MCID: IDP069
MIFTS: 23

Idiopathic Avascular Necrosis

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Idiopathic Avascular Necrosis

MalaCards integrated aliases for Idiopathic Avascular Necrosis:

Name: Idiopathic Avascular Necrosis 58
Osteochondritis Dissecans 71
Idiopathic Avn 58

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases
Rare bone diseases


External Ids:

Orphanet 58 ORPHA399307
UMLS 71 C0029421

Summaries for Idiopathic Avascular Necrosis

MalaCards based summary : Idiopathic Avascular Necrosis, also known as osteochondritis dissecans, is related to avascular necrosis and alcohol dependence. The drugs Mitogens and Fibrin Tissue Adhesive have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and neutrophil.

Related Diseases for Idiopathic Avascular Necrosis

Diseases related to Idiopathic Avascular Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 avascular necrosis 10.8
2 alcohol dependence 10.0
3 endosteal hyperostosis, autosomal dominant 10.0
4 legg-calve-perthes disease 10.0
5 osteoporosis 10.0
6 gaucher disease, type i 10.0
7 sickle cell anemia 10.0
8 bone mineral density quantitative trait locus 8 10.0
9 bone mineral density quantitative trait locus 15 10.0
10 alcohol use disorder 10.0
11 gaucher's disease 10.0
12 liver disease 10.0
13 osteochondrosis 10.0
14 osteochondritis dissecans 10.0
15 tenosynovitis 10.0
16 chronic pain 10.0
17 traumatic avascular necrosis 10.0

Graphical network of the top 20 diseases related to Idiopathic Avascular Necrosis:



Diseases related to Idiopathic Avascular Necrosis

Symptoms & Phenotypes for Idiopathic Avascular Necrosis

Drugs & Therapeutics for Idiopathic Avascular Necrosis

Drugs for Idiopathic Avascular Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Mitogens Phase 3
2 Fibrin Tissue Adhesive
3 Anesthetics, Local
4 Anesthetics

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 A Randomized, Subject-blind, Controlled Pilot Trial to Evaluate the Effectiveness and Safety of the Use of Demineralized Bone Matrix (DBX®) Versus Mosaicplasty in the Treatment of Late-Stage Osteochondritis Dissecans (OCD) of the Knee in Patients With a Mature Skeleton Withdrawn NCT01283737 Phase 4
2 A Randomised Clinical Trial Comparing a Novel Single-stage Autologous Cartilage Implantation System to Conventional Microfracture for Repair of Articular Cartilage Defects in the Knee Unknown status NCT01498029 Phase 3
3 Randomised Multi-Center Study: Microfracturing With Chondro-Gide® for the Treatment of Isolated Cartilage Defects in the Knee Project-Nr.: 10830-003 Completed NCT02993510 Phase 3
4 A Prospective, Open-label, Randomized, Concurrent Active-controlled, Longitudinal, Multicenter, Phase 3 Clinical Study of the Safety and Efficacy of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee Due to Osteochondritis Dissecans or Acute Trauma Recruiting NCT03588975 Phase 3
5 A Prospective Open-label Multi-center Study to Demonstrate the Safety and Efficacy of Cells Sheet-Autologous Chondrocyte Implantation(CS-ACI)for the Treatment of Articular Cartilage Defects Unknown status NCT01694823 Phase 1, Phase 2 CS-ACI
6 Outcome of the Knee Osteochonditis Dissecans Patiets in Kuopio University Hospital (1990-2009): A Retropective Analysis Unknown status NCT01455987
7 Evaluation of the Agili-C Bi-phasic Implant Performances in the Repair of Cartilage and Osteochondral Defects Unknown status NCT01471236
8 Repair of Articular Osteochondral Defect Unknown status NCT01409447
9 A Randomized, Controlled Clinical Trial to Evaluate the Effect on Patient Outcomes of Weight Bearing Status After Forage of Osteochondral Defects of the Ankle Unknown status NCT01405664
10 Post Market, Longitudinal Data Collection Study of Articular Cartilage Lesions in the Ankle Treated With DeNovo(R) NT Natural Tissue Graft Unknown status NCT01347892
11 Pilot Study of A One-Step Procedure for the Use of Autologous Bone Marrow Mesenchymal Stem Cells Stimulated by Proteins Scaffold to Heal Under Arthroscopy Full-Thickness Defects Articular Cartilage and Osteoarthrosis of the Knee. Unknown status NCT01159899 Early Phase 1
12 Examination and Post-operative Rehabilitation of University Athletes With Osteochondral Lesions of the Knee: A Case Series Report Completed NCT03452098
13 Meniscal Repair: A Randomized Prospective Trial of FAST-FIX vs. Meniscal Suturing Completed NCT00284661
14 Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee: Does it Help? A Clinical and Magnetic Resonance Imaging (MRI) Study. Recruiting NCT02397278 Platelet rich plasma (PRP)
15 ROCK Comprehensive Prospective Cohort for Osteochondritis Dissecans of the Knee Recruiting NCT02771496
16 Focal Cartilage Defects in the Knee -A Randomized Controlled Trial Comparing Autologous Chondrocyte Implantation With Arthroscopic Debridement Recruiting NCT02636881
17 Retro Versus Trans Articular Drilling for Juvenile Osteochondritis Dissecans of the Knee: A Multicenter, Randomized Controlled Trial Active, not recruiting NCT01754298
18 Retrospective Chart Analysis of Elbow Arthroscopy for the Treatment of Osteoarthritis, Radiocapitellar Plica, Lateral Epicondylitis or Osteochondritis Dissecans Active, not recruiting NCT03656185
19 A Randomized Trial Comparing Autologous Chondrocyte Implantation Using Collagen Membrane (ACI-C) Versus (Autologous Matrix Induced Chondrogenesis) AMIC for Repair of Cartilage Defects in the Knee Active, not recruiting NCT01458782
20 Post Market, Longitudinal Data Collection Study of DeNovo NT for Articular Cartilage Defects of the Knee Active, not recruiting NCT01329445
21 MRI Findings of Epiphyseal Growth Plate in Healthy Children Enrolling by invitation NCT03190200
22 Conjoint Analysis of Patient Preferences in Joint Interventions Enrolling by invitation NCT02664337
23 A Multicenter, Randomized, Pivotal Study to Evaluate the Safety and Efficacy of the Cartilage Autograft Implantation System (CAIS) for the Surgical Treatment of Articular Cartilage Lesions of the Knee Terminated NCT00881023
24 A Post Market Study to Evaluate the Chondrofix® Osteochondral Allograft Utilized for Treatment of Subjects With Cartilage Lesions in the Knee Terminated NCT01410136

Search NIH Clinical Center for Idiopathic Avascular Necrosis

Genetic Tests for Idiopathic Avascular Necrosis

Anatomical Context for Idiopathic Avascular Necrosis

MalaCards organs/tissues related to Idiopathic Avascular Necrosis:

40
Bone, Bone Marrow, Neutrophil, Liver

Publications for Idiopathic Avascular Necrosis

Articles related to Idiopathic Avascular Necrosis:

(show top 50) (show all 1937)
# Title Authors PMID Year
1
Open Reduction and Internal Fixation for the Treatment of Symptomatic Osteochondritis Dissecans of the Femoral Head in Patients With Sequelae of Legg-Calvé-Perthes Disease. 61
32028473 2020
2
Juvenile Osteochondritis Dissecans of the Trochlea: A Cohort Study of 34 Trochlear Lesions Associated With Sporting Activities That Load the Patellofemoral Joint. 61
32028470 2020
3
[Not a Chronic Tennis Elbow]. 61
32019453 2020
4
Description of a rare osteochondrosis lesion of the medial aspect of the distal intermediate ridge of the tibia in seven Thoroughbred horses (2008-2018). 61
32020748 2020
5
Early Results of Single-plug Autologous Osteochondral Grafting for Osteochondritis Dissecans of the Capitellum in Adolescents. 61
31923167 2020
6
Capitellar Osteochondritis Dissecans Lesions of the Elbow: A Systematic Review of Osteochondral Graft Reconstruction Options. 61
32035172 2020
7
Long-term Results of Matrix-assisted Autologous Chondrocyte Transplantation Combined With Autologous Bone Grafting for the Treatment of Juvenile Osteochondritis Dissecans. 61
31107345 2020
8
Nonoperative treatment of stable juvenile osteochondritis dissecans of the knee: effectiveness of unloader bracing. 61
31774736 2020
9
Osteochondritis Dissecans in Pediatric Patients with Juvenile Idiopathic Arthritis. 61
31941802 2020
10
Osteochondral Reconstruction of the Capitellum. 61
31739884 2020
11
Long-term Outcomes of Arthroscopic Debridement With or Without Drilling for Osteochondritis Dissecans of the Capitellum in Adolescent Baseball Players: A ≥10-year Follow-up Study. 61
32001276 2020
12
Failure of Surgery for Osteochondral Injuries of the Elbow in the Pediatric and Adolescent Population. 61
31950429 2020
13
Synovial sepsis of unknown origin in the adult Thoroughbred racehorse. 61
31006125 2020
14
A novel autologous-made matrix using hyaline cartilage chips and platelet-rich growth factors for the treatment of full-thickness cartilage or osteochondral defects: Preliminary results. 61
31835970 2020
15
Health State Utilities in Children and Adolescents With Osteochondritis Dissecans of the Knee. 61
31840031 2019
16
Condylar Destruction in an 8-Year-Old Girl After Osteochondritis Dissecans. 61
31931954 2019
17
Epidemiology, Injury Patterns, and Treatment of Meniscal Tears in Pediatric Patients: A 16-Year Experience of a Single Center. 61
31903403 2019
18
Therapeutic mesenchymal stromal stem cells: Isolation, characterization and role in equine regenerative medicine and metabolic disorders. 61
31797146 2019
19
The Influence of Physeal Status on Rate of Reoperation After Arthroscopic Screw Fixation for Symptomatic Osteochondritis Dissecans of the Knee. 61
31870748 2019
20
Analysis of congruence for talar dome geometry among tali of different sizes. 61
31704589 2019
21
Osteochondritis Dissecans of the Elbow in Children: MRI Findings of Instability. 61
31461319 2019
22
The Treatment of Adult Osteochondritis Dissecans with Autologous Cartilage Implantation: A Systematic Review. 61
30396204 2019
23
Management of loose osteochondritis dissecans in an adolescent. 61
31708639 2019
24
Association of IL-6 -174G > C and -572G > C Polymorphisms with Risk of Legg-Calve-Perthes Disease in Iranian Children. 61
31757175 2019
25
[Differential diagnoses of osteonecrosis of large joints]. 61
31642951 2019
26
Vitamin D Deficiency in Patients With Idiopathic and Traumatic Osteochondritis Dissecans of the Talus. 61
31370694 2019
27
Histologic Analysis of 2 Alternative Donor Sites of the Ipsilateral Elbow in the Treatment of Capitellar Osteochondritis Dissecans. 61
31699253 2019
28
Editorial Commentary: "Elbow-to-Elbow" Capitellar Osteochondral Autologous Transplantation for Osteochondritis Dissecans-Are We Closer to the Holy Grail of Osteochondral Graft? 61
31699254 2019
29
Internal Fixation of Osteochondritis Dissecans of the Knee Leads to Good Long-Term Outcomes and High Degree of Healing without Differences between Fixation Devices. 61
31717628 2019
30
Biomechanical modeling of deep squatting: Effects of the interface contact between posterior thigh and shank. 61
31558308 2019
31
Plica Syndrome and Bilateral Osteochondritis Dissecans. 61
31570077 2019
32
Arthroscopic Fixation of Osteochondritis Dissecans of the Knee Using a Motorized Pick and Headless Compression Screws. 61
31921583 2019
33
[HYBRID OSTEOCHONDRAL TRANSPLANTATION - A NEW METHOD FOR SURGICAL TREATMENT OF OSTEOCHONDRITIS DISSECANS OF THE KNEE JOINT]. 61
31804190 2019
34
Evaluation of the Suitability of Miniature Pigs as an Animal Model of Juvenile Osteochondritis Dissecans. 61
31115932 2019
35
Donor Site Evaluation After Osteochondral Autograft Transplantation for Capitellar Osteochondritis Dissecans. 61
31503508 2019
36
Encouraging mid-term outcomes for arthroscopic autologous osteochondral transplant (OAT) in capitellum osteochondritis dissecans (OCD). 61
31236634 2019
37
What are the prevalence and risk factors for repeat ipsilateral knee arthroscopy? 61
30656373 2019
38
Utility of Bioabsorbable Fixation of Osteochondral Lesions in the Adolescent Knee: Outcomes Analysis With Minimum 2-Year Follow-up. 61
31696131 2019
39
Allogenic umbilical cord blood-derived mesenchymal stem cells implantation for the treatment of juvenile osteochondritis dissecans of the knee. 61
31700204 2019
40
Predictive factors for developing osteochondritis dissecans after surgery for discoid lateral meniscus are younger age and shorter meniscal width. 61
31642945 2019
41
Closed-Wedge Osteotomy of the Distal Humerus for Treating Osteochondritis Dissecans of the Capitellum in Young Patients. 61
31696130 2019
42
Predictors of Unsuccessful Nonoperative Management of Capitellar Osteochondritis Dissecans. 61
31348868 2019
43
Qafzeh 9 mandible (ca 90-100 kyrs BP, Israel) revisited: μ-CT and 3D reveal new pathological conditions. 61
31351220 2019
44
Injury Risk Associated With Sports Specialization and Activity Volume in Youth. 61
31555716 2019
45
Long-term results of closed-wedge osteotomy of the lateral humeral condyle for osteochondritis dissecans of the capitellum. 61
31326338 2019
46
Early Clinical Results of Arthroscopically Assisted Drilling via the Radius in a Distal-to-Proximal Direction for Osteochondritis Dissecans of the Elbow. 61
31523694 2019
47
Effectiveness of Adhering Adipose-Derived Stem Cells to Defective Cartilage in Promoting Cartilage Regeneration in a Rabbit Model. 61
31307837 2019
48
Avascular necrosis of the capitate: case series of five patients and review of literature. 61
31142182 2019
49
[Differential diagnoses of osteonecrosis of large joints]. 61
31317211 2019
50
Osteochondritis dissecans with associated secondary chondromatosis in an adolescent shoulder. 61
31316588 2019

Variations for Idiopathic Avascular Necrosis

Expression for Idiopathic Avascular Necrosis

Search GEO for disease gene expression data for Idiopathic Avascular Necrosis.

Pathways for Idiopathic Avascular Necrosis

GO Terms for Idiopathic Avascular Necrosis

Sources for Idiopathic Avascular Necrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....