Hypothyroidism disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HYP086 MIFTS: 68	Hypothyroidism Categories: Endocrine diseases, Fetal diseases, Immune diseases, Mental diseases, Metabolic diseases, Neuronal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Hypothyroidism

MalaCards integrated aliases for Hypothyroidism:

Name: Hypothyroidism ¹¹ ⁷⁵ ²⁸ ⁵³ ⁵ ⁴¹ ⁴³ ¹⁴ ¹⁶ ⁷¹ ³³

Thyroid Diseases ⁵³ ⁴¹ ⁷¹

Thyroid Insufficiency ¹¹

Dysfunction Thyroid ⁵³

Thyroid Dysfunction ⁷¹

Thyroid Deficiency ¹¹

Thyroid Disease ¹⁶

Classifications:

MalaCards categories:
Global: Rare diseases Metabolic diseases Fetal diseases
Anatomical: Endocrine diseases Neuronal diseases Immune diseases Mental diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Endocrine, nutritional and metabolic diseases

Disorders of other endocrine glands

Disorders of endocrine glands in diseases classified elsewhere

Disorders of thyroid gland in diseases classified elsewhere

Disorders of thyroid gland

Other disorders of thyroid

Disorder of thyroid, unspecified

Other specified disorders of thyroid

Other hypothyroidism

Hypothyroidism due to medicaments and other exogenous substances

Hypothyroidism, unspecified

Other specified hypothyroidism

ICD11: ³³

Endocrine, nutritional or metabolic diseases

Endocrine diseases

Disorders of the thyroid gland or thyroid hormones system

Hypothyroidism

Acquired hypothyroidism

Hypothyroidism due to medicaments or other exogenous substances

Hypothyroidism, unspecified

External Ids:

Disease Ontology ¹¹ DOID:1459

ICD9CM ³⁴ 244.9

MeSH ⁴³ D007037

NCIt ⁴⁹ C26800

SNOMED-CT ⁶⁸ 267465007

ICD10 ³¹ E00-E07 E03.2 E03.8 more

EFO ¹⁶ EFO_0004705 EFO_1000627

ICD11 ³³ 1722092627 1722092627/unspecified 471390091

UMLS ⁷¹ C0020676 C0040128 C0348024

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Summaries for Hypothyroidism

MedlinePlus: ⁴¹ Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. It is one of your endocrine glands, which make hormones. Thyroid hormones control the rate of many activities in your body. These include how fast you burn calories and how fast your heart beats. All of these activities are your body's metabolism. Thyroid problems include: Goiter - enlargement of the thyroid gland Hyperthyroidism - when your thyroid gland makes more thyroid hormones than your body needs Hypothyroidism - when your thyroid gland does not make enough thyroid hormones Thyroid cancer Thyroid nodules - lumps in the thyroid gland Thyroiditis - swelling of the thyroid To diagnose thyroid diseases, doctors use a medical history, physical exam, and thyroid tests. They sometimes also use a biopsy. Treatment depends on the problem, but may include medicines, radioiodine therapy, or thyroid surgery. Dept. of Health and Human Services Office on Women's Health

MalaCards based summary: Hypothyroidism, also known as thyroid diseases, is related to congenital hypothyroidism and hypothyroidism, congenital, nongoitrous, 1. An important gene associated with Hypothyroidism is RET (Ret Proto-Oncogene), and among its related pathways/superpathways are Thyroid stimulating hormone (TSH) signaling pathway and Thyroid hormones production and peripheral downstream signaling effects. The drugs Nitroprusside and Nitric Oxide have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and lymph node, and related phenotypes are Resistant to vaccinia virus (VACV-A4L) infection and homeostasis/metabolism

Disease Ontology: ¹¹ A thyroid gland disease which involves an underproduction of thyroid hormone.

Wikipedia: ⁷⁵ Hypothyroidism (also called underactive thyroid, low thyroid or hypothyreosis) is a disorder of the... more...

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Related Diseases for Hypothyroidism

Diseases in the Hypothyroidism family:

Congenital Hypothyroidism	Central Congenital Hypothyroidism
Hypothyroidism Due to Iodide Transport Defect	Rare Adult Hypothyroidism
Transient Congenital Hypothyroidism	Rare Hypothyroidism
Primary Congenital Hypothyroidism	Hypothyroidism Due to Deficient Transcription Factors Involved in Pituitary Development or Function
Congenital Hypothyroidism Due to Maternal Intake of Antithyroid Drugs	Transient Congenital Hypothyroidism Due to Maternal Factor
Transient Congenital Hypothyroidism Due to Neonatal Factor	Congenital Hypothyroidism Due to Transplacental Passage of Tsh-Binding Inhibitory Antibodies
Congenital Hypothyroidism Due to Developmental Anomaly

Diseases related to Hypothyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2030)

#	Related Disease	Score	Top Affiliating Genes
1	congenital hypothyroidism	33.7	TSHR TSHB TRHR TRH TPO TG
2	hypothyroidism, congenital, nongoitrous, 1	33.6	TSHR TSHB TG PAX8 IYD GLIS3
3	hypothyroidism, congenital, nongoitrous, 2	33.6	TSHR TG SLC26A4 PAX8 NKX2-1
4	hypothyroidism, central, with testicular enlargement	33.2	TSHB TRHR TRH
5	diabetes mellitus, neonatal, with congenital hypothyroidism	33.1	SLC5A5 IYD GLIS3
6	hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate	33.1	TSHR SLC26A4 PAX8 NKX2-1 IYD
7	hypothyroidism, congenital, nongoitrous, 4	33.1	TSHB TPO TG
8	pendred syndrome	33.0	TPO TG SLC5A5 SLC26A4 PAX8 IYD
9	hyperthyroidism	32.9	TSHR TRHR TRH TPO TG SERPINA7
10	postsurgical hypothyroidism	32.8	TSHR TPO TG
11	hashimoto thyroiditis	32.8	TSHR TPO TG SLC26A4 SERPINA7 RET
12	thyroid dyshormonogenesis 1	32.7	SLC5A5 PAX8
13	myxedema	32.7	TSHR TSHB TPO TG SERPINA7
14	iodine hypothyroidism	32.6	TSHR TPO TG
15	thyroid dyshormonogenesis 2a	32.6	TSHR TPO TG RET PAX8 NKX2-1
16	thyroid dyshormonogenesis 4	32.6	IYD DIO3
17	familial thyroid dyshormonogenesis	32.5	TPO TG SLC5A5 SERPINA7 IYD DIO3
18	graves disease 1	32.5	TSHR TRH TPO TG SLC5A5 SERPINA7
19	athyreosis	32.4	TSHR SLC26A4 PAX8 NKX2-5 NKX2-1
20	subacute thyroiditis	32.2	TSHR TPO TG SERPINA7
21	thyroid ectopia	32.2	PAX8 NKX2-5
22	goiter	32.1	TSHR TRH TPO TG SLC5A5 SLC26A4
23	thyroiditis	32.0	TSHR TSHB TPO TG SERPINA7 RET
24	graves' disease	32.0	TSHR TPO TG SERPINA7 PAX8
25	nontoxic goiter	31.4	TSHR TPO TG SERPINA7
26	adenoma	31.3	TSHR TSHB TRH TG RET
27	endemic goiter	31.2	TSHR TSHB TRH TPO TG SLC5A5
28	euthyroid sick syndrome	31.2	TRH TG SERPINA7 DIO3
29	turner syndrome	31.1	TPO TG SERPINA7
30	nodular goiter	31.1	TSHR TPO TG SLC5A5 RET
31	multinodular goiter	31.0	TSHR TRH TPO TG SLC5A5 SLC26A4
32	thyroid hormone resistance, generalized, autosomal dominant	31.0	TSHR TSHB TRH TG SERPINA7
33	differentiated thyroid carcinoma	31.0	RET PAX8 NKX2-1
34	celiac disease 1	30.9	TPO TG STAT1 IFNA1
35	graves ophthalmopathy	30.9	TSHR TG
36	plummer's disease	30.9	TSHR TPO TG SERPINA7
37	goiter, multinodular 1, with or without sertoli-leydig cell tumors	30.9	TPO TG
38	hyperthyroxinemia	30.8	TSHR TPO SERPINA7
39	thyroid crisis	30.8	TSHR TPO TG SERPINA7
40	neonatal thyrotoxicosis	30.7	TSHR TG DIO3
41	papillary carcinoma	30.6	TSHR TPO TG RET PAX8 NKX2-1
42	dyshormonogenic goiter	30.6	TG SLC5A5 SLC26A4 IYD
43	thyroid hormone resistance, selective pituitary	30.6	TSHB TRH TG SERPINA7
44	hypothalamic disease	30.6	TSHB TRH
45	autoimmune polyendocrine syndrome	30.6	TG STAT1 IFNA1
46	thyroid cancer, nonmedullary, 2	30.6	TSHR TG PAX8
47	suppurative thyroiditis	30.5	TSHR TPO TG SLC5A5
48	hypotropia	30.5	TSHR TPO
49	papillary thyroid microcarcinoma	30.4	TG NKX2-1
50	thyroid gland anaplastic carcinoma	30.4	TSHR TPO TG SLC5A5 SLC26A4 RET

Comorbidity relations with Hypothyroidism via Phenotypic Disease Network (PDN): (show top 50) (show all 152)

Active Peptic Ulcer Disease	Acute Cystitis
Acute Kidney Failure	Acute Pancreatitis
Allergic Rhinitis	Alzheimer Disease, Familial, 1
Anxiety	Aortic Valve Disease 1
Atypical Depressive Disorder	Autonomic Nervous System Disease
Basilar Artery Insufficiency	Benign Essential Hypertension
Bipolar Disorder	Borderline Personality Disorder
Bronchiectasis	Bronchitis
Bronchopneumonia	Celiac Disease 1
Cerebral Atherosclerosis	Cerebral Degeneration
Cerebrovascular Disease	Chronic Kidney Disease
Chronic Pulmonary Heart Disease	Communicating Hydrocephalus
Congenital Hypothyroidism	Conjunctivitis
Conn's Syndrome	Conversion Disorder
Cystitis	Decubitus Ulcer
Deficiency Anemia	Delusional Disorder
Dependent Personality Disorder	Dermatomycosis
Diabetes Insipidus	Diabetic Polyneuropathy
Dyshormonogenic Goiter	Dyskinesia of Esophagus
Dysthymic Disorder	Encephalopathy
Epilepsy, Focal, with Speech Disorder and with or Without Impaired Intellectual Development	Esophagitis
Familial Atrial Fibrillation	Female Breast Cancer
Female Stress Incontinence	Femoral Vein Thrombophlebitis
First-Degree Atrioventricular Block	Gastroesophageal Reflux
Generalized Anxiety Disorder	Generalized Atherosclerosis

Graphical network of the top 20 diseases related to Hypothyroidism:

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Symptoms & Phenotypes for Hypothyroidism

GenomeRNAi Phenotypes related to Hypothyroidism according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Resistant to vaccinia virus (VACV-A4L) infection	GR00351-A-1	9.17	GLIS3 GNB1 IFNA1 RET SERPINA7 SLC26A4

MGI Mouse Phenotypes related to Hypothyroidism:

⁴⁵ (show all 11)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.33	CHD7 DIO3 GLIS3 NKX2-1 NKX2-5 PAX8
2	growth/size/body region	MP:0005378	10.31	CHD7 DIO3 GLIS3 GNB1 NKX2-1 NKX2-5
3	nervous system	MP:0003631	10.27	CHD7 GNB1 NKX2-1 NKX2-5 PAX8 RET
4	endocrine/exocrine gland	MP:0005379	10.21	CHD7 GLIS3 NKX2-1 NKX2-5 PAX8 RET
5	limbs/digits/tail	MP:0005371	10.02	CHD7 PAX8 RET STAT1 TG TPO
6	cellular	MP:0005384	10	CHD7 DIO3 GLIS3 GNB1 NKX2-1 NKX2-5
7	hearing/vestibular/ear	MP:0005377	9.98	CHD7 PAX8 SLC26A4 SLC5A5 TG TPO
8	behavior/neurological	MP:0005386	9.97	CHD7 GNB1 NKX2-1 PAX8 RET SLC26A4
9	digestive/alimentary	MP:0005381	9.92	CHD7 NKX2-1 NKX2-5 RET SLC26A4 STAT1
10	reproductive system	MP:0005389	9.65	CHD7 DIO3 NKX2-1 PAX8 RET SLC26A4
11	skeleton	MP:0005390	9.36	CHD7 GNB1 NKX2-1 PAX8 SLC26A4 SLC5A5

Sources

Drugs & Therapeutics for Hypothyroidism

Drugs for Hypothyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 381)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Nitroprusside

Approved, Investigational

Phase 4

15078-28-1

11963622

Nitric Oxide

Approved

Phase 4

10102-43-9

145068

Hydroxocobalamin

Approved

Phase 4

13422-51-0

15589840 44475014

Levoleucovorin

Approved, Experimental, Investigational

Phase 4

68538-85-2, 58-05-9, 73951-54-9

149436 6006

Rabeprazole

Approved, Investigational

Phase 4

117976-89-3, 117976-90-6

5029

Pantoprazole

Approved

Phase 4

102625-70-7, 138786-67-1

4679

Dexlansoprazole

Approved, Investigational

Phase 4

138530-94-6

9578005

Esomeprazole

Approved, Investigational, Vet_approved

Phase 4

73590-58-6, 119141-88-7

9568614 4594

Lansoprazole

Approved, Investigational

Phase 4

103577-45-3

3883

Parathyroid hormone

Approved, Investigational

Phase 4

9002-64-6

Prednisolone phosphate

Approved, Vet_approved

Phase 4

302-25-0

Prednisolone acetate

Approved, Vet_approved

Phase 4

52-21-1

Prednisolone

Approved, Vet_approved

Phase 4

50-24-8

4894 5755

Prednisone

Approved, Vet_approved

Phase 4

53-03-2

5865

Methylprednisolone hemisuccinate

Approved

Phase 4

2921-57-5

1875

Methylprednisolone

Approved, Vet_approved

Phase 4

83-43-2

4159 6741

Codeine

Approved, Illicit

Phase 4

76-57-3, 6854-40-6

5284371 5362471

Diazepam

Approved, Illicit, Investigational, Vet_approved

Phase 4

439-14-5

3016

Lidocaine

Approved, Vet_approved

Phase 4

137-58-6

3676

Tramadol

Approved, Investigational

Phase 4

27203-92-5

33741 5523

Ropivacaine

Approved

Phase 4

84057-95-4

71273 175805

Magnesium sulfate

Approved, Investigational, Vet_approved

Phase 4

7487-88-9

Metformin

Approved

Phase 4

1115-70-4, 657-24-9

4091

Triamcinolone

Approved, Vet_approved

Phase 4

124-94-7

31307

Betamethasone

Approved, Vet_approved

Phase 4

378-44-9

9782

Leuprolide

Approved, Investigational

Phase 4

53714-56-0

657181

Benzocaine

Approved, Investigational

Phase 4

1994-09-7, 94-09-7

2337

Tannic acid

Approved

Phase 4

1401-55-4

16129878 16129778

Hyaluronic acid

Approved, Vet_approved

Phase 4

9004-61-9

53477741

Cyanocobalamin

Approved, Nutraceutical

Phase 4

68-19-9

24892734 16212801 44176380

D-Tyrosine

Approved, Experimental, Investigational, Nutraceutical

Phase 4

133585-56-5, 60-18-4, 556-02-5

1153 6057

(3-Carboxy-2-(R)-Hydroxy-Propyl)-Trimethyl-Ammonium

Experimental

Phase 4

461-06-3

Cobalamin

Experimental

Phase 4

13408-78-1

6857388

Prednisolone hemisuccinate

Experimental

Phase 4

2920-86-7

4897

Carboxymethylcellulose Sodium

Phase 4

Vasodilator Agents

Phase 4

Vitamin B12

Phase 4

Vitamin B 12

Phase 4

Anti-Ulcer Agents

Phase 4

Antacids

Phase 4

Proton Pump Inhibitors

Phase 4

Gastrointestinal Agents

Phase 4

Antineoplastic Agents, Hormonal

Phase 4

Antiemetics

Phase 4

Methylprednisolone Acetate

Phase 4

584547

Antitussive Agents

Phase 4

Methylene diphosphonate

Phase 4

Diphosphonates

Phase 4

Neuroprotective Agents

Phase 4

Technetium Tc 99m Medronate

Phase 4

Interventional clinical trials:

(show top 50) (show all 1014)

#	Name	Status	NCT ID	Phase	Drugs
1	The Beneficial Effect of L-Thyroxine Long -Term Replacement on Lipid Profiles and Atherosclerosis in Subclinical Hypothyroidism: A Prospective Study	Unknown status	NCT01831869	Phase 4	L-thyroxine
2	Efficacy and Safety of Levothyroxine (L-T4) Replacement on Exercise Capability in Chronic Systolic Heart Failure Patients With Subclinical Hypothyroidism: A 24-week, Multi-center, Open Label, Randomized, Parallel Group Trial	Unknown status	NCT03096613	Phase 4	Levothyroxine
3	What is the Optimal Serum TSH Concentration During Thyroxine Treatment for Primary Hypothyroidism? Effects of Fine Titration of Thyroxine Dosage on Wellbeing, Quality of Life and Cognitive Function	Unknown status	NCT00111735	Phase 4	Thyroxine
4	Beneficial Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism	Unknown status	NCT02316743	Phase 4	Levothyroxine supplementation
5	Thyroid Hormone Replacement for Hypothyroidism and Acute Myocardial Infarction	Unknown status	NCT02512978	Phase 4	Levothyroxine
6	Randomized Crossover Trial for the Evaluation of the Possible Effects in the Intestine of Two Different Pharmaceutical Forms of L - Thyroxine in Patients With Primary Acquired Hypothyroidism	Unknown status	NCT02917863	Phase 4	L-Thyroxine (tablet, per os);L-Thyroxine (oral drops, solution)
7	Effects of Thyroid Hormone Treatment on Mitochondrial Function, Ectopic Fat Accumulation, Insulin Sensitivity and Brown Adipose Tissue in Type 2 Diabetes Mellitus	Unknown status	NCT01379170	Phase 4	Euthyrox (levothyroxine)
8	Does Sodium Nitroprusside Infusion Affect Thyroidal Function in Patients Undergoing Coronary Artery Bypass Grafting, a Prospective Randomized Clinical Trial.	Unknown status	NCT00636584	Phase 4	sodium nitroprusside;placebo
9	Total Thyroidectomy With Harmonic Scalpel® Versus Standard Surgery. Open Multicentric Randomized Controlled Trial	Unknown status	NCT00385983	Phase 4
10	The Use of Lu177 in the Treatment of Progressive and Unresectable Metastatic Medullary Thyroid Cancer	Unknown status	NCT01915485	Phase 4
11	Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General anesthesia---a Randomized Control Double-Blind Clinical Trial	Unknown status	NCT02613806	Phase 4	Dexmeditomidine;normal saline
12	Efficacy of Dexmedetomidine for Cough Suppression During Anesthetic Emergence in Patients Undergoing Thyroid Surgery: A Randomized, Double Blinded, Controlled Trial	Unknown status	NCT03312413	Phase 4	Dexmedetomidine Hydrochloride;Normal Saline
13	Open-Label, Multi-Center, Randomized, Active-Controlled, Phase 4 Study of rAd-p53 Gene Mono-Therapy, With Concurrent Radioactive Iodine , or Combination With Surgery in Subjects With Advanced Malignant Thyroid Tumors	Unknown status	NCT00902122	Phase 4	rAd-p53 gene;p53 gene therapy
14	Thyroid Hormone Replacement for Subclinical Hypothyroidism (TRUST) - Subanalysis on Subclinical Hypothyroidism and Depression	Completed	NCT01853579	Phase 4	Levothyroxine;Placebo
15	Evaluation of Long-term Benefit-risk Profile of Levothyroxine Treatment in Children With Congenital Hypothyroidism: Influence of Initial Levothyroxine Dose on Neurodevelopmental, Growth, Cardiovascular and Skeletal Outcomes	Completed	NCT05371262	Phase 4	Levothyroxin
16	The Effect of Thyroid Hormone Therapy on Muscle Mass and Function in Older Adults With Subclinical Hypothyroidism - a Substudy of TRUST and IEMO Trials	Completed	NCT04354896	Phase 4	Levothyroxin;Placebo
17	Effect of T4-T3 Combination Therapy Versus T4 Monotherapy in Patients With Hypothyroidism,a Double Blind Randomized Cross-Over Study.	Completed	NCT00531713	Phase 4	Triiodothyronine
18	Assessing Quality of Life Changes Using Calcitonin in Patients With Hypothyroidism on Biochemical Replacement With Levothyroxine	Completed	NCT03342001	Phase 4	Calcitonin
19	Effect of Thyroid Hormone Replacement on Fatigability in Untreated Older Adults With Subclinical Hypothyroidism	Completed	NCT02500342	Phase 4	Levothyroxine;Placebo
20	Neurocognitive and Metabolic Effects of Mild Hypothyroidism	Completed	NCT00565864	Phase 4	L-thyroxine (L-T4)
21	A Randomised, Controlled, Crossover Study: Treatment With Thyroxin Compared to Thyroxin + Triiodothyronin in Patients With Secondary Hypothyroidism	Completed	NCT00360074	Phase 4	Thyroxin, Triiodothyronine
22	Multi-modal Effects of Thyroid Hormone Replacement for Untreated Older Adults With Subclinical Hypothyroidism; a Randomised Placebo-controlled Trial	Completed	NCT01660126	Phase 4	Levothyroxine;Placebo
23	Impact of Thyroid Hormone Replacement on Progression of Atherosclerosis : a Randomized Placebo-Controlled Trial in Older Adults With Subclinical Hypothyroidism.	Completed	NCT02832934	Phase 4	Levothyroxine;Placebo
24	Single-center, Randomized, Double-Blinded, Comparative Study of the Effectiveness of L-carnitine in Patients'Fatigue Degree Changing With Hypothyroidism Who Take Levothyroxine	Completed	NCT01769157	Phase 4	L-carnitine;Placebo
25	Impact of Thyroid Hormone Replacement on Cardiac Function: a Randomized Placebo-Controlled Trial in Older Adults With Subclinical Hypothyroidism	Completed	NCT02832960	Phase 4	Levothyroxine;Placebo
26	A Single-center Interventional Study to Verify Clinical Utility of the Quantitative and the Qualitative POC TSH Test Kits Compared With the Third Generation TSH Test Kit	Completed	NCT01921452	Phase 4
27	Iodine Intake & Status of Preschoolers Given Micronutrient Powder for 6 Months	Completed	NCT02280330	Phase 4
28	An Open-label Therapeutic Efficacy Study of Tirosint (Levothyroxine Sodium) Capsules in Thyroidectomized Patients Taking Proton Pump Inhibitors	Completed	NCT03094416	Phase 4	levothyroxine sodium capsule;Proton pump inhibitor (PPI);Levothyroxine Sodium (LT4) Tablets
29	A Dosimetry Study of Radioiodine (131-I) Uptake Following the Administration of Thyrogen and Hypothyroid States During Thyroid Hormone Withdrawal	Completed	NCT00001730	Phase 4	Thyrogen
30	Study of Optimal Replacement of Thyroxine in the Elderly (SORTED) SORTED 1 - a Randomised Controlled Trial (Pilot Study), SORTED 2 - Qualitative Interviews, SORTED 3 - Retrospective Cohort	Completed	NCT01647750	Phase 4	Levothyroxine
31	Bioequivalence of Two Levothyroxine Tablet Formulations in Healthy Indian Volunteers: A Single-dose, Randomized, Open-label, Crossover Study	Completed	NCT01536678	Phase 4	Levothyroxine
32	Randomized Controlled Trial of Preoperative Steroids in Autoimmune Thyroid Disease	Completed	NCT04542278	Phase 4	Prednisone
33	Minimizing Narcotic Analgesics After Thyroid or Parathyroid Surgery	Completed	NCT03469310	Phase 4	Acetaminophen 500Mg Cap;Tylenol #3 Oral Tablet;Tramadol
34	Multicentric Randomized Controlled Study of Percutaneous Laser Ablation Versus Follow Up in Benign Thyroid Nodules. Long Term Results	Completed	NCT00858104	Phase 4
35	Is the Routine Pressure Dressing After Thyroidectomy Necessary? A Prospective Randomized Controlled Study	Completed	NCT00400465	Phase 4
36	Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction: a Prospective Evaluation and Impact of Treatment	Completed	NCT02491008	Phase 4	Levothyroxine;Placebo
37	Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections	Completed	NCT01599273	Phase 4	subconjunctival triamcinolone injection
38	Is it Possible to Increase Quality of Life, Using Recombinant TSH Instead of Withdrawal of Thyroid Hormone Treatment, Before Iodine Uptake in Patients With Thyroid Cancer?	Completed	NCT00604318	Phase 4	rhTSH
39	Diagnostic Accuracy Study of Indocyanine Green for Parathyroid Perfusion Assessment	Completed	NCT03969108	Phase 4	Indocyanine Green
40	A Double-masked, Methylprednisolone-control, Efficacy and Safety Study of 99Tc-MDP for Thyroid Associated Ophthalmopathy.	Completed	NCT03948191	Phase 4	Methylprednisolone;99Tc-MDP(99Technetium-Methylenediphosphonate Injection)
41	A Randomized Comparative Study Between Liquid (Tirosint®-SOL) and Tablet Formulations of Levothyroxine in Neonates and Infants With Congenital Hypothyroidism	Recruiting	NCT05228184	Phase 4	Tirosint®-SOL;Levothyroxine Sodium
42	Type 2 Deiodinase Gene Polymorphism and the Treatment of Hypothyroidism Caused	Recruiting	NCT05247476	Phase 4	L-T4;L-T4+T3 (thyroid tablet)
43	Effect of Thyroid Replacement Therapy on Thyroid Structure in Patients With Subclinical Hypothyroidism	Recruiting	NCT04953195	Phase 4	Levothyroxine Sodium Tablets
44	A Prospective, Multicenter Observational Study to Evaluate Thyroid Function of Pediatric Subjects From Birth to 3 Years Exposed to ISOVUE® (Iopamidol Injection)	Recruiting	NCT03779906	Phase 4	Isovue
45	Comparison of Levothyroxine Formulation in Hypothyroid Patients With Enteral Feeding	Recruiting	NCT04878614	Phase 4	Levothyroxine Tablet;Levothyroxine Sodium
46	Intravenous Or Topical Lidocaine And Neuromonitoring in Thyroid Surgery (IOLANT Study)	Recruiting	NCT04574947	Phase 4	Intravenous lidocaine;Intravenous placebo
47	Effect of Tramadol on Postoperative Sore Throat in Thyroid Surgery Under General Anesthesia With Endotracheal Intubation: A Randomized Controlled Trial	Recruiting	NCT04991493	Phase 4	Tramadol hydrochloride
48	Discontinuation of Levothyroxine Therapy for Patients With Subclinical Hypothyroidism: a Pilot Randomized, Double-blinded, Placebo-controlled Study	Active, not recruiting	NCT04288115	Phase 4	Levothyroxine
49	Effects of Long-term L-thyroxine Replacement on Serum Lipid and Atherosclerosis in Patients With Hypothyroidism	Active, not recruiting	NCT01848171	Phase 4	L-thyroxine
50	A Phase 4, Randomized, Double-masked, Placebo-controlled, Multicenter Trial to Evaluate the Efficacy and Safety of TEPEZZA® in Treating Patients With Chronic (Inactive) Thyroid Eye Disease	Active, not recruiting	NCT04583735	Phase 4	Placebo

Search NIH Clinical Center for Hypothyroidism

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Kelp preparation

Cochrane evidence based reviews: hypothyroidism

Sources

Genetic Tests for Hypothyroidism

Genetic tests related to Hypothyroidism:

#	Genetic test	Affiliating Genes
1	Hypothyroidism ²⁸

Sources

Anatomical Context for Hypothyroidism

Organs/tissues related to Hypothyroidism:

MalaCards : Thyroid, Heart, Lymph Node, Eye, Pituitary, Brain, Breast

Sources

Publications for Hypothyroidism

Articles related to Hypothyroidism:

(show top 50) (show all 43193)

#	Title	Authors	PMID	Year
1	Age-specific serum thyrotropin reference range for the diagnosis of subclinical hypothyroidism and its association with lipid profiles in the elderly population. ⁶² ⁴¹	Ni W...Xu S	36463291	2022
2	Epworth sleepiness scale is associated with hypothyroidism in male patients with obstructive sleep apnea. ⁶² ⁴¹	Wang L...Zhang J	36465644	2022
3	Supplementation with myo-inositol and Selenium improves the clinical conditions and biochemical features of women with or at risk for subclinical hypothyroidism. ⁶² ⁴¹	Payer J...Vanuga P	36465640	2022
4	Masked CKD in hyperthyroidism and reversible CKD status in hypothyroidism. ⁶² ⁴¹	Uchiyama-Matsuoka N...Wada J	36425466	2022
5	Association of coal mine dust lung disease with Nodular thyroid disease in coal miners: A retrospective observational study in China. ⁶² ⁴¹	Zhao F...Yang L	36388340	2022
6	Whole-genome sequencing of patients with rare diseases in a national health system. ⁵	Turro E...Ouwehand WH	32581362	2020
7	Endocrine system after 2 years of COVID-19 vaccines: A narrative review of the literature. ⁴¹	Pezzaioli LC...Cappelli C	36440218	2022
8	Genetics and phenomics of hypothyroidism and thyroid dys- and agenesis due to PAX8 and TTF1 mutations. ⁵³ ⁶²	Montanelli L...Tonacchera M	20302910	2010
9	Genetics and phenomics of hypothyroidism and goiter due to thyroglobulin mutations. ⁵³ ⁶²	Targovnik HM...Rivolta CM	20093166	2010
10	Calcitonin screening and pentagastrin testing: predictive value for the diagnosis of medullary carcinoma in nodular thyroid disease. ⁵³ ⁶²	Herrmann BL...Mann K	20332126	2010
11	Runx2 deficiency in mice causes decreased thyroglobulin expression and hypothyroidism. ⁵³ ⁶²	Endo T...Kobayashi T	20375239	2010
12	Congenital hypothyroidism in a kitten resulting in decreased IGF-I concentration and abnormal liver function tests. ⁵³ ⁶²	Quante S...Reusch CE	20223692	2010
13	Genetics and phenomics of hypothyroidism and goiter due to TPO mutations. ⁵³ ⁶²	Ris-Stalpers C...Bikker H	20153806	2010
14	Genetics and phenomics of hypothyroidism and goiter due to NIS mutations. ⁵³ ⁶²	Spitzweg C...Morris JC	20153805	2010
15	Four patients with hypothyroid Graves' disease. ⁵³ ⁶²	Starrenburg-Razenberg AJ...Elte JW	20421660	2010
16	Dual oxidase, hydrogen peroxide and thyroid diseases. ⁵³ ⁶²	Ohye H...Sugawara M	20407074	2010
17	Biallelic p.R2223H mutation in the thyroglobulin gene causes thyroglobulin retention and severe hypothyroidism with subsequent development of thyroid carcinoma. ⁵³ ⁶²	Raef H...Shi Y	20089614	2010
18	Turner syndrome and schizophrenia: a further hint for the role of the X-chromosome in the pathogenesis of schizophrenic disorders. ⁵³ ⁶²	Roser P...Kawohl W	20218787	2010
19	Molecular analysis of congenital goitres with hypothyroidism caused by defective thyroglobulin synthesis. Identification of a novel c.7006C>T [p.R2317X] mutation and expression of minigenes containing nonsense mutations in exon 7. ⁵³ ⁶²	Machiavelli GA...Targovnik HM	19438905	2010
20	Environmental pollutants and the thyroid. ⁵³ ⁶²	Pearce EN...Braverman LE	19942155	2009
21	Broad clinical involvement in a family affected by the fragile X premutation. ⁵³ ⁶²	Chonchaiya W...Hagerman RJ	19996900	2009
22	Diagnosis and discrimination of autoimmune Graves' disease and Hashimoto's disease using thyroid-stimulating hormone receptor-containing recombinant proteoliposomes. ⁵³ ⁶²	Fukushima H...Yoshimura T	19914592	2009
23	Panhypopituitarism due to metastases to the hypothalamus and the pituitary resulting from primary breast cancer: a case report and review of the literature. ⁵³ ⁶²	Peppa M...Hadjidakis D	19933072	2009
24	Thyrotropin-stimulating hormone receptor gene analysis in pediatric patients with non-autoimmune subclinical hypothyroidism. ⁵³ ⁶²	Nicoletti A...Cassio A	19820021	2009
25	Congenital leptin deficiency and thyroid function. ⁵³ ⁶²	Paz-Filho G...Licinio J	19889232	2009
26	GH replacement in adults: interactions with other pituitary hormone deficiencies and replacement therapies. ⁵³ ⁶²	Filipsson H...Johannsson G	19684055	2009
27	[Clinical significance of apolipoprotein B-48 (apoB-48) in patients with thyroid disease]. ⁵³ ⁶²	Mugii S...Yamashita S	20030174	2009
28	Radioiodine ablation: when and how. ⁵³ ⁶²	Ambrosetti MC...Ferdeghini M	19910900	2009
29	More hypothyroidism and less hyperthyroidism with sufficient iodine nutrition compared to mild iodine deficiency--a comparative population-based study of older people. ⁵³ ⁶²	Andersen S...Laurberg P	19762181	2009
30	Subclinical hypothyroidism and autoimmune thyroiditis in pregnancy--a study in south Indian subjects. ⁵³ ⁶²	Gayathri R...Raghavan K	20329425	2009
31	Final diagnosis in children with subclinical hypothyroidism and mutation analysis of the thyroid peroxidase gene (TPO). ⁵³ ⁶²	Turkkahraman D...Bircan I	19960894	2009
32	The p.A2215D thyroglobulin gene mutation leads to deficient synthesis and secretion of the mutated protein and congenital hypothyroidism with wide phenotype variation. ⁵³ ⁶²	Pardo V...Medeiros-Neto G	19509106	2009
33	Ovarian hyper-stimulation syndrome after spontaneous conception. ⁵³ ⁶²	Lussiana C...Massobrio M	19499413	2009
34	Subclinical hypothyroidism in children and adolescents: a wide range of clinical, biochemical, and genetic factors involved. ⁵³ ⁶²	Rapa A...Bona G	19417038	2009
35	[Sarcoidosis associated with hypothyroidism due to thyrotropin-receptor blocking antibodies]. ⁵³ ⁶²	Schmidt J...Vanhille P	18930567	2009
36	[An investigation of BRAF mutation in papillary thyroid carcinoma and its clinical value]. ⁵³ ⁶²	Gong RX...Zhou B	19504446	2009
37	Growth hormone/insulin-like growth factor axis in patients with subclinical thyroid dysfunction. ⁵³ ⁶²	Akin F...Kaptanoglu B	19111490	2009
38	Type 2 iodothyronine deiodinase in skeletal muscle: effects of hypothyroidism and fasting. ⁵³ ⁶²	Heemstra KA...Visser TJ	19293265	2009
39	Effects of thyroxine replacement on serum creatinine and cystatin C in patients with primary and central hypothyroidism. ⁵³ ⁶²	Goede DL...Schmid C	19529992	2009
40	TSH receptor - autoantibody interactions. ⁵³ ⁶²	Rees Smith B...Furmaniak J	19530271	2009
41	[Sodium-iodine symporter in thyroid, normal and cancer tissues and its relation to nuclear medicine and to gene cloning treatment]. ⁵³ ⁶²	Foujilas C...Syrmos N	19675882	2009
42	Serum leptin in overt and subclinical hypothyroidism: effect of levothyroxine treatment and relationship to menopausal status and body composition. ⁵³ ⁶²	Teixeira PF...Vaisman M	19415994	2009
43	Persistence of goitre in children post-salt iodization in Islamic Republic of Iran: autoimmune status. ⁵³ ⁶²	Dabbaghmanesh MH...Omrani GR	19731774	2009
44	Evolution of sonographic appearance of the thyroid gland in children with Hashimoto's thyroiditis. ⁵³ ⁶²	Vlachopapadopoulou E...Michalacos S	19554808	2009
45	Mainly the younger hypothyroid patients are referred to hospital--evidence for referral bias. ⁵³ ⁶²	Carle A...Jorgensen T	18945587	2009
46	Influence of iodide excess and interferon-gamma on human primary thyroid cell proliferation, thyroglobulin secretion, and intracellular adhesion molecule-1 and human leukocyte antigen-DR expression. ⁵³ ⁶²	Kostic I...Curcio F	19265500	2009
47	Thyroid function and changes in ultrasound morphology during antiviral therapy with pegylated interferon and ribavirin in patients with chronic hepatitis C. ⁵³ ⁶²	Friedrich-Rust M...Bojunga J	19175874	2009
48	Cardiac troponin T is not increased in patients with hypothyroidism. ⁵³ ⁶²	Ness-Abramof R...Shenkman L	19356187	2009
49	An inactivating mutation within the first extracellular loop of the thyrotropin receptor impedes normal posttranslational maturation of the extracellular domain. ⁵³ ⁶²	Sura-Trueba S...de Roux N	18927215	2009
50	Effects of combined interferon alpha and ribavirin therapy on thyroid functions in patients with chronic hepatitis C. ⁵³ ⁶²	Nadeem A...Khan SA	19208310	2009

Sources

Genes for Hypothyroidism

Genes related to Hypothyroidism (4 elite genes):

(show top 50) (show all 112)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	RET	Ret Proto-Oncogene	Protein Coding	412.29	Pathogenic ⁵ DISEASES inferred ¹⁴ Novoseek inferred ⁵³	12517951
2	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	405.25	Pathogenic ⁵ DISEASES inferred ¹⁴
3	CHD7	Chromodomain Helicase DNA Binding Protein 7	Protein Coding	404.88	Pathogenic ⁵ DISEASES inferred ¹⁴
4	GNB1	G Protein Subunit Beta 1	Protein Coding	400	Pathogenic ⁵
5	TG	Thyroglobulin	Protein Coding	95.5	Likely pathogenic ⁵ DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications Summaries (show sections)	15014299 12721190 1424209 (more) 8050135 11148327 9790265 8966023 17978827 16184253 8777378 20375239 18631008 15769978 9588493 11389291 15387978 16296342 19337173 2258580 15687823 16405252 15761510 15243406 14763906 14565053 12542401 11041454 9881901 16187910 15604941 15751925 19509106 17823263 16394083 10404833 9707574 8837335 7883851 8325250 2149997 18945587 18095494 16543988 15350757 11729583 8936677 8778159 18363882 17060029 16676403 15572417 7621572 7695146 8263143 20089614 19438905 19762181 19554808 18332849 18075286 16628280 12915634 11257722 9198970 8196172 1726786 1696557 20093166 17956163 17053394 16704751 16261894 15689747 7868803 8327640 8094394 1472644 1348235 1987438 19910900 19265500 8733874 1727828 2254721 16806791 15670185 11874417 14764776 18243140 10984889 11228272 12022704 9508203 8388753 7539201 8957481 7528064 1752339 10229914 10483254 8722578 8058301 16936513 2256432 12444888 16772197 7527743 8697622 10999849 2318474 19939287 18787379 12553558 11438400 11272097 9868291 7994910 8157713 10987206 10403176 9068951 8548999 1619946 19079713 9398743 2092906 10745983 8124482 18019649 17785297 14696848 14981996 12782763 9284706 8543331 18052943 17506473 15203250 7749502 7829613 8306534 1284333 1385030 14633662 14669943 14557483 11519462 10940722 10433080 9411419 1951413 7549998 18029466 16042141 7569734 7833663 1867098
6	TPO	Thyroid Peroxidase	Protein Coding	61.59	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Summaries (show sections)	15958307 9508203 8808096 (more) 16756464 8296680 12404891 1541688 8058301 15116324 10468951 12459031 8864829 2256432 16843823 8691639 12930364 8691351 10433080 8732446 8067701 19939287 18690797 16571091 15952102 12869816 12516239 9333770 9177277 7831030 8027226 19675882 8710531 1284333 16704751 14974177 20108397 19537420 16107134 11327880 10745983 9797631 8033367 8124482 18230665 16253615 11148327 9774843 12536361 17042691 17032713 16761581 16042134 14669943 14557483 12487768 8157713 17646226 9441553 7549998 17190692 11078988 16042141 20329425 15853828 19960894 12663594 1668285 19731774 15623818 17444061 7544244 17470594 16647667 15387978 16827958 18237049 7711875 10433193 12864797 8094394 1472644 20153806 18466208 19142837 18372363 17504869 15745924 14565053 17252692 16566389 10084596 9827658 17284630 17465866 16261894 15988403 16357456 15799214 10681281 7695146 8196171 2133168 19554808 16645010 16405253 17060029 15290270 15117432 14960142 11129117 20421660 19942155 18945587 18095494 1717189 17823263 16728541 16728534 12855016 7868803 8327640 12014522 10468986 11853186 15316579 15826919 17291404 18936354 2387197 15320974 19175874 16895958 8948271 10634366 11720875 10826522 11765045 18451445 1702446 9062508 9703376 15649099
7	TSHR	Thyroid Stimulating Hormone Receptor	Protein Coding	56.28	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	19633293 7800013 11932312 (more) 7865983 8560629 19820021 18727713 17392608 18930567 10319947 9398703 9702065 18927215 12790806 19417038 12192541 17953807 1970827 8170469 19530271 17526952 11379397 9137702 19914592 19506388 16320156 8722576 14725684 17524032 1348235 17823263 12457447 18777457 10584424 16042141 16756464 17084554 17190692 1541688 8157713 7524135 16571091 1977696 1633635 10940722 10946858 11508827 11834424 18786338 12558129 14557483 14669943 15114790 14633662 15115450 18234558 18504673 16335676 14654350 10946859 9528975 11704987 10699420 7831030 17042691 7540542 7559863 9183516 9438142 10718823 7829613 9385128
8	NKX2-1	NK2 Homeobox 1	Protein Coding	50.69	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications Summaries (show sections)	10931427 9565498 16042141 (more) 11508827 10365677 20302910 11854319 18788921 19037882 17468187
9	SLC26A4	Solute Carrier Family 26 Member 4	Protein Coding	46.47	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	16042141 14557483 12533525 (more) 11573133 11932316 16914891 16791000 16260428
10	TSHB	Thyroid Stimulating Hormone Subunit Beta	Protein Coding	44.46	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications Summaries (show sections)	11297590 16804796 15297803 (more) 9039330 12566717 16396960 1971148
11	TRH	Thyrotropin Releasing Hormone	Protein Coding	43.99	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Summaries (show sections)	7682562 11569180 2109585 (more) 10999119 1906072 11508826 1425022 1605145 12528294 8050389 9194636 14684601 2149975 15328193 9745408 18951722 10646660
12	PAX8	Paired Box 8	Protein Coding	41.05	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	10769673 16042141 17468187 (more) 20302910 17437516
13	SLC5A5	Solute Carrier Family 5 Member 5	Protein Coding	37.54	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	16418213 20153805 16121204 (more) 18205108 11716040
14	SERPINA7	Serpin Family A Member 7	Protein Coding	35.03	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	7518657 19675882 10429016 (more) 1700701 8345439 7947028 18167471 9470003 8461623 7750195 2105860 19337173 1946285 11396440 2106883
15	IYD	Iodotyrosine Deiodinase	Protein Coding	33.6	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
16	IFNA1	Interferon Alpha 1	Protein Coding	33.52	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17376035 8995531 15780045 (more) 11344186 15855880 11335880 7515124 9309534 15860921 18760045 11982739 7806093 17515071 16633105 9243373 17983936 16557537 18029321 7645363 11517570 7883851 8667604 9447287 8709922 9973163 8963028 12553552 12930598 12481406 9214471 8832953 7889118 7824050 16006723 9580806 2121769 8837335 8545699 16249973 7755342 10937518 10802518 9459633 17389454 20299237 16460494 16842442 7548816 7725847 10967911 1558092 19208310 9617858 8266816 17718699 11598884 18376370 19140232 15505982 9011479 8128980 19881515 8424429 8077347 10080596 11335878
17	GLIS3	GLIS Family Zinc Finger 3	Protein Coding	33.07	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
18	DIO3	Iodothyronine Deiodinase 3	Protein Coding	31.83	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Summaries (show sections)	16131330 17628010 19293265 (more) 11844744 17891232 12364418 16405410
19	NKX2-5	NK2 Homeobox 5	Protein Coding	31.8	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)
20	TRHR	Thyrotropin Releasing Hormone Receptor	Protein Coding	29.59	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	11857914 14594554 9702078 (more) 9141550
21	NRGN	Neurogranin	Protein Coding	27.87	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Summaries (show sections)	12889141 7539519
22	SHBG	Sex Hormone Binding Globulin	Protein Coding	27.78	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8536064 10211604 15582279 (more) 18271685 12705335 16416346 11916278 2280997 7749500 14558918
23	PRL	Prolactin	Protein Coding	25.39	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	1605145 14611708 7753340 (more) 12705335 8768831 15584931 9699131 18506157 1486880 19933072 12580934 1740490 9485179 16915543 16785150 19634649 19347183 12528294 8811668 8040015 1519463 16879621 10435850 9438923 9194636 11587139 10626543 9572212 8736275 7779675 10671947 1873088 15559242 1680269 11949229 1778595 15253797 12388943
24	ADNP	Activity Dependent Neuroprotector Homeobox	Protein Coding	25	Likely pathogenic ⁵
25	POGZ	Pogo Transposable Element Derived With ZNF Domain	Protein Coding	25	Likely pathogenic ⁵
26	SLC33A1	Solute Carrier Family 33 Member 1	Protein Coding	25	Likely pathogenic ⁵	32581362
27	DUOXA2	Dual Oxidase Maturation Factor 2	Protein Coding	24.86	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
28	IGSF1	Immunoglobulin Superfamily Member 1	Protein Coding	24.24	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
29	DUOX2	Dual Oxidase 2	Protein Coding	24.15	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16134168 17684392 18765513 (more) 20407074
30	THRA	Thyroid Hormone Receptor Alpha	Protein Coding	23.72	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
31	LEP	Leptin	Protein Coding	23.68	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15129802 14514340 14616887 (more) 10224835 11549117 10354196 9226211 18466078 19889232 17693966 9699123 9437233 15863950 19415994 9141562 10197072
32	DIO2	Iodothyronine Deiodinase 2	Protein Coding	23.01	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	19293265 11598378 17891232
33	AIRE	Autoimmune Regulator	Protein Coding	22.8	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders (show sections)	11343230 10720083 19209622
34	FOXE1	Forkhead Box E1	Protein Coding	22.78	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16042141
35	PROP1	PROP Paired-Like Homeobox 1	Protein Coding	22.78	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11508826 12244277 15012608 (more) 15611819
36	POU1F1	POU Class 1 Homeobox 1	Protein Coding	22.52	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11508826 12244277 8768831 (more) 9485179 7920987 10626543 11847467 16505001 7593413
37	IGF1	Insulin Like Growth Factor 1	Protein Coding	22.11	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17121519 10941423 9689829 (more) 18450819 12585338 11762714 9623636 12795364 7682563 12892173 17431897 20223692 14974926 10714760 17429593 15879690 17644863 15762042 12213663 9768678 18553546
38	THRB	Thyroid Hormone Receptor Beta	Protein Coding	22.11	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15860414
39	APOB	Apolipoprotein B	Protein Coding	22.1	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	7760967 15631881 15485607 (more) 20030174 16789979 17148561 17578170 2222095 9132233
40	IGFBP3	Insulin Like Growth Factor Binding Protein 3	Protein Coding	21.98	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11762714 12666822 19064126 (more) 19111490 17121519 10941423 9689829 9623636 12585338 12795364 7682563
41	MED12	Mediator Complex Subunit 12	Protein Coding	21.35	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10898921 12216017 11424983 (more) 20218787 14582143
42	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	21.21	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10474127 2359396 7867699 (more) 16857299 1376685 9024213 8157713 11934221 17284646 15943755 10884188 1676840 12518251 11081258 16982589 14764755 20332126
43	GH1	Growth Hormone 1	Protein Coding	21.14	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	1360909 12388943 17426088 (more) 10097249 8768831 18059085 11598378 16984240 19684055 8875435 16033731 8961133 9439906
44	TBL1X	Transducin Beta Like 1 X-Linked	Protein Coding	21.05	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
45	IRS4	Insulin Receptor Substrate 4	Protein Coding	20.99	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
46	HESX1	HESX Homeobox 1	Protein Coding	20.23	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15611819
47	POMC	Proopiomelanocortin	Protein Coding	20.11	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12388943 1656833 7549143 (more) 16759040
48	CGA	Glycoprotein Hormones, Alpha Polypeptide	Protein Coding	20.06	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	18238999 16278261 19499413 (more) 15008254 12379999
49	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	20.03	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9231050 9828915 16034471 (more) 10197076 10215771
50	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	20	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	1951418 7536446 16429278 (more) 18341381 10752328 9380939 2103763

Sources

Variations for Hypothyroidism

ClinVar genetic disease variations for Hypothyroidism:

⁵ (show all 16)

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	GNB1	NM_002074.5(GNB1):c.239T>C (p.Ile80Thr)	SNV	Pathogenic	208722	rs752746786	GRCh37: 1:1737942-1737942 GRCh38: 1:1806503-1806503
2	RET	NM_020975.6(RET):c.2753T>C (p.Met918Thr)	SNV	Pathogenic	13919	rs74799832	GRCh37: 10:43617416-43617416 GRCh38: 10:43121968-43121968
3	CHD7	NM_017780.4(CHD7):c.6892C>T (p.Gln2298Ter)	SNV	Pathogenic	374090	rs1057518891	GRCh37: 8:61767038-61767038 GRCh38: 8:60854479-60854479
4	STAT1	NM_007315.4(STAT1):c.1154C>T (p.Thr385Met)	SNV	Pathogenic Pathogenic	144006	rs587777630	GRCh37: 2:191851647-191851647 GRCh38: 2:190986921-190986921
5	ADNP	NM_001282531.3(ADNP):c.2188C>T (p.Arg730Ter)	SNV	Likely Pathogenic	279598	rs886041116	GRCh37: 20:49509063-49509063 GRCh38: 20:50892526-50892526
6	POGZ	NM_015100.4(POGZ):c.402_409dup (p.His137fs)	DUP	Likely Pathogenic	373957	rs1057518799	GRCh37: 1:151403191-151403192 GRCh38: 1:151430715-151430716
7	TG	NM_003235.5(TG):c.5804del (p.Asn1935fs)	DEL	Likely Pathogenic	689597	rs1587618417	GRCh37: 8:133980155-133980155 GRCh38: 8:132967910-132967910
8	SLC33A1	NM_004733.4(SLC33A1):c.963+1G>A	SNV	Likely Pathogenic	812763	rs1266904735	GRCh37: 3:155560220-155560220 GRCh38: 3:155842431-155842431
9	SLC26A4	NM_000441.2(SLC26A4):c.1301C>A (p.Ala434Asp)	SNV	Uncertain Significance	591607	rs1035397261	GRCh37: 7:107334885-107334885 GRCh38: 7:107694440-107694440
10	overlap with 3 genes	GRCh37/hg19 6q25.3(chr6:156772218-157870875)x3	CN GAIN	Uncertain Significance	523303		GRCh37: 6:156772218-157870875 GRCh38:
11	HUWE1	NM_031407.7(HUWE1):c.6485G>C (p.Arg2162Pro)	SNV	Uncertain Significance	523539	rs1556948950	GRCh37: X:53596615-53596615 GRCh38: X:53569655-53569655
12	TSHR	NM_000369.5(TSHR):c.202C>T (p.Pro68Ser)	SNV	Uncertain Significance	437071	rs142063461	GRCh37: 14:81528523-81528523 GRCh38: 14:81062179-81062179
13	SCNN1A	NM_001038.6(SCNN1A):c.1427G>A (p.Arg476Gln)	SNV	Uncertain Significance	598965	rs72657556	GRCh37: 12:6458505-6458505 GRCh38: 12:6349339-6349339
14	PAX8	NM_003466.4(PAX8):c.1011del (p.Val339fs)	DEL	Uncertain Significance	598954	rs1558700308	GRCh37: 2:113993047-113993047 GRCh38: 2:113235470-113235470
15	TG	NM_003235.5(TG):c.2549T>A (p.Leu850Gln)	SNV	Uncertain Significance	1708411		GRCh37: 8:133900601-133900601 GRCh38: 8:132888356-132888356
16	CR1	NM_000651.6(CR1):c.6283C>A (p.His2095Asn)	SNV	Uncertain Significance	812547	rs1571590802	GRCh37: 1:207783021-207783021 GRCh38: 1:207609676-207609676

Sources

Expression for Hypothyroidism

Search GEO for disease gene expression data for Hypothyroidism.

Sources

Pathways for Hypothyroidism

Pathways related to Hypothyroidism according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Thyroid stimulating hormone (TSH) signaling pathway ⁷⁴	11.32	TSHR TSHB STAT1 GNB1
2	Thyroid hormones production and peripheral downstream signaling effects ⁷⁴	11.09	TSHR TSHB TRH SLC5A5 SLC26A4 IYD
3	Metabolism of amine-derived hormones ⁶⁶ Show member pathways Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) ⁶⁶ Regulation of thyroid hormone activity ⁶⁶ Thyroxine biosynthesis ⁶⁶	11.06	TSHB TPO SLC5A5 IYD DIO3
4	Thyroxine (thyroid hormone) production ⁷⁴	10.65	TSHR TRH TPO TG SLC5A5
5	Hormone ligand-binding receptors ⁶⁶	10.4	TSHR TSHB

Sources

GO Terms for Hypothyroidism

Biological processes related to Hypothyroidism according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	retina development in camera-type eye	GO:0060041	9.93	RET GNB1 CHD7
2	positive regulation of multicellular organism growth	GO:0040018	9.8	TSHR DIO3 CHD7
3	thyroid hormone generation	GO:0006590	9.8	TPO TG SLC5A5
4	cellular response to gonadotropin stimulus	GO:0071371	9.73	SLC5A5 PAX8
5	hormone biosynthetic process	GO:0042446	9.73	DIO3 TG TPO
6	thyroid-stimulating hormone signaling pathway	GO:0038194	9.67	TSHR PAX8
7	thyroid gland development	GO:0030878	9.56	TG PAX8 NKX2-5 NKX2-1
8	thyroid hormone metabolic process	GO:0042403	9.55	TG IYD DIO3
9	iodide transport	GO:0015705	9.1	TG SLC5A5 SLC26A4

Molecular functions related to Hypothyroidism according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	sequence-specific DNA binding	GO:0043565	9.63	STAT1 PAX8 NKX2-5 NKX2-1 GLIS3
2	iodide transmembrane transporter activity	GO:0015111	9.26	SLC5A5 SLC26A4
3	thyroid-stimulating hormone receptor activity	GO:0004996	8.92	TSHR PAX8