Hypotrichosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HYP087 MIFTS: 48	Hypotrichosis Categories: Genetic diseases, Rare diseases
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Aliases & Classifications for Hypotrichosis

MalaCards integrated aliases for Hypotrichosis:

Name: Hypotrichosis ¹² ⁷⁶ ²⁹ ⁴⁴ ¹⁵

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4535

MeSH ⁴⁴ D007039

NCIt ⁵⁰ C34720

SNOMED-CT ⁶⁸ 53602002 56558005

UMLS ⁷³ C0020678

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Summaries for Hypotrichosis

Disease Ontology : ¹² A hair disease that is characterized by sparse hair on the scalp resulting from abnormal hair follicle development and has_material_basis in mutations in proteins involved in hair growth, division or proliferation of cells within hair follicles.

MalaCards based summary : Hypotrichosis is related to hypotrichosis 6 and hypotrichosis 7. An important gene associated with Hypotrichosis is MUHH2 (Hypotrichosis, Hereditary, Marie Unna Type, 2), and among its related pathways/superpathways are Developmental Biology and Keratinization. The drugs Minoxidil and Clobetasol have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and testes, and related phenotype is integument.

Wikipedia : ⁷⁶ Hair loss, also known as alopecia or baldness, refers to a loss of hair from part of the head or body.... more...

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Related Diseases for Hypotrichosis

Diseases in the Hypotrichosis family:

Hypotrichosis 2	Hypotrichosis 4
Hypotrichosis 8	Hypotrichosis 7
Hypotrichosis 1	Hypotrichosis 6
Hypotrichosis 5	Hypotrichosis 3
Hypotrichosis 9	Hypotrichosis 10
Hypotrichosis 11	Hypotrichosis 12
Hypotrichosis 13

Diseases related to Hypotrichosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)

#	Related Disease	Score	Top Affiliating Genes
1	hypotrichosis 6	34.6	DSG4 KRT74 LIPH LPAR6
2	hypotrichosis 7	34.4	DSG4 KRT25 KRT74 LIPH LPAR6
3	hypotrichosis 13	34.2	KRT25 KRT71 KRT74 LIPH
4	hypotrichosis simplex of the scalp	34.2	CDSN KRT74
5	hypotrichosis 8	34.1	DSG4 KRT25 KRT74 LIPH LPAR6
6	hypotrichosis simplex	33.7	APCDD1 CDSN DSG4 LIPH LPAR6 RPL21
7	monilethrix	32.9	DSG4 KRT74 LPAR6
8	woolly hair syndrome	32.4	KRT25 KRT71 KRT74 LIPH LPAR6
9	ectodermal dysplasia 4, hair/nail type	32.0	HOXC13 KRT74
10	ectodermal dysplasia	30.7	CDH3 HOXC13 KRT74
11	pemphigus vulgaris	30.5	DSC3 DSG1 DSG4
12	pemphigus	30.4	DSC3 DSG1 DSG4
13	skin disease	29.9	CDSN DSC3 DSG1 DSG4 GJA1
14	hypotrichosis 2	12.4
15	hypotrichosis, congenital, with juvenile macular dystrophy	12.3
16	hypotrichosis 1	12.3
17	hypotrichosis-lymphedema-telangiectasia syndrome	12.3
18	hypotrichosis 4	12.3
19	hypotrichosis 3	12.3
20	hypotrichosis and recurrent skin vesicles	12.2
21	marie unna congenital hypotrichosis	12.2
22	short stature, onychodysplasia, facial dysmorphism, and hypotrichosis	12.2
23	hypotrichosis 11	12.2
24	hypotrichosis 12	12.2
25	erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper-ige	12.1
26	hypotrichosis 5	12.1
27	hypotrichosis-lymphedema-telangiectasia-renal defect syndrome	12.1
28	metaphyseal dysplasia without hypotrichosis	12.1
29	hypotrichosis 9	12.1
30	hypotrichosis 10	12.1
31	ichthyosis, congenital, autosomal recessive 11	12.0
32	hypotrichosis-osteolysis-periodontitis-palmoplantar keratoderma syndrome	11.9
33	juvenile macular degeneration and hypotrichosis	11.9
34	woolly hair, hypotrichosis, everted lower lip, and outstanding ears	11.9
35	hypotrichosis-deafness syndrome	11.9
36	spondyloepimetaphyseal dysplasia with hypotrichosis	11.8
37	brachymetapody-anodontia-hypotrichosis-albinoidism	11.8
38	leukomelanoderma, infantilism, mental retardation, hypodontia, hypotrichosis	11.8
39	hypotrichosis, progressive patterned scalp, with wiry hair, onycholysis, and cleft lip/palate	11.8
40	hypotrichosis of eyelid	11.7
41	congenital hypotrichosis milia	11.7
42	leukomelanoderma mental redardation hypotrichosis	11.7
43	hypotrichosis-intellectual disability, lopes type	11.7
44	bazex syndrome	11.7
45	schopf-schulz-passarge syndrome	11.6
46	palmoplantar keratoderma and congenital alopecia 1	11.6
47	rombo syndrome	11.5
48	ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis	11.5
49	woolly hair, autosomal recessive 3	11.4
50	hallermann-streiff syndrome	11.2

Graphical network of the top 20 diseases related to Hypotrichosis:

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Symptoms & Phenotypes for Hypotrichosis

MGI Mouse Phenotypes related to Hypotrichosis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument	MP:0010771	9.36	SOX18 CDH3 DSC3 DSG1 DSG4 GJA1

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Drugs & Therapeutics for Hypotrichosis

Drugs for Hypotrichosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 235)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Minoxidil

Approved, Investigational

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

38304-91-5

4201

Clobetasol

Approved, Investigational

Phase 4,Phase 3

25122-46-7, 25122-41-2

32798 5311051

Finasteride

Approved

Phase 4,Phase 3,Phase 1,Phase 2

98319-26-7

57363

Triamcinolone

Approved, Vet_approved

Phase 4,Phase 2,Not Applicable

124-94-7

31307

Prednisolone

Approved, Vet_approved

Phase 4,Not Applicable

50-24-8

5755

Methylprednisolone

Approved, Vet_approved

Phase 4,Not Applicable

83-43-2

6741

Spironolactone

Approved

Phase 4,Phase 2

1952-01-7, 52-01-7

5833

Hydroxychloroquine

Approved

Phase 4

118-42-3

3652

Capsaicin

Approved

Phase 4,Not Applicable

404-86-4

1548943

Imiquimod

Approved, Investigational

Phase 4

99011-02-6

57469

Betamethasone

Approved, Vet_approved

Phase 4

378-44-9

9782

Latanoprost

Approved, Investigational

Phase 4,Not Applicable

130209-82-4

5282380 5311221

Bimatoprost

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

155206-00-1

5311027

Apremilast

Approved, Investigational

Phase 4,Not Applicable

608141-41-9

11561674

Orange

Approved, Nutraceutical

Phase 4,Not Applicable

triamcinolone acetonide

Phase 4,Phase 2,Not Applicable

Prednisolone acetate

Phase 4,Not Applicable

Analgesics

Phase 4,Phase 1,Phase 2,Early Phase 1,Not Applicable

glucocorticoids

Phase 4,Phase 3,Phase 2,Not Applicable

5-alpha Reductase Inhibitors

Phase 4,Phase 3,Phase 1,Phase 2

Respiratory System Agents

Phase 4,Phase 1,Phase 2

Methylprednisolone acetate

Phase 4,Not Applicable

Methylprednisolone Hemisuccinate

Phase 4,Not Applicable

Adjuvants, Immunologic

Phase 4,Phase 2,Not Applicable

Gastrointestinal Agents

Phase 4,Not Applicable

Neuroprotective Agents

Phase 4,Phase 2,Not Applicable

Steroid Synthesis Inhibitors

Phase 4,Phase 3,Phase 1,Phase 2

Analgesics, Non-Narcotic

Phase 4,Phase 1,Phase 2,Not Applicable

Hormone Antagonists

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Dermatologic Agents

Phase 4,Phase 3,Not Applicable

Triamcinolone diacetate

Phase 4,Phase 2,Not Applicable

Triamcinolone hexacetonide

Phase 4,Phase 2,Not Applicable

Hormones

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Anti-Anxiety Agents

Phase 4,Early Phase 1

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Vasodilator Agents

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Anti-Asthmatic Agents

Phase 4,Phase 1,Phase 2

Emollients

Phase 4

Peripheral Nervous System Agents

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

Anti-Bacterial Agents

Phase 4,Not Applicable

Hypnotics and Sedatives

Phase 4

Pharmaceutical Solutions

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Antihypertensive Agents

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Immunosuppressive Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Prednisolone hemisuccinate

Phase 4,Not Applicable

Prednisolone phosphate

Phase 4,Not Applicable

Anti-Infective Agents

Phase 4,Phase 2,Not Applicable

Antiemetics

Phase 4,Not Applicable

Protective Agents

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Anti-Inflammatory Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 241)

#	Name	Status	NCT ID	Phase	Drugs
1	Acupuncture for Sedation in the Intensive Care Unit (ICU)	Unknown status	NCT01362270	Phase 4
2	Safety and Efficacy of Clobetasol Propionate 0.05% E Foam in Alopecia	Unknown status	NCT01111981	Phase 4	Clobetasol Propionate 0.05% Emollient Foam
3	Latisse (Bimatoprost .03% Opthalmic Solution) for the Treatment of Hypotrichosis of the Eyebrows: Latisse Versus Placebo	Completed	NCT01387906	Phase 4	topical bimatoprost
4	Study of Bimatoprost Solution in Increasing Eyelash Prominence in African Americans With Eyelash Hypotrichosis	Completed	NCT00958035	Phase 4	bimatoprost ophthalmic 0.03% solution;vehicle sterile solution (placebo)
5	Safety and Efficacy of Bimatoprost 0.03% Solution for the Treatment of Thinning Eyebrows	Completed	NCT01891487	Phase 4	Track A;Track B
6	Safety and Efficacy of Bimatoprost Solution in Treating Eyelash Loss or Hypotrichosis in Children	Completed	NCT01023841	Phase 4	bimatoprost ophthalmic solution 0.03%;Vehicle Sterile Solution
7	Study Assessing Patient Satisfaction With LATISSE® for Increasing Eyelash Prominence	Completed	NCT01448525	Phase 4	bimatoprost ophthalmic solution 0.03%;bimatoprost vehicle solution
8	Safety and Efficacy of LATISSE® in the Augmentation of Eyelashes of Korean Subjects	Completed	NCT01229423	Phase 4	bimatoprost 0.03%
9	Minoxidil 2% for Eyebrow Enhancement	Completed	NCT01672307	Phase 4	Minoxidil lotion 2%;Placebo
10	Minoxidil 1% for Eyebrow Enhancement	Completed	NCT01924000	Phase 4	Minoxidil lotion 1%;Placebo
11	Topical 5% Minoxidil and Potent Topical Corticosteroid Versus Intralesional Corticosteroid in the Treatment of Alopecia Areata	Completed	NCT03535233	Phase 4	Triamcinolone Acetonide;Minoxidil 5 % Topical Spray;clobetasol propionate
12	Comparison of Topical Latanoprost vs Topical Corticosteroid in Treatment of Localized Alopecia Areata	Completed	NCT02350023	Phase 4	Topical latanoprost 0.005%;Topical betamethasone 0.05%
13	Safety and Efficacy of Oral Mega Pulse Methylprednisolone in Severe Therapy Resistant Alopecia Areata	Completed	NCT01167946	Phase 4	methylprednisolone sodium succinate;methylprednisolone sodium succinate;methylprednisolone sodium succinate
14	Aldara for the Treatment of Extensive Alopecia Areata	Completed	NCT00177021	Phase 4	Aldara Cream 5%
15	Plaquenil for Alopecia Areata, Alopecia Totalis	Completed	NCT00176982	Phase 4	Hydroxychloroquine
16	Response of Topical Capsaicin in Alopecia Areata	Completed	NCT00176969	Phase 4	Capsaicin
17	Characteristics of T Cells From Alopecia Areata Scalp Skin Before and After Treatment With Aldara 5%	Completed	NCT00176943	Phase 4	Aldara Cream 5%
18	Apremilast in the Treatment of Central Centrifugal Cicatricial Alopecia (CCCA)	Recruiting	NCT03521687	Phase 4	Apremilast
19	Adipose Derived Stem Cells Versus Platelet Rich Plasma on Follicular Unit Extraction	Recruiting	NCT03388840	Phase 4
20	Intralesional Steroids in the Treatment of Alopecia Areata	Recruiting	NCT01898806	Phase 4	Intralesional Triamcinolone 2.5 mg/ml;Intralesional Triamcinolone 5 mg/ml;Intralesional Triamcinolone 10 mg/ml;Intralesional Saline
21	Comparing Different Platelet Rich Plasma (PRP) Treatment Regimens for Management of Androgenic Alopecia	Active, not recruiting	NCT02999737	Phase 4
22	Cryotherapy Versus Steroids In Alopecia Areata:Trichoscopic Evaluation	Not yet recruiting	NCT03473600	Phase 4	Triamcinolone acetonide injection
23	Trial Evaluating the Efficacy of Apremilast for the Treatment of Frontal Fibrosing Alopecia	Not yet recruiting	NCT03422640	Phase 4	Apremilast
24	The Use of 5mg Finasteride Versus 200mg Spironolactone and Topical 5% Minoxidil in Treating Postmenopausal Female Androgenetic Alopecia	Withdrawn	NCT02483195	Phase 4	5% Minoxidil;200mg Spironolactone;5mg Finasteride
25	Efficacy and Safety of Mesotherapy With Minoxidil 0.5%/2ml for Androgenetic Alopecia in Female Patients	Unknown status	NCT01655108	Phase 3	Minoxidil;Saline
26	Safety and Efficacy Study of Bimatoprost in Japanese Patients With Eyelash Hypotrichosis	Completed	NCT01391273	Phase 3	bimatoprost solution 0.03%;bimatoprost vehicle solution
27	Safety and Efficacy Study of Bimatoprost in Japanese Patients With Chemotherapy-Induced Eyelash Hypotrichosis	Completed	NCT01391286	Phase 3	bimatoprost solution 0.03%;bimatoprost vehicle solution
28	Bimatoprost for the Treatment of Eyebrow Hypotrichosis	Completed	NCT01765764	Phase 3	bimatoprost solution;Vehicle to bimatoprost solution
29	Bimatoprost in the Treatment of Eyelash Hypotrichosis	Completed	NCT01698554	Phase 3	bimatoprost formulation A solution;bimatoprost solution 0.03 %;vehicle of bimatoprost formulation A solution;vehicle of bimatoprost solution 0.03 %
30	Safety and Efficacy Study of Bimatoprost to Treat Hypotrichosis of the Eyelashes After Application to the Eyelid Margin	Completed	NCT00907426	Phase 3	Bimatoprost 0.03% solution;Vehicle solution
31	Study of Bimatoprost Gel on Eyelash Growth	Completed	NCT01200251	Phase 3	Bimatoprost eyelash gel
32	Study to Evaluate the Efficacy and Safety of P-3074 Topical Solution in the Treatment of Androgenetic Alopecia	Completed	NCT03004469	Phase 3	P-3074;Finasteride;Vehicle
33	The Efficiency Of The Methotrexate At Patients Affected By Grave Pelade	Completed	NCT02037191	Phase 3	Methotrexate;Placebo
34	Sexual Function in Men Receiving Dutasteride for Androgenetic Alopecia	Completed	NCT02014584	Phase 3	Dutasteride;Placebo
35	A Long-term Study to Determine Safety and Efficacy of Dutasteride in Male Subjects With Androgenetic Alopecia	Completed	NCT01831791	Phase 3	Dutasteride 0.5 mg
36	Enhancing Hair Density With Platelet Rich Fibrin Matrix (PRFM)	Completed	NCT01590238	Phase 3
37	A Trial of Clobetasol Propionate Versus Hydrocortisone in Children With Alopecia Areata	Completed	NCT01453686	Phase 3	Hydrocortisone 1%;Clobetasol Propionate 0.05%
38	Efficacy Study of Minoxidil Lotion Versus Combined Minoxidil and Finasteride Lotion to Treat Male Pattern Hair Loss	Completed	NCT01391156	Phase 3	3%Minoxidil lotion;3% Minoxidil with 0.1% Finasteride lotion
39	Dutasteride Versus Placebo and Finasteride in Men With Androgenetic Alopecia	Completed	NCT01231607	Phase 3	1mg Finasteride active;0.02mg dutasteride;0.1mg dutasteride;0.5mg dutasteride;Finasteride placebo;Dutasteride placebo
40	Clinical Trial in Females for Female Pattern Hair Loss	Completed	NCT01226459	Phase 3	5% Minoxidil Topical Foam;Vehicle Topical Foam
41	Clinical Trial in Females With Female Pattern Hair Loss	Completed	NCT01145625	Phase 3	5% Minoxidil;2% Minoxidil
42	The Randomized Double-blind Placebo-controlled Trial of Intralesional Botulinum Toxin A Injection for Recalcitrant Alopecia Totalis and Alopecia Universalis	Completed	NCT00997815	Phase 2, Phase 3	Botulinum toxin A;Normal saline injection
43	Efficacy and Safety Study to Compare Two Minoxidil Formulations on Women With Androgenetic Alopecia	Completed	NCT00958750	Phase 3	minoxidil
44	A Study To Assess The Efficacy And Safety Of Dutasteride 0.5mg Once Daily For 6 Months In The Treatment Of Male Subjects With Androgenetic Alopecia	Completed	NCT00441116	Phase 3	Dutasteride 0.5mg oral tablets
45	Effects of Finasteride on Serum Prostate-Specific Antigen (0906-111)	Completed	NCT00396175	Phase 3	MK0906, finasteride / Duration of Treatment : 48 Weeks;Comparator : placebo (unspecified) / Duration of Treatment : 48 Weeks
46	A Study to Evaluate the Effectiveness and Safety of 5 Percent Minoxidil Foam in the Treatment of Male Pattern Hair Loss	Completed	NCT00151515	Phase 3	minoxidil
47	Phase II Randomized Bilateral Comparison of Topical Targretin Gel 1% in Alopecia Areata	Completed	NCT00063076	Phase 2, Phase 3	Targretin Gel 1%
48	Efficacy and Safety of LH-8 in Paediatric Alopecia Areata	Recruiting	NCT03240627	Phase 2, Phase 3	LH-8;Placebos
49	TREg Activation in the Treatment of the PELADE (Alopecia Areata)	Active, not recruiting	NCT02557074	Phase 3	IL2;placebo
50	A Study of Baricitinib (LY3009104) in Participants With Severe or Very Severe Alopecia Areata	Not yet recruiting	NCT03570749	Phase 2, Phase 3	Baricitinib;Placebo

Search NIH Clinical Center for Hypotrichosis

Cochrane evidence based reviews: hypotrichosis

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Genetic Tests for Hypotrichosis

Genetic tests related to Hypotrichosis:

#	Genetic test	Affiliating Genes
1	Hypotrichosis ²⁹

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Anatomical Context for Hypotrichosis

MalaCards organs/tissues related to Hypotrichosis:

⁴¹

Skin, Brain, Testes, Bone, T Cells, Prostate, Ovary

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Publications for Hypotrichosis

Articles related to Hypotrichosis:

(show top 50) (show all 309)

#	Title	Authors	Year
1	Further delineation of the SOX18-related Hypotrichosis, Lymphedema, Telangiectasia syndrome (HTLS). ( 29307792 )	Valenzuela I....Tizzano E.	2018
2	Therapeutic potential of bimatoprost for the treatment of eyebrow hypotrichosis. ( 29503529 )	Chanasumon N....Suchonwanit P.	2018
3	A novel insertion mutation of CDSN responsible for hypotrichosis simplex of scalp in a Chinese family. ( 29797736 )	Huang H....Zhang X.	2018
4	Clinical course of the first Japanese family with Marie Unna hereditary hypotrichosis: a follow-up report. ( 29952295 )	Masuda Y....Tokura Y.	2018
5	Novel splice site mutation in the LIPH gene in a patient with autosomal recessive woolly hair/hypotrichosis: Case report and published work review. ( 29464811 )	Mizukami Y....Sugawara K.	2018
6	A disease-causing novel missense mutation in the ST14 gene underlies autosomal recessive ichthyosis with hypotrichosis syndrome in a consanguineous family. ( 29611532 )	Ahmad F....Ahmad W.	2018
7	Hypotrichosis in a Child with Olmsted Syndrome. ( 29441307 )	Polly D....Karthikeyan K.	2018
8	Congenital Hypotrichosis and Congenital Atrichia. ( 29551108 )	Al-Dawsari N.A....Kaliyadan F.	2018
9	Novel CLDN1 mutation in ichthyosis-hypotrichosis-sclerosing-cholangitis syndrome without signs of liver disease. ( 28906553 )	Nagtzaam I.F....van Steensel M.A.M.	2017
10	Novel heterozygous mutation, c.74C&gt;G (p.Pro25Arg), in the U2HR gene underlies Marie Unna hereditary hypotrichosis in a Japanese family. ( 28406533 )	Yoshida K....Niizeki H.	2017
11	A novel mutation in ST14 at a functionally significant amino acid residue expands the spectrum of ichthyosis-hypotrichosis syndrome. ( 29208051 )	Youssefian L....Uitto J.	2017
12	Novel mutations in the lipase H gene lead to secretion defects of LIPH in Chinese patients with autosomal recessive woolly hair/hypotrichosis (ARWH/HT). ( 29346610 )	Chang X.D....Song Q.H.	2017
13	A Missense Mutation within the Helix Termination Motif of KRT25 Causes Autosomal Dominant Woolly Hair/Hypotrichosis. ( 28899683 )	Yu X....Li M.	2017
14	New CDH3 mutation in the first Spanish case of hypotrichosis with juvenile macular dystrophy, a case report. ( 28061825 )	Blanco-Kelly F....Ayuso C.	2017
15	Hereditary hypotrichosis simplex of the scalp. ( 28873114 )	Farah R.S....Swick B.L.	2017
16	<i>CDH3</i> gene related hypotrichosis and juvenile macular dystrophy - A case with a novel mutation. ( 29260097 )	Karti O....Saatci A.O.	2017
17	Novel sequence variants in the LIPH and LPAR6 genes underlies autosomal recessive woolly hair/hypotrichosis in consanguineous families. ( 28425126 )	Ahmad F....Ahmad W.	2017
18	Hypotrichosis with juvenile macular dystrophy: a case report with molecular study. ( 28380103 )	Vicente L.P....Young T.L.	2017
19	Diffuse Palmoplantar Keratoderma, Onychodystrophy, universal Hypotrichosis and Cysts. ( 28871934 )	Arif T....Mohtashim M.	2017
20	Novel homozygous sequence variants in the CDH3 gene encoding P-cadherin underlying hypotrichosis with juvenile macular dystrophy in consanguineous families. ( 27456782 )	Ahmad F....Ahmad W.	2016
21	Autosomal Recessive Hypotrichosis with Woolly Hair Caused by a Mutation in the Keratin 25 Gene Expressed in Hair Follicles. ( 26902920 )	Zernov N.V....Zinchenko R.A.	2016
22	Bimatoprost solution 0.03% topical application to the eyelid margin for the treatment of eyelash hypotrichosis. ( 26873623 )	Arujuna N.R....Farrant P.B.	2016
23	Topical cetirizine and oral vitamin D: a valid treatment for hypotrichosis caused by ectodermal dysplasia. ( 27504742 )	Rossi A....Giustini S.	2016
24	Diffuse hypotrichosis from early childhood. ( 27646750 )	Hermosa-Gelbard A.8....VaA+A^-GalvA!n S.	2016
25	Bimatoprost 0.03% for the Treatment of Eyebrow Hypotrichosis. ( 27124878 )	Carruthers J....Whitcup S.M.	2016
26	Frameshift Sequence Variants in the Human Lipase-H Gene Causing Hypotrichosis. ( 26645693 )	Mehmood S....Ahmad W.	2016
27	Identification of factors contributing to phenotypic divergence via quantitative image analyses of autosomal recessive woolly hair/hypotrichosis with homozygous c.736T&gt;A LIPH mutation. ( 27375176 )	Kinoshita-Ise M....Ohyama M.	2016
28	Mutational analysis of 29 patients with autosomal recessive woolly hair and hypotrichosis: LIPH mutations are extremely predominant in autosomal recessive woolly hair and hypotrichosis in Japan. ( 27641630 )	Takeichi T....Akiyama M.	2016
29	A novel SOX18 mutation uncovered in Jordanian patient with hypotrichosis-lymphedema-telangiectasia syndrome by Whole Exome Sequencing. ( 26631803 )	Bastaki F....Hamzeh A.R.	2016
30	Hypotrichosis with juvenile macular dystrophy: Portuguese case. ( 27617529 )	Elfatoiki F.Z....Afforitit-Demoge A.	2016
31	Phenotypic observations in &quot;hypotrichosis with juvenile macular dystrophy&quot; (recessive CDH3 mutations). ( 26885695 )	Khan A.O....Bolz H.J.	2016
32	Case of autosomal recessive woolly hair/hypotrichosis with atopic dermatitis. ( 27774676 )	Itoh E....Shimomura Y.	2016
33	Hypotrichosis and juvenile macular dystrophy caused by CDH3 mutation: A candidate disease for retinal gene therapy. ( 27157923 )	Singh M.S....MacLaren R.E.	2016
34	Characterization of CDH3-Related Congenital Hypotrichosis With Juvenile Macular Dystrophy. ( 27386845 )	Hull S....Webster A.R.	2016
35	Novel p.Glu519Gln missense mutation in ST14 in a patient with ichthyosis, follicular atrophoderma and hypotrichosis and review of the literature. ( 26596219 )	Neri I....Patrizi A.	2016
36	Analysis of unique mutations in the LPAR6 gene identified in a Japanese family with autosomal recessive woolly hair/hypotrichosis: Establishment of a useful assay system for LPA6. ( 25828854 )	Hayashi R....Shimomura Y.	2015
37	Hypotrichosis, milia, brachydactyly, and frenula. ( 26177262 )	Jeskowiak A....BAPhm M.	2015
38	Aortic Dilatation Associated With a De Novo Mutation inA theA SOX18 Gene: Expanding the Clinical Spectrum ofA Hypotrichosis-Lymphedema-Telangiectasia Syndrome. ( 26148450 )	WA1nnemann F....Preuss C.	2015
39	Identification of mutations in U2HR in two Chinese families with Marie Unna hereditary hypotrichosis. ( 26269244 )	Zhong Z....Chen J.	2015
40	Novel mutation in LIPH in a Lebanese patient with autosomal recessive woolly hair/hypotrichosis. ( 26046953 )	Sleiman M.B....Kurban M.	2015
41	Management of hypotrichosis of the eyelashes: focus on bimatoprost. ( 26020474 )	Fagien S.	2015
42	Novel D323G mutation of DSG4 gene in a girl with localized autosomal recessive hypotrichosis clinically overlapped with monilethrix. ( 26173648 )	Wang J.M....Liang Y.H.	2015
43	Exome sequencing reveals mutation in GJA1 as a cause of keratoderma-hypotrichosis-leukonychia totalis syndrome. ( 26370416 )	Wang H....Yang Y.	2015
44	A Deletion in FOXN1 Is Associated with a Syndrome Characterized by Congenital Hypotrichosis and Short Life Expectancy in Birman Cats. ( 25781316 )	Abitbol M....Tiret L.	2015
45	Exome sequencing reveals novel BCS1L mutations in siblings with hearing loss and hypotrichosis. ( 25895478 )	Zhang J....Tang Z.	2015
46	Topical minoxidil improves congenital hypotrichosis caused by LIPH mutations. ( 25819726 )	Tanahashi K....Akiyama M.	2015
47	Bimatoprost 0.03% for the Treatment of Eyelash Hypotrichosis: A Pooled Safety Analysis of Six Randomized, Double-masked Clinical Trials. ( 26203317 )	Wirta D....VanDenburgh A.	2015
48	Whole-genome SNP genotyping mapped a novel locus for hereditary hypotrichosis on chromosome 2q31.1-q32.2. ( 25999149 )	Jan A....Ahmad W.	2015
49	Identification of a novel mutation, c.686delAins18 (p.Asp229Glyfs*22), in the LIPH gene as a compound heterozygote with c.736T&gt;A (p.Cys246Ser) in autosomal recessive woolly hair/hypotrichosis. ( 25899282 )	Ito T....Tokura Y.	2015
50	A case of hypotrichosis with juvenile macular dystrophy. ( 25621871 )	Mason J.O....Patel S.A.	2015

Sources

Genes for Hypotrichosis

Genes related to Hypotrichosis (2 elite genes):

(show all 34)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MUHH2	Hypotrichosis, Hereditary, Marie Unna Type, 2	Genetic Locus	57.74	MalaCards inferred ⁵⁷ GeneCards inferred via : Gene name (show sections)
2	HYPT9	Hypotrichosis 9	Genetic Locus	57.74	MalaCards inferred ⁵⁷ GeneCards inferred via : Gene name (show sections)
3	DSG4	Desmoglein 4	Protein Coding	55.08	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
4	CDH3	Cadherin 3	Protein Coding	52.37	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
5	HR	HR, Lysine Demethylase And Nuclear Receptor Corepressor	Protein Coding	51.63	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
6	SOX18	SRY-Box 18	Protein Coding	50.86	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
7	CDSN	Corneodesmosin	Protein Coding	50.48	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
8	POC1A	POC1 Centriolar Protein A	Protein Coding	49.72	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
9	DSC3	Desmocollin 3	Protein Coding	48.87	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
10	APCDD1	APC Down-Regulated 1	Protein Coding	48.39	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
11	SNRPE	Small Nuclear Ribonucleoprotein Polypeptide E	Protein Coding	44.5	GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
12	LPAR6	Lysophosphatidic Acid Receptor 6	Protein Coding	44.41	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
13	LIPH	Lipase H	Protein Coding	43.6	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
14	KRT74	Keratin 74	Protein Coding	42.94	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
15	KRT25	Keratin 25	Protein Coding	40.72	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
16	KRT71	Keratin 71	Protein Coding	40.34	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
17	RPL21	Ribosomal Protein L21	Protein Coding	34.57	GeneCards inferred via : Disorders Publications Variants (show sections)
18	DSG1	Desmoglein 1	Protein Coding	30.59	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Variants (show sections)
19	GJA1	Gap Junction Protein Alpha 1	Protein Coding	29.6	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
20	HOXC13	Homeobox C13	Protein Coding	23.99	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
21	DMTN	Dematin Actin Binding Protein	Protein Coding	18.75	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Summaries (show sections)
22	HMU	Hypotrichosis, Marie Unna Type	Genetic Locus	16.2	GeneCards inferred via : Publications Gene name (show sections)
23	DCAF17	DDB1 And CUL4 Associated Factor 17	Protein Coding	13.2	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
24	KRT86	Keratin 86	Protein Coding	13.1	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
25	EPS8L3	EPS8 Like 3	Protein Coding	12.54	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
26	EDA	Ectodysplasin A	Protein Coding	12.34	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
27	ST14	Suppression Of Tumorigenicity 14	Protein Coding	12.3	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
28	WNT10A	Wnt Family Member 10A	Protein Coding	12.29	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
29	EDAR	Ectodysplasin A Receptor	Protein Coding	12.24	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
30	KRT83	Keratin 83	Protein Coding	12.06	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
31	EDARADD	EDAR Associated Death Domain	Protein Coding	12.01	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
32	RMRP	RNA Component Of Mitochondrial RNA Processing Endoribonuclease	RNA Gene	11.96	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
33	GJB2	Gap Junction Protein Beta 2	Protein Coding	11.36	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
34	CLDN1	Claudin 1	Protein Coding	11.26	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)

Sources

Variations for Hypotrichosis

Sources

Expression for Hypotrichosis

Search GEO for disease gene expression data for Hypotrichosis.

Sources

Pathways for Hypotrichosis

Pathways related to Hypotrichosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Developmental Biology ⁶⁶ Show member pathways Axon guidance ⁶⁶	12.71	CDSN DSC3 DSG1 DSG4 KRT25 KRT71
2	Keratinization ⁶⁶ Show member pathways Formation of the cornified envelope ⁶⁶	11.62	CDSN DSC3 DSG1 DSG4 KRT25 KRT71

Sources

GO Terms for Hypotrichosis

Cellular components related to Hypotrichosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament	GO:0005882	9.56	GJA1 KRT25 KRT71 KRT74
2	cell-cell junction	GO:0005911	9.46	CDSN DSC3 DSG1 GJA1
3	cornified envelope	GO:0001533	9.26	CDSN DSC3 DSG1 DSG4
4	desmosome	GO:0030057	8.92	CDSN DSC3 DSG1 DSG4

Biological processes related to Hypotrichosis according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	cell adhesion	GO:0007155	9.85	CDH3 CDSN DSC3 DSG1 DSG4
2	homophilic cell adhesion via plasma membrane adhesion molecules	GO:0007156	9.62	CDH3 DSC3 DSG1 DSG4
3	cell-cell adhesion	GO:0098609	9.56	CDH3 CDSN DSG1 DSG4
4	keratinization	GO:0031424	9.5	CDH3 DSC3 DSG1 DSG4 KRT25 KRT71
5	hair follicle morphogenesis	GO:0031069	9.49	KRT25 KRT71
6	embryonic heart tube development	GO:0035050	9.48	GJA1 SOX18
7	hair follicle development	GO:0001942	9.46	APCDD1 DSG4 HOXC13 SOX18
8	intermediate filament organization	GO:0045109	9.43	KRT25 KRT71
9	hair cycle	GO:0042633	9.4	KRT25 SNRPE
10	hair cycle process	GO:0022405	9.37	CDH3 SOX18
11	cornification	GO:0070268	9.17	CDSN DSC3 DSG1 DSG4 KRT25 KRT71

Sources

Sources for Hypotrichosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia