SLC5A5 PAX8
10 iodide transport GO:0015705 9.33 TG SLC5A5 SLC26A4
11 thyroid-stimulating hormone signaling pathway GO:0038194 9.26 TSHR PAX8
12 thyroid gland development GO:0030878 9.26 TG PAX8 NKX2-5 NKX2-1
13 thyroid hormone generation GO:0006590 8.92 TPO TG SLC5A5 IYD

Molecular functions related to Hypothyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.43 TSHB TRH TG
2 iodide transmembrane transporter activity GO:0015111 9.16 SLC5A5 SLC26A4
3 thyroid-stimulating hormone receptor activity GO:0004996 8.96 TSHR PAX8
4 iodide peroxidase activity GO:0004447 8.62 TPO IYD
Sources

Sources for Hypothyroidism

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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