MCID: IDH005
MIFTS: 12

Idh-Wildtype Glioblastoma

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Idh-Wildtype Glioblastoma

MalaCards integrated aliases for Idh-Wildtype Glioblastoma:

Name: Idh-Wildtype Glioblastoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0080878
NCIt 50 C39750

Summaries for Idh-Wildtype Glioblastoma

Disease Ontology : 12 A glioblastoma that is characterized by high cellularity, high mitotic activity, necrosis or microvascular proliferation and that lacks mutations in IDH genes.

MalaCards based summary : Idh-Wildtype Glioblastoma is related to glioblastoma and glioma susceptibility 1. An important gene associated with Idh-Wildtype Glioblastoma is MGMT (O-6-Methylguanine-DNA Methyltransferase).

Related Diseases for Idh-Wildtype Glioblastoma

Diseases related to Idh-Wildtype Glioblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 glioblastoma 10.9
2 glioma susceptibility 1 10.4
3 malignant astrocytoma 10.4
4 glioma 10.4
5 glial tumor 10.4
6 leukemia, acute lymphoblastic 10.2
7 high grade glioma 10.2
8 demyelinating disease 10.2
9 t-cell acute lymphoblastic leukemia 10.2

Graphical network of the top 20 diseases related to Idh-Wildtype Glioblastoma:



Diseases related to Idh-Wildtype Glioblastoma

Symptoms & Phenotypes for Idh-Wildtype Glioblastoma

Drugs & Therapeutics for Idh-Wildtype Glioblastoma

Search Clinical Trials , NIH Clinical Center for Idh-Wildtype Glioblastoma

Genetic Tests for Idh-Wildtype Glioblastoma

Anatomical Context for Idh-Wildtype Glioblastoma

Publications for Idh-Wildtype Glioblastoma

Articles related to Idh-Wildtype Glioblastoma:

(show all 45)
# Title Authors PMID Year
1
Utility of methylthioadenosine phosphorylase immunohistochemical deficiency as a surrogate for CDKN2A homozygous deletion in the assessment of adult-type infiltrating astrocytoma. 61
33077924 2021
2
The Influence of Gene Aberrations on Survival in Resected IDH Wildtype Glioblastoma Patients: A Single-Institution Study. 61
33801093 2021
3
Germline ALK variations are associated with a poor prognosis in glioma and IDH-wildtype glioblastoma. 61
33486679 2021
4
Survival impact of incidental subventricular zone irradiation in IDH-wildtype glioblastoma. 61
33689536 2021
5
TERT promoter mutation: is it enough to call a WHO grade II astrocytoma IDH-wildtype glioblastoma? 61
33660766 2021
6
Targeted next-generation sequencing of adult gliomas for retrospective prognostic evaluation and up-front diagnostics. 61
32696543 2021
7
Spatiotemporal Heterogeneity in Multiparametric Physiologic MRI Is Associated with Patient Outcomes in IDH-Wildtype Glioblastoma. 61
33028594 2021
8
Age-stratified clinical performance and survival of patients with IDH-wildtype glioblastoma homogeneously treated by radiotherapy with concomitant and maintenance temozolomide. 61
32748120 2021
9
Differentiation of rare brain tumors through unsupervised machine learning: Clinical significance of in-depth methylation and copy number profiling illustrated through an unusual case of IDH wildtype glioblastoma. 61
32870144 2021
10
Intravoxel incoherent motion (IVIM) modeling of diffusion MRI during chemoradiation predicts therapeutic response in IDH wildtype glioblastoma. 61
33418005 2021
11
Beyond the World Health Organization classification of central nervous system tumors 2016: what are the new developments for gliomas from a clinician's perspective? 61
33177376 2020
12
Partial resection offers an overall survival benefit over biopsy in MGMT-unmethylated IDH-wildtype glioblastoma patients. 61
33152608 2020
13
FET PET Radiomics for Differentiating Pseudoprogression from Early Tumor Progression in Glioma Patients Post-Chemoradiation. 61
33353180 2020
14
Co-expression of cancer driver genes: IDH-wildtype glioblastoma-derived tumorspheres. 61
33317554 2020
15
The role of neuropathology in the management of newly diagnosed glioblastoma: a systematic review and evidence-based clinical practice guideline. 61
33215342 2020
16
Glioblastomas harboring gene fusions detected by next-generation sequencing. 61
32761533 2020
17
A Preliminary Study on Machine Learning-Based Evaluation of Static and Dynamic FET-PET for the Detection of Pseudoprogression in Patients with IDH-Wildtype Glioblastoma. 61
33105661 2020
18
The Multipotential of Leucine-Rich α-2 Glycoprotein 1 as a Clinicopathological Biomarker of Glioblastoma. 61
32647893 2020
19
Molecular Correlates of Long Survival in IDH-Wildtype Glioblastoma Cohorts. 61
32647886 2020
20
Increased Tau Expression Correlates With IDH Mutation in Infiltrating Gliomas and Impairs Cell Migration. 61
32181806 2020
21
Classification of Progression Patterns in Glioblastoma: Analysis of Predictive Factors and Clinical Implications. 61
33251147 2020
22
Prognostic impact of CDKN2A/B deletion, TERT mutation, and EGFR amplification on histological and molecular IDH-wildtype glioblastoma. 61
33235995 2020
23
Clinical, radiologic, and genetic characteristics of histone H3 K27M-mutant diffuse midline gliomas in adults. 61
33354667 2020
24
The Association Between the Extent of Glioblastoma Resection and Survival in Light of MGMT Promoter Methylation in 326 Patients With Newly Diagnosed IDH-Wildtype Glioblastoma. 61
32766140 2020
25
Expression of Olig2, Nestin, NogoA and AQP4 have no impact on overall survival in IDH-wildtype glioblastoma. 61
32160197 2020
26
Topographical Mapping of 436 Newly Diagnosed IDH Wildtype Glioblastoma With vs. Without MGMT Promoter Methylation. 61
32477929 2020
27
Cooperation of oncolytic virotherapy with VEGF-neutralizing antibody treatment in IDH wildtype glioblastoma depends on MMP9. 61
31412117 2019
28
Finding a four-leaf clover-identifying long-term survivors in IDH-wildtype glioblastoma. 61
31511900 2019
29
Molecular profiling of long-term IDH-wildtype glioblastoma survivors. 61
31346613 2019
30
18F-Fluoroethyl-tyrosine uptake is correlated with amino acid transport and neovascularization in treatment-naive glioblastomas. 61
31289907 2019
31
Genetic Alterations of Epidermal Growth Factor Receptor in Glioblastoma: The Usefulness of Immunohistochemistry. 61
29912767 2019
32
Programmed Death Ligand 1 Is a Negative Prognostic Marker in Recurrent Isocitrate Dehydrogenase-Wildtype Glioblastoma. 61
30011045 2019
33
Predictive MGMT status in a homogeneous cohort of IDH wildtype glioblastoma patients. 61
31167648 2019
34
Gene Expression Profiling Stratifies IDH-Wildtype Glioblastoma With Distinct Prognoses. 61
31921684 2019
35
N2M2 (NOA-20) phase I/II trial of molecularly matched targeted therapies plus radiotherapy in patients with newly diagnosed non-MGMT hypermethylated glioblastoma. 61
30277538 2019
36
The role of frameless stereotactic biopsy in contemporary neuro-oncology: molecular specifications and diagnostic yield in biopsied glioma patients. 61
30390175 2019
37
Creutzfeldt astrocytes may be seen in IDH-wildtype glioblastoma and retain expression of DNA repair and chromatin binding proteins. 61
29509313 2018
38
BRAF V600E, TERT promoter mutations and CDKN2A/B homozygous deletions are frequent in epithelioid glioblastomas: a histological and molecular analysis focusing on intratumoral heterogeneity. 61
29105198 2018
39
Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations. 61
29564591 2018
40
The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma. 61
29802247 2018
41
Multimodal molecular analysis of astroblastoma enables reclassification of most cases into more specific molecular entities. 61
28960623 2018
42
Molecular differences in IDH wildtype glioblastoma according to MGMT promoter methylation. 61
29016808 2018
43
Imaging and Histopathologic Nuances of Epithelioid Glioblastoma. 61
29951334 2018
44
Carnosine selectively inhibits migration of IDH-wildtype glioblastoma cells in a co-culture model with fibroblasts. 61
30123089 2018
45
Expression of Cathepsins B, D, and G in Isocitrate Dehydrogenase-Wildtype Glioblastoma. 61
28611989 2017

Variations for Idh-Wildtype Glioblastoma

Expression for Idh-Wildtype Glioblastoma

Search GEO for disease gene expression data for Idh-Wildtype Glioblastoma.

Pathways for Idh-Wildtype Glioblastoma

GO Terms for Idh-Wildtype Glioblastoma

Sources for Idh-Wildtype Glioblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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