Categories: Endocrine diseases, Immune diseases, Metabolic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Hypothyroidism

Summaries for Hypothyroidism

MedlinePlus : 42 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. It is one of your endocrine glands, which make hormones. Thyroid hormones control the rate of many activities in your body. These include how fast you burn calories and how fast your heart beats. All of these activities are your body's metabolism. Thyroid problems include Goiter - enlargement of the thyroid gland Hyperthyroidism - when your thyroid gland makes more thyroid hormones than your body needs Hypothyroidism - when your thyroid gland does not make enough thyroid hormones Thyroid cancer Thyroid nodules - lumps in the thyroid gland Thyroiditis - swelling of the thyroid To diagnose thyroid diseases, doctors use a medical history, physical exam, and thyroid tests. They sometimes also use a biopsy. Treatment depends on the problem, but may include medicines, radioiodine therapy, or thyroid surgery. Dept. of Health and Human Services Office on Women's Health

MalaCards based summary : Hypothyroidism, also known as thyroid diseases, is related to congenital hypothyroidism and hypothyroidism, congenital, nongoitrous, 2. An important gene associated with Hypothyroidism is RET (Ret Proto-Oncogene), and among its related pathways/superpathways are Allograft rejection and Aldosterone synthesis and secretion. The drugs tannic acid and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, pituitary and testes, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Disease Ontology : 12 A thyroid gland disease which involves an underproduction of thyroid hormone.

Wikipedia : 74 Hypothyroidism, also called underactive thyroid or low thyroid, is a disorder of the endocrine system in... more...

Related Diseases for Hypothyroidism

Diseases in the Hypothyroidism family:

Congenital Hypothyroidism Central Congenital Hypothyroidism
Hypothyroidism Due to Iodide Transport Defect Rare Adult Hypothyroidism
Transient Congenital Hypothyroidism Rare Hypothyroidism
Primary Congenital Hypothyroidism Hypothyroidism Due to Deficient Transcription Factors Involved in Pituitary Development or Function
Congenital Hypothyroidism Due to Maternal Intake of Antithyroid Drugs Transient Congenital Hypothyroidism Due to Maternal Factor
Transient Congenital Hypothyroidism Due to Neonatal Factor Congenital Hypothyroidism Due to Transplacental Passage of Tsh-Binding Inhibitory Antibodies
Congenital Hypothyroidism Due to Developmental Anomaly

Diseases related to Hypothyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1622)
# Related Disease Score Top Affiliating Genes
1 congenital hypothyroidism 35.7 TSHR TSHB TPO TG SLC5A5 SLC26A4
2 hypothyroidism, congenital, nongoitrous, 2 35.5 TSHR TPO TG SLC26A4 SERPINA7 PAX8
3 hypothyroidism, congenital, nongoitrous, 1 35.4 TSHR TG IYD
4 hypothyroidism, central, with testicular enlargement 35.4 TSHB TRH IGSF1
5 diabetes mellitus, neonatal, with congenital hypothyroidism 35.0 IYD GLIS3
6 primary congenital hypothyroidism 34.8 TSHR PAX8 NKX2-1
7 postsurgical hypothyroidism 34.8 TSHR TG
8 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 34.7 SLC26A4 IYD
9 iodine hypothyroidism 34.7 TSHR TPO TG
10 permanent congenital hypothyroidism 34.7 TPO DUOX2
11 transient congenital hypothyroidism 34.6 TSHR TPO DUOX2
12 pendred syndrome 34.4 TPO TG SLC26A4 PAX8 IYD DUOX2
13 hashimoto thyroiditis 34.3 TSHR TSHB TPO TG SLC26A4 RET
14 rare hypothyroidism 34.0 STAT1 RET GNB1 CHD7 ADNP
15 myxedema 34.0 TSHR TPO TG
16 familial thyroid dyshormonogenesis 33.9 TPO TG SLC5A5 IYD DUOX2
17 hyperthyroidism 33.8 TSHR TRH TPO TG SERPINA7
18 graves' disease 33.5 TSHR TPO TG SERPINA7 PAX8
19 subacute thyroiditis 33.3 TSHR TPO TG SERPINA7
20 thyroid crisis 33.3 TSHR TPO TG SERPINA7
21 athyreosis 32.9 TSHR TG SLC26A4 PAX8 NKX2-5 NKX2-1
22 thyroiditis 32.6 TSHR TSHB TRH TPO TG SERPINA7
23 goiter 32.6 TSHR TRH TPO TG SLC5A5 SLC26A4
24 thyroid ectopia 32.5 PAX8 NKX2-5
25 graves disease 1 32.3 TSHR TRH TPO TG SERPINA7
26 thyroid carcinoma 32.2 TSHR TPO TG RET NKX2-1
27 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 32.2 TSHR TPO TG
28 thyroid gland disease 32.0 TSHR TSHB TRH TPO TG SLC5A5
29 multinodular goiter 31.6 TSHR TPO TG SLC26A4 PAX8 NKX2-1
30 differentiated thyroid carcinoma 31.6 TSHR TPO TG RET PAX8 NKX2-1
31 endemic goiter 31.6 TSHR TSHB TPO TG SERPINA7 IYD
32 exophthalmos 31.5 TSHR TPO TG
33 nodular goiter 31.4 TSHR TPO TG SLC5A5 RET
34 euthyroid sick syndrome 31.3 TRH TG SERPINA7
35 hyperthyroxinemia 31.3 TSHR TRH TPO SERPINA7
36 thyroid hormone resistance, generalized, autosomal dominant 31.3 TSHR TSHB TRH TG SERPINA7
37 thyroid gland papillary carcinoma 31.3 TG RET PAX8 NKX2-1
38 papillary carcinoma 31.2 TSHR TPO TG RET PAX8 NKX2-1
39 plummer's disease 31.2 TSHR TPO TG
40 mechanical strabismus 31.2 TPO TG
41 dyshormonogenic goiter 31.0 TG SLC5A5 SLC26A4
42 turner syndrome 31.0 TPO TG SERPINA7
43 struma ovarii 30.9 TSHR TG RET NKX2-1
44 neonatal thyrotoxicosis 30.9 TSHR TG
45 papillary thyroid microcarcinoma 30.9 TSHR TG NKX2-1
46 thyroid malformation 30.8 SLC26A4 PAX8 NKX2-5 NKX2-1 IYD
47 acute thyroiditis 30.8 TPO TG IYD
48 toxic diffuse goiter 30.8 TSHR TPO TG SERPINA7
49 nontoxic goiter 30.8 TSHR TPO TG SERPINA7
50 hypothalamic disease 30.8 TSHB TRH

Comorbidity relations with Hypothyroidism via Phenotypic Disease Network (PDN): (show top 50) (show all 150)

Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Allergic Rhinitis Alzheimer Disease
Anxiety Aortic Valve Disease 1
Atypical Depressive Disorder Autonomic Nervous System Disease
Basilar Artery Insufficiency Benign Essential Hypertension
Bipolar Disorder Borderline Personality Disorder
Bronchiectasis Bronchitis
Bronchopneumonia Celiac Disease 1
Cerebral Atherosclerosis Cerebral Degeneration
Cerebrovascular Disease Chronic Pulmonary Heart Disease
Communicating Hydrocephalus Conjunctivitis
Conn's Syndrome Conversion Disorder
Cystitis Decubitus Ulcer
Deficiency Anemia Delusional Disorder
Dependent Personality Disorder Dermatomycosis
Diabetes Insipidus Diabetic Polyneuropathy
Dyshormonogenic Goiter Dyskinesia of Esophagus
Dysthymic Disorder Encephalopathy
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Esophagitis
Exophthalmos Familial Atrial Fibrillation
Female Breast Cancer Female Stress Incontinence
Femoral Vein Thrombophlebitis First-Degree Atrioventricular Block
Gastroesophageal Reflux Generalized Anxiety Disorder
Generalized Atherosclerosis Goiter

Graphical network of the top 20 diseases related to Hypothyroidism:

Diseases related to Hypothyroidism

Symptoms & Phenotypes for Hypothyroidism

MGI Mouse Phenotypes related to Hypothyroidism:

# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.31 CHD7 DUOX2 GLIS3 IGSF1 NKX2-1 NKX2-5
2 growth/size/body region MP:0005378 10.25 CHD7 DUOX2 GLIS3 IGSF1 NKX2-1 NKX2-5
3 behavior/neurological MP:0005386 10.22 CHD7 GNB1 NKX2-1 PAX8 RET SLC26A4
4 homeostasis/metabolism MP:0005376 10.2 CHD7 DUOX2 GLIS3 IGSF1 NKX2-1 NKX2-5
5 digestive/alimentary MP:0005381 10.06 CHD7 NKX2-1 NKX2-5 RET SLC26A4 STAT1
6 nervous system MP:0003631 10.06 ADNP CHD7 DUOX2 GNB1 IGSF1 NKX2-1
7 hearing/vestibular/ear MP:0005377 9.85 CHD7 DUOX2 PAX8 SLC26A4 TPO TSHR
8 limbs/digits/tail MP:0005371 9.8 CHD7 PAX8 RET STAT1 TG TPO
9 reproductive system MP:0005389 9.61 CHD7 DUOX2 IGSF1 NKX2-1 PAX8 RET
10 skeleton MP:0005390 9.36 CHD7 DUOX2 NKX2-1 PAX8 SLC26A4 SLC5A5

Drugs & Therapeutics for Hypothyroidism

Drugs for Hypothyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 602)
# Name Status Phase Clinical Trials Cas Number PubChem Id
tannic acid Approved Phase 4 1401-55-4
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
Nitroprusside Approved, Investigational Phase 4 15078-28-1 11963622
Nitric Oxide Approved Phase 4 10102-43-9 145068
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
Orlistat Approved, Investigational Phase 4 96829-58-2 3034010
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
Iron Approved, Experimental Phase 4 7439-89-6, 15438-31-0 23925 27284
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
Bexarotene Approved, Investigational Phase 4 153559-49-0 82146
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
Polyestradiol phosphate Approved Phase 4 28014-46-2
Leuprolide Approved, Investigational Phase 4 53714-56-0 3911 657181
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
Peginterferon alfa-2b Approved Phase 4 215647-85-1, 99210-65-8
Citalopram Approved Phase 4 59729-33-8 2771
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
Ribavirin Approved Phase 4 36791-04-5 37542
27 Orange Approved Phase 4
Fosphenytoin Approved, Investigational Phase 4 93390-81-9 56339
Levetiracetam Approved Phase 4 102767-28-2 441341
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
Colchicine Approved Phase 4 64-86-8 6167 2833
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
Bisoprolol Approved Phase 4 66722-44-9 2405
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
Norethindrone Approved Phase 4 68-22-4 6230
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
Acetaminophen Approved Phase 4 103-90-2 1983
Codeine Approved, Illicit Phase 4 76-57-3 5284371
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
44 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
Ethanol Approved Phase 4 64-17-5 702
Tranexamic Acid Approved Phase 4 1197-18-8 5526
Nimodipine Approved, Investigational Phase 4 66085-59-4 4497
Amiodarone Approved, Investigational Phase 4 1951-25-3 2157
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985

Interventional clinical trials:

(show top 50) (show all 1048)
# Name Status NCT ID Phase Drugs
1 Total Thyroidectomy With Harmonic Scalpel® Versus Standard Surgery. Open Multicentric Randomized Controlled Trial Unknown status NCT00385983 Phase 4
2 Beneficial Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism Unknown status NCT02316743 Phase 4 Levothyroxine supplementation
3 Randomized Crossover Trial for the Evaluation of the Possible Effects in the Intestine of Two Different Pharmaceutical Forms of L - Thyroxine in Patients With Primary Acquired Hypothyroidism Unknown status NCT02917863 Phase 4 L-Thyroxine (tablet, per os);L-Thyroxine (oral drops, solution)
4 Does Sodium Nitroprusside Infusion Affect Thyroidal Function in Patients Undergoing Coronary Artery Bypass Grafting, a Prospective Randomized Clinical Trial. Unknown status NCT00636584 Phase 4 sodium nitroprusside;placebo
5 What is the Optimal Serum TSH Concentration During Thyroxine Treatment for Primary Hypothyroidism? Effects of Fine Titration of Thyroxine Dosage on Wellbeing, Quality of Life and Cognitive Function Unknown status NCT00111735 Phase 4 Thyroxine
6 Effects of Thyroid Hormone Treatment on Mitochondrial Function, Ectopic Fat Accumulation, Insulin Sensitivity and Brown Adipose Tissue in Type 2 Diabetes Mellitus Unknown status NCT01379170 Phase 4 Euthyrox (levothyroxine)
7 Open-Label, Multi-Center, Randomized, Active-Controlled, Phase 4 Study of rAd-p53 Gene Mono-Therapy, With Concurrent Radioactive Iodine , or Combination With Surgery in Subjects With Advanced Malignant Thyroid Tumors Unknown status NCT00902122 Phase 4 rAd-p53 gene;p53 gene therapy
8 Efficacy of Dexmedetomidine for Cough Suppression During Anesthetic Emergence in Patients Undergoing Thyroid Surgery: A Randomized, Double Blinded, Controlled Trial Unknown status NCT03312413 Phase 4 Dexmedetomidine Hydrochloride;Normal Saline;Dexmedetomidine Hydrochloride;Dexmedetomidine Hydrochloride
9 Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General anesthesia---a Randomized Control Double-Blind Clinical Trial Unknown status NCT02613806 Phase 4 Dexmeditomidine;normal saline
10 An International, Randomised, Double-Blind, Two-Arm Study To Evaluate The Safety And Efficacy Of Vandetanib 150 And 300mg/Day In Patients With Unresectable Locally Advanced Or Metastatic Medullary Thyroid Carcinoma With Progressive Or Symptomatic Disease Unknown status NCT01496313 Phase 4 300mg vandetanib;150mg vandetanib
11 The Effect of Weight Loss With Orlistat or Sibutramine Administration , Hypocaloric Diet and Physical Exercise , on AMH Levels, in Women With Polycystic Ovary Syndrome Unknown status NCT01475019 Phase 4 Orlistat;Sibutramine
12 The Use of Lu177 in the Treatment of Progressive and Unresectable Metastatic Medullary Thyroid Cancer Unknown status NCT01915485 Phase 4
13 Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease Unknown status NCT02339142 Phase 4 intravenous corticosteroids (methylprednisolone)
14 Maintenance of Vitamin D Sufficiency With Oral Vitamin D Supplementation in Malaysian Women of Malay and Indian Ethnicity With Post Menopausal Osteoporosis Unknown status NCT02389179 Phase 4 Vitamin D3
15 The Monitor of Serum Prolactin Level and Related Clinical Observations Among Individuals With Schizophrenia Spectrum Illnesses in a 3 Months Aripiprazole Trial Unknown status NCT00468533 Phase 4 Aripiprazole
16 Effect of Thyroid Hormone Replacement on Fatigability in Untreated Older Adults With Subclinical Hypothyroidism Completed NCT02500342 Phase 4 Levothyroxine;Placebo
17 Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction: a Prospective Evaluation and Impact of Treatment Completed NCT02491008 Phase 4 Levothyroxine;Placebo
18 Neurocognitive and Metabolic Effects of Mild Hypothyroidism Completed NCT00565864 Phase 4 L-thyroxine (L-T4)
19 Impact of Thyroid Hormone Replacement on Cardiac Function: a Randomized Placebo-Controlled Trial in Older Adults With Subclinical Hypothyroidism Completed NCT02832960 Phase 4 Levothyroxine;Placebo
20 Impact of Thyroid Hormone Replacement on Progression of Atherosclerosis : a Randomized Placebo-Controlled Trial in Older Adults With Subclinical Hypothyroidism. Completed NCT02832934 Phase 4 Levothyroxine;Placebo
21 Estimation of Carbohydrate Metabolism Disorder Frequency in Hypertriglyceridemia Induced by Bexarotene Treatment of Cutaneous T Cell Lymphoma - Pilote Study Completed NCT01569724 Phase 4
22 A Dosimetry Study of Radioiodine (131-I) Uptake Following the Administration of Thyrogen and Hypothyroid States During Thyroid Hormone Withdrawal Completed NCT00001730 Phase 4 Thyrogen
23 Effect of T4-T3 Combination Therapy Versus T4 Monotherapy in Patients With Hypothyroidism,a Double Blind Randomized Cross-Over Study. Completed NCT00531713 Phase 4 Triiodothyronine
24 Concomitant Use of Growth Hormone and GnRH Agonist in Adolescent Patients With Acquired Hypothyroidism Completed NCT00206375 Phase 4 Growth hormone;Growth hormone treatment and puberty
25 A Randomised, Controlled, Crossover Study: Treatment With Thyroxin Compared to Thyroxin + Triiodothyronin in Patients With Secondary Hypothyroidism Completed NCT00360074 Phase 4 Thyroxin, Triiodothyronine
26 Single-center, Randomized, Double-Blinded, Comparative Study of the Effectiveness of L-carnitine in Patients'Fatigue Degree Changing With Hypothyroidism Who Take Levothyroxine Completed NCT01769157 Phase 4 L-carnitine;Placebo
27 Assessing Quality of Life Changes Using Calcitonin in Patients With Hypothyroidism on Biochemical Replacement With Levothyroxine Completed NCT03342001 Phase 4 Calcitonin
28 SWITCH OR ADD PEGYLATED-INTERFERON IN CHRONIC HEPATITIS B PATIENTS ON LONG TERM NUCLEOS(T)IDE THERAPY (SWAP TRIAL) Completed NCT01928511 Phase 4 peg-interferon alpha 2b, 1.5mcg/kg s/c given weekly;Nucleos(t)ide analogue therapy
29 A Double-masked, Methylprednisolone-control, Efficacy and Safety Study of 99Tc-MDP for Thyroid Associated Ophthalmopathy. Completed NCT03948191 Phase 4 Methylprednisolone;99Tc-MDP(99Technetium-Methylenediphosphonate Injection)
30 A Single-center Interventional Study to Verify Clinical Utility of the Quantitative and the Qualitative POC TSH Test Kits Compared With the Third Generation TSH Test Kit Completed NCT01921452 Phase 4
31 Study of Optimal Replacement of Thyroxine in the Elderly (SORTED) SORTED 1 - a Randomised Controlled Trial (Pilot Study), SORTED 2 - Qualitative Interviews, SORTED 3 - Retrospective Cohort Completed NCT01647750 Phase 4 Levothyroxine;Levothyroxine
32 Thyroid Hormone Replacement for Subclinical Hypothyroidism (TRUST) - Subanalysis on Subclinical Hypothyroidism and Depression Completed NCT01853579 Phase 4 Levothyroxine;Placebo
33 Multi-modal Effects of Thyroid Hormone Replacement for Untreated Older Adults With Subclinical Hypothyroidism; a Randomised Placebo-controlled Trial Completed NCT01660126 Phase 4 Levothyroxine;Placebo
34 Is the Routine Pressure Dressing After Thyroidectomy Necessary? A Prospective Randomized Controlled Study Completed NCT00400465 Phase 4
35 Bioequivalence of Two Levothyroxine Tablet Formulations in Healthy Indian Volunteers: A Single-dose, Randomized, Open-label, Crossover Study Completed NCT01536678 Phase 4 Levothyroxine;Levothyroxine
36 Efficiency and Safety Study of Short-term Prednisone to Treat Moderate and Severe Subacute Thyroiditis Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
37 Is it Possible to Increase Quality of Life, Using Recombinant TSH Instead of Withdrawal of Thyroid Hormone Treatment, Before Iodine Uptake in Patients With Thyroid Cancer? Completed NCT00604318 Phase 4 rhTSH
38 Iodine Intake & Status of Preschoolers Given Micronutrient Powder for 6 Months Completed NCT02280330 Phase 4
39 Multicentric Randomized Controlled Study of Percutaneous Laser Ablation Versus Follow Up in Benign Thyroid Nodules. Long Term Results Completed NCT00858104 Phase 4
40 Response to Peg-interferon and Ribavirin for the Treatment of HCV Infection in HIV Co-infected Patients, Implemented in Public Hospitals in Thailand Completed NCT02247440 Phase 4 Peg-interferon + ribavirin under HIV physician supervision
41 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
42 Safety Profile of Iodopovidone as an Agent for Pleurodesis in Malignant Pleural Effusion Completed NCT01670786 Phase 4
43 Safety and Efficacy of Oral Mega Pulse Methylprednisolone in Severe Therapy Resistant Alopecia Areata Completed NCT01167946 Phase 4 methylprednisolone sodium succinate;methylprednisolone sodium succinate;methylprednisolone sodium succinate
44 IV Keppra in the Emergency Department for Prevention of Early Recurrent Seizures Completed NCT00510783 Phase 4 Keppra;Fosphenytoin;Dilantin
45 Levosimendan Efficacy Assessment by Cardiopulmonary Exercise Test (CPET) Completed NCT02261948 Phase 4 Levosimendan;Placebo
46 The Comparison of the Efficacy of Once and Twice Daily Colchicine Dosage in Pediatric Patients With Familial Mediterranean Fever: A Randomized Trial Completed NCT02602028 Phase 4 colchicine
47 Improving Multivitamin Supplementation to Pregnant Women Completed NCT02300155 Phase 4 Pregvit®;Orifer F®
48 Bisoprolol Versus Corticosteroid and Bisoprolol Combination for Prophylaxis Against Atrial Fibrillation After on Pump Coronary Artery Bypass Surgery Completed NCT03800264 Phase 4 Bisoprolol
49 Long Term Efficacy and Tolerability of a Nutraceutical Combination (Red Yeast Rice, Policosanols and Berberine) in Low-moderate Risk Hypercholesterolemic Patients: a Double-blind, Placebo Controlled Study Completed NCT02078167 Phase 4
50 Risperidone Augmentation for Treatment-Resistant Aggression in ADHD Completed NCT00297739 Phase 4 Risperidone

Search NIH Clinical Center for Hypothyroidism

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Kelp preparation

Cochrane evidence based reviews: hypothyroidism

Genetic Tests for Hypothyroidism

Genetic tests related to Hypothyroidism:

# Genetic test Affiliating Genes
1 Hypothyroidism 29

Anatomical Context for Hypothyroidism

MalaCards organs/tissues related to Hypothyroidism:

Thyroid, Pituitary, Testes, Heart, Brain, Liver, Bone

Publications for Hypothyroidism

Articles related to Hypothyroidism:

(show top 50) (show all 34029)
# Title Authors PMID Year
Thyroid replacement therapy, thyroid stimulating hormone concentrations, and long term health outcomes in patients with hypothyroidism: longitudinal study. 61 42
31481394 2019
Subclinical Hypothyroidism. 61 42
31287524 2019
Thyroid diseases increased the risk of type 2 diabetes mellitus: A nation-wide cohort study. 61 42
31096476 2019
Extracorporeal membrane oxygenation for the anesthetic management of a patient with a massive intrathoracic goiter causing severe tracheal obstruction with positional symptoms: A case report. 42
31626151 2019
Impact of ultrasound angiography combined with fine needle aspiration for the diagnosis of thyroid nodules. 42
31574847 2019
Impact of ultrasound-guided fine needle aspiration cytology for diagnosis of thyroid nodules. 42
31567964 2019
Genetics and phenomics of hypothyroidism and goiter due to TPO mutations. 54 61
20153806 2010
Genetics and phenomics of hypothyroidism and goiter due to NIS mutations. 54 61
20153805 2010
Genetics and phenomics of hypothyroidism and goiter due to thyroglobulin mutations. 54 61
20093166 2010
Congenital hypothyroidism in a kitten resulting in decreased IGF-I concentration and abnormal liver function tests. 54 61
20223692 2010
Runx2 deficiency in mice causes decreased thyroglobulin expression and hypothyroidism. 54 61
20375239 2010
Genetics and phenomics of hypothyroidism and thyroid dys- and agenesis due to PAX8 and TTF1 mutations. 54 61
20302910 2010
Four patients with hypothyroid Graves' disease. 54 61
20421660 2010
Dual oxidase, hydrogen peroxide and thyroid diseases. 54 61
20407074 2010
Biallelic p.R2223H mutation in the thyroglobulin gene causes thyroglobulin retention and severe hypothyroidism with subsequent development of thyroid carcinoma. 54 61
20089614 2010
Turner syndrome and schizophrenia: a further hint for the role of the X-chromosome in the pathogenesis of schizophrenic disorders. 54 61
20218787 2010
Molecular analysis of congenital goitres with hypothyroidism caused by defective thyroglobulin synthesis. Identification of a novel c.7006C>T [p.R2317X] mutation and expression of minigenes containing nonsense mutations in exon 7. 54 61
19438905 2010
Broad clinical involvement in a family affected by the fragile X premutation. 54 61
19996900 2009
Diagnosis and discrimination of autoimmune Graves' disease and Hashimoto's disease using thyroid-stimulating hormone receptor-containing recombinant proteoliposomes. 54 61
19914592 2009
Environmental pollutants and the thyroid. 54 61
19942155 2009
Thyrotropin-stimulating hormone receptor gene analysis in pediatric patients with non-autoimmune subclinical hypothyroidism. 54 61
19820021 2009
Congenital leptin deficiency and thyroid function. 54 61
19889232 2009
GH replacement in adults: interactions with other pituitary hormone deficiencies and replacement therapies. 54 61
19684055 2009
[Clinical significance of apolipoprotein B-48 (apoB-48) in patients with thyroid disease]. 54 61
20030174 2009
Panhypopituitarism due to metastases to the hypothalamus and the pituitary resulting from primary breast cancer: a case report and review of the literature. 54 61
19933072 2009
More hypothyroidism and less hyperthyroidism with sufficient iodine nutrition compared to mild iodine deficiency--a comparative population-based study of older people. 54 61
19762181 2009
Subclinical hypothyroidism and autoimmune thyroiditis in pregnancy--a study in south Indian subjects. 54 61
20329425 2009
Radioiodine ablation: when and how. 54 61
19910900 2009
Final diagnosis in children with subclinical hypothyroidism and mutation analysis of the thyroid peroxidase gene (TPO). 54 61
19960894 2009
The p.A2215D thyroglobulin gene mutation leads to deficient synthesis and secretion of the mutated protein and congenital hypothyroidism with wide phenotype variation. 54 61
19509106 2009
Ovarian hyper-stimulation syndrome after spontaneous conception. 54 61
19499413 2009
[Sarcoidosis associated with hypothyroidism due to thyrotropin-receptor blocking antibodies]. 54 61
18930567 2009
Persistent hyperprolactinemia following mammoplasty: a rare association. 54 61
19634649 2009
Subclinical hypothyroidism in children and adolescents: a wide range of clinical, biochemical, and genetic factors involved. 54 61
19417038 2009
TSH receptor - autoantibody interactions. 54 61
19530271 2009
Effects of thyroxine replacement on serum creatinine and cystatin C in patients with primary and central hypothyroidism. 54 61
19529992 2009
Growth hormone/insulin-like growth factor axis in patients with subclinical thyroid dysfunction. 54 61
19111490 2009
Type 2 iodothyronine deiodinase in skeletal muscle: effects of hypothyroidism and fasting. 54 61
19293265 2009
Persistence of goitre in children post-salt iodization in Islamic Republic of Iran: autoimmune status. 54 61
19731774 2009
Serum leptin in overt and subclinical hypothyroidism: effect of levothyroxine treatment and relationship to menopausal status and body composition. 54 61
19415994 2009
[Sodium-iodine symporter in thyroid, normal and cancer tissues and its relation to nuclear medicine and to gene cloning treatment]. 54 61
19675882 2009
Mainly the younger hypothyroid patients are referred to hospital--evidence for referral bias. 54 61
18945587 2009
Evolution of sonographic appearance of the thyroid gland in children with Hashimoto's thyroiditis. 54 61
19554808 2009
Influence of iodide excess and interferon-gamma on human primary thyroid cell proliferation, thyroglobulin secretion, and intracellular adhesion molecule-1 and human leukocyte antigen-DR expression. 54 61
19265500 2009
Thyroid function and changes in ultrasound morphology during antiviral therapy with pegylated interferon and ribavirin in patients with chronic hepatitis C. 54 61
19175874 2009
Non-functioning pituitary adenomas: clinical feature, laboratorial and imaging assessment, therapeutic management and outcome. 54 61
19347183 2009
An inactivating mutation within the first extracellular loop of the thyrotropin receptor impedes normal posttranslational maturation of the extracellular domain. 54 61
18927215 2009
Functional studies of new TSH receptor (TSHr) mutations identified in patients affected by hypothyroidism or isolated hyperthyrotrophinaemia. 54 61
18727713 2009
Involvement of CRH-R2 receptor in eating behavior and in the response of the HPT axis in rats subjected to dehydration-induced anorexia. 54 61
18951722 2009
Increased thrombin-activatable fibrinolysis inhibitor and decreased tissue factor pathway inhibitor in patients with hypothyroidism. 54 61
18958631 2009