MCID: HYP086
MIFTS: 66

Hypothyroidism

Categories: Endocrine diseases, Immune diseases, Metabolic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Hypothyroidism

Summaries for Hypothyroidism

MedlinePlus : 44 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. It is one of your endocrine glands, which make hormones. Thyroid hormones control the rate of many activities in your body. These include how fast you burn calories and how fast your heart beats. All of these activities are your body's metabolism. Thyroid problems include Goiter - enlargement of the thyroid gland Hyperthyroidism - when your thyroid gland makes more thyroid hormones than your body needs Hypothyroidism - when your thyroid gland does not make enough thyroid hormones Thyroid cancer Thyroid nodules - lumps in the thyroid gland Thyroiditis - swelling of the thyroid To diagnose thyroid diseases, doctors use a medical history, physical exam, and thyroid tests. They sometimes also use a biopsy. Treatment depends on the problem, but may include medicines, radioiodine therapy, or thyroid surgery. Dept. of Health and Human Services Office on Women's Health

MalaCards based summary : Hypothyroidism, also known as thyroid diseases, is related to hypothyroidism, congenital, nongoitrous, 2 and hypothyroidism, central, and testicular enlargement. An important gene associated with Hypothyroidism is RET (Ret Proto-Oncogene), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Allograft rejection. The drugs Selenium and Iodine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and breast, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Disease Ontology : 12 A thyroid gland disease which involves an underproduction of thyroid hormone.

Wikipedia : 77 Hypothyroidism, also called underactive thyroid or low thyroid, is a disorder of the endocrine system in... more...

Related Diseases for Hypothyroidism

Diseases in the Hypothyroidism family:

Congenital Hypothyroidism Central Congenital Hypothyroidism
Hypothyroidism Due to Iodide Transport Defect Hypothyroidism Due to Deficient Transcription Factors Involved in Pituitary Development or Function
Congenital Hypothyroidism Due to Maternal Intake of Antithyroid Drugs Congenital Hypothyroidism Due to Transplacental Passage of Tsh-Binding Inhibitory Antibodies

Diseases related to Hypothyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 957)
# Related Disease Score Top Affiliating Genes
1 hypothyroidism, congenital, nongoitrous, 2 34.7 NKX2-1 PAX8 SERPINA7 SLC26A4 TG TSHR
2 hypothyroidism, central, and testicular enlargement 34.7 DUOX2 DUOXA2 TRH TSHB
3 hypothyroidism, congenital, nongoitrous, 4 34.5 SERPINA7 TG TPO TRH TSHB
4 congenital hypothyroidism 34.4 DUOX2 DUOXA2 GLIS3 IYD NKX2-1 NKX2-5
5 postsurgical hypothyroidism 34.3 TG TRH TSHR
6 pendred syndrome 33.6 DUOX2 PAX8 SLC26A4 TG TPO
7 myxedema 33.4 TG TPO TSHR
8 hashimoto thyroiditis 33.4 RET SLC26A4 TG TPO TSHB TSHR
9 hyperthyroidism 33.0 SERPINA7 TG TPO TRH TSHR
10 graves' disease 32.7 SERPINA7 TG TPO TSHR
11 subacute thyroiditis 32.7 SERPINA7 TG TPO TSHR
12 thyroid crisis 32.3 TG SERPINA7
13 thyroid gland disease 31.9 DUOXA2 NKX2-1 PAX8 RET SERPINA7 SLC26A4
14 familial thyroid dyshormonogenesis 31.8 DUOX2 DUOXA2 IYD SLC5A5 TG TPO
15 thyroid ectopia 31.8 NKX2-5 PAX8
16 athyreosis 31.7 NKX2-1 NKX2-5 PAX8 SLC26A4 TG TSHR
17 graves disease 1 31.4 SERPINA7 TG TPO TRH TSHR
18 thyroiditis 31.4 RET SERPINA7 TG TPO TRH TSHB
19 goiter 31.2 DUOXA2 IYD NKX2-1 PAX8 SERPINA7 SLC26A4
20 thyroid cancer 30.8 NKX2-1 PAX8 RET SLC26A4 SLC5A5 TG
21 differentiated thyroid carcinoma 30.6 NKX2-1 PAX8 RET TG TPO TSHR
22 endemic goiter 30.6 SERPINA7 TG TPO TSHB TSHR
23 thyroid carcinoma, familial medullary 30.5 NKX2-1 RET TG
24 thyroid hormone resistance, generalized, autosomal dominant 30.5 SERPINA7 TG TRH
25 hyperthyroxinemia 30.4 SERPINA7 TPO TRH TSHR
26 neonatal thyrotoxicosis 30.3 PAX8 TSHR
27 plummer's disease 30.3 TPO TG
28 nodular goiter 30.3 RET SLC5A5 TG TPO TSHR
29 struma ovarii 30.3 NKX2-1 RET TG TSHR
30 papillary thyroid microcarcinoma 30.3 NKX2-1 TG TSHR
31 multinodular goiter 30.2 NKX2-1 PAX8 SLC26A4 TG TPO TSHR
32 papillary carcinoma 30.2 NKX2-1 PAX8 RET TG TPO TSHR
33 goiter, multinodular 1, with or without sertoli-leydig cell tumors 30.0 TG TPO
34 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.0 TG TPO TSHR
35 toxic diffuse goiter 30.0 SERPINA7 TG TPO TRH TSHR
36 follicular adenoma 29.8 NKX2-1 PAX8 RET SLC26A4 TG TPO
37 pernicious anemia 29.8 TPO TG
38 hypothyroidism, congenital, nongoitrous, 1 12.7
39 choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction 12.7
40 diabetes mellitus, neonatal, with congenital hypothyroidism 12.5
41 central congenital hypothyroidism 12.5
42 hypothyroidism, congenital, nongoitrous, 5 12.5
43 hypothyroidism, congenital, nongoitrous, 6 12.5
44 hypothyroidism, congenital, nongoitrous, 3 12.4
45 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 12.4
46 ectodermal dysplasia, hypohidrotic, with hypothyroidism and ciliary dyskinesia 12.3
47 muscular pseudohypertrophy-hypothyroidism syndrome 12.2
48 iodine hypothyroidism 12.2
49 autoimmune thyroid disease 1 12.1
50 autoimmune thyroid disease 2 12.1

Comorbidity relations with Hypothyroidism via Phenotypic Disease Network (PDN): (show top 50) (show all 155)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Allergic Rhinitis Alzheimer Disease
Anxiety Aortic Valve Disease 1
Atypical Depressive Disorder Autonomic Nervous System Disease
Basilar Artery Insufficiency Benign Essential Hypertension
Bipolar Disorder Borderline Personality Disorder
Bronchiectasis Bronchitis
Bronchopneumonia Celiac Disease 1
Cerebral Atherosclerosis Cerebral Degeneration
Cerebrovascular Disease Chronic Kidney Failure
Chronic Myocardial Ischemia Chronic Pulmonary Heart Disease
Communicating Hydrocephalus Conjunctivitis
Conn's Syndrome Conversion Disorder
Cystitis Decubitus Ulcer
Deficiency Anemia Delusional Disorder
Dependent Personality Disorder Dermatomycosis
Diabetes Insipidus Diabetic Polyneuropathy
Dyshormonogenic Goiter Dyskinesia of Esophagus
Dysthymic Disorder Encephalopathy
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Esophagitis
Exophthalmos Familial Atrial Fibrillation
Female Breast Cancer Female Stress Incontinence
Femoral Vein Thrombophlebitis First-Degree Atrioventricular Block
Gastroesophageal Reflux Generalized Anxiety Disorder

Graphical network of the top 20 diseases related to Hypothyroidism:



Diseases related to Hypothyroidism

Symptoms & Phenotypes for Hypothyroidism

MGI Mouse Phenotypes related to Hypothyroidism:

47 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.3 CHD7 DUOX2 GLIS3 NKX2-1 NKX2-5 PAX8
2 growth/size/body region MP:0005378 10.25 CHD7 DUOX2 GLIS3 NKX2-1 NKX2-5 PAX8
3 homeostasis/metabolism MP:0005376 10.21 CHD7 DUOX2 GLIS3 NKX2-1 NKX2-5 PAX8
4 cellular MP:0005384 10.19 CHD7 GLIS3 GNB1 NKX2-1 NKX2-5 PAX8
5 digestive/alimentary MP:0005381 10.02 CHD7 NKX2-1 NKX2-5 RET SLC26A4 STAT1
6 mortality/aging MP:0010768 10 ADNP CHD7 GLIS3 GNB1 NKX2-1 NKX2-5
7 nervous system MP:0003631 9.97 ADNP CHD7 DUOX2 GNB1 NKX2-1 NKX2-5
8 limbs/digits/tail MP:0005371 9.92 CHD7 DUOXA2 PAX8 RET STAT1 TG
9 hearing/vestibular/ear MP:0005377 9.88 CHD7 DUOX2 PAX8 SLC26A4 TPO TSHR
10 reproductive system MP:0005389 9.56 CHD7 DUOX2 NKX2-1 PAX8 RET SLC26A4
11 skeleton MP:0005390 9.32 CHD7 DUOX2 DUOXA2 NKX2-1 PAX8 SLC26A4

Drugs & Therapeutics for Hypothyroidism

Drugs for Hypothyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 900)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Selenium Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 7782-49-2
2
Iodine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 7553-56-2 807
3
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 5311068 68602
4
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
5
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
6
Methimazole Approved Phase 4,Phase 2,Phase 1,Not Applicable 60-56-0 1349907
7
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
8
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
9
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
10
Nitric Oxide Approved Phase 4,Not Applicable 10102-43-9 145068
11
Nitroprusside Approved, Investigational Phase 4 15078-28-1 11963622
12
Propylthiouracil Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 51-52-5 657298
13
Betamethasone Approved, Vet_approved Phase 4,Phase 3 378-44-9 9782
14
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
15
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 53-03-2 5865
16
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
17
Amiodarone Approved, Investigational Phase 4,Phase 3,Not Applicable 1951-25-3 2157
18
tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1401-55-4
19
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1994-09-7, 94-09-7 2337
20
Somatostatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 38916-34-6, 51110-01-1 53481605
21
Pasireotide Approved Phase 4,Phase 3,Phase 2 396091-73-9 9941444
22
Octreotide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 83150-76-9 6400441 383414
23
lanreotide Approved Phase 4,Phase 1,Phase 2 108736-35-2
24
Sodium Citrate Approved, Investigational Phase 4,Phase 2,Phase 1,Early Phase 1 68-04-2
25
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 302-25-0
26
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-24-8 5755
27
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 2921-57-5
28
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 83-43-2 6741
29
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 143 6006
30
Iron Approved, Experimental Phase 4,Phase 2,Phase 1,Not Applicable 7439-89-6, 15438-31-0 27284 23925
31
Hydroxocobalamin Approved Phase 4,Phase 2,Not Applicable 13422-51-0 15589840 11953898
32
Bexarotene Approved, Investigational Phase 4,Phase 3,Phase 1,Early Phase 1 153559-49-0 82146
33
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 2,Phase 3 198153-51-4 5360545
34
Ribavirin Approved Phase 4,Phase 2,Phase 3 36791-04-5 37542
35
Triamcinolone Approved, Vet_approved Phase 4,Not Applicable 124-94-7 31307
36
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-28-2 5757
37
Polyestradiol phosphate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 28014-46-2
38
Testosterone Approved, Experimental, Investigational Phase 4,Phase 1,Not Applicable,Early Phase 1 58-22-0, 481-30-1 10204 6013
39
Dinoprost Approved, Investigational Phase 4,Not Applicable 551-11-1 5283078
40
Dinoprost tromethamine Approved, Vet_approved Phase 4,Not Applicable 38562-01-5 5282415
41
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 525-66-6 4946
42
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1177-87-3
43
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
44
Peginterferon alfa-2b Approved Phase 4,Phase 2,Phase 3 215647-85-1, 99210-65-8
45
Sunitinib Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 557795-19-4, 341031-54-7 5329102
46
Glucagon Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 16941-32-5
47
Liraglutide Approved Phase 4,Phase 3,Phase 2,Not Applicable 204656-20-2 44147092
48
Parathyroid hormone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9002-64-6
49
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Not Applicable 103-90-2 1983
50
Acetylcholine Approved, Investigational Phase 4,Phase 2,Phase 3 51-84-3 187

Interventional clinical trials:

(show top 50) (show all 2049)
# Name Status NCT ID Phase Drugs
1 Randomized Crossover Trial for the Evaluation of the Possible Effects in the Intestine of Two Different Pharmaceutical Forms of L - Thyroxine in Patients With Primary Acquired Hypothyroidism Unknown status NCT02917863 Phase 4 L-Thyroxine (tablet, per os);L-Thyroxine (oral drops, solution)
2 Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism Unknown status NCT02316743 Phase 4 Levothyroxine supplementation
3 Thyroxine Titration Study Unknown status NCT00111735 Phase 4 Thyroxine
4 Thyroid Study Type 2 Diabetes Mellitus (T2DM) Unknown status NCT01379170 Phase 4 Euthyrox (levothyroxine)
5 Selenium Supplementation in Youths With Autoimmune Thyroiditis Unknown status NCT02644707 Phase 4
6 rAd-p53 Gene Therapy for Advanced Malignant Thyroid Tumors Unknown status NCT00902122 Phase 4 rAd-p53 gene;p53 gene therapy
7 Radiolabeled Molecules for Medullary Thyroid Cancer Unknown status NCT01915485 Phase 4
8 Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General Anesthesia Unknown status NCT02613806 Phase 4 Dexmeditomidine;normal saline
9 Etoricoxib for Postoperative Pain After Thyroid Surgery Unknown status NCT00935116 Phase 4 etoricoxib
10 Cardiopulmonary Capacity in Elderly With Different Ranges of Serum Thyroid Stimulating Hormone Unknown status NCT01849861 Phase 4 Methimazole
11 Effect of Propofol on Remifentanil-induced Postoperative Hyperalgesia in Patients Undergoing Thyroid Surgery Unknown status NCT01189721 Phase 4 propofol, sevoflurane
12 Clinical Study Investigating the Effect of Sodium Nitroprusside Infusion on Thyroidal Function Unknown status NCT00636584 Phase 4 sodium nitroprusside;placebo
13 The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy Unknown status NCT01056419 Phase 4 Propylthiouracil
14 Total Thyroidectomy With Harmonic Scalpel® Unknown status NCT00385983 Phase 4
15 The Role of Levothyroxine on Goiter With Atypia of Undetermined Significance Unknown status NCT02329379 Phase 4 Levothyroxine
16 Steroids in the Postoperative Transient Hypoparathyroidism Total Thyroidectomy Unknown status NCT02652884 Phase 4 phosphate and betamethasone acetate, 2 mL.;saline 0.9% NaCl
17 Trial Evaluating Use of Arista in Total Thyroidectomy Unknown status NCT02568085 Phase 4
18 Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions Unknown status NCT02190994 Phase 4 Hydrocortisone;Prednisone
19 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
20 Cardiac Resynchronization in Atrial Fibrillation Trial - a Pilot Study Unknown status NCT01850277 Phase 4 Amiodarone;Pharmacotherapy to slow and control ventricular rate
21 Pasireotide LAR and Pegvisomant Study in Acromegaly Unknown status NCT02668172 Phase 4 Pasireotide LAR 60 mg;Pegvisomant
22 Sildenafil Activates Browning of White Adipose and Improves Insulin Sensitivity Unknown status NCT02524184 Phase 4 sildenafil;placebo
23 AMIOdarone vs. Catheter Ablation for Prevention of Recurrent Symptomatic Atrial Fibrillation Unknown status NCT02341105 Phase 4 Amiodarone
24 Effect of Erythropoietin in Refractory Autoimmune Encephalitis Patients Unknown status NCT03004209 Phase 4 Erythropoietin
25 A Prospective, Randomized Trial of Intravenous Pulse Versus Sequential Steroid Therapy for Patients With Graves' Orbitopathy Unknown status NCT01969019 Phase 4 methylprednisolone, prednisone
26 Effect of Higher Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy Unknown status NCT01761149 Phase 4 Remifentanil
27 Clinical Trial to Evaluate the Efficacy of FITOGYN Versus Placebo on the Vasomotor Symptomatology Associated With Menopause Unknown status NCT01116310 Phase 4 Soy isoflavones (Glycine max L) and red clover extract (Trifolium pretense L);Placebo
28 Thyroid Hormone Replacement for Subclinical Hypothyroidism Completed NCT01660126 Phase 4 Levothyroxine;Placebo
29 Growth Hormone and GnRH Agonist in Adolescents With Acquired Hypothyroidism Completed NCT00206375 Phase 4 Growth hormone;Growth hormone treatment and puberty
30 Neurocognitive and Metabolic Effects of Mild Hypothyroidism Completed NCT00565864 Phase 4 L-thyroxine (L-T4)
31 Effects of L-carnitine on Hypothyroidism Completed NCT01769157 Phase 4 L-carnitine;Placebo
32 Effect of T4-T3 Combination Therapy Versus T4 Monotherapy in Patients With Hypothyroidism Completed NCT00531713 Phase 4 Triiodothyronine
33 Phase 4 Study in Secondary Hypothyroidism: Body Weight Adapted Thyroxin Treatment and Triiodothyronine Supplementation Completed NCT00360074 Phase 4 Thyroxin, Triiodothyronine
34 Effect of Thyroid Hormone Replacement on Fatigability in Untreated Older Adults With Subclinical Hypothyroidism Completed NCT02500342 Phase 4 Levothyroxine;Placebo
35 Study of Radioiodine (131-I) Uptake Following Administration of Thyrogen and Hypothyroid States During Thyroid Hormone Withdrawal. Completed NCT00001730 Phase 4 Thyrogen
36 The TRUST Study - Depression Substudy Completed NCT01853579 Phase 4 Levothyroxine;Placebo
37 Study of Optimal Replacement of Thyroxine in the Elderly Completed NCT01647750 Phase 4 Levothyroxine;Levothyroxine
38 Bioequivalence of Two Levothyroxine Tablet Formulations in Healthy Indian Volunteers Completed NCT01536678 Phase 4 Levothyroxine;Levothyroxine
39 Study to Verify Clinical Utility of Point-of-Care (POC) Thyroid Stimulating Hormone (TSH) Test Kits as Compared to Third Generation TSH Test Kit Completed NCT01921452 Phase 4
40 The TRUST Trial - CardioVascular Imaging ECHO Completed NCT02832960 Phase 4 Levothyroxine;Placebo
41 The TRUST Study - CardioVascular Imaging IMT Completed NCT02832934 Phase 4 Levothyroxine;Placebo
42 Iodine Status of Preschoolers Given Micronutrient Powder for 6 Months Completed NCT02280330 Phase 4
43 Carbohydrate Metabolism Disorder Frequency in Hypertriglyceridemia Induced by Bexarotene of Cutaneous T Cell Lymphoma Completed NCT01569724 Phase 4
44 Short-term Prednisone to Treat STA Study(SPTSS) Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
45 Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction Completed NCT02491008 Phase 4 Levothyroxine;Placebo
46 Safety and Efficacy of Oral Mega Pulse Methylprednisolone in Severe Therapy Resistant Alopecia Areata Completed NCT01167946 Phase 4 methylprednisolone sodium succinate;methylprednisolone sodium succinate;methylprednisolone sodium succinate
47 Long-Term Growth and Skeletal Effects of Early Growth Hormone Treatment in Turner Syndrome Completed NCT00266656 Phase 4 Humatrope
48 A Triple Combination Therapy Study of Boceprevir, Pegasys and Copegus in Previously Untreated Patients With Genotype 1 Chronic Hepatitis C Completed NCT01591460 Phase 4 boceprevir;peginterferon alfa-2a [Pegasys];peginterferon alfa-2a [Pegasys];ribavirin (Copegus];ribavirin (Copegus]
49 Percutaneous Laser Ablation in Benign Thyroid Nodules.Long Term Results Completed NCT00858104 Phase 4
50 Quality of Life, Recombinant TSH (Thyrogen) and Thyroid Cancer Completed NCT00604318 Phase 4 rhTSH

Search NIH Clinical Center for Hypothyroidism

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: hypothyroidism

Genetic Tests for Hypothyroidism

Genetic tests related to Hypothyroidism:

# Genetic test Affiliating Genes
1 Hypothyroidism 30

Anatomical Context for Hypothyroidism

MalaCards organs/tissues related to Hypothyroidism:

42
Thyroid, Heart, Breast, Testes, Pituitary, Liver, Brain

Publications for Hypothyroidism

Articles related to Hypothyroidism:

(show top 50) (show all 6755)
# Title Authors Year
1
Single-center analysis of patients with frontal fibrosing alopecia: evidence for hypothyroidism and a good quality of life. ( 30378444 )
2019
2
Hypothyroidism and the risk of breast cancer recurrence and all-cause mortality - a Danish population-based study. ( 30902106 )
2019
3
Molecular Insights Into the Relationship Between Autoimmune Thyroid Diseases and Breast Cancer: A Critical Perspective on Autoimmunity and ER Stress. ( 30881358 )
2019
4
Iodine-induced hypothyroidism in a girl with anorexia nervosa. ( 31090969 )
2019
5
Generation and characterization of monoclonal antibodies against thyroid-stimulating hormone for newborn screening of congenital hypothyroidism. ( 31043143 )
2019
6
DUOX2/DUOXA2 mutations frequently cause congenital hypothyroidism which evades detection on UK newborn screening. ( 31044655 )
2019
7
Gene Variants in NKX2-1 Do Not Represent a Major Etiological Factor of Primary Congenital Hypothyroidism in Mexican Population. ( 31061744 )
2019
8
Newborn Screening for Congenital Hypothyroidism in India: Let's Just Do It! ( 31064892 )
2019
9
An Optimal Capillary Screen Cut-off of Thyroid Stimulating Hormone for Diagnosing Congenital Hypothyroidism: Data from a Pilot Newborn Screening Program in Delhi. ( 31064895 )
2019
10
Congenital Hypothyroidism in Preterm Newborns: A Retrospective Study Arising from a Screening Program in Fars Province, Southwestern Iran. ( 31110637 )
2019
11
Cyclic alternating pattern in infants with congenital hypothyroidism. ( 30037585 )
2019
12
Developmental Screening of Children with Congenital Hypothyroidism Using Ages and Stages Questionnaires Test. ( 31037087 )
2019
13
Interactive Effects of Exercise, Sex Hormones, and Transient Congenital Hypothyroidism on Long-Term Potentiation in Hippocampal Slices of Rat Offspring. ( 31031899 )
2019
14
Congenital Hypothyroidism is Associated With Impairment of the Leptin Signaling Pathway in the Hypothalamus in Male Wistar Animals in Adult Life. ( 30943548 )
2019
15
Cochlear dysfunction evidenced by reduction of amplitude of otoacoustic responses in patients with congenital hypothyroidism. ( 30928865 )
2019
16
Novel non-synonymous mutations of PAX8 in a cohort of chinese with congenital hypothyroidism. ( 30888984 )
2019
17
Supratherapeutic maternal iodine supplementation during pregnancy as a cause for congenital hypothyroidism. ( 30746884 )
2019
18
Zebrafish duox mutations provide a model for human congenital hypothyroidism. ( 30700401 )
2019
19
Determining the TSH reference range in national newborn screening program for congenital hypothyroidism. ( 30700177 )
2019
20
An exonic splicing enhancer mutation in DUOX2 causes aberrant alternative splicing and severe congenital hypothyroidism in Bama pigs. ( 30651277 )
2019
21
The Evaluation of Etiological Distribution and the Rate of Congenital Hypothyroidism among the Cases Referred from National Screening Program. ( 30630811 )
2019
22
Optimal Timing of Repeat Newborn Screening for Congenital Hypothyroidism in Preterm Infants to Detect Delayed Thyroid-Stimulating Hormone Elevation. ( 30529133 )
2019
23
Thyroid scintigraphy in three-year-old children with congenital hypothyroidism in correlation with neonatal TSH. ( 30450534 )
2019
24
Congenital Hypothyroidism due to Oligogenic Mutations in Two Sudanese Families. ( 30375286 )
2019
25
Hepatic Hemangioendothelioma: A Rare Cause of Congenital Hypothyroidism. ( 30370481 )
2019
26
Normative Data for Thyroid Stimulating Hormone for Screening of Congenital Hypothyroidism: Correspondence. ( 30338455 )
2019
27
CONGENITAL HYPOTHYROIDISM AS A RISK FACTOR FOR CENTRAL HEARING PROCESS DISORDERS. ( 30183803 )
2019
28
Evaluation of the congenital hypothyroidism screening programme in Iran: a 3-year retrospective cohort study. ( 29540462 )
2019
29
Association between subclinical hypothyroidism and depression: an updated systematic review and meta-analysis. ( 30621645 )
2019
30
Thyroid diseases increased the risk of type 2 diabetes mellitus: A nation-wide cohort study. ( 31096476 )
2019
31
Relationship Between Hormonal Mechanisms Of Diabetes Mellitus And Hypothyroidism Post-Bariatric Surgery. ( 31038066 )
2019
32
Prevalence of hypothyroidism in patients with type 2 diabetes mellitus and hypertension in India: a cross-sectional observational study. ( 30936734 )
2019
33
Discrete Papular Lichen Myxedematosus and Scleromyxedema with Hypothyroidism: A Report of Two Cases. ( 31011315 )
2019
34
The influence of hypothyroidism and substitution treatment on thyroid hormone conversion ratios and rT3 concentration in patients with end-stage renal failure. ( 30480752 )
2019
35
Relationship between Hypothyroidism and Endometrial Cancer. ( 30705778 )
2019
36
Prevalence of thyroid diseases in familial adenomatous polyposis: a systematic review and meta-analysis. ( 29663106 )
2019
37
Comorbidity severity index as a new tool for assessment of co-existing diseases in patients with non-alcoholic fatty liver disease at the carbohydrate metabolism disorder background and concomitant subclinical hypothyroidism. ( 31055550 )
2019
38
Are hypothyroidism and hypogonadism clinically relevant in patients with malignant gliomas? A longitudinal trial in patients with glioma. ( 30712840 )
2019
39
Are hypothyroidism and hypogonadism clinically relevant in patients with malignant gliomas? A longitudinal trial in patients with glioma. ( 30389240 )
2019
40
Re: "Association Between Primary Hypothyroidism and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis" by Mantovani et al. (Thyroid 2018;28:1270-1284). ( 30652529 )
2019
41
Combination therapy of propranolol, levothyroxine, and liothyronine was effective in a case of severe consumptive hypothyroidism associated with infantile hepatic hemangioma. ( 30745728 )
2019
42
Hypothyroidism in patients with hepatocellular carcinoma receiving cabozantinib: an unassessed issue. ( 30648889 )
2019
43
Disruption of the Pituitary Circadian Clock Induced by Hypothyroidism and Hyperthyroidism: Consequences on Daily Pituitary Hormone Expression Profiles. ( 30747053 )
2019
44
Lithium can cause hyperthyroidism as well as hypothyroidism: A systematic review of an under-recognised association. ( 30841715 )
2019
45
Hypothyroidism to hyperthyroidism: an immunological pendulum swing from two extreme poles - a case series. ( 30954956 )
2019
46
MTHFR gene polymorphisms in hypothyroidism and hyperthyroidism among Jordanian females. ( 31066758 )
2019
47
Analysis of the protective effects of γ-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice. ( 30676163 )
2019
48
Linear and nonlinear analyses of heart rate variability following orthostatism in subclinical hypothyroidism. ( 30681577 )
2019
49
Protective effects of quercetin supplementation against short-term toxicity of cadmium-induced hematological impairment, hypothyroidism, and testicular disturbances in albino rats. ( 30697654 )
2019
50
Subclinical-Hypothyroidism: A Pathology in Evolution. ( 30700355 )
2019

Variations for Hypothyroidism

ClinVar genetic disease variations for Hypothyroidism:

6 (show all 19)
# Gene Variation Type Significance SNP ID Assembly Location
1 RET NM_020975.4(RET): c.2753T> C (p.Met918Thr) single nucleotide variant Pathogenic rs74799832 GRCh37 Chromosome 10, 43617416: 43617416
2 RET NM_020975.4(RET): c.2753T> C (p.Met918Thr) single nucleotide variant Pathogenic rs74799832 GRCh38 Chromosome 10, 43121968: 43121968
3 STAT1 NM_007315.3(STAT1): c.1154C> T (p.Thr385Met) single nucleotide variant Pathogenic rs587777630 GRCh37 Chromosome 2, 191851647: 191851647
4 STAT1 NM_007315.3(STAT1): c.1154C> T (p.Thr385Met) single nucleotide variant Pathogenic rs587777630 GRCh38 Chromosome 2, 190986921: 190986921
5 GNB1 NM_002074.4(GNB1): c.239T> C (p.Ile80Thr) single nucleotide variant Pathogenic rs752746786 GRCh37 Chromosome 1, 1737942: 1737942
6 GNB1 NM_002074.4(GNB1): c.239T> C (p.Ile80Thr) single nucleotide variant Pathogenic rs752746786 GRCh38 Chromosome 1, 1806503: 1806503
7 ADNP NM_015339.4(ADNP): c.2188C> T (p.Arg730Ter) single nucleotide variant Pathogenic rs886041116 GRCh37 Chromosome 20, 49509063: 49509063
8 ADNP NM_015339.4(ADNP): c.2188C> T (p.Arg730Ter) single nucleotide variant Pathogenic rs886041116 GRCh38 Chromosome 20, 50892526: 50892526
9 POGZ NM_015100.3(POGZ): c.402_409dupTGCCAATC (p.His137Leufs) duplication Likely pathogenic rs1057518799 GRCh38 Chromosome 1, 151430716: 151430723
10 POGZ NM_015100.3(POGZ): c.402_409dupTGCCAATC (p.His137Leufs) duplication Likely pathogenic rs1057518799 GRCh37 Chromosome 1, 151403192: 151403199
11 CHD7 NM_017780.3(CHD7): c.6892C> T (p.Gln2298Ter) single nucleotide variant Pathogenic rs1057518891 GRCh37 Chromosome 8, 61767038: 61767038
12 CHD7 NM_017780.3(CHD7): c.6892C> T (p.Gln2298Ter) single nucleotide variant Pathogenic rs1057518891 GRCh38 Chromosome 8, 60854479: 60854479
13 HUWE1 NM_031407.6(HUWE1): c.6485G> C (p.Arg2162Pro) single nucleotide variant Uncertain significance rs1556948950 GRCh37 Chromosome X, 53596615: 53596615
14 HUWE1 NM_031407.6(HUWE1): c.6485G> C (p.Arg2162Pro) single nucleotide variant Uncertain significance rs1556948950 GRCh38 Chromosome X, 53569655: 53569655
15 ARID1B; TMEM242; ZDHHC14 GRCh37/hg19 6q25.3(chr6: 156772218-157870875)x3 copy number gain Uncertain significance GRCh37 Chromosome 6, 156772218: 157870875
16 PAX8 NM_003466.4(PAX8): c.1011del (p.Val339Serfs) deletion Uncertain significance GRCh37 Chromosome 2, 113993046: 113993047
17 PAX8 NM_003466.4(PAX8): c.1011del (p.Val339Serfs) deletion Uncertain significance GRCh38 Chromosome 2, 113235470: 113235470
18 SCNN1A NM_001159576.1(SCNN1A): c.1604G> A (p.Arg535Gln) single nucleotide variant Uncertain significance GRCh37 Chromosome 12, 6458505: 6458505
19 SCNN1A NM_001159576.1(SCNN1A): c.1604G> A (p.Arg535Gln) single nucleotide variant Uncertain significance GRCh38 Chromosome 12, 6349339: 6349339

Expression for Hypothyroidism

Search GEO for disease gene expression data for Hypothyroidism.