Aliases & Classifications for Idiopathic Achalasia

MalaCards integrated aliases for Idiopathic Achalasia:

Name: Idiopathic Achalasia 53
Esophageal Achalasia 53 72
Achalasia 53 72
Idiopathic Achalasia of Esophagus 53
Primary Achalasia 53
Achalasia Cardia 53

Classifications:



External Ids:

UMLS 72 C0014848 C1321756

Summaries for Idiopathic Achalasia

NIH Rare Diseases : 53 Achalasia is a disorder of the esophagus, the tube that carries food from the mouth to the stomach. It is characterized by enlargement of the esophagus, impaired ability of the esophagus to push food down toward the stomach (peristalsis), and failure of the ring-shaped muscle at the bottom of the esophagus (the lower esophageal sphincter) to relax. Achalasia is typically diagnosed in individuals between 25 and 60 years of age. The exact etiology is unknown, however, symptoms are caused by damage to the nerves of the esophagus. Familial studies have shown evidence of a potential genetic influence. When a genetic influence is suspected, achalasia is called familial esophageal achalasia. Treatment is aimed at reducing the pressure at the lower esophageal sphincter and may include Botox, medications, or surgery.

MalaCards based summary : Idiopathic Achalasia, also known as esophageal achalasia, is related to chagas disease and autoimmune disease. An important gene associated with Idiopathic Achalasia is AAAS (Aladin WD Repeat Nucleoporin), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Prednisone and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and lung, and related phenotypes are achalasia and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Idiopathic Achalasia

Diseases related to Idiopathic Achalasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 541)
# Related Disease Score Top Affiliating Genes
1 chagas disease 30.3 TNF NOS2 IL10
2 autoimmune disease 30.2 TNF IL10 HLA-DQB1
3 keratoconjunctivitis sicca 30.2 TNF IL10
4 poliomyelitis 30.2 TNF IL10
5 rubella 29.6 TNF IL10 HLA-DQB1
6 crohn's disease 29.5 TNF IL23R IL10
7 inflammatory bowel disease 29.4 TNF IL23R IL10
8 toxic shock syndrome 29.4 TNF LTA IL10
9 nervous system disease 29.3 TNF NOS2 IL10
10 arthritis 28.9 TNF LTA IL10 HLA-DQB1
11 malaria 27.4 TNF NOS2 LTA LOC111365141 IL33 IL10
12 achalasia-microcephaly syndrome 12.7
13 moyamoya disease 6 with or without achalasia 12.7
14 alacrima, achalasia, and mental retardation syndrome 12.7
15 deafness, congenital, with vitiligo and achalasia 12.6
16 obsolete: sporadic achalasia 12.1
17 obsolete: familial esophageal achalasia 12.1
18 mental retardation, x-linked, syndromic 17 12.1
19 achalasia, familial esophageal 11.8
20 jackhammer esophagus 11.5
21 hirschsprung disease 1 11.5
22 sjogren syndrome 11.5
23 muscular dystrophy, limb-girdle, autosomal recessive 18 11.5
24 aortic aneurysm, familial abdominal, 1 11.2
25 posterior column ataxia with retinitis pigmentosa 11.2
26 gmppa-cdg 11.2
27 achalasia 10.8
28 dyskinesia of esophagus 10.6
29 peanut allergy 10.5 IL10 HLA-DQB1
30 acute disseminated encephalomyelitis 10.5 IL10 HLA-DQB1
31 hernia, hiatus 10.4
32 aspiration pneumonia 10.4
33 dysphagia 10.4
34 pneumothorax 10.4
35 mycetoma 10.3 NOS2 IL10
36 squamous cell carcinoma 10.3
37 transient hypogammaglobulinemia of infancy 10.3 LTA IL10
38 buruli ulcer 10.3 LOC111365141 IL10
39 punctate inner choroidopathy 10.3 TNF IL10
40 beryllium disease 10.3 TNF HLA-DQB1
41 chronic beryllium disease 10.3 TNF HLA-DQB1
42 tropical endomyocardial fibrosis 10.3 TNF IL10
43 endomyocardial fibrosis 10.3 TNF IL10
44 cardiac sarcoidosis 10.3 TNF HLA-DQB1
45 constipation 10.3
46 multifocal choroiditis 10.3 TNF IL10
47 choroiditis 10.3 TNF IL10
48 tungiasis 10.3 TNF IL10
49 microscopic colitis 10.3 TNF HLA-DQB1
50 esophagitis, eosinophilic, 1 10.3

Graphical network of the top 20 diseases related to Idiopathic Achalasia:



Diseases related to Idiopathic Achalasia

Symptoms & Phenotypes for Idiopathic Achalasia

Human phenotypes related to Idiopathic Achalasia:

32
# Description HPO Frequency HPO Source Accession
1 achalasia 32 hallmark (90%) HP:0002571

GenomeRNAi Phenotypes related to Idiopathic Achalasia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.62 HLA-DQB1 IL10 LTA NOS2 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.62 HLA-DQB1 IL10 LTA NOS2 TNF

MGI Mouse Phenotypes related to Idiopathic Achalasia:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.09 AAAS HLA-DQB1 IL10 IL23R IL33 LTA
2 digestive/alimentary MP:0005381 10.06 AAAS HLA-DQB1 IL10 IL23R IL33 NOS2
3 behavior/neurological MP:0005386 10.04 AAAS HLA-DQB1 IL10 LTA NOS2 TNF
4 cellular MP:0005384 10.02 AAAS HLA-DQB1 IL10 IL33 NOS2 TNF
5 growth/size/body region MP:0005378 10.01 AAAS HLA-DQB1 IL10 IL23R LTA NOS2
6 homeostasis/metabolism MP:0005376 9.97 AAAS HLA-DQB1 IL10 IL23R IL33 LTA
7 hematopoietic system MP:0005397 9.91 HLA-DQB1 IL10 IL23R IL33 LTA NOS2
8 immune system MP:0005387 9.8 HLA-DQB1 IL10 IL23R IL33 LTA NOS2
9 liver/biliary system MP:0005370 9.55 HLA-DQB1 IL10 LTA NOS2 TNF
10 reproductive system MP:0005389 9.43 AAAS HLA-DQB1 IL10 IL33 NOS2 TNF
11 respiratory system MP:0005388 9.1 HLA-DQB1 IL10 IL33 LTA NOS2 TNF

Drugs & Therapeutics for Idiopathic Achalasia

Drugs for Idiopathic Achalasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 102)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2 Anti-Inflammatory Agents Phase 4
3 glucocorticoids Phase 4
4 Hormones Phase 4
5 Antineoplastic Agents, Hormonal Phase 4
6 Hormone Antagonists Phase 4
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
8 Neuromuscular Agents Phase 4
9
Ceftazidime Approved Phase 2, Phase 3 78439-06-2, 72558-82-8 5481173
10 Tin Fluorides Phase 3
11 Cephalosporins Phase 3
12 Antitubercular Agents Phase 3
13 Lactams Phase 3
14 beta-Lactams Phase 3
15 Anti-Infective Agents Phase 2, Phase 3
16 Antibiotics, Antitubercular Phase 2, Phase 3
17 Anti-Bacterial Agents Phase 2, Phase 3
18
Nitric Oxide Approved Phase 1, Phase 2 10102-43-9 145068
19
Alendronate Approved Phase 2 66376-36-1, 121268-17-5 2088
20
Naloxegol Approved Phase 2 854601-70-0
21
Vitamin D3 Approved, Nutraceutical Phase 2 67-97-0 6221 5280795
22
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
23 Cola Phase 2
24 Trace Elements Phase 2
25 Micronutrients Phase 2
26 Vitamins Phase 2
27 Diphosphonates Phase 2
28 Nutrients Phase 2
29 Calciferol Phase 2
30 Bone Density Conservation Agents Phase 2
31 Calcium, Dietary Phase 2
32 Peripheral Nervous System Agents Phase 2
33 Narcotics Phase 2
34 Narcotic Antagonists Phase 2
35 Analgesics, Opioid Phase 2
36
Amyl Nitrite Approved 8017-89-8, 463-04-7 10026
37
Methylene blue Approved, Investigational 61-73-4
38
Clavulanate Approved, Vet_approved 58001-44-8 5280980
39
Amoxicillin Approved, Vet_approved 26787-78-0 33613
40
Cefazolin Approved 25953-19-9 656510 33255
41
tannic acid Approved 1401-55-4
42
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
43
Promethazine Approved, Investigational 60-87-7 4927
44
Ondansetron Approved 99614-02-5 4595
45
Histamine Approved, Investigational 51-45-6 774
46
Diphenhydramine Approved, Investigational 58-73-1, 147-24-0 3100
47 Orange Approved
48
Budesonide Approved 51333-22-3 63006 5281004
49
Mirabegron Approved Early Phase 1 223673-61-8 9865528
50
Acetylcholine Approved, Investigational 51-84-3 187

Interventional clinical trials:

(show top 50) (show all 114)
# Name Status NCT ID Phase Drugs
1 Personalized Peroral Endoscopic Myotomy for Achalasia Unknown status NCT01570621 Phase 4
2 A Pilot Study Assessing the Efficacy of Steroids in the Treatment of Achalasia Enrolling by invitation NCT01903486 Phase 4 Apo-Prednisone Cordorol, Detasone - Prednisone
3 Prospective Single-Blinded Randomized Controlled Trial Comparing Botox or Botox With Esophageal Dilation in Patients With Achalasia Enrolling by invitation NCT03654066 Phase 4 Botulinum toxin type A
4 Botulinum Toxin Pyloroplasty to Reduce Postoperative Nausea and Vomiting After Sleeve Gastrectomy Enrolling by invitation NCT03701919 Phase 4 Botulinum toxin pyloroplasty;Normal saline pyloric injection
5 Comparison of Solid-State Esophageal Manometry and Water Perfused Anorectal Manometry Catheters With Air Filled Multi-Balloon Esophageal and Anorectal Manometry Catheters Terminated NCT00204763 Phase 4
6 Peroral Endoscopic Myotomy for Primary Esophageal Achalasia Completed NCT01560559 Phase 3
7 Randomized Control Study Comparing Single-Versus Multiple-dose Antimicrobial Prophylaxis for Peroral Endoscopic Myotomy in Achalasia Recruiting NCT03784365 Phase 3 3Rd Generation Cephalosporins
8 Single- Versus Multiple-dose Antimicrobial Prophylaxis for The Prevention of Infectious Complications Associated With Peroral Endoscopic Myotomy(POEM) for Achalasia: A Triple-Blind, Randomized Controlled, Non-Inferiority Trial Active, not recruiting NCT03404739 Phase 2, Phase 3 Saline Solution;Ceftazidime
9 Efficacy of Dark Chocolate in Achalasia Patients: Placebo-Controlled Study Unknown status NCT00790465 Phase 1, Phase 2
10 Endoscopic Submucosal Tunnel Dissection for Endolumenal Partial Myotomy of the Lower Esophageal Sphincter for Achalasia Unknown status NCT01302288 Phase 2
11 Prospective Study on the Feasibility and Effectiveness of Per-Oral Endoscopic Myotomy (P.O.E.M.) for Treatment of Primary Esophageal Motility Disorders Unknown status NCT01524458 Phase 1, Phase 2
12 Per-Oral Endoscopic Myotomy (P.O.E.M.) for Treatment of Primary Esophageal Motility Disorders Unknown status NCT01524471 Phase 2
13 Endoscopic Submucosal Tunnel Dissection for Endolumenal Partial Myotomy of the Lower Esophageal Sphincter for Atypical Primary Motility Disorders Such as Achalasia and Esophageal Spasm Unknown status NCT01302301 Phase 2
14 Prospective Study on the Feasibility and Results of the Treatment of Idiopathic Achalasia With the POEM (Per Oral Endoscopic Myotomy) Technique Completed NCT02259283 Phase 2
15 Peroral Endoscopic Myotomy (POEM) for the Treatment of Achalasia Completed NCT02073578 Phase 1, Phase 2
16 Randomized Study to Compare Pneumatic Dilatation With Surgical Myotomy for Treatment of Achalasia - Long Term Follow up Completed NCT02086669 Phase 2
17 A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Single-dose, Phase 2a Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IW-1701 in Patients With Achalasia Completed NCT02931565 Phase 2 IW-1701;Matching Placebo
18 Endoscopic Esophageal Myotomy for the Treatment of Achalasia Completed NCT01873300 Phase 1, Phase 2
19 Endoscopic Injection of Botulinum Toxin in Patients With Hypercontractile Esophageal Motility Disorders: a Prospective, Randomized, Double-blind, Controlled Study Completed NCT01955174 Phase 2 Esophageal endoscopic injection of botulinum toxin
20 The Impact of Bisphosphonates on Bone Loss in Patients Undergoing Surgery and Postoperative Chemotherapy for Gynecologic Malignancies. Completed NCT00593580 Phase 2 placebo;alendronate/cholecalciferol
21 Movantik for Opioid-Related Esophageal Disorders Terminated NCT02998606 Phase 2 Naloxegol;Placebo Oral Capsule
22 Phase II Study of Evaluation of the Safety and Effectiveness of Tailored Transoral Incisionless Fundoplication (TIF) Using EsophyX for the Treatment of GERD Withdrawn NCT01025739 Phase 2
23 A Prospective Trial Comparing POEM to Pneumatic Dilatation for Treatment of Achalasia Cardia Unknown status NCT02025790
24 Screening for Dysplasia in Longstanding Idiopathic Achalasia: a Prospective Study Unknown status NCT02010983
25 Peroral Endoscopic Myotomy for Esophageal Achalasia: Randomized Comparison of Water-Jet Assisted Versus Conventional Dissection Technique Unknown status NCT01742494
26 Double Blind Randomized Clinical Trial Comparing Short Versus Long Esophageal Myotomy in Per Oral Endoscopic Myotomy for Achalasia Cardia Unknown status NCT03186248
27 Clinical Impact of Peroral Endoscopic Myotomy for Esophageal Achalasia Unknown status NCT01649843
28 Peroral Endoscopic Remyotomy for Failed Heller Myotomy Unknown status NCT01637311
29 POEM a Novel Endoscopic Treatment for Achalasia Unknown status NCT01512719
30 Short and Long Term Outcomes of Heller Myotomy Unknown status NCT00519220
31 Peroral Endoscopic Myotomy Versus Pneumatic Dilation for Esophageal Achalasia: a Prospective Randomized Controlled Trial Unknown status NCT01768091
32 Safety,Efficacy and Cost-effectiveness of Snare-assisted POEM for Treatment of Esophageal Achalasia Unknown status NCT02999451
33 Bacteremia and Procalcitonin Levels in Peroral Endoscopic Myotomy for Achalasia Unknown status NCT01750385 no antibiotic prophylaxis;second-generation cephalosporin
34 Laparoscopy Heller Myotomy With Fundoplication Associated Versus Peroral Endoscopic Myotomy (POEM) Unknown status NCT02138643
35 To Assess the Feasibility of Same Day Discharge Following a POEM Procedure Unknown status NCT02572193
36 Efficacy and Safety Study of Hot Water Drinking Therapy in Achalasia Patients Unknown status NCT01863966
37 Endoscopic Submucosal Tunnel Dissection for Endoluminal Partial Myotomy of the Lower Esophageal Sphincter in Patients With Spastic Esophageal Disorders Such as Achalasia Unknown status NCT02425033
38 A Randomized Comparison of Laparoscopic Myotomy and Pneumatic Dilatation for Achalasia Unknown status NCT00188344
39 Clinical Outcomes of Peroral Endoscopic Myotomy for Esophageal Outflow Obstruction Unknown status NCT02989883
40 Achalasia; Mechanisms Underlying Persistent Symptoms After Treatment Unknown status NCT02055469
41 Peroral Endoscopic Myotomy (POEM) For The Treatment Of Achalasia: A Retrospective And Prospective Multicenter Registry. Unknown status NCT02162589
42 Endoscopic Submucosal Tunnel Dissection Versus Video-assisted Thoracoscopic Surgery for Upper Gastrointestinal Submucosal Tumors: a Prospective Randomized Controlled Trial Unknown status NCT01768104
43 Assessment of Esophageal Motility With Transnasal Endoscopy Unknown status NCT01658865
44 Pyloric Sphincter Pressure and Geometry Assessment Using EndoFlip Unknown status NCT02446119
45 Transnasal Endoscopic Evaluation of Swallowing: Functional Esophagoscopy Using an Ultrathin Video Endoscope in Neurogenic Dysphagia Unknown status NCT01995929
46 Observational Field Study of Acute Esophageal Food Bolus Impaction by Mean Esophageal Manometry and 24h-pH-monitoring Unknown status NCT01447823
47 Reversibility of Esophageal Dysmotilities Associated With Gastric Banding After Conversion to Gastric Bypass Unknown status NCT00680030
48 Randomized Prospective Trial of Laparoscopic Heller Myotomy and Partial Fundoplication for the Treatment of Idiopathic Esophageal Achalasia Completed NCT00490750
49 Prospective Study to Assess the Diagnostic Utility of Amyl Nitrite in Patients With Suspected Achalasia Undergoing High Resolution Esophageal Manometry (HREM) Completed NCT02428959 Amyl Nitrite
50 To Find Out the Genetic Relationship Between the Early-Onset Achalasia and AAAS Gene Completed NCT00856921

Search NIH Clinical Center for Idiopathic Achalasia

Genetic Tests for Idiopathic Achalasia

Anatomical Context for Idiopathic Achalasia

MalaCards organs/tissues related to Idiopathic Achalasia:

41
Bone, Testes, Lung, Smooth Muscle, Heart, Prostate, Small Intestine

Publications for Idiopathic Achalasia

Articles related to Idiopathic Achalasia:

(show top 50) (show all 842)
# Title Authors PMID Year
1
POEM in Latin America: The Rise of a New Standard. 38
30702485 2019
2
Anesthesia for peroral endoscopic myotomy in Japan. 38
30994477 2019
3
Peroral endoscopic myotomy with endoscopic fundoplication in a patient with idiopathic achalasia. 38
31398744 2019
4
[Practice guideline of peroral endoscopic myotomy of achalasia: Zhongshan experience]. 38
31302957 2019
5
Identification of human herpes virus 1 encoded microRNAs in biopsy samples of lower esophageal sphincter muscle during per-oral endoscopic myotomy for esophageal achalasia. 38
31325192 2019
6
Systematic Review and Bayesian Network Meta-Analysis Comparing Laparoscopic Heller Myotomy, Pneumatic Dilatation, and Peroral Endoscopic Myotomy for Esophageal Achalasia. 38
31364910 2019
7
Validation of new Japanese classification system for esophageal achalasia. 38
30771041 2019
8
Resection of the Gastroesophageal Junction and Roux-en-Y Reconstruction as a New Alternative for the Treatment of Recurrent Achalasia: Outcomes in a Short Series of Patients. 38
31161951 2019
9
Multicenter collaborative retrospective evaluation of peroral endoscopic myotomy for esophageal achalasia: analysis of data from more than 1300 patients at eight facilities in Japan. 38
31183791 2019
10
Laparoscopic Heller Myotomy: A Fundoplication Is Necessary to Control Gastroesophageal Reflux. 38
31009312 2019
11
Incidence and risk factors for esophageal cancer following achalasia treatment: national population-based case-control study. 38
30809653 2019
12
Achalasia and associated esophageal cancer risk: What lessons can we learn from the molecular analysis of Barrett's-associated adenocarcinoma? 38
31059738 2019
13
The treatment of achalasia patients with esophageal varices: an international study. 38
31065374 2019
14
Management of Esophageal Achalasia after Roux-en-Y Gastric Bypass: Narrative Review of the Literature. 38
30778843 2019
15
Peroral Endoscopic Myotomy with the Stag Beetle Knife (SB Knife): Feasibility and Follow-Up. 38
31081498 2019
16
[PER-ORAL ENDOSCOPIC MYOTOMY - SUMMARY OF FIVE YEARS EXPERIENCE]. 38
31032552 2019
17
Dor versus Toupet fundoplication after Laparoscopic Heller Myotomy: Systematic review and Bayesian meta-analysis of randomized controlled trials. 38
31031056 2019
18
The assessment of the esophageal motility of children with esophageal disorders by the detailed observation of the pH-multichannel intraluminal impedance waveform and baseline impedance: screening test potential. 38
30145680 2019
19
Eosinophilic esophagitis and achalasia - just a coincidence? 38
30754060 2019
20
Pneumatic dilation versus laparoscopic Heller's myotomy in the treatment of achalasia: systematic review and meta-analysis based on randomized controlled trials. 38
30380036 2019
21
Corrigendum to: "Modern Management of Esophageal Achalasia: From Pathophysiology to Treatment," Curr Prob Surg 2018; 55 (1):1-38. 38
30777151 2019
22
Importance of Barium Swallow Test and Chest CT Scan for Correct Diagnosis of Achalasia in the Primary Care Setting. 38
30662021 2019
23
Patient with mediastinitis caused by delayed mucosal damage after peroral endoscopic myotomy. 38
29656451 2019
24
Per oral endoscopic myotomy in a pediatric patient with achalasia. 38
31095223 2019
25
Bridging the Gap between Advancements in the Evolution of Diagnosis and Treatment towards Better Outcomes in Achalasia. 38
30881999 2019
26
Pseudoachalasia as First Manifestation of a Malignancy. 38
30602160 2019
27
Outcome of peroral endoscopic myotomy in children with achalasia. 38
30671667 2019
28
A Thousand and One Laparoscopic Heller Myotomies for Esophageal Achalasia: a 25-Year Experience at a Single Tertiary Center. 38
30238248 2019
29
[Esophageal achalasia]. 38
30855594 2019
30
Experience in treatment of patients with esophageal achalasia. 38
31055556 2019
31
Heller myotomy is the optimal index procedure for esophageal achalasia in adolescents and young adults. 38
30552502 2018
32
Clinical decision making and application of an active rehabilitation program for a person with the neuromuscular symptoms of Allgrove syndrome: a case report. 38
30501443 2018
33
Left Atrial Compression Secondary to Massive Esophageal Dilatation in a Patient With Idiopathic Achalasia. 38
30582093 2018
34
Results of pneumatic dilation in treating achalasia: predictive factors. 38
29766515 2018
35
Bladder pressure monitoring and CO2 gas-related adverse events during per-oral endoscopic myotomy. 38
29488045 2018
36
Advances in Management of Esophageal Motility Disorders. 38
29702296 2018
37
WATER INGESTION DYNAMICS IN PATIENTS WITH ACHALASIA: INFLUENCE OF SEX AND AGE. 38
30184021 2018
38
Expanding the clinical phenotype of IARS2-related mitochondrial disease. 38
30419932 2018
39
Clinical factors and high-resolution manometry predicting response to surgery for achalasia in children. 38
29937012 2018
40
The 2018 ISDE achalasia guidelines. 38
30169645 2018
41
[Esophageal Achalasia after Surgery for Lung Cancer]. 38
30185741 2018
42
Esophageal achalasia and pregnancy: own observations in 43 patients and a review of the literature. 38
29931525 2018
43
Clinical practice guidelines for peroral endoscopic myotomy. 38
30022514 2018
44
The influence of hospital volume upon clinical management and outcomes of esophageal achalasia: an English national population-based cohort study. 38
29985997 2018
45
Per-oral endoscopic myotomy for esophageal achalasia in a case of Allgrove syndrome. 38
29383495 2018
46
Budd-Chiari Syndrome and Esophageal Achalasia: Unrecognized Intrahepatic Cholangiocarcinoma Invading Multiple Organs. 38
29526953 2018
47
Treatment of Idiopathic Achalasia with Per-Oral Esophageal Myotomy. 38
30872910 2018
48
Esophagography in Patients With Esophageal Achalasia Diagnosed With High-resolution Esophageal Manometry. 38
29969858 2018
49
Esophageal achalasia: current diagnosis and treatment. 38
29804476 2018
50
Obstructive bronchitis and recurrent pneumonia in esophageal achalasia in a child: A CARE compliant case report. 38
29879065 2018

Variations for Idiopathic Achalasia

Expression for Idiopathic Achalasia

Search GEO for disease gene expression data for Idiopathic Achalasia.

Pathways for Idiopathic Achalasia

Pathways related to Idiopathic Achalasia according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.71 TNF NOS2 LTA IL33 IL23R IL10
2
Show member pathways
13.39 TNF NOS2 LTA IL33 IL23R IL10
3
Show member pathways
12.67 TNF NOS2 LTA IL33 IL23R IL10
4
Show member pathways
12.63 TNF LTA IL10 HLA-DQB1
5
Show member pathways
12.33 TNF IL23R IL10 HLA-DQB1
6
Show member pathways
12.29 TNF NOS2 IL23R IL10
7 12.13 TNF LTA HLA-DQB1
8
Show member pathways
11.96 TNF NOS2 IL33
9
Show member pathways
11.94 TNF NOS2 IL10 HLA-DQB1
10 11.91 VIPR1 TNF IL10
11 11.88 TNF NOS2 IL10 HLA-DQB1
12
Show member pathways
11.67 TNF LTA IL23R IL10
13 11.66 TNF NOS2 IL10
14 11.51 TNF NOS2 IL23R IL10
15 11.49 TNF NOS2 IL10
16 11.43 TNF NOS2 IL10
17 11.17 TNF IL10
18 11.15 TNF IL10
19 11.1 TNF IL33
20 11.03 TNF IL10
21 10.97 LTA IL10
22 10.95 TNF LTA IL10
23 10.92 TNF LTA IL33 IL23R IL10

GO Terms for Idiopathic Achalasia

Biological processes related to Idiopathic Achalasia according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.85 TNF LTA IL10 HLA-DQB1
2 defense response to bacterium GO:0042742 9.79 TNF NOS2 IL10
3 cytokine-mediated signaling pathway GO:0019221 9.76 TNF NOS2 IL23R IL10
4 cellular response to lipopolysaccharide GO:0071222 9.74 TNF NOS2 IL10
5 negative regulation of mitotic cell cycle GO:0045930 9.61 TNF IL10
6 negative regulation of interleukin-6 production GO:0032715 9.6 TNF IL10
7 negative regulation of interferon-gamma production GO:0032689 9.59 IL33 IL10
8 regulation of synapse organization GO:0050807 9.58 TNF IL10
9 positive regulation of cytokine secretion GO:0050715 9.58 TNF IL10
10 positive regulation of osteoclast differentiation GO:0045672 9.56 TNF IL23R
11 positive regulation of macrophage activation GO:0043032 9.54 IL33 IL10
12 positive regulation of glial cell proliferation GO:0060252 9.52 TNF LTA
13 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.51 TNF IL10
14 positive regulation of interferon-gamma production GO:0032729 9.5 TNF LTA IL23R
15 positive regulation of chemokine secretion GO:0090197 9.49 TNF IL33
16 endothelial cell apoptotic process GO:0072577 9.48 TNF IL10
17 response to lipopolysaccharide GO:0032496 9.46 NOS2 LTA IL23R IL10
18 positive regulation of neuroinflammatory response GO:0150078 9.43 TNF IL33
19 negative regulation of cytokine secretion involved in immune response GO:0002740 9.4 TNF IL10
20 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.37 TNF LTA
21 receptor biosynthetic process GO:0032800 9.26 TNF IL10
22 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 8.96 TNF LTA
23 negative regulation of growth of symbiont in host GO:0044130 8.8 TNF LTA IL10

Molecular functions related to Idiopathic Achalasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.96 TNF LTA
2 cytokine activity GO:0005125 8.92 TNF LTA IL33 IL10

Sources for Idiopathic Achalasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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