MCID: IDP006
MIFTS: 18

Idiopathic Corneal Edema

Categories: Neuronal diseases

Aliases & Classifications for Idiopathic Corneal Edema

MalaCards integrated aliases for Idiopathic Corneal Edema:

Name: Idiopathic Corneal Edema 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:11033
ICD9CM 34 371.21
SNOMED-CT 67 193813009
ICD10 32 H18.22
UMLS 70 C0155109

Summaries for Idiopathic Corneal Edema

MalaCards based summary : Idiopathic Corneal Edema is related to corneal disease and corneal edema. An important gene associated with Idiopathic Corneal Edema is KRT8 (Keratin 8), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization.

Related Diseases for Idiopathic Corneal Edema

Diseases related to Idiopathic Corneal Edema via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 corneal disease 9.9
2 corneal edema 9.9
3 bullous keratopathy 9.9
4 keratopathy 9.9
5 proliferating trichilemmal cyst 9.9 KRT8 KRT19
6 intrahepatic gall duct cancer 9.9 KRT8 KRT19
7 squamous cell bile duct carcinoma 9.9 KRT8 KRT19
8 odontoma 9.9 KRT8 KRT19
9 hidrocystoma 9.8 KRT8 KRT19
10 eccrine papillary adenocarcinoma 9.8 KRT8 KRT19
11 sarcomatous intrahepatic cholangiocarcinoma 9.8 KRT8 KRT19
12 cholangiocarcinoma 9.8 KRT8 KRT19
13 cutaneous adenocystic carcinoma 9.8 KRT8 KRT19
14 mucinous tubular and spindle renal cell carcinoma 9.8 KRT8 KRT19
15 adenoid squamous cell carcinoma 9.8 KRT8 KRT19
16 uterus leiomyosarcoma 9.8 KRT8 KRT19
17 uterine corpus sarcoma 9.8 KRT8 KRT19
18 eccrine papillary adenoma 9.8 KRT8 KRT19
19 lymphoepithelioma-like carcinoma 9.8 KRT8 KRT19
20 basaloid squamous cell carcinoma 9.8 KRT8 KRT19
21 sweat gland cancer 9.8 KRT8 KRT19
22 fibrolamellar carcinoma 9.8 KRT8 KRT19
23 primary cutaneous amyloidosis 9.8 KRT8 KRT19
24 brooke-spiegler syndrome 9.8 KRT8 KRT19
25 ameloblastoma 9.8 KRT8 KRT19
26 pre-malignant neoplasm 9.8 KRT8 KRT19
27 adenosquamous carcinoma 9.8 KRT8 KRT19
28 small cell carcinoma 9.8 KRT8 KRT19
29 breast carcinoma in situ 9.8 KRT8 KRT19
30 oncocytoma 9.8 KRT8 KRT19
31 viral hepatitis 9.8 KRT8 KRT19
32 sarcoma, synovial 9.7 KRT8 KRT19
33 chromophobe renal cell carcinoma 9.7 KRT8 KRT19
34 breast ductal carcinoma 9.7 KRT8 KRT19
35 transitional cell carcinoma 9.7 KRT8 KRT19
36 hepatoblastoma 9.7 KRT8 KRT19
37 basal cell carcinoma 9.6 KRT8 KRT19
38 liver disease 9.6 KRT8 KRT19
39 skin carcinoma 9.5 KRT8 KRT19

Graphical network of the top 20 diseases related to Idiopathic Corneal Edema:



Diseases related to Idiopathic Corneal Edema

Symptoms & Phenotypes for Idiopathic Corneal Edema

Drugs & Therapeutics for Idiopathic Corneal Edema

Search Clinical Trials , NIH Clinical Center for Idiopathic Corneal Edema

Genetic Tests for Idiopathic Corneal Edema

Anatomical Context for Idiopathic Corneal Edema

Publications for Idiopathic Corneal Edema

Articles related to Idiopathic Corneal Edema:

# Title Authors PMID Year
1
Five-Year-Old Sequestered Retained Lens Fragment Requiring Keratoplasty. 61
32864254 2020
2
Zipper cell endotheliopathy: a new subset of idiopathic corneal edema. 61
20705342 2010
3
Corneal edema after pediatric cataract surgery. 61
10875086 1997

Variations for Idiopathic Corneal Edema

Expression for Idiopathic Corneal Edema

Search GEO for disease gene expression data for Idiopathic Corneal Edema.

Pathways for Idiopathic Corneal Edema

Pathways related to Idiopathic Corneal Edema according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.75 KRT8 KRT19
2
Show member pathways
11.61 KRT8 KRT19
3
Show member pathways
10.99 KRT8 KRT19
4 10.17 KRT8 KRT19

GO Terms for Idiopathic Corneal Edema

Cellular components related to Idiopathic Corneal Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.4 KRT8 KRT19
2 Z disc GO:0030018 9.37 KRT8 KRT19
3 sarcolemma GO:0042383 9.32 KRT8 KRT19
4 cell periphery GO:0071944 9.26 KRT19 KRT8
5 apicolateral plasma membrane GO:0016327 9.16 KRT8 KRT19
6 costamere GO:0043034 8.96 KRT8 KRT19
7 dystrophin-associated glycoprotein complex GO:0016010 8.62 KRT8 KRT19

Biological processes related to Idiopathic Corneal Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.32 KRT8 KRT19
2 keratinization GO:0031424 9.26 KRT8 KRT19
3 cornification GO:0070268 9.16 KRT8 KRT19
4 sarcomere organization GO:0045214 8.96 KRT8 KRT19
5 cell differentiation involved in embryonic placenta development GO:0060706 8.62 KRT19 KRT8

Molecular functions related to Idiopathic Corneal Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex binding GO:0044877 8.62 KRT19 KRT8

Sources for Idiopathic Corneal Edema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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