MCID: HYP086
MIFTS: 69

Hypothyroidism

Categories: Endocrine diseases, Immune diseases, Metabolic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Hypothyroidism

Summaries for Hypothyroidism

MedlinePlus : 42 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. It is one of your endocrine glands, which make hormones. Thyroid hormones control the rate of many activities in your body. These include how fast you burn calories and how fast your heart beats. All of these activities are your body's metabolism. Thyroid problems include Goiter - enlargement of the thyroid gland Hyperthyroidism - when your thyroid gland makes more thyroid hormones than your body needs Hypothyroidism - when your thyroid gland does not make enough thyroid hormones Thyroid cancer Thyroid nodules - lumps in the thyroid gland Thyroiditis - swelling of the thyroid To diagnose thyroid diseases, doctors use a medical history, physical exam, and thyroid tests. They sometimes also use a biopsy. Treatment depends on the problem, but may include medicines, radioiodine therapy, or thyroid surgery. Dept. of Health and Human Services Office on Women's Health

MalaCards based summary : Hypothyroidism, also known as thyroid diseases, is related to congenital hypothyroidism and hypothyroidism, congenital, nongoitrous, 2. An important gene associated with Hypothyroidism is RET (Ret Proto-Oncogene), and among its related pathways/superpathways are Allograft rejection and Pathways in cancer. The drugs tannic acid and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, pituitary and testes, and related phenotypes are behavior/neurological and endocrine/exocrine gland

Disease Ontology : 12 A thyroid gland disease which involves an underproduction of thyroid hormone.

Wikipedia : 74 Hypothyroidism, also called underactive thyroid or low thyroid, is a disorder of the endocrine system in... more...

Related Diseases for Hypothyroidism

Diseases in the Hypothyroidism family:

Congenital Hypothyroidism Central Congenital Hypothyroidism
Hypothyroidism Due to Iodide Transport Defect Rare Adult Hypothyroidism
Transient Congenital Hypothyroidism Rare Hypothyroidism
Primary Congenital Hypothyroidism Hypothyroidism Due to Deficient Transcription Factors Involved in Pituitary Development or Function
Congenital Hypothyroidism Due to Maternal Intake of Antithyroid Drugs Transient Congenital Hypothyroidism Due to Maternal Factor
Transient Congenital Hypothyroidism Due to Neonatal Factor Congenital Hypothyroidism Due to Transplacental Passage of Tsh-Binding Inhibitory Antibodies
Congenital Hypothyroidism Due to Developmental Anomaly

Diseases related to Hypothyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1647)
# Related Disease Score Top Affiliating Genes
1 congenital hypothyroidism 35.7 TSHR TSHB TRHR TPO TG SLC5A5
2 hypothyroidism, congenital, nongoitrous, 2 35.6 TSHR TPO TG SLC5A5 SLC26A4 SERPINA7
3 hypothyroidism, congenital, nongoitrous, 1 35.4 TSHR TG IYD
4 hypothyroidism, central, with testicular enlargement 35.4 TSHB TRHR TRH
5 central congenital hypothyroidism 35.3 TSHB TRHR
6 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 35.2 TSHR SLC26A4 PAX8 NKX2-1 IYD
7 postsurgical hypothyroidism 34.9 TRH TPO TG RET
8 primary congenital hypothyroidism 34.8 TSHR PAX8 NKX2-1
9 iodine hypothyroidism 34.7 TSHR TPO TG
10 transient congenital hypothyroidism 34.5 TSHR TPO
11 pendred syndrome 34.4 TPO TG SLC5A5 SLC26A4 PAX8 IYD
12 hashimoto thyroiditis 34.3 TSHR TSHB TPO TG SLC26A4 RET
13 rare hypothyroidism 34.2 STAT1 RET GNB1 CHD7 ADNP
14 myxedema 34.1 TSHR TPO TG SERPINA7
15 hyperthyroidism 34.0 TSHR TRHR TRH TPO TG SERPINA7
16 familial thyroid dyshormonogenesis 33.8 TPO TG SLC5A5 IYD
17 graves' disease 33.5 TSHR TPO TG SERPINA7 PAX8
18 subacute thyroiditis 33.3 TSHR TPO TG SERPINA7
19 thyroid crisis 33.3 TSHR TPO TG SERPINA7
20 athyreosis 32.9 TSHR TG SLC26A4 PAX8 NKX2-5 NKX2-1
21 goiter 32.6 TSHR TRH TPO TG SLC5A5 SLC26A4
22 thyroiditis 32.6 TSHR TSHB TRH TPO TG SLC26A4
23 thyroid ectopia 32.5 PAX8 NKX2-5
24 graves disease 1 32.3 TSHR TRH TPO TG SLC5A5 SERPINA7
25 thyroid carcinoma 32.2 TSHR TPO TG RET NKX2-1
26 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 32.2 TSHR TPO TG
27 thyroid gland disease 32.1 TSHR TSHB TRH TPO TG SLC5A5
28 adenoma 31.9 TSHR TRH TG RET
29 differentiated thyroid carcinoma 31.6 TSHR TPO TG RET PAX8 NKX2-1
30 endemic goiter 31.6 TSHR TSHB TPO TG SLC26A4 SERPINA7
31 exophthalmos 31.6 TSHR TPO TG
32 multinodular goiter 31.6 TSHR TPO TG SLC26A4 RET PAX8
33 nodular goiter 31.5 TSHR TPO TG SLC5A5 RET
34 hypoparathyroidism 31.4 TPO RET CHD7
35 hyperthyroxinemia 31.3 TSHR TRH TPO TG SERPINA7
36 euthyroid sick syndrome 31.3 TRH TG SERPINA7
37 papillary carcinoma 31.3 TSHR TPO TG RET PAX8 NKX2-1
38 plummer's disease 31.2 TSHR TPO TG
39 mechanical strabismus 31.2 TPO TG
40 turner syndrome 31.0 TPO TG SERPINA7
41 struma ovarii 30.9 TSHR TG RET NKX2-1
42 neonatal thyrotoxicosis 30.9 TSHR TG
43 papillary thyroid microcarcinoma 30.9 TSHR TG NKX2-1
44 dyshormonogenic goiter 30.9 SLC26A4 IYD
45 hypothalamic disease 30.8 TSHB TRH
46 acute thyroiditis 30.8 TPO TG SERPINA7 IYD
47 toxic diffuse goiter 30.8 TSHR TPO TG SERPINA7
48 thyroid malformation 30.8 PAX8 NKX2-5 NKX2-1
49 thyroid gland medullary carcinoma 30.8 TG RET PAX8
50 nontoxic goiter 30.8 TSHR TPO TG SERPINA7

Comorbidity relations with Hypothyroidism via Phenotypic Disease Network (PDN): (show top 50) (show all 150)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Allergic Rhinitis Alzheimer Disease
Anxiety Aortic Valve Disease 1
Atypical Depressive Disorder Autonomic Nervous System Disease
Basilar Artery Insufficiency Benign Essential Hypertension
Bipolar Disorder Borderline Personality Disorder
Bronchiectasis Bronchitis
Bronchopneumonia Celiac Disease 1
Cerebral Atherosclerosis Cerebral Degeneration
Cerebrovascular Disease Chronic Pulmonary Heart Disease
Communicating Hydrocephalus Conjunctivitis
Conn's Syndrome Conversion Disorder
Cystitis Decubitus Ulcer
Deficiency Anemia Delusional Disorder
Dependent Personality Disorder Dermatomycosis
Diabetes Insipidus Diabetic Polyneuropathy
Dyshormonogenic Goiter Dyskinesia of Esophagus
Dysthymic Disorder Encephalopathy
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Esophagitis
Exophthalmos Familial Atrial Fibrillation
Female Breast Cancer Female Stress Incontinence
Femoral Vein Thrombophlebitis First-Degree Atrioventricular Block
Gastroesophageal Reflux Generalized Anxiety Disorder
Generalized Atherosclerosis Goiter

Graphical network of the top 20 diseases related to Hypothyroidism:



Diseases related to Hypothyroidism

Symptoms & Phenotypes for Hypothyroidism

MGI Mouse Phenotypes related to Hypothyroidism:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.27 CHD7 GNB1 NKX2-1 PAX8 RET SLC26A4
2 endocrine/exocrine gland MP:0005379 10.25 CHD7 GLIS3 NKX2-1 NKX2-5 PAX8 RET
3 growth/size/body region MP:0005378 10.21 CHD7 GLIS3 GNB1 NKX2-1 NKX2-5 PAX8
4 homeostasis/metabolism MP:0005376 10.17 CHD7 GLIS3 NKX2-1 NKX2-5 PAX8 RET
5 digestive/alimentary MP:0005381 10.03 CHD7 NKX2-1 NKX2-5 RET SLC26A4 STAT1
6 nervous system MP:0003631 10 ADNP CHD7 GNB1 NKX2-1 NKX2-5 PAX8
7 limbs/digits/tail MP:0005371 9.8 CHD7 PAX8 RET STAT1 TG TPO
8 reproductive system MP:0005389 9.61 CHD7 NKX2-1 PAX8 RET SLC26A4 TG
9 skeleton MP:0005390 9.36 CHD7 GNB1 NKX2-1 PAX8 SLC26A4 SLC5A5

Drugs & Therapeutics for Hypothyroidism

Drugs for Hypothyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 562)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
tannic acid Approved Phase 4 1401-55-4
2
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
3
Nitroprusside Approved, Investigational Phase 4 15078-28-1 11963622
4
Nitric Oxide Approved Phase 4 10102-43-9 145068
5
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
6
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
7
Orlistat Approved, Investigational Phase 4 96829-58-2 3034010
8
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
9
Povidone-iodine Approved Phase 4 25655-41-8
10
Iron Approved, Experimental Phase 4 15438-31-0, 7439-89-6 27284 23925
11
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
12
Bexarotene Approved, Investigational Phase 4 153559-49-0 82146
13
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
14
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
15
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
16
Polyestradiol phosphate Approved Phase 4 28014-46-2
17
Acetaminophen Approved Phase 4 103-90-2 1983
18
Ibuprofen Approved Phase 4 15687-27-1 3672
19
Leuprolide Approved, Investigational Phase 4 53714-56-0 657181 3911
20
Peginterferon alfa-2b Approved Phase 4 99210-65-8, 215647-85-1
21
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
22
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
23
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
24
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
25
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
26
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
27 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
28
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
29
Citalopram Approved Phase 4 59729-33-8 2771
30
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
31
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
32
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
33
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
34
Ribavirin Approved Phase 4 36791-04-5 37542
35 Orange Approved Phase 4
36
Colchicine Approved Phase 4 64-86-8 2833 6167
37
Levetiracetam Approved Phase 4 102767-28-2 441341
38
Fosphenytoin Approved, Investigational Phase 4 93390-81-9 56339
39
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
40
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
41
Bisoprolol Approved Phase 4 66722-44-9 2405
42
Nimodipine Approved, Investigational Phase 4 66085-59-4 4497
43
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
44
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
45
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
46
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
47
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
48
Codeine Approved, Illicit Phase 4 76-57-3 5284371
49
Metformin Approved Phase 4 657-24-9 14219 4091
50
Ethanol Approved Phase 4 64-17-5 702

Interventional clinical trials:

(show top 50) (show all 1112)
# Name Status NCT ID Phase Drugs
1 Total Thyroidectomy With Harmonic Scalpel® Versus Standard Surgery. Open Multicentric Randomized Controlled Trial Unknown status NCT00385983 Phase 4
2 Beneficial Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism Unknown status NCT02316743 Phase 4 Levothyroxine supplementation
3 Randomized Crossover Trial for the Evaluation of the Possible Effects in the Intestine of Two Different Pharmaceutical Forms of L - Thyroxine in Patients With Primary Acquired Hypothyroidism Unknown status NCT02917863 Phase 4 L-Thyroxine (tablet, per os);L-Thyroxine (oral drops, solution)
4 Efficacy and Safety of Levothyroxine (L-T4) Replacement on Exercise Capability in Chronic Systolic Heart Failure Patients With Subclinical Hypothyroidism: A 24-week, Multi-center, Open Label, Randomized, Parallel Group Trial Unknown status NCT03096613 Phase 4 Levothyroxine
5 Does Sodium Nitroprusside Infusion Affect Thyroidal Function in Patients Undergoing Coronary Artery Bypass Grafting, a Prospective Randomized Clinical Trial. Unknown status NCT00636584 Phase 4 sodium nitroprusside;placebo
6 What is the Optimal Serum TSH Concentration During Thyroxine Treatment for Primary Hypothyroidism? Effects of Fine Titration of Thyroxine Dosage on Wellbeing, Quality of Life and Cognitive Function Unknown status NCT00111735 Phase 4 Thyroxine
7 Effects of Thyroid Hormone Treatment on Mitochondrial Function, Ectopic Fat Accumulation, Insulin Sensitivity and Brown Adipose Tissue in Type 2 Diabetes Mellitus Unknown status NCT01379170 Phase 4 Euthyrox (levothyroxine)
8 Open-Label, Multi-Center, Randomized, Active-Controlled, Phase 4 Study of rAd-p53 Gene Mono-Therapy, With Concurrent Radioactive Iodine , or Combination With Surgery in Subjects With Advanced Malignant Thyroid Tumors Unknown status NCT00902122 Phase 4 rAd-p53 gene;p53 gene therapy
9 Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General anesthesia---a Randomized Control Double-Blind Clinical Trial Unknown status NCT02613806 Phase 4 Dexmeditomidine;normal saline
10 Efficacy of Dexmedetomidine for Cough Suppression During Anesthetic Emergence in Patients Undergoing Thyroid Surgery: A Randomized, Double Blinded, Controlled Trial Unknown status NCT03312413 Phase 4 Dexmedetomidine Hydrochloride;Normal Saline;Dexmedetomidine Hydrochloride;Dexmedetomidine Hydrochloride
11 The Effect of Weight Loss With Orlistat or Sibutramine Administration , Hypocaloric Diet and Physical Exercise , on AMH Levels, in Women With Polycystic Ovary Syndrome Unknown status NCT01475019 Phase 4 Orlistat;Sibutramine
12 The Use of Lu177 in the Treatment of Progressive and Unresectable Metastatic Medullary Thyroid Cancer Unknown status NCT01915485 Phase 4
13 Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease Unknown status NCT02339142 Phase 4 intravenous corticosteroids (methylprednisolone)
14 Maintenance of Vitamin D Sufficiency With Oral Vitamin D Supplementation in Malaysian Women of Malay and Indian Ethnicity With Post Menopausal Osteoporosis Unknown status NCT02389179 Phase 4 Vitamin D3
15 The Monitor of Serum Prolactin Level and Related Clinical Observations Among Individuals With Schizophrenia Spectrum Illnesses in a 3 Months Aripiprazole Trial Unknown status NCT00468533 Phase 4 Aripiprazole
16 Effect of Thyroid Hormone Replacement on Fatigability in Untreated Older Adults With Subclinical Hypothyroidism Completed NCT02500342 Phase 4 Levothyroxine;Placebo
17 Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction: a Prospective Evaluation and Impact of Treatment Completed NCT02491008 Phase 4 Levothyroxine;Placebo
18 Neurocognitive and Metabolic Effects of Mild Hypothyroidism Completed NCT00565864 Phase 4 L-thyroxine (L-T4)
19 Impact of Thyroid Hormone Replacement on Cardiac Function: a Randomized Placebo-Controlled Trial in Older Adults With Subclinical Hypothyroidism Completed NCT02832960 Phase 4 Levothyroxine;Placebo
20 Impact of Thyroid Hormone Replacement on Progression of Atherosclerosis : a Randomized Placebo-Controlled Trial in Older Adults With Subclinical Hypothyroidism. Completed NCT02832934 Phase 4 Levothyroxine;Placebo
21 Estimation of Carbohydrate Metabolism Disorder Frequency in Hypertriglyceridemia Induced by Bexarotene Treatment of Cutaneous T Cell Lymphoma - Pilote Study Completed NCT01569724 Phase 4
22 A Dosimetry Study of Radioiodine (131-I) Uptake Following the Administration of Thyrogen and Hypothyroid States During Thyroid Hormone Withdrawal Completed NCT00001730 Phase 4 Thyrogen
23 Effect of T4-T3 Combination Therapy Versus T4 Monotherapy in Patients With Hypothyroidism,a Double Blind Randomized Cross-Over Study. Completed NCT00531713 Phase 4 Triiodothyronine
24 Concomitant Use of Growth Hormone and GnRH Agonist in Adolescent Patients With Acquired Hypothyroidism Completed NCT00206375 Phase 4 Growth hormone;Growth hormone treatment and puberty
25 A Randomised, Controlled, Crossover Study: Treatment With Thyroxin Compared to Thyroxin + Triiodothyronin in Patients With Secondary Hypothyroidism Completed NCT00360074 Phase 4 Thyroxin, Triiodothyronine
26 Single-center, Randomized, Double-Blinded, Comparative Study of the Effectiveness of L-carnitine in Patients'Fatigue Degree Changing With Hypothyroidism Who Take Levothyroxine Completed NCT01769157 Phase 4 L-carnitine;Placebo
27 Assessing Quality of Life Changes Using Calcitonin in Patients With Hypothyroidism on Biochemical Replacement With Levothyroxine Completed NCT03342001 Phase 4 Calcitonin
28 SWITCH OR ADD PEGYLATED-INTERFERON IN CHRONIC HEPATITIS B PATIENTS ON LONG TERM NUCLEOS(T)IDE THERAPY (SWAP TRIAL) Completed NCT01928511 Phase 4 peg-interferon alpha 2b, 1.5mcg/kg s/c given weekly;Nucleos(t)ide analogue therapy
29 A Double-masked, Methylprednisolone-control, Efficacy and Safety Study of 99Tc-MDP for Thyroid Associated Ophthalmopathy. Completed NCT03948191 Phase 4 Methylprednisolone;99Tc-MDP(99Technetium-Methylenediphosphonate Injection)
30 A Single-center Interventional Study to Verify Clinical Utility of the Quantitative and the Qualitative POC TSH Test Kits Compared With the Third Generation TSH Test Kit Completed NCT01921452 Phase 4
31 Study of Optimal Replacement of Thyroxine in the Elderly (SORTED) SORTED 1 - a Randomised Controlled Trial (Pilot Study), SORTED 2 - Qualitative Interviews, SORTED 3 - Retrospective Cohort Completed NCT01647750 Phase 4 Levothyroxine;Levothyroxine
32 Thyroid Hormone Replacement for Subclinical Hypothyroidism (TRUST) - Subanalysis on Subclinical Hypothyroidism and Depression Completed NCT01853579 Phase 4 Levothyroxine;Placebo
33 The Effect of Thyroid Hormone Therapy on Muscle Mass and Function in Older Adults With Subclinical Hypothyroidism - a Substudy of TRUST and IEMO Trials Completed NCT04354896 Phase 4 Levothyroxin;Placebo
34 Multi-modal Effects of Thyroid Hormone Replacement for Untreated Older Adults With Subclinical Hypothyroidism; a Randomised Placebo-controlled Trial Completed NCT01660126 Phase 4 Levothyroxine;Placebo
35 Is the Routine Pressure Dressing After Thyroidectomy Necessary? A Prospective Randomized Controlled Study Completed NCT00400465 Phase 4
36 Bioequivalence of Two Levothyroxine Tablet Formulations in Healthy Indian Volunteers: A Single-dose, Randomized, Open-label, Crossover Study Completed NCT01536678 Phase 4 Levothyroxine;Levothyroxine
37 Efficiency and Safety Study of Short-term Prednisone to Treat Moderate and Severe Subacute Thyroiditis Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
38 Diagnostic Accuracy Study of Indocyanine Green for Parathyroid Perfusion Assessment Completed NCT03969108 Phase 4 Indocyanine Green
39 Is it Possible to Increase Quality of Life, Using Recombinant TSH Instead of Withdrawal of Thyroid Hormone Treatment, Before Iodine Uptake in Patients With Thyroid Cancer? Completed NCT00604318 Phase 4 rhTSH
40 Iodine Intake & Status of Preschoolers Given Micronutrient Powder for 6 Months Completed NCT02280330 Phase 4
41 Multicentric Randomized Controlled Study of Percutaneous Laser Ablation Versus Follow Up in Benign Thyroid Nodules. Long Term Results Completed NCT00858104 Phase 4
42 Response to Peg-interferon and Ribavirin for the Treatment of HCV Infection in HIV Co-infected Patients, Implemented in Public Hospitals in Thailand Completed NCT02247440 Phase 4 Peg-interferon + ribavirin under HIV physician supervision
43 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
44 Safety Profile of Iodopovidone as an Agent for Pleurodesis in Malignant Pleural Effusion Completed NCT01670786 Phase 4
45 Safety and Efficacy of Oral Mega Pulse Methylprednisolone in Severe Therapy Resistant Alopecia Areata Completed NCT01167946 Phase 4 methylprednisolone sodium succinate;methylprednisolone sodium succinate;methylprednisolone sodium succinate
46 Levosimendan Efficacy Assessment by Cardiopulmonary Exercise Test (CPET) Completed NCT02261948 Phase 4 Levosimendan;Placebo
47 The Comparison of the Efficacy of Once and Twice Daily Colchicine Dosage in Pediatric Patients With Familial Mediterranean Fever: A Randomized Trial Completed NCT02602028 Phase 4 colchicine
48 IV Keppra in the Emergency Department for Prevention of Early Recurrent Seizures Completed NCT00510783 Phase 4 Keppra;Fosphenytoin;Dilantin
49 Improving Multivitamin Supplementation to Pregnant Women Completed NCT02300155 Phase 4 Pregvit®;Orifer F®
50 Bisoprolol Versus Corticosteroid and Bisoprolol Combination for Prophylaxis Against Atrial Fibrillation After on Pump Coronary Artery Bypass Surgery Completed NCT03800264 Phase 4 Bisoprolol

Search NIH Clinical Center for Hypothyroidism

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Kelp preparation

Cochrane evidence based reviews: hypothyroidism

Genetic Tests for Hypothyroidism

Genetic tests related to Hypothyroidism:

# Genetic test Affiliating Genes
1 Hypothyroidism 29

Anatomical Context for Hypothyroidism

MalaCards organs/tissues related to Hypothyroidism:

40
Thyroid, Pituitary, Testes, Heart, Brain, Liver, Bone

Publications for Hypothyroidism

Articles related to Hypothyroidism:

(show top 50) (show all 34132)
# Title Authors PMID Year
1
Association between hypothyroidism and chronic kidney disease observed among an adult population 55 years and older. 42 61
32332605 2020
2
Can hypothyroidism be a protective factor for hepatocellular carcinoma in cirrhosis? 42 61
32176089 2020
3
European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity. 42 61
31855556 2020
4
Subacute Thyroiditis After Sars-COV-2 Infection. 42
32436948 2020
5
A phase I/IIa double blind single institute trial of low dose sirolimus for Pendred syndrome/DFNB4. 42
32384426 2020
6
Case 15-2020: A 79-Year-Old Man with Hyponatremia and Involuntary Movements of the Arm and Face. 42
32402166 2020
7
Runx2 deficiency in mice causes decreased thyroglobulin expression and hypothyroidism. 61 54
20375239 2010
8
Genetics and phenomics of hypothyroidism and thyroid dys- and agenesis due to PAX8 and TTF1 mutations. 54 61
20302910 2010
9
Congenital hypothyroidism in a kitten resulting in decreased IGF-I concentration and abnormal liver function tests. 61 54
20223692 2010
10
Genetics and phenomics of hypothyroidism and goiter due to TPO mutations. 61 54
20153806 2010
11
Genetics and phenomics of hypothyroidism and goiter due to NIS mutations. 54 61
20153805 2010
12
Genetics and phenomics of hypothyroidism and goiter due to thyroglobulin mutations. 61 54
20093166 2010
13
Four patients with hypothyroid Graves' disease. 54 61
20421660 2010
14
Dual oxidase, hydrogen peroxide and thyroid diseases. 54 61
20407074 2010
15
Turner syndrome and schizophrenia: a further hint for the role of the X-chromosome in the pathogenesis of schizophrenic disorders. 61 54
20218787 2010
16
Biallelic p.R2223H mutation in the thyroglobulin gene causes thyroglobulin retention and severe hypothyroidism with subsequent development of thyroid carcinoma. 54 61
20089614 2010
17
Molecular analysis of congenital goitres with hypothyroidism caused by defective thyroglobulin synthesis. Identification of a novel c.7006C>T [p.R2317X] mutation and expression of minigenes containing nonsense mutations in exon 7. 61 54
19438905 2010
18
Broad clinical involvement in a family affected by the fragile X premutation. 54 61
19996900 2009
19
Environmental pollutants and the thyroid. 54 61
19942155 2009
20
Diagnosis and discrimination of autoimmune Graves' disease and Hashimoto's disease using thyroid-stimulating hormone receptor-containing recombinant proteoliposomes. 54 61
19914592 2009
21
Thyrotropin-stimulating hormone receptor gene analysis in pediatric patients with non-autoimmune subclinical hypothyroidism. 61 54
19820021 2009
22
Panhypopituitarism due to metastases to the hypothalamus and the pituitary resulting from primary breast cancer: a case report and review of the literature. 54 61
19933072 2009
23
Congenital leptin deficiency and thyroid function. 61 54
19889232 2009
24
[Clinical significance of apolipoprotein B-48 (apoB-48) in patients with thyroid disease]. 54 61
20030174 2009
25
GH replacement in adults: interactions with other pituitary hormone deficiencies and replacement therapies. 54 61
19684055 2009
26
Subclinical hypothyroidism and autoimmune thyroiditis in pregnancy--a study in south Indian subjects. 54 61
20329425 2009
27
More hypothyroidism and less hyperthyroidism with sufficient iodine nutrition compared to mild iodine deficiency--a comparative population-based study of older people. 54 61
19762181 2009
28
Radioiodine ablation: when and how. 61 54
19910900 2009
29
Final diagnosis in children with subclinical hypothyroidism and mutation analysis of the thyroid peroxidase gene (TPO). 61 54
19960894 2009
30
The p.A2215D thyroglobulin gene mutation leads to deficient synthesis and secretion of the mutated protein and congenital hypothyroidism with wide phenotype variation. 61 54
19509106 2009
31
Persistent hyperprolactinemia following mammoplasty: a rare association. 54 61
19634649 2009
32
Subclinical hypothyroidism in children and adolescents: a wide range of clinical, biochemical, and genetic factors involved. 54 61
19417038 2009
33
[Sarcoidosis associated with hypothyroidism due to thyrotropin-receptor blocking antibodies]. 54 61
18930567 2009
34
Ovarian hyper-stimulation syndrome after spontaneous conception. 54 61
19499413 2009
35
Growth hormone/insulin-like growth factor axis in patients with subclinical thyroid dysfunction. 54 61
19111490 2009
36
Type 2 iodothyronine deiodinase in skeletal muscle: effects of hypothyroidism and fasting. 54 61
19293265 2009
37
TSH receptor - autoantibody interactions. 61 54
19530271 2009
38
Effects of thyroxine replacement on serum creatinine and cystatin C in patients with primary and central hypothyroidism. 61 54
19529992 2009
39
Persistence of goitre in children post-salt iodization in Islamic Republic of Iran: autoimmune status. 61 54
19731774 2009
40
Serum leptin in overt and subclinical hypothyroidism: effect of levothyroxine treatment and relationship to menopausal status and body composition. 61 54
19415994 2009
41
[Sodium-iodine symporter in thyroid, normal and cancer tissues and its relation to nuclear medicine and to gene cloning treatment]. 54 61
19675882 2009
42
Evolution of sonographic appearance of the thyroid gland in children with Hashimoto's thyroiditis. 54 61
19554808 2009
43
Mainly the younger hypothyroid patients are referred to hospital--evidence for referral bias. 61 54
18945587 2009
44
Thyroid function and changes in ultrasound morphology during antiviral therapy with pegylated interferon and ribavirin in patients with chronic hepatitis C. 61 54
19175874 2009
45
Influence of iodide excess and interferon-gamma on human primary thyroid cell proliferation, thyroglobulin secretion, and intracellular adhesion molecule-1 and human leukocyte antigen-DR expression. 54 61
19265500 2009
46
Cardiac troponin T is not increased in patients with hypothyroidism. 61 54
19356187 2009
47
Effects of combined interferon alpha and ribavirin therapy on thyroid functions in patients with chronic hepatitis C. 61 54
19208310 2009
48
Functional studies of new TSH receptor (TSHr) mutations identified in patients affected by hypothyroidism or isolated hyperthyrotrophinaemia. 54 61
18727713 2009
49
Increased thrombin-activatable fibrinolysis inhibitor and decreased tissue factor pathway inhibitor in patients with hypothyroidism. 61 54
18958631 2009
50
Non-functioning pituitary adenomas: clinical feature, laboratorial and imaging assessment, therapeutic management and outcome. 54 61
19347183 2009