MCID: HYP086
MIFTS: 70

Hypothyroidism

Categories: Endocrine diseases, Immune diseases, Metabolic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Hypothyroidism

Summaries for Hypothyroidism

MedlinePlus : 43 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. It is one of your endocrine glands, which make hormones. Thyroid hormones control the rate of many activities in your body. These include how fast you burn calories and how fast your heart beats. All of these activities are your body's metabolism. Thyroid problems include Goiter - enlargement of the thyroid gland Hyperthyroidism - when your thyroid gland makes more thyroid hormones than your body needs Hypothyroidism - when your thyroid gland does not make enough thyroid hormones Thyroid cancer Thyroid nodules - lumps in the thyroid gland Thyroiditis - swelling of the thyroid To diagnose thyroid diseases, doctors use a medical history, physical exam, and thyroid tests. They sometimes also use a biopsy. Treatment depends on the problem, but may include medicines, radioiodine therapy, or thyroid surgery. Dept. of Health and Human Services Office on Women's Health

MalaCards based summary : Hypothyroidism, also known as thyroid diseases, is related to hypothyroidism, central, and testicular enlargement and hypothyroidism, congenital, nongoitrous, 2. An important gene associated with Hypothyroidism is RET (Ret Proto-Oncogene), and among its related pathways/superpathways are Allograft rejection and Aldosterone synthesis and secretion. The drugs tannic acid and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, pituitary and testes, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Disease Ontology : 12 A thyroid gland disease which involves an underproduction of thyroid hormone.

Wikipedia : 75 Hypothyroidism, also called underactive thyroid or low thyroid, is a disorder of the endocrine system in... more...

Related Diseases for Hypothyroidism

Diseases in the Hypothyroidism family:

Congenital Hypothyroidism Central Congenital Hypothyroidism
Hypothyroidism Due to Iodide Transport Defect Rare Adult Hypothyroidism
Transient Congenital Hypothyroidism Rare Hypothyroidism
Primary Congenital Hypothyroidism Hypothyroidism Due to Deficient Transcription Factors Involved in Pituitary Development or Function
Congenital Hypothyroidism Due to Maternal Intake of Antithyroid Drugs Transient Congenital Hypothyroidism Due to Maternal Factor
Transient Congenital Hypothyroidism Due to Neonatal Factor Congenital Hypothyroidism Due to Transplacental Passage of Tsh-Binding Inhibitory Antibodies
Congenital Hypothyroidism Due to Developmental Anomaly

Diseases related to Hypothyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1616)
# Related Disease Score Top Affiliating Genes
1 hypothyroidism, central, and testicular enlargement 35.3 TSHB TRH DUOXA2 DUOX2
2 hypothyroidism, congenital, nongoitrous, 2 35.3 TSHR TG SLC26A4 SERPINA7 PAX8 NKX2-1
3 hypothyroidism, congenital, nongoitrous, 4 35.1 TSHB TRH TPO TG SERPINA7
4 postsurgical hypothyroidism 35.0 TSHR TRH TG
5 congenital hypothyroidism 34.8 TSHR TSHB TPO TG SLC5A5 SLC26A4
6 pendred syndrome 34.3 TPO TG SLC26A4 PAX8 DUOX2
7 myxedema 34.1 TSHR TPO TG
8 hashimoto thyroiditis 34.0 TSHR TSHB TPO TG SLC26A4 RET
9 familial thyroid dyshormonogenesis 33.7 TPO TG SLC5A5 IYD DUOXA2 DUOX2
10 hyperthyroidism 33.7 TSHR TRH TPO TG SERPINA7
11 graves' disease 33.4 TSHR TPO TG SERPINA7
12 subacute thyroiditis 33.3 TSHR TPO TG SERPINA7
13 thyroid crisis 32.7 TG SERPINA7
14 athyreosis 32.7 TSHR TG SLC26A4 PAX8 NKX2-5 NKX2-1
15 thyroid ectopia 32.7 PAX8 NKX2-5
16 graves disease 1 32.2 TSHR TRH TPO TG SERPINA7
17 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 32.2 TSHR TPO TG
18 thyroiditis 32.2 TSHR TSHB TRH TPO TG SERPINA7
19 goiter 32.0 TSHR TRH TPO TG SLC5A5 SLC26A4
20 endemic goiter 31.5 TSHR TSHB TPO TG SERPINA7
21 multinodular goiter 31.5 TSHR TPO TG SLC26A4 PAX8 NKX2-1
22 differentiated thyroid carcinoma 31.3 TSHR TPO TG RET PAX8 NKX2-1
23 hyperthyroxinemia 31.3 TSHR TRH TPO SERPINA7
24 thyroid hormone resistance, generalized, autosomal dominant 31.3 TRH TG SERPINA7
25 nodular goiter 31.2 TSHR TPO TG SLC5A5 RET
26 thyroid gland disease 31.0 TSHR TSHB TRH TPO TG SLC5A5
27 neonatal thyrotoxicosis 31.0 TSHR PAX8
28 plummer's disease 31.0 TPO TG
29 papillary carcinoma 31.0 TSHR TPO TG RET PAX8 NKX2-1
30 papillary thyroid microcarcinoma 30.9 TSHR TG NKX2-1
31 dyshormonogenic goiter 30.9 TG SLC26A4 SERPINA7 DUOXA2 DUOX2
32 struma ovarii 30.8 TSHR TG RET NKX2-1
33 nontoxic goiter 30.8 TSHR TPO TG SERPINA7
34 toxic diffuse goiter 30.7 TSHR TRH TPO TG SERPINA7
35 hashimoto encephalopathy 30.6 TSHR TPO
36 pernicious anemia 30.6 TPO TG
37 thyroid carcinoma, familial medullary 30.5 TG RET NKX2-1
38 thyroid cancer, nonmedullary, 2 30.4 TSHR TPO TG RET PAX8 NKX2-1
39 ovarian germ cell teratoma 30.4 TG RET NKX2-1
40 fetal adenoma 30.4 TG NKX2-1
41 malignant struma ovarii 30.4 TG RET NKX2-1
42 premature menopause 30.2 TPO TG
43 follicular adenoma 30.1 TSHR TPO TG SLC26A4 RET PAX8
44 choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction 12.8
45 hypothyroidism, congenital, nongoitrous, 1 12.8
46 central congenital hypothyroidism 12.7
47 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 12.6
48 diabetes mellitus, neonatal, with congenital hypothyroidism 12.6
49 hypothyroidism, congenital, nongoitrous, 5 12.6
50 hypothyroidism, congenital, nongoitrous, 3 12.6

Comorbidity relations with Hypothyroidism via Phenotypic Disease Network (PDN): (show top 50) (show all 151)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Allergic Rhinitis Alzheimer Disease
Anxiety Aortic Valve Disease 1
Atypical Depressive Disorder Autonomic Nervous System Disease
Basilar Artery Insufficiency Benign Essential Hypertension
Bipolar Disorder Borderline Personality Disorder
Bronchiectasis Bronchitis
Bronchopneumonia Celiac Disease 1
Cerebral Atherosclerosis Cerebral Degeneration
Cerebrovascular Disease Chronic Pulmonary Heart Disease
Communicating Hydrocephalus Conjunctivitis
Conn's Syndrome Conversion Disorder
Cystitis Decubitus Ulcer
Deficiency Anemia Delusional Disorder
Dependent Personality Disorder Dermatomycosis
Diabetes Insipidus Diabetic Polyneuropathy
Dyshormonogenic Goiter Dyskinesia of Esophagus
Dysthymic Disorder Encephalopathy
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Esophagitis
Exophthalmos Familial Atrial Fibrillation
Female Breast Cancer Female Stress Incontinence
Femoral Vein Thrombophlebitis First-Degree Atrioventricular Block
Gastroesophageal Reflux Generalized Anxiety Disorder
Generalized Atherosclerosis Goiter

Graphical network of the top 20 diseases related to Hypothyroidism:



Diseases related to Hypothyroidism

Symptoms & Phenotypes for Hypothyroidism

MGI Mouse Phenotypes related to Hypothyroidism:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.3 CHD7 DUOX2 GLIS3 NKX2-1 NKX2-5 PAX8
2 growth/size/body region MP:0005378 10.25 CHD7 DUOX2 GLIS3 NKX2-1 NKX2-5 PAX8
3 homeostasis/metabolism MP:0005376 10.21 CHD7 DUOX2 GLIS3 NKX2-1 NKX2-5 PAX8
4 cellular MP:0005384 10.19 CHD7 GLIS3 GNB1 NKX2-1 NKX2-5 PAX8
5 digestive/alimentary MP:0005381 10.02 CHD7 NKX2-1 NKX2-5 RET SLC26A4 STAT1
6 mortality/aging MP:0010768 10 ADNP CHD7 GLIS3 GNB1 NKX2-1 NKX2-5
7 nervous system MP:0003631 9.97 ADNP CHD7 DUOX2 GNB1 NKX2-1 NKX2-5
8 limbs/digits/tail MP:0005371 9.92 CHD7 DUOXA2 PAX8 RET STAT1 TG
9 hearing/vestibular/ear MP:0005377 9.88 CHD7 DUOX2 PAX8 SLC26A4 TPO TSHR
10 reproductive system MP:0005389 9.56 CHD7 DUOX2 NKX2-1 PAX8 RET SLC26A4
11 skeleton MP:0005390 9.32 CHD7 DUOX2 DUOXA2 NKX2-1 PAX8 SLC26A4

Drugs & Therapeutics for Hypothyroidism

Drugs for Hypothyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 605)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
tannic acid Approved Phase 4 1401-55-4
2
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
3
Orlistat Approved, Investigational Phase 4 96829-58-2 3034010
4
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
5
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
6
leucovorin Approved Phase 4 58-05-9 143 6006
7
Iron Approved, Experimental Phase 4 15438-31-0, 7439-89-6 23925 27284
8
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
9
Bexarotene Approved, Investigational Phase 4 153559-49-0 82146
10
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
11
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
12
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
13
Polyestradiol phosphate Approved Phase 4 28014-46-2
14
Leuprolide Approved, Investigational Phase 4 53714-56-0 3911 657181
15
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
16
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
17
Peginterferon alfa-2b Approved Phase 4 99210-65-8, 215647-85-1
18
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
19
Citalopram Approved Phase 4 59729-33-8 2771
20
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
21
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
22
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
23
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
24
Ribavirin Approved Phase 4 36791-04-5 37542
25 Orange Approved Phase 4
26
Colchicine Approved Phase 4 64-86-8 6167 2833
27
Fosphenytoin Approved, Investigational Phase 4 93390-81-9 56339
28
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
29
Levetiracetam Approved, Investigational Phase 4 102767-28-2 441341
30
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
31
Bisoprolol Approved Phase 4 66722-44-9 2405
32
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
33
Norethindrone Approved Phase 4 68-22-4 6230
34
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
35
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
36
Acetaminophen Approved Phase 4 103-90-2 1983
37
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
38
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
39
Codeine Approved, Illicit Phase 4 76-57-3 5284371
40
Parathyroid hormone Approved, Investigational Phase 4 9002-64-6
41
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
42
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
43
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
44
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
45
Ethanol Approved Phase 4 64-17-5 702
46
Tranexamic Acid Approved Phase 4 1197-18-8 5526
47
Nimodipine Approved, Investigational Phase 4 66085-59-4 4497
48
Amiodarone Approved, Investigational Phase 4 1951-25-3 2157
49
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
50
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 22737-96-8, 11103-57-4, 68-26-8 9904001 445354

Interventional clinical trials:

(show top 50) (show all 1002)
# Name Status NCT ID Phase Drugs
1 Total Thyroidectomy With Harmonic Scalpel® Versus Standard Surgery. Open Multicentric Randomized Controlled Trial Unknown status NCT00385983 Phase 4
2 Beneficial Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism Unknown status NCT02316743 Phase 4 Levothyroxine supplementation
3 Randomized Crossover Trial for the Evaluation of the Possible Effects in the Intestine of Two Different Pharmaceutical Forms of L - Thyroxine in Patients With Primary Acquired Hypothyroidism Unknown status NCT02917863 Phase 4 L-Thyroxine (tablet, per os);L-Thyroxine (oral drops, solution)
4 What is the Optimal Serum TSH Concentration During Thyroxine Treatment for Primary Hypothyroidism? Effects of Fine Titration of Thyroxine Dosage on Wellbeing, Quality of Life and Cognitive Function Unknown status NCT00111735 Phase 4 Thyroxine
5 Effects of Thyroid Hormone Treatment on Mitochondrial Function, Ectopic Fat Accumulation, Insulin Sensitivity and Brown Adipose Tissue in Type 2 Diabetes Mellitus Unknown status NCT01379170 Phase 4 Euthyrox (levothyroxine)
6 Open-Label, Multi-Center, Randomized, Active-Controlled, Phase 4 Study of rAd-p53 Gene Mono-Therapy, With Concurrent Radioactive Iodine , or Combination With Surgery in Subjects With Advanced Malignant Thyroid Tumors Unknown status NCT00902122 Phase 4 rAd-p53 gene;p53 gene therapy
7 Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General anesthesia---a Randomized Control Double-Blind Clinical Trial Unknown status NCT02613806 Phase 4 Dexmeditomidine;normal saline
8 The Effect of Weight Loss With Orlistat or Sibutramine Administration , Hypocaloric Diet and Physical Exercise , on AMH Levels, in Women With Polycystic Ovary Syndrome Unknown status NCT01475019 Phase 4 Orlistat;Sibutramine
9 The Use of Lu177 in the Treatment of Progressive and Unresectable Metastatic Medullary Thyroid Cancer Unknown status NCT01915485 Phase 4
10 The Monitor of Serum Prolactin Level and Related Clinical Observations Among Individuals With Schizophrenia Spectrum Illnesses in a 3 Months Aripiprazole Trial Unknown status NCT00468533 Phase 4 Aripiprazole
11 Maintenance of Vitamin D Sufficiency With Oral Vitamin D Supplementation in Malaysian Women of Malay and Indian Ethnicity With Post Menopausal Osteoporosis Unknown status NCT02389179 Phase 4 Vitamin D3
12 Effect of Thyroid Hormone Replacement on Fatigability in Untreated Older Adults With Subclinical Hypothyroidism Completed NCT02500342 Phase 4 Levothyroxine;Placebo
13 Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction: a Prospective Evaluation and Impact of Treatment Completed NCT02491008 Phase 4 Levothyroxine;Placebo
14 Neurocognitive and Metabolic Effects of Mild Hypothyroidism Completed NCT00565864 Phase 4 L-thyroxine (L-T4)
15 Impact of Thyroid Hormone Replacement on Cardiac Function: a Randomized Placebo-Controlled Trial in Older Adults With Subclinical Hypothyroidism Completed NCT02832960 Phase 4 Levothyroxine;Placebo
16 Impact of Thyroid Hormone Replacement on Progression of Atherosclerosis : a Randomized Placebo-Controlled Trial in Older Adults With Subclinical Hypothyroidism. Completed NCT02832934 Phase 4 Levothyroxine;Placebo
17 Estimation of Carbohydrate Metabolism Disorder Frequency in Hypertriglyceridemia Induced by Bexarotene Treatment of Cutaneous T Cell Lymphoma - Pilote Study Completed NCT01569724 Phase 4
18 A Dosimetry Study of Radioiodine (131-I) Uptake Following the Administration of Thyrogen and Hypothyroid States During Thyroid Hormone Withdrawal Completed NCT00001730 Phase 4 Thyrogen
19 Effect of T4-T3 Combination Therapy Versus T4 Monotherapy in Patients With Hypothyroidism,a Double Blind Randomized Cross-Over Study. Completed NCT00531713 Phase 4 Triiodothyronine
20 Concomitant Use of Growth Hormone and GnRH Agonist in Adolescent Patients With Acquired Hypothyroidism Completed NCT00206375 Phase 4 Growth hormone;Growth hormone treatment and puberty
21 A Randomised, Controlled, Crossover Study: Treatment With Thyroxin Compared to Thyroxin + Triiodothyronin in Patients With Secondary Hypothyroidism Completed NCT00360074 Phase 4 Thyroxin, Triiodothyronine
22 Single-center, Randomized, Double-Blinded, Comparative Study of the Effectiveness of L-carnitine in Patients'Fatigue Degree Changing With Hypothyroidism Who Take Levothyroxine Completed NCT01769157 Phase 4 L-carnitine;Placebo
23 Assessing Quality of Life Changes Using Calcitonin in Patients With Hypothyroidism on Biochemical Replacement With Levothyroxine Completed NCT03342001 Phase 4 Calcitonin
24 SWITCH OR ADD PEGYLATED-INTERFERON IN CHRONIC HEPATITIS B PATIENTS ON LONG TERM NUCLEOS(T)IDE THERAPY (SWAP TRIAL) Completed NCT01928511 Phase 4 peg-interferon alpha 2b, 1.5mcg/kg s/c given weekly;Nucleos(t)ide analogue therapy
25 A Double-masked, Methylprednisolone-control, Efficacy and Safety Study of 99Tc-MDP for Thyroid Associated Ophthalmopathy. Completed NCT03948191 Phase 4 Methylprednisolone;99Tc-MDP(99Technetium-Methylenediphosphonate Injection)
26 A Single-center Interventional Study to Verify Clinical Utility of the Quantitative and the Qualitative POC TSH Test Kits Compared With the Third Generation TSH Test Kit Completed NCT01921452 Phase 4
27 Study of Optimal Replacement of Thyroxine in the Elderly (SORTED) SORTED 1 - a Randomised Controlled Trial (Pilot Study), SORTED 2 - Qualitative Interviews, SORTED 3 - Retrospective Cohort Completed NCT01647750 Phase 4 Levothyroxine;Levothyroxine
28 Thyroid Hormone Replacement for Subclinical Hypothyroidism (TRUST) - Subanalysis on Subclinical Hypothyroidism and Depression Completed NCT01853579 Phase 4 Levothyroxine;Placebo
29 Multi-modal Effects of Thyroid Hormone Replacement for Untreated Older Adults With Subclinical Hypothyroidism; a Randomised Placebo-controlled Trial Completed NCT01660126 Phase 4 Levothyroxine;Placebo
30 Is the Routine Pressure Dressing After Thyroidectomy Necessary? A Prospective Randomized Controlled Study Completed NCT00400465 Phase 4
31 Bioequivalence of Two Levothyroxine Tablet Formulations in Healthy Indian Volunteers: A Single-dose, Randomized, Open-label, Crossover Study Completed NCT01536678 Phase 4 Levothyroxine;Levothyroxine
32 Efficiency and Safety Study of Short-term Prednisone to Treat Moderate and Severe Subacute Thyroiditis Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
33 Is it Possible to Increase Quality of Life, Using Recombinant TSH Instead of Withdrawal of Thyroid Hormone Treatment, Before Iodine Uptake in Patients With Thyroid Cancer? Completed NCT00604318 Phase 4 rhTSH
34 Iodine Intake & Status of Preschoolers Given Micronutrient Powder for 6 Months Completed NCT02280330 Phase 4
35 Multicentric Randomized Controlled Study of Percutaneous Laser Ablation Versus Follow Up in Benign Thyroid Nodules. Long Term Results Completed NCT00858104 Phase 4
36 Response to Peg-interferon and Ribavirin for the Treatment of HCV Infection in HIV Co-infected Patients, Implemented in Public Hospitals in Thailand Completed NCT02247440 Phase 4 Peg-interferon + ribavirin under HIV physician supervision
37 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
38 Safety Profile of Iodopovidone as an Agent for Pleurodesis in Malignant Pleural Effusion Completed NCT01670786 Phase 4
39 Safety and Efficacy of Oral Mega Pulse Methylprednisolone in Severe Therapy Resistant Alopecia Areata Completed NCT01167946 Phase 4 methylprednisolone sodium succinate;methylprednisolone sodium succinate;methylprednisolone sodium succinate
40 Levosimendan Efficacy Assessment by Cardiopulmonary Exercise Test (CPET) Completed NCT02261948 Phase 4 Levosimendan;Placebo
41 The Comparison of the Efficacy of Once and Twice Daily Colchicine Dosage in Pediatric Patients With Familial Mediterranean Fever: A Randomized Trial Completed NCT02602028 Phase 4 colchicine
42 IV Keppra in the Emergency Department for Prevention of Early Recurrent Seizures Completed NCT00510783 Phase 4 Keppra;Fosphenytoin;Dilantin
43 Improving Multivitamin Supplementation to Pregnant Women Completed NCT02300155 Phase 4 Pregvit®;Orifer F®
44 Bisoprolol Versus Corticosteroid and Bisoprolol Combination for Prophylaxis Against Atrial Fibrillation After on Pump Coronary Artery Bypass Surgery Completed NCT03800264 Phase 4 Bisoprolol
45 Risperidone Augmentation for Treatment-Resistant Aggression in ADHD Completed NCT00297739 Phase 4 Risperidone
46 Long Term Efficacy and Tolerability of a Nutraceutical Combination (Red Yeast Rice, Policosanols and Berberine) in Low-moderate Risk Hypercholesterolemic Patients: a Double-blind, Placebo Controlled Study Completed NCT02078167 Phase 4
47 Reversal of an Unfavorable Effect of Hydrochlorothiazide Compared to Angiotensin Converting Enzyme Inhibitor on Serum Uric Acid and Oxypurines Levels by Estrogen-progestin Therapy in Hypertensive Postmenopausal Women. Completed NCT03921736 Phase 4 Perindopril;Hydrochlorothiazide;Estracomb TTS
48 Paroxetine-CR (Paxil-CR) in the Treatment of Patients With Fibromyalgia Syndrome: A Randomized, Double Blind, Parallel Group, Flexible Dose, Placebo Controlled Trial. Completed NCT00610610 Phase 4 Paroxetine CR;Placebo
49 Local Steroid Injection vs Wrist Splinting for Carpal Tunnel Syndrome: A Randomized Clinical Trial Completed NCT02140632 Phase 4
50 Antidepressant Treatment at an Inner City Asthma Clinic Completed NCT01324700 Phase 4 High severity group: Escitalopram;High severity group: Placebo;Low severity group: Escitalopram;Low severity group: Placebo

Search NIH Clinical Center for Hypothyroidism

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Kelp preparation
Levothyroxine
Liothyronine

Cochrane evidence based reviews: hypothyroidism

Genetic Tests for Hypothyroidism

Genetic tests related to Hypothyroidism:

# Genetic test Affiliating Genes
1 Hypothyroidism 29

Anatomical Context for Hypothyroidism

MalaCards organs/tissues related to Hypothyroidism:

41
Thyroid, Pituitary, Testes, Heart, Brain, Liver, Bone

Publications for Hypothyroidism

Articles related to Hypothyroidism:

(show top 50) (show all 33293)
# Title Authors PMID Year
1
Subclinical Hypothyroidism. 38 17
31287524 2019
2
Thyroid diseases increased the risk of type 2 diabetes mellitus: A nation-wide cohort study. 38 17
31096476 2019
3
Thyroid hormones treatment for subclinical hypothyroidism: a clinical practice guideline. 38 17
31088853 2019
4
Serum thyroglobulin elevation after needle aspiration of the lymph nodes: the predictive value for detecting metastasis in papillary thyroid cancer patients - a pilot study. 17
31374007 2019
5
The Role of Surgery in Autoimmune Conditions of the Thyroid. 17
31255196 2019
6
Diagnostic accuracy of different computer-aided diagnostic systems for malignant and benign thyroid nodules classification in ultrasound images: A systematic review and meta-analysis protocol. 17
31335673 2019
7
Genetics and phenomics of hypothyroidism and thyroid dys- and agenesis due to PAX8 and TTF1 mutations. 9 38
20302910 2010
8
Genetics and phenomics of hypothyroidism and goiter due to thyroglobulin mutations. 9 38
20093166 2010
9
Genetics and phenomics of hypothyroidism and goiter due to TPO mutations. 9 38
20153806 2010
10
Genetics and phenomics of hypothyroidism and goiter due to NIS mutations. 9 38
20153805 2010
11
Congenital hypothyroidism in a kitten resulting in decreased IGF-I concentration and abnormal liver function tests. 9 38
20223692 2010
12
Runx2 deficiency in mice causes decreased thyroglobulin expression and hypothyroidism. 9 38
20375239 2010
13
Four patients with hypothyroid Graves' disease. 9 38
20421660 2010
14
Dual oxidase, hydrogen peroxide and thyroid diseases. 9 38
20407074 2010
15
Biallelic p.R2223H mutation in the thyroglobulin gene causes thyroglobulin retention and severe hypothyroidism with subsequent development of thyroid carcinoma. 9 38
20089614 2010
16
Turner syndrome and schizophrenia: a further hint for the role of the X-chromosome in the pathogenesis of schizophrenic disorders. 9 38
20218787 2010
17
Molecular analysis of congenital goitres with hypothyroidism caused by defective thyroglobulin synthesis. Identification of a novel c.7006C>T [p.R2317X] mutation and expression of minigenes containing nonsense mutations in exon 7. 9 38
19438905 2010
18
Broad clinical involvement in a family affected by the fragile X premutation. 9 38
19996900 2009
19
Environmental pollutants and the thyroid. 9 38
19942155 2009
20
Diagnosis and discrimination of autoimmune Graves' disease and Hashimoto's disease using thyroid-stimulating hormone receptor-containing recombinant proteoliposomes. 9 38
19914592 2009
21
Panhypopituitarism due to metastases to the hypothalamus and the pituitary resulting from primary breast cancer: a case report and review of the literature. 9 38
19933072 2009
22
Thyrotropin-stimulating hormone receptor gene analysis in pediatric patients with non-autoimmune subclinical hypothyroidism. 9 38
19820021 2009
23
Congenital leptin deficiency and thyroid function. 9 38
19889232 2009
24
GH replacement in adults: interactions with other pituitary hormone deficiencies and replacement therapies. 9 38
19684055 2009
25
[Clinical significance of apolipoprotein B-48 (apoB-48) in patients with thyroid disease]. 9 38
20030174 2009
26
More hypothyroidism and less hyperthyroidism with sufficient iodine nutrition compared to mild iodine deficiency--a comparative population-based study of older people. 9 38
19762181 2009
27
Subclinical hypothyroidism and autoimmune thyroiditis in pregnancy--a study in south Indian subjects. 9 38
20329425 2009
28
Radioiodine ablation: when and how. 9 38
19910900 2009
29
Final diagnosis in children with subclinical hypothyroidism and mutation analysis of the thyroid peroxidase gene (TPO). 9 38
19960894 2009
30
The p.A2215D thyroglobulin gene mutation leads to deficient synthesis and secretion of the mutated protein and congenital hypothyroidism with wide phenotype variation. 9 38
19509106 2009
31
Persistent hyperprolactinemia following mammoplasty: a rare association. 9 38
19634649 2009
32
Ovarian hyper-stimulation syndrome after spontaneous conception. 9 38
19499413 2009
33
[Sarcoidosis associated with hypothyroidism due to thyrotropin-receptor blocking antibodies]. 9 38
18930567 2009
34
Subclinical hypothyroidism in children and adolescents: a wide range of clinical, biochemical, and genetic factors involved. 9 38
19417038 2009
35
Effects of thyroxine replacement on serum creatinine and cystatin C in patients with primary and central hypothyroidism. 9 38
19529992 2009
36
TSH receptor - autoantibody interactions. 9 38
19530271 2009
37
Growth hormone/insulin-like growth factor axis in patients with subclinical thyroid dysfunction. 9 38
19111490 2009
38
Type 2 iodothyronine deiodinase in skeletal muscle: effects of hypothyroidism and fasting. 9 38
19293265 2009
39
Serum leptin in overt and subclinical hypothyroidism: effect of levothyroxine treatment and relationship to menopausal status and body composition. 9 38
19415994 2009
40
Persistence of goitre in children post-salt iodization in Islamic Republic of Iran: autoimmune status. 9 38
19731774 2009
41
[Sodium-iodine symporter in thyroid, normal and cancer tissues and its relation to nuclear medicine and to gene cloning treatment]. 9 38
19675882 2009
42
Evolution of sonographic appearance of the thyroid gland in children with Hashimoto's thyroiditis. 9 38
19554808 2009
43
Mainly the younger hypothyroid patients are referred to hospital--evidence for referral bias. 9 38
18945587 2009
44
Influence of iodide excess and interferon-gamma on human primary thyroid cell proliferation, thyroglobulin secretion, and intracellular adhesion molecule-1 and human leukocyte antigen-DR expression. 9 38
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Thyroid function and changes in ultrasound morphology during antiviral therapy with pegylated interferon and ribavirin in patients with chronic hepatitis C. 9 38
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An inactivating mutation within the first extracellular loop of the thyrotropin receptor impedes normal posttranslational maturation of the extracellular domain. 9 38
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Involvement of CRH-R2 receptor in eating behavior and in the response of the HPT axis in rats subjected to dehydration-induced anorexia. 9 38
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Functional studies of new TSH receptor (TSHr) mutations identified in patients affected by hypothyroidism or isolated hyperthyrotrophinaemia. 9 38
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Effects of combined interferon alpha and ribavirin therapy on thyroid functions in patients with chronic hepatitis C. 9 38
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