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MCID: HYP086
MIFTS: 63

Hypothyroidism

Categories: Endocrine diseases, Immune diseases, Metabolic diseases, Neuronal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Hypothyroidism

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MalaCards integrated aliases for Hypothyroidism:

Name: Hypothyroidism 12 76 29 55 6 43 44 15 73
Thyroid Diseases 55 43 73
Thyroid Insufficiency 12
Dysfunction Thyroid 55
Thyroid Dysfunction 73
Thyroid Deficiency 12

Classifications:

MalaCards categories:
Global: Rare diseases Metabolic diseases
Anatomical: Endocrine diseases Neuronal diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:1459
ICD9CM 35 244.9
MeSH 44 D007037
NCIt 50 C26800
SNOMED-CT 68 40930008
Sources

Summaries for Hypothyroidism

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MedlinePlus : 43 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. It is one of your endocrine glands, which make hormones. Thyroid hormones control the rate of many activities in your body. These include how fast you burn calories and how fast your heart beats. All of these activities are your body's metabolism. Thyroid problems include Goiter - enlargement of the thyroid gland Hyperthyroidism - when your thyroid gland makes more thyroid hormones than your body needs Hypothyroidism - when your thyroid gland does not make enough thyroid hormones Thyroid cancer Thyroid nodules - lumps in the thyroid gland Thyroiditis - swelling of the thyroid To diagnose thyroid diseases, doctors use a medical history, physical exam, and thyroid tests. They sometimes also use a biopsy. Treatment depends on the problem, but may include medicines, radioiodine therapy, or thyroid surgery. Dept. of Health and Human Services Office on Women's Health

MalaCards based summary : Hypothyroidism, also known as thyroid diseases, is related to hypothyroidism, congenital, nongoitrous, 2 and hypothyroidism, central, and testicular enlargement. An important gene associated with Hypothyroidism is RET (Ret Proto-Oncogene), and among its related pathways/superpathways are Aldosterone synthesis and secretion and G alpha (s) signalling events. The drugs Selenium and Iodine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and heart, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Disease Ontology : 12 A thyroid gland disease which involves an underproduction of thyroid hormone.

Wikipedia : 76 Hypothyroidism, also called underactive thyroid or low thyroid, is a disorder of the endocrine system in... more...

Sources

Related Diseases for Hypothyroidism

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Diseases in the Hypothyroidism family:

Congenital Hypothyroidism Central Congenital Hypothyroidism
Hypothyroidism Due to Iodide Transport Defect Hypothyroidism Due to Deficient Transcription Factors Involved in Pituitary Development or Function
Congenital Hypothyroidism Due to Maternal Intake of Antithyroid Drugs Congenital Hypothyroidism Due to Transplacental Passage of Maternal Tsh-Binding Inhibitory Antibodies

Diseases related to Hypothyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 850)
# Related Disease Score Top Affiliating Genes
1 hypothyroidism, congenital, nongoitrous, 2 34.3 NKX2-1 PAX8 SERPINA7 SLC26A4 TG TSHR
2 hypothyroidism, central, and testicular enlargement 34.1 DUOX2 DUOXA2 IGSF1 TRH TSHB
3 hypothyroidism, congenital, nongoitrous, 4 34.1 SERPINA7 TG TPO TRH TSHB
4 congenital hypothyroidism 34.1 DUOX2 DUOXA2 GLIS3 IYD NKX2-1 NKX2-5
5 postsurgical hypothyroidism 33.9 TG TRH TSHR
6 neonatal hypothyroidism 33.8 PAX8 SLC5A5 TG TPO TSHR
7 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 33.6 TG TPO
8 pendred syndrome 33.2 DUOX2 PAX8 SLC26A4 TG TPO
9 hashimoto thyroiditis 33.0 RET SLC26A4 TG TPO TSHB TSHR
10 myxedema 32.9 TG TPO TSHR
11 hyperthyroidism 32.5 SERPINA7 TG TPO TRH TSHR
12 graves' disease 32.3 SERPINA7 TG TPO TSHR
13 subacute thyroiditis 32.3 SERPINA7 TG TPO TSHR
14 thyroid crisis 32.1 SERPINA7 TG
15 thyroid gland disease 31.6 DUOXA2 NKX2-1 PAX8 RET SERPINA7 SLC26A4
16 familial thyroid dyshormonogenesis 31.5 DUOX2 DUOXA2 IYD SLC5A5 TG TPO
17 thyroid ectopia 31.4 NKX2-5 PAX8
18 athyreosis 31.4 NKX2-1 NKX2-5 PAX8 SLC26A4 TG TSHR
19 thyroiditis 31.0 RET SERPINA7 TG TPO TRH TSHB
20 goiter 30.8 DUOXA2 IYD NKX2-1 PAX8 SERPINA7 SLC26A4
21 graves disease 1 30.5 SERPINA7 TG TPO TRH TSHR
22 differentiated thyroid carcinoma 30.3 NKX2-1 PAX8 RET TG TPO TSHR
23 thyroid carcinoma, familial medullary 30.3 NKX2-1 RET TG
24 endemic goiter 30.2 SERPINA7 TG TPO TSHB TSHR
25 thyroid cancer 30.2 NKX2-1 PAX8 RET SLC26A4 SLC5A5 TG
26 thyroid hormone resistance, generalized, autosomal dominant 30.1 SERPINA7 TG TRH
27 plummer's disease 30.1 TG TPO
28 neonatal thyrotoxicosis 30.1 PAX8 TSHR
29 hyperthyroxinemia 30.0 SERPINA7 TPO TRH TSHR
30 struma ovarii 30.0 NKX2-1 RET TG TSHR
31 papillary thyroid microcarcinoma 29.9 NKX2-1 TG TSHR
32 nodular goiter 29.9 RET SLC5A5 TG TPO TSHR
33 papillary carcinoma 29.9 NKX2-1 PAX8 RET TG TPO TSHR
34 multinodular goiter 29.9 NKX2-1 PAX8 SLC26A4 TG TPO TSHR
35 pernicious anemia 29.8 TG TPO
36 goiter, multinodular 1, with or without sertoli-leydig cell tumors 29.7 TG TPO
37 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 29.7 TG TPO TSHR
38 toxic diffuse goiter 29.6 SERPINA7 TG TPO TRH TSHR
39 follicular adenoma 29.5 NKX2-1 PAX8 RET SLC26A4 TG TPO
40 hypothyroidism, congenital, nongoitrous, 1 12.6
41 choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction 12.5
42 central congenital hypothyroidism 12.4
43 hypothyroidism, congenital, nongoitrous, 5 12.4
44 hypothyroidism, congenital, nongoitrous, 6 12.4
45 diabetes mellitus, neonatal, with congenital hypothyroidism 12.4
46 hypothyroidism, congenital, nongoitrous, 3 12.4
47 ectodermal dysplasia, hypohidrotic, with hypothyroidism and ciliary dyskinesia 12.3
48 autoimmune thyroid disease 1 12.1
49 autoimmune thyroid disease 2 12.1
50 autoimmune thyroid disease 4 12.1

Comorbidity relations with Hypothyroidism via Phenotypic Disease Network (PDN): (show top 50) (show all 156)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Allergic Rhinitis Alzheimer Disease
Anxiety Aortic Valve Disease 1
Atypical Depressive Disorder Autonomic Nervous System Disease
Basilar Artery Insufficiency Benign Essential Hypertension
Bipolar Disorder Borderline Personality Disorder
Bronchiectasis Bronchitis
Bronchopneumonia Celiac Disease 1
Cerebral Atherosclerosis Cerebral Degeneration
Cerebrovascular Disease Chronic Kidney Failure
Chronic Myocardial Ischemia Chronic Pulmonary Heart Disease
Communicating Hydrocephalus Conjunctivitis
Conn's Syndrome Conversion Disorder
Cystitis Decubitus Ulcer
Deficiency Anemia Delusional Disorder
Dependent Personality Disorder Dermatomycosis
Diabetes Insipidus Diabetic Polyneuropathy
Dyshormonogenic Goiter Dyskinesia of Esophagus
Dysthymic Disorder Encephalopathy
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Esophagitis
Exophthalmos Familial Atrial Fibrillation
Female Breast Cancer Female Stress Incontinence
Femoral Vein Thrombophlebitis First-Degree Atrioventricular Block
Gastroesophageal Reflux Generalized Anxiety Disorder

Graphical network of the top 20 diseases related to Hypothyroidism:



Diseases related to Hypothyroidism
Sources

Symptoms & Phenotypes for Hypothyroidism

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MGI Mouse Phenotypes related to Hypothyroidism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.28 CHD7 DUOX2 GLIS3 IGSF1 NKX2-1 NKX2-5
2 growth/size/body region MP:0005378 10.22 CHD7 DUOX2 GLIS3 IGSF1 NKX2-1 NKX2-5
3 homeostasis/metabolism MP:0005376 10.17 CHD7 DUOX2 GLIS3 IGSF1 NKX2-1 NKX2-5
4 nervous system MP:0003631 9.97 ADNP CHD7 DUOX2 GNB1 IGSF1 NKX2-1
5 hearing/vestibular/ear MP:0005377 9.85 CHD7 DUOX2 PAX8 SLC26A4 TPO TSHR
6 limbs/digits/tail MP:0005371 9.8 CHD7 DUOXA2 PAX8 RET TG TPO
7 reproductive system MP:0005389 9.61 CHD7 DUOX2 IGSF1 NKX2-1 PAX8 RET
8 skeleton MP:0005390 9.28 CHD7 DUOX2 DUOXA2 NKX2-1 PAX8 SLC26A4
Sources

Drugs & Therapeutics for Hypothyroidism

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Drugs for Hypothyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 250)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Selenium Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 7782-49-2
2
Iodine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 7553-56-2 807
3
Leuprolide Approved, Investigational Phase 4 53714-56-0 657181 3911
4
leucovorin Approved Phase 4,Phase 3 58-05-9 6006 143
5
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
6
Iron Approved Phase 4,Phase 2,Phase 1 7439-89-6 23925
7
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 44475014
8
Copper Approved, Investigational Phase 4 7440-50-8 27099
9
Bexarotene Approved, Investigational Phase 4 153559-49-0 82146
10
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
11
Prednisone Approved, Vet_approved Phase 4,Phase 2 53-03-2 5865
12
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
13 Orange Approved Phase 4
14
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
15
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
16
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
17
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
18
Peginterferon alfa-2a Approved, Investigational Phase 4 198153-51-4 5360545
19
Ribavirin Approved Phase 4 36791-04-5 37542
20
Deferasirox Approved, Investigational Phase 4,Phase 2 201530-41-8 5493381
21
Salmon Calcitonin Approved, Investigational Phase 4 47931-85-1 16129616
22
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
23
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
24
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
25 Deslorelin Investigational, Vet_approved Phase 4 57773-65-6
26
Cobalamin Experimental Phase 4 13408-78-1 6438156
27
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
28
Calcitonin gene-related peptide Investigational Phase 4 83652-28-2
29 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
30 insulin Phase 4,Not Applicable
31 Insulin, Globin Zinc Phase 4,Not Applicable
32 Antioxidants Phase 4,Phase 2,Not Applicable
33 Trace Elements Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
34 Protective Agents Phase 4,Phase 3,Phase 2,Not Applicable
35 Micronutrients Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
36 Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
38 cadexomer iodine Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
39 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
40 Anti-Infective Agents, Local Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
41 Anti-Inflammatory Agents Phase 4,Phase 2,Not Applicable
42 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
43 Autonomic Agents Phase 4,Phase 2,Not Applicable
44 Antibodies Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
45 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
46 carnitine Phase 4
47 Cathartics Phase 4
48 Carboxymethylcellulose Sodium Phase 4
49 Laxatives Phase 4
50 Gastrointestinal Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 266)
# Name Status NCT ID Phase Drugs
1 Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism Unknown status NCT02316743 Phase 4 Levothyroxine supplementation
2 Thyroxine Titration Study Unknown status NCT00111735 Phase 4 Thyroxine
3 Thyroid Study Type 2 Diabetes Mellitus (T2DM) Unknown status NCT01379170 Phase 4 Euthyrox (levothyroxine)
4 Selenium Supplementation in Youths With Autoimmune Thyroiditis Unknown status NCT02644707 Phase 4
5 Thyroid Hormone Replacement for Subclinical Hypothyroidism Completed NCT01660126 Phase 4 Levothyroxine;Placebo
6 Growth Hormone and GnRH Agonist in Adolescents With Acquired Hypothyroidism Completed NCT00206375 Phase 4 Growth hormone;Growth hormone treatment and puberty
7 Neurocognitive and Metabolic Effects of Mild Hypothyroidism Completed NCT00565864 Phase 4 L-thyroxine (L-T4)
8 Effects of L-carnitine on Hypothyroidism Completed NCT01769157 Phase 4 L-carnitine;Placebo
9 Effect of T4-T3 Combination Therapy Versus T4 Monotherapy in Patients With Hypothyroidism Completed NCT00531713 Phase 4 Triiodothyronine
10 Phase 4 Study in Secondary Hypothyroidism: Body Weight Adapted Thyroxin Treatment and Triiodothyronine Supplementation Completed NCT00360074 Phase 4 Thyroxin, Triiodothyronine
11 Study of Radioiodine (131-I) Uptake Following Administration of Thyrogen and Hypothyroid States During Thyroid Hormone Withdrawal. Completed NCT00001730 Phase 4 Thyrogen
12 The TRUST Study - Depression Substudy Completed NCT01853579 Phase 4 Levothyroxine;Placebo
13 Study of Optimal Replacement of Thyroxine in the Elderly Completed NCT01647750 Phase 4 Levothyroxine;Levothyroxine
14 Bioequivalence of Two Levothyroxine Tablet Formulations in Healthy Indian Volunteers Completed NCT01536678 Phase 4 Levothyroxine;Levothyroxine
15 Study to Verify Clinical Utility of Point-of-Care (POC) Thyroid Stimulating Hormone (TSH) Test Kits as Compared to Third Generation TSH Test Kit Completed NCT01921452 Phase 4
16 The TRUST Trial - CardioVascular Imaging ECHO Completed NCT02832960 Phase 4 Levothyroxine;Placebo
17 The TRUST Study - CardioVascular Imaging IMT Completed NCT02832934 Phase 4 Levothyroxine;Placebo
18 Iodine Status of Preschoolers Given Micronutrient Powder for 6 Months Completed NCT02280330 Phase 4
19 Carbohydrate Metabolism Disorder Frequency in Hypertriglyceridemia Induced by Bexarotene of Cutaneous T Cell Lymphoma Completed NCT01569724 Phase 4
20 Short-term Prednisone to Treat STA Study(SPTSS) Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
21 Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction Completed NCT02491008 Phase 4 Levothyroxine;Placebo
22 Safety and Efficacy of Oral Mega Pulse Methylprednisolone in Severe Therapy Resistant Alopecia Areata Completed NCT01167946 Phase 4 methylprednisolone sodium succinate;methylprednisolone sodium succinate;methylprednisolone sodium succinate
23 Long-Term Growth and Skeletal Effects of Early Growth Hormone Treatment in Turner Syndrome Completed NCT00266656 Phase 4 Humatrope
24 A Triple Combination Therapy Study of Boceprevir, Pegasys and Copegus in Previously Untreated Patients With Genotype 1 Chronic Hepatitis C Completed NCT01591460 Phase 4 boceprevir;peginterferon alfa-2a [Pegasys];peginterferon alfa-2a [Pegasys];ribavirin (Copegus];ribavirin (Copegus]
25 Randomized Crossover Trial for the Evaluation of the Possible Effects in the Intestine of Two Different Pharmaceutical Forms of L - Thyroxine in Patients With Primary Acquired Hypothyroidism Recruiting NCT02917863 Phase 4 L-Thyroxine (tablet, per os);L-Thyroxine (oral drops, solution)
26 Mean Percentage of Levothyroxine Dosage Increase in Patients With Hypothyroidism Started on Enteral Feeding Recruiting NCT02577367 Phase 4 Levothyroxine
27 Hypothyroidism Treated With Calcitonin Recruiting NCT03342001 Phase 4 Calcitonin
28 Thyroid Hormone Replacement for Subclinical Hypothyroidism and Chronic Heart Failure (ThyroHeart-CHF) Recruiting NCT03096613 Phase 4 Levothyroxine
29 Thyroid Hormone Replacement for Hypothyroidism and Acute Myocardial Infarction(ThyroHeart-AMI) Recruiting NCT02512978 Phase 4 Levothyroxine
30 Thyroid Function of Pediatric Subjects Following Isovue® Administration Recruiting NCT03779906 Phase 4 Isovue
31 Levothyroxine Sodium in Thyroidectomized Patients Taking Proton Pump Inhibitors Recruiting NCT03094416 Phase 4 levothyroxine sodium capsule
32 Levothyroxine Replacement With Liquid Gel Capsules vs Tablets Post-thyroidectomy Recruiting NCT02946918 Phase 4 Levothyroxine
33 Effects of L-thyroxine Replacement on Serum Lipid and Atherosclerosis in Hypothyroidism Active, not recruiting NCT01848171 Phase 4 L-thyroxine
34 Effect of L-Thyroxine on Lipid Profiles and Atherosclerosis in Subclinical Hypothyroidism Active, not recruiting NCT01831869 Phase 4 L-thyroxine
35 Effect of Thyroid Hormone Replacement on Fatigability in Untreated Older Adults With Subclinical Hypothyroidism Active, not recruiting NCT02500342 Phase 4 Levothyroxine;Placebo
36 Pediatric Risk of Hypothyroidism With Iodinated Contrast Media Not yet recruiting NCT03631771 Phase 4 Iohexol;Iodixanol;Iopromide
37 Effects of Levothyroxine Treatment on Hemodynamic and Renal Functions in Subclinical Hypothyroidism Withdrawn NCT02186405 Phase 4 LEVOTHYROXINE
38 Levothyroxine in Pregnant SLE Patients Withdrawn NCT01276782 Phase 4 Levothyroxine
39 Effect of Deferasirox on Endocrine Complications in Subjects With Transfusion Dependent Thalassemia Withdrawn NCT02069886 Phase 4 deferasirox
40 Thyroxin Treatment in Sub Clinical Hypothyroidism, on the Apnea Hypopnea Index Score, Lipids and Highly Sensitive CRP Unknown status NCT01486667 Phase 3 levothyroxine;sugar pill
41 Early Levothyroxine Post Radioactive Iodine Unknown status NCT01950260 Phase 2, Phase 3 Levothyroxine
42 Levothyroxine Treatment for Subclinical Hypothyroidism After Head and Neck Surgery Unknown status NCT02548715 Phase 2, Phase 3 Levothyroxine;Placebo
43 The Prospective Study of Standard Treatment of Graves Disease Iodine 131 and Prevention of Adverse Reactions Unknown status NCT01204359 Phase 3
44 Medico-Economic Comparison of Four Strategies of Radioiodine Ablation in Thyroid Carcinoma Patients Unknown status NCT00435851 Phase 3 Thyrogen, thyroid hormone withdrawal, iode 131
45 Effects of Levothyroxine on Endothelial Function of Patients With Subclinical Hypothyroidism Completed NCT02090907 Phase 2, Phase 3 Levothyroxine;Placebo
46 Subclinical Hypothyroidism and Mind in the Elderly Completed NCT00921050 Phase 2, Phase 3 levothyroxine sodium;excipient without levothyroxine (placebo)
47 Thyroid Therapy for Mild Thyroid Deficiency in Pregnancy Completed NCT00388297 Phase 3 Levothyroxine;Placebo for Levothyroxine
48 Comparison of the Safety and Successful Ablation of Thyroid Remnant in Post-thyroidectomized Euthyroid Patients (i.e. Patients Administered Thyrogen) Versus Hypothyroid Patients (no Thyrogen) Following 131I Administration Completed NCT00196729 Phase 3 Thyrogen + Radioiodine (131I)
49 Assessing the Impact of the Early and Systematic Hormonal Replacement After Radio-isotopic Ablation of Graves'hyperthyroïdism on Quality of Life, Efficiency and Tolerance Completed NCT01295333 Phase 3 the early prophylactic introduction of low dose of LT4 (50 µg/d) at 15 days post-ablation;The initiation of LT4 as soon as the first biological signs of hypothyroidism.
50 Comparison of Different Doses of 131I in Severe Graves' Hyperthyroidism Completed NCT01039818 Phase 3

Search NIH Clinical Center for Hypothyroidism

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: hypothyroidism

Sources

Genetic Tests for Hypothyroidism

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Genetic tests related to Hypothyroidism:

# Genetic test Affiliating Genes
1 Hypothyroidism 29
Sources

Anatomical Context for Hypothyroidism

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MalaCards organs/tissues related to Hypothyroidism:

41
Thyroid, Testes, Heart, Pituitary, Brain, Bone, Liver
Sources

Publications for Hypothyroidism

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Articles related to Hypothyroidism:

(show top 50) (show all 4788)
# Title Authors Year
1
The prevalence and correlation between subclinical hypothyroidism and gall stone disease in Baghdad teaching hospital. ( 30546871 )
2019
2
Relatively high rate of postpartum thyroiditis in the Straits of Messina area. Predictivity of both postpartum thyroiditis and permanent hypothyroidism by performing, in the first trimester of gestation, thyroid ultrasonography and measurement of serum thyroperoxidase and thyroglobulin autoantibodies. ( 30555788 )
2019
3
Antiepileptic drugs are associated with central hypothyroidism. ( 30194856 )
2019
4
Mean high dose L-thyroxine treatment is efficient and safe to achieve a normal IQ in young adult patients with congenital hypothyroidism. ( 29325045 )
2018
5
A Japanese patient with congenital central hypothyroidism caused by a novel IGSF1 mutation. ( 29425110 )
2018
6
Distal renal tubular acidosis in two children with acquired hypothyroidism. ( 29716758 )
2018
7
Congenital Hypothyroidism. ( 29405999 )
2018
8
Does hypothyroidism augment sun-induced skin damage? ( 29962323 )
2018
9
Prevalence of subclinical hypothyroidism in adults visiting primary health-care setting in Riyadh. ( 29441159 )
2018
10
Incidence of congenital hypothyroidism in China: data from the national newborn screening program, 2013-2015. ( 29715190 )
2018
11
Relation of Subclinical Hypothyroidism is Associated With Cardiovascular Events and All-Cause Mortality in Adults With High Cardiovascular Risk. ( 29980273 )
2018
12
Massive pleural and pericardial effusion due to hypothyroidism in a patient with a surgically treated thyroid-stimulating hormone-producing pituitary adenoma. ( 29757110 )
2018
13
Abnormal expression of ephrin-A5 affects brain development of congenital hypothyroidism rats. ( 29762250 )
2018
14
Prevalence of thyroid diseases in familial adenomatous polyposis: a systematic review and meta-analysis. ( 29663106 )
2018
15
Phosphate binders as a cause of hypothyroidism in dialysis patients: practical indications from a review of the literature. ( 29966512 )
2018
16
microRNA-124-3p inhibits the progression of congenital hypothyroidism via targeting programmed cell death protein 6. ( 29805523 )
2018
17
The Combined Effects of Levothyroxine and Low Level Laser Therapy on Wound Healing in Hypothyroidism Male Rat Model. ( 29399303 )
2018
18
Increased risk for inflammatory bowel disease in congenital hypothyroidism supports the existence of a shared susceptibility factor. ( 29977049 )
2018
19
Does initial dosing of levothyroxine in infants with congenital hypothyroidism lead to frequent dose adjustments secondary to iatrogenic hyperthyroidism on follow-up? ( 29715192 )
2018
20
Subclinical Hypothyroidism and the Risk of Cardiovascular Disease and All-Cause Mortality: a Meta-Analysis of Prospective Cohort Studies. ( 29978767 )
2018
21
Permanent Decompensated Congenital Hypothyroidism in Newborns with Whole-Blood Thyroid-Stimulating Hormone Concentrations between 8 and 10 mU/L: The Case for Lowering the Threshold. ( 29804122 )
2018
22
Evaluation of renal function in subclinical hypothyroidism. ( 29403205 )
2018
23
Association of Hypothyroidism with All-cause Mortality: A Cohort Study in an Older Adult Population. ( 29947768 )
2018
24
Two Cases of Transiently Elevated Serum CEA Levels in Severe Hypothyroidism without Goiter. ( 29709954 )
2018
25
Primary Hypothyroidism Presenting as Bilateral Ovarian Torsion. ( 29396948 )
2018
26
Anesthetic considerations in a parturient with renal tubular acidosis and hypothyroidism undergoing cesarean delivery. ( 29029882 )
2018
27
A Novel Missense Mutation in the SLC5A5 Gene in a Sudanese Family with Congenital Hypothyroidism. ( 29759035 )
2018
28
The Protective effect of P7C3 against DNA and neuron damage in rat pups with congenital hypothyroidism. ( 29665652 )
2018
29
Severely low serum magnesium is associated with increased risks of positive anti-thyroglobulin antibody and hypothyroidism: A cross-sectional study. ( 29967483 )
2018
30
Biofortification of Cereals With Foliar Selenium and Iodine Could Reduce Hypothyroidism. ( 29951072 )
2018
31
c-Fos downregulation positively regulates EphA5 expression in a congenital hypothyroidism rat model. ( 29330744 )
2018
32
A 7-year study on the prevalence of congenital hypothyroidism in northern Iran. ( 29881532 )
2018
33
Pituitary 'pseudotumor': an under-recognised complication of undertreated primary hypothyroidism. ( 29950371 )
2018
34
Congenital Hypothyroidism Due to Dyshormonogenesis in 2 Siblings. ( 29450818 )
2018
35
The Effects of De-Whiskering and Congenital Hypothyroidism on The Development of Nitrergic Neurons in Rat Primary Somatosensory and Motor Cortices. ( 29633592 )
2018
36
Fetal goitrous hypothyroidism - easy to recognize, difficult to treat. Is a combined intraamniotic and intravenous L-thyroxine therapy an option? ( 29956299 )
2018
37
Short stature and hypothyroidism in a child with Nail-Patella Syndrome. A case report. ( 29664512 )
2018
38
The genetic characteristics of congenital hypothyroidism in China by comprehensive screening of 21 candidate genes. ( 29650690 )
2018
39
Growth Failure and Excessive Weight Gain in a 10 Year Old Male With Obesity: Approach to Diagnosis, Management, and Treatment of Acquired Hypothyroidism. ( 29971222 )
2018
40
Prevalence of hypothyroidism among patients with isthmus-preserved thyroid lobectomy. ( 29968481 )
2018
41
Massive pericardial effusion without cardiac tamponade due to subclinical hypothyroidism (Hashimoto's disease). ( 29778090 )
2018
42
Genetic and functional analysis of two missense<i>DUOX2</i>mutations in congenital hypothyroidism and goiter. ( 29435108 )
2018
43
Congenital Hypothyroidism Screening in Term Neonates using Umbilical Cord Blood TSH Values. ( 29911045 )
2018
44
Correction to: Metabolic Brain Network Analysis of Hypothyroidism Symptom Based on [<sup>18</sup>F]FDG-PET of Rats. ( 29931430 )
2018
45
Appraisal of clinical practice guidelines on the management of hypothyroidism in pregnancy using the Appraisal of Guidelines for Research and Evaluation II instrument. ( 29445919 )
2018
46
Circulating MiR-146a May be a Potential Biomarker of Coronary Heart Disease in Patients with Subclinical Hypothyroidism. ( 29357324 )
2018
47
The influence of thyroid diseases, diabetes mellitus, primary hyperparathyroidism, vitamin B12 deficiency and other comorbid autoimmune diseases on treatment outcome in patients with rheumatoid arthritis: An exploratory cohort study. ( 29794789 )
2018
48
Hypothyroidism and Hypoparathyroidism in Thalassemia Major Patients: A Study in Sistan and Baluchestan Province, Iran. ( 29868126 )
2018
49
Antidepressant-Resistant Depression in Patients With Comorbid Subclinical Hypothyroidism or High-Normal TSH Levels. ( 29961367 )
2018
50
Thyroid Hypoplasia in Congenital Hypothyroidism Associated with Thyroid Peroxidase Mutations. ( 29790453 )
2018
Sources

Variations for Hypothyroidism

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ClinVar genetic disease variations for Hypothyroidism:

6 (show all 13)
# Gene Variation Type Significance SNP ID Assembly Location
1 RET NM_020975.4(RET): c.2753T> C (p.Met918Thr) single nucleotide variant Pathogenic rs74799832 GRCh37 Chromosome 10, 43617416: 43617416
2 RET NM_020975.4(RET): c.2753T> C (p.Met918Thr) single nucleotide variant Pathogenic rs74799832 GRCh38 Chromosome 10, 43121968: 43121968
3 GNB1 NM_002074.4(GNB1): c.239T> C (p.Ile80Thr) single nucleotide variant Pathogenic rs752746786 GRCh37 Chromosome 1, 1737942: 1737942
4 GNB1 NM_002074.4(GNB1): c.239T> C (p.Ile80Thr) single nucleotide variant Pathogenic rs752746786 GRCh38 Chromosome 1, 1806503: 1806503
5 ADNP NM_001282531.2(ADNP): c.2188C> T (p.Arg730Ter) single nucleotide variant Pathogenic rs886041116 GRCh37 Chromosome 20, 49509063: 49509063
6 ADNP NM_001282531.2(ADNP): c.2188C> T (p.Arg730Ter) single nucleotide variant Pathogenic rs886041116 GRCh38 Chromosome 20, 50892526: 50892526
7 POGZ NM_015100.3(POGZ): c.402_409dupTGCCAATC (p.His137Leufs) duplication Likely pathogenic rs1057518799 GRCh38 Chromosome 1, 151430716: 151430723
8 POGZ NM_015100.3(POGZ): c.402_409dupTGCCAATC (p.His137Leufs) duplication Likely pathogenic rs1057518799 GRCh37 Chromosome 1, 151403192: 151403199
9 CHD7 NM_017780.3(CHD7): c.6892C> T (p.Gln2298Ter) single nucleotide variant Pathogenic rs1057518891 GRCh37 Chromosome 8, 61767038: 61767038
10 CHD7 NM_017780.3(CHD7): c.6892C> T (p.Gln2298Ter) single nucleotide variant Pathogenic rs1057518891 GRCh38 Chromosome 8, 60854479: 60854479
11 HUWE1 NM_031407.6(HUWE1): c.6485G> C (p.Arg2162Pro) single nucleotide variant Uncertain significance GRCh37 Chromosome X, 53596615: 53596615
12 HUWE1 NM_031407.6(HUWE1): c.6485G> C (p.Arg2162Pro) single nucleotide variant Uncertain significance GRCh38 Chromosome X, 53569655: 53569655
13 ARID1B; TMEM242; ZDHHC14 GRCh37/hg19 6q25.3(chr6: 156772218-157870875)x3 copy number gain Uncertain significance GRCh37 Chromosome 6, 156772218: 157870875
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Expression for Hypothyroidism

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Search GEO for disease gene expression data for Hypothyroidism.
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Pathways for Hypothyroidism

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Pathways related to Hypothyroidism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Aldosterone synthesis and secretion 37
Show member pathways
 12.37 DUOX2 DUOXA2 IYD PAX8 SERPINA7 SLC26A4
2
G alpha (s) signalling events 66
11.71 GNB1 TSHB TSHR
3
Human Thyroid Stimulating Hormone (TSH) signaling pathway 1
11.39 GNB1 PAX8 TSHB TSHR
4
Amine-derived hormones 66
Show member pathways
 11.16 DUOX2 IYD SLC5A5 TPO TSHB
5
Hormone ligand-binding receptors 66
10.44 TSHB TSHR
6
Thyroxine (Thyroid Hormone) Production 1
9.8 SLC5A5 TG TPO TRH TSHR
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GO Terms for Hypothyroidism

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Biological processes related to Hypothyroidism according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.65 DUOX2 IYD TPO
2 retina development in camera-type eye GO:0060041 9.63 CHD7 GNB1 RET
3 hormone-mediated signaling pathway GO:0009755 9.58 TRH TSHB TSHR
4 innervation GO:0060384 9.52 CHD7 RET
5 ventricular trabecula myocardium morphogenesis GO:0003222 9.51 CHD7 NKX2-5
6 hormone biosynthetic process GO:0042446 9.5 DUOX2 TG TPO
7 adult heart development GO:0007512 9.49 CHD7 NKX2-5
8 cellular response to gonadotropin stimulus GO:0071371 9.43 PAX8 SLC5A5
9 thyroid hormone metabolic process GO:0042403 9.43 DUOX2 IYD TG
10 thyroid-stimulating hormone signaling pathway GO:0038194 9.37 PAX8 TSHR
11 iodide transport GO:0015705 9.33 SLC26A4 SLC5A5 TG
12 thyroid hormone generation GO:0006590 9.26 DUOX2 IYD SLC5A5 TPO
13 thyroid gland development GO:0030878 9.02 DUOX2 NKX2-1 NKX2-5 PAX8 TG

Molecular functions related to Hypothyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.43 TG TRH TSHB
2 iodide transmembrane transporter activity GO:0015111 9.16 SLC26A4 SLC5A5
3 iodide peroxidase activity GO:0004447 8.96 IYD TPO
4 thyroid-stimulating hormone receptor activity GO:0004996 8.62 PAX8 TSHR
Sources

Sources for Hypothyroidism

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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