MCID: IDM001
MIFTS: 37

Ideomotor Apraxia

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Ideomotor Apraxia

MalaCards integrated aliases for Ideomotor Apraxia:

Name: Ideomotor Apraxia 12 15 17
Apraxia, Ideomotor 73 44 70
Transcortical Apraxia 12
Limb-Kinetic Apraxia 12
Ideomotor Dyspraxia 12
Classic Apraxia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4627
MeSH 44 D020240
SNOMED-CT 67 39746003
UMLS 70 C0234523

Summaries for Ideomotor Apraxia

MalaCards based summary : Ideomotor Apraxia, also known as apraxia, ideomotor, is related to apraxia and brain injury, and has symptoms including other symbolic dysfunction An important gene associated with Ideomotor Apraxia is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways are Pathways of neurodegeneration - multiple diseases and Alzheimers Disease. Affiliated tissues include cortex, parietal lobe and brain, and related phenotypes are cellular and growth/size/body region

Wikipedia : 73 Ideomotor Apraxia, often IMA, is a neurological disorder characterized by the inability to correctly... more...

Related Diseases for Ideomotor Apraxia

Diseases related to Ideomotor Apraxia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
# Related Disease Score Top Affiliating Genes
1 apraxia 31.9 MAPT GRN C9orf72 APOE
2 brain injury 30.6 MAPT APOE
3 finger agnosia 30.4 MIR4277 MAPT
4 amnestic disorder 30.4 MAPT BCHE APOE
5 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 30.2 PRNP MAPT GRN
6 dysgraphia 29.9 TARDBP MAPT GRN FUS C9orf72
7 gerstmann syndrome 29.5 PSEN2 PRNP MAPT GRN APOE
8 parkinson disease, late-onset 29.4 SNCA PSEN2 PRNP MAPT BCHE APOE
9 agraphia 29.2 TARDBP PRNP MIR4277 MAPT GRN C9orf72
10 nominal aphasia 29.1 TARDBP MAPT GRN FUS C9orf72 APOE
11 huntington disease 29.1 TARDBP SNCA PSEN2 PRNP MAPT C9orf72
12 alzheimer disease 29.0 TARDBP SNCA PSEN2 PRNP MAPT GRN
13 aphasia 28.9 TARDBP SNCA PSEN2 PRNP MAPT GRN
14 dystonia 28.8 GRN FUS C9orf72 APOE
15 dementia 27.8 TARDBP SNCA PSEN2 PRNP MAPT GRN
16 supranuclear palsy, progressive, 1 27.8 TARDBP SNCA PSEN2 PRNP MAPT GRN
17 traumatic brain injury 10.3
18 chromosome 17q21.31 duplication syndrome 10.2 SNCA MAPT
19 color agnosia 10.2 SNCA GRN
20 capgras syndrome 10.2 SNCA BCHE
21 subjective cognitive decline 10.2 MAPT APOE
22 posterior cortical atrophy 10.2 MAPT APOE
23 coenzyme q10 deficiency, primary, 1 10.2 SNCA MAPT
24 hemiplegia 10.2
25 agnosia 10.2
26 corticobasal degeneration 10.2
27 alzheimer disease 10 10.2 MAPT APOE
28 alzheimer disease 9 10.2 SNCA MAPT
29 binswanger's disease 10.2 MAPT APOE
30 parkinson disease 3, autosomal dominant 10.2 SNCA MAPT
31 age-related hearing loss 10.2 MAPT APOE
32 atypical autism 10.2 SNCA BCHE
33 neuronal intranuclear inclusion disease 10.2 SNCA MAPT
34 locked-in syndrome 10.1 TARDBP FUS
35 postencephalitic parkinson disease 10.1 TARDBP SNCA MAPT
36 parkinson disease 1, autosomal dominant 10.1 SNCA MAPT
37 amyotrophic lateral sclerosis 11 10.1 TARDBP FUS
38 cerebral amyloid angiopathy, app-related 10.1 PSEN2 APOE
39 phonagnosia 10.1 C9orf72 BCHE
40 giant axonal neuropathy 2 10.1 TARDBP FUS
41 mild cognitive impairment 10.1 MAPT BCHE APOE
42 dysautonomia 10.1 SNCA PRNP
43 meningioma, familial 10.1
44 brain meningioma 10.1
45 intracranial meningioma 10.1
46 secretory meningioma 10.1
47 lymphoplasmacyte-rich meningioma 10.1
48 alien hand syndrome 10.1
49 marchiafava bignami disease 10.1
50 alzheimer disease 2 10.1 PSEN2 MAPT APOE

Graphical network of the top 20 diseases related to Ideomotor Apraxia:



Diseases related to Ideomotor Apraxia

Symptoms & Phenotypes for Ideomotor Apraxia

UMLS symptoms related to Ideomotor Apraxia:


other symbolic dysfunction

MGI Mouse Phenotypes related to Ideomotor Apraxia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.11 APOE C9orf72 GRN MAPT PRNP PSEN2
2 growth/size/body region MP:0005378 10.09 APOE C9orf72 GRN MAPT PRNP PSEN2
3 homeostasis/metabolism MP:0005376 10.07 APOE BCHE C9orf72 GRN MAPT PRNP
4 hematopoietic system MP:0005397 10.01 APOE C9orf72 GRN MAPT PRNP PSEN2
5 immune system MP:0005387 9.92 APOE C9orf72 GRN MAPT PRNP PSEN2
6 nervous system MP:0003631 9.81 APOE C9orf72 GRN MAPT PRNP PSEN2
7 integument MP:0010771 9.8 APOE C9orf72 GRN MAPT PRNP PSEN2
8 no phenotypic analysis MP:0003012 9.5 APOE C9orf72 GRN MAPT PRNP SNCA
9 taste/olfaction MP:0005394 8.8 APOE MAPT SNCA

Drugs & Therapeutics for Ideomotor Apraxia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Event-Related fMRI Analysis of Patients With Ideomotor Apraxia During Transitive and Intransitive Hand Gesturing Completed NCT00063115
2 EEG Analysis of Ideomotor Apraxia Completed NCT00024999
3 Early-onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural Networks Recruiting NCT03153371

Search NIH Clinical Center for Ideomotor Apraxia

Cochrane evidence based reviews: apraxia, ideomotor

Genetic Tests for Ideomotor Apraxia

Anatomical Context for Ideomotor Apraxia

MalaCards organs/tissues related to Ideomotor Apraxia:

40
Cortex, Parietal Lobe, Brain, Bone

Publications for Ideomotor Apraxia

Articles related to Ideomotor Apraxia:

(show top 50) (show all 295)
# Title Authors PMID Year
1
Feasibility of combining functional near-infrared spectroscopy with electroencephalography to identify chronic stroke responders to cerebellar transcranial direct current stimulation-a computational modeling and portable neuroimaging methodological study. 61
33675516 2021
2
Neurocognitive assessment and DNA sequencing expand the phenotype and genotype spectrum of Alström syndrome. 61
33410256 2021
3
Body representation in people with apraxia post Stroke- an observational study. 61
33587684 2021
4
Effectiveness of a functional rehabilitation program for upper limb apraxia in poststroke patients: A randomized controlled trial. 61
33485836 2021
5
Diagnosis of complex regional pain syndrome type 1 in patients with corticobasal degeneration: a case report. 61
32954740 2020
6
A 57-Year-Old Woman With Progressive Left Hand Clumsiness and Falls. 61
31745473 2019
7
Motor, cognitive and behavioral differences in MDS PSP phenotypes. 61
30989369 2019
8
A Case of Overlap Posterior Cortical Atrophy and Logopenic Variant Primary Progressive Aphasia. 61
30817493 2019
9
Reversible splenial lesion syndrome after blood transfusion presents callosal disconnection syndrome: A case report. 61
29901639 2018
10
A progressive breakdown of the body in space. 61
29882467 2018
11
Diagnosing Corticobasal Syndrome Based on the Presence of Visual Hallucinations and Imaging with Amyloid Positron Emission Tomography. 61
29269636 2018
12
Assessment of the praxis circuit in glioma surgery to reduce the incidence of postoperative and long-term apraxia: a new intraoperative test. 61
29473778 2018
13
Unilateral Apraxic Agraphia without Ideomotor Apraxia from a callosal lesion in a patient with Marchiafava-Bignami disease. 61
29482459 2018
14
Limb apraxia and the left parietal lobe. 61
29519468 2018
15
The Progressive Acalculia Presentation of Parietal Variant Alzheimer's Disease. 61
29710718 2018
16
A Case of Recurrent Ischemic Stroke due to Intravascular Lymphomatosis, Undiagnosed by Random Skin Biopsy and Brain Imaging. 61
29279711 2017
17
Crossover learning of gestures in two ideomotor apraxia patients: A single case experimental design study. 61
26610072 2017
18
Corticobasal syndrome due to sporadic Creutzfeldt-Jakob disease: a review and neuropsychological case report. 61
27871202 2017
19
Callosal ideomotor apraxia in Alzheimer's disease. 61
27829324 2017
20
Motor Adaptation Deficits in Ideomotor Apraxia. 61
28205499 2017
21
Primary progressive apraxia: an unusual ideomotor syndrome. 61
29375885 2017
22
Hand-independent representation of tool-use pantomimes in the left anterior intraparietal cortex. 61
27591782 2016
23
Ideomotor limb apraxia as a staging tool in individuals with Alzheimer's disease (ILIAD). 61
27901517 2016
24
Ideomotor Apraxia Due to Injury of the Superior Longitudinal Fasciculus. 61
27003199 2016
25
Pantomime Production by People With Aphasia: What Are Influencing Factors? 61
27387394 2016
26
Dysfunction of the Human Mirror Neuron System in Ideomotor Apraxia: Evidence from Mu Suppression. 61
26942323 2016
27
Callosal apraxia: a 34-year follow-up study. 61
26928117 2016
28
An autopsy case of frontotemporal lobar degeneration with the appearance of fused in sarcoma inclusions (basophilic inclusion body disease) clinically presenting corticobasal syndrome. 61
26227957 2016
29
Functional rehabilitation of upper limb apraxia in poststroke patients: study protocol for a randomized controlled trial. 61
26542104 2015
30
Multiple Intracerebral Hemorrhages in an Old Patient with Rheumatoid Arthritis. 61
26939215 2015
31
Left parietal cortex transcranial direct current stimulation enhances gesture processing in corticobasal syndrome. 61
26073740 2015
32
Association of ideomotor apraxia with lesion site, etiology, neglect, and functional independence in patients with first ever stroke. 61
25936541 2015
33
Improving ideomotor limb apraxia by electrical stimulation of the left posterior parietal cortex. 61
25481002 2015
34
Oral health and apraxia among institutionalized elderly people--a pilot study. 61
25252592 2015
35
Limb apraxia and the "affordance competition hypothesis". 61
26283948 2015
36
[Aseptic meningitis in a patient with cerebrospinal fluid anti-agalactosyl IgG antibody-positive preclinical rheumatoid arthritis: a case report]. 61
26511025 2015
37
Apraxia in anti-glutamic acid decarboxylase-associated stiff person syndrome: link to corticobasal degeneration? 61
25100431 2015
38
Alien Limb Syndrome Responsive to Amantadine in a Patient with Corticobasal Syndrome. 61
26217545 2015
39
Cognitive-motor dysfunction after severe traumatic brain injury: A cerebral interhemispheric disconnection syndrome. 61
26340588 2015
40
Crossed-brain representation of verbal and nonverbal functions. 61
25802778 2015
41
Clinical Utility of Amyloid Imaging in a Complex Case of Corticobasal Syndrome Presenting with Psychiatric Symptoms. 61
26225355 2014
42
Cognitive dysfunction associated with falls in progressive supranuclear palsy. 61
25088758 2014
43
Praxis and writing in a right-hander with crossed aphasia. 61
23557340 2014
44
Nonverbal oral apraxia in primary progressive aphasia and apraxia of speech. 61
24727315 2014
45
[Functional coupling of the frontal and parietal lobes in action]. 61
24748093 2014
46
Corticobasal degeneration. 61
24963675 2014
47
Right hand predominant constructional apraxia due to right hemisphere infarction without corpus callosum lesions. 61
25030572 2014
48
[Acute disseminated encephalomyelitis following influenza vaccination: report of a case with callosal disconnection syndrome]. 61
24583588 2014
49
Callosal disconnection and limb-kinetic apraxia. 61
23972140 2014
50
Neural correlates of transitive and intransitive action imitation: an investigation using voxel-based morphometry. 61
25610762 2014

Variations for Ideomotor Apraxia

Expression for Ideomotor Apraxia

Search GEO for disease gene expression data for Ideomotor Apraxia.

Pathways for Ideomotor Apraxia

Pathways related to Ideomotor Apraxia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.74 TARDBP SNCA PSEN2 PRNP MAPT FUS
2 11.63 SNCA PSEN2 MAPT APOE
3 11.63 TARDBP SNCA PSEN2 PRNP MAPT APOE
4 11.09 PSEN2 MAPT APOE

GO Terms for Ideomotor Apraxia

Cellular components related to Ideomotor Apraxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.55 PRNP MAPT FUS C9orf72 APOE
2 neuronal cell body GO:0043025 9.35 SNCA PSEN2 MAPT FUS APOE
3 inclusion body GO:0016234 9.32 SNCA PRNP
4 main axon GO:0044304 9.26 MAPT C9orf72
5 growth cone GO:0030426 8.92 SNCA PSEN2 MAPT C9orf72

Biological processes related to Ideomotor Apraxia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron apoptotic process GO:0043524 9.61 SNCA GRN APOE
2 long-term memory GO:0007616 9.54 PRNP APOE
3 negative regulation of amyloid-beta formation GO:1902430 9.52 PRNP APOE
4 microglial cell activation GO:0001774 9.51 SNCA MAPT
5 cellular response to copper ion GO:0071280 9.49 SNCA PRNP
6 positive regulation of endocytosis GO:0045807 9.48 SNCA APOE
7 stress granule assembly GO:0034063 9.46 MAPT C9orf72
8 protein homooligomerization GO:0051260 9.43 PRNP MAPT FUS
9 regulation of neuronal synaptic plasticity GO:0048168 9.4 SNCA APOE
10 negative regulation of long-term synaptic potentiation GO:1900272 9.37 PRNP APOE
11 positive regulation of neuron death GO:1901216 9.33 SNCA PRNP MAPT
12 supramolecular fiber organization GO:0097435 9.32 SNCA MAPT
13 gene expression GO:0010467 9.13 TARDBP FUS APOE
14 negative regulation of protein phosphorylation GO:0001933 8.92 TARDBP SNCA PRNP C9orf72

Molecular functions related to Ideomotor Apraxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 9.5 PRNP MAPT GRN
2 amyloid-beta binding GO:0001540 9.43 PRNP BCHE APOE
3 identical protein binding GO:0042802 9.17 TARDBP SNCA PRNP MAPT FUS BCHE
4 lipoprotein particle binding GO:0071813 9.16 MAPT APOE
5 cuprous ion binding GO:1903136 8.96 SNCA PRNP

Sources for Ideomotor Apraxia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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