MCID: IDP069
MIFTS: 23

Idiopathic Avascular Necrosis

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Idiopathic Avascular Necrosis

MalaCards integrated aliases for Idiopathic Avascular Necrosis:

Name: Idiopathic Avascular Necrosis 58
Osteochondritis Dissecans 71
Idiopathic Avn 58

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases
Rare bone diseases


External Ids:

ICD10 via Orphanet 33 M87.0
Orphanet 58 ORPHA399307
UMLS 71 C0029421

Summaries for Idiopathic Avascular Necrosis

MalaCards based summary : Idiopathic Avascular Necrosis, also known as osteochondritis dissecans, is related to avascular necrosis and alcohol dependence. The drugs Fibrin Tissue Adhesive and Mitogens have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and neutrophil.

Related Diseases for Idiopathic Avascular Necrosis

Diseases related to Idiopathic Avascular Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 avascular necrosis 10.8
2 alcohol dependence 10.0
3 endosteal hyperostosis, autosomal dominant 10.0
4 legg-calve-perthes disease 10.0
5 osteoporosis 10.0
6 gaucher disease, type i 10.0
7 sickle cell anemia 10.0
8 bone mineral density quantitative trait locus 8 10.0
9 bone mineral density quantitative trait locus 15 10.0
10 alcohol use disorder 10.0
11 gaucher's disease 10.0
12 liver disease 10.0
13 osteochondrosis 10.0
14 osteochondritis dissecans 10.0
15 tenosynovitis 10.0
16 chronic pain 10.0
17 traumatic avascular necrosis 10.0

Graphical network of the top 20 diseases related to Idiopathic Avascular Necrosis:



Diseases related to Idiopathic Avascular Necrosis

Symptoms & Phenotypes for Idiopathic Avascular Necrosis

Drugs & Therapeutics for Idiopathic Avascular Necrosis

Drugs for Idiopathic Avascular Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fibrin Tissue Adhesive Phase 3
2 Mitogens Phase 3
3 Astragalus
4 Anesthetics
5 Anesthetics, Local

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 A Randomized, Subject-blind, Controlled Pilot Trial to Evaluate the Effectiveness and Safety of the Use of Demineralized Bone Matrix (DBX®) Versus Mosaicplasty in the Treatment of Late-Stage Osteochondritis Dissecans (OCD) of the Knee in Patients With a Mature Skeleton Withdrawn NCT01283737 Phase 4
2 A Randomised Clinical Trial Comparing a Novel Single-stage Autologous Cartilage Implantation System to Conventional Microfracture for Repair of Articular Cartilage Defects in the Knee Unknown status NCT01498029 Phase 3
3 Randomised Multi-Center Study: Microfracturing With Chondro-Gide® for the Treatment of Isolated Cartilage Defects in the Knee Project-Nr.: 10830-003 Completed NCT02993510 Phase 3
4 A Prospective, Open-label, Randomized, Concurrent Active-controlled, Longitudinal, Multicenter, Phase 3 Clinical Study of the Safety and Efficacy of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee Due to Osteochondritis Dissecans or Acute Trauma Recruiting NCT03588975 Phase 3
5 A Prospective Open-label Multi-center Study to Demonstrate the Safety and Efficacy of Cells Sheet-Autologous Chondrocyte Implantation(CS-ACI)for the Treatment of Articular Cartilage Defects Unknown status NCT01694823 Phase 1, Phase 2 CS-ACI
6 Outcome of the Knee Osteochonditis Dissecans Patiets in Kuopio University Hospital (1990-2009): A Retropective Analysis Unknown status NCT01455987
7 Repair of Articular Osteochondral Defect Unknown status NCT01409447
8 A Randomized, Controlled Clinical Trial to Evaluate the Effect on Patient Outcomes of Weight Bearing Status After Forage of Osteochondral Defects of the Ankle Unknown status NCT01405664
9 Post Market, Longitudinal Data Collection Study of Articular Cartilage Lesions in the Ankle Treated With DeNovo(R) NT Natural Tissue Graft Unknown status NCT01347892
10 Pilot Study of A One-Step Procedure for the Use of Autologous Bone Marrow Mesenchymal Stem Cells Stimulated by Proteins Scaffold to Heal Under Arthroscopy Full-Thickness Defects Articular Cartilage and Osteoarthrosis of the Knee. Unknown status NCT01159899 Early Phase 1
11 Evaluation of the Agili-C Bi-phasic Implant Performances in the Repair of Cartilage and Osteochondral Defects Completed NCT01471236
12 Examination and Post-operative Rehabilitation of University Athletes With Osteochondral Lesions of the Knee: A Case Series Report Completed NCT03452098
13 Meniscal Repair: A Randomized Prospective Trial of FAST-FIX vs. Meniscal Suturing Completed NCT00284661
14 Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee: Does it Help? A Clinical and Magnetic Resonance Imaging (MRI) Study. Recruiting NCT02397278 Platelet rich plasma (PRP)
15 Prospective 2-year Data Collection of the First 10 Patients After Ankle Spacer Recruiting NCT04297449
16 Collecting Diagnostic, Treatment and Follow-up Data on Knee Treatments. Recruiting NCT04364334
17 Biological Effects of a Bipolar Radiofrequency-based Device Over Shoulder Cartilage - a Randomized Controlled Clinical Trial Recruiting NCT04309344
18 Focal Cartilage Defects in the Knee -A Randomized Controlled Trial Comparing Autologous Chondrocyte Implantation With Arthroscopic Debridement Recruiting NCT02636881
19 Retro Versus Trans Articular Drilling for Juvenile Osteochondritis Dissecans of the Knee: A Multicenter, Randomized Controlled Trial Active, not recruiting NCT01754298
20 Retrospective Chart Analysis of Elbow Arthroscopy for the Treatment of Osteoarthritis, Radiocapitellar Plica, Lateral Epicondylitis or Osteochondritis Dissecans Active, not recruiting NCT03656185
21 ROCK Comprehensive Prospective Cohort for Osteochondritis Dissecans of the Knee Active, not recruiting NCT02771496
22 A Randomized Trial Comparing Autologous Chondrocyte Implantation Using Collagen Membrane (ACI-C) Versus (Autologous Matrix Induced Chondrogenesis) AMIC for Repair of Cartilage Defects in the Knee Active, not recruiting NCT01458782
23 Post Market, Longitudinal Data Collection Study of DeNovo NT for Articular Cartilage Defects of the Knee Active, not recruiting NCT01329445
24 MRI Findings of Epiphyseal Growth Plate in Healthy Children Enrolling by invitation NCT03190200
25 Prospective Randomized Controlled Study Utilizing the Stryker Hip-Check Software Platform Not yet recruiting NCT04265222
26 Conjoint Analysis of Patient Preferences in Joint Interventions Suspended NCT02664337
27 A Multicenter, Randomized, Pivotal Study to Evaluate the Safety and Efficacy of the Cartilage Autograft Implantation System (CAIS) for the Surgical Treatment of Articular Cartilage Lesions of the Knee Terminated NCT00881023
28 A Post Market Study to Evaluate the Chondrofix® Osteochondral Allograft Utilized for Treatment of Subjects With Cartilage Lesions in the Knee Terminated NCT01410136

Search NIH Clinical Center for Idiopathic Avascular Necrosis

Genetic Tests for Idiopathic Avascular Necrosis

Anatomical Context for Idiopathic Avascular Necrosis

MalaCards organs/tissues related to Idiopathic Avascular Necrosis:

40
Bone, Bone Marrow, Neutrophil

Publications for Idiopathic Avascular Necrosis

Articles related to Idiopathic Avascular Necrosis:

(show top 50) (show all 1959)
# Title Authors PMID Year
1
Aggrecanopathies highlight the need for genetic evaluation of ISS children. 61
32413843 2020
2
Osteochondritis Dissecans of the Knee: Etiology and Pathogenetic Mechanisms. A Systematic Review. 61
29998741 2020
3
Osteochondritis Dissecans of the Knee: Short-Term Outcomes of a Hybrid Technique to Restore a Partially Salvageable Progeny Fragment. 61
30141694 2020
4
Osteochondritis Dissecans in the Knee of Skeletally Immature Patients: Rates of Persistent Pain, Osteoarthritis, and Arthroplasty at Mean 14-Years' Follow-Up. 61
29998745 2020
5
Fresh Precut Osteochondral Allograft Core Transplantation for the Treatment of Capitellum Osteochondritis Dissecans. 61
32577354 2020
6
Capitellar Osteochondritis Dissecans Lesions of the Elbow: A Systematic Review of Osteochondral Graft Reconstruction Options. 61
32035172 2020
7
Advances in Sports Medicine and Care of the Adolescent Athlete. 61
32389257 2020
8
Description of a rare osteochondrosis lesion of the medial aspect of the distal intermediate ridge of the tibia in seven Thoroughbred horses (2008-2018). 61
32020748 2020
9
Editorial Commentary: Should We Consider Early Retirement for Adolescent Pitchers and Catchers With Osteochonditis Dissecans of the Capitellum? 61
32370890 2020
10
Long-Term Outcomes of Arthroscopic Debridement With or Without Drilling for Osteochondritis Dissecans of the Capitellum in Adolescent Baseball Players: A ≥10-Year Follow-Up Study. 61
32001276 2020
11
Biomechanical Changes of Repair Tissue after Autologous Chondrocyte Implantation at Long-Term Follow-Up. 61
32447977 2020
12
Idiopathic Avascular Necrosis of Trapezoid in Adolescence: 3-Year Follow-Up. 61
30733102 2020
13
Autologous Chondrocyte Implantation as Treatment for Unsalvageable Osteochondritis Dissecans: 10- to 25-Year Follow-up. 61
32181674 2020
14
All-Arthroscopic Osteochondral Autograft Transfer Technique for Osteochondritis Dissecans of the Talus. 61
32368470 2020
15
Technique for Arthroscopic Debridement and Microfracture of Unstable, Contained Osteochondritis Dissecans Lesions of the Capitellum. 61
32368475 2020
16
A Staged Arthroscopic Approach to Fixation of Unstable Osteochondritis Dissecans in the Medial Femoral Condyle of the Knee Using Nonabsorbable Fixation Screws. 61
32368467 2020
17
Management of the Failed OCD. 61
32147780 2020
18
Therapeutic mesenchymal stromal stem cells: Isolation, characterization and role in equine regenerative medicine and metabolic disorders. 61
31797146 2020
19
MRI evaluation of articular cartilage in patients with juvenile osteochondritis dissecans (JOCD) using T2∗ mapping at 3T. 61
32278071 2020
20
Osteochondritis Dissecans Lesion Location Is Highly Concordant With Mechanical Axis Deviation. 61
32167842 2020
21
Editorial Commentary: Osteochondritis Dissecans of the Knee: The Great Confounder. 61
32139056 2020
22
Osteochondritis Dissecans in Pediatric Patients with Juvenile Idiopathic Arthritis. 61
31941802 2020
23
Open Reduction and Internal Fixation for the Treatment of Symptomatic Osteochondritis Dissecans of the Femoral Head in Patients With Sequelae of Legg-Calvé-Perthes Disease. 61
32028473 2020
24
The Influence of Physeal Status on Rate of Reoperation After Arthroscopic Screw Fixation for Symptomatic Osteochondritis Dissecans of the Knee. 61
31870748 2020
25
Erratum to "Closed-Wedge Osteotomy of the Distal Humerus for Treating Osteochondritis Dissecans of the Capitellum in Young Patients". 61
32284942 2020
26
A case report of osteochondritis dissecans of the first metatarsophalangeal joint treated with autologous cancellous bone and chondral flap reconstruction. 61
32153761 2020
27
Juvenile Osteochondritis Dissecans of the Trochlea: A Cohort Study of 34 Trochlear Lesions Associated With Sporting Activities That Load the Patellofemoral Joint. 61
32028470 2020
28
Early Radiographic Healing and Functional Results After Autologous Osteochondral Grafting for Osteochondritis Dissecans of the Capitellum: Introduction of a New Magnetic Resonance Imaging-Based Scoring System. 61
32053395 2020
29
Measuring Knee Bone Marrow Perfusion Using Arterial Spin Labeling at 3 T. 61
32210271 2020
30
[Not a Chronic Tennis Elbow]. 61
32019453 2020
31
Osteochondritis dissecans of the glenoid in gymnasts: Report of two cases. 61
32107134 2020
32
Early Results of Single-plug Autologous Osteochondral Grafting for Osteochondritis Dissecans of the Capitellum in Adolescents. 61
31923167 2020
33
Long-term Results of Matrix-assisted Autologous Chondrocyte Transplantation Combined With Autologous Bone Grafting for the Treatment of Juvenile Osteochondritis Dissecans. 61
31107345 2020
34
Failure of Surgery for Osteochondral Injuries of the Elbow in the Pediatric and Adolescent Population. 61
31950429 2020
35
Nonoperative treatment of stable juvenile osteochondritis dissecans of the knee: effectiveness of unloader bracing. 61
31774736 2020
36
Matrix induced autologous chondrocyte implantation in the knee: Comparison between osteochondritis dissecans and osteonecrosis and effect of chondrocyte thickness on prognosis. 61
32175899 2020
37
Contralateral Lateral Femoral Condyle Allografts Provide an Acceptable Surface Match for Simulated Classic Osteochondritis Dissecans Lesions of the Medial Femoral Condyle. 61
32064295 2020
38
Osteochondral Reconstruction of the Capitellum. 61
31739884 2020
39
Synovial sepsis of unknown origin in the adult Thoroughbred racehorse. 61
31006125 2020
40
A triplanar osteotomy technique in arthroscopy-assisted ankle mosaicplasty. 61
32189573 2020
41
A novel autologous-made matrix using hyaline cartilage chips and platelet-rich growth factors for the treatment of full-thickness cartilage or osteochondral defects: Preliminary results. 61
31835970 2020
42
Health State Utilities in Children and Adolescents With Osteochondritis Dissecans of the Knee. 61
31840031 2019
43
Condylar Destruction in an 8-Year-Old Girl After Osteochondritis Dissecans. 61
31931954 2019
44
Epidemiology, Injury Patterns, and Treatment of Meniscal Tears in Pediatric Patients: A 16-Year Experience of a Single Center. 61
31903403 2019
45
Analysis of congruence for talar dome geometry among tali of different sizes. 61
31704589 2019
46
Osteochondritis Dissecans of the Elbow in Children: MRI Findings of Instability. 61
31461319 2019
47
The Treatment of Adult Osteochondritis Dissecans with Autologous Cartilage Implantation: A Systematic Review. 61
30396204 2019
48
Management of loose osteochondritis dissecans in an adolescent. 61
31708639 2019
49
[Differential diagnoses of osteonecrosis of large joints]. 61
31642951 2019
50
Vitamin D Deficiency in Patients With Idiopathic and Traumatic Osteochondritis Dissecans of the Talus. 61
31370694 2019

Variations for Idiopathic Avascular Necrosis

Expression for Idiopathic Avascular Necrosis

Search GEO for disease gene expression data for Idiopathic Avascular Necrosis.

Pathways for Idiopathic Avascular Necrosis

GO Terms for Idiopathic Avascular Necrosis

Sources for Idiopathic Avascular Necrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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