MCID: HYP048
MIFTS: 27

Hypotropia

Categories: Eye diseases, Neuronal diseases
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Aliases & Classifications for Hypotropia

MalaCards integrated aliases for Hypotropia:

Name: Hypotropia 11 75 14 71 75

Classifications:



External Ids:

Disease Ontology 11 DOID:9841
ICD9CM 34 378.32
NCIt 49 C42086
SNOMED-CT 68 29491004
UMLS 71 C0152208

Summaries for Hypotropia

MalaCards based summary: Hypotropia is related to hypertropia and amblyopia. An important gene associated with Hypotropia is KIF21A (Kinesin Family Member 21A), and among its related pathways/superpathways is Thyroxine (thyroid hormone) production. Affiliated tissues include eye, thyroid and bone, and related phenotypes are homeostasis/metabolism and behavior/neurological

Wikipedia: 75 Hypertropia is a condition of misalignment of the eyes (strabismus), whereby the visual axis of one eye... more...

Related Diseases for Hypotropia

Diseases related to Hypotropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 hypertropia 30.9 ROBO3 PHOX2A KIF21A CHN1
2 amblyopia 30.0 PHOX2A KIF21A FRMD7 CHN1
3 refractive error 29.8 PHOX2A KIF21A CHN1
4 esotropia 29.5 ROBO3 PHOX2A KIF21A FRMD7 CHN1
5 exotropia 29.4 ROBO3 PHOX2A KIF21A FRMD7 CHN1
6 duane retraction syndrome 29.2 ROBO3 PHOX2A KIF21A CHN1
7 congenital fibrosis of the extraocular muscles 29.1 ROBO3 PHOX2A KIF21A FRMD7 CHN1
8 strabismus 28.9 TSPAN12 TSHR ROBO3 PHOX2A KIF21A FRMD7
9 brown syndrome 11.0
10 myopia 10.3
11 graves ophthalmopathy 10.2
12 myotonic cataract 10.2 PHOX2A KIF21A
13 marcus gunn phenomenon 10.2 PHOX2A KIF21A
14 tukel syndrome 10.2 PHOX2A KIF21A
15 fibrosis of extraocular muscles, congenital, 2 10.2 PHOX2A KIF21A
16 abnormal retinal correspondence 10.2 KIF21A CHN1
17 refractive amblyopia 10.1 PHOX2A CHN1
18 fibrosis of extraocular muscles, congenital, 1 10.1 PHOX2A KIF21A
19 microphthalmia, isolated 5 10.1 PHOX2A KIF21A
20 accommodative esotropia 10.1 PHOX2A CHN1
21 strabismic amblyopia 10.1 PHOX2A CHN1
22 eye disease 10.1
23 thyroiditis 10.0 TSHR TPO
24 iodine hypothyroidism 10.0 TSHR TPO
25 optic nerve hypoplasia, bilateral 10.0 KIF21A FRMD7
26 ptosis 10.0
27 suppurative thyroiditis 10.0 TSHR TPO
28 endocrine exophthalmos 10.0 TSHR TPO
29 thyroid crisis 10.0 TSHR TPO
30 paralytic squint 10.0 PHOX2A KIF21A CHN1
31 thyrotoxic exophthalmos 10.0 TSHR TPO
32 duane-radial ray syndrome 10.0 PHOX2A KIF21A CHN1
33 orbital plasma cell granuloma 10.0 TSHR TPO
34 postsurgical hypothyroidism 10.0 TSHR TPO
35 chronic orbital inflammation 10.0 TSHR TPO
36 toxic diffuse goiter 10.0 TSHR TPO
37 cranial nerve disease 10.0 PHOX2A KIF21A FRMD7
38 subacute lymphocytic thyroiditis 10.0 TSHR TPO
39 endemic goiter 10.0 TSHR TPO
40 thyroid dyshormonogenesis 2a 10.0 TSHR TPO
41 plummer's disease 10.0 TSHR TPO
42 nontoxic goiter 10.0 TSHR TPO
43 graves disease 1 9.9 TSHR TPO
44 myxedema 9.9 TSHR TPO
45 hyperthyroxinemia 9.9 TSHR TPO
46 nodular goiter 9.9 TSHR TPO
47 dissociated nystagmus 9.9 ROBO3 FRMD7
48 abducens palsy 9.9
49 duane retraction syndrome 1 9.9
50 neurofibromatosis, type i 9.9

Graphical network of the top 20 diseases related to Hypotropia:



Diseases related to Hypotropia

Symptoms & Phenotypes for Hypotropia

MGI Mouse Phenotypes related to Hypotropia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.86 ATP5PO CHN1 FRMD7 KIF21A PHOX2A ROBO3
2 behavior/neurological MP:0005386 9.5 ATP5PO CHN1 FRMD7 PHOX2A ROBO3 TPO
3 hearing/vestibular/ear MP:0005377 9.46 ROBO3 TPO TSHR TSPAN12
4 vision/eye MP:0005391 9.17 CHN1 FRMD7 KIF21A ROBO3 TPO TSHR

Drugs & Therapeutics for Hypotropia

Search Clinical Trials, NIH Clinical Center for Hypotropia

Genetic Tests for Hypotropia

Anatomical Context for Hypotropia

Organs/tissues related to Hypotropia:

MalaCards : Eye, Thyroid, Bone, Brain

Publications for Hypotropia

Articles related to Hypotropia:

(show top 50) (show all 352)
# Title Authors PMID Year
1
A novel variant in the TSPAN12 gene-presenting as unilateral myopia, pediatric cataract, and heterochromia in a patient with familial exudative vitreoretinopathy. 62
34151585 2022
2
Orbital neuromuscular choristoma of the ophthalmic nerve. 62
34109844 2022
3
Isolated inferior oblique pareses. 62
35583684 2022
4
[Clinical observation of superior rectus transposition with/without augmented suture and vertical rectus transposition for the treatment of strabismus caused by complete abducens nerve palsy]. 62
36069090 2022
5
Muscle fenestration in vertical rectus muscle surgeries. 62
36168236 2022
6
Profile of infantile strabismus at a tertiary eye care center in India. 62
35918972 2022
7
Incidence of A pattern strabismus after inferior rectus recession in patients with Graves' orbitopathy: A retrospective multicentre study. 62
35934887 2022
8
Clinical Characteristics and Surgical Outcomes of Patients with Congenital Fibrosis of the Superior Rectus Muscle. 62
35284981 2022
9
[Clinical characteristics and whole exome sequencing results of patients with Möbius syndrome]. 62
35692026 2022
10
Clinical Profiles and Surgical Outcomes of Strabismus Following Orbital Wall Fractures: A Large Cohort From a Tertiary Eye Care Center. 62
34928761 2022
11
Unilateral Surgery in Bilateral Asymmetrical Dissociated Vertical Deviation With Strong Preferential Fixation. 62
34592873 2022
12
Combined Rectus Muscle Transposition With Posterior Fixation Sutures (Augmented Knapp Procedure) for the Surgical Treatment of Double Elevator Palsy. 62
34435907 2022
13
Effect of inferior oblique muscle belly transposition on versions and vertical alignment in primary position. 62
34142185 2021
14
Whole tendon disinsertion of superior oblique for the treatment of Brown syndrome: a comparative study with multiple techniques. 62
34562622 2021
15
Inferior Rectus Hypoplasia Simulating Contralateral Hypotropia: A Pediatric Case Report. 62
34344129 2021
16
A variant Nishida's technique for surgical correction of monocular elevation deficiency syndrome. 62
34620484 2021
17
Superior oblique tendon thinning as a surgical treatment for Brown syndrome. 62
34271211 2021
18
Orbital tumour or a retained foreign body? An uncommon case of missed diagnosis. 62
33476224 2021
19
Recurrent unilateral restrictive elevation deficit in childhood: a tailored approach. 62
34158322 2021
20
Surgical strategy for third nerve palsy with aberrant regeneration: Harnessing the aberrant power. 62
33727458 2021
21
[Prism-Induced Gaze Shift and Strabismus Treatment for Ocular Motility Disorders and Anomalous Head Posture]. 62
33930929 2021
22
Intraocular Migration of Porous Polyethylene Malar Implant Used for Treacher Collins Eyelid Reconstruction. 62
32732546 2021
23
Strabismus in chronic progressive external ophthalmoplegia. 62
33191655 2021
24
Correlation between uniocular deviation and duction changes following different decompression surgeries in thyroid eye disease. 62
33711978 2021
25
Brown syndrome: clinical features and results of superior oblique tenotomy. 62
33567010 2021
26
Neurovascular compression of the oculomotor nerve presenting with aberrant reinnervation. 62
33426366 2021
27
Neuro-Ophthalmologic Features and Outcomes of Thalamic Infarction: A Single-Institutional 10-Year Experience. 62
31851027 2021
28
Single horizontal rectus muscle vertical augmented transposition with posterior fixation suture in management of monocular elevation deficiency. 62
33410723 2021
29
Evaluation of Diplopia Secondary to Seton Implantation Surgery: Ahmed Glaucoma Valve and Diplopia. 62
33631898 2021
30
Strabismus After Ahmed Glaucoma Valve Implantation. 62
32818449 2021
31
Initial Postoperative Alignment in Strabismus Related to Thyroid Eye Disease. 62
33495794 2021
32
Brown Syndrome: Features and Long-term Results of Management. 62
35005520 2021
33
The Effect of Inferior Rectus Muscle Thickening on Intraocular Pressure in Thyroid-Associated Ophthalmopathy. 62
33564471 2021
34
A variant Nishida's technique for surgical correction of monocular elevation deficiency syndrome. 62
33342631 2020
35
Nontraumatic subperiosteal orbital hemorrhage in a laboring patient with gestational immune thrombocytopenic purpura. 62
33163693 2020
36
Management of esotropia: hypotropia in neurofibromatosis type 1 - simulating myopic strabismus fixus. 62
33334746 2020
37
Strabismus Surgery in Thyroid-Associated Ophthalmopathy; Surgical Outcomes and Surgical Dose Responses. 62
32693696 2020
38
Incidence of symptomatic vertical and torsional diplopia after superior rectus transposition for esotropic Duane syndrome and abducens nerve palsy. 62
33045373 2020
39
Muscle belly union surgery with or without medial rectus recession for the treatment of high myopic strabismus fixus. 62
33045379 2020
40
Suture loop myopexy versus silicone band loop myopexy in the management of myopic strabismus fixus. 62
33045375 2020
41
Post-traumatic superior oblique tendon nodule associated with acquired Brown syndrome. 62
32687877 2020
42
Late reconstruction of extensive orbital floor fracture with a patient-specific implant in a bombing victim. 62
33122461 2020
43
Retro-equatorial inferior oblique myopexy for treatment of inferior oblique overaction. 62
32462341 2020
44
Marcus Gunn jaw winking syndrome in a 6-year-old boy: a new observation. 62
32621984 2020
45
"Yokoyama procedure" efficacy on non-highly myopic patients with acquired esotropia and hypotropia. 62
31106643 2020
46
Heimann-Bielschowsky phenomenon and hypotropic DVD in case of monocular vision loss: a case report. 62
32586290 2020
47
Exotropic heavy eye syndrome in unilateral high axial myopia. 62
32479997 2020
48
Anomalous orbital structure mimicking fracture of orbital floor. 62
32512212 2020
49
Inferior rectus displacement in heavy eye syndrome and sagging eye syndrome. 62
32095879 2020
50
Inflammatory Myofibroblastic Tumor of the Orbit in an 8-Month Old. 62
31880682 2020

Variations for Hypotropia

Expression for Hypotropia

Search GEO for disease gene expression data for Hypotropia.

Pathways for Hypotropia

Pathways related to Hypotropia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.92 TSHR TPO

GO Terms for Hypotropia

Biological processes related to Hypotropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dopaminergic neuron differentiation GO:0071542 8.8 TSHR PHOX2A

Sources for Hypotropia

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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