MCID: IDP001
MIFTS: 27

Idiopathic Cd4-Positive T-Lymphocytopenia

Categories: Blood diseases, Immune diseases, Rare diseases

Aliases & Classifications for Idiopathic Cd4-Positive T-Lymphocytopenia

MalaCards integrated aliases for Idiopathic Cd4-Positive T-Lymphocytopenia:

Name: Idiopathic Cd4-Positive T-Lymphocytopenia 12 15 17
T-Lymphocytopenia, Idiopathic Cd4-Positive 45 74
Immunodeficiency 13 54 74
Idiopathic Cd4 Positive T-Lymphocytopenia 54
Idiopathic Cd4 Lymphocytopenia 54
Idiopathic Cd4 Lymphopenia 54
Imd13 54
Icl 54

Classifications:



External Ids:

Disease Ontology 12 DOID:3109
MeSH 45 D018344
NCIt 51 C84780

Summaries for Idiopathic Cd4-Positive T-Lymphocytopenia

NIH Rare Diseases : 54 Idiopathic CD4 positive T-lymphocytopenia (ICL) is a rare disorder of the immune system. People with ICL have low levels of a type of white blood cell, called a CD4+ T cell. These low levels can not be explained by other causes of immunodeficiency, including HIV infection. T cells have many jobs in our immune system, such as attacking bacteria and viruses. CD4 is a protein found on the surface of many different cells within your immune system. It lets the different cells of your immune system work with each other. When CD4+ T cells are decreased, your body becomes more prone to infection. Signs and Symptoms of ICL vary. Some people have no symptoms, however most have illnesses suggestive of a lowered immune system, including infections (varicella-zoster virus, human papilloma virus), autoimmune disorders (autoimmune hemolytic anemia, lupus), and certain types of cancer (non-Hodgkin lymphoma). A few people with ICL are found to carry specific genemutations; however, for most cases of ICL the underlying cause is not known. Currently, there is no cure for ICL, but treatments are available to help manage individual symptoms.

MalaCards based summary : Idiopathic Cd4-Positive T-Lymphocytopenia, also known as t-lymphocytopenia, idiopathic cd4-positive, is related to immunodeficiency 13 and myopia. An important gene associated with Idiopathic Cd4-Positive T-Lymphocytopenia is BCL6 (BCL6 Transcription Repressor). The drugs Cholinergic Agents and Adjuvants, Immunologic have been mentioned in the context of this disorder. Affiliated tissues include t cells, testes and spinal cord.

Disease Ontology : 12 A lymphopenia that is caused by a reduction of CD4+ T lymphocytes.

Related Diseases for Idiopathic Cd4-Positive T-Lymphocytopenia

Diseases related to Idiopathic Cd4-Positive T-Lymphocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 immunodeficiency 13 12.5
2 myopia 10.5
3 progressive multifocal leukoencephalopathy 10.4
4 lymphopenia 10.4
5 keratoconus 10.3
6 astigmatism 10.2
7 cryptococcal meningitis 10.2
8 meningitis 10.2
9 astrocytoma 10.2
10 grade iii astrocytoma 10.2
11 primary effusion lymphoma 10.1
12 hematopoietic stem cell transplantation 10.1
13 histoplasmosis 10.1
14 pneumonia 10.1
15 mucormycosis 10.1
16 molluscum contagiosum 10.1
17 cryptococcosis 10.1
18 fanconi anemia, complementation group a 10.1
19 presbyopia 10.1
20 acute closed-angle glaucoma 10.1
21 autoimmune disease 10.0
22 kaposi sarcoma 10.0
23 myositis 10.0
24 lymphoma, hodgkin, classic 10.0
25 mycosis fungoides 10.0
26 sjogren syndrome 10.0
27 lymphoma, non-hodgkin, familial 10.0
28 autoimmune disease 1 10.0
29 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
30 diffuse large b-cell lymphoma 10.0
31 igg4-related disease 10.0
32 osteomyelitis 10.0
33 protein-losing enteropathy 10.0
34 blastomycosis 10.0
35 polyneuropathy 10.0
36 papilloma 10.0
37 retinitis 10.0
38 vasculitis 10.0
39 chickenpox 10.0
40 leishmaniasis 10.0
41 visceral leishmaniasis 10.0
42 orbit lymphoma 10.0
43 bowenoid papulosis 10.0
44 glioma 10.0
45 laryngeal papillomatosis 10.0
46 orbital lymphoma 10.0
47 epidermodysplasia verruciformis 1 10.0
48 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.0
49 lymphoma 10.0
50 meningoencephalitis 10.0

Graphical network of the top 20 diseases related to Idiopathic Cd4-Positive T-Lymphocytopenia:



Diseases related to Idiopathic Cd4-Positive T-Lymphocytopenia

Symptoms & Phenotypes for Idiopathic Cd4-Positive T-Lymphocytopenia

Drugs & Therapeutics for Idiopathic Cd4-Positive T-Lymphocytopenia

Drugs for Idiopathic Cd4-Positive T-Lymphocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cholinergic Agents Phase 2
2 Adjuvants, Immunologic Phase 2
3 Neurotransmitter Agents Phase 2
4 Pyridostigmine Bromide Phase 2 101-26-8
5 Immunologic Factors Phase 2
6 Cholinesterase Inhibitors Phase 2
7 Bromides Phase 2
8 Anticonvulsants Phase 2
9
Adenosine Approved, Investigational 58-61-7 60961
10
carbamide peroxide Approved 124-43-6

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pyridostigmine as Immunomodulator in People Living With HIV Active, not recruiting NCT03312244 Phase 2 Pyridostigmine Bromide;Placebo
2 Interleukin-7 (CYT107) Treatment of Idiopathic CD4 Lymphocytopenia: Expansion of CD4 T Cells (ICICLE) Terminated NCT00839436 Phase 1, Phase 2 CYT107
3 Idiopathic CD4 Lymphocytopenia Completed NCT02113930
4 Evaluation of HIV-Negative Patients With Low CD4+ T Lymphocyte Counts Completed NCT00001319
5 Hematopoietic Stem Cell Mobilization in Idiopathic CD4 Lymphocytopenia Patients and Healthy Controls for the Study of T Cell Maturation and Trafficking in Murine Models Recruiting NCT02015013
6 Etiology, Pathogenesis, and Natural History of Idiopathic CD4+ Lymphocytopenia Recruiting NCT00867269
7 Regional Differences in Human Immunodeficiency Virus (HIV) Testing Recruiting NCT03158987

Search NIH Clinical Center for Idiopathic Cd4-Positive T-Lymphocytopenia

Cochrane evidence based reviews: t-lymphocytopenia, idiopathic cd4-positive

Genetic Tests for Idiopathic Cd4-Positive T-Lymphocytopenia

Anatomical Context for Idiopathic Cd4-Positive T-Lymphocytopenia

MalaCards organs/tissues related to Idiopathic Cd4-Positive T-Lymphocytopenia:

42
T Cells, Testes, Spinal Cord, Neutrophil, B Cells

Publications for Idiopathic Cd4-Positive T-Lymphocytopenia

Articles related to Idiopathic Cd4-Positive T-Lymphocytopenia:

# Title Authors Year
1
Pleural cryptococcosis with idiopathic CD4 positive T-lymphocytopenia. ( 18827437 )
2008
2
Human herpes virus 8-negative primary effusion lymphoma with BCL6 rearrangement in a patient with idiopathic CD4 positive T-lymphocytopenia. ( 18166773 )
2008
3
Multiple flat warts associated with idiopathic CD4-positive T lymphocytopenia. ( 18191700 )
2008
4
Pleural cryptococcosis with idiopathic CD4 positive T-lymphocytopenia. ( 15575251 )
2004
5
Intracranial dissemination from thoracic spinal cord anaplastic astrocytoma in a patient with idiopathic CD4-positive T lymphocytopenia: a case report. ( 11546571 )
2001

Variations for Idiopathic Cd4-Positive T-Lymphocytopenia

Expression for Idiopathic Cd4-Positive T-Lymphocytopenia

Search GEO for disease gene expression data for Idiopathic Cd4-Positive T-Lymphocytopenia.

Pathways for Idiopathic Cd4-Positive T-Lymphocytopenia

GO Terms for Idiopathic Cd4-Positive T-Lymphocytopenia

Sources for Idiopathic Cd4-Positive T-Lymphocytopenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
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45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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