MCID: HYP048
MIFTS: 30

Hypotropia

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Hypotropia

MalaCards integrated aliases for Hypotropia:

Name: Hypotropia 12 76 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9841
ICD9CM 35 378.32
NCIt 50 C42086
SNOMED-CT 68 29491004
UMLS 73 C0152208

Summaries for Hypotropia

MalaCards based summary : Hypotropia is related to hypertropia and exotropia. An important gene associated with Hypotropia is TUBB3 (Tubulin Beta 3 Class III), and among its related pathways/superpathways are Neuroscience and Glioblastoma Multiforme. Affiliated tissues include eye, thyroid and testes, and related phenotypes are behavior/neurological and cellular

Wikipedia : 76 Hypertropia is a condition of misalignment of the eyes (strabismus), whereby the visual axis of one eye... more...

Related Diseases for Hypotropia

Diseases related to Hypotropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 hypertropia 30.7 CHN1 KANTR KIF21A SAMHD1 TUBB3
2 exotropia 30.5 CHN1 KIF21A PHOX2A TUBB3
3 ptosis 30.5 KIF21A PHOX2A TUBB3
4 esotropia 30.5 CHN1 OPTN TUBB3
5 strabismus 28.7 CHN1 FRMD7 KIF21A NF1 PHOX2A TUBB3
6 brown syndrome 10.9
7 fibrosis of extraocular muscles, congenital, 2 10.7 KIF21A PHOX2A
8 marcus gunn phenomenon 10.7 CHN1 TUBB3
9 pathologic nystagmus 10.6 FRMD7 TUBB3
10 congenital ptosis 10.5 CHN1 KIF21A TUBB3
11 deafness, autosomal dominant 28 10.5 CHN1 KIF21A TUBB3
12 kearns-sayre syndrome 10.5 KIF21A PHOX2A TUBB3
13 duane retraction syndrome 10.5 CHN1 KIF21A TUBB3
14 anisometropia 10.5 CHN1 OPTN
15 alternating esotropia 10.4 CHN1 KANTR
16 dissociated nystagmus 10.4 FRMD7 KANTR
17 congenital nystagmus 10.4 FRMD7 TUBB3
18 cerebellopontine angle meningioma 10.4 KANTR SAMHD1
19 oculomotor nerve paralysis 10.3 CHN1 KANTR
20 amblyopia 10.3 CHN1 OPTN TUBB3
21 third cranial nerve disease 10.3 CHN1 KANTR
22 amyloid tumor 10.3 NF1 TUBB3
23 exposure keratitis 10.3 KANTR TUBB3
24 accommodative spasm 10.3 KANTR OPTN
25 scleral staphyloma 10.2 NF1 OPTN
26 poland syndrome 10.2 CHN1 NF1 TUBB3
27 spinal meningioma 10.1 NF1 SAMHD1
28 accommodative esotropia 10.1 CHN1 KANTR SAMHD1
29 hyperhidrosis, gustatory 10.1 KANTR NF1
30 spinal canal and spinal cord meningioma 10.1 NF1 SAMHD1
31 myopia 10.0
32 thyroiditis 10.0
33 facial nerve disease 9.9 KANTR KIF21A PHOX2A TUBB3
34 cerebellopontine angle tumor 9.9 KANTR SAMHD1
35 peripheral nervous system disease 9.9 CHN1 KANTR KIF21A TUBB3
36 ocular motility disease 9.9 CHN1 FRMD7 KIF21A PHOX2A TUBB3
37 nervous system disease 9.9 KANTR OPTN TUBB3
38 internuclear ophthalmoplegia 9.9 KANTR NF1
39 entropion 9.9
40 tukel syndrome 9.8 APPL1 CHN1 KIF21A PHOX2A TUBB3
41 optic nerve neoplasm 9.7 NF1 OPTN
42 purulent endophthalmitis 9.7 OPTN SAMHD1
43 cranial nerve disease 9.3 CHN1 FRMD7 KANTR KIF21A PHOX2A TUBB3
44 paralytic squint 9.3 CHN1 KANTR KIF21A PHOX2A SAMHD1 TUBB3

Graphical network of the top 20 diseases related to Hypotropia:



Diseases related to Hypotropia

Symptoms & Phenotypes for Hypotropia

MGI Mouse Phenotypes related to Hypotropia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 AGT APPL1 CD200 CHN1 GRB2 NF1
2 cellular MP:0005384 10.02 SAMHD1 TPH1 TUBB3 APPL1 CD200 CHN1
3 homeostasis/metabolism MP:0005376 9.96 AGT APPL1 CD200 CHN1 GRB2 NF1
4 mortality/aging MP:0010768 9.85 PDGFRB PHOX2A SAMHD1 TUBB3 AGT APPL1
5 adipose tissue MP:0005375 9.8 AGT APPL1 CHN1 PDGFRB TPH1
6 muscle MP:0005369 9.43 AGT APPL1 CHN1 NF1 PDGFRB TPH1
7 skeleton MP:0005390 9.17 CD200 CHN1 FRMD7 GRB2 NF1 PDGFRB

Drugs & Therapeutics for Hypotropia

Search Clinical Trials , NIH Clinical Center for Hypotropia

Genetic Tests for Hypotropia

Anatomical Context for Hypotropia

MalaCards organs/tissues related to Hypotropia:

41
Eye, Thyroid, Testes

Publications for Hypotropia

Articles related to Hypotropia:

(show all 26)
# Title Authors Year
1
Alternating Hypotropia with Pseudoptosis: A New Phenotype of Congenital Cranial Dysinnervation Disorder. ( 29643789 )
2018
2
Congenital entropion and hypotropia secondary to duplication of the inferior rectus muscle. ( 28089746 )
2017
3
Exotropia and hypotropia as the initial presentation sign of thyroid eye disease in an 18-year-old man. ( 29288834 )
2017
4
To assess the efficacy of vertical muscle surgery for management of hypotropia in monocular elevation deficiency type II. ( 27699607 )
2016
5
Two cases of hypotropia and dissociated vertical deviation treated with oblique muscle surgery. ( 25490238 )
2014
6
Fixation-linked nondissociated hypotropia: a report of 3 cases. ( 25266837 )
2014
7
Exotropia-hypotropia complex in high myopia. ( 24669372 )
2013
8
Surgical management of hypotropia in congenital fibrosis of extraocular muscles (CFEOM) presented by pseudoptosis. ( 23277737 )
2013
9
Managing a case of hypotropia with a positive traction test. ( 23343087 )
2013
10
Diagnosis and surgical treatment of unilateral restrictive hypotropia and esotropia. ( 21397798 )
2011
11
The role of thyroid eye disease and other factors in the overcorrection of hypotropia following unilateral adjustable suture recession of the inferior rectus (an American Ophthalmological Society thesis). ( 22253487 )
2011
12
Acquired cyclic exotropia and hypotropia. ( 19541276 )
2009
13
Dissociated hypotropia: clinical features and surgical management of two cases. ( 17070470 )
2006
14
Spontaneous recovery from inferior rectus contracture (consecutive hypotropia) following local anesthetic injury. ( 12765542 )
2003
15
Fixation linked hypotropia in high myopia. A report of two similar cases. ( 12597767 )
2003
16
A rare case of bilateral dissociated hypotropia and unilateral dissociated esotropia. ( 11304822 )
2001
17
Abduction paralysis with hypotropia: sign of weakness of a contralateral superior oblique. ( 11840359 )
2001
18
Disintegration of the inferior rectus muscle during strabismus surgery for restrictive hypotropia. ( 10928671 )
2000
19
Bilateral inferior rectus muscle recession for correction of hypotropia in dysthyroid ophthalmopathy. ( 10428589 )
1999
20
Postanesthetic hypotropia. ( 9610432 )
1998
21
Postanesthetic hypotropia: a unique syndrome in left eyes. ( 9423914 )
1997
22
Hypercorrection of hypotropia in Graves ophthalmopathy. ( 8433813 )
1993
23
Late overcorrection of hypotropia in Graves ophthalmopathy. Predictive factors. ( 1565447 )
1992
24
Management of ipsilateral ptosis with hypotropia. ( 3096370 )
1986
25
Primary-position hypotropia after anterior transposition of the inferior oblique. ( 3947298 )
1986
26
Infantile contracture of inferior rectus muscle with resultant mechanical hypotropia. ( 5362882 )
1969

Variations for Hypotropia

Expression for Hypotropia

Search GEO for disease gene expression data for Hypotropia.

Pathways for Hypotropia

Pathways related to Hypotropia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.56 AGT NF1 OPTN TPH1 TUBB3
2 11.38 GRB2 NF1 PDGFRB
3 11.08 GRB2 PDGFRB TUBB3

GO Terms for Hypotropia

Cellular components related to Hypotropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vesicle membrane GO:0012506 8.62 APPL1 GRB2

Biological processes related to Hypotropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.43 AGT GRB2 PDGFRB
2 regulation of long-term neuronal synaptic plasticity GO:0048169 9.16 AGT NF1
3 sympathetic nervous system development GO:0048485 8.96 NF1 PHOX2A
4 positive regulation of reactive oxygen species metabolic process GO:2000379 8.8 AGT GRB2 PDGFRB

Molecular functions related to Hypotropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ephrin receptor binding GO:0046875 8.62 CHN1 GRB2

Sources for Hypotropia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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