MCID: IDP069
MIFTS: 23

Idiopathic Avascular Necrosis

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Idiopathic Avascular Necrosis

MalaCards integrated aliases for Idiopathic Avascular Necrosis:

Name: Idiopathic Avascular Necrosis 58
Osteochondritis Dissecans 70
Idiopathic Avn 58

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases
Rare bone diseases


External Ids:

ICD10 via Orphanet 33 M87.0
Orphanet 58 ORPHA399307
UMLS 70 C0029421

Summaries for Idiopathic Avascular Necrosis

MalaCards based summary : Idiopathic Avascular Necrosis, also known as osteochondritis dissecans, is related to avascular necrosis and alcohol dependence. The drugs Fibrin Tissue Adhesive and Mitogens have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and neutrophil.

Related Diseases for Idiopathic Avascular Necrosis

Diseases related to Idiopathic Avascular Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 avascular necrosis 10.8
2 alcohol dependence 10.0
3 legg-calve-perthes disease 10.0
4 osteoporosis 10.0
5 sickle cell anemia 10.0
6 bone mineral density quantitative trait locus 8 10.0
7 bone mineral density quantitative trait locus 15 10.0
8 alcohol use disorder 10.0
9 gaucher's disease 10.0
10 osteochondrosis 10.0
11 osteochondritis dissecans 10.0
12 tenosynovitis 10.0
13 traumatic avascular necrosis 10.0

Graphical network of the top 20 diseases related to Idiopathic Avascular Necrosis:



Diseases related to Idiopathic Avascular Necrosis

Symptoms & Phenotypes for Idiopathic Avascular Necrosis

Drugs & Therapeutics for Idiopathic Avascular Necrosis

Drugs for Idiopathic Avascular Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fibrin Tissue Adhesive Phase 3
2 Mitogens Phase 3
3 Astragalus

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 A Randomized, Subject-blind, Controlled Pilot Trial to Evaluate the Effectiveness and Safety of the Use of Demineralized Bone Matrix (DBX®) Versus Mosaicplasty in the Treatment of Late-Stage Osteochondritis Dissecans (OCD) of the Knee in Patients With a Mature Skeleton Withdrawn NCT01283737 Phase 4
2 A Randomised Clinical Trial Comparing a Novel Single-stage Autologous Cartilage Implantation System to Conventional Microfracture for Repair of Articular Cartilage Defects in the Knee Unknown status NCT01498029 Phase 3
3 Randomised Multi-Center Study: Microfracturing With Chondro-Gide® for the Treatment of Isolated Cartilage Defects in the Knee Project-Nr.: 10830-003 Completed NCT02993510 Phase 3
4 A Prospective, Open-label, Randomized, Concurrent Active-controlled, Longitudinal, Multicenter, Phase 3 Clinical Study of the Safety and Efficacy of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee Due to Osteochondritis Dissecans or Acute Trauma Recruiting NCT03588975 Phase 3
5 A Prospective Open-label Multi-center Study to Demonstrate the Safety and Efficacy of Cells Sheet-Autologous Chondrocyte Implantation(CS-ACI)for the Treatment of Articular Cartilage Defects Unknown status NCT01694823 Phase 1, Phase 2 CS-ACI
6 Outcome of the Knee Osteochonditis Dissecans Patiets in Kuopio University Hospital (1990-2009): A Retropective Analysis Unknown status NCT01455987
7 Repair of Articular Osteochondral Defect Unknown status NCT01409447
8 Pilot Study of A One-Step Procedure for the Use of Autologous Bone Marrow Mesenchymal Stem Cells Stimulated by Proteins Scaffold to Heal Under Arthroscopy Full-Thickness Defects Articular Cartilage and Osteoarthrosis of the Knee. Unknown status NCT01159899 Early Phase 1
9 Post Market, Longitudinal Data Collection Study of Articular Cartilage Lesions in the Ankle Treated With DeNovo(R) NT Natural Tissue Graft Unknown status NCT01347892
10 Evaluation of the Agili-C Bi-phasic Implant Performances in the Repair of Cartilage and Osteochondral Defects Completed NCT01471236
11 Retro Versus Trans Articular Drilling for Juvenile Osteochondritis Dissecans of the Knee: A Multicenter, Randomized Controlled Trial Completed NCT01754298
12 Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee: Does it Help? A Clinical and Magnetic Resonance Imaging (MRI) Study. Completed NCT02397278 Platelet rich plasma (PRP)
13 Examination and Post-operative Rehabilitation of University Athletes With Osteochondral Lesions of the Knee: A Case Series Report Completed NCT03452098
14 Psychological Response and Readiness to Return to Sports Associated With the Diagnosis and Treatment of Osteochondritis Dissecans of the Knee Recruiting NCT04649905
15 A Randomized, Controlled Clinical Trial to Evaluate the Effect on Patient Outcomes of Weight Bearing Status After Forage of Osteochondral Defects of the Ankle Recruiting NCT01405664
16 Prospective 2-year Data Collection of the First 10 Patients After Ankle Spacer Recruiting NCT04297449
17 Collecting Diagnostic, Treatment and Follow-up Data on Knee Treatments. Recruiting NCT04364334
18 ROCK Comprehensive Prospective Cohort for Osteochondritis Dissecans of the Knee Active, not recruiting NCT02771496
19 Retrospective Chart Analysis of Elbow Arthroscopy for the Treatment of Osteoarthritis, Radiocapitellar Plica, Lateral Epicondylitis or Osteochondritis Dissecans Active, not recruiting NCT03656185
20 A Randomized Trial Comparing Autologous Chondrocyte Implantation Using Collagen Membrane (ACI-C) Versus (Autologous Matrix Induced Chondrogenesis) AMIC for Repair of Cartilage Defects in the Knee Active, not recruiting NCT01458782
21 Post Market, Longitudinal Data Collection Study of DeNovo NT for Articular Cartilage Defects of the Knee Active, not recruiting NCT01329445
22 MRI Findings of Epiphyseal Growth Plate in Healthy Children Enrolling by invitation NCT03190200
23 Conjoint Analysis of Patient Preferences in Joint Interventions Suspended NCT02664337
24 A Multicenter, Randomized, Pivotal Study to Evaluate the Safety and Efficacy of the Cartilage Autograft Implantation System (CAIS) for the Surgical Treatment of Articular Cartilage Lesions of the Knee Terminated NCT00881023

Search NIH Clinical Center for Idiopathic Avascular Necrosis

Genetic Tests for Idiopathic Avascular Necrosis

Anatomical Context for Idiopathic Avascular Necrosis

MalaCards organs/tissues related to Idiopathic Avascular Necrosis:

40
Bone, Bone Marrow, Neutrophil

Publications for Idiopathic Avascular Necrosis

Articles related to Idiopathic Avascular Necrosis:

(show top 50) (show all 2025)
# Title Authors PMID Year
1
Tennis overuse injuries in the upper extremity. 61
33009583 2021
2
Validity of Ultrasound Compared with Magnetic Resonance Imaging in Evaluation of Osteochondritis Dissecans of the Distal Femur in Children. 61
30704293 2021
3
Comparison Between Osteochondral Autograft Transplantation and Arthroscopic Fragment Resection for Large Capitellar Osteochondritis Dissecans in Adolescent Athletes: A Minimum 5 Years' Follow-up. 61
33705216 2021
4
A Modification of the Cheli Craniolateral Approach for Minimally Invasive Treatment of Osteochondritis Dissecans of the Shoulder in Dogs: Description of the Technique and Outcome in 164 Cases. 61
33232983 2021
5
Magnetic Resonance Imaging in Osteochondritis Dissecans of the Humeral Capitellum: Preoperative Assessment of Lesion Size and Lateral Wall Integrity. 61
33795154 2021
6
Prevalence of hypovitaminosis D in patients with juvenile osteochondritis dissecans. 61
33281101 2021
7
Novel Magnetic Resonance Imaging Classification of Osteochondritis Dissecans of the Knee: A Reliability Study. 61
33782366 2021
8
Canine Elbow Dysplasia: Ununited Anconeal Process, Osteochondritis Dissecans, and Medial Coronoid Process Disease. 61
33558015 2021
9
Internal Fixation of Osteochondritis Dissecans Using PushLock Suture Anchors. 61
33738205 2021
10
Overuse Elbow Injuries in Youth Gymnasts. 61
33780632 2021
11
Safety and performance of biodegradable magnesium-based implants in children and adolescents. 61
33775413 2021
12
Limiting the Pitch Count in Youth Baseball Pitchers Decreases Elbow Pain. 61
33796588 2021
13
Prevalence and Severity of Juvenile Osteochondritis Dissecans in Patients With Juvenile Idiopathic Arthritis. 61
33718500 2021
14
Osteochondral autograft transplantation versus autologous bone-cartilage paste grafting for the treatment of knee osteochondritis dissecans. 61
32959150 2021
15
Ankle Morphology and Juvenile Osteochondritis Dissecans (JOCD) of the Talus: Is There an Association? An MRI Study. 61
33229961 2021
16
A high rate of children and adolescents return to sport after surgical treatment of osteochondritis dissecans of the elbow: a systematic review and meta-analysis. 61
33620512 2021
17
Predictors of Failure of Return to Play in Youth Baseball Players After Capitellar Osteochondritis Dissecans: Focus on Elbow Valgus Laxity and Radiocapitellar Congruity. 61
33321050 2021
18
The nonoperative treatment of osteochondritis dissecans of the knee. 61
33315689 2021
19
Editorial Commentary: Early Operative Management of "Stable" Osteochondritis Dissecans Lesions Confers Greater Value in Skeletally Immature Patients. 61
33546800 2021
20
Cost-Effectiveness Analysis of Nonoperative Management Versus Early Drilling for Stable Osteochondritis Dissecans Lesions of the Knee in Skeletally Immature Patients. 61
33271176 2021
21
The Use of Elbow Arthroscopy for Management of the Pediatric Elbow: A Systematic Review of Indications and Outcomes. 61
33539972 2021
22
Lateral wall fixation with bone pegs for advanced osteochondritis dissecans of the humeral capitellum. 61
33554161 2021
23
Performance of PROMIS Scores Compared to Legacy Metrics in Evaluating Outcomes after Surgical Treatment for Osteochondritis Dissecans of the Humeral Capitellum. 61
33486062 2021
24
Management of bilateral osteochondritis dissecans of the trochlea in a skeletally immature patient. 61
33504536 2021
25
A novel three-dimensional MRI-CT image fusion technique for precise preoperative evaluation and treatment of capitellar osteochondritis dissecans. 61
33454801 2021
26
Evaluation and Surgical Management of Knee Osteochondritis Dissecans and Adolescent Cartilage Injuries. 61
33438925 2021
27
What's New in Osteochondritis Dissecans of the Knee, Elbow, and Ankle. 61
33438926 2021
28
Multiple Osteochondritis Dissecans in Multiple Joints. 61
33575051 2021
29
Predictive factors for developing osteochondritis dissecans after surgery for discoid lateral meniscus are younger age and shorter meniscal width. 61
31642945 2021
30
Progression of Epiphyseal Cartilage and Bone Pathology in Surgically Treated Cases of Osteochondritis Dissecans of the Elbow. 61
33196301 2021
31
Osteochondral Lesions of the Talus: A Review on Talus Osteochondral Injuries, Including Osteochondritis Dissecans. 61
33423507 2021
32
Surgical Fixation of Chondral-Only Fragments of the Knee: A Case Series With a Mean 4-Year Follow-up. 61
33521156 2021
33
A novel mutation in the ACAN gene in a family with autosomal dominant short stature and intervertebral disc disease. 61
33298914 2020
34
Dual diagnosis of osteogenesis imperfecta (OI) and short stature and advanced bone age with or without early-onset osteoarthritis and/or osteochondritis dissecans (SSOAOD) reveals a cumulative effect on stature caused by mutations in COL1A1 and ACAN genes. 61
32980524 2020
35
The incidence and risk factors of osteoarthritis following osteochondritis dissecans of the knees: a systematic review and meta-analysis. 61
33211214 2020
36
Bioabsorbable Unsintered Hydroxyapatite/Poly-l-Lactic Acid Pin Fixation of Osteochondritis Dissecans in Adolescents: Initial Experiences. 61
33233012 2020
37
Radiography and Standing Computed Tomography of an Osteochondritis Dissecans Lesion Found at the Dorsodistolateral Aspect of the Calcaneus in a 3-Year-Old Horse. 61
33077099 2020
38
Overuse Knee Pain in the Pediatric and Adolescent Athlete. 61
33156034 2020
39
Open Treatment for Unstable Osteochondritis Dissecans of the Knee: Autologous Bone Grafting and Bioabsorbable Fixation. 61
33294340 2020
40
Risk factors for hospital admission in patients undergoing outpatient anterior cruciate ligament reconstruction: A national database study. 61
33071518 2020
41
Clinical and Radiographic Outcomes After Fixation of Chondral Fragments of the Knee in 6 Adolescents Using Autologous Bone Pegs. 61
33457431 2020
42
Osteochondral Autograft Transfer for Capitellar Chondral and Osteochondral Defects. 61
33294333 2020
43
Factors Related to Postoperative Osteochondritis Dissecans of the Lateral Femoral Condyle After Meniscal Surgery in Juvenile Patients With a Discoid Lateral Meniscus. 61
32658153 2020
44
Osteochondritis Dissecans of the Lateral Process of Talus Involving the Subtalar Joint: An Unusual Case. 61
33509717 2020
45
Satisfaction With Elbow Function and Return Status After Autologous Osteochondral Transplant for Capitellar Osteochondritis Dissecans in High School Baseball Players. 61
32941055 2020
46
Arthroscopic Meniscopexy for the Treatment of Nontraumatic Osteochondritis Dissecans in the Knee Joint of Adult Patients. 61
30221986 2020
47
Is There a Role for Ultrasound in Hip Arthroscopy? A Systematic Review. 61
33135007 2020
48
MRI evaluation of articular cartilage in patients with juvenile osteochondritis dissecans (JOCD) using T2∗ mapping at 3T. 61
32278071 2020
49
Treatment of Juvenile Knee Osteochondritis Dissecans with a Cell-Free Biomimetic Osteochondral Scaffold: Clinical and MRI Results at Mid-Term Follow-up. 61
32909451 2020
50
Shoulder and Elbow Injuries in the Adolescent Throwing Athlete. 61
32872686 2020

Variations for Idiopathic Avascular Necrosis

Expression for Idiopathic Avascular Necrosis

Search GEO for disease gene expression data for Idiopathic Avascular Necrosis.

Pathways for Idiopathic Avascular Necrosis

GO Terms for Idiopathic Avascular Necrosis

Sources for Idiopathic Avascular Necrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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