MCID: HYP087
MIFTS: 42

Hypotrichosis

Categories: Eye diseases, Genetic diseases, Oral diseases, Rare diseases

Aliases & Classifications for Hypotrichosis

MalaCards integrated aliases for Hypotrichosis:

Name: Hypotrichosis 12 74 43 15 39

Classifications:



External Ids:

Disease Ontology 12 DOID:4535
MeSH 43 D007039
NCIt 49 C34720
SNOMED-CT 67 53602002 56558005
UMLS 71 C0020678

Summaries for Hypotrichosis

Disease Ontology : 12 A hair disease that is characterized by sparse hair on the scalp resulting from abnormal hair follicle development and has material basis in mutations in proteins involved in hair growth, division or proliferation of cells within hair follicles.

MalaCards based summary : Hypotrichosis is related to hypotrichosis 7 and hypotrichosis 6. An important gene associated with Hypotrichosis is HYPT9 (Hypotrichosis 9), and among its related pathways/superpathways are Developmental Biology and Keratinization. The drugs Minoxidil and Bimatoprost have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and eye, and related phenotype is integument.

Wikipedia : 74 Hair loss, also known as alopecia or baldness, refers to a loss of hair from part of the head or body.... more...

Related Diseases for Hypotrichosis

Diseases in the Hypotrichosis family:

Hypotrichosis 2 Hypotrichosis 4
Hypotrichosis 8 Hypotrichosis 7
Hypotrichosis 1 Hypotrichosis 6
Hypotrichosis 5 Hypotrichosis 3
Hypotrichosis 9 Hypotrichosis 10
Hypotrichosis 11 Hypotrichosis 12
Hypotrichosis 13 Hypotrichosis 14

Diseases related to Hypotrichosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 263)
# Related Disease Score Top Affiliating Genes
1 hypotrichosis 7 35.2 LPAR6 LIPH KRT74 KRT25 DSG4 CDSN
2 hypotrichosis 6 35.2 LPAR6 LIPH KRT74 KRT71 DSG4
3 hypotrichosis, congenital, with juvenile macular dystrophy 35.1 LPAR6 LIPH DSG4 CDSN CDH3
4 hypotrichosis 8 35.1 LPAR6 LIPH KRT74 KRT25 DSG4 CDSN
5 hypotrichosis 3 35.1 LPAR6 LIPH KRT74 KRT71
6 hypotrichosis 4 35.0 LPAR6 LIPH KRT74 HR CDSN
7 hypotrichosis 13 35.0 LPAR6 LIPH KRT71 KRT25 DSG4
8 hypotrichosis 11 34.9 SNRPE LPAR6 LIPH KRT74
9 hypotrichosis simplex 34.9 SNRPE RPL21 LSS LPAR6 LIPH DSG4
10 hypotrichosis simplex of the scalp 34.3 KRT74 CDSN
11 familial woolly hair syndrome 33.4 LPAR6 LIPH KRT74 KRT71 KRT25
12 monilethrix 33.3 LPAR6 LIPH KRT74 KRT71 KRT25 DSG4
13 keratosis 31.7 GJA1 DSG4 DSG1
14 palmoplantar keratosis 31.4 GJA1 DSG4 DSG1 DSC3
15 hair disease 31.1 SOX18 LSS LPAR6 LIPH KRT74 KRT71
16 darier-white disease 31.0 DSG4 DSC3 CDH3
17 skin disease 30.9 GJA1 DSG4 DSG1 DSC3 CDSN
18 pemphigus 30.8 DSG4 DSG1 DSC3 CDH3
19 pemphigus vulgaris, familial 30.8 DSG4 DSG1 DSC3 CDH3
20 hypotrichosis 2 12.7
21 hypotrichosis-lymphedema-telangiectasia syndrome 12.7
22 hypotrichosis 1 12.6
23 hypotrichosis and recurrent skin vesicles 12.6
24 marie unna congenital hypotrichosis 12.6
25 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 12.6
26 hypotrichosis 12 12.6
27 metaphyseal dysplasia without hypotrichosis 12.6
28 hypotrichosis 14 12.6
29 short stature, onychodysplasia, facial dysmorphism, and hypotrichosis 12.5
30 hypotrichosis 5 12.5
31 spondyloepimetaphyseal dysplasia with hypotrichosis 12.5
32 hypotrichosis 10 12.5
33 hypotrichosis 9 12.5
34 erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper-ige 12.5
35 hypotrichosis-osteolysis-periodontitis-palmoplantar keratoderma syndrome 12.3
36 ichthyosis, congenital, autosomal recessive 11 12.3
37 woolly hair, hypotrichosis, everted lower lip, and outstanding ears 12.3
38 leukomelanoderma, infantilism, mental retardation, hypodontia, hypotrichosis 12.2
39 hypotrichosis, progressive patterned scalp, with wiry hair, onycholysis, and cleft lip/palate 12.2
40 schopf-schulz-passarge syndrome 12.2
41 hypotrichosis-deafness syndrome 12.2
42 brachymetapody-anodontia-hypotrichosis-albinoidism 12.2
43 hypotrichosis of eyelid 12.0
44 congenital hypotrichosis milia 12.0
45 hypotrichosis-intellectual disability, lopes type 12.0
46 bazex syndrome 12.0
47 palmoplantar keratoderma and congenital alopecia 1 12.0
48 woolly hair, autosomal recessive 3 11.9
49 rombo syndrome 11.8
50 ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis 11.8

Graphical network of the top 20 diseases related to Hypotrichosis:



Diseases related to Hypotrichosis

Symptoms & Phenotypes for Hypotrichosis

MGI Mouse Phenotypes related to Hypotrichosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.32 CDH3 DSC3 DSG1 DSG4 GJA1 HR

Drugs & Therapeutics for Hypotrichosis

Drugs for Hypotrichosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Minoxidil Approved, Investigational Phase 4 38304-91-5 4201
2
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
3 Vasodilator Agents Phase 4
4 Antihypertensive Agents Phase 4
5 Pharmaceutical Solutions Phase 4
6 Ophthalmic Solutions Phase 4
7 Dermatologic Agents Phase 4
8 Anti-Bacterial Agents Phase 2
9 Gentamicins Phase 2
10 Anti-Infective Agents Phase 2
11 Orange Approved
12
Glycerol Approved, Investigational 56-81-5 753
13
Zinc Approved, Investigational 7440-66-6 32051
14
Tocopherol Approved, Investigational 1406-66-2, 54-28-4 14986
15
Dihydrotachysterol Approved 67-96-9 5281010 5311071
16
Saw palmetto Approved, Experimental, Investigational
17
Capsaicin Approved 404-86-4 1548943
18
Vitamin C Approved, Nutraceutical 50-81-7 5785 54670067
19
Biotin Approved, Investigational, Nutraceutical 58-85-5 171548
20
Vitamin E Approved, Nutraceutical, Vet_approved 59-02-9 14985
21 Tocotrienol Investigational 6829-55-6
22
Piperine Investigational 94-62-2 638024
23 Vitamin B7
24 Anti-Inflammatory Agents
25 Trace Elements
26 Cytochrome P-450 Enzyme Inhibitors
27 Micronutrients
28 Vitamins
29 Saw palmetto extract
30 Nutrients
31 Tocopherols
32 Antioxidants
33 Hormone Antagonists
34 Tocotrienols
35 Antipruritics
36 Ashwagandha
37 Protective Agents
38 Hormones
39 Maca

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Evaluating the Efficacy of Different Platelet Rich Plasma (PRP) Treatment Regimens in the Management of Androgenetic Alopecia: an Investigator-initiated, Single-center, Single-blinded, Prospective, Randomized Clinical Trial Unknown status NCT02999737 Phase 4
2 Efficacy and Tolerability of Minoxidil 2% for Eyebrow Enhancement : A Randomized , Double-blind , Placebo-controlled , Split-face Comparative Study Completed NCT01672307 Phase 4 Minoxidil lotion 2%;Placebo
3 Study of Bimatoprost Solution in Increasing Eyelash Prominence in African Americans With Eyelash Hypotrichosis Completed NCT00958035 Phase 4 bimatoprost ophthalmic 0.03% solution;vehicle sterile solution (placebo)
4 Minoxidil 1% for Eyebrow Enhancement: A Randomized , Double-blind , Placebo-controlled , Split-face Comparative Study Completed NCT01924000 Phase 4 Minoxidil lotion 1%;Placebo
5 Latisse(Bimatoprost .03% Opthalmic Solution) for the Treatment of Hypotrichosis of the Eyebrows: Latisse Versus Placebo Completed NCT01387906 Phase 4 topical bimatoprost
6 Safety and Efficacy of Bimatoprost Solution in Treating Eyelash Loss or Hypotrichosis in Children Completed NCT01023841 Phase 4 bimatoprost ophthalmic solution 0.03%;Vehicle Sterile Solution
7 Safety and Efficacy of LATISSE® in the Augmentation of Eyelashes of Korean Subjects Completed NCT01229423 Phase 4 bimatoprost 0.03%
8 Study Assessing Patient Satisfaction With LATISSE® for Increasing Eyelash Prominence Completed NCT01448525 Phase 4 bimatoprost ophthalmic solution 0.03%;bimatoprost vehicle solution
9 Safety and Efficacy of Bimatoprost 0.03% Solution for the Treatment of Eyebrow Hypotrichosis: A Phase 4 Investigator Initiated Study Completed NCT01891487 Phase 4 Track A;Track B
10 Bimatoprost 0.03% Solution, NB-UVB and Fractional Carbon Dioxide Laser in Treatment of Generalized Vitiligo Not yet recruiting NCT03487042 Phase 4 Bimatoprost 0.03% ophthalmic solution
11 Bimatoprost for the Treatment of Eyebrow Hypotrichosis Completed NCT01765764 Phase 3 bimatoprost solution;Vehicle to bimatoprost solution
12 Bimatoprost in the Treatment of Eyelash Hypotrichosis Completed NCT01698554 Phase 3 bimatoprost formulation A solution;bimatoprost solution 0.03 %;vehicle of bimatoprost formulation A solution;vehicle of bimatoprost solution 0.03 %
13 A Multicenter, Double-masked, Randomized, Parallel-group Study Assessing the Safety and Efficacy of Once-daily Application of Bimatoprost Solution 0.03% Compared to Vehicle to Treat Chemotherapy-induced Hypotrichosis of the Eyelashes in Japanese Subjects Completed NCT01391286 Phase 3 bimatoprost solution 0.03%;bimatoprost vehicle solution
14 A Multicenter, Double-masked, Randomized, Parallel-group Study Assessing the Safety and Efficacy of Once-Daily Application of Bimatoprost Solution 0.03% Compared to Vehicle in Increasing Overall Eyelash Prominence in Japanese Subjects With Hypotrichosis of the Eyelashes Completed NCT01391273 Phase 3 bimatoprost solution 0.03%;bimatoprost vehicle solution
15 Safety and Efficacy Study of Bimatoprost to Treat Hypotrichosis of the Eyelashes After Application to the Eyelid Margin Completed NCT00907426 Phase 3 Bimatoprost 0.03% solution;Vehicle solution
16 The Role of Bimatoprost Eyelash Gel in Chemotherapy-induced Madarosis: an Analysis of Efficacy and Safety Completed NCT01200251 Phase 3 Bimatoprost eyelash gel
17 Safety and Efficacy of Bimatoprost Ophthalmic Solution in Increasing Eyelash Prominence Completed NCT01064882 Phase 2 bimatoprost ophthalmic solution 0.005%;bimatoprost ophthalmic solution 0.015%;bimatoprost ophthalmic solution 0.03%
18 A Pilot Clinical Trial Investigating the Effect of Autologous Platelet-rich Plasma in Subjects With Mild to Moderate Eyebrow Hypotrichosis Recruiting NCT04018859 Phase 2 Saline
19 The Efficacy of Topical Gentamycin for the Treatment of Hereditary Hypotrichosis Simplex Caused by Heterozygous Nonsense Mutations in CDSN Encoding Corneodesmosin Not yet recruiting NCT03492866 Phase 2 Gentamicin Sulfate
20 An Observational Study of Patients Treated With Bimatoprost 0.03% (Latisse®) for Hypotrichosis of the Eyelashes Completed NCT01623479 bimatoprost 0.03%
21 Safety and Patient Satisfaction With GLASH VISTA™ (Bimatoprost 0.03%) in the Treatment of Eyelash Hypotrichosis in Japan Completed NCT02505776 Bimatoprost cutaneous solution 0.03%
22 A Multi-site, Double-blind, Placebo-controlled Clinical Study to Evaluate the Effects of Viviscal Oral Supplements When Used by Females With Self-perceived Thinning Hair Completed NCT02288858
23 A 6-Month, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Ability and Safety of a Nutraceutical Supplement With Standardized Botanicals to Promote Hair Growth in Women With Self-Perceived Thinning Hair Completed NCT03206567
24 A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Clinical Study to Evaluate the Efficacy of the New Viviscal Professional Strength Oral Supplement in Females With Self-Perceived Thinning Hair Completed NCT02302053
25 A 3-Month, Randomized, Double-Blind, Placebo-Controlled Study Evaluating The Ability Of Viviscal Extra-Strength Formulation To Promote Hair Growth And Decrease Shedding In Women With Self-Perceived Thinning Hair Completed NCT02297360
26 A Randomized, Double-Blind, Placebo-Controlled Study Evaluating The Ability And Safety Of A Nutraceutical Supplement With Standardized Botanicals To Promote Hair Growth In Perimenopausal, Menopausal And Post-Menopausal Women With Self-Perceived Thinning Hair Recruiting NCT04048031
27 A Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Safety and Efficacy of an Oral Nutraceutical Supplement With Standardized Botanicals in Males With Self-Perceived Thinning Hair and Loss Active, not recruiting NCT03709563

Search NIH Clinical Center for Hypotrichosis

Cochrane evidence based reviews: hypotrichosis

Genetic Tests for Hypotrichosis

Anatomical Context for Hypotrichosis

MalaCards organs/tissues related to Hypotrichosis:

40
Skin, Liver, Eye, Bone, Testes, Brain, Heart

Publications for Hypotrichosis

Articles related to Hypotrichosis:

(show top 50) (show all 817)
# Title Authors PMID Year
1
LEF1 haploinsufficiency causes ectodermal dysplasia. 61
32022899 2020
2
Identification of Novel and Recurrent RMRP Variants in a Series of Brazilian Patients with Cartilage-Hair Hypoplasia: McKusick Syndrome. 61
32021596 2020
3
'Metaphyseal dysplasia without hypotrichosis' can present with late-onset extraskeletal manifestations. 61
31413121 2020
4
Natural history of X-linked hypohidrotic ectodermal dysplasia: a 5-year follow-up study. 61
31924237 2020
5
The characterization of hypodontia, hypohidrosis, and hypotrichosis associated with X-linked hypohidrotic ectodermal dysplasia: A systematic review. 61
31981414 2020
6
Correlating Adaptive Optics Images to Clinical Findings in Juvenile Macular Dystrophy with Hypotrichosis in Siblings with Homozygous CDH3 Pathogenic Variation. 61
31927556 2020
7
A novel POC1A variant in an alternatively spliced exon causes classic SOFT syndrome: clinical presentation of seven patients. 61
31767933 2020
8
Mutations in the CDSN gene cause peeling skin disease and hypotrichosis simplex of the scalp. 61
31663161 2020
9
Hypotrichosis with juvenile macular dystrophy. 61
31718366 2019
10
Commentary on Efficacy and Safety of Bimatoprost 0.01% for the Treatment of Eyebrow Hypotrichosis. 61
31135571 2019
11
Efficacy and Safety of Bimatoprost 0.01% for the Treatment of Eyebrow Hypotrichosis: A Randomized, Double-Blind, Vehicle-Controlled Study. 61
30913051 2019
12
Oculodentodigital Dysplasia Diagnosed from Severe Hypotrichosis. 61
31386161 2019
13
A novel and a known mutation in LSS gene associated with hypotrichosis 14 in a Chinese family. 61
31322293 2019
14
Correlation of Dermoscopic and Histopathologic Patterns in Leprosy - A Pilot Study. 61
31807445 2019
15
Successful use of topical minoxidil in the treatment of hypotrichosis associated with desmoplakin mutations. 61
31414503 2019
16
Hypotrichosis with juvenile macular dystrophy: Combination of whole-genome sequencing and genome-wide homozygosity mapping identifies a large deletion in CDH3 initially undetected by whole-exome sequencing-A lesson from next-generation sequencing. 61
31560841 2019
17
Hypohidrotic ectodermal dysplasia: a case report. 61
31694435 2019
18
Homozygous Nonsense Mutation in DSC3 Resulting in Skin Fragility and Hypotrichosis. 61
31790667 2019
19
Novel CDH3 variants in Brazilian families with hypotrichosis and juvenile macular dystrophy revealed by exome sequencing. 61
31696509 2019
20
Treatment of hereditary hypotrichosis simplex of the scalp with topical gentamicin. 61
31746457 2019
21
Palmoplantar keratoderma and perioral keratotic plaques with hypotrichosis in a child. 61
31778560 2019
22
Deleterious Variants in WNT10A, EDAR, and EDA Causing Isolated and Syndromic Tooth Agenesis: A Structural Perspective from Molecular Dynamics Simulations. 61
31652981 2019
23
Sparse scalp hair and vision loss: think hypotrichosis with juvenile macular dystrophy. 61
31645385 2019
24
A unique case of vision loss in a patient with hypotrichosis and juvenile macular dystrophy and primary ciliary dyskinesia. 61
31431935 2019
25
Α de novo 3.8-Mb inversion affecting the EDA and XIST genes in a heterozygous female calf with generalized hypohidrotic ectodermal dysplasia. 61
31533624 2019
26
Biallelic pathogenic variants in the lanosterol synthase gene LSS involved in the cholesterol biosynthesis cause alopecia with intellectual disability, a rare recessive neuroectodermal syndrome. 61
30723320 2019
27
Ectodermal dysplasia - A rare case report. 61
31681695 2019
28
Eyebrow growth pattern analysis in patients with eyebrow hypotrichosis after receiving topical treatment: A retrospective study. 61
31541563 2019
29
Biallelic mutations in the LPAR6 gene causing autosomal recessive wooly hair/hypotrichosis phenotype in five Pakistani families. 61
31077348 2019
30
Treatment of exfoliative cutaneous lupus erythematosus in a German shorthaired pointer dog with mycophenolate mofetil. 61
31038261 2019
31
Functional studies for a dominant mutation in the EDAR gene responsible for hypohidrotic ectodermal dysplasia. 61
31245878 2019
32
Severe dermatitis, multiple allergies and metabolic wasting (SAM) syndrome caused by de novo mutation in the DSP gene misdiagnosed as generalized pustular psoriasis and treatment of acitretin with gabapentin. 61
31106887 2019
33
R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma. 61
31358114 2019
34
Neonatal ichthyosis and hypotrichosis. 61
31290609 2019
35
Ectodermal Dysplasia: Association with Anti-Basement Membrane Autoantibodies. 61
31268817 2019
36
Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin. 61
30425301 2019
37
Comparison of the efficacy and safety of using 0.01% versus 0.03% bimatoprost for the treatment of eyebrow hypotrichosis: A randomized, double-blind, split-face, comparative study. 61
31317662 2019
38
[Hair anomalies in syndromic disorders]. 61
31197391 2019
39
Blepharitis in dogs: a clinical evaluation in 102 dogs. 61
30828906 2019
40
Congenital hypotrichosis in a Simmental cross heifer. 61
30937998 2019
41
Hypotrichosis with keratosis follicular and hyperostosis: a new phenotype due to GJA1 mutation. 61
30811667 2019
42
Expert consensus on the management of Telogen Effluvium in India. 61
31360038 2019
43
Marie Unna hereditary hypotrichosis accompanied by multiple familial trichoepithelioma in a Chinese family. 61
30809827 2019
44
15 keto fluprostenol isopropyl ester (80 µgr/mL) gel for cosmetic eyelash growth and enhancement. 61
30664828 2019
45
Hypohidrotic Ectodermal Dysplasia: A Rare Disorder With Bilateral Infantile Glaucoma. 61
30540672 2019
46
Hypohydrotic Ectodermal Dysplasia in an Indian Family. 61
30925967 2019
47
Off-Label Use of Topical Minoxidil in Alopecia: A Review. 61
30604379 2019
48
Hypotrichosis with cone-rod dystrophy in a patient with cadherin 3 (CDH3) mutation. 61
30710256 2019
49
Mutation-Proved Clouston Syndrome in a Large Indian Family with a Variant Phenotype. 61
30983611 2019
50
SOFT syndrome in a patient from Chile. 61
30569574 2019

Variations for Hypotrichosis

Expression for Hypotrichosis

Search GEO for disease gene expression data for Hypotrichosis.

Pathways for Hypotrichosis

Pathways related to Hypotrichosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.71 KRT74 KRT71 KRT25 DSG4 DSG1 DSC3
2
Show member pathways
11.62 KRT74 KRT71 KRT25 DSG4 DSG1 DSC3

GO Terms for Hypotrichosis

Cellular components related to Hypotrichosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell junction GO:0005911 9.46 DSG4 DSG1 DSC3 CDSN
2 cornified envelope GO:0001533 9.26 DSG4 DSG1 DSC3 CDSN
3 desmosome GO:0030057 8.92 DSG4 DSG1 DSC3 CDSN

Biological processes related to Hypotrichosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.85 DSG4 DSG1 DSC3 CDSN CDH3
2 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.62 DSG4 DSG1 DSC3 CDH3
3 cell-cell adhesion GO:0098609 9.55 DSG4 DSG1 DSC3 CDSN CDH3
4 keratinization GO:0031424 9.5 KRT74 KRT71 KRT25 DSG4 DSG1 DSC3
5 hair follicle morphogenesis GO:0031069 9.48 KRT71 KRT25
6 intermediate filament organization GO:0045109 9.43 KRT71 KRT25
7 hair follicle development GO:0001942 9.43 SOX18 DSG4 APCDD1
8 hair cycle GO:0042633 9.4 SNRPE KRT25
9 hair cycle process GO:0022405 9.37 SOX18 CDH3
10 cornification GO:0070268 9.17 KRT74 KRT71 KRT25 DSG4 DSG1 DSC3

Molecular functions related to Hypotrichosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gamma-catenin binding GO:0045295 8.62 DSG1 DSC3

Sources for Hypotrichosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....