MCID: IDP034
MIFTS: 29

Idiopathic Central Precocious Puberty

Categories: Reproductive diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Idiopathic Central Precocious Puberty

MalaCards integrated aliases for Idiopathic Central Precocious Puberty:

Name: Idiopathic Central Precocious Puberty 59 73

Classifications:



External Ids:

Orphanet 59 ORPHA169615
ICD10 via Orphanet 34 E22.8
UMLS via Orphanet 74 C0342544
UMLS 73 C0342544

Summaries for Idiopathic Central Precocious Puberty

MalaCards based summary : Idiopathic Central Precocious Puberty is related to precocious puberty and central precocious puberty. An important gene associated with Idiopathic Central Precocious Puberty is MKRN3 (Makorin Ring Finger Protein 3), and among its related pathways/superpathways is Cardiac Progenitor Differentiation. Affiliated tissues include pituitary, bone and testes, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Related Diseases for Idiopathic Central Precocious Puberty

Graphical network of the top 20 diseases related to Idiopathic Central Precocious Puberty:



Diseases related to Idiopathic Central Precocious Puberty

Symptoms & Phenotypes for Idiopathic Central Precocious Puberty

MGI Mouse Phenotypes related to Idiopathic Central Precocious Puberty:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.8 IGF1 KCNK9 KISS1 KISS1R TAC3 TACR3
2 growth/size/body region MP:0005378 9.8 DLK1 IGF1 KISS1 KISS1R LIN28B TAC3
3 homeostasis/metabolism MP:0005376 9.76 DLK1 IGF1 KCNK9 KISS1 KISS1R LIN28B
4 adipose tissue MP:0005375 9.67 DLK1 IGF1 KISS1 KISS1R
5 normal MP:0002873 9.35 IGF1 KCNK9 KISS1R LIN28B TAC3
6 reproductive system MP:0005389 9.1 IGF1 KISS1 KISS1R TAC3 TACR3 DLK1

Drugs & Therapeutics for Idiopathic Central Precocious Puberty

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Psychosocial Impact of Early Puberty in Girls Aged 6 to 8 Years Completed NCT01679925
2 Long-term Outcome of GnRH Analogues Treatment of Children With Idiopathic Central Precocious Puberty Enrolling by invitation NCT02790112 Not Applicable

Search NIH Clinical Center for Idiopathic Central Precocious Puberty

Genetic Tests for Idiopathic Central Precocious Puberty

Anatomical Context for Idiopathic Central Precocious Puberty

MalaCards organs/tissues related to Idiopathic Central Precocious Puberty:

41
Pituitary, Bone, Testes, Ovary, Lung

Publications for Idiopathic Central Precocious Puberty

Articles related to Idiopathic Central Precocious Puberty:

(show top 50) (show all 63)
# Title Authors Year
1
Herbal medicine for idiopathic central precocious puberty: A protocol for a systematic review of controlled trials. ( 29595688 )
2018
2
Subnormal Growth Velocity And Related Factors During GnRH Analog Therapy For Idiopathic Central Precocious Puberty. ( 29687783 )
2018
3
Longitudinal follow-up to near final height of auxological changes in girls with idiopathic central precocious puberty treated with gonadotropin-releasing hormone analog and grouped by pretreatment body mass index level. ( 29609441 )
2018
4
Association between bisphenol a exposure and idiopathic central precocious puberty (ICPP) among school-aged girls in Shanghai, China. ( 29650233 )
2018
5
The mystery of puberty initiation: genetics and epigenetics of idiopathic central precocious puberty (ICPP). ( 28251550 )
2017
6
Metabolic Outcomes, Bone Health, and Risk of Polycystic Ovary Syndrome in Girls with Idiopathic Central Precocious Puberty Treated with Gonadotropin-Releasing Hormone Analogues. ( 28391271 )
2017
7
Effects of pomegranate extract in supplementing gonadotropin-releasing hormone therapy on idiopathic central precocious puberty in Chinese girls: a randomized, placebo-controlled, double-blind clinical trial. ( 28091641 )
2017
8
Molecular Screening of MKRN3, DLK1, and KCNK9 Genes in Girls with Idiopathic Central Precocious Puberty. ( 28672280 )
2017
9
Lung Function in Women with Idiopathic Central Precocious Puberty: A Pilot Studya8c. ( 28114141 )
2017
10
GnRH agonist treatment for idiopathic central precocious puberty can improve final adult height in Chinese girls. ( 29312590 )
2017
11
Commentary: Cognitive, Emotional, and Psychosocial Functioning of Girls Treated with Pharmacological Puberty Blockage for Idiopathic Central Precocious Puberty. ( 28167925 )
2017
12
Marked geographic patterns in the incidence of idiopathic central precocious puberty: a nationwide study in France. ( 28890442 )
2017
13
Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty. ( 28791667 )
2017
14
SERUM NESFATIN-1 LEVELS IN GIRLS WITH IDIOPATHIC CENTRAL PRECOCIOUS PUBERTY. ( 28739555 )
2017
15
Cognitive, Emotional, and Psychosocial Functioning of Girls Treated with Pharmacological Puberty Blockage for Idiopathic Central Precocious Puberty. ( 27462292 )
2016
16
NR0B1 Frameshift Mutation in a Boy with Idiopathic Central Precocious Puberty. ( 27648561 )
2016
17
Body mass index in girls with idiopathic central precocious puberty during and after treatment with GnRH analogues. ( 27499763 )
2016
18
Basal Serum Neurokinin B Level can be used to Differentiate Idiopathic Central Precocious Puberty from Premature Thelarche in Girls. ( 28008860 )
2016
19
Effects and safety of combination therapy with gonadotropin-releasing hormone analogue and growth hormone in girls with idiopathic central precocious puberty: a meta-analysis. ( 27225286 )
2016
20
Changes in Body Mass Index in Girls with Idiopathic Central Precocious Puberty under Gonadotropin-Releasing Hormone Analogue Therapy: The Spanish Registry. ( 27529349 )
2016
21
Clinical Exome Sequencing Reveals MKRN3 Pathogenic Variants in Familial and Nonfamilial Idiopathic Central Precocious Puberty. ( 27931036 )
2016
22
Association of genetic polymorphisms around the LIN28B gene and idiopathic central precocious puberty risks among Chinese girls. ( 27304100 )
2016
23
Impact of BMI on gonadorelin-stimulated LH peak in premenarcheal girls with idiopathic central precocious puberty. ( 25645648 )
2015
24
Genetic screening of the makorin ring finger 3 gene in girls with idiopathic central precocious puberty. ( 26402883 )
2015
25
Significance of serum neurokinin B and kisspeptin levels in the differential diagnosis of premature thelarche and idiopathic central precocious puberty. ( 25572302 )
2015
26
Use of a Gonadotropin-releasing Hormone Analog to Treat Idiopathic Central Precocious Puberty Is Not Associated with Changes in Bone Structure in Postmenarchal Adolescents. ( 26081481 )
2015
27
Efficacy and safety of domestic leuprorelin in girls with idiopathic central precocious puberty: a multicenter, randomized, parallel, controlled trial. ( 25963350 )
2015
28
Models for predicting the adult height and age at first menstruation of girls with idiopathic central precocious puberty. ( 25837693 )
2015
29
Testing of kisspeptin levels in girls with idiopathic central precocious puberty and its significance. ( 26136989 )
2015
30
Effect of GnRHa 3.75 mg subcutaneously every 6 weeks on adult height in girls with idiopathic central precocious puberty. ( 25719299 )
2015
31
Effect of gonadotropin-releasing hormone agonist therapy on body mass index and growth in girls with idiopathic central precocious puberty. ( 25729690 )
2015
32
Absence of GPR54 and TACR3 Mutations in Sporadic Cases of Idiopathic Central Precocious Puberty. ( 24434351 )
2014
33
Urinary zearalenone levels in girls with premature thelarche and idiopathic central precocious puberty. ( 25336100 )
2014
34
Mutational analysis of KISS1 and KISS1R in idiopathic central precocious puberty. ( 23950571 )
2014
35
Urinary bisphenol a levels in girls with idiopathic central precocious puberty. ( 24637305 )
2014
36
Mutational analysis of TAC and TACR3 in idiopathic central precocious puberty. ( 24802197 )
2014
37
The Usefulness of the Leuprolide Stimulation Test as a Diagnostic Method of Idiopathic Central Precocious Puberty in Girls. ( 25295414 )
2014
38
Presentation of 493 consecutive girls with idiopathic central precocious puberty: a single-center study. ( 23936254 )
2013
39
The side effects of gonadotropin releasing hormone analog (diphereline) in treatment of idiopathic central precocious puberty. ( 23456583 )
2013
40
Idiopathic central precocious puberty associated with 11a88mb de novo distal deletion of the chromosome 9 short arm. ( 23984122 )
2013
41
Absence of functional LIN28B mutations in a large cohort of patients with idiopathic central precocious puberty. ( 22964795 )
2012
42
Bone mineral density and body composition in girls with idiopathic central precocious puberty before and after treatment with a gonadotropin-releasing hormone agonist. ( 22760897 )
2012
43
A potential mechanism for the sexual dimorphism in the onset of puberty and incidence of idiopathic central precocious puberty in children: sex-specific kisspeptin as an integrator of puberty signals. ( 23248615 )
2012
44
The effect of gonadotropin-releasing hormone analog treatment (leuprolide) on body fat distribution in idiopathic central precocious puberty. ( 21534336 )
2011
45
Adult height, body mass index and time of menarche of girls with idiopathic central precocious puberty after gonadotropin-releasing hormone analogue treatment. ( 21501002 )
2011
46
Circulating kisspeptin levels exhibit sexual dimorphism in adults, are increased in obese prepubertal girls and do not suffer modifications in girls with idiopathic central precocious puberty. ( 21827808 )
2011
47
LIN28B, LIN28A, KISS1, and KISS1R in idiopathic central precocious puberty. ( 21939553 )
2011
48
Effect of treatment with cyproterone acetate on uterine bleeding at the beginning of GnRH analogue therapy in girls with idiopathic central precocious puberty. ( 20389110 )
2010
49
Prevalence of polycystic ovary syndrome in young women who had idiopathic central precocious puberty. ( 19135667 )
2010
50
Idiopathic central precocious puberty in girls: presentation factors. ( 18601733 )
2008

Variations for Idiopathic Central Precocious Puberty

Expression for Idiopathic Central Precocious Puberty

Search GEO for disease gene expression data for Idiopathic Central Precocious Puberty.

Pathways for Idiopathic Central Precocious Puberty

Pathways related to Idiopathic Central Precocious Puberty according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.35 IGF1 LIN28B

GO Terms for Idiopathic Central Precocious Puberty

Biological processes related to Idiopathic Central Precocious Puberty according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor signaling pathway GO:0007186 9.26 KISS1 KISS1R TAC3 TACR3
2 neuropeptide signaling pathway GO:0007218 9.16 KISS1R TAC3
3 tachykinin receptor signaling pathway GO:0007217 8.62 TAC3 TACR3

Sources for Idiopathic Central Precocious Puberty

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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
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74 UMLS via Orphanet
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