MCID: IDP034
MIFTS: 27

Idiopathic Central Precocious Puberty

Categories: Endocrine diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Idiopathic Central Precocious Puberty

MalaCards integrated aliases for Idiopathic Central Precocious Puberty:

Name: Idiopathic Central Precocious Puberty 58 70

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases
Rare endocrine diseases


External Ids:

ICD10 via Orphanet 33 E22.8
UMLS via Orphanet 71 C0342544
Orphanet 58 ORPHA169615
UMLS 70 C0342544

Summaries for Idiopathic Central Precocious Puberty

MalaCards based summary : Idiopathic Central Precocious Puberty is related to precocious puberty and central precocious puberty. An important gene associated with Idiopathic Central Precocious Puberty is MKRN3 (Makorin Ring Finger Protein 3), and among its related pathways/superpathways are Peptide ligand-binding receptors and GnRH secretion. Affiliated tissues include pituitary and ovary, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Related Diseases for Idiopathic Central Precocious Puberty

Diseases related to Idiopathic Central Precocious Puberty via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 precocious puberty 31.7 MKRN3 KISS1R KISS1
2 central precocious puberty 30.8 MKRN3 KISS1R KISS1 IGF1 DLK1
3 hypogonadotropic hypogonadism 29.7 TACR3 TAC3 PROKR2 KISS1R KISS1
4 silver-russell syndrome 1 29.7 IGF1 DLK1
5 hypogonadism 29.3 TACR3 TAC3 PROKR2 KISS1R KISS1 IGF1
6 normosmic congenital hypogonadotropic hypogonadism 29.3 TACR3 TAC3 PROKR2 KISS1R KISS1
7 kallmann syndrome 29.1 TACR3 TAC3 PROKR2 MKRN3 KISS1R KISS1
8 cryptorchidism, unilateral or bilateral 28.8 TACR3 TAC3 PROKR2 MKRN3 KISS1R KISS1
9 body mass index quantitative trait locus 1 10.6
10 polycystic ovary syndrome 10.5
11 hyperandrogenism 10.2
12 hypothalamic hamartomas 10.2 KISS1R KISS1
13 glucocorticoid deficiency 1 10.2 KISS1R KISS1
14 hypogonadotropic hypogonadism 7 with or without anosmia 10.1
15 precocious puberty, central, 1 10.1
16 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
17 insulin-like growth factor i 10.1
18 adrenal hypoplasia, congenital 10.1
19 pituitary adenoma, prolactin-secreting 10.1
20 precocious puberty, central, 2 10.1
21 alacrima, achalasia, and mental retardation syndrome 10.1
22 hyperprolactinemia 10.1
23 inguinal hernia 10.1
24 rickets 10.1
25 hyperinsulinism 10.1
26 infertility 10.1
27 retinal degeneration 10.1
28 47,xyy 10.1
29 isolated gonadotropin-releasing hormone deficiency 10.1
30 nr0b1-related adrenal hypoplasia congenita 10.1
31 diencephalic syndrome 10.1
32 autonomic dysfunction 10.1
33 retinitis pigmentosa 67 10.1 TACR3 TAC3
34 pituitary stalk interruption syndrome 10.0 PROKR2 KISS1R
35 choanal atresia, posterior 10.0 TACR3 PROKR2
36 coloboma of optic nerve 10.0 TACR3 PROKR2
37 growth hormone secreting pituitary adenoma 9.9 KISS1 IGF1
38 temple syndrome 9.9 MKRN3 KISS1 DLK1
39 anovulation 9.9 KISS1 IGF1
40 kagami-ogata syndrome 9.9 KISS1R KISS1 DLK1
41 pituitary hormone deficiency, combined, 2 9.9 PROKR2 IGF1
42 precocious puberty, male-limited 9.8 TAC3 MKRN3 KISS1R KISS1
43 amelogenesis imperfecta 9.7 KISS1R KISS1 IGF1
44 disorder of sexual development 9.7 PROKR2 KISS1 IGF1
45 beckwith-wiedemann syndrome 9.7 MKRN3 IGF1 DLK1
46 premature menopause 9.7 KISS1R KISS1 IGF1
47 charge syndrome 9.6 TACR3 TAC3 PROKR2 KISS1R
48 renal hypodysplasia/aplasia 1 9.6 TACR3 TAC3 PROKR2 KISS1R
49 prader-willi syndrome 9.6 MKRN3 IGF1 DLK1
50 septooptic dysplasia 9.6 PROKR2 IGF1

Graphical network of the top 20 diseases related to Idiopathic Central Precocious Puberty:



Diseases related to Idiopathic Central Precocious Puberty

Symptoms & Phenotypes for Idiopathic Central Precocious Puberty

MGI Mouse Phenotypes related to Idiopathic Central Precocious Puberty:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.8 IGF1 KCNK9 KISS1 KISS1R PROKR2 TAC3
2 growth/size/body region MP:0005378 9.76 DLK1 IGF1 KISS1 KISS1R LIN28B PROKR2
3 homeostasis/metabolism MP:0005376 9.65 DLK1 IGF1 KCNK9 KISS1 KISS1R LIN28B
4 reproductive system MP:0005389 9.17 DLK1 IGF1 KISS1 KISS1R PROKR2 TAC3

Drugs & Therapeutics for Idiopathic Central Precocious Puberty

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Influence of Early Adiposity Rebound, Genetic Polymorphisms and GnRHa Treatment on Long-term Outcome of Girls With Idiopathic Central Precocious Puberty. Unknown status NCT02790112

Search NIH Clinical Center for Idiopathic Central Precocious Puberty

Genetic Tests for Idiopathic Central Precocious Puberty

Anatomical Context for Idiopathic Central Precocious Puberty

MalaCards organs/tissues related to Idiopathic Central Precocious Puberty:

40
Pituitary, Ovary

Publications for Idiopathic Central Precocious Puberty

Articles related to Idiopathic Central Precocious Puberty:

(show top 50) (show all 183)
# Title Authors PMID Year
1
Noninvasive radiomics-based method for evaluating idiopathic central precocious puberty in girls. 61
33596690 2021
2
Molecular screening of PROKR2 gene in girls with idiopathic central precocious puberty. 61
33413516 2021
3
Long-term efficacy and safety of gonadotropin-releasing hormone analog treatment in children with idiopathic central precocious puberty: A systematic review and meta-analysis. 61
33387371 2021
4
Telomere length is not altered in girls with idiopathic central precocious puberty treated with a GnRH analog - leuprolide acetate. 61
32496827 2020
5
Idiopathic central precocious puberty in a Klinefelter patient: highlights on gonadotropin levels and pathophysiology. 61
33292161 2020
6
Herbal Medicine for Idiopathic Central Precocious Puberty: A Systematic Review and Meta-Analysis. 61
32654496 2020
7
Dual effects of a gonadotropin-releasing hormone agonist on an adolescent girl with pelvic congestion syndrome and precocious puberty: a case report. 61
32967508 2020
8
A novel heterozygous MKRN3 nonsense mutation in a Chinese girl with idiopathic central precocious puberty: A case report. 61
32957387 2020
9
Diagnostic value of pituitary volume in girls with precocious puberty. 61
32891123 2020
10
A diagnostic model of idiopathic central precocious puberty based on transrectal pelvic ultrasound and basal gonadotropin levels. 61
32762408 2020
11
Association study of DLK1 in girls with idiopathic central precocious puberty. 61
32623379 2020
12
Treatment with Depot Leuprolide Acetate in Girls with Idiopathic Precocious Puberty: What Parameter should be Used in Deciding on the Initial Dose? 61
31347350 2020
13
Long-Term Outcomes of Treatments for Central Precocious Puberty or Early and Fast Puberty in Chinese Girls. 61
31702013 2020
14
Arterial Spin Labeling and Central Precocious Puberty. 61
30397727 2020
15
Evaluation of serum makorin ring finger protein 3 (MKRN3) levels in girls with idiopathic central precocious puberty and premature thelarche. 61
31852205 2020
16
Long-term effects of GnRH agonist treatment on body mass index in girls with idiopathic central precocious puberty. 61
31804960 2020
17
Adequacy of basal luteinizing hormone levels in the diagnosis of central precocious puberty. 61
32684758 2020
18
Influence of Gonadotropin Hormone Releasing Hormone Agonists on Interhemispheric Functional Connectivity in Girls With Idiopathic Central Precocious Puberty. 61
32082242 2020
19
Near final adult height, and body mass index in overweight/obese and normal-weight children with idiopathic central precocious puberty and treated with gonadotropin-releasing hormone analogs. 61
31605579 2019
20
Elevated Random Luteinizing Hormone is an Unreliable Indicator for Pubertal Suppression in Girls Treated with Monthly Leuprolide for Idiopathic Central Precocious Puberty 61
30592192 2019
21
Comparing adult height gain and menarcheal age between girls with central precocious puberty treated with gonadotropin-releasing hormone agonist alone and those treated with combined growth hormone therapy. 61
31261476 2019
22
Endocrine abnormalities in cardiofaciocutaneous syndrome: a case of precocious puberty, hyperprolactinemia and diabetes insipidus. 61
31217210 2019
23
The Influence of Gonadotropin-Releasing Hormone Agonist Treatment on Thyroid Function Tests in Children with Central Idiopathic Precocious Puberty. 61
31391696 2019
24
The Association of Gut Microbiota With Idiopathic Central Precocious Puberty in Girls. 61
32038493 2019
25
Coincidental Central Precocious Puberty and Wilms Tumor in a 5-Year-Old Girl. 61
31583153 2019
26
Altered Brain Structure and Functional Connectivity Associated with Pubertal Hormones in Girls with Precocious Puberty. 61
31933625 2019
27
Pelvic Ultrasound in Diagnosing and Evaluating the Efficacy of Gonadotropin-Releasing Hormone Agonist Therapy in Girls With Idiopathic Central Precocious Puberty. 61
30804790 2019
28
The effect of overweight on the luteinizing hormone level after gonadorelin stimulation test in girls with idiopathic central precocious puberty. 61
30599483 2018
29
15q24.1 BP4-BP1 microdeletion unmasking paternally inherited functional polymorphisms combined with distal 15q24.2q24.3 duplication in a patient with epilepsy, psychomotor delay, overweight, ventricular arrhythmia. 61
29549028 2018
30
Serum levels of LH, IGF-1 and leptin in girls with idiopathic central precocious puberty (ICPP) and the correlations with the development of ICPP. 61
30037185 2018
31
Applicability of a novel mathematical model for the prediction of adult height and age at menarche in girls with idiopathic central precocious puberty. 61
30066730 2018
32
Subnormal Growth Velocity and Related Factors During GnRH Analog Therapy for Idiopathic Central Precocious Puberty 61
29687783 2018
33
Comparison of two bone markers with growth evolution in 74 girls with central precocious puberty. 61
29986677 2018
34
Investigation of MKRN3 Mutation in Patients with Familial Central Precocious Puberty 61
29537379 2018
35
Association between bisphenol a exposure and idiopathic central precocious puberty (ICPP) among school-aged girls in Shanghai, China. 61
29650233 2018
36
Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty. 61
28791667 2018
37
Herbal medicine for idiopathic central precocious puberty: A protocol for a systematic review of controlled trials. 61
29595688 2018
38
Longitudinal follow-up to near final height of auxological changes in girls with idiopathic central precocious puberty treated with gonadotropin-releasing hormone analog and grouped by pretreatment body mass index level. 61
29609441 2018
39
Serum Nesfatin-1 Levels in Girls with Idiopathic Central Precocious Puberty. 61
28739555 2018
40
A new efficient method to monitor precocious puberty nationwide in France. 61
28975428 2018
41
Increased final adult height by gonadotropin-releasing hormone agonist in girls with idiopathic central precocious puberty. 61
30133462 2018
42
Serum inhibin B concentration as a predictor of age at first menstruation in girls with idiopathic central precocious puberty. 61
30550563 2018
43
A mathematical model for predicting the adult height of girls with idiopathic central precocious puberty: A European validation. 61
30300409 2018
44
Marked geographic patterns in the incidence of idiopathic central precocious puberty: a nationwide study in France. 61
28890442 2018
45
Is a Combination of a GnRH Agonist and Recombinant Growth Hormone an Effective Treatment to Increase the Final Adult Height of Girls with Precocious or Early Puberty? 61
30693027 2018
46
GnRH agonist treatment for idiopathic central precocious puberty can improve final adult height in Chinese girls. 61
29312590 2017
47
[An analysis of cardiac autonomic nerve function in girls with idiopathic central precocious puberty]. 61
29237522 2017
48
There is no association between vitamin D status and characteristics of central precocious puberty in girls. 61
28963633 2017
49
Independent relationship between body mass index and LH peak value of GnRH stimulation test in ICPP girls: A cross-sectional study. 61
28786058 2017
50
The mystery of puberty initiation: genetics and epigenetics of idiopathic central precocious puberty (ICPP). 61
28251550 2017

Variations for Idiopathic Central Precocious Puberty

Expression for Idiopathic Central Precocious Puberty

Search GEO for disease gene expression data for Idiopathic Central Precocious Puberty.

Pathways for Idiopathic Central Precocious Puberty

GO Terms for Idiopathic Central Precocious Puberty

Biological processes related to Idiopathic Central Precocious Puberty according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.65 TACR3 TAC3 PROKR2 KISS1R KISS1
2 positive regulation of blood pressure GO:0045777 9.16 TACR3 TAC3
3 neuropeptide signaling pathway GO:0007218 9.13 TAC3 PROKR2 KISS1R
4 tachykinin receptor signaling pathway GO:0007217 8.62 TACR3 TAC3

Sources for Idiopathic Central Precocious Puberty

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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