MCID: ICH018
MIFTS: 18

Ichthyosis Linearis Circumflexa

Categories: Rare diseases

Aliases & Classifications for Ichthyosis Linearis Circumflexa

MalaCards integrated aliases for Ichthyosis Linearis Circumflexa:

Name: Ichthyosis Linearis Circumflexa 54 74

Classifications:



External Ids:

UMLS 74 C0265962

Summaries for Ichthyosis Linearis Circumflexa

MalaCards based summary : Ichthyosis Linearis Circumflexa is related to netherton syndrome and ichthyosis, and has symptoms including trichorrhexis invaginata An important gene associated with Ichthyosis Linearis Circumflexa is SPINK5 (Serine Peptidase Inhibitor, Kazal Type 5). The drugs Adalimumab and Pimecrolimus have been mentioned in the context of this disorder. Affiliated tissues include skin.

Wikipedia : 77 Ichthyosis linearis circumflexa is a distinctive skin condition of generalized hyperkeratosis and... more...

Related Diseases for Ichthyosis Linearis Circumflexa

Diseases related to Ichthyosis Linearis Circumflexa via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 netherton syndrome 12.4
2 ichthyosis 11.1
3 dwarfism 10.4

Symptoms & Phenotypes for Ichthyosis Linearis Circumflexa

UMLS symptoms related to Ichthyosis Linearis Circumflexa:


trichorrhexis invaginata

Drugs & Therapeutics for Ichthyosis Linearis Circumflexa

Drugs for Ichthyosis Linearis Circumflexa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 2 331731-18-1 16219006
2
Pimecrolimus Approved, Investigational Phase 1, Phase 2 137071-32-0 17753757 6447131
3
Tacrolimus Approved, Investigational Phase 1, Phase 2 104987-11-3 445643 439492 6473866
4 Anti-Inflammatory Agents Phase 2,Phase 1
5 Antirheumatic Agents Phase 2,Phase 1
6 Analgesics, Non-Narcotic Phase 1, Phase 2
7 Calcineurin Inhibitors Phase 1, Phase 2
8 Dermatologic Agents Phase 1, Phase 2
9 Immunologic Factors Phase 1, Phase 2,Phase 2
10 Analgesics Phase 1, Phase 2
11 Peripheral Nervous System Agents Phase 1, Phase 2
12 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
13 Immunosuppressive Agents Phase 1, Phase 2
14 Antibodies, Monoclonal Phase 2
15 Immunoglobulins Phase 2
16 Antibodies Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Trial Using Humira in Netherton Syndrome Completed NCT02113904 Phase 2 Adalimumab
2 Safety Study of Elidel (Pimecrolimus) 1% Cream to Treat Netherton Syndrome Completed NCT00208026 Phase 1, Phase 2 Pimecrolimus 1% Cream
3 The Efficacy and Safety of Secukinumab in Patients With Ichthyoses Active, not recruiting NCT03041038 Phase 2 Secukinumab;Placebo
4 Gene Therapy for Netherton Syndrome Unknown status NCT01545323 Phase 1
5 A Study Evaluating the Safety and Efficacy of Topical BPR277 for the Treatment of Atopic Dermatitis and Netherton Syndrome Completed NCT01428297 Phase 1 BPR277 ointment (controlled application);Placebo (Vehicle);BPR277 ointment;Placebo (Vehicle);BPR277;Placebo (Vehicle)
6 Natural History and Biological Study of Netherton Syndrome Unknown status NCT02081313 Not Applicable
7 Defining the Skin and Blood Biomarkers of Ichthyosis Recruiting NCT03417856
8 Natural History of Diseases Associated With Allergic Inflammation: Atopic Dermatitis and Genetic and Congenital Diseases Associated With Atopic Pathways Recruiting NCT01164241

Search NIH Clinical Center for Ichthyosis Linearis Circumflexa

Genetic Tests for Ichthyosis Linearis Circumflexa

Anatomical Context for Ichthyosis Linearis Circumflexa

MalaCards organs/tissues related to Ichthyosis Linearis Circumflexa:

42
Skin

Publications for Ichthyosis Linearis Circumflexa

Articles related to Ichthyosis Linearis Circumflexa:

(show all 25)
# Title Authors Year
1
Ichthyosis linearis circumflexa with bamboo hair: challenges in the diagnosis and management. ( 28554884 )
2017
2
ICHTHYOSIS LINEARIS CIRCUMFLEXA: NOT ALWAYS A PART OF NETHERTON SYNDROME. ( 30204963 )
2016
3
Ichthyosis Linearis Circumflexa as the Only Clinical Manifestation of Netherton Syndrome. ( 25710899 )
2015
4
Ichthyosis linearis circumflexa in a child. Response to narrowband UVB therapy. ( 26848320 )
2015
5
Netherton syndrome with ichthyosis linearis circumflexa and trichorrhexis invaginatum. ( 25526335 )
2014
6
Ichthyosis linearis circumflexa. ( 21220804 )
2010
7
A Japanese infant with localized ichthyosis linearis circumflexa on the palms and soles harbouring a compound heterozygous mutation in the SPINK5 gene. ( 16120162 )
2005
8
Clearance of ichthyosis linearis circumflexa with balneophototherapy. ( 11305383 )
2000
9
A case of ichthyosis linearis circumflexa successfully treated with topical tacrolimus. ( 10688732 )
2000
10
Ichthyosis linearis circumflexa. ( 20948134 )
1996
11
Ichthyosis linearis circumflexa: morphological and biochemical studies. ( 2579669 )
1985
12
Successful therapy of ichthyosis linearis circumflexa with PUVA. ( 6863655 )
1983
13
Ichthyosis linearis circumflexa [proceedings]. ( 7387896 )
1980
14
Ichthyosis linearis circumflexa ComA"l and Netherton's syndrome; an ultrastructural study. ( 467759 )
1979
15
Explorations of antimitotic agents in the treatment of a congenital disease, ichthyosis linearis circumflexa. ( 439902 )
1979
16
Ichthyosis linearis circumflexa. ( 479434 )
1979
17
Ichthyosis linearis circumflexa comA"l. A clinico-statistical approach to its relationship with Netherton's syndrome. ( 4480416 )
1974
18
Ichthyosis linearis circumflexa comA"l with trichorrhexis invaginata (Netherton's syndrome). A light microscopical study of the skin changes. ( 4480415 )
1974
19
Ichthyosis linearis circumflexa and Netherton's syndrome with idiopathic dwarfism. ( 4800202 )
1973
20
Ichthyosis linearis circumflexa ComA"l with Trichorrhexis invaginata (Netherton's Syndrom): an ultrastructural study of the skin changes. ( 4678924 )
1972
21
Netherton's disease and ichthyosis linearis circumflexa. Report of a case and review of the literature. ( 4115884 )
1972
22
Netherton's syndrome and ichthyosis linearis circumflexa. ( 5467454 )
1970
23
Netherton's disease and ichthyosis linearis circumflexa. ( 5797972 )
1969
24
Neterton's syndrome and ichthyosis linearis circumflexa. ( 4242601 )
1969
25
Multiple defects of the hair shaft in Netherton's disease. Association with ichthyosis linearis circumflexa. ( 5359904 )
1969

Variations for Ichthyosis Linearis Circumflexa

Expression for Ichthyosis Linearis Circumflexa

Search GEO for disease gene expression data for Ichthyosis Linearis Circumflexa.

Pathways for Ichthyosis Linearis Circumflexa

GO Terms for Ichthyosis Linearis Circumflexa

Sources for Ichthyosis Linearis Circumflexa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....