MCID: HYP048
MIFTS: 30

Hypotropia

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Hypotropia

MalaCards integrated aliases for Hypotropia:

Name: Hypotropia 12 77 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:9841
ICD9CM 36 378.32
NCIt 51 C42086
SNOMED-CT 69 29491004
UMLS 74 C0152208

Summaries for Hypotropia

MalaCards based summary : Hypotropia is related to hypertropia and exotropia. An important gene associated with Hypotropia is KIF21A (Kinesin Family Member 21A), and among its related pathways/superpathways are Glioblastoma Multiforme and G-protein signaling_H-RAS regulation pathway. Affiliated tissues include eye, thyroid and testes, and related phenotypes are behavior/neurological and cellular

Wikipedia : 77 Hypertropia is a condition of misalignment of the eyes (strabismus), whereby the visual axis of one eye... more...

Related Diseases for Hypotropia

Graphical network of the top 20 diseases related to Hypotropia:



Diseases related to Hypotropia

Symptoms & Phenotypes for Hypotropia

MGI Mouse Phenotypes related to Hypotropia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.06 AGT APPL1 CD200 CHN1 GRB2 NF1
2 cellular MP:0005384 10.02 APPL1 CD200 CHN1 GRB2 NF1 PDGFRB
3 growth/size/body region MP:0005378 9.97 AGT APPL1 CHN1 GRB2 NF1 PDGFRB
4 homeostasis/metabolism MP:0005376 9.96 AGT APPL1 CD200 CHN1 GRB2 NF1
5 adipose tissue MP:0005375 9.83 AGT APPL1 CHN1 PDGFRB TPH1
6 immune system MP:0005387 9.76 AGT APPL1 CD200 GRB2 NF1 PDGFRB
7 muscle MP:0005369 9.5 AGT APPL1 CHN1 NF1 PDGFRB TCF21
8 skeleton MP:0005390 9.17 CD200 CHN1 FRMD7 GRB2 NF1 PDGFRB

Drugs & Therapeutics for Hypotropia

Search Clinical Trials , NIH Clinical Center for Hypotropia

Genetic Tests for Hypotropia

Anatomical Context for Hypotropia

MalaCards organs/tissues related to Hypotropia:

42
Eye, Thyroid, Testes

Publications for Hypotropia

Articles related to Hypotropia:

(show all 27)
# Title Authors Year
1
Alternating Hypotropia with Pseudoptosis: A New Phenotype of Congenital Cranial Dysinnervation Disorder. ( 29643789 )
2018
2
Vertical rectus muscle recession versus combined vertical and horizontal rectus muscle recession in patients with thyroid eye disease and hypotropia. ( 30031873 )
2018
3
Congenital entropion and hypotropia secondary to duplication of the inferior rectus muscle. ( 28089746 )
2017
4
Exotropia and hypotropia as the initial presentation sign of thyroid eye disease in an 18-year-old man. ( 29288834 )
2017
5
To assess the efficacy of vertical muscle surgery for management of hypotropia in monocular elevation deficiency type II. ( 27699607 )
2016
6
Two cases of hypotropia and dissociated vertical deviation treated with oblique muscle surgery. ( 25490238 )
2014
7
Fixation-linked nondissociated hypotropia: a report of 3 cases. ( 25266837 )
2014
8
Exotropia-hypotropia complex in high myopia. ( 24669372 )
2013
9
Surgical management of hypotropia in congenital fibrosis of extraocular muscles (CFEOM) presented by pseudoptosis. ( 23277737 )
2013
10
Managing a case of hypotropia with a positive traction test. ( 23343087 )
2013
11
Diagnosis and surgical treatment of unilateral restrictive hypotropia and esotropia. ( 21397798 )
2011
12
The role of thyroid eye disease and other factors in the overcorrection of hypotropia following unilateral adjustable suture recession of the inferior rectus (an American Ophthalmological Society thesis). ( 22253487 )
2011
13
Acquired cyclic exotropia and hypotropia. ( 19541276 )
2009
14
Dissociated hypotropia: clinical features and surgical management of two cases. ( 17070470 )
2006
15
Spontaneous recovery from inferior rectus contracture (consecutive hypotropia) following local anesthetic injury. ( 12765542 )
2003
16
Fixation linked hypotropia in high myopia. A report of two similar cases. ( 12597767 )
2003
17
A rare case of bilateral dissociated hypotropia and unilateral dissociated esotropia. ( 11304822 )
2001
18
Abduction paralysis with hypotropia: sign of weakness of a contralateral superior oblique. ( 11840359 )
2001
19
Disintegration of the inferior rectus muscle during strabismus surgery for restrictive hypotropia. ( 10928671 )
2000
20
Bilateral inferior rectus muscle recession for correction of hypotropia in dysthyroid ophthalmopathy. ( 10428589 )
1999
21
Postanesthetic hypotropia. ( 9610432 )
1998
22
Postanesthetic hypotropia: a unique syndrome in left eyes. ( 9423914 )
1997
23
Hypercorrection of hypotropia in Graves ophthalmopathy. ( 8433813 )
1993
24
Late overcorrection of hypotropia in Graves ophthalmopathy. Predictive factors. ( 1565447 )
1992
25
Management of ipsilateral ptosis with hypotropia. ( 3096370 )
1986
26
Primary-position hypotropia after anterior transposition of the inferior oblique. ( 3947298 )
1986
27
Infantile contracture of inferior rectus muscle with resultant mechanical hypotropia. ( 5362882 )
1969

Variations for Hypotropia

Expression for Hypotropia

Search GEO for disease gene expression data for Hypotropia.

Pathways for Hypotropia

Pathways related to Hypotropia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.84 GRB2 NF1 PDGFRB
2 10.72 GRB2 PDGFRB
3 9.43 GRB2 PDGFRB

GO Terms for Hypotropia

Cellular components related to Hypotropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vesicle membrane GO:0012506 8.62 APPL1 GRB2

Biological processes related to Hypotropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.5 AGT GRB2 PDGFRB
2 regulation of long-term neuronal synaptic plasticity GO:0048169 9.26 AGT NF1
3 sympathetic nervous system development GO:0048485 9.16 NF1 PHOX2A
4 metanephric glomerular capillary formation GO:0072277 8.96 PDGFRB TCF21
5 positive regulation of reactive oxygen species metabolic process GO:2000379 8.8 AGT GRB2 PDGFRB

Molecular functions related to Hypotropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ephrin receptor binding GO:0046875 8.62 CHN1 GRB2

Sources for Hypotropia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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