MCID: IDP049
MIFTS: 35

Idiopathic Anterior Uveitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Idiopathic Anterior Uveitis

MalaCards integrated aliases for Idiopathic Anterior Uveitis:

Name: Idiopathic Anterior Uveitis 58
Anterior Uveitis Idiopathic 71

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 58  
Rare eye diseases


External Ids:

ICD10 via Orphanet 33 H20.0 H20.1 H20.2 more
UMLS via Orphanet 72 C0339315
Orphanet 58 ORPHA280914
UMLS 71 C0339315

Summaries for Idiopathic Anterior Uveitis

MalaCards based summary : Idiopathic Anterior Uveitis, also known as anterior uveitis idiopathic, is related to iridocyclitis and juvenile arthritis. An important gene associated with Idiopathic Anterior Uveitis is CCR2 (C-C Motif Chemokine Receptor 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include eye, t cells and monocytes, and related phenotypes are red eye and ocular pain

Related Diseases for Idiopathic Anterior Uveitis

Diseases in the Idiopathic Anterior Uveitis family:

Idiopathic Posterior Uveitis

Diseases related to Idiopathic Anterior Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 402)
# Related Disease Score Top Affiliating Genes
1 iridocyclitis 30.5 TNF IL6
2 juvenile arthritis 29.8 IL6 CXCL8
3 uveitis 29.5 TNF IL6 CXCR1 CXCL8
4 juvenile rheumatoid arthritis 29.2 TNF IL6 CXCL8
5 haemophilus influenzae 10.2 TNF CXCL8
6 toxicodendron dermatitis 10.2 TNF CXCL8
7 mycobacterium abscessus 10.2 TNF CXCL8
8 cardiac rupture 10.2 TNF CXCL8
9 aspiration pneumonitis 10.2 TNF CXCL8
10 pustulosis of palm and sole 10.2 TNF CXCL8
11 cytomegalovirus retinitis 10.2 TNF CCR2
12 tuberculous meningitis 10.2 TNF CXCL8
13 sapho syndrome 10.2 TNF CXCL8
14 cryptogenic organizing pneumonia 10.2 TNF CXCL8
15 clonorchiasis 10.2 TNF CXCL8
16 cardiac sarcoidosis 10.1 TNF CXCL8
17 trichuriasis 10.1 TNF CXCL8
18 opisthorchiasis 10.1 TNF CXCL8
19 pleural tuberculosis 10.1 TNF CXCL8
20 neutrophil migration 10.1 CXCR1 CXCL8
21 amebiasis 10.1 TNF CXCL8
22 crohn's colitis 10.1 TNF CXCL8
23 cyclic neutropenia 10.1 TNF CXCL8
24 pyoderma 10.1 TNF CXCL8
25 pyoderma gangrenosum 10.1 TNF CXCL8
26 churg-strauss syndrome 10.1 TNF CXCL8
27 dermatitis herpetiformis 10.1 TNF CXCL8
28 keratopathy 10.1 TNF CXCL8
29 aseptic meningitis 10.1 TNF CXCL8
30 pleurisy 10.0 TNF CXCL8
31 allergic conjunctivitis 10.0 TNF CXCL8
32 acute transverse myelitis 10.0 IL6 CXCL8
33 brain injury 10.0 IL6 CCR2
34 fuchs' heterochromic uveitis 10.0 IL6 CXCL8
35 acute monoblastic leukemia 9.9 IL6 CXCL8
36 recurrent corneal erosion 9.9 IL6 CXCL8
37 denture stomatitis 9.9 IL6 CXCL8
38 pyuria 9.9 IL6 CXCL8
39 external pathological resorption 9.9 TNF IL6
40 papillary conjunctivitis 9.9 IL6 CXCL8
41 giant papillary conjunctivitis 9.9 IL6 CXCL8
42 scorpion envenomation 9.9 TNF IL6
43 radiculopathy 9.9 IL6 CXCL8
44 conjunctivochalasis 9.9 IL6 CXCL8
45 ascaris lumbricoides infection 9.9 IL6 CXCL8
46 angioimmunoblastic lymphadenopathy with dysproteinemia 9.9 TNF IL6
47 relapsing polychondritis 9.9 IL6 CXCL8
48 retinal vascular occlusion 9.9 IL6 CXCL8
49 capillary leak syndrome 9.9 IL6 CXCL8
50 necrotizing fasciitis 9.9 IL6 CXCL8

Graphical network of the top 20 diseases related to Idiopathic Anterior Uveitis:



Diseases related to Idiopathic Anterior Uveitis

Symptoms & Phenotypes for Idiopathic Anterior Uveitis

Human phenotypes related to Idiopathic Anterior Uveitis:

58 31 (show all 12)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 red eye 58 31 hallmark (90%) Very frequent (99-80%) HP:0025337
2 ocular pain 58 31 hallmark (90%) Very frequent (99-80%) HP:0200026
3 glaucoma 58 31 frequent (33%) Frequent (79-30%) HP:0000501
4 macular edema 58 31 frequent (33%) Frequent (79-30%) HP:0040049
5 photophobia 58 31 occasional (7.5%) Occasional (29-5%) HP:0000613
6 miosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0000616
7 blurred vision 58 31 occasional (7.5%) Occasional (29-5%) HP:0000622
8 ocular hypertension 58 31 occasional (7.5%) Occasional (29-5%) HP:0007906
9 posterior subcapsular cataract 58 31 occasional (7.5%) Occasional (29-5%) HP:0007787
10 nuclear cataract 58 31 occasional (7.5%) Occasional (29-5%) HP:0100018
11 posterior synechiae of the anterior chamber 58 31 occasional (7.5%) Occasional (29-5%) HP:0011484
12 increased cup-to-disc ratio 58 31 very rare (1%) Very rare (<4-1%) HP:0012796

Drugs & Therapeutics for Idiopathic Anterior Uveitis

Search Clinical Trials , NIH Clinical Center for Idiopathic Anterior Uveitis

Genetic Tests for Idiopathic Anterior Uveitis

Anatomical Context for Idiopathic Anterior Uveitis

MalaCards organs/tissues related to Idiopathic Anterior Uveitis:

40
Eye, T Cells, Monocytes

Publications for Idiopathic Anterior Uveitis

Articles related to Idiopathic Anterior Uveitis:

(show top 50) (show all 61)
# Title Authors PMID Year
1
Similarities in clinical course and outcome between juvenile idiopathic arthritis (JIA)-associated and ANA-positive idiopathic anterior uveitis: data from a population-based nationwide study in Germany. 61
32293540 2020
2
Inhibitory role of transforming growth factor β2 in experimental autoimmune anterior uveitis. 61
30719689 2019
3
Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans for Juvenile Idiopathic Arthritis-Associated and Idiopathic Chronic Anterior Uveitis. 61
29806733 2019
4
Increased Circulating Proinflammatory T Lymphocytes in Children with Different Forms of Anterior Uveitis: Results from a Pilot Study. 61
29771573 2019
5
Long-term results of cataract surgery in patients with anterior uveitis. 61
28602016 2018
6
ADJUVITE: a double-blind, randomised, placebo-controlled trial of adalimumab in early onset, chronic, juvenile idiopathic arthritis-associated anterior uveitis. 61
29275333 2018
7
Peripheral blood monocytes reveal an activated phenotype in pediatric uveitis. 61
28923439 2018
8
Uveitis in Siriraj Hospital: pattern differences between immune-related uveitis and infectious uveitis in a university-based tertiary care hospital. 61
28429127 2018
9
Elevated Interleukin 37 Expression Associated With Disease Activity in HLA-B27 Associated Anterior Uveitis and Idiopathic Anterior Uveitis. 61
29424310 2018
10
Intravitreal Dexamethasone Implant (Ozurdex) to Control Recurrent Severe Idiopathic Uveitis Leads to Improvement in Steroid-Induced Diabetes Mellitus. 61
27540825 2018
11
The Phenotype of Monocytes in Anterior Uveitis Depends on the HLA-B27 Status. 61
30105034 2018
12
The Use of Topical Non-steroidal Anti-inflammatory Drugs for Uveitic Cystoid Macular Edema. 61
28080174 2018
13
A Focus on the Epidemiology of Uveitis. 61
27467180 2018
14
Uveitic Glaucoma: Long-term Clinical Outcome and Risk Factors for Progression. 61
27937076 2017
15
Comparison of the Diagnostic Power of Serum IL-6, IL-8 and TNF-α for the Idiopathic Anterior Uveitis in Children. 61
29226649 2017
16
Intraocular Inflammation in Diabetic Populations. 61
28791537 2017
17
Patterns of Uveitis in a Tertiary Care Referral Institute in Saudi Arabia. 61
26910754 2017
18
Clinical Patterns of Uveitis in a Tertiary Center in North China. 61
27070829 2017
19
Phacoemulsification with primary implantation of an intraocular lens in patients with uveitis. 61
28860705 2017
20
Changes in Corneal Thickness and Specular Microscopic Indices in Acute Unilateral Anterior Uveitis. 61
27182691 2016
21
Elevated S100A8/A9 and S100A12 Serum Levels Reflect Intraocular Inflammation in Juvenile Idiopathic Arthritis-Associated Uveitis: Results From a Pilot Study. 61
26624497 2015
22
Tubulointerstitial Nephritis and Uveitis Syndrome in an Elderly Man: Case Report and Literature Review. 61
26632725 2015
23
Expression profile of IL-1 family cytokines in aqueous humor and sera of patients with HLA-B27 associated anterior uveitis and idiopathic anterior uveitis. 61
26116905 2015
24
Causes of Uveitis in a Tertiary Center in Chile: A Cross-sectional Retrospective Review. 61
25437569 2015
25
Association study of MICA-TM and HLA-class I polymorphism with uveitis in South Tunisian population. 61
25468490 2015
26
Diagnostic utility of aqueocentesis and aqueous humor analysis in dogs and cats with anterior uveitis. 61
23910096 2014
27
Correlation between disease severity and presence of ocular autoantibodies in juvenile idiopathic arthritis-associated uveitis. 61
24764059 2014
28
Prognostic value of antinuclear antibodies in juvenile idiopathic arthritis and anterior uveitis. Results from a systematic literature review. 61
24879943 2014
29
Phacoemulsification with intraocular lens implantation in patients with anterior uveitis. 61
23692885 2013
30
Causes of uveitis in a tertiary center in Western Saudi Arabia. 61
23552591 2013
31
Tubulointerstitial nephritis and uveitis syndrome in a twelve-year-old girl. 61
23691408 2013
32
Uveitis with myasthenia gravis--a rare association. 61
23323580 2013
33
The association of human leukocyte antigen B27 with anterior uveitis in patients from the western region of Saudi Arabia: a retrospective study. 61
24204112 2013
34
Subconjunctival sirolimus for the treatment of chronic active anterior uveitis: results of a pilot trial. 61
22465364 2012
35
Viral anterior uveitis. 61
21918442 2011
36
Inhibition of complement alternative pathway suppresses experimental autoimmune anterior uveitis by modulating T cell responses. 61
21216963 2011
37
[Pharmacological treatment of recurrent idiopathic anterior uveitis]. 61
21913437 2011
38
[The diagnosis and treatment analysis of anterior uveitis]. 61
20388318 2010
39
Clinical features of patients with diabetes mellitus presenting with their first episode of uveitis. 61
20001257 2009
40
Crucial role of apoptosis in the resolution of experimental autoimmune anterior uveitis. 61
17962461 2007
41
Safety and efficacy of intraoperative intravitreal injection of triamcinolone acetonide injection after phacoemulsification in cases of uveitic cataract. 61
17720079 2007
42
Association between heat shock protein 70/Hom genetic polymorphisms and uveitis in patients with sarcoidosis. 61
17591867 2007
43
[Indications and adverse events with the use of anti-TNFalpha agents in pediatric rheumatology: experience of a single center]. 61
17572652 2007
44
Pattern of childhood-onset uveitis in a referral center in Tunisia, North Africa. 61
16911984 2006
45
Chemokine gene polymorphisms in idiopathic anterior uveitis. 61
16950632 2006
46
Clinical patterns and characteristics of uveitis in a tertiary center for uveitis in China. 61
16282128 2005
47
Psoriatic uveitis: a distinct clinical entity? 61
15652834 2005
48
High levels of IgG class antibodies to recombinant HSP60 kDa of Yersinia enterocolitica in sera of patients with uveitis. 61
14736785 2004
49
Disturbed expression of Fas/FasL on CD4(+) and CD8(+)T cells in Behcet's disease, Vogt-Koyanagi-Harada syndrome, and idiopathic anterior uveitis. 61
11815887 2001
50
Thalidomide effectiveness for bilateral chronic idiopathic anterior uveitis in a three-year-old child. 61
11125274 2001

Variations for Idiopathic Anterior Uveitis

Expression for Idiopathic Anterior Uveitis

Search GEO for disease gene expression data for Idiopathic Anterior Uveitis.

Pathways for Idiopathic Anterior Uveitis

Pathways related to Idiopathic Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.71 TNF IL6 IL37 CXCR1 CXCL8 CCR2
2
Show member pathways
13.54 TNF IL6 CXCR1 CXCL8 CCR2
3
Show member pathways
13.3 TNF IL6 IL37 CXCR1 CXCL8 CCR2
4
Show member pathways
13.14 TNF IL6 CXCR1 CXCL8 CCR2
5
Show member pathways
13.08 TNF IL6 IL37 CXCL8 CCR2
6
Show member pathways
12.99 TNF IL6 CXCR1 CXCL8 CCR2
7
Show member pathways
12.47 TNF IL6 IL37 CXCL8
8
Show member pathways
12.15 TNF IL6 CXCL8
9
Show member pathways
12.13 TNF IL6 CXCL8
10 12.12 TNF IL6 CXCL8
11 12.08 TNF IL6 CXCL8
12
Show member pathways
12.07 TNF IL6 CXCL8
13
Show member pathways
12.06 TNF IL6 CXCL8
14 12.04 TNF IL6 CXCL8
15
Show member pathways
12 TNF IL6 CXCL8
16 11.98 TNF IL6 CXCL8
17 11.84 TNF IL6 CXCL8
18 11.81 TNF IL6 CXCL8
19 11.74 TNF IL6 CXCL8
20 11.72 TNF IL6 CXCL8
21 11.65 TNF IL6 CXCL8
22 11.64 TNF IL6 CXCL8 CCR2
23 11.55 TNF IL6 CXCL8
24
Show member pathways
11.43 TNF IL6 CXCL8
25
Show member pathways
11.43 TNF IL6 IL37 CXCR1 CXCL8 CCR2
26 11.4 TNF IL6
27 11.37 TNF CCR2
28 11.37 IL6 CXCR1
29 11.37 TNF IL6
30 11.36 IL6 CXCL8
31 11.36 TNF IL6 CXCL8
32 11.34 TNF IL6
33 11.29 IL6 CXCR1 CXCL8
34 11.26 TNF IL6 CXCL8 CCR2
35 11.24 TNF IL6
36 11.24 TNF IL6 CXCL8
37 11.21 TNF IL6
38 11.2 IL6 CXCL8
39 11.17 TNF IL6
40 11.15 TNF IL6
41 11.11 TNF IL6
42 11.03 TNF CXCL8
43 10.98 TNF IL6
44 10.95 TNF IL6 CXCL8 CCR2
45 10.78 TNF IL6 CXCL8

GO Terms for Idiopathic Anterior Uveitis

Biological processes related to Idiopathic Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 chemotaxis GO:0006935 9.69 CXCR1 CXCL8 CCR2
2 regulation of inflammatory response GO:0050727 9.63 TNF IL37 CCR2
3 negative regulation of fat cell differentiation GO:0045599 9.62 TNF IL6
4 positive regulation of interferon-gamma production GO:0032729 9.61 TNF CCR2
5 monocyte chemotaxis GO:0002548 9.61 IL6 CCR2
6 calcium-mediated signaling GO:0019722 9.61 CXCR1 CXCL8 CCR2
7 receptor internalization GO:0031623 9.6 CXCR1 CXCL8
8 positive regulation of JAK-STAT cascade GO:0046427 9.59 TNF IL6
9 negative regulation of neurogenesis GO:0050768 9.58 TNF IL6
10 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.58 TNF IL6
11 chemokine-mediated signaling pathway GO:0070098 9.58 CXCR1 CXCL8 CCR2
12 positive regulation of chemokine production GO:0032722 9.57 TNF IL6
13 positive regulation of glial cell proliferation GO:0060252 9.56 TNF IL6
14 cellular response to lipopolysaccharide GO:0071222 9.56 TNF IL6 IL37 CXCL8
15 embryonic digestive tract development GO:0048566 9.55 TNF CXCL8
16 inflammatory response GO:0006954 9.55 TNF IL6 IL37 CXCL8 CCR2
17 dendritic cell chemotaxis GO:0002407 9.54 CXCR1 CCR2
18 humoral immune response GO:0006959 9.54 TNF IL6 CCR2
19 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.52 TNF IL6
20 positive regulation of neuroinflammatory response GO:0150078 9.49 TNF IL6
21 negative regulation of lipid storage GO:0010888 9.48 TNF IL6
22 cytokine-mediated signaling pathway GO:0019221 9.35 TNF IL6 IL37 CXCL8 CCR2
23 regulation of vascular endothelial growth factor production GO:0010574 9.32 IL6 CCR2
24 immune response GO:0006955 9.1 TNF IL6 IL37 CXCR1 CXCL8 CCR2

Molecular functions related to Idiopathic Anterior Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine binding GO:0019956 9.32 CXCR1 CCR2
2 C-C chemokine binding GO:0019957 9.26 CXCR1 CCR2
3 C-C chemokine receptor activity GO:0016493 9.16 CXCR1 CCR2
4 chemokine receptor activity GO:0004950 8.96 CXCR1 CCR2
5 cytokine activity GO:0005125 8.92 TNF IL6 IL37 CXCL8

Sources for Idiopathic Anterior Uveitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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