Aliases & Classifications for Idiopathic Achalasia

MalaCards integrated aliases for Idiopathic Achalasia:

Name: Idiopathic Achalasia 53
Esophageal Achalasia 53 73
Achalasia 53 73
Idiopathic Achalasia of Esophagus 53
Primary Achalasia 53
Achalasia Cardia 53

Classifications:



External Ids:

SNOMED-CT via HPO 69 45564002
UMLS 73 C1321756

Summaries for Idiopathic Achalasia

NIH Rare Diseases : 53 Achalasia is a disorder of the esophagus, the tube that carries food from the mouth to the stomach. It is characterized by enlargement of the esophagus, impaired ability of the esophagus to push food down toward the stomach (peristalsis), and failure of the ring-shaped muscle at the bottom of the esophagus (the lower esophageal sphincter) to relax. Achalasia is typically diagnosed in individuals between 25 and 60 years of age. The exact etiology is unknown, however, symptoms are caused by damage to the nerves of the esophagus.Familial studies have shown evidence of a potential genetic influence. When a genetic influence is suspected, achalasia is called familial esophageal achalasia. Treatment is aimed at reducing the pressure at the lower esophageal sphincter and may include Botox, medications, or surgery.

MalaCards based summary : Idiopathic Achalasia, also known as esophageal achalasia, is related to chagas disease and achalasia, familial esophageal. An important gene associated with Idiopathic Achalasia is NOS2 (Nitric Oxide Synthase 2), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Methylene blue and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include bone and testes, and related phenotypes are achalasia and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Idiopathic Achalasia

Diseases related to Idiopathic Achalasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)
# Related Disease Score Top Affiliating Genes
1 chagas disease 30.6 IL10 NOS2 TNF
2 achalasia, familial esophageal 11.6
3 spondylarthropathy 10.7 LTA TNF
4 dystrophinopathies 10.7 NOS2 TNF
5 streptococcal toxic-shock syndrome 10.7 LTA TNF
6 crohn's colitis 10.7 NOS2 TNF
7 null-cell leukemia 10.7 LTA TNF
8 listeria meningitis 10.7 LTA TNF
9 sympathetic ophthalmia 10.7 LTA TNF
10 monoclonal gammopathy of uncertain significance 10.6 LTA TNF
11 achalasia 10.6
12 immunoglobulin a deficiency 1 10.6 IL10 LTA
13 punctate inner choroidopathy 10.6 IL10 TNF
14 tropical endomyocardial fibrosis 10.6 IL10 TNF
15 microscopic polyangiitis 10.5 IL10 TNF
16 multifocal choroiditis 10.5 IL10 TNF
17 tungiasis 10.5 IL10 TNF
18 endomyocardial fibrosis 10.5 IL10 TNF
19 mycetoma 10.5 IL10 NOS2
20 choroiditis 10.5 IL10 TNF
21 trichuriasis 10.5 IL10 TNF
22 mucocutaneous leishmaniasis 10.5 IL10 TNF
23 clonorchiasis 10.5 IL10 TNF
24 trachoma 10.5 IL10 TNF
25 listeriosis 10.5 IL10 TNF
26 transverse myelitis 10.5 IL10 TNF
27 primary systemic mycosis 10.5 IL10 TNF
28 poliomyelitis 10.5 IL10 TNF
29 intermediate uveitis 10.5 IL10 TNF
30 multidrug-resistant tuberculosis 10.5 IL10 TNF
31 orofacial granulomatosis 10.5 IL10 TNF
32 coccidiosis 10.5 IL10 TNF
33 hemorrhagic fever 10.5 IL10 TNF
34 beryllium disease 10.5 HLA-DQB1 TNF
35 autoimmune pancreatitis 10.4 HLA-DQB1 TNF
36 chronic beryllium disease 10.4 HLA-DQB1 TNF
37 spotted fever 10.4 IL10 TNF
38 lichen sclerosus 10.4 HLA-DQB1 TNF
39 hematopoietic stem cell transplantation 10.4 IL10 TNF
40 aseptic meningitis 10.4 IL10 TNF
41 scrub typhus 10.4 IL10 TNF
42 cytomegalovirus retinitis 10.4 HLA-DQB1 TNF
43 cytomegalovirus infection 10.4 IL10 TNF
44 plasmodium vivax malaria 10.4 IL10 TNF
45 q fever 10.4 IL10 TNF
46 sialadenitis 10.4 HLA-DQB1 TNF
47 lacrimal apparatus disease 10.4 IL10 TNF
48 aphthous stomatitis 10.4 IL10 TNF
49 churg-strauss syndrome 10.4 IL10 TNF
50 epstein-barr virus-associated gastric carcinoma 10.4 IL10 TNF

Graphical network of the top 20 diseases related to Idiopathic Achalasia:



Diseases related to Idiopathic Achalasia

Symptoms & Phenotypes for Idiopathic Achalasia

Human phenotypes related to Idiopathic Achalasia:

32
# Description HPO Frequency HPO Source Accession
1 achalasia 32 hallmark (90%) HP:0002571

GenomeRNAi Phenotypes related to Idiopathic Achalasia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.62 NOS2 TNF HLA-DQB1 IL10 LTA
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.62 NOS2 TNF HLA-DQB1 IL10 LTA

MGI Mouse Phenotypes related to Idiopathic Achalasia:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.09 LTA IL10 NOS2 AAAS IL23R IL33
2 digestive/alimentary MP:0005381 10.06 IL10 NOS2 AAAS IL23R IL33 HLA-DQB1
3 behavior/neurological MP:0005386 10.04 HLA-DQB1 LTA IL10 AAAS TNF VIPR1
4 cellular MP:0005384 10.02 IL33 HLA-DQB1 IL10 AAAS TNF VIPR1
5 growth/size/body region MP:0005378 10.01 LTA IL10 NOS2 AAAS IL23R HLA-DQB1
6 homeostasis/metabolism MP:0005376 9.97 LTA IL10 NOS2 AAAS IL23R IL33
7 hematopoietic system MP:0005397 9.91 LTA IL10 IL23R IL33 HLA-DQB1 NOS2
8 immune system MP:0005387 9.8 IL33 HLA-DQB1 LTA IL10 IL23R TNF
9 liver/biliary system MP:0005370 9.55 HLA-DQB1 LTA IL10 TNF NOS2
10 reproductive system MP:0005389 9.43 HLA-DQB1 IL10 AAAS IL33 NOS2 TNF
11 respiratory system MP:0005388 9.1 LTA IL10 NOS2 IL33 HLA-DQB1 TNF

Drugs & Therapeutics for Idiopathic Achalasia

Drugs for Idiopathic Achalasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 81)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylene blue Approved, Investigational Phase 4,Not Applicable 61-73-4
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3 glucocorticoids Phase 4
4 Hormone Antagonists Phase 4
5 Hormones Phase 4
6 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
7 Anti-Inflammatory Agents Phase 4
8 Antineoplastic Agents, Hormonal Phase 4
9
Ceftazidime Approved Phase 2, Phase 3 78439-06-2, 72558-82-8 5481173
10 Anesthetics Phase 3,Not Applicable
11 Anti-Bacterial Agents Phase 2, Phase 3,Not Applicable
12 Antibiotics, Antitubercular Phase 2, Phase 3,Not Applicable
13 Anti-Infective Agents Phase 2, Phase 3,Not Applicable
14 Tin Fluorides Phase 3
15 Pharmaceutical Solutions Phase 2, Phase 3,Not Applicable
16
Menthol Approved Phase 1, Phase 2,Not Applicable 2216-51-5 16666
17
Nitric Oxide Approved Phase 1, Phase 2 10102-43-9 145068 160954
18
Naloxegol Approved Phase 2 854601-70-0
19 Peripheral Nervous System Agents Phase 2,Not Applicable
20 Narcotic Antagonists Phase 2
21 Narcotics Phase 2
22 Cola Nutraceutical Phase 2
23
Salmon Calcitonin Approved, Investigational Not Applicable 47931-85-1 16129616
24
Acetylcholine Approved Not Applicable 51-84-3 187
25
Diphenhydramine Approved, Investigational Not Applicable 147-24-0, 58-73-1 3100
26
Histamine Approved, Investigational Not Applicable 75614-87-8, 51-45-6 774
27
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
28
Promethazine Approved, Investigational Not Applicable 60-87-7 4927
29
Ondansetron Approved Not Applicable 99614-02-5 4595
30
Amyl Nitrite Approved Not Applicable 8017-89-8, 463-04-7 10026
31 Mirabegron Approved Early Phase 1 223673-61-8 9865528
32
Esomeprazole Approved, Investigational Not Applicable 161796-78-7, 119141-88-7 4594 9579578
33
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
34
Domperidone Approved, Investigational, Vet_approved Not Applicable 57808-66-9 3151
35 tannic acid Approved, Nutraceutical Not Applicable
36
Calcitonin gene-related peptide Investigational Not Applicable 83652-28-2
37 calcitonin Not Applicable
38 Analgesics Not Applicable
39 Cephalosporins Not Applicable
40 Hemostatics Not Applicable
41 Anesthetics, Local Not Applicable
42 Hypnotics and Sedatives Not Applicable
43 Antitubercular Agents Not Applicable
44 Bone Density Conservation Agents Not Applicable
45
Histamine Phosphate Not Applicable 51-74-1 65513
46 abobotulinumtoxinA Not Applicable
47 Central Nervous System Depressants Not Applicable
48 Cholinergic Agents Not Applicable
49 Serotonin Agents Not Applicable
50 Serotonin Antagonists Not Applicable

Interventional clinical trials:

(show top 50) (show all 87)
# Name Status NCT ID Phase Drugs
1 Personalized Peroral Endoscopic Myotomy for Achalasia Unknown status NCT01570621 Phase 4
2 Assessing the Efficacy of Steroid Treatment of Achalasia Enrolling by invitation NCT01903486 Phase 4 Apo-Prednisone Cordorol, Detasone - Prednisone
3 Comparison of Esophageal and Anorectal Manometry Catheters Terminated NCT00204763 Phase 4
4 Peroral Endoscopic Myotomy for Primary Esophageal Achalasia Completed NCT01560559 Phase 3
5 Single- Versus Multiple-dose Antimicrobial Prophylaxis for The Prevention of Infectious Complications Associated With Peroral Endoscopic Myotomy(POEM) for Achalasia Active, not recruiting NCT03404739 Phase 2, Phase 3 Saline Solution;Ceftazidime
6 Efficacy of Dark Chocolate in Achalasia Patients Unknown status NCT00790465 Phase 1, Phase 2
7 Endolumenal Partial Myotomy for the Treatment of Esophageal Achalasia Unknown status NCT01302288 Phase 2
8 Prospective Study on the Feasibility and Effectiveness of Per-Oral Endoscopic Myotomy (P.O.E.M.) for Treatment of Primary Esophageal Motility Disorders Unknown status NCT01524458 Phase 1, Phase 2
9 Endolumenal Partial Myotomy for Esophageal Motility Disorders Unknown status NCT01302301 Phase 2
10 Per-Oral Endoscopic Myotomy (P.O.E.M.) for Treatment of Primary Esophageal Motility Disorders Unknown status NCT01524471 Phase 2
11 Prospective Study on the Feasibility and Results of POEM in Idiopathic Achalasia Completed NCT02259283 Phase 2
12 Peroral Endoscopic Myotomy (POEM) for the Treatment of Achalasia Completed NCT02073578 Phase 1, Phase 2
13 Pneumatic Dilatation or Surgical Myotomy for Achalasia Completed NCT02086669 Phase 2
14 Endoscopic Myotomy for the Treatment of Achalasia (Motility Disorder) of the Esophagus - POEM Procedure Completed NCT01873300 Phase 1, Phase 2
15 Study of IW-1701, A Stimulator of Soluble Guanylate Cyclase (sGC), in Patients With Type I or II Achalasia Recruiting NCT02931565 Phase 2 IW-1701;Matching Placebo
16 Movantik for Opioid-Related Esophageal Disorders Recruiting NCT02998606 Phase 2 Naloxegol;Placebo Oral Capsule
17 Evaluation of the Safety and Effectiveness of Tailored Transoral Incisionless Fundoplication (TIF) Using EsophyX for the Treatment of GERD Withdrawn NCT01025739 Phase 2
18 Clinical Impact of Peroral Endoscopic Myotomy for Esophageal Achalasia Unknown status NCT01649843 Not Applicable
19 Hot Water Drinking Therapy in Achalasia Unknown status NCT01863966 Not Applicable
20 Achalasia: Mechanisms Underlying Treatment Failure Unknown status NCT02055469
21 POEM Versus Pneumatic Dilatation in Achalasia Cardia Unknown status NCT02025790 Not Applicable
22 Outcome of Symptoms in Patients Undergoing a Heller Myotomy Unknown status NCT00519220
23 POEM vs. Pneumatic Dilation for Esophageal Achalasia Unknown status NCT01768091 Not Applicable
24 Comparison Study of Conventional POEM and Hybrid POEM for Esophageal Achalasia Unknown status NCT01742494 Not Applicable
25 A Randomized Comparison of Laparoscopic Myotomy and Pneumatic Dilatation for Achalasia Unknown status NCT00188344 Not Applicable
26 Bacteremia and Procalcitonin Levels in Peroral Endoscopic Myotomy for Achalasia Unknown status NCT01750385 Not Applicable no antibiotic prophylaxis;second-generation cephalosporin
27 POEM- Peroral Endoscopic Myotomy for Esophageal Motility Disorders Unknown status NCT01512719 Not Applicable
28 Peroral Endoscopic Remyotomy for Failed Heller Myotomy Unknown status NCT01637311 Not Applicable
29 Reversibility of Dysmotility After Gastric Banding Unknown status NCT00680030
30 Pyloric Sphincter Pressure and Geometry Assessment Using EndoFlip Unknown status NCT02446119
31 Functional Endoscopy in Neurogenic Dysphagia Unknown status NCT01995929
32 The Role That Peroral Endoscopic Myotomy (POEM) Could Play in the Treatment of Achalasia Completed NCT01584635 Not Applicable
33 Endoscopic Peroral Myotomy for Treatment of Achalasia Completed NCT01405469 Not Applicable
34 A Clinical Study of Per Oral Endoscopic Myotomy (POEM) in Patients Suffering From Achalasia Completed NCT01692106 Not Applicable
35 Genetic Evaluation of AAAS Gene in Early-Onset Achalasia and Alacrima Patients Completed NCT00856921
36 Peroral Endoscopic Myotomy (POEM) for Esophageal Motility Completed NCT02314741 Not Applicable
37 Evaluation of a Novel Endoscopic Treatment for Achalasia Completed NCT01770249 Not Applicable
38 A Prospective Study Comparing Two Reconstructive Operation Techniques After Myotomy of Achalasia Completed NCT01933373 Not Applicable
39 Do Patients Who Have Had Surgery for Achalasia Suffer From Reflux Completed NCT00519441 Not Applicable
40 Efficacy & Safety of Submucosal Endoscopic Myotomy With Mucosal Flap (SEMF) in the Treatment of Patients With Achalasia Completed NCT01438398 Not Applicable
41 POEM Anterior Versus Posterior Approach Completed NCT02454335 Not Applicable
42 Laparoscopic Dor Versus Toupet Fundoplication for the Treatment of Idiopathic Esophageal Achalasia Completed NCT00490750 Not Applicable
43 Randomized Study of Botulinum Toxin Type A for Achalasia Completed NCT00004416 Not Applicable botulinum toxin type A
44 Prospective Evaluation of a New Approach to Perform an Esophageal Myotomy: the Transesophageal Submucosa Approach Completed NCT02773589 Not Applicable
45 Per-Oral Endoscopic Myotomy (P.O.E.M.) for Treatment of Esophageal Motility Disorders Completed NCT01525732 Not Applicable
46 Per-Oral Endoscopic Esophagomyotomy (POEM) Completed NCT01635374 Not Applicable
47 SX ELLA Esophageal Degradable BD Stent System Completed NCT01337206 Not Applicable
48 Prevalence and Clinical Characteristics of Patients With Jackhammer Esophagus and Symptoms of Gastroesophageal Reflux Disease Completed NCT03347903
49 The Biologic Basis of Hernia Formation Completed NCT01099033
50 Reletex Versus Standard of Care Therapy for Post-Operative Nausea Control in Patients Undergoing Foregut Surgery Completed NCT01510379 Not Applicable IV ondansetron 4 mg q 6 hours for a total of 4 doses;IV promethazine 25 mg q 6 hours prn;Elixir promethazine 25 mg q 6 hours prn after discharge

Search NIH Clinical Center for Idiopathic Achalasia

Genetic Tests for Idiopathic Achalasia

Anatomical Context for Idiopathic Achalasia

MalaCards organs/tissues related to Idiopathic Achalasia:

41
Bone, Testes

Publications for Idiopathic Achalasia

Articles related to Idiopathic Achalasia:

(show top 50) (show all 166)
# Title Authors Year
1
Esophageal achalasia and pregnancy: own observations in 43 patients and a review of the literature. ( 29931525 )
2018
2
Esophagography in Patients With Esophageal Achalasia Diagnosed With High-resolution Esophageal Manometry. ( 29969858 )
2018
3
Impact of preoperative balloon dilatation on outcomes of laparoscopic surgery in young patients with esophageal achalasia. ( 29892807 )
2018
4
Screening for dysplasia with Lugol chromoendoscopy in longstanding idiopathic achalasia. ( 29748564 )
2018
5
EVALUATION OF ESOPHAGEAL ACHALASIA: FROM SYMPTOMS TO THE CHICAGO CLASSIFICATION. ( 29972404 )
2018
6
Endoscopic pyloroplasty for adult hypertrophic pyloric stenosisA associated with esophageal achalasia. ( 29905182 )
2018
7
Per-oral endoscopic myotomy for esophageal achalasia in a case of Allgrove syndrome. ( 29383495 )
2018
8
<i>Trypanosoma cruzi</i> Detection in Colombian Patients with a Diagnosis of Esophageal Achalasia. ( 29405099 )
2018
9
Esophageal achalasia: current diagnosis and treatment. ( 29804476 )
2018
10
Less invasive than minimally invasive: peroral endoscopic myotomy with a slim scope in the treatment of esophageal achalasia. ( 29452429 )
2018
11
Obstructive bronchitis and recurrent pneumonia in esophageal achalasia in a child: A CARE compliant case report. ( 29879065 )
2018
12
Novel Intra-Procedural Distensibility Measurement Accurately Predicts Immediate Outcome of Pneumatic Dilatation for Idiopathic Achalasia. ( 29206815 )
2017
13
Thoracoscopic Surgery in a Patient with Multiple Esophageal Carcinomas after Surgery for Esophageal Achalasia. ( 28951795 )
2017
14
Allele-specific transcriptional activity of the variable number of tandem repeats of the inducible nitric oxide synthase gene is associated with idiopathic achalasia. ( 28344787 )
2017
15
Laparoscopic esophageal myotomy versus pneumatic dilation in the treatment of idiopathic achalasia: a meta-analysis of randomized controlled trials. ( 29026325 )
2017
16
Esophageal achalasia: a risk factor for carcinoma. A systematic review and meta-analysis. ( 28859394 )
2017
17
Comprehensive epidemiological and genotype-phenotype analyses in a large European sample with idiopathic achalasia. ( 26882171 )
2016
18
Clinical response to peroral endoscopic myotomy in patients with idiopathic achalasia at a minimum follow-up of 2a88years. ( 25934759 )
2016
19
Effects of laparoscopic myotomy on the esophageal motility pattern of esophageal achalasia as measured by high-resolution manometry. ( 28039638 )
2016
20
Gene expression of muscular and neuronal pathways is cooperatively dysregulated in patients with idiopathic achalasia. ( 27511445 )
2016
21
Gender differences in both the pathology and surgical outcome of patients with esophageal achalasia. ( 27129544 )
2016
22
Tracheomalacia Due to Esophageal Achalasia. ( 27364977 )
2016
23
Diagnosis and management of esophageal achalasia. ( 27625387 )
2016
24
Laparoscopic Heller Myotomy and Dor Fundoplication for Esophageal Achalasia: Technique and Perioperative Management. ( 27606723 )
2016
25
Etiology and Pathogenesis of Idiopathic Achalasia. ( 28009686 )
2016
26
Prevalence of gallstones in 1,229 patients submitted to surgical laparoscopic treatment of GERD and esophageal achalasia: associated cholecystectomy was a safe procedure. ( 26176247 )
2015
27
Treatment of Idiopathic Achalasia in the Pediatric Population: A Systematic Review. ( 25643252 )
2015
28
Data analyses and perspectives on laparoscopic surgery for esophageal achalasia. ( 26478674 )
2015
29
Safety and efficacy of botulinum toxin injection therapy for esophageal achalasia in Japan. ( 26566311 )
2015
30
Ethanolamine oleate versus botulinum toxin in the treatment of idiopathic achalasia. ( 25830939 )
2015
31
The Impact of Heller Myotomy on Integrated Relaxation Pressure in Esophageal Achalasia. ( 26519153 )
2015
32
Hydraulic dilation with a shape-measuring balloon in idiopathic achalasia: a feasibility study. ( 26349065 )
2015
33
Treatment of esophageal achalasia in children: Today and tomorrow. ( 25783358 )
2015
34
Clinical remission following endoscopic placement of retrievable, fully covered metal stents in patients with esophageal achalasia. ( 23796127 )
2014
35
Impact of genetic polymorphisms on the pathogenesis of idiopathic achalasia: Association with IL33 gene variant. ( 24468584 )
2014
36
Per-oral endoscopic myotomy (POEM) for esophageal achalasia. ( 24362953 )
2014
37
Peroral Endoscopic Myotomy for Esophageal Achalasia: Outcomes of the First 100 Patients With Short-term Follow-up. ( 25361224 )
2014
38
Successful peroral endoscopic myotomy for radical treatment of sigmoid-type esophageal achalasia by Greek gastroenterologists. ( 25331209 )
2014
39
Peroral endoscopic myotomy for esophageal achalasia: Clinical impact of 28 cases. ( 23581563 )
2014
40
Laparoscopic heller myotomy can be used as primary therapy for esophageal achalasia regardless of age. ( 24018591 )
2014
41
Peroral endoscopic myotomy for esophageal achalasia. ( 25333007 )
2014
42
Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia. ( 24997987 )
2014
43
Laparoscopic Heller's myotomy versus pneumatic dilation in the treatment of idiopathic achalasia: a meta-analysis of randomized, controlled trials. ( 23684149 )
2013
44
Ethanolamine oleate as a novel therapy is effective in resistant idiopathic achalasia. ( 23927485 )
2013
45
Genetic variation in the lymphotoxin-I+ (LTA)/tumour necrosis factor-I+ (TNFI+) locus as a risk factor for idiopathic achalasia. ( 24259423 )
2013
46
Peroral endoscopic myotomy for idiopathic achalasia: randomized comparison of water-jet assisted versus conventional dissection technique. ( 24232052 )
2013
47
Comparison of idiopathic achalasia and Chagas' disease esophagopathy at the light of high-resolution manometry. ( 23795824 )
2013
48
Anesthetic management of peroral endoscopic myotomy for esophageal achalasia: a retrospective case series. ( 24185834 )
2013
49
Circulating antimyenteric autoantibodies in Tunisian patients with idiopathic achalasia. ( 22947106 )
2013
50
Single incision laparoscopic approach for esophageal achalasia: A case report. ( 23088902 )
2013

Variations for Idiopathic Achalasia

Expression for Idiopathic Achalasia

Search GEO for disease gene expression data for Idiopathic Achalasia.

Pathways for Idiopathic Achalasia

Pathways related to Idiopathic Achalasia according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.71 AAAS HLA-DQB1 IL10 IL23R IL33 LTA
2
Show member pathways
13.39 IL10 IL23R IL33 LTA NOS2 TNF
3
Show member pathways
12.67 AAAS HLA-DQB1 IL10 IL23R IL33 LTA
4
Show member pathways
12.63 HLA-DQB1 IL10 LTA TNF
5
Show member pathways
12.51 HLA-DQB1 IL33 LTA TNF
6
Show member pathways
12.35 IL10 IL23R LTA TNF
7
Show member pathways
12.33 IL10 IL23R NOS2 TNF
8 12.19 HLA-DQB1 LTA TNF
9
Show member pathways
12.13 HLA-DQB1 IL10 IL23R TNF
10
Show member pathways
11.97 IL33 NOS2 TNF
11
Show member pathways
11.94 IL10 IL23R LTA TNF
12 11.92 IL10 TNF VIPR1
13
Show member pathways
11.89 HLA-DQB1 IL10 NOS2 TNF
14 11.81 HLA-DQB1 IL10 NOS2 TNF
15 11.64 IL10 NOS2 TNF
16 11.51 IL10 IL23R NOS2 TNF
17 11.49 IL10 NOS2 TNF
18 11.15 IL10 TNF
19 11.14 IL10 TNF
20 11.09 IL33 TNF
21 11.04 IL10 TNF
22 10.97 IL10 LTA
23 10.92 IL10 IL23R IL33 LTA TNF

GO Terms for Idiopathic Achalasia

Biological processes related to Idiopathic Achalasia according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.86 HLA-DQB1 IL10 LTA TNF
2 regulation of signaling receptor activity GO:0010469 9.84 IL10 IL33 LTA TNF
3 inflammatory response GO:0006954 9.81 IL10 IL23R NOS2 TNF
4 defense response to bacterium GO:0042742 9.78 IL10 NOS2 TNF
5 cytokine-mediated signaling pathway GO:0019221 9.78 IL10 IL23R NOS2 TNF
6 cellular response to lipopolysaccharide GO:0071222 9.72 IL10 NOS2 TNF
7 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.62 IL10 TNF
8 response to lipopolysaccharide GO:0032496 9.62 IL10 IL23R LTA NOS2
9 negative regulation of mitotic cell cycle GO:0045930 9.61 IL10 TNF
10 positive regulation of cytokine production GO:0001819 9.6 IL33 TNF
11 positive regulation of cytokine secretion GO:0050715 9.59 IL10 TNF
12 negative regulation of interleukin-6 production GO:0032715 9.58 IL10 TNF
13 negative regulation of interferon-gamma production GO:0032689 9.58 IL10 IL33
14 positive regulation of osteoclast differentiation GO:0045672 9.57 IL23R TNF
15 positive regulation of macrophage activation GO:0043032 9.52 IL10 IL33
16 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.49 IL10 TNF
17 endothelial cell apoptotic process GO:0072577 9.46 IL10 TNF
18 negative regulation of cytokine secretion involved in immune response GO:0002740 9.43 IL10 TNF
19 type 2 immune response GO:0042092 9.4 IL10 IL33
20 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.37 LTA TNF
21 positive regulation of interferon-gamma production GO:0032729 9.33 IL23R LTA TNF
22 receptor biosynthetic process GO:0032800 9.26 IL10 TNF
23 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 8.96 LTA TNF
24 negative regulation of growth of symbiont in host GO:0044130 8.8 IL10 LTA TNF

Molecular functions related to Idiopathic Achalasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.96 LTA TNF
2 cytokine activity GO:0005125 8.92 IL10 IL33 LTA TNF

Sources for Idiopathic Achalasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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