Aliases & Classifications for Idiopathic Achalasia

MalaCards integrated aliases for Idiopathic Achalasia:

Name: Idiopathic Achalasia 53
Esophageal Achalasia 53 73
Achalasia 53 73
Idiopathic Achalasia of Esophagus 53
Primary Achalasia 53
Achalasia Cardia 53

Classifications:



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SNOMED-CT via HPO 69 45564002

Summaries for Idiopathic Achalasia

NIH Rare Diseases : 53 Achalasia is a disorder of the esophagus, the tube that carries food from the mouth to the stomach. It is characterized by enlargement of the esophagus, impaired ability of the esophagus to push food down toward the stomach (peristalsis), and failure of the ring-shaped muscle at the bottom of the esophagus (the lower esophageal sphincter) to relax. Achalasia is typically diagnosed in individuals between 25 and 60 years of age. The exact etiology is unknown, however, symptoms are caused by damage to the nerves of the esophagus.Familial studies have shown evidence of a potential genetic influence. When a genetic influence is suspected, achalasia is called familial esophageal achalasia. Treatment is aimed at reducing the pressure at the lower esophageal sphincter and may include Botox, medications, or surgery.

MalaCards based summary : Idiopathic Achalasia, also known as esophageal achalasia, is related to chagas disease and keratoconjunctivitis sicca. An important gene associated with Idiopathic Achalasia is AAAS (Aladin WD Repeat Nucleoporin), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Methylene blue and Acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and lymph node, and related phenotypes are achalasia and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Idiopathic Achalasia

Diseases related to Idiopathic Achalasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 274)
# Related Disease Score Top Affiliating Genes
1 chagas disease 30.3 IL10 NOS2 TNF
2 keratoconjunctivitis sicca 29.5 IL10 TNF
3 arthritis 29.1 HLA-DQB1 IL10 LTA TNF
4 autoimmune disease 29.1 HLA-DQB1 IL10 LTA TNF
5 achalasia-addisonianism-alacrima syndrome 12.8
6 achalasia-microcephaly syndrome 12.5
7 alacrima, achalasia, and mental retardation syndrome 12.5
8 moyamoya disease 6 with or without achalasia 12.4
9 deafness, congenital, with vitiligo and achalasia 12.4
10 mental retardation, x-linked, syndromic 17 12.0
11 hirschsprung disease 1 11.3
12 jackhammer esophagus 11.3
13 achalasia, familial esophageal 11.3
14 sjogren syndrome 11.3
15 posterior column ataxia with retinitis pigmentosa 11.0
16 muscular dystrophy, limb-girdle, autosomal recessive 18 11.0
17 gmppa-cdg 11.0
18 achalasia 10.8
19 dysphagia 10.4
20 gastroesophageal reflux 10.3
21 peanut allergy 10.2 HLA-DQB1 IL10
22 acute disseminated encephalomyelitis 10.2 HLA-DQB1 IL10
23 esophageal cancer 10.2
24 adenocarcinoma 10.2
25 dyskinesia of esophagus 10.2
26 pneumonia 10.2
27 degos 'en cocarde' erythrokeratoderma 10.2
28 buruli ulcer 10.1 IL10 LOC111365141
29 mycetoma 10.1 IL10 NOS2
30 squamous cell carcinoma 10.1
31 nasal cavity disease 10.1 IL10 IL33
32 hernia, hiatus 10.1
33 esophageal varix 10.1
34 neuropathy 10.1
35 familial glucocorticoid deficiency 10.1
36 mycobacterium fortuitum 10.1
37 transient hypogammaglobulinemia of infancy 10.1 IL10 LTA
38 punctate inner choroidopathy 10.1 IL10 TNF
39 beryllium disease 10.0 HLA-DQB1 TNF
40 tropical endomyocardial fibrosis 10.0 IL10 TNF
41 down syndrome 10.0
42 endomyocardial fibrosis 10.0 IL10 TNF
43 chronic beryllium disease 10.0 HLA-DQB1 TNF
44 cardiac sarcoidosis 10.0 HLA-DQB1 TNF
45 microscopic polyangiitis 10.0 IL10 TNF
46 multifocal choroiditis 10.0 IL10 TNF
47 choroiditis 10.0 IL10 TNF
48 tungiasis 10.0 IL10 TNF
49 microscopic colitis 10.0 HLA-DQB1 TNF
50 cow milk allergy 10.0 IL10 TNF

Graphical network of the top 20 diseases related to Idiopathic Achalasia:



Diseases related to Idiopathic Achalasia

Symptoms & Phenotypes for Idiopathic Achalasia

Human phenotypes related to Idiopathic Achalasia:

32
# Description HPO Frequency HPO Source Accession
1 achalasia 32 hallmark (90%) HP:0002571

GenomeRNAi Phenotypes related to Idiopathic Achalasia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.62 HLA-DQB1 IL10 LTA NOS2 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.62 HLA-DQB1 IL10 LTA NOS2 TNF

MGI Mouse Phenotypes related to Idiopathic Achalasia:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.09 AAAS HLA-DQB1 IL10 IL23R IL33 LTA
2 digestive/alimentary MP:0005381 10.06 AAAS HLA-DQB1 IL10 IL23R IL33 NOS2
3 behavior/neurological MP:0005386 10.04 AAAS HLA-DQB1 IL10 LTA NOS2 TNF
4 cellular MP:0005384 10.02 AAAS HLA-DQB1 IL10 IL33 NOS2 TNF
5 growth/size/body region MP:0005378 10.01 AAAS HLA-DQB1 IL10 IL23R LTA NOS2
6 homeostasis/metabolism MP:0005376 9.97 AAAS HLA-DQB1 IL10 IL23R IL33 LTA
7 hematopoietic system MP:0005397 9.91 HLA-DQB1 IL10 IL23R IL33 LTA NOS2
8 immune system MP:0005387 9.8 HLA-DQB1 IL10 IL23R IL33 LTA NOS2
9 liver/biliary system MP:0005370 9.55 HLA-DQB1 IL10 LTA NOS2 TNF
10 reproductive system MP:0005389 9.43 AAAS HLA-DQB1 IL10 IL33 NOS2 TNF
11 respiratory system MP:0005388 9.1 HLA-DQB1 IL10 IL33 LTA NOS2 TNF

Drugs & Therapeutics for Idiopathic Achalasia

Drugs for Idiopathic Achalasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 83)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylene blue Approved, Investigational Phase 4,Not Applicable 61-73-4
2
Acetylcholine Approved Phase 4,Not Applicable 51-84-3 187
3
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
4 Acetylcholine Release Inhibitors Phase 4,Not Applicable
5 onabotulinumtoxinA Phase 4,Not Applicable
6 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
7 Cholinergic Agents Phase 4,Not Applicable
8 abobotulinumtoxinA Phase 4,Not Applicable
9 Neurotransmitter Agents Phase 4,Not Applicable,Early Phase 1
10 Neuromuscular Agents Phase 4,Not Applicable
11 Botulinum Toxins Phase 4,Not Applicable
12 Botulinum Toxins, Type A Phase 4,Not Applicable
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
14 Antineoplastic Agents, Hormonal Phase 4
15 Hormone Antagonists Phase 4
16 glucocorticoids Phase 4
17 Hormones Phase 4
18 Anti-Inflammatory Agents Phase 4
19
Ceftazidime Approved Phase 2, Phase 3 78439-06-2, 72558-82-8 5481173
20 Anesthetics Phase 3,Not Applicable
21 Anti-Bacterial Agents Phase 2, Phase 3,Not Applicable
22 Anti-Infective Agents Phase 2, Phase 3,Not Applicable
23 Antibiotics, Antitubercular Phase 2, Phase 3,Not Applicable
24 Tin Fluorides Phase 3
25 Pharmaceutical Solutions Phase 2, Phase 3,Not Applicable
26
Nitric Oxide Approved Phase 1, Phase 2 10102-43-9 145068
27
Naloxegol Approved Phase 2 854601-70-0
28 Cola Phase 2
29 Narcotic Antagonists Phase 2
30 Narcotics Phase 2
31 Analgesics, Opioid Phase 2
32
Salmon Calcitonin Approved, Investigational Not Applicable 47931-85-1 16129616
33
Amyl Nitrite Approved Not Applicable 463-04-7, 8017-89-8 10026
34
Histamine Approved, Investigational Not Applicable 51-45-6, 75614-87-8 774
35
Promethazine Approved, Investigational Not Applicable 60-87-7 4927
36
Ondansetron Approved Not Applicable 99614-02-5 4595
37
Diphenhydramine Approved, Investigational Not Applicable 147-24-0, 58-73-1 3100
38 tannic acid Approved Not Applicable
39
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
40 Mirabegron Approved Early Phase 1 223673-61-8
41
Ropivacaine Approved Not Applicable 84057-95-4 175805 71273
42
Domperidone Approved, Investigational, Vet_approved Not Applicable 57808-66-9 3151
43
Esomeprazole Approved, Investigational Not Applicable 161796-78-7, 119141-88-7 4594 9579578
44
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
45
Calcitonin gene-related peptide Investigational Not Applicable 83652-28-2
46 Hemostatics Not Applicable
47 Anesthetics, Local Not Applicable
48 Hypnotics and Sedatives Not Applicable
49 Analgesics Not Applicable
50 Cephalosporins Not Applicable

Interventional clinical trials:

(show top 50) (show all 94)
# Name Status NCT ID Phase Drugs
1 Personalized Peroral Endoscopic Myotomy for Achalasia Unknown status NCT01570621 Phase 4
2 Botox or Botox With Esophageal Dilation in Patients With Achalasia Enrolling by invitation NCT03654066 Phase 4 Botulinum toxin type A
3 Assessing the Efficacy of Steroid Treatment of Achalasia Enrolling by invitation NCT01903486 Phase 4 Apo-Prednisone Cordorol, Detasone - Prednisone
4 Comparison of Esophageal and Anorectal Manometry Catheters Terminated NCT00204763 Phase 4
5 Peroral Endoscopic Myotomy for Primary Esophageal Achalasia Completed NCT01560559 Phase 3
6 Single-Versus Multiple-dose Antimicrobial Prophylaxis for Peroral Endoscopic Myotomy in Achalasia Recruiting NCT03784365 Phase 3 3Rd Generation Cephalosporins
7 Single- Versus Multiple-dose Antimicrobial Prophylaxis for The Prevention of Infectious Complications Associated With Peroral Endoscopic Myotomy(POEM) for Achalasia Active, not recruiting NCT03404739 Phase 2, Phase 3 Saline Solution;Ceftazidime
8 Efficacy of Dark Chocolate in Achalasia Patients Unknown status NCT00790465 Phase 1, Phase 2
9 Endolumenal Partial Myotomy for the Treatment of Esophageal Achalasia Unknown status NCT01302288 Phase 2
10 Prospective Study on the Feasibility and Effectiveness of Per-Oral Endoscopic Myotomy (P.O.E.M.) for Treatment of Primary Esophageal Motility Disorders Unknown status NCT01524458 Phase 1, Phase 2
11 Endolumenal Partial Myotomy for Esophageal Motility Disorders Unknown status NCT01302301 Phase 2
12 Per-Oral Endoscopic Myotomy (P.O.E.M.) for Treatment of Primary Esophageal Motility Disorders Unknown status NCT01524471 Phase 2
13 Prospective Study on the Feasibility and Results of POEM in Idiopathic Achalasia Completed NCT02259283 Phase 2
14 Peroral Endoscopic Myotomy (POEM) for the Treatment of Achalasia Completed NCT02073578 Phase 1, Phase 2
15 Pneumatic Dilatation or Surgical Myotomy for Achalasia Completed NCT02086669 Phase 2
16 Study of IW-1701, A Stimulator of Soluble Guanylate Cyclase (sGC), in Patients With Type I or II Achalasia Completed NCT02931565 Phase 2 IW-1701;Matching Placebo
17 Endoscopic Myotomy for the Treatment of Achalasia (Motility Disorder) of the Esophagus - POEM Procedure Completed NCT01873300 Phase 1, Phase 2
18 Movantik for Opioid-Related Esophageal Disorders Terminated NCT02998606 Phase 2 Naloxegol;Placebo Oral Capsule
19 Evaluation of the Safety and Effectiveness of Tailored Transoral Incisionless Fundoplication (TIF) Using EsophyX for the Treatment of GERD Withdrawn NCT01025739 Phase 2
20 Clinical Impact of Peroral Endoscopic Myotomy for Esophageal Achalasia Unknown status NCT01649843 Not Applicable
21 Hot Water Drinking Therapy in Achalasia Unknown status NCT01863966 Not Applicable
22 Achalasia: Mechanisms Underlying Treatment Failure Unknown status NCT02055469
23 POEM Versus Pneumatic Dilatation in Achalasia Cardia Unknown status NCT02025790 Not Applicable
24 Outcome of Symptoms in Patients Undergoing a Heller Myotomy Unknown status NCT00519220
25 POEM vs. Pneumatic Dilation for Esophageal Achalasia Unknown status NCT01768091 Not Applicable
26 Snare-assisted POEM for Treatment of Esophageal Achalasia Unknown status NCT02999451 Not Applicable
27 Comparison Study of Conventional POEM and Hybrid POEM for Esophageal Achalasia Unknown status NCT01742494 Not Applicable
28 A Randomized Comparison of Laparoscopic Myotomy and Pneumatic Dilatation for Achalasia Unknown status NCT00188344 Not Applicable
29 Bacteremia and Procalcitonin Levels in Peroral Endoscopic Myotomy for Achalasia Unknown status NCT01750385 Not Applicable no antibiotic prophylaxis;second-generation cephalosporin
30 POEM- Peroral Endoscopic Myotomy for Esophageal Motility Disorders Unknown status NCT01512719 Not Applicable
31 POEM for Spastic Esophageal Disorders Unknown status NCT02425033 Not Applicable
32 Peroral Endoscopic Remyotomy for Failed Heller Myotomy Unknown status NCT01637311 Not Applicable
33 To Assess the Feasibility of Same Day Discharge Following a POEM Procedure Unknown status NCT02572193 Not Applicable
34 Clinical Outcomes of Peroral Endoscopic Myotomy Unknown status NCT02989883 Not Applicable
35 Reversibility of Dysmotility After Gastric Banding Unknown status NCT00680030
36 Pyloric Sphincter Pressure and Geometry Assessment Using EndoFlip Unknown status NCT02446119
37 Functional Endoscopy in Neurogenic Dysphagia Unknown status NCT01995929
38 The Role That Peroral Endoscopic Myotomy (POEM) Could Play in the Treatment of Achalasia Completed NCT01584635 Not Applicable
39 Endoscopic Peroral Myotomy for Treatment of Achalasia Completed NCT01405469 Not Applicable
40 Prospective Study to Assess the Diagnostic Utility of Amyl Nitrite in Patients With Suspected Achalasia Undergoing High Resolution Esophageal Manometry (HREM) Completed NCT02428959 Not Applicable Amyl Nitrite
41 A Clinical Study of Per Oral Endoscopic Myotomy (POEM) in Patients Suffering From Achalasia Completed NCT01692106 Not Applicable
42 Genetic Evaluation of AAAS Gene in Early-Onset Achalasia and Alacrima Patients Completed NCT00856921
43 Peroral Endoscopic Myotomy (POEM) for Esophageal Motility Completed NCT02314741 Not Applicable
44 Evaluation of a Novel Endoscopic Treatment for Achalasia Completed NCT01770249 Not Applicable
45 A Prospective Study Comparing Two Reconstructive Operation Techniques After Myotomy of Achalasia Completed NCT01933373 Not Applicable
46 Do Patients Who Have Had Surgery for Achalasia Suffer From Reflux Completed NCT00519441 Not Applicable
47 Efficacy & Safety of Submucosal Endoscopic Myotomy With Mucosal Flap (SEMF) in the Treatment of Patients With Achalasia Completed NCT01438398 Not Applicable
48 POEM Anterior Versus Posterior Approach Completed NCT02454335 Not Applicable
49 Laparoscopic Dor Versus Toupet Fundoplication for the Treatment of Idiopathic Esophageal Achalasia Completed NCT00490750 Not Applicable
50 Randomized Study of Botulinum Toxin Type A for Achalasia Completed NCT00004416 Not Applicable botulinum toxin type A

Search NIH Clinical Center for Idiopathic Achalasia

Genetic Tests for Idiopathic Achalasia

Anatomical Context for Idiopathic Achalasia

MalaCards organs/tissues related to Idiopathic Achalasia:

41
Heart, Lung, Lymph Node, Eye, Spinal Cord, Tonsil, Prostate

Publications for Idiopathic Achalasia

Articles related to Idiopathic Achalasia:

(show top 50) (show all 354)
# Title Authors Year
1
Esophageal achalasia and pregnancy: own observations in 43 patients and a review of the literature. ( 29931525 )
2018
2
Esophagography in Patients With Esophageal Achalasia Diagnosed With High-resolution Esophageal Manometry. ( 29969858 )
2018
3
Impact of preoperative balloon dilatation on outcomes of laparoscopic surgery in young patients with esophageal achalasia. ( 29892807 )
2018
4
Screening for dysplasia with Lugol chromoendoscopy in longstanding idiopathic achalasia. ( 29748564 )
2018
5
EVALUATION OF ESOPHAGEAL ACHALASIA: FROM SYMPTOMS TO THE CHICAGO CLASSIFICATION. ( 29972404 )
2018
6
Endoscopic pyloroplasty for adult hypertrophic pyloric stenosisA associated with esophageal achalasia. ( 29905182 )
2018
7
Per-oral endoscopic myotomy for esophageal achalasia in a case of Allgrove syndrome. ( 29383495 )
2018
8
<i>Trypanosoma cruzi</i> Detection in Colombian Patients with a Diagnosis of Esophageal Achalasia. ( 29405099 )
2018
9
Esophageal achalasia: current diagnosis and treatment. ( 29804476 )
2018
10
Less invasive than minimally invasive: peroral endoscopic myotomy with a slim scope in the treatment of esophageal achalasia. ( 29452429 )
2018
11
Obstructive bronchitis and recurrent pneumonia in esophageal achalasia in a child: A CARE compliant case report. ( 29879065 )
2018
12
A Thousand and One Laparoscopic Heller Myotomies for Esophageal Achalasia: a 25-Year Experience at a Single Tertiary Center. ( 30238248 )
2018
13
Heller myotomy is the optimal index procedure for esophageal achalasia in adolescents and young adults. ( 30552502 )
2018
14
Outcomes of per-oral endoscopic myotomy for treatment of esophageal achalasia with a median follow-up of 49 months. ( 29108981 )
2018
15
Association of Surgical Volume With Perioperative Outcomes for Esophagomyotomy for Esophageal Achalasia. ( 29261823 )
2018
16
Budd-Chiari Syndrome and Esophageal Achalasia: Unrecognized Intrahepatic Cholangiocarcinoma Invading Multiple Organs. ( 29526953 )
2018
17
Modern management of esophageal achalasia: From pathophysiology to treatment. ( 29548347 )
2018
18
Esophageal Achalasia: Pathophysiology, Clinical Presentation, and Diagnostic Evaluation. ( 29712590 )
2018
19
Endoscopic Pneumatic Dilation for Esophageal Achalasia. ( 29712591 )
2018
20
Laparoscopic Heller Myotomy versus Per Oral Endoscopic Myotomy: Evidence-Based Approach to the Treatment of Esophageal Achalasia. ( 29712595 )
2018
21
Steerable esophageal thermometer for atrial fibrillation ablation in a patient with esophageal achalasia: a case report. ( 29744068 )
2018
22
The influence of hospital volume upon clinical management and outcomes of esophageal achalasia: an English national population-based cohort study. ( 29985997 )
2018
23
New endoscopic finding of esophageal achalasia with ST Hood short type: Corona appearance. ( 30063701 )
2018
24
Finger-guided Heller cardiomyotomy procedure to prevent the recurrence of esophageal achalasia in patients who are not qualified for laparoscopy: A case series. ( 30071375 )
2018
25
An original Eurasian haplotype, HLA-DRB1*14:54-DQB1*05:03, influences the susceptibility to idiopathic achalasia. ( 30092016 )
2018
26
Novel Intra-Procedural Distensibility Measurement Accurately Predicts Immediate Outcome of Pneumatic Dilatation for Idiopathic Achalasia. ( 29206815 )
2017
27
Thoracoscopic Surgery in a Patient with Multiple Esophageal Carcinomas after Surgery for Esophageal Achalasia. ( 28951795 )
2017
28
Allele-specific transcriptional activity of the variable number of tandem repeats of the inducible nitric oxide synthase gene is associated with idiopathic achalasia. ( 28344787 )
2017
29
Laparoscopic esophageal myotomy versus pneumatic dilation in the treatment of idiopathic achalasia: a meta-analysis of randomized controlled trials. ( 29026325 )
2017
30
Esophageal achalasia: a risk factor for carcinoma. A systematic review and meta-analysis. ( 28859394 )
2017
31
Analysis of the learning curve for peroral endoscopic myotomy for esophageal achalasia: Single-center, two-operator experience. ( 27859721 )
2017
32
Etiology and Pathogenesis of Idiopathic Achalasia. ( 28009686 )
2017
33
Multidisciplinary Approach to Esophageal Achalasia: A Single Center Experience. ( 28099056 )
2017
34
Anesthetic considerations for patients with esophageal achalasia undergoing peroral endoscopic myotomy: a retrospective case series review. ( 28116675 )
2017
35
Successful peroral endoscopic myotomy performed in Endoscopy Department as a radical, long-term treatment for esophageal achalasia - the Greek experience. ( 28243108 )
2017
36
Impact of esophageal flexion level on the surgical outcome in patients with sigmoid esophageal achalasia. ( 28382500 )
2017
37
Esophageal Achalasia: Predictive Value of Preoperative Resting Pressure of LES Correlated with Type of Fundoplication. ( 28416923 )
2017
38
Patients with esophageal achalasia: Keeping them safe. ( 28445340 )
2017
39
Long-term outcome of peroral endoscopic myotomy for esophageal achalasia in patients with previous Heller myotomy. ( 27699518 )
2017
40
Comprehensive epidemiological and genotype-phenotype analyses in a large European sample with idiopathic achalasia. ( 26882171 )
2016
41
Clinical response to peroral endoscopic myotomy in patients with idiopathic achalasia at a minimum follow-up of 2a88years. ( 25934759 )
2016
42
Effects of laparoscopic myotomy on the esophageal motility pattern of esophageal achalasia as measured by high-resolution manometry. ( 28039638 )
2016
43
Gene expression of muscular and neuronal pathways is cooperatively dysregulated in patients with idiopathic achalasia. ( 27511445 )
2016
44
Gender differences in both the pathology and surgical outcome of patients with esophageal achalasia. ( 27129544 )
2016
45
Tracheomalacia Due to Esophageal Achalasia. ( 27364977 )
2016
46
Diagnosis and management of esophageal achalasia. ( 27625387 )
2016
47
Laparoscopic Heller Myotomy and Dor Fundoplication for Esophageal Achalasia: Technique and Perioperative Management. ( 27606723 )
2016
48
Laparoscopic surgery for esophageal achalasia: Multiport vs single-incision approach. ( 26315292 )
2016
49
Endoscopic treatment of esophageal achalasia. ( 26839644 )
2016
50
Laparoscopic Heller Myotomy for Non-Dilated Esophageal Achalasia in Children with Intraoperative Stepped Dilation Under Image Guidance: Attempting Complete Myotomy. ( 26845662 )
2016

Variations for Idiopathic Achalasia

Expression for Idiopathic Achalasia

Search GEO for disease gene expression data for Idiopathic Achalasia.

Pathways for Idiopathic Achalasia

Pathways related to Idiopathic Achalasia according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.71 AAAS HLA-DQB1 IL10 IL23R IL33 LTA
2
Show member pathways
13.4 IL10 IL23R IL33 LTA NOS2 TNF
3
Show member pathways
12.67 AAAS HLA-DQB1 IL10 IL23R IL33 LTA
4
Show member pathways
12.63 HLA-DQB1 IL10 LTA TNF
5
Show member pathways
12.51 HLA-DQB1 IL33 LTA TNF
6
Show member pathways
12.33 HLA-DQB1 IL10 IL23R TNF
7
Show member pathways
12.29 IL10 IL23R NOS2 TNF
8 12.2 HLA-DQB1 LTA TNF
9
Show member pathways
11.97 IL33 NOS2 TNF
10
Show member pathways
11.94 HLA-DQB1 IL10 NOS2 TNF
11 11.92 IL10 TNF VIPR1
12 11.88 HLA-DQB1 IL10 NOS2 TNF
13
Show member pathways
11.67 IL10 IL23R LTA TNF
14 11.64 IL10 NOS2 TNF
15 11.51 IL10 IL23R NOS2 TNF
16 11.49 IL10 NOS2 TNF
17 11.43 IL10 NOS2 TNF
18 11.16 IL10 TNF
19 11.15 IL10 TNF
20 11.1 IL33 TNF
21 11.04 IL10 TNF
22 10.98 IL10 LTA
23 10.96 IL10 LTA TNF
24 10.92 IL10 IL23R IL33 LTA TNF

GO Terms for Idiopathic Achalasia

Biological processes related to Idiopathic Achalasia according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.86 HLA-DQB1 IL10 LTA TNF
2 regulation of signaling receptor activity GO:0010469 9.83 IL10 IL33 LTA TNF
3 defense response to bacterium GO:0042742 9.79 IL10 NOS2 TNF
4 cytokine-mediated signaling pathway GO:0019221 9.76 IL10 IL23R NOS2 TNF
5 cellular response to lipopolysaccharide GO:0071222 9.75 IL10 NOS2 TNF
6 negative regulation of mitotic cell cycle GO:0045930 9.61 IL10 TNF
7 negative regulation of interferon-gamma production GO:0032689 9.61 IL10 IL33
8 negative regulation of interleukin-6 production GO:0032715 9.6 IL10 TNF
9 positive regulation of cytokine secretion GO:0050715 9.59 IL10 TNF
10 regulation of synapse organization GO:0050807 9.58 IL10 TNF
11 positive regulation of osteoclast differentiation GO:0045672 9.57 IL23R TNF
12 positive regulation of glial cell proliferation GO:0060252 9.55 LTA TNF
13 positive regulation of macrophage activation GO:0043032 9.54 IL10 IL33
14 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.51 IL10 TNF
15 positive regulation of interferon-gamma production GO:0032729 9.5 IL23R LTA TNF
16 positive regulation of chemokine secretion GO:0090197 9.49 IL33 TNF
17 endothelial cell apoptotic process GO:0072577 9.48 IL10 TNF
18 response to lipopolysaccharide GO:0032496 9.46 IL10 IL23R LTA NOS2
19 negative regulation of cytokine secretion involved in immune response GO:0002740 9.43 IL10 TNF
20 positive regulation of neuroinflammatory response GO:0150078 9.4 IL33 TNF
21 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.37 LTA TNF
22 receptor biosynthetic process GO:0032800 9.26 IL10 TNF
23 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 8.96 LTA TNF
24 negative regulation of growth of symbiont in host GO:0044130 8.8 IL10 LTA TNF

Molecular functions related to Idiopathic Achalasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.96 LTA TNF
2 cytokine activity GO:0005125 8.92 IL10 IL33 LTA TNF

Sources for Idiopathic Achalasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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