ARCI9
MCID: ICH048
MIFTS: 33
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Ichthyosis, Congenital, Autosomal Recessive 9 (ARCI9)
Categories:
Eye diseases, Fetal diseases, Genetic diseases, Rare diseases, Respiratory diseases, Skin diseases
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MalaCards integrated aliases for Ichthyosis, Congenital, Autosomal Recessive 9:
Characteristics:Inheritance:
Autosomal recessive 57
Classifications:
MalaCards categories:
Global: Genetic diseases Rare diseases Fetal diseases Anatomical: Skin diseases Eye diseases Respiratory diseases
ICD10:
31
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OMIM®: 57 Autosomal recessive congenital ichthyosis (ARCI) is a heterogeneous group of disorders of keratinization characterized primarily by abnormal skin scaling over the whole body. These disorders are limited to skin, with approximately two-thirds of patients presenting severe symptoms. The main skin phenotypes are lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur (summary by Fischer, 2009). Neither histopathologic findings nor ultrastructural features clearly distinguish between NCIE and LI. In addition, mutations in several genes have been shown to cause both lamellar and nonbullous ichthyosiform erythrodermal phenotypes (Akiyama et al., 2003). At the First Ichthyosis Consensus Conference in Soreze in 2009, the term 'autosomal recessive congenital ichthyosis' (ARCI) was designated to encompass LI, NCIE, and harlequin ichthyosis (ARCI4B; 242500) (Oji et al., 2010). NCIE is characterized by prominent erythroderma and fine white, superficial, semiadherent scales. Most patients present with collodion membrane at birth and have palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume. In half of the cases, a nail dystrophy including ridging, subungual hyperkeratosis, or hypoplasia has been described. Ectropion, eclabium, scalp involvement, and loss of eyebrows and lashes seem to be more frequent in NCIE than in lamellar ichthyosis (summary by Fischer et al., 2000). In LI, the scales are large, adherent, dark, and pigmented with no skin erythema. Overlapping phenotypes may depend on the age of the patient and the region of the body. The terminal differentiation of the epidermis is perturbed in both forms, leading to a reduced barrier function and defects of lipid composition in the stratum corneum (summary by Lefevre et al., 2006). In later life, the skin in ARCI may have scales that cover the entire body surface, including the flexural folds, and the scales are highly variable in size and color. Erythema may be very mild and almost invisible. Some affected persons exhibit scarring alopecia, and many have secondary anhidrosis (summary by Eckl et al., 2005). For a general phenotypic description and discussion of genetic heterogeneity of autosomal recessive congenital ichthyosis, see ARCI1 (242300). (615023) (Updated 08-Dec-2022) MalaCards based summary: Ichthyosis, Congenital, Autosomal Recessive 9, also known as autosomal recessive congenital ichthyosis 9, is related to weill-marchesani syndrome 4 and autosomal recessive congenital ichthyosis. An important gene associated with Ichthyosis, Congenital, Autosomal Recessive 9 is CERS3 (Ceramide Synthase 3), and among its related pathways/superpathways is 22q11.2 copy number variation syndrome. Affiliated tissues include skin, and related phenotypes are hyperkeratosis and hypohidrosis UniProtKB/Swiss-Prot: 73 A form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs. Disease Ontology: 11 An autosomal recessive congenital ichthyosis characterized by fine erythrodermic scales, palmoplantar hyperlinearity, thick orthohyperkeratosis, hypergranulosis, moderate acanthosis and mild alopecia that has material basis in homozygous mutation in the CERS3 gene on chromosome 15q26. |
Human phenotypes related to Ichthyosis, Congenital, Autosomal Recessive 9:30 (show all 10)
Symptoms via clinical synopsis from OMIM®:57 (Updated 08-Dec-2022)Clinical features from OMIM®:615023 (Updated 08-Dec-2022) |
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Organs/tissues related to Ichthyosis, Congenital, Autosomal Recessive 9:
MalaCards :
Skin
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Articles related to Ichthyosis, Congenital, Autosomal Recessive 9:
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ClinVar genetic disease variations for Ichthyosis, Congenital, Autosomal Recessive 9:5
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GEO
for disease gene expression data for Ichthyosis, Congenital, Autosomal Recessive 9.
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