MCID: IDP049
MIFTS: 20

Idiopathic Anterior Uveitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Idiopathic Anterior Uveitis

MalaCards integrated aliases for Idiopathic Anterior Uveitis:

Name: Idiopathic Anterior Uveitis 59
Anterior Uveitis Idiopathic 73

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 59  
Rare eye diseases


External Ids:

Orphanet 59 ORPHA280914
UMLS via Orphanet 74 C0339315
ICD10 via Orphanet 34 H20.0 H20.1 H20.2 more
UMLS 73 C0339315

Summaries for Idiopathic Anterior Uveitis

MalaCards based summary : Idiopathic Anterior Uveitis, also known as anterior uveitis idiopathic, is related to uveitis and anterior uveitis. An important gene associated with Idiopathic Anterior Uveitis is CCR2 (C-C Motif Chemokine Receptor 2), and among its related pathways/superpathways are CCR5 Pathway in Macrophages and Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions. Affiliated tissues include eye and t cells.

Related Diseases for Idiopathic Anterior Uveitis

Diseases in the Idiopathic Anterior Uveitis family:

Idiopathic Posterior Uveitis

Diseases related to Idiopathic Anterior Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 uveitis 10.2
2 anterior uveitis 10.2
3 human immunodeficiency virus type 1 9.0 CCR2 CXCR1

Symptoms & Phenotypes for Idiopathic Anterior Uveitis

Drugs & Therapeutics for Idiopathic Anterior Uveitis

Search Clinical Trials , NIH Clinical Center for Idiopathic Anterior Uveitis

Genetic Tests for Idiopathic Anterior Uveitis

Anatomical Context for Idiopathic Anterior Uveitis

MalaCards organs/tissues related to Idiopathic Anterior Uveitis:

41
Eye, T Cells

Publications for Idiopathic Anterior Uveitis

Articles related to Idiopathic Anterior Uveitis:

# Title Authors Year
1
Elevated interleukin 37 expression associated with disease activity in HLA-B27 associated anterior uveitis and idiopathic anterior uveitis. ( 29424310 )
2018
2
Comparison of the Diagnostic Power of Serum IL-6, IL-8 and TNF-I+ for the Idiopathic Anterior Uveitis in Children. ( 29226649 )
2017
3
Expression profile of IL-1 family cytokines in aqueous humor and sera of patients with HLA-B27 associated anterior uveitis and idiopathic anterior uveitis. ( 26116905 )
2015
4
Chemokine gene polymorphisms in idiopathic anterior uveitis. ( 16950632 )
2006
5
Disturbed expression of Fas/FasL on CD4(+) and CD8(+)T cells in Behcet's disease, Vogt-Koyanagi-Harada syndrome, and idiopathic anterior uveitis. ( 11815887 )
2001
6
Thalidomide effectiveness for bilateral chronic idiopathic anterior uveitis in a three-year-old child. ( 11125274 )
2001
7
Characterization of T cells and cytokines in the aqueous humour (AH) in patients with Fuchs' heterochromic cyclitis (FHC) and idiopathic anterior uveitis (IAU). ( 9472671 )
1998
8
Serum alpha-1 acid glycoprotein levels in acute idiopathic anterior uveitis. ( 1776767 )
1991
9
Serum beta-2 microglobulin level in acute idiopathic anterior uveitis. ( 2672696 )
1989
10
Serum fibrin degradation products in acute idiopathic anterior uveitis. ( 3811876 )
1986

Variations for Idiopathic Anterior Uveitis

Expression for Idiopathic Anterior Uveitis

Search GEO for disease gene expression data for Idiopathic Anterior Uveitis.

Pathways for Idiopathic Anterior Uveitis

Pathways related to Idiopathic Anterior Uveitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.71 CCR2 CXCR1
2
Show member pathways
10.69 CCR2 CXCR1

GO Terms for Idiopathic Anterior Uveitis

Biological processes related to Idiopathic Anterior Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemotaxis GO:0006935 9.16 CCR2 CXCR1
2 chemokine-mediated signaling pathway GO:0070098 8.96 CCR2 CXCR1
3 dendritic cell chemotaxis GO:0002407 8.62 CCR2 CXCR1

Molecular functions related to Idiopathic Anterior Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor activity GO:0004930 9.16 CCR2 CXCR1
2 obsolete signal transducer activity GO:0004871 8.96 CCR2 CXCR1
3 chemokine receptor activity GO:0004950 8.62 CCR2 CXCR1

Sources for Idiopathic Anterior Uveitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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