MCID: HYP048
MIFTS: 26

Hypotropia

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Hypotropia

MalaCards integrated aliases for Hypotropia:

Name: Hypotropia 12 73 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:9841
ICD9CM 34 378.32
NCIt 50 C42086
SNOMED-CT 67 29491004
UMLS 70 C0152208

Summaries for Hypotropia

MalaCards based summary : Hypotropia is related to hypertropia and amblyopia. An important gene associated with Hypotropia is KIF21A (Kinesin Family Member 21A), and among its related pathways/superpathways is Thyroxine (Thyroid Hormone) Production. Affiliated tissues include eye and thyroid, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 73 Hypertropia is a condition of misalignment of the eyes (strabismus), whereby the visual axis of one eye... more...

Related Diseases for Hypotropia

Diseases related to Hypotropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 hypertropia 31.0 ROBO3 PHOX2A KIF21A CHN1
2 amblyopia 30.5 KIF21A CHN1
3 suppression amblyopia 30.5 PHOX2A CHN1
4 exophthalmos 29.6 TSHR TPO
5 exotropia 29.4 SALL4 ROBO3 PHOX2A KIF21A CHN1
6 esotropia 29.2 SALL4 ROBO3 PHOX2A KIF21A FRMD7 CHN1
7 strabismus 28.9 TSHR SALL4 ROBO3 PHOX2A KIF21A FRMD7
8 tukel syndrome 28.8 SALL4 ROBO3 PHOX2A KIF21A FRMD7 CHN1
9 brown syndrome 10.9
10 mechanical strabismus 10.4
11 monocular esotropia 10.2
12 myopia 10.2
13 myotonic cataract 10.2 PHOX2A KIF21A
14 marcus gunn phenomenon 10.2 PHOX2A KIF21A
15 abnormal retinal correspondence 10.2 KIF21A CHN1
16 alternating exotropia 10.2
17 binocular vision disease 10.2 KIF21A CHN1
18 fibrosis of extraocular muscles, congenital, 2 10.2 PHOX2A KIF21A
19 microphthalmia, isolated 5 10.2 PHOX2A KIF21A
20 ametropic amblyopia 10.2 PHOX2A CHN1
21 anisometropia 10.1 PHOX2A CHN1
22 eye disease 10.1
23 transient congenital hypothyroidism 10.1 TSHR TPO
24 iodine hypothyroidism 10.1 TSHR TPO
25 thyroiditis 10.0 TSHR TPO
26 thyroid crisis 10.0 TSHR TPO
27 paralytic squint 10.0 PHOX2A KIF21A CHN1
28 toxic diffuse goiter 10.0 TSHR TPO
29 dissociated nystagmus 10.0 ROBO3 FRMD7
30 congenital ptosis 10.0 PHOX2A KIF21A CHN1
31 subacute lymphocytic thyroiditis 10.0 TSHR TPO
32 endemic goiter 10.0 TSHR TPO
33 ptosis 10.0
34 cranial nerve disease 10.0 PHOX2A KIF21A FRMD7
35 plummer's disease 10.0 TSHR TPO
36 suppurative thyroiditis 10.0 TSHR TPO
37 nontoxic goiter 10.0 TSHR TPO
38 graves disease 1 10.0 TSHR TPO
39 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0 TSHR TPO
40 lagophthalmos 10.0 TSHR PHOX2A KIF21A
41 orbital disease 9.9 TSHR PHOX2A KIF21A
42 myxedema 9.9 TSHR TPO
43 subacute thyroiditis 9.9 TSHR TPO
44 hyperthyroxinemia 9.9 TSHR TPO
45 acute thyroiditis 9.9 TPO ATP5PO
46 nodular goiter 9.9 TSHR TPO
47 duane retraction syndrome 1 9.9
48 fourth cranial nerve palsy 9.9
49 scleral staphyloma 9.9
50 entropion 9.9

Graphical network of the top 20 diseases related to Hypotropia:



Diseases related to Hypotropia

Symptoms & Phenotypes for Hypotropia

MGI Mouse Phenotypes related to Hypotropia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.92 ATP5PO CHN1 FRMD7 PHOX2A ROBO3 SALL4
2 homeostasis/metabolism MP:0005376 9.81 ATP5PO CHN1 FRMD7 KIF21A PHOX2A ROBO3
3 hearing/vestibular/ear MP:0005377 9.56 ROBO3 SALL4 TPO TSHR
4 mortality/aging MP:0010768 9.56 ATP5PO CHN1 KIF21A PHOX2A ROBO3 SALL4
5 vision/eye MP:0005391 9.1 CHN1 FRMD7 KIF21A SALL4 TPO TSHR

Drugs & Therapeutics for Hypotropia

Search Clinical Trials , NIH Clinical Center for Hypotropia

Genetic Tests for Hypotropia

Anatomical Context for Hypotropia

MalaCards organs/tissues related to Hypotropia:

40
Eye, Thyroid

Publications for Hypotropia

Articles related to Hypotropia:

(show top 50) (show all 332)
# Title Authors PMID Year
1
Surgical strategy for third nerve palsy with aberrant regeneration: Harnessing the aberrant power. 61
33727458 2021
2
Neuro-Ophthalmologic Features and Outcomes of Thalamic Infarction: A Single-Institutional 10-Year Experience. 61
31851027 2021
3
Neurovascular compression of the oculomotor nerve presenting with aberrant reinnervation. 61
33426366 2021
4
Brown syndrome: clinical features and results of superior oblique tenotomy. 61
33567010 2021
5
Intraocular Migration of Porous Polyethylene Malar Implant Used for Treacher Collins Eyelid Reconstruction. 61
32732546 2021
6
Strabismus in chronic progressive external ophthalmoplegia. 61
33191655 2021
7
Correlation between uniocular deviation and duction changes following different decompression surgeries in thyroid eye disease. 61
33711978 2021
8
Evaluation of Diplopia Secondary to Seton Implantation Surgery: Ahmed Glaucoma Valve and Diplopia. 61
33631898 2021
9
Strabismus After Ahmed Glaucoma Valve Implantation. 61
32818449 2021
10
Initial Postoperative Alignment in Strabismus Related to Thyroid Eye Disease. 61
33495794 2021
11
Orbital tumour or a retained foreign body? An uncommon case of missed diagnosis. 61
33476224 2021
12
The Effect of Inferior Rectus Muscle Thickening on Intraocular Pressure in Thyroid-Associated Ophthalmopathy. 61
33564471 2021
13
Single horizontal rectus muscle vertical augmented transposition with posterior fixation suture in management of monocular elevation deficiency. 61
33410723 2021
14
Nontraumatic subperiosteal orbital hemorrhage in a laboring patient with gestational immune thrombocytopenic purpura. 61
33163693 2020
15
A variant Nishida's technique for surgical correction of monocular elevation deficiency syndrome. 61
33342631 2020
16
Management of esotropia: hypotropia in neurofibromatosis type 1 - simulating myopic strabismus fixus. 61
33334746 2020
17
Suture loop myopexy versus silicone band loop myopexy in the management of myopic strabismus fixus. 61
33045375 2020
18
Strabismus Surgery in Thyroid-Associated Ophthalmopathy; Surgical Outcomes and Surgical Dose Responses. 61
32693696 2020
19
Muscle belly union surgery with or without medial rectus recession for the treatment of high myopic strabismus fixus. 61
33045379 2020
20
Incidence of symptomatic vertical and torsional diplopia after superior rectus transposition for esotropic Duane syndrome and abducens nerve palsy. 61
33045373 2020
21
Post-traumatic superior oblique tendon nodule associated with acquired Brown syndrome. 61
32687877 2020
22
Late reconstruction of extensive orbital floor fracture with a patient-specific implant in a bombing victim. 61
33122461 2020
23
Retro-equatorial inferior oblique myopexy for treatment of inferior oblique overaction. 61
32462341 2020
24
Marcus Gunn jaw winking syndrome in a 6-year-old boy: a new observation. 61
32621984 2020
25
"Yokoyama procedure" efficacy on non-highly myopic patients with acquired esotropia and hypotropia. 61
31106643 2020
26
Heimann-Bielschowsky phenomenon and hypotropic DVD in case of monocular vision loss: a case report. 61
32586290 2020
27
Anomalous orbital structure mimicking fracture of orbital floor. 61
32512212 2020
28
Exotropic heavy eye syndrome in unilateral high axial myopia. 61
32479997 2020
29
Inflammatory Myofibroblastic Tumor of the Orbit in an 8-Month Old. 61
31880682 2020
30
Inferior rectus displacement in heavy eye syndrome and sagging eye syndrome. 61
32095879 2020
31
Heavy eye syndrome precipitated by superotemporal Ahmed glaucoma valve implantation in a woman with axial high myopia. 61
31953024 2020
32
Comparison of different tendon transposition techniques for the treatment of monocular elevation deficiency type 2. 61
31901510 2020
33
Single Muscle Transposition in the Management of Monocular Elevation Deficiency. 61
31852364 2020
34
[Temporary elevation deficit with exophthalmos in a 4-year-old child]. 61
30953126 2020
35
[Strabismus and oculomotor disorders induced by injection anesthesia for cataract surgery]. 61
33063964 2020
36
Acquired monocular elevation deficit in a case of Parry-Romberg syndrome. 61
31621456 2019
37
Nasal loop myopexy as a primary procedure to correct exotropia hypotropia complex in high myopia. 61
31612771 2019
38
Treatment of acquired Brown syndrome in a child with a single intramuscular systemic depot steroid injection. 61
31145990 2019
39
A Convergence of Ophthalmic and Life-threatening Emergencies: Acute Angle Closure Glaucoma and Subarachnoid Hemorrhage. 61
31233457 2019
40
Eye Conditions in Infants and Children: Amblyopia and Strabismus. 61
31454213 2019
41
[Clinical effects of surgical treatment of high myopic strabismus fixus by modified Yokoyama's surgery combined with medial rectus muscle recession]. 61
31495152 2019
42
Unilateral inferior oblique anterior transposition for markedly asymmetric dissociated vertical deviation with unilateral inferior oblique over-action. 61
31455265 2019
43
Pulled into two syndrome (PITS) in a case of congenital fibrosis of the extraocular muscle. 61
31238477 2019
44
Zygomatic dental implant induced orbital fracture and inferior oblique trauma. 61
29565705 2019
45
Single Horizontal Muscle (Medial or Lateral Rectus) Transposition and Inferior Rectus Recession in Monocular Elevation Deficit: A Novel Surgical Technique. 61
31116867 2019
46
Outcome of inferior oblique disinsertion versus myectomy in the surgical treatment of unilateral congenital superior oblique palsy. 61
30885810 2019
47
Adherence syndrome following inferior oblique anteropositioning - a case report. 61
30570375 2019
48
Damage to the inferior oblique muscle branch of the oculomotor nerve: a complication during orbital fat decompression. 61
29423785 2019
49
[Brown's syndrome]. 61
30711379 2019
50
Atypical Case of Rosai-Dorfman Disease of the Lacrimal Gland with Adjacent Bone Erosion. 61
30976592 2019

Variations for Hypotropia

Expression for Hypotropia

Search GEO for disease gene expression data for Hypotropia.

Pathways for Hypotropia

Pathways related to Hypotropia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.4 TSHR TPO

GO Terms for Hypotropia

Biological processes related to Hypotropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dopaminergic neuron differentiation GO:0071542 8.62 TSHR PHOX2A

Sources for Hypotropia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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